ramipril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2356 87333-19-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • HOE498
  • HOE-498
  • ramipril
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
  • Molecular weight: 416.52
  • Formula: C23H32N2O5
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.03
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.09 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.154 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 4.207 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 4.875 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 12.764 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 12.450 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 13.250 % High 1
herg hERG pIC50 4.267 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 14.223 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 15.596 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 13.490 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 21
kinase-selectivity-class AXL,BRAF,GRK2,MAP2K6 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.148 Moderate 0.68
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.442 High 1
mh-clint Mouse hepatocyte intrinsic clearance 62.661 High 1
mppb Mouse plasma protein binding (% unbound) 10.690 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.278 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 15.130 % High 1
rat-kpuu-brain Rat brain Kpuu 0.008 % Moderate 0.68
rh-clint Rat hepatocyte intrinsic clearance 84.333 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 83.330 % High 1
rppb Rat plasma protein binding (% unbound) 11.460 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 984.011 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 28, 1991 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver injury 696.54 10.22 1865 360067 168702 90097813
Product dose omission issue 635.30 10.22 188 361744 291499 89975016
Drug ineffective 610.44 10.22 3157 358775 1381141 88885374
General physical health deterioration 558.77 10.22 2848 359084 352267 89914248
Hyperkalaemia 516.08 10.22 929 361003 64035 90202480
Acute kidney injury 504.93 10.22 2571 359361 317816 89948699
Psoriatic arthropathy 483.53 10.22 1999 359933 226336 90040179
Hyponatraemia 450.25 10.22 1363 360569 132175 90134340
Completed suicide 438.19 10.22 38 361894 145020 90121495
Death 391.94 10.22 769 361163 455782 89810733
Injection site pain 312.85 10.22 151 361781 173548 90092967
Confusional state 298.50 10.22 2594 359338 383611 89882904
Peripheral venous disease 287.85 10.22 862 361070 83059 90183456
Type 2 diabetes mellitus 271.67 10.22 1560 360372 201684 90064831
White blood cell count decreased 247.91 10.22 183 361749 166926 90099589
Rheumatic fever 238.13 10.22 1225 360707 151896 90114619
Injection site erythema 232.30 10.22 54 361878 98448 90168067
Product prescribing error 231.60 10.22 425 361507 29720 90236795
Pulmonary fibrosis 228.70 10.22 943 360989 106560 90159955
Lip dry 220.64 10.22 893 361039 100062 90166453
Angioedema 212.73 10.22 656 361276 64220 90202295
Breast cancer stage III 204.03 10.22 771 361161 83676 90182839
Blood cholesterol increased 197.40 10.22 1465 360467 206547 90059968
Hypercholesterolaemia 196.02 10.22 861 361071 100031 90166484
Mobility decreased 195.49 10.22 1688 360244 249046 90017469
Hypertensive crisis 193.33 10.22 293 361639 17491 90249024
Wound infection 191.73 10.22 888 361044 105514 90161001
Obesity 188.25 10.22 878 361054 104629 90161886
Disease progression 186.51 10.22 210 361722 156405 90110110
Back pain 184.87 10.22 648 361284 316527 89949988
Off label use 180.61 10.22 3209 358723 1099043 89167472
Lactic acidosis 177.43 10.22 523 361409 49940 90216575
Rheumatoid arthritis 177.42 10.22 2220 359712 360394 89906121
Fibromyalgia 173.15 10.22 1412 360520 204857 90061658
Platelet count decreased 172.75 10.22 175 361757 136794 90129721
Night sweats 171.06 10.22 987 360945 127779 90138736
Febrile neutropenia 170.99 10.22 229 361703 158120 90108395
Joint range of motion decreased 168.79 10.22 1022 360910 134621 90131894
Pemphigus 167.16 10.22 2018 359914 324846 89941669
Facet joint syndrome 165.53 10.22 805 361127 97584 90168931
Toxicity to various agents 162.46 10.22 596 361336 287250 89979265
Bursitis 161.31 10.22 988 360944 130666 90135849
Bradycardia 160.93 10.22 713 361219 83134 90183381
Neuropathy peripheral 160.54 10.22 186 361746 136784 90129731
Wrong technique in product usage process 155.87 10.22 46 361886 71525 90194990
Deep vein thrombosis postoperative 154.41 10.22 626 361306 70183 90196332
Eosinophilic bronchitis 154.10 10.22 67 361865 576 90265939
Neutropenia 153.23 10.22 428 361504 224476 90042039
Product monitoring error 152.08 10.22 134 361798 4410 90262105
Pericarditis 149.69 10.22 1694 360238 268457 89998058
Therapy interrupted 146.30 10.22 15 361917 50093 90216422
Swollen joint count increased 146.13 10.22 850 361082 110356 90156159
Musculoskeletal pain 144.61 10.22 1174 360758 170077 90096438
Device expulsion 144.48 10.22 4 361928 40882 90225633
Duodenal ulcer perforation 143.82 10.22 1433 360499 219855 90046660
Drug interaction 140.08 10.22 1704 360228 274749 89991766
Abdominal pain upper 136.78 10.22 1974 359958 330700 89935815
Lung disorder 136.71 10.22 1046 360886 148837 90117678
Injection site pruritus 136.25 10.22 25 361907 53809 90212706
Upper respiratory tract infection 136.08 10.22 188 361744 128130 90138385
Unevaluable event 135.57 10.22 27 361905 54821 90211694
Blepharospasm 135.38 10.22 508 361424 54937 90211578
Constipation 134.20 10.22 619 361313 279776 89986739
Rheumatoid factor positive 132.33 10.22 1153 360779 170497 90096018
Wound 131.85 10.22 1816 360116 301164 89965351
C-reactive protein abnormal 131.52 10.22 916 361016 126513 90140002
Autoimmune disorder 131.30 10.22 631 361301 76113 90190402
Feeling abnormal 130.38 10.22 297 361635 166938 90099577
Taste disorder 129.37 10.22 538 361394 61008 90205507
Angina pectoris 129.31 10.22 397 361535 38763 90227752
Abortion spontaneous 128.71 10.22 29 361903 54027 90212488
Muscle injury 128.17 10.22 1171 360761 175483 90091032
Injection site swelling 127.53 10.22 40 361892 59799 90206716
Sopor 127.31 10.22 295 361637 24349 90242166
Grip strength decreased 124.49 10.22 712 361220 91864 90174651
Seizure 123.96 10.22 265 361667 152364 90114151
Drug ineffective for unapproved indication 122.92 10.22 56 361876 66588 90199927
Glossodynia 122.37 10.22 1884 360048 319895 89946620
X-ray abnormal 118.32 10.22 425 361507 44999 90221516
Syncope 118.29 10.22 921 361011 131742 90134773
Bronchitis 117.27 10.22 274 361658 152653 90113862
Nail disorder 116.92 10.22 507 361425 58560 90207955
Urinary tract infection 115.66 10.22 730 361202 304902 89961613
Sciatica 115.56 10.22 747 361185 100635 90165880
Live birth 115.42 10.22 622 361310 78485 90188030
Folliculitis 113.86 10.22 1283 360649 203070 90063445
Gait inability 113.52 10.22 985 360947 145471 90121044
Hand deformity 113.36 10.22 1737 360195 294625 89971890
Helicobacter infection 111.73 10.22 1391 360541 225459 90041056
Gangrene 111.08 10.22 191 361741 12685 90253830
Anti-cyclic citrullinated peptide antibody positive 107.69 10.22 1429 360503 235004 90031511
Dry mouth 107.29 10.22 1166 360766 182893 90083622
Adjustment disorder with depressed mood 106.92 10.22 480 361452 56273 90210242
Onychomadesis 105.37 10.22 413 361519 45585 90220930
Myelosuppression 105.31 10.22 41 361891 53550 90212965
Systemic lupus erythematosus 103.38 10.22 2024 359908 359872 89906643
Arterial occlusive disease 102.65 10.22 181 361751 12265 90254250
Lower respiratory tract infection 102.02 10.22 1485 360447 249174 90017341
Injury 101.46 10.22 1220 360712 196129 90070386
Labelled drug-drug interaction medication error 101.35 10.22 197 361735 14385 90252130
Lip swelling 101.20 10.22 362 361570 38248 90228267
Dislocation of vertebra 100.71 10.22 467 361465 55501 90211014
COVID-19 100.28 10.22 342 361590 168501 90098014
Epilepsy 98.20 10.22 613 361319 81593 90184922
Arthropathy 98.19 10.22 2029 359903 364213 89902302
Carotid artery thrombosis 97.70 10.22 149 361783 8943 90257572
Surgery 97.47 10.22 29 361903 44858 90221657
Neurologic neglect syndrome 96.50 10.22 146 361786 8701 90257814
Chills 96.04 10.22 243 361689 131738 90134777
Malignant neoplasm progression 95.87 10.22 175 361757 106695 90159820
Macular degeneration 95.30 10.22 18 361914 37952 90228563
Neutrophil count decreased 95.29 10.22 87 361845 71445 90195070
Prescribed overdose 95.04 10.22 692 361240 96933 90169582
Pain 94.50 10.22 3148 358784 993193 89273322
Lower limb fracture 93.60 10.22 621 361311 84392 90182123
Multiple sclerosis relapse 93.32 10.22 46 361886 52259 90214256
Mental status changes 93.20 10.22 31 361901 44648 90221867
Fungal infection 91.84 10.22 28 361904 42633 90223882
Accidental exposure to product 90.85 10.22 28 361904 42338 90224177
C-reactive protein increased 90.48 10.22 1115 360817 180274 90086241
Lupus vulgaris 88.59 10.22 386 361546 44673 90221842
Tongue oedema 88.32 10.22 109 361823 5345 90261170
Dry eye 87.75 10.22 62 361870 57869 90208646
Blister 86.77 10.22 1466 360466 253532 90012983
Flushing 86.64 10.22 137 361795 88354 90178161
Irritable bowel syndrome 85.58 10.22 1232 360700 206216 90060299
Subcutaneous drug absorption impaired 84.58 10.22 175 361757 13370 90253145
Inappropriate schedule of product administration 84.15 10.22 311 361621 149622 90116893
Illness 84.01 10.22 123 361809 81846 90184669
Respiratory failure 83.88 10.22 221 361711 118197 90148318
Inflammation 83.20 10.22 1084 360848 177508 90089007
Nasal congestion 82.75 10.22 128 361804 83286 90183229
Osteoarthritis 82.57 10.22 1167 360765 194563 90071952
Ulcer haemorrhage 82.43 10.22 262 361670 26059 90240456
Prescribed underdose 81.98 10.22 547 361385 74472 90192043
Fatigue 81.39 10.22 3775 358157 1150248 89116267
Melaena 79.35 10.22 312 361620 34485 90232030
Hypotension 78.92 10.22 1777 360155 323620 89942895
Delirium 78.31 10.22 697 361235 103662 90162853
Swollen tongue 77.97 10.22 377 361555 45579 90220936
Adjustment disorder 77.95 10.22 139 361793 9503 90257012
Sleep disorder 77.72 10.22 1166 360766 196864 90069651
Sepsis 75.67 10.22 415 361517 179399 90087116
Hemiparesis 75.57 10.22 289 361643 31530 90234985
Chronic sinusitis 75.34 10.22 5 361927 23797 90242718
Ischaemic stroke 75.32 10.22 227 361705 21939 90244576
Personality disorder 74.47 10.22 158 361774 12286 90254229
Breast cancer stage II 74.35 10.22 309 361623 35025 90231490
Suicidal ideation 73.58 10.22 113 361819 73742 90192773
Intentional product use issue 73.43 10.22 1246 360686 215646 90050869
Dizziness 72.74 10.22 2960 358972 586324 89680191
No adverse event 72.66 10.22 99 361833 67883 90198632
Eye irritation 71.89 10.22 23 361909 33955 90232560
Therapy cessation 71.14 10.22 28 361904 36333 90230182
Incorrect dose administered 71.01 10.22 129 361803 78801 90187714
Muscular weakness 70.23 10.22 1188 360744 205478 90061037
Hypoglycaemia 69.65 10.22 498 361434 69350 90197165
Polyp 69.40 10.22 116 361816 7528 90258987
Injection site rash 68.62 10.22 8 361924 24165 90242350
Productive cough 68.39 10.22 127 361805 76936 90189579
Herpes zoster 67.50 10.22 176 361756 94468 90172047
Oral candidiasis 66.63 10.22 29 361903 35426 90231089
Hospitalisation 66.58 10.22 274 361658 127826 90138689
Wheezing 66.38 10.22 1327 360605 236753 90029762
Device issue 66.13 10.22 18 361914 29519 90236996
Memory impairment 65.99 10.22 1131 360801 196113 90070402
Injection site bruising 65.73 10.22 67 361865 52240 90214275
Motor dysfunction 65.40 10.22 197 361735 19033 90247482
Product quality issue 65.39 10.22 541 361391 78784 90187731
Drug withdrawal syndrome 65.27 10.22 17 361915 28706 90237809
Device malfunction 64.69 10.22 5 361927 20972 90245543
Cardio-respiratory arrest 64.45 10.22 95 361837 63045 90203470
Hepatic function abnormal 64.43 10.22 54 361878 46234 90220281
Oedema 64.32 10.22 1141 360791 199154 90067361
Product label confusion 64.00 10.22 219 361713 22631 90243884
Pustular psoriasis 63.96 10.22 191 361741 18365 90248150
Therapeutic response unexpected 62.72 10.22 7 361925 21873 90244642
Orthostatic intolerance 62.22 10.22 48 361884 1306 90265209
Hypoxia 61.04 10.22 123 361809 72276 90194239
Onychomycosis 60.12 10.22 302 361630 37074 90229441
Rhabdomyolysis 59.83 10.22 380 361552 50876 90215639
Hemiplegia 59.21 10.22 170 361762 15990 90250525
Cytokine release syndrome 59.07 10.22 19 361913 27954 90238561
Rash vesicular 58.70 10.22 183 361749 18014 90248501
Respiratory arrest 58.36 10.22 30 361902 33281 90233234
Headache 58.31 10.22 2834 359098 859912 89406603
Medication error 58.26 10.22 555 361377 84097 90182418
Plasma cell myeloma 57.61 10.22 47 361885 40781 90225734
Cardiac failure 57.59 10.22 680 361252 108816 90157699
Red blood cell count decreased 57.53 10.22 60 361872 46291 90220224
Device dislocation 57.21 10.22 27 361905 31455 90235060
Foetal death 56.08 10.22 8 361924 20715 90245800
Exostosis 56 10.22 384 361548 52750 90213765
Procedural pain 55.60 10.22 32 361900 33328 90233187
Dry skin 55.31 10.22 174 361758 87899 90178616
Injection site haemorrhage 55.09 10.22 22 361910 28296 90238219
Myositis 54.74 10.22 216 361716 23912 90242603
Device difficult to use 54.55 10.22 4 361928 17521 90248994
Synovitis 54.32 10.22 1712 360220 328040 89938475
Cellulitis 54.21 10.22 185 361747 91152 90175363
Drug tolerance 53.98 10.22 176 361756 17740 90248775
Seasonal allergy 53.39 10.22 13 361919 22970 90243545
Retinitis 53.14 10.22 298 361634 38160 90228355
Dermatitis atopic 53.13 10.22 14 361918 23458 90243057
Radiculopathy 52.84 10.22 6 361926 18499 90248016
Dyspepsia 52.75 10.22 1097 360835 197063 90069452
Presyncope 52.58 10.22 259 361673 31546 90234969
Pyrexia 52.48 10.22 2131 359801 658354 89608161
Musculoskeletal stiffness 51.89 10.22 1551 360381 294981 89971534
Rhinitis allergic 51.76 10.22 4 361928 16781 90249734
Stress 51.68 10.22 160 361772 81235 90185280
Sedation 51.63 10.22 70 361862 48101 90218414
C-reactive protein 51.55 10.22 255 361677 31112 90235403
Injection site urticaria 51.03 10.22 6 361926 18005 90248510
Porphyria acute 50.97 10.22 173 361759 17802 90248713
Thrombosis 50.88 10.22 138 361794 73113 90193402
Product dose omission in error 50.86 10.22 10 361922 20493 90246022
Vision blurred 50.64 10.22 247 361685 110046 90156469
Asphyxia 50.64 10.22 97 361835 7006 90259509
Tremor 49.92 10.22 382 361550 152791 90113724
Coordination abnormal 49.92 10.22 193 361739 21163 90245352
Systemic infection 49.55 10.22 77 361855 4698 90261817
Contraindicated product administered 49.33 10.22 1649 360283 318490 89948025
Back injury 49.17 10.22 337 361595 46285 90220230
Bacteraemia 49.16 10.22 14 361918 22286 90244229
Proctitis 48.91 10.22 3 361929 15256 90251259
Intentional product misuse 48.88 10.22 188 361744 89416 90177099
Hepatotoxicity 48.74 10.22 67 361865 45775 90220740
Blood pressure increased 48.70 10.22 1080 360852 196137 90070378
General symptom 48.69 10.22 149 361783 14519 90251996
Dysphonia 48.36 10.22 113 361819 62971 90203544
Drug resistance 48.24 10.22 31 361901 30418 90236097
Incorrect route of product administration 48.20 10.22 357 361575 50269 90216246
Road traffic accident 47.91 10.22 648 361284 106978 90159537
Intentional dose omission 47.80 10.22 7 361925 17776 90248739
Renin increased 47.76 10.22 21 361911 186 90266329
Nephritic syndrome 47.71 10.22 26 361906 381 90266134
Disease recurrence 47.57 10.22 48 361884 37605 90228910
Full blood count abnormal 46.99 10.22 46 361886 36551 90229964
Joint injury 46.84 10.22 37 361895 32627 90233888
Haematocrit decreased 46.67 10.22 59 361873 41773 90224742
Acne 46.58 10.22 28 361904 28479 90238036
Orthostatic hypotension 46.31 10.22 306 361626 41521 90224994
Impaired healing 45.96 10.22 1243 360689 232956 90033559
Irritability 45.59 10.22 45 361887 35617 90230898
Affect lability 45.34 10.22 167 361765 17896 90248619
Rash 45.30 10.22 2660 359272 793440 89473075
Coma 45.25 10.22 144 361788 72488 90194027
Grip strength 44.86 10.22 106 361826 8859 90257656
Breast cancer female 44.66 10.22 4 361928 14882 90251633
Neurotoxicity 44.59 10.22 15 361917 21452 90245063
Pain in jaw 44.44 10.22 77 361855 47908 90218607
Hypersensitivity myocarditis 44.22 10.22 22 361910 264 90266251
Change of bowel habit 44.21 10.22 50 361882 2233 90264282
Sensory loss 43.61 10.22 165 361767 17910 90248605
Multiple sclerosis 43.22 10.22 29 361903 27811 90238704
Balance disorder 43.09 10.22 220 361712 96860 90169655
Circulatory collapse 42.75 10.22 205 361727 24699 90241816
Clostridium difficile infection 42.69 10.22 49 361883 36196 90230319
Eye pain 42.64 10.22 69 361863 44099 90222416
Therapeutic response shortened 42.54 10.22 19 361913 22860 90243655
Laryngitis 42.29 10.22 347 361585 50406 90216109
Blood potassium decreased 42.04 10.22 79 361853 47648 90218867
Skin haemorrhage 41.91 10.22 183 361749 21197 90245318
Neoplasm malignant 41.89 10.22 44 361888 33836 90232679
Vaginal haemorrhage 41.68 10.22 38 361894 31233 90235282
Paraesthesia 41.55 10.22 1301 360631 249025 90017490
Cardiac failure congestive 41.38 10.22 228 361704 98466 90168049
Cytomegalovirus infection 40.91 10.22 28 361904 26574 90239941
Urticaria 40.60 10.22 1580 360352 311154 89955361
Respiratory tract infection 40.51 10.22 112 361820 58966 90207549
Joint destruction 40.46 10.22 131 361801 13156 90253359
Food allergy 40.28 10.22 26 361906 25452 90241063
Ejection fraction decreased 40.04 10.22 209 361723 26044 90240471
Haematemesis 39.95 10.22 251 361681 33475 90233040
Atrial fibrillation 38.65 10.22 749 361183 132862 90133653
Migraine 38.64 10.22 1015 360917 189377 90077138
Pulmonary arterial hypertension 38.39 10.22 29 361903 26158 90240357
Dysarthria 38.38 10.22 359 361573 54123 90212392
Electrolyte imbalance 38.28 10.22 192 361740 23553 90242962
Foetal exposure during pregnancy 37.97 10.22 71 361861 42904 90223611
Intestinal obstruction 37.77 10.22 56 361876 37075 90229440
Renal disorder 37.63 10.22 58 361874 37801 90228714
Pruritus 37.63 10.22 1773 360159 539752 89726763
Influenza 37.49 10.22 365 361567 138899 90127616
Ocular hyperaemia 37.36 10.22 48 361884 33750 90232765
Somnolence 37.11 10.22 599 361333 208485 90058030
Hot flush 37.02 10.22 118 361814 59370 90207145
Oxygen saturation decreased 36.96 10.22 264 361668 107219 90159296
Dehydration 36.72 10.22 1027 360905 193420 90073095
Pharyngitis streptococcal 36.72 10.22 4 361928 12738 90253777
Colitis 36.71 10.22 149 361783 69793 90196722
Device breakage 36.68 10.22 6 361926 14038 90252477
Acute myocardial infarction 36.67 10.22 252 361680 34638 90231877
Hip fracture 36.54 10.22 47 361885 33030 90233485
Bradyarrhythmia 36.38 10.22 47 361885 2414 90264101
Stomatitis 35.92 10.22 1389 360543 273309 89993206
Respiratory depression 35.81 10.22 9 361923 15566 90250949
Carpal tunnel syndrome 35.72 10.22 26 361906 23902 90242613
Oral herpes 35.64 10.22 49 361883 33475 90233040
Finger deformity 35.41 10.22 239 361693 32658 90233857
Arthralgia 35.35 10.22 2654 359278 775868 89490647
Pharyngitis 35.24 10.22 22 361910 21925 90244590
Nephrolithiasis 35.21 10.22 91 361841 48994 90217521
Erythema 35.18 10.22 674 361258 228572 90037943
Candida infection 34.99 10.22 51 361881 34006 90232509
Diabetic metabolic decompensation 34.77 10.22 41 361891 1916 90264599
Brain oedema 34.65 10.22 13 361919 17372 90249143
Breast cancer 34.61 10.22 105 361827 53656 90212859
Rash erythematous 34.61 10.22 138 361794 64966 90201549
Dystonia 34.51 10.22 12 361920 16807 90249708
Product storage error 34.33 10.22 19 361913 20222 90246293
Skin discolouration 34.27 10.22 79 361853 44236 90222279
Neutrophilia 34.15 10.22 73 361859 5705 90260810
Temperature intolerance 34.10 10.22 4 361928 12026 90254489
Ill-defined disorder 33.93 10.22 973 360959 183918 90082597
Metastases to liver 33.86 10.22 39 361893 28768 90237747
Bicuspid aortic valve 33.53 10.22 15 361917 139 90266376
Sedation complication 33.23 10.22 13 361919 16931 90249584
Infusion site erythema 33.22 10.22 7 361925 13663 90252852
Hypocholesterolaemia 33.09 10.22 77 361855 6372 90260143
Jaundice 33.08 10.22 233 361699 32284 90234231
Discomfort 33.05 10.22 1375 360557 272960 89993555
Dermatitis contact 32.96 10.22 7 361925 13588 90252927
Pancytopenia 32.88 10.22 314 361618 119949 90146566
Pulmonary mass 32.70 10.22 40 361892 28732 90237783
Decreased appetite 32.64 10.22 1827 360105 374713 89891802
Product complaint 32.63 10.22 7 361925 13493 90253022
Atrioventricular block first degree 32.61 10.22 91 361841 8420 90258095
Nasal polyps 32.43 10.22 3 361929 10877 90255638
Tenosynovitis 32.38 10.22 9 361923 14558 90251957
Staphylococcal infection 32.35 10.22 93 361839 48346 90218169
Neuroleptic malignant syndrome 32.33 10.22 10 361922 15086 90251429
Pulmonary toxicity 32.28 10.22 4 361928 11527 90254988
Red blood cell sedimentation rate increased 32.24 10.22 486 361446 82109 90184406
Colitis microscopic 32.17 10.22 108 361824 11051 90255464
Infusion site reaction 32.16 10.22 156 361776 18883 90247632
Truncus arteriosus persistent 32.10 10.22 20 361912 381 90266134
Heart rate increased 32.06 10.22 292 361640 112610 90153905
Mydriasis 32.05 10.22 10 361922 15002 90251513
Aphasia 31.62 10.22 285 361647 42527 90223988
Lymphadenopathy 31.22 10.22 87 361845 45688 90220827
Interstitial lung disease 31.22 10.22 178 361754 76227 90190288
Urosepsis 30.99 10.22 167 361765 21065 90245450
Full blood count decreased 30.96 10.22 44 361888 29645 90236870
Hypervolaemia 30.85 10.22 52 361880 32705 90233810
Hepatic cirrhosis 30.72 10.22 387 361545 62866 90203649
Bone pain 30.71 10.22 135 361797 61848 90204667
Infusion site swelling 30.62 10.22 5 361927 11715 90254800
Oropharyngeal pain 30.54 10.22 303 361629 114884 90151631
Rectal haemorrhage 30.43 10.22 482 361450 82262 90184253
Asthenia 30.34 10.22 2500 359432 531251 89735264
Therapy partial responder 30.33 10.22 26 361906 22017 90244498
Drug tolerance decreased 30.26 10.22 226 361706 31904 90234611
Pemphigoid 30.25 10.22 92 361840 8934 90257581
Blood creatine increased 30.23 10.22 78 361854 6889 90259626
Drug dose omission by device 30.03 10.22 3 361929 10228 90256287
Throat irritation 30.01 10.22 97 361835 48598 90217917
Spinal operation 29.90 10.22 3 361929 10193 90256322
Tooth disorder 29.61 10.22 49 361883 31041 90235474
Anhedonia 29.60 10.22 5 361927 11426 90255089
Glomerular filtration rate decreased 29.51 10.22 140 361792 16792 90249723
Middle insomnia 29.47 10.22 15 361917 16736 90249779
Nervousness 29.44 10.22 57 361875 33999 90232516
Acute respiratory distress syndrome 29.43 10.22 43 361889 28643 90237872
Product use issue 29.41 10.22 1605 360327 328314 89938201
Blood bilirubin increased 29.37 10.22 83 361849 43387 90223128
Hypertension 29.28 10.22 2163 359769 455369 89811146
Exposure via skin contact 29.28 10.22 4 361928 10701 90255814
Vaginal discharge 29.25 10.22 21 361911 19443 90247072
Burning sensation 29.18 10.22 142 361790 63310 90203205
Walking aid user 29.17 10.22 242 361690 35264 90231251
Product administration interrupted 29.14 10.22 7 361925 12485 90254030
Hepatic enzyme increased 29.09 10.22 1739 360193 358997 89907518
Haematoma 28.87 10.22 260 361672 38788 90227727
Hip arthroplasty 28.82 10.22 446 361486 75762 90190753
Infusion site pain 28.75 10.22 22 361910 19716 90246799
Neoplasm progression 28.56 10.22 87 361845 44399 90222116
Pancreatic neuroendocrine tumour 28.47 10.22 22 361910 600 90265915
Kidney infection 28.44 10.22 37 361895 25879 90240636
Cardiac disorder 28.09 10.22 124 361808 56748 90209767
Hysterectomy 28.01 10.22 6 361926 11578 90254937
Pneumocystis jirovecii pneumonia 27.95 10.22 27 361905 21589 90244926
Complication associated with device 27.92 10.22 22 361910 19427 90247088
Insurance issue 27.92 10.22 5 361927 10953 90255562
Metastases to central nervous system 27.60 10.22 18 361914 17524 90248991
Labile hypertension 27.55 10.22 20 361912 495 90266020
Peripheral circulatory failure 27.50 10.22 33 361899 1571 90264944
Fall 27.25 10.22 2256 359676 479554 89786961
Intestinal haemorrhage 27.23 10.22 57 361875 4390 90262125
Vomiting 27.21 10.22 3569 358363 784724 89481791
Hypoaesthesia 26.91 10.22 1523 360409 312687 89953828
Amnesia 26.70 10.22 594 361338 107911 90158604
Feeling jittery 26.70 10.22 14 361918 15357 90251158
Pelvic pain 26.65 10.22 14 361918 15343 90251172
Chronic obstructive pulmonary disease 26.53 10.22 179 361753 73650 90192865
Impaired quality of life 26.49 10.22 32 361900 23112 90243403
Lupus-like syndrome 26.41 10.22 305 361627 48541 90217974
Hyperhidrosis 26.39 10.22 384 361548 135921 90130594
Oral pain 26.31 10.22 57 361875 32626 90233889
Encephalopathy 26.27 10.22 96 361836 46348 90220167
Pre-existing condition improved 26.11 10.22 3 361929 9166 90257349
Musculoskeletal disorder 26.10 10.22 29 361903 21740 90244775
Swollen joint count 26.07 10.22 85 361847 8568 90257947
Skin infection 25.91 10.22 20 361912 17844 90248671
Intervertebral disc protrusion 25.77 10.22 43 361889 27153 90239362
Epstein-Barr virus infection 25.75 10.22 5 361927 10339 90256176
Cerebral ischaemia 25.69 10.22 75 361857 7121 90259394
Blood calcium decreased 25.68 10.22 51 361881 30131 90236384
Blood cholesterol decreased 25.65 10.22 35 361897 1896 90264619
Chest pain 25.59 10.22 1540 360392 318105 89948410
Therapeutic drug monitoring analysis not performed 25.56 10.22 29 361903 1300 90265215
Psychotic disorder 25.52 10.22 54 361878 31176 90235339
Haemophagocytic lymphohistiocytosis 25.52 10.22 15 361917 15444 90251071
Haemoglobin decreased 25.50 10.22 474 361458 161482 90105033
Stupor 25.49 10.22 63 361869 5419 90261096
Hepatic enzyme 25.47 10.22 62 361870 5282 90261233
Muscle spasms 25.42 10.22 1240 360692 250643 90015872
Bronchopulmonary aspergillosis 25.42 10.22 7 361925 11391 90255124
Thrombocytopenia 25.30 10.22 637 361295 208088 90058427
Adverse reaction 25.21 10.22 204 361728 29508 90237007
Lymphocyte count decreased 25.12 10.22 65 361867 34985 90231530
Dysgeusia 25.12 10.22 116 361816 52444 90214071
Hemianopia 25.07 10.22 36 361896 2046 90264469
Abdominal discomfort 24.95 10.22 2222 359710 475106 89791409
Gastrointestinal disorder 24.94 10.22 1259 360673 255428 90011087
Hypogammaglobulinaemia 24.87 10.22 6 361926 10668 90255847
Troponin I increased 24.85 10.22 40 361892 2515 90264000
Transfusion 24.83 10.22 20 361912 17468 90249047
Hypercreatininaemia 24.79 10.22 22 361910 731 90265784
Anuria 24.73 10.22 121 361811 14697 90251818
Atelectasis 24.64 10.22 37 361895 24372 90242143
Basal ganglia haemorrhage 24.59 10.22 22 361910 739 90265776
Hypoaesthesia oral 24.55 10.22 16 361916 15584 90250931
Upper-airway cough syndrome 24.54 10.22 15 361917 15120 90251395
Pneumonia 24.53 10.22 2204 359728 635855 89630660
Upper limb fracture 24.52 10.22 30 361902 21548 90244967
Foetal growth restriction 24.51 10.22 4 361928 9376 90257139
Neuralgia 24.48 10.22 56 361876 31444 90235071
Posterior reversible encephalopathy syndrome 24.41 10.22 32 361900 22307 90244208
Neuroglycopenia 24.33 10.22 26 361906 1089 90265426
Abnormal loss of weight 24.25 10.22 71 361861 6752 90259763
Generalised tonic-clonic seizure 24.05 10.22 66 361866 34837 90231678
Bradyphrenia 24.04 10.22 76 361856 7536 90258979
Limb reduction defect 24.03 10.22 20 361912 608 90265907
Cough 24.03 10.22 1216 360716 367746 89898769
Cholecystitis chronic 23.94 10.22 5 361927 9821 90256694
Heavy menstrual bleeding 23.91 10.22 28 361904 20502 90246013
Bone erosion 23.90 10.22 320 361612 52701 90213814
Vitamin D decreased 23.81 10.22 9 361923 11970 90254545
Septic shock 23.74 10.22 218 361714 83942 90182573
Fear of injection 23.72 10.22 3 361929 8512 90258003
Body height decreased 23.71 10.22 9 361923 11940 90254575
Sleep disorder due to general medical condition, hypersomnia type 23.66 10.22 35 361897 2044 90264471
Congenital cardiovascular anomaly 23.64 10.22 18 361914 480 90266035
Sputum discoloured 23.55 10.22 28 361904 20363 90246152
Increased tendency to bruise 23.52 10.22 9 361923 11881 90254634
Premature delivery 23.35 10.22 78 361854 38684 90227831
Skin lesion 23.33 10.22 74 361858 37291 90229224
Post procedural complication 23.24 10.22 25 361907 19017 90247498
Intentional overdose 23.16 10.22 251 361681 93583 90172932
Inappropriate antidiuretic hormone secretion 23 10.22 145 361787 19360 90247155
Patent ductus arteriosus 22.84 10.22 54 361878 4515 90262000
Hypomania 22.80 10.22 4 361928 8893 90257622
Device stimulation issue 22.78 10.22 9 361923 59 90266456
Gastroenteritis clostridial 22.78 10.22 20 361912 655 90265860
International normalised ratio increased 22.77 10.22 289 361643 47027 90219488
Metastases to bone 22.65 10.22 42 361890 25463 90241052
Decreased activity 22.55 10.22 3 361929 8189 90258326
Device leakage 22.53 10.22 6 361926 9985 90256530
Body temperature increased 22.38 10.22 97 361835 44613 90221902
Hypersomnia 22.36 10.22 32 361900 21499 90245016
Hereditary angioedema 22.34 10.22 5 361927 9360 90257155
Cytopenia 22.32 10.22 22 361910 17427 90249088
Limb injury 22.15 10.22 59 361873 31449 90235066
Toothache 22.15 10.22 34 361898 22196 90244319
Bone density decreased 22.04 10.22 22 361910 17323 90249192
Dysmorphism 22.03 10.22 38 361894 2530 90263985
Malnutrition 21.95 10.22 25 361907 18533 90247982
Tooth infection 21.93 10.22 29 361903 20141 90246374
Suicide attempt 21.84 10.22 194 361738 75205 90191310
Mitral valve atresia 21.83 10.22 7 361925 22 90266493
Creatinine renal clearance decreased 21.77 10.22 26 361906 18873 90247642
Back disorder 21.76 10.22 176 361756 25455 90241060
Foot fracture 21.75 10.22 46 361886 26560 90239955
Aplastic anaemia 21.73 10.22 13 361919 13256 90253259
Haemorrhage 21.66 10.22 175 361757 69194 90197321
Cystitis noninfective 21.59 10.22 27 361905 1342 90265173
Hypoglycaemic coma 21.52 10.22 41 361891 2949 90263566
Emotional disorder 21.49 10.22 17 361915 14980 90251535
Pneumothorax 21.41 10.22 27 361905 19140 90247375
Bone marrow failure 21.41 10.22 62 361870 32159 90234356
Disability 21.40 10.22 253 361679 40492 90226023
Sleep disorder due to general medical condition, insomnia type 21.37 10.22 669 361263 128025 90138490
Myalgia 21.35 10.22 534 361398 174591 90091924
Nausea 21.32 10.22 4009 357923 1106307 89160208
Osteomyelitis 21.24 10.22 50 361882 27796 90238719
Tumour lysis syndrome 21.15 10.22 9 361923 11143 90255372
Arteriosclerosis coronary artery 21.00 10.22 85 361847 9518 90256997
Reduced facial expression 20.89 10.22 37 361895 2516 90263999
Drug-induced liver injury 20.84 10.22 490 361442 89828 90176687
Leukopenia 20.81 10.22 280 361652 100430 90166085
Deep vein thrombosis 20.69 10.22 250 361682 91370 90175145
Premature labour 20.67 10.22 14 361918 13362 90253153
Knee arthroplasty 20.66 10.22 456 361476 82726 90183789
Aspartate aminotransferase increased 20.63 10.22 288 361644 102649 90163866
Eye injury 20.60 10.22 93 361839 10927 90255588
Overlap syndrome 20.59 10.22 78 361854 8470 90258045
Skin fissures 20.57 10.22 32 361900 20777 90245738
Hydronephrosis 20.52 10.22 12 361920 12390 90254125
Pneumonia viral 20.47 10.22 5 361927 8818 90257697
Anger 20.36 10.22 15 361917 13705 90252810
Hypertensive angiopathy 20.34 10.22 9 361923 81 90266434
Mood swings 20.31 10.22 32 361900 20670 90245845
Pneumonia bacterial 20.29 10.22 13 361919 12777 90253738
Diabetes mellitus inadequate control 20.26 10.22 136 361796 18548 90247967
Lip oedema 20.20 10.22 52 361880 4587 90261928
Respiratory tract inflammation 20.18 10.22 18 361914 602 90265913
Pollakiuria 20.16 10.22 66 361866 32939 90233576
Limb hypoplasia congenital 20.10 10.22 12 361920 211 90266304
Anti-cyclic citrullinated peptide antibody 19.99 10.22 181 361751 27040 90239475
Blood test abnormal 19.97 10.22 33 361899 20919 90245596
Emotional distress 19.94 10.22 77 361855 36585 90229930
Hypophosphataemia 19.86 10.22 18 361914 14836 90251679
Metastases to lymph nodes 19.78 10.22 11 361921 11678 90254837
Pulmonary hypertension 19.65 10.22 95 361837 42428 90224087
Infection 19.60 10.22 1215 360717 360879 89905636
Faecal vomiting 19.59 10.22 20 361912 794 90265721
Conjunctivitis 19.55 10.22 49 361883 26657 90239858
Hypothyroidism 19.49 10.22 128 361804 52999 90213516
Gingival hypertrophy 19.46 10.22 33 361899 2167 90264348
Delusion 19.44 10.22 16 361916 13824 90252691
Scleroedema 19.40 10.22 10 361922 130 90266385
Rectal polyp 19.25 10.22 23 361909 1090 90265425
Drug abuse 19.25 10.22 223 361709 82124 90184391
Congenital aortic valve stenosis 19.22 10.22 8 361924 61 90266454
Left ventricular dysfunction 19.17 10.22 112 361820 14557 90251958
Fear 19.01 10.22 23 361909 16599 90249916
Heart rate irregular 18.98 10.22 43 361889 24225 90242290
Myelodysplastic syndrome 18.94 10.22 34 361898 20869 90245646
Photophobia 18.91 10.22 35 361897 21234 90245281
Tumour invasion 18.88 10.22 13 361919 295 90266220
Nasopharyngitis 18.86 10.22 1879 360053 405225 89861290
Small intestinal obstruction 18.83 10.22 35 361897 21199 90245316
Crying 18.81 10.22 47 361885 25598 90240917
Pallor 18.77 10.22 214 361718 33951 90232564
Cushingoid 18.76 10.22 9 361923 10386 90256129
Pulmonary embolism 18.74 10.22 389 361543 130431 90136084
Lymphoma 18.74 10.22 16 361916 13575 90252940
Adverse event 18.61 10.22 607 361325 116811 90149704
Osteonecrosis 18.55 10.22 49 361883 26192 90240323
Compression fracture 18.50 10.22 6 361926 8783 90257732
Pancreatitis acute 18.48 10.22 203 361729 31912 90234603
Eye pruritus 18.46 10.22 57 361875 28970 90237545
Congestive cardiomyopathy 18.46 10.22 68 361864 7286 90259229
Acute hepatic failure 18.45 10.22 39 361893 22522 90243993
Excessive eye blinking 18.43 10.22 25 361907 1347 90265168
Hepatorenal failure 18.38 10.22 18 361914 679 90265836
Pulmonary thrombosis 18.38 10.22 8 361924 9774 90256741
Pericardial effusion 18.38 10.22 80 361852 36753 90229762
Sleep apnoea syndrome 18.36 10.22 65 361867 31682 90234833
Withdrawal syndrome 18.36 10.22 39 361893 22485 90244030
Spinal disorder 18.35 10.22 12 361920 11667 90254848
Gastrointestinal pain 18.32 10.22 11 361921 11195 90255320
Congenital renal cyst 18.29 10.22 5 361927 7 90266508
Central nervous system lesion 18.25 10.22 12 361920 11634 90254881
Rotator cuff syndrome 18.23 10.22 22 361910 15897 90250618
Paraesthesia oral 18.19 10.22 65 361867 31594 90234921
Hospice care 18.13 10.22 8 361924 9696 90256819
Parkinsonism 18.13 10.22 107 361825 13958 90252557
Arrhythmia 18.07 10.22 253 361679 42079 90224436
Hepatic encephalopathy 18.04 10.22 17 361915 13755 90252760
Abnormal clotting factor 18.02 10.22 9 361923 109 90266406
Psychogenic tremor 18.01 10.22 6 361926 22 90266493
Concussion 17.97 10.22 11 361921 11080 90255435
Congenital choroid plexus cyst 17.76 10.22 13 361919 326 90266189
Impaired gastric emptying 17.75 10.22 15 361917 12794 90253721
Pruritus genital 17.73 10.22 49 361883 4509 90262006
Mucosal inflammation 17.70 10.22 146 361786 57479 90209036
Stillbirth 17.70 10.22 4 361928 7439 90259076
Major depression 17.64 10.22 9 361923 10026 90256489
Congenital oral malformation 17.59 10.22 11 361921 211 90266304
Colon cancer 17.53 10.22 11 361921 10933 90255582
Cardiac failure chronic 17.49 10.22 56 361876 5590 90260925
Poisoning 17.46 10.22 21 361911 15196 90251319
Basilar artery thrombosis 17.42 10.22 10 361922 163 90266352
Duodenal ulcer 17.40 10.22 80 361852 9472 90257043
Disorientation 17.38 10.22 260 361672 43854 90222661
Noninfective gingivitis 17.35 10.22 31 361901 2122 90264393
Talipes 17.30 10.22 27 361905 1653 90264862
Bronchomalacia 17.27 10.22 11 361921 218 90266297
Feeding disorder 17.24 10.22 27 361905 17485 90249030
Polyarthritis 17.24 10.22 129 361803 18221 90248294
Liver disorder 17.23 10.22 619 361313 120650 90145865
Oral dysaesthesia 17.13 10.22 9 361923 122 90266393
Rebound effect 17.12 10.22 8 361924 9376 90257139
Tachyarrhythmia 17.10 10.22 54 361878 5352 90261163
Mesenteric arterial occlusion 16.94 10.22 10 361922 172 90266343
Tenderness 16.92 10.22 53 361879 26815 90239700
Leukocytosis 16.91 10.22 65 361867 30925 90235590
Listless 16.90 10.22 39 361893 3210 90263305
Blood osmolarity abnormal 16.86 10.22 5 361927 11 90266504
Chest wall haematoma 16.84 10.22 11 361921 228 90266287
Traumatic intracranial haemorrhage 16.83 10.22 17 361915 666 90265849
Sarcoidosis 16.73 10.22 11 361921 10662 90255853
Hypertensive emergency 16.70 10.22 31 361901 2186 90264329
Decreased immune responsiveness 16.68 10.22 7 361925 8741 90257774
Tooth dislocation 16.53 10.22 6 361926 30 90266485
Urogenital infection fungal 16.53 10.22 6 361926 30 90266485
Prerenal failure 16.47 10.22 30 361902 2085 90264430
Eating disorder 16.41 10.22 178 361754 27895 90238620
Sinus headache 16.40 10.22 3 361929 6473 90260042
Bronchiectasis 16.32 10.22 41 361891 22289 90244226
Nervous system disorder 16.29 10.22 39 361893 21554 90244961
Menstruation irregular 16.11 10.22 6 361926 8054 90258461
Intestinal perforation 16.09 10.22 19 361913 13862 90252653
Small fibre neuropathy 16.01 10.22 17 361915 707 90265808
Eye infection 16.01 10.22 20 361912 14234 90252281
Palmoplantar keratoderma 15.98 10.22 40 361892 3467 90263048
Femur fracture 15.93 10.22 113 361819 45969 90220546
Papule 15.92 10.22 6 361926 7996 90258519
Amenorrhoea 15.92 10.22 14 361918 11708 90254807
Bipolar disorder 15.88 10.22 8 361924 8977 90257538
Intervertebral disc degeneration 15.74 10.22 28 361904 17246 90249269
Splenomegaly 15.74 10.22 17 361915 12907 90253608
Electrocardiogram abnormal 15.72 10.22 82 361850 10216 90256299
Vaginal infection 15.70 10.22 7 361925 8433 90258082
Hypovolaemic shock 15.68 10.22 63 361869 7031 90259484
Gout 15.66 10.22 27 361905 16832 90249683
Sensitivity to weather change 15.66 10.22 8 361924 8906 90257609
Scoliosis 15.64 10.22 8 361924 8899 90257616
Hypercapnic coma 15.52 10.22 11 361921 262 90266253
Foot deformity 15.45 10.22 329 361603 59322 90207193
Acute respiratory failure 15.45 10.22 104 361828 42814 90223701
Product blister packaging issue 15.44 10.22 12 361920 330 90266185
Mood altered 15.43 10.22 28 361904 17116 90249399
Cardiospasm 15.39 10.22 39 361893 3407 90263108
Jaundice hepatocellular 15.36 10.22 6 361926 38 90266477
Therapy change 15.33 10.22 7 361925 8315 90258200
Febrile bone marrow aplasia 15.31 10.22 10 361922 9728 90256787
Hyperlipidaemia 15.30 10.22 44 361888 22872 90243643
Respiratory distress 15.23 10.22 92 361840 38854 90227661
Antinuclear antibody positive 15.21 10.22 9 361923 9232 90257283
Hypoalbuminaemia 15.19 10.22 25 361907 15872 90250643
Sinus congestion 15.16 10.22 172 361760 27252 90239263
Cardiovascular insufficiency 15.09 10.22 25 361907 1610 90264905
Bundle branch block left 15.08 10.22 67 361865 7818 90258697
Acute coronary syndrome 15.08 10.22 84 361848 10729 90255786
Sneezing 15.04 10.22 184 361748 29685 90236830
Dental caries 15.01 10.22 14 361918 11383 90255132
Blood lactic acid 15.00 10.22 8 361924 112 90266403
Bone disorder 14.99 10.22 45 361887 23075 90243440
Breast cancer stage I 14.97 10.22 10 361922 9614 90256901
Fracture blisters 14.93 10.22 7 361925 73 90266442
Alopecia 14.90 10.22 2224 359708 492847 89773668
Cardiac septal defect 14.88 10.22 17 361915 768 90265747
Injection site irritation 14.78 10.22 3 361929 6012 90260503
Dysstasia 14.69 10.22 51 361881 25001 90241514
Cerebral haemorrhage 14.60 10.22 206 361726 34316 90232199
Haemorrhoids 14.57 10.22 56 361876 26646 90239869
Serotonin syndrome 14.56 10.22 90 361842 37797 90228718
Heat stroke 14.53 10.22 18 361914 886 90265629
Gastrointestinal toxicity 14.51 10.22 10 361922 9457 90257058
Stoma site haemorrhage 14.48 10.22 22 361910 1316 90265199
Erysipelas 14.46 10.22 73 361859 8979 90257536
Pneumonia fungal 14.45 10.22 5 361927 7026 90259489
Infusion site extravasation 14.43 10.22 12 361920 10316 90256199
Pneumonia herpes viral 14.39 10.22 6 361926 46 90266469
Irregular sleep wake rhythm disorder 14.33 10.22 10 361922 232 90266283
Enthesopathy 14.32 10.22 10 361922 9394 90257121
Liver function test increased 14.32 10.22 442 361490 84413 90182102
Mouth ulceration 14.32 10.22 97 361835 39877 90226638
Mucosal dryness 14.31 10.22 36 361896 3131 90263384
Glucose tolerance impaired 14.28 10.22 7 361925 7978 90258537
SARS-CoV-2 test positive 14.27 10.22 14 361918 11114 90255401
Therapy non-responder 14.20 10.22 675 361257 136029 90130486
Accident 14.20 10.22 5 361927 6949 90259566
Viral infection 14.10 10.22 102 361830 41312 90225203
Autoimmune blistering disease 14.09 10.22 4 361928 7 90266508
Visceral congestion 14.06 10.22 12 361920 378 90266137
Tumour marker increased 14.06 10.22 3 361929 5804 90260711
Crepitations 14.04 10.22 9 361923 8843 90257672
Eczema 14.04 10.22 139 361793 52731 90213784
Dilatation ventricular 14.02 10.22 30 361902 2346 90264169
Underdose 14.02 10.22 298 361634 53719 90212796
Blood urine present 14.02 10.22 30 361902 17248 90249267
Electrocardiogram repolarisation abnormality 14.01 10.22 22 361910 1354 90265161
Scar 13.99 10.22 25 361907 15370 90251145
Dermatitis acneiform 13.99 10.22 4 361928 6350 90260165
Food interaction 13.99 10.22 21 361911 1243 90265272
Blood creatine phosphokinase increased 13.98 10.22 202 361730 33821 90232694
Pancreatitis necrotising 13.98 10.22 30 361902 2351 90264164
Device occlusion 13.97 10.22 10 361922 9272 90257243
Acquired diaphragmatic eventration 13.96 10.22 14 361918 544 90265971
Scab 13.95 10.22 11 361921 9710 90256805
Cardiac valve sclerosis 13.94 10.22 5 361927 24 90266491
Disseminated intravascular coagulation 13.91 10.22 42 361890 21496 90245019
Mental disorder 13.91 10.22 74 361858 32244 90234271
Nerve compression 13.89 10.22 13 361919 10553 90255962
Lung neoplasm malignant 13.84 10.22 50 361882 24223 90242292
Retrognathia 13.83 10.22 14 361918 550 90265965
Optic neuritis 13.83 10.22 11 361921 9667 90256848
Drug-disease interaction 13.82 10.22 18 361914 932 90265583
Blood magnesium decreased 13.80 10.22 26 361906 15667 90250848
Blood immunoglobulin A decreased 13.79 10.22 25 361907 1731 90264784
Varicose vein 13.76 10.22 6 361926 7321 90259194
Thyroid cancer 13.75 10.22 4 361928 6280 90260235
Hepatitis 13.73 10.22 375 361557 70364 90196151
Therapeutic product effect decreased 13.70 10.22 1287 360645 276284 89990231
Respiratory syncytial virus infection 13.65 10.22 13 361919 10467 90256048
Eye discharge 13.65 10.22 8 361924 8250 90258265
Hyponatraemic syndrome 13.63 10.22 14 361918 560 90265955
Anaemia 13.62 10.22 1218 360714 351584 89914931
Normal newborn 13.59 10.22 148 361784 23214 90243301
Hallucination, auditory 13.58 10.22 27 361905 15948 90250567
Frontotemporal dementia 13.51 10.22 12 361920 399 90266116
Immunosuppression 13.51 10.22 17 361915 12060 90254455
Blindness unilateral 13.50 10.22 7 361925 7729 90258786
Swelling 13.50 10.22 1890 360042 417168 89849347
Visual acuity reduced 13.49 10.22 48 361884 23362 90243153
Right ventricular failure 13.47 10.22 36 361896 19169 90247346
Skin papilloma 13.44 10.22 3 361929 5627 90260888
Brain stem stroke 13.34 10.22 12 361920 406 90266109
Bundle branch block right 13.34 10.22 50 361882 5403 90261112
Panic attack 13.32 10.22 57 361875 26308 90240207
Drug dependence 13.27 10.22 66 361866 29261 90237254
Diabetic retinal oedema 13.24 10.22 12 361920 410 90266105
Cyst 13.23 10.22 29 361903 16532 90249983
Rash macular 13.22 10.22 69 361863 30211 90236304
Skin necrosis 13.14 10.22 114 361818 16827 90249688
Nerve injury 13.09 10.22 15 361917 11091 90255424
Atrial tachycardia 13.09 10.22 53 361879 5937 90260578
Pneumonitis 13.08 10.22 113 361819 44057 90222458
Cystitis haemorrhagic 13.04 10.22 3 361929 5510 90261005
Respiratory tract congestion 13.01 10.22 167 361765 27243 90239272
Arthritis 12.98 10.22 804 361128 166511 90100004
Granuloma skin 12.97 10.22 80 361852 10600 90255915
Injection site warmth 12.93 10.22 32 361900 17483 90249032
Erythema multiforme 12.92 10.22 18 361914 12228 90254287
Dermatitis exfoliative 12.91 10.22 50 361882 5486 90261029
Caesarean section 12.90 10.22 35 361897 18542 90247973
Peripartum cardiomyopathy 12.89 10.22 9 361923 209 90266306
Acute myeloid leukaemia 12.80 10.22 41 361891 20599 90245916
Pulmonary alveolar haemorrhage 12.80 10.22 4 361928 5994 90260521
Endoscopic retrograde cholangiopancreatography 12.78 10.22 9 361923 212 90266303
Jugular vein occlusion 12.76 10.22 6 361926 63 90266452
Alanine aminotransferase abnormal 12.74 10.22 3 361929 5423 90261092
Spinal stenosis 12.73 10.22 32 361900 17392 90249123
Blood immunoglobulin M increased 12.69 10.22 21 361911 1351 90265164
Tuberculosis 12.69 10.22 19 361913 12530 90253985
Infusion site haemorrhage 12.69 10.22 3 361929 5408 90261107
Synovial cyst 12.67 10.22 17 361915 11735 90254780
Purulent discharge 12.67 10.22 3 361929 5402 90261113
Pigmentation disorder 12.63 10.22 4 361928 5945 90260570
Eosinophil cationic protein increased 12.60 10.22 6 361926 65 90266450
Skin mass 12.56 10.22 7 361925 7423 90259092
Coma scale abnormal 12.47 10.22 50 361882 5576 90260939
Paresis 12.42 10.22 31 361901 2683 90263832
Hypoacusis 12.42 10.22 63 361869 27787 90238728
Colitis erosive 12.39 10.22 9 361923 223 90266292
Eosinophilia 12.37 10.22 171 361761 28362 90238153
Haemoptysis 12.36 10.22 80 361852 33240 90233275
Peripheral swelling 12.33 10.22 1855 360077 411251 89855264
Ocular discomfort 12.31 10.22 5 361927 6365 90260150
Cerebral artery occlusion 12.30 10.22 18 361914 1041 90265474
Renal artery stenosis 12.29 10.22 27 361905 2150 90264365
Streptococcal infection 12.27 10.22 7 361925 7326 90259189
Skin hyperpigmentation 12.26 10.22 6 361926 6845 90259670
Oral infection 12.24 10.22 3 361929 5277 90261238
Maternal exposure during pregnancy 12.22 10.22 1629 360303 358434 89908081
Musculoskeletal chest pain 12.21 10.22 51 361881 23699 90242816
Oral disorder 12.17 10.22 14 361918 10331 90256184
Cerebral ventricle collapse 12.14 10.22 5 361927 37 90266478
Intracranial pressure increased 12.13 10.22 6 361926 6805 90259710
Aphonia 12.12 10.22 19 361913 12300 90254215
Ear pruritus 12.11 10.22 6 361926 6797 90259718
Urinary retention 12.09 10.22 215 361717 37529 90228986
Disease risk factor 12.08 10.22 9 361923 232 90266283
Immune system disorder 12.06 10.22 18 361914 11887 90254628
Immune effector cell-associated neurotoxicity syndrome 12.03 10.22 4 361928 5764 90260751
Meningitis aseptic 12.01 10.22 6 361926 6767 90259748
Pneumonia aspiration 12.00 10.22 105 361827 40835 90225680
Paralysis 11.98 10.22 17 361915 11461 90255054
Metastases to lung 11.97 10.22 29 361903 15962 90250553
Nystagmus 11.95 10.22 7 361925 7220 90259295
Macrophage activation 11.94 10.22 4 361928 15 90266500
Burning feet syndrome 11.93 10.22 7 361925 119 90266396
Melanocytic naevus 11.92 10.22 3 361929 5183 90261332
Pathogen resistance 11.88 10.22 9 361923 8106 90258409
Peripheral arterial occlusive disease 11.83 10.22 43 361889 4578 90261937
Malignant melanoma 11.81 10.22 20 361912 12556 90253959
Product adhesion issue 11.77 10.22 3 361929 5139 90261376
Secretion discharge 11.76 10.22 29 361903 15867 90250648
Apathy 11.76 10.22 80 361852 10960 90255555
Bradykinesia 11.74 10.22 56 361876 6732 90259783
Skin disorder 11.74 10.22 92 361840 36614 90229901
Herpes simplex 11.73 10.22 14 361918 10167 90256348
Hepatitis C 11.68 10.22 4 361928 5656 90260859
Meningitis 11.67 10.22 10 361922 8471 90258044
Rheumatic disorder 11.67 10.22 35 361897 3373 90263142
Senile dementia 11.66 10.22 9 361923 245 90266270
Psychiatric symptom 11.62 10.22 7 361925 7111 90259404
Large intestine perforation 11.58 10.22 13 361919 9699 90256816
Gastrointestinal ischaemia 11.49 10.22 8 361924 185 90266330
Failure to thrive 11.47 10.22 10 361922 8401 90258114
Gingival swelling 11.47 10.22 45 361887 4968 90261547
Osteopenia 11.45 10.22 50 361882 22952 90243563
Iliac artery occlusion 11.44 10.22 9 361923 252 90266263
Traumatic haemorrhage 11.43 10.22 13 361919 584 90265931
Thrombotic microangiopathy 11.43 10.22 29 361903 15714 90250801
Electrocardiogram QT shortened 11.34 10.22 8 361924 189 90266326
Ingrowing nail 11.33 10.22 31 361901 2836 90263679
Rabbit syndrome 11.33 10.22 10 361922 330 90266185
Blood alkaline phosphatase increased 11.31 10.22 130 361802 47949 90218566
Metabolic disorder 11.30 10.22 8 361924 7462 90259053
Ascites 11.27 10.22 129 361803 47611 90218904
Lip blister 11.25 10.22 31 361901 2847 90263668
Eyelid bleeding 11.21 10.22 5 361927 46 90266469
Gouty tophus 11.21 10.22 9 361923 260 90266255
Pleural effusion 11.20 10.22 351 361581 111640 90154875
Phlebitis 11.19 10.22 8 361924 7422 90259093
Wrist fracture 11.18 10.22 29 361903 15595 90250920
Hypothermia 11.15 10.22 103 361829 15472 90251043
Pseudomonas infection 11.09 10.22 27 361905 14838 90251677
Lacrimation increased 11.08 10.22 63 361869 26999 90239516
Failure to suspend medication 11.07 10.22 6 361926 87 90266428
Palmar-plantar erythrodysaesthesia syndrome 11.06 10.22 66 361866 27957 90238558
Gamma-glutamyltransferase increased 11.05 10.22 213 361719 37739 90228776
Gastrointestinal angiodysplasia 11.03 10.22 13 361919 607 90265908
Injection site haematoma 11.03 10.22 7 361925 6915 90259600
Dyskinesia 11.02 10.22 93 361839 36441 90230074
Anal paraesthesia 11.02 10.22 4 361928 20 90266495
Treatment noncompliance 10.98 10.22 143 361789 51584 90214931
Blood parathyroid hormone decreased 10.98 10.22 85 361847 12131 90254384
Anaphylactoid shock 10.98 10.22 11 361921 427 90266088
Nephrosclerosis 10.96 10.22 18 361914 1151 90265364
Asthma-chronic obstructive pulmonary disease overlap syndrome 10.94 10.22 3 361929 4896 90261619
Muscle contractions involuntary 10.92 10.22 31 361901 2897 90263618
Viral upper respiratory tract infection 10.91 10.22 11 361921 8623 90257892
Blood iron decreased 10.91 10.22 36 361896 17923 90248592
Tender joint count 10.87 10.22 20 361912 1401 90265114
Hordeolum 10.87 10.22 3 361929 4875 90261640
Myoglobinaemia 10.86 10.22 4 361928 21 90266494
Haematotoxicity 10.82 10.22 21 361911 12514 90254001
Crohn's disease 10.78 10.22 3 361929 4848 90261667
Procedural complication 10.74 10.22 5 361927 5873 90260642
Arterial stenosis 10.72 10.22 14 361918 727 90265788
Multiple lentigines syndrome 10.71 10.22 8 361924 207 90266308
Hypertelorism 10.68 10.22 12 361920 532 90265983
Eosinophil count increased 10.66 10.22 89 361843 12992 90253523
Skin warm 10.66 10.22 9 361923 7678 90258837
Dialysis 10.65 10.22 18 361914 11311 90255204
Thunderclap headache 10.65 10.22 10 361922 358 90266157
Tardive dyskinesia 10.62 10.22 17 361915 10913 90255602
Viral diarrhoea 10.62 10.22 8 361924 210 90266305
Loose tooth 10.59 10.22 36 361896 3707 90262808
Blood calcium increased 10.58 10.22 20 361912 12038 90254477
Burns second degree 10.55 10.22 24 361908 1956 90264559
Vascular access complication 10.45 10.22 27 361905 2386 90264129
Adrenocortical carcinoma 10.43 10.22 5 361927 55 90266460
Atrioventricular block complete 10.39 10.22 71 361861 9740 90256775
Brain stem infarction 10.36 10.22 15 361917 859 90265656
Erythrodermic psoriasis 10.33 10.22 17 361915 1089 90265426
Micturition disorder 10.33 10.22 31 361901 2989 90263526
Oedema due to hepatic disease 10.31 10.22 3 361929 6 90266509
Angina unstable 10.30 10.22 56 361876 7087 90259428
Diffuse vasculitis 10.28 10.22 4 361928 25 90266490
Genital paraesthesia 10.28 10.22 4 361928 25 90266490
Gastric cyst 10.28 10.22 6 361926 101 90266414
Vitreous floaters 10.27 10.22 9 361923 7540 90258975
BRASH syndrome 10.27 10.22 23 361909 1856 90264659
Erythema nodosum 10.26 10.22 5 361927 5719 90260796
Skin neoplasm excision 10.25 10.22 22 361910 1724 90264791
Sensory level abnormal 10.24 10.22 7 361925 157 90266358

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 739.38 10.69 3411 186438 363926 42067560
Death 573.61 10.69 758 189091 470427 41961059
Drug ineffective 476.72 10.69 1347 188502 628850 41802636
Angioedema 466.08 10.69 745 189104 41732 42389754
General physical health deterioration 449.54 10.69 1588 188261 149658 42281828
Hyperkalaemia 413.78 10.69 1027 188822 79431 42352055
Off label use 396.04 10.69 1489 188360 636846 41794640
Syncope 339.44 10.69 1094 188755 98312 42333174
Hypertensive crisis 304.19 10.69 296 189553 9910 42421576
Cardiac failure 244.23 10.69 1033 188816 105823 42325663
Bradycardia 243.69 10.69 886 188963 84598 42346888
Febrile neutropenia 232.93 10.69 291 189558 185412 42246074
Swollen tongue 226.79 10.69 368 189481 20863 42410623
Disease progression 223.39 10.69 187 189662 143469 42288017
Hypotension 222.03 10.69 1929 187920 255702 42175784
Product dose omission issue 218.61 10.69 219 189630 154146 42277340
Angina pectoris 206.19 10.69 454 189395 32442 42399044
Drug interaction 205.54 10.69 1951 187898 265048 42166438
Product prescribing error 202.01 10.69 393 189456 25719 42405767
Presyncope 198.20 10.69 357 189492 22030 42409456
Completed suicide 197.74 10.69 91 189758 96374 42335112
Toxicity to various agents 185.43 10.69 472 189377 228664 42202822
Platelet count decreased 174.90 10.69 216 189633 138365 42293121
Dyspnoea 169.37 10.69 2838 187011 439783 41991703
Lip swelling 168.88 10.69 304 189545 18749 42412737
Neutropenia 160.38 10.69 412 189437 199019 42232467
Atrial fibrillation 148.19 10.69 1097 188752 138496 42292990
White blood cell count decreased 141.45 10.69 170 189679 110226 42321260
Haematochezia 140.49 10.69 574 189275 57862 42373624
Ejection fraction decreased 139.72 10.69 306 189543 21781 42409705
Orthostatic hypotension 139.18 10.69 373 189476 30197 42401289
Dizziness 132.88 10.69 1694 188155 247560 42183926
Neuropathy peripheral 132.45 10.69 155 189694 101698 42329788
Drug ineffective for unapproved indication 130.16 10.69 24 189825 46139 42385347
Pneumonia 129.42 10.69 1230 188619 420919 42010567
Tongue oedema 127.85 10.69 111 189738 3199 42428287
Vertigo 123.43 10.69 385 189464 33962 42397524
Lactic acidosis 116.32 10.69 454 189395 44807 42386679
Product use in unapproved indication 115.57 10.69 427 189422 184029 42247457
Oedema peripheral 115.38 10.69 1016 188833 135060 42296426
Circulatory collapse 113.30 10.69 294 189555 23342 42408144
Product monitoring error 107.61 10.69 115 189734 4308 42427178
Hypoglycaemia 105.82 10.69 537 189312 59317 42372169
Hospitalisation 104.49 10.69 106 189743 74224 42357262
Pyrexia 104.36 10.69 1188 188661 392854 42038632
Acute myocardial infarction 102.93 10.69 522 189327 57643 42373843
Hyponatraemia 102.88 10.69 789 189060 100673 42330813
Dyspnoea exertional 101.67 10.69 468 189381 49680 42381806
Coronary artery disease 100.66 10.69 490 189359 53230 42378256
Treatment failure 99.13 10.69 80 189769 62544 42368942
Sopor 98.81 10.69 196 189653 13006 42418480
Rectal haemorrhage 98.40 10.69 460 189389 49146 42382340
Arrhythmia 96.06 10.69 395 189454 39922 42391564
Congenital hiatus hernia 94.83 10.69 127 189722 6047 42425439
Melaena 94.21 10.69 382 189467 38364 42393122
Myocardial infarction 92.05 10.69 900 188949 123109 42308377
Cytomegalovirus infection 90.63 10.69 17 189832 32289 42399197
Hepatojugular reflux 90.50 10.69 49 189800 630 42430856
Fall 88.25 10.69 1501 188348 233019 42198467
Palpitations 86.48 10.69 451 189398 50346 42381140
Cardiac failure chronic 86.11 10.69 154 189695 9447 42422039
Loss of consciousness 85.30 10.69 703 189146 91651 42339835
Drug dependence 84.47 10.69 14 189835 29080 42402406
Palatal oedema 84.02 10.69 54 189795 970 42430516
Ventricular hypokinesia 82.75 10.69 126 189723 6758 42424728
Haematuria 82.30 10.69 489 189360 57310 42374176
Cytokine release syndrome 82.30 10.69 48 189801 44479 42387007
Malignant neoplasm progression 81.70 10.69 231 189618 108169 42323317
Mitral valve incompetence 80.98 10.69 207 189642 16282 42415204
Drug abuse 80.65 10.69 221 189628 104550 42326936
Dyspnoea at rest 80.46 10.69 97 189752 4152 42427334
Hepatic function abnormal 80.22 10.69 67 189782 51500 42379986
Exercise tolerance decreased 80.06 10.69 116 189733 5950 42425536
Acute coronary syndrome 79.73 10.69 193 189656 14672 42416814
Electrolyte imbalance 79.18 10.69 210 189639 16891 42414595
Neutrophil count decreased 78.72 10.69 100 189749 63315 42368171
Ventricular arrhythmia 78.43 10.69 117 189732 6162 42425324
Malignant melanoma in situ 78.25 10.69 78 189771 2689 42428797
Labelled drug-drug interaction medication error 76.92 10.69 196 189653 15386 42416100
Ischaemic stroke 76.92 10.69 246 189603 21987 42409499
Medication error 76.76 10.69 322 189527 32832 42398654
Systemic infection 75.30 10.69 104 189745 5101 42426385
Respiratory failure 74.18 10.69 306 189543 127826 42303660
Left ventricular dysfunction 73.48 10.69 160 189689 11341 42420145
Myalgia 72.09 10.69 699 189150 95381 42336105
Occult blood 71.19 10.69 48 189801 938 42430548
Bronchiectasis 70.37 10.69 208 189641 17811 42413675
Mental status changes 70.22 10.69 51 189798 42064 42389422
Plasma cell myeloma 70.16 10.69 65 189784 47513 42383973
Hypoxia 69.37 10.69 128 189721 69658 42361828
Electrocardiogram abnormal 69.27 10.69 145 189704 10000 42421486
Hypercholesterolaemia 69.10 10.69 167 189682 12682 42418804
Full blood count decreased 66.60 10.69 7 189842 20553 42410933
Erectile dysfunction 66.53 10.69 253 189596 24660 42406826
Cerebral haemorrhage 66.34 10.69 346 189503 38620 42392866
Drug resistance 66.06 10.69 35 189814 34213 42397273
Sinusitis 65.82 10.69 68 189781 47224 42384262
Drug hypersensitivity 64.88 10.69 226 189623 99163 42332323
Systolic dysfunction 63.77 10.69 73 189776 2955 42428531
Rhabdomyolysis 63.21 10.69 577 189272 77442 42354044
No adverse event 62.81 10.69 49 189800 38972 42392514
Confusional state 62.35 10.69 1071 188778 166526 42264960
Rash 61.22 10.69 867 188982 276087 42155399
Benign prostatic hyperplasia 59.72 10.69 218 189631 20834 42410652
Pallor 59.59 10.69 271 189578 28615 42402871
Anxiety 58.59 10.69 300 189549 118260 42313226
Sepsis 57.80 10.69 588 189261 198746 42232740
Electrocardiogram Q wave abnormal 56.17 10.69 33 189816 501 42430985
Tricuspid valve incompetence 56.12 10.69 141 189708 10972 42420514
Urogenital haemorrhage 56.05 10.69 37 189812 697 42430789
Glomerular filtration rate decreased 55.73 10.69 180 189669 16171 42415315
Breath sounds abnormal 55.48 10.69 148 189701 11945 42419541
Coronary artery stenosis 53.79 10.69 133 189716 10246 42421240
Myelosuppression 53.18 10.69 61 189788 40400 42391086
Blood pressure increased 52.97 10.69 690 189159 101238 42330248
Lip oedema 52.78 10.69 68 189781 3116 42428370
Congestive cardiomyopathy 52.69 10.69 119 189730 8645 42422841
COVID-19 52.01 10.69 303 189546 115645 42315841
Musculoskeletal pain 51.31 10.69 288 189561 33052 42398434
Helicobacter gastritis 49.39 10.69 44 189805 1313 42430173
Pancreatitis acute 49.07 10.69 286 189563 33278 42398208
Brain stem stroke 48.80 10.69 26 189823 323 42431163
Blood pressure diastolic decreased 48.63 10.69 128 189721 10247 42421239
Carotid artery stenosis 48.50 10.69 87 189762 5349 42426137
Aspergillus infection 47.38 10.69 7 189842 15830 42415656
Therapy interrupted 47.12 10.69 20 189829 22230 42409256
Product use issue 46.48 10.69 180 189669 76571 42354915
Therapeutic product effect decreased 46.27 10.69 64 189785 39086 42392400
Drug withdrawal syndrome 46.23 10.69 19 189830 21530 42409956
Therapeutic drug monitoring analysis not performed 46.05 10.69 30 189819 552 42430934
Bundle branch block left 45.90 10.69 94 189755 6382 42425104
Transient ischaemic attack 45.82 10.69 282 189567 33457 42398029
International normalised ratio increased 45.70 10.69 369 189480 47799 42383687
Inferior vena cava dilatation 45.51 10.69 34 189815 786 42430700
Bronchopulmonary aspergillosis 45.27 10.69 15 189834 19414 42412072
Drug intolerance 44.71 10.69 195 189654 80229 42351257
Central nervous system mass 44.38 10.69 34 189815 817 42430669
Degenerative mitral valve disease 44.30 10.69 23 189826 270 42431216
Wall motion score index abnormal 44.24 10.69 34 189815 821 42430665
Hemiplegia 44.09 10.69 104 189745 7775 42423711
Bacteraemia 43.49 10.69 29 189820 25011 42406475
Sleep disorder due to a general medical condition 43.33 10.69 12 189837 17441 42414045
Respiratory depression 43.21 10.69 15 189834 18853 42412633
Hyperthyroidism 42.80 10.69 151 189698 14190 42417296
Airway remodelling 42.70 10.69 34 189815 866 42430620
Unevaluable event 42.61 10.69 54 189795 34234 42397252
Potentiating drug interaction 42.48 10.69 91 189758 6377 42425109
Atopy 42.38 10.69 35 189814 940 42430546
Wrong technique in product usage process 41.65 10.69 79 189770 42556 42388930
Computerised tomogram coronary artery abnormal 41.61 10.69 18 189831 135 42431351
Disseminated intravascular coagulation 41.36 10.69 30 189819 24764 42406722
Therapeutic response decreased 41.29 10.69 63 189786 36949 42394537
Therapeutic product effect incomplete 41.28 10.69 169 189680 70770 42360716
Bone marrow failure 41.25 10.69 52 189797 33041 42398445
Staphylococcal infection 41.11 10.69 65 189784 37578 42393908
Dehydration 41.05 10.69 872 188977 140895 42290591
Cholestasis 41.05 10.69 269 189580 32610 42398876
Therapy partial responder 40.82 10.69 19 189830 20002 42411484
Graft versus host disease 40.36 10.69 5 189844 12920 42418566
Stomatitis 40.34 10.69 104 189745 50225 42381261
Catarrh 40.22 10.69 85 189764 5901 42425585
Dry skin 40.21 10.69 98 189751 48240 42383246
Antidepressant drug level above therapeutic 39.97 10.69 21 189828 253 42431233
Hyponatraemic syndrome 39.94 10.69 19 189830 182 42431304
Cardio-respiratory arrest 39.84 10.69 131 189718 58505 42372981
Swelling face 39.77 10.69 234 189615 27320 42404166
Metabolic acidosis 39.71 10.69 379 189470 51479 42380007
Naevus flammeus 39.59 10.69 19 189830 186 42431300
Nocturia 39.18 10.69 131 189718 11981 42419505
Pulmonary alveolar haemorrhage 39.07 10.69 9 189840 14807 42416679
Brain scan abnormal 38.92 10.69 37 189812 1202 42430284
Adverse event 38.92 10.69 29 189820 23611 42407875
Basilar artery thrombosis 38.80 10.69 20 189829 231 42431255
Heart rate decreased 38.62 10.69 287 189562 36245 42395241
Thrombocytopenia 38.41 10.69 606 189243 189673 42241813
Jaundice 37.86 10.69 274 189575 34315 42397171
Neurotoxicity 37.68 10.69 30 189819 23621 42407865
Cold sweat 37.06 10.69 123 189726 11207 42420279
Burns second degree 36.90 10.69 83 189766 6013 42425473
Pathogen resistance 36.83 10.69 4 189845 11446 42420040
Cardiac septal defect 36.68 10.69 32 189817 928 42430558
Hemiparesis 36.57 10.69 164 189685 17212 42414274
Analgesic drug level above therapeutic 36.26 10.69 21 189828 310 42431176
Haemophagocytic lymphohistiocytosis 36.07 10.69 18 189831 18204 42413282
Carotid arteriosclerosis 35.86 10.69 48 189801 2284 42429202
Acute respiratory distress syndrome 35.79 10.69 49 189800 30059 42401427
Immune-mediated myositis 35.51 10.69 62 189787 3731 42427755
Gastritis erosive 35.48 10.69 85 189764 6418 42425068
Injection site pain 35.34 10.69 135 189714 57663 42373823
Cytomegalovirus viraemia 35.02 10.69 3 189846 10374 42421112
Cerebral artery thrombosis 34.94 10.69 35 189814 1214 42430272
Pulmonary vascular disorder 34.82 10.69 27 189822 661 42430825
Infusion related reaction 34.67 10.69 146 189703 60660 42370826
Device leakage 34.64 10.69 3 189846 10282 42421204
Hiatus hernia 34.56 10.69 100 189749 8460 42423026
Microangiopathy 34.50 10.69 40 189809 1642 42429844
Septic shock 34.29 10.69 253 189596 91419 42340067
Haematoma 34.21 10.69 228 189621 27795 42403691
Sinus bradycardia 34.17 10.69 144 189705 14709 42416777
Liver disorder 34.07 10.69 79 189770 39565 42391921
Accidental exposure to product 33.59 10.69 25 189824 20368 42411118
Shone complex 33.35 10.69 13 189836 72 42431414
Cytomegalovirus infection reactivation 33.30 10.69 5 189844 11173 42420313
Rales 33.14 10.69 119 189730 11281 42420205
Orthopnoea 33.06 10.69 74 189775 5343 42426143
Infective exacerbation of chronic obstructive airways disease 33.05 10.69 43 189806 1990 42429496
Akathisia 32.74 10.69 4 189845 10447 42421039
Micturition urgency 32.73 10.69 122 189727 11776 42419710
Anaemia 32.53 10.69 1543 188306 278735 42152751
Arthralgia 32.50 10.69 682 189167 204556 42226930
Blood creatinine increased 32.27 10.69 678 189171 109325 42322161
Ocular myasthenia 32.19 10.69 24 189825 553 42430933
Parosmia 32.17 10.69 91 189758 7600 42423886
Normocytic anaemia 31.59 10.69 57 189792 3520 42427966
Pancytopenia 31.39 10.69 354 189495 117389 42314097
Constipation 31.37 10.69 521 189328 161770 42269716
Haemodialysis complication 31.28 10.69 14 189835 115 42431371
Illness 31.25 10.69 39 189810 24891 42406595
Back pain 31.19 10.69 444 189405 141332 42290154
Alcohol poisoning 31.08 10.69 89 189760 7485 42424001
Bradyarrhythmia 30.80 10.69 48 189801 2627 42428859
Cytopenia 30.74 10.69 20 189829 17477 42414009
Chest pain 30.57 10.69 826 189023 138704 42292782
Diastolic dysfunction 30.56 10.69 84 189765 6899 42424587
Steroid dependence 30.56 10.69 82 189767 6640 42424846
Obstructive pancreatitis 30.54 10.69 26 189823 729 42430757
Abnormal behaviour 30.50 10.69 44 189805 26407 42405079
Eosinophilic myocarditis 30.44 10.69 34 189815 1339 42430147
Pneumonia bacterial 30.31 10.69 16 189833 15676 42415810
Depressed mood 30.22 10.69 193 189656 23191 42408295
Decreased appetite 29.93 10.69 644 189205 192493 42238993
Hypogammaglobulinaemia 29.85 10.69 8 189841 11883 42419603
Post transplant lymphoproliferative disorder 29.81 10.69 3 189846 9117 42422369
Pericardial disease 29.77 10.69 22 189827 500 42430986
Pharyngeal oedema 29.61 10.69 76 189773 5992 42425494
Chills 29.53 10.69 272 189577 93794 42337692
Cardiac murmur 29.50 10.69 124 189725 12651 42418835
Mitral valve disease 29.46 10.69 35 189814 1475 42430011
Type 2 diabetes mellitus 29.38 10.69 161 189688 18310 42413176
Wound 29.13 10.69 152 189697 16965 42414521
Transplant rejection 29.11 10.69 12 189837 13576 42417910
Post procedural haematoma 28.99 10.69 36 189813 1589 42429897
Gout 28.86 10.69 219 189630 27836 42403650
Erysipelas 28.82 10.69 77 189772 6219 42425267
Euglycaemic diabetic ketoacidosis 28.77 10.69 72 189777 5588 42425898
Cardiovascular insufficiency 28.72 10.69 38 189811 1788 42429698
Pemphigoid 28.61 10.69 114 189735 11353 42420133
Cerebrovascular accident 28.55 10.69 599 189250 96561 42334925
Gingival pain 28.48 10.69 93 189756 8401 42423085
Infection 28.30 10.69 341 189508 111727 42319759
Blood creatine phosphokinase increased 27.99 10.69 334 189515 48004 42383482
Chronotropic incompetence 27.91 10.69 9 189840 25 42431461
Seizure 27.78 10.69 374 189475 120187 42311299
Blood bilirubin abnormal 27.78 10.69 26 189823 828 42430658
Multiple organ dysfunction syndrome 27.76 10.69 287 189562 96748 42334738
Mucosal haemorrhage 27.76 10.69 37 189812 1753 42429733
Insomnia 27.56 10.69 366 189483 117887 42313599
Epstein-Barr virus infection 27.50 10.69 5 189844 9713 42421773
Blood pressure systolic increased 27.48 10.69 216 189633 27752 42403734
Diabetic foetopathy 27.29 10.69 15 189834 199 42431287
Product storage error 27.03 10.69 8 189841 11132 42420354
Polyuria 27.00 10.69 102 189747 9909 42421577
Nasal congestion 26.81 10.69 57 189792 29444 42402042
Helicobacter test positive 26.64 10.69 25 189824 799 42430687
Ventricular tachycardia 26.44 10.69 227 189622 29933 42401553
Malnutrition 26.41 10.69 16 189833 14526 42416960
Pneumonia aspiration 26.28 10.69 124 189725 49954 42381532
Nicotine dependence 26.28 10.69 23 189826 670 42430816
Nephrotic syndrome 26.19 10.69 92 189757 8626 42422860
Hypopnoea 26.16 10.69 86 189763 7796 42423690
Therapeutic response unexpected 26.14 10.69 9 189840 11372 42420114
Pneumocystis jirovecii pneumonia 26.08 10.69 45 189804 25136 42406350
Cerebral haematoma 26.08 10.69 69 189780 5541 42425945
Lymphocyte count decreased 25.89 10.69 53 189796 27756 42403730
Chronic obstructive pulmonary disease 25.88 10.69 410 189439 62704 42368782
Nephroangiosclerosis 25.72 10.69 14 189835 182 42431304
Actinic elastosis 25.71 10.69 10 189839 55 42431431
Vertebral osteophyte 25.71 10.69 10 189839 55 42431431
Therapy cessation 25.62 10.69 32 189817 20418 42411068
N-terminal prohormone brain natriuretic peptide increased 25.52 10.69 51 189798 3402 42428084
Embolic stroke 25.50 10.69 64 189785 4976 42426510
Physical examination abnormal 25.33 10.69 19 189830 442 42431044
Patent ductus arteriosus 25.28 10.69 51 189798 3425 42428061
Sedation 25.17 10.69 62 189787 30413 42401073
Aspartate aminotransferase increased 25.15 10.69 221 189628 76942 42354544
Gamma-glutamyltransferase increased 25.12 10.69 238 189611 32259 42399227
Blood pressure systolic decreased 24.89 10.69 63 189786 4924 42426562
Epistaxis 24.78 10.69 427 189422 66399 42365087
Ventricular dysfunction 24.72 10.69 59 189790 4444 42427042
Haematotoxicity 24.70 10.69 9 189840 10976 42420510
Nasopharyngitis 24.62 10.69 247 189602 83749 42347737
Pulmonary valve disease 24.59 10.69 18 189831 403 42431083
Ventricular enlargement 24.57 10.69 22 189827 661 42430825
Incorrect dose administered 24.50 10.69 137 189712 52837 42378649
Immune effector cell-associated neurotoxicity syndrome 24.45 10.69 6 189843 9455 42422031
Anuria 24.38 10.69 109 189740 11423 42420063
Foetal exposure during pregnancy 24.33 10.69 118 189731 47193 42384293
Systemic lupus erythematosus 24.32 10.69 94 189755 9230 42422256
Tachyarrhythmia 24.32 10.69 54 189795 3878 42427608
Product dose omission in error 24.29 10.69 4 189845 8350 42423136
Respiratory arrest 24.13 10.69 57 189792 28367 42403119
Echocardiogram abnormal 24.06 10.69 29 189820 1241 42430245
Myositis 23.92 10.69 130 189719 14736 42416750
Cardiac aneurysm 23.92 10.69 27 189822 1076 42430410
Gravitational oedema 23.89 10.69 22 189827 686 42430800
Mouth breathing 23.81 10.69 11 189838 98 42431388
Malignant spinal cord compression 23.71 10.69 12 189837 133 42431353
Encephalopathy 23.71 10.69 99 189750 41234 42390252
Phalangeal hypoplasia 23.70 10.69 10 189839 70 42431416
Intentional product misuse 23.54 10.69 170 189679 61730 42369756
Hypertrophy 23.53 10.69 19 189830 494 42430992
Camptocormia 23.49 10.69 13 189836 175 42431311
Mucosal dryness 23.48 10.69 33 189816 1645 42429841
Hypoalbuminaemia 23.40 10.69 21 189828 15589 42415897
Anaemia macrocytic 23.33 10.69 50 189799 3505 42427981
Aorta hypoplasia 23.25 10.69 11 189838 104 42431382
Melanoderma 23.17 10.69 13 189836 180 42431306
Anal haemorrhage 23.14 10.69 44 189805 2829 42428657
Cardiac discomfort 23.14 10.69 22 189827 715 42430771
Cardiac septal hypertrophy 23.09 10.69 17 189832 384 42431102
Renal injury 23.02 10.69 13 189836 12267 42419219
Gingival hypertrophy 23.00 10.69 40 189809 2399 42429087
Atrioventricular block complete 22.97 10.69 106 189743 11258 42420228
Exposure during pregnancy 22.93 10.69 5 189844 8543 42422943
Cranial sutures widening 22.80 10.69 11 189838 109 42431377
Glomerular filtration rate 22.80 10.69 11 189838 109 42431377
Tumour lysis syndrome 22.77 10.69 40 189809 22191 42409295
Atrioventricular block 22.73 10.69 94 189755 9521 42421965
Hypersomnia 22.72 10.69 19 189830 14599 42416887
Foetal disorder 22.70 10.69 26 189823 1053 42430433
Cough 22.68 10.69 990 188859 177113 42254373
Chronic sinusitis 22.60 10.69 48 189801 3344 42428142
Duodenitis 22.52 10.69 65 189784 5491 42425995
Dermatitis allergic 22.52 10.69 86 189763 8397 42423089
Tubulointerstitial nephritis 22.41 10.69 227 189622 31321 42400165
Drug use disorder 22.34 10.69 9 189840 10324 42421162
Fluid intake reduced 22.32 10.69 53 189796 3979 42427507
Haematemesis 22.27 10.69 219 189630 29980 42401506
Sudden cardiac death 22.18 10.69 52 189797 3872 42427614
Left atrial dilatation 22.14 10.69 39 189810 2363 42429123
Macrophages increased 22.11 10.69 12 189837 155 42431331
Vasculitic rash 22.06 10.69 25 189824 1001 42430485
Therapy non-responder 22.05 10.69 143 189706 53216 42378270
Dystonia 21.96 10.69 15 189834 12775 42418711
Stenosis 21.86 10.69 36 189813 2065 42429421
Hypercreatinaemia 21.81 10.69 14 189835 251 42431235
Nightmare 21.79 10.69 188 189661 24824 42406662
Renal impairment 21.75 10.69 644 189205 109584 42321902
Mitral valve hypoplasia 21.69 10.69 8 189841 37 42431449
Heart rate irregular 21.69 10.69 134 189715 15916 42415570
Immune reconstitution inflammatory syndrome 21.66 10.69 9 189840 10134 42421352
Alopecia 21.58 10.69 63 189786 29213 42402273
Diarrhoea 21.56 10.69 1764 188085 459085 41972401
Thrombosis 21.55 10.69 198 189651 68313 42363173
Blood potassium increased 21.54 10.69 149 189700 18387 42413099
Myelodysplastic syndrome 21.47 10.69 43 189806 22702 42408784
Anhedonia 21.47 10.69 4 189845 7636 42423850
Low cardiac output syndrome 21.44 10.69 20 189829 634 42430852
Mouth swelling 21.40 10.69 37 189812 2209 42429277
Loss of proprioception 21.28 10.69 17 189832 435 42431051
Blood creatine phosphokinase abnormal 21.26 10.69 16 189833 374 42431112
Accidental overdose 21.16 10.69 206 189643 28124 42403362
Diabetic ketoacidosis 21.02 10.69 171 189678 22196 42409290
Injection site erythema 20.99 10.69 36 189813 20159 42411327
Face oedema 20.99 10.69 118 189731 13548 42417938
Chronic kidney disease 20.95 10.69 311 189538 46930 42384556
Supravalvular aortic stenosis 20.87 10.69 8 189841 42 42431444
Deep vein thrombosis 20.65 10.69 231 189618 76726 42354760
Surgery 20.61 10.69 29 189820 17587 42413899
Agitation 20.60 10.69 185 189664 64129 42367357
Poisoning 20.60 10.69 21 189828 14678 42416808
Low density lipoprotein abnormal 20.52 10.69 16 189833 395 42431091
Fracture displacement 20.45 10.69 13 189836 229 42431257
Precancerous skin lesion 20.41 10.69 19 189830 601 42430885
Laboratory test abnormal 20.38 10.69 45 189804 22933 42408553
Injection site reaction 20.33 10.69 24 189825 15697 42415789
Pharyngeal necrosis 20.31 10.69 9 189840 72 42431414
Neoplasm progression 20.24 10.69 64 189785 28936 42402550
Multiple-drug resistance 20.22 10.69 4 189845 7318 42424168
Laryngeal cleft 19.97 10.69 6 189843 12 42431474
Body temperature decreased 19.90 10.69 121 189728 14292 42417194
Carcinogenicity 19.90 10.69 9 189840 76 42431410
Trigger finger 19.89 10.69 24 189825 1028 42430458
Pseudomonas infection 19.86 10.69 25 189824 15898 42415588
Lichenoid keratosis 19.82 10.69 50 189799 3900 42427586
Band neutrophil percentage decreased 19.65 10.69 6 189843 13 42431473
Anastomotic infection 19.51 10.69 10 189839 114 42431372
Oedema mouth 19.44 10.69 27 189822 1331 42430155
Post-traumatic amnestic disorder 19.33 10.69 8 189841 53 42431433
Red blood cell abnormality 19.30 10.69 16 189833 432 42431054
Duodenal ulcer perforation 19.25 10.69 31 189818 1745 42429741
Dysarthria 19.22 10.69 266 189583 39541 42391945
Behaviour disorder 19.18 10.69 4 189845 7050 42424436
Atrial septal defect 19.18 10.69 78 189771 7841 42423645
Pancreatitis necrotising 19.16 10.69 47 189802 3602 42427884
Intentional dose omission 19.15 10.69 8 189841 8978 42422508
Arterial spasm 19.12 10.69 9 189840 84 42431402
Pharyngeal swelling 19.09 10.69 45 189804 3362 42428124
Vascular access site occlusion 19.08 10.69 8 189841 55 42431431
Neutropenia neonatal 19.07 10.69 22 189827 898 42430588
Mucosal inflammation 19.06 10.69 135 189714 49239 42382247
Angina unstable 19.03 10.69 101 189748 11347 42420139
Xyphoid retraction 19.01 10.69 11 189838 162 42431324
Genital herpes simplex 19.00 10.69 10 189839 121 42431365
Colitis ulcerative 18.91 10.69 189 189660 25986 42405500
Joint injury 18.88 10.69 121 189728 14555 42416931
Hypomagnesaemia 18.82 10.69 202 189647 28286 42403200
Acute respiratory failure 18.79 10.69 99 189750 38759 42392727
Rhinitis 18.78 10.69 104 189745 11873 42419613
Peritonitis 18.66 10.69 34 189815 18599 42412887
Influenza 18.56 10.69 182 189667 61993 42369493
C-reactive protein abnormal 18.55 10.69 9 189840 9252 42422234
Upper respiratory tract infection 18.47 10.69 111 189738 42062 42389424
BK virus infection 18.43 10.69 8 189841 8776 42422710
Hypovolaemic shock 18.42 10.69 82 189767 8577 42422909
Tendon rupture 18.31 10.69 78 189771 8005 42423481
Nephrolithiasis 18.28 10.69 93 189756 36737 42394749
Cystitis haemorrhagic 18.27 10.69 5 189844 7324 42424162
Lordosis 18.25 10.69 14 189835 337 42431149
Upper motor neurone lesion 18.22 10.69 11 189838 176 42431310
Hyperglycaemia 18.08 10.69 296 189553 45563 42385923
Helicobacter test false negative 18.05 10.69 8 189841 64 42431422
Obsessive-compulsive disorder 17.97 10.69 4 189845 6739 42424747
Polycystic liver disease 17.92 10.69 9 189840 98 42431388
Haematocrit increased 17.89 10.69 37 189812 2530 42428956
Epiglottic oedema 17.74 10.69 11 189838 185 42431301
Palmar-plantar erythrodysaesthesia syndrome 17.69 10.69 41 189808 20541 42410945
Hereditary haemorrhagic telangiectasia 17.63 10.69 7 189842 41 42431445
Intentional product use issue 17.58 10.69 220 189629 71613 42359873
Arthropathy 17.53 10.69 70 189779 29527 42401959
Left ventricular enlargement 17.42 10.69 20 189829 812 42430674
Ketoacidosis 17.41 10.69 58 189791 5294 42426192
Spinal pain 17.39 10.69 68 189781 6714 42424772
Eye injury 17.35 10.69 22 189827 992 42430494
Arteriosclerotic gangrene 17.34 10.69 8 189841 71 42431415
Resuscitation 17.30 10.69 30 189819 1795 42429691
Fungal infection 17.19 10.69 39 189810 19683 42411803
Pneumothorax 17.11 10.69 51 189798 23492 42407994
Product administration error 17.11 10.69 140 189709 18203 42413283
Atelectasis 17.10 10.69 38 189811 19323 42412163
Dermatitis exfoliative generalised 17.10 10.69 61 189788 5763 42425723
Enterococcal infection 17.10 10.69 17 189832 12022 42419464
Feeling abnormal 16.98 10.69 214 189635 69572 42361914
Anorgasmia 16.87 10.69 23 189826 1114 42430372
Nausea 16.87 10.69 1530 188319 395269 42036217
Paraesthesia oral 16.84 10.69 56 189793 5107 42426379
Osteomyelitis 16.73 10.69 35 189814 18188 42413298
Left ventricular hypertrophy 16.73 10.69 84 189765 9235 42422251
Neuroleptic malignant syndrome 16.72 10.69 45 189804 21427 42410059
Type V hyperlipidaemia 16.70 10.69 21 189828 939 42430547
Renal-limited thrombotic microangiopathy 16.65 10.69 12 189837 262 42431224
Hepatitis cholestatic 16.55 10.69 87 189762 9737 42421749
Nasal polyps 16.53 10.69 46 189803 3805 42427681
Hypoaesthesia eye 16.40 10.69 6 189843 27 42431459
Body temperature increased 16.36 10.69 42 189807 20316 42411170
Immunodeficiency 16.34 10.69 6 189843 7284 42424202
Altered state of consciousness 16.21 10.69 71 189778 29188 42402298
Clostridium difficile colitis 16.21 10.69 45 189804 21207 42410279
Cardiac ventricular disorder 16.15 10.69 12 189837 275 42431211
Contraindicated product administered 16.14 10.69 178 189671 25094 42406392
Syringe issue 16.12 10.69 9 189840 8547 42422939
Idiopathic angioedema 16.03 10.69 5 189844 12 42431474
Oral neoplasm 15.95 10.69 9 189840 126 42431360
Carcinoma in situ of skin 15.94 10.69 8 189841 87 42431399
Enlarged uvula 15.93 10.69 12 189837 281 42431205
Congenital heart valve disorder 15.91 10.69 7 189842 55 42431431
Suspected suicide 15.89 10.69 4 189845 6195 42425291
Osteonecrosis 15.84 10.69 29 189820 15836 42415650
Abnormal weight gain 15.78 10.69 24 189825 1286 42430200
Tendon pain 15.76 10.69 41 189808 3259 42428227
Granulocytopenia 15.71 10.69 6 189843 7108 42424378
Withdrawal syndrome 15.67 10.69 26 189823 14749 42416737
Herpes zoster 15.65 10.69 105 189744 38772 42392714
Polyomavirus-associated nephropathy 15.65 10.69 3 189846 5612 42425874
Accessory spleen 15.65 10.69 9 189840 131 42431355
Atrial thrombosis 15.61 10.69 34 189815 2410 42429076
Delusion 15.56 10.69 26 189823 14708 42416778
Splenic cyst 15.53 10.69 9 189840 133 42431353
Neurological symptom 15.51 10.69 13 189836 9978 42421508
Internal fixation of fracture 15.48 10.69 8 189841 93 42431393
Miller Fisher syndrome 15.47 10.69 9 189840 134 42431352
Liver function test abnormal 15.46 10.69 216 189633 32175 42399311
Loss of control of legs 15.45 10.69 19 189830 830 42430656
Derailment 15.45 10.69 4 189845 3 42431483
Peripheral pulse decreased 15.45 10.69 4 189845 3 42431483
Pain 15.41 10.69 913 188936 243935 42187551
Osteoma 15.40 10.69 8 189841 94 42431392
Rhinovirus infection 15.35 10.69 5 189844 6543 42424943
Prohormone brain natriuretic peptide increased 15.26 10.69 8 189841 96 42431390
Antidepressant drug level below therapeutic 15.23 10.69 5 189844 15 42431471
Hyperammonaemia 15.22 10.69 8 189841 7858 42423628
Cheyne-Stokes respiration 15.19 10.69 12 189837 302 42431184
Intrapericardial thrombosis 15.19 10.69 7 189842 62 42431424
Strangury 15.18 10.69 9 189840 139 42431347
Pulmonary congestion 15.18 10.69 121 189728 15609 42415877
Pulmonary haemorrhage 15.17 10.69 17 189832 11380 42420106
Cardiogenic shock 15.17 10.69 233 189616 35407 42396079
Oesophageal discomfort 15.11 10.69 8 189841 98 42431388
Haemoglobin urine present 15.07 10.69 9 189840 141 42431345
Device issue 15.06 10.69 23 189826 13486 42418000
Rebound effect 15.04 10.69 7 189842 7372 42424114
Treatment noncompliance 15.04 10.69 102 189747 37570 42393916
Pulse abnormal 14.99 10.69 24 189825 1344 42430142
Eczema nummular 14.85 10.69 10 189839 195 42431291
Muscle enzyme increased 14.83 10.69 12 189837 313 42431173
Rhinorrhoea 14.82 10.69 82 189767 31712 42399774
Interstitial lung disease 14.78 10.69 253 189596 78209 42353277
Vocal cord inflammation 14.72 10.69 7 189842 67 42431419
Activated partial thromboplastin time abnormal 14.69 10.69 9 189840 148 42431338
Oliguria 14.69 10.69 81 189768 9232 42422254
Eosinophil count decreased 14.65 10.69 42 189807 3534 42427952
Diabetes mellitus inadequate control 14.64 10.69 118 189731 15272 42416214
Base excess decreased 14.63 10.69 10 189839 200 42431286
Gastrointestinal disorder 14.59 10.69 135 189714 46518 42384968
Thyroiditis acute 14.57 10.69 8 189841 106 42431380
Obesity 14.49 10.69 124 189725 16335 42415151
Perineal pain 14.48 10.69 20 189829 981 42430505
Venous pressure jugular decreased 14.47 10.69 6 189843 40 42431446
Prostatic haemorrhage 14.41 10.69 11 189838 263 42431223
5-hydroxyindolacetic acid increased 14.37 10.69 8 189841 109 42431377
Blood immunoglobulin E increased 14.30 10.69 42 189807 3583 42427903
Ocular icterus 14.27 10.69 38 189811 3063 42428423
Jealous delusion 14.26 10.69 13 189836 400 42431086
Acute myeloid leukaemia 14.24 10.69 51 189798 22205 42409281
Akinesia 14.23 10.69 33 189816 2439 42429047
Thirst 14.22 10.69 79 189770 9029 42422457
Hypersensitivity vasculitis 14.17 10.69 39 189810 3205 42428281
Posterior reversible encephalopathy syndrome 14.13 10.69 22 189827 12799 42418687
Venoocclusive liver disease 14.12 10.69 15 189834 10287 42421199
Blood lactic acid increased 14.10 10.69 72 189777 7967 42423519
Ascites 14.09 10.69 173 189676 56505 42374981
Large for dates baby 14.08 10.69 19 189830 911 42430575
Bacterial infection 14.06 10.69 70 189779 27809 42403677
Pulmonary thrombosis 14.05 10.69 10 189839 8338 42423148
Nocardiosis 13.99 10.69 3 189846 5187 42426299
Facial bones fracture 13.99 10.69 32 189817 2344 42429142
Dermatitis atopic 13.94 10.69 21 189828 12383 42419103
Gastritis haemorrhagic 13.93 10.69 26 189823 1648 42429838
Duodenal ulcer haemorrhage 13.90 10.69 57 189792 5751 42425735
Dysuria 13.90 10.69 205 189644 30891 42400595
Bursitis infective 13.89 10.69 16 189833 652 42430834
Emotional distress 13.88 10.69 32 189817 16061 42415425
Splenic necrosis 13.88 10.69 8 189841 117 42431369
Cellulitis 13.83 10.69 192 189657 61393 42370093
Subclavian artery occlusion 13.82 10.69 8 189841 118 42431368
Sinus arrest 13.78 10.69 30 189819 2126 42429360
Urinary hesitation 13.77 10.69 37 189812 2998 42428488
Microcytic anaemia 13.77 10.69 37 189812 2998 42428488
Flagellate dermatitis 13.76 10.69 8 189841 119 42431367
Underdose 13.69 10.69 34 189815 16632 42414854
Mean cell haemoglobin concentration 13.65 10.69 6 189843 47 42431439
Blood pressure decreased 13.53 10.69 348 189501 57984 42373502
Left ventricular failure 13.51 10.69 58 189791 5973 42425513
Chronic coronary syndrome 13.49 10.69 11 189838 290 42431196
Muscular weakness 13.40 10.69 476 189373 83022 42348464
N-terminal prohormone brain natriuretic peptide abnormal 13.39 10.69 10 189839 231 42431255
Hypertension 13.37 10.69 890 188959 166314 42265172
Abdominal pain lower 13.35 10.69 96 189753 11996 42419490
Increased appetite 13.32 10.69 12 189837 8894 42422592
Alanine aminotransferase increased 13.32 10.69 296 189553 88110 42343376
Gingival hypoplasia 13.32 10.69 4 189845 8 42431478
Ischaemia 13.26 10.69 51 189798 4996 42426490
Breast hyperplasia 13.26 10.69 3 189846 0 42431486
Blood product transfusion dependent 13.24 10.69 13 189836 440 42431046
Type 1 diabetes mellitus 13.20 10.69 4 189845 5483 42426003
Intervertebral disc displacement 13.20 10.69 8 189841 129 42431357
Oxygen consumption decreased 13.18 10.69 11 189838 300 42431186
Clostridium difficile infection 13.16 10.69 54 189795 22605 42408881
Ear infection 13.15 10.69 23 189826 12781 42418705
Aortic stenosis 13.09 10.69 75 189774 8670 42422816
Blood pressure inadequately controlled 13.05 10.69 35 189814 2833 42428653
Hypoglycaemic coma 13.01 10.69 34 189815 2710 42428776
Urostomy complication 13.00 10.69 4 189845 9 42431477
Paresis 12.95 10.69 32 189817 2464 42429022
Product prescribing issue 12.94 10.69 7 189842 6766 42424720
Pneumonia pseudomonal 12.91 10.69 3 189846 4906 42426580
Mydriasis 12.90 10.69 12 189837 8758 42422728
Allergy to animal 12.85 10.69 14 189835 536 42430950
Blood ethanol increased 12.83 10.69 13 189836 457 42431029
Basal ganglia stroke 12.79 10.69 7 189842 92 42431394
Ventricular internal diameter abnormal 12.79 10.69 9 189840 189 42431297
Acne 12.70 10.69 26 189823 13618 42417868
Eczema 12.70 10.69 218 189631 33868 42397618
Impaired self-care 12.61 10.69 21 189828 1216 42430270
Hypovolaemia 12.57 10.69 91 189758 11394 42420092
Arterial intramural haematoma 12.57 10.69 6 189843 58 42431428
Fatigue 12.56 10.69 1725 188124 433916 41997570
Pulmonary toxicity 12.55 10.69 12 189837 8643 42422843
Radiation necrosis 12.52 10.69 10 189839 256 42431230
Megakaryocytes increased 12.50 10.69 5 189844 30 42431456
Autoimmune colitis 12.48 10.69 20 189829 1121 42430365
Hypersensitivity 12.48 10.69 237 189612 72133 42359353
Plasma cell myeloma recurrent 12.47 10.69 5 189844 5752 42425734
Tuberculosis 12.45 10.69 16 189833 10083 42421403
Device pacing issue 12.30 10.69 6 189843 61 42431425
Intracranial haematoma 12.22 10.69 14 189835 567 42430919
Epiglottitis 12.22 10.69 12 189837 406 42431080
Impaired work ability 12.22 10.69 94 189755 11997 42419489
Ejection fraction 12.20 10.69 9 189840 204 42431282
Hyperlactacidaemia 12.17 10.69 46 189803 4470 42427016
Cerebral calcification 12.17 10.69 7 189842 102 42431384
Pyelitis 12.15 10.69 8 189841 150 42431336
Overflow diarrhoea 12.14 10.69 6 189843 63 42431423
Faeces pale 12.12 10.69 24 189825 1590 42429896
Implant site inflammation 12.11 10.69 7 189842 103 42431383
Hepatic cyst 12.08 10.69 35 189814 2963 42428523
Basal ganglia haemorrhage 12.07 10.69 19 189830 1049 42430437
Bleeding time prolonged 12.06 10.69 15 189834 663 42430823
Venous pressure jugular increased 12.04 10.69 16 189833 756 42430730
Enterocolitis 11.96 10.69 16 189833 9913 42421573
Ammonia increased 11.95 10.69 3 189846 4656 42426830
Fibrinolysis increased 11.94 10.69 4 189845 13 42431473
Sex hormone binding globulin increased 11.94 10.69 4 189845 13 42431473
Blood osmolarity increased 11.94 10.69 12 189837 418 42431068
Lymphoma 11.93 10.69 29 189820 14292 42417194
Macroglossia 11.91 10.69 13 189836 499 42430987
Respiratory tract haemorrhage 11.87 10.69 22 189827 1387 42430099
Infected skin ulcer 11.87 10.69 27 189822 1971 42429515
Nephropathy toxic 11.86 10.69 37 189812 16801 42414685
Irritability 11.81 10.69 75 189774 28053 42403433
Blood follicle stimulating hormone increased 11.79 10.69 9 189840 215 42431271
Intermittent claudication 11.76 10.69 31 189818 2484 42429002
Device difficult to use 11.71 10.69 3 189846 4593 42426893
Adrenal insufficiency 11.69 10.69 44 189805 18880 42412606
Diffuse large B-cell lymphoma 11.63 10.69 15 189834 9439 42422047
Device dislocation 11.62 10.69 67 189782 7764 42423722
Genitourinary symptom 11.62 10.69 5 189844 37 42431449
Drug eruption 11.60 10.69 58 189791 23017 42408469
Glomerular filtration rate abnormal 11.50 10.69 20 189829 1200 42430286
Monoparesis 11.39 10.69 34 189815 2926 42428560
Right ventricular enlargement 11.36 10.69 13 189836 526 42430960
Muscle rupture 11.33 10.69 30 189819 2410 42429076
Bronchial carcinoma 11.32 10.69 18 189831 1002 42430484
Glomerulonephritis membranous 11.32 10.69 22 189827 1438 42430048
Atrioventricular block first degree 11.29 10.69 58 189791 6433 42425053
Electrocardiogram QRS complex shortened 11.28 10.69 9 189840 230 42431256
Pneumonitis 11.27 10.69 125 189724 41593 42389893
Osteopenia 11.27 10.69 7 189842 6271 42425215
Neutropenic colitis 11.23 10.69 3 189846 4467 42427019
Blood lactate dehydrogenase increased 11.23 10.69 69 189780 26012 42405474
Drug-disease interaction 11.20 10.69 17 189832 909 42430577
Implant site extravasation 11.20 10.69 12 189837 451 42431035
Supine hypertension 11.16 10.69 11 189838 374 42431112
Thalamic infarction 11.15 10.69 16 189833 813 42430673
Total lung capacity abnormal 11.13 10.69 3 189846 4440 42427046
Meningorrhagia 11.13 10.69 7 189842 121 42431365
Unresponsive to stimuli 11.10 10.69 88 189761 31315 42400171
Congenital aortic anomaly 11.09 10.69 6 189843 77 42431409
Coronary arterial stent insertion 11.08 10.69 41 189808 3944 42427542
Tongue dry 11.04 10.69 10 189839 305 42431181
Compartment syndrome 11.02 10.69 36 189813 3253 42428233
Leukaemia 10.98 10.69 6 189843 5766 42425720
Acute stress disorder 10.97 10.69 8 189841 178 42431308
Ataxia 10.96 10.69 36 189813 16089 42415397
Diabetic metabolic decompensation 10.96 10.69 27 189822 2075 42429411
Coarctation of the aorta 10.94 10.69 12 189837 463 42431023
Articular disc disorder 10.94 10.69 4 189845 18 42431468
Anaemia vitamin B12 deficiency 10.90 10.69 13 189836 550 42430936
Dyspnoea paroxysmal nocturnal 10.88 10.69 23 189826 1597 42429889
Balanoposthitis 10.87 10.69 23 189826 1598 42429888
Mitral valve thickening 10.84 10.69 12 189837 468 42431018
Iron deficiency anaemia 10.83 10.69 97 189752 12942 42418544
Metastases to bone 10.82 10.69 32 189817 14777 42416709
Lower respiratory tract infection 10.81 10.69 250 189599 40956 42390530
Oxygen saturation decreased 10.80 10.69 213 189636 64474 42367012
Angiopathy 10.75 10.69 50 189799 5327 42426159
Blood cholinesterase decreased 10.74 10.69 8 189841 184 42431302
Seasonal allergy 10.74 10.69 12 189837 8043 42423443

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1201.85 10.10 5804 487060 629626 109466809
General physical health deterioration 894.13 10.10 4009 488855 421286 109675149
Hyperkalaemia 878.30 10.10 1898 490966 133898 109962537
Drug ineffective 771.81 10.10 3827 489037 1516713 108579722
Death 734.34 10.10 1242 491622 697627 109398808
Completed suicide 673.76 10.10 131 492733 242250 109854185
Product dose omission issue 600.19 10.10 344 492520 321438 109774997
Angioedema 563.10 10.10 1311 491553 97189 109999246
Off label use 541.00 10.10 4197 488667 1495988 108600447
Hyponatraemia 446.96 10.10 2039 490825 215614 109880821
Product prescribing error 438.17 10.10 806 492058 50525 110045910
Hypertensive crisis 428.42 10.10 536 492328 23836 110072599
Febrile neutropenia 412.64 10.10 482 492382 316285 109780150
Syncope 397.83 10.10 1873 490991 200663 109895772
Bradycardia 394.58 10.10 1554 491310 153963 109942472
Toxicity to various agents 354.56 10.10 1036 491828 479519 109616916
Disease progression 353.98 10.10 339 492525 243695 109852740
Liver injury 353.70 10.10 1468 491396 148945 109947490
White blood cell count decreased 332.31 10.10 319 492545 229071 109867364
Confusional state 325.74 10.10 3356 489508 465324 109631111
Neutropenia 318.64 10.10 752 492112 373868 109722567
Drug interaction 305.71 10.10 3491 489373 496692 109599743
Angina pectoris 303.63 10.10 780 492084 61515 110034920
Platelet count decreased 299.64 10.10 351 492513 230092 109866343
Lactic acidosis 260.53 10.10 958 491906 91853 110004582
Hypotension 257.28 10.10 3510 489354 520339 109576096
Swollen tongue 256.08 10.10 718 492146 59644 110036791
Hypercholesterolaemia 249.44 10.10 931 491933 89906 110006529
Drug ineffective for unapproved indication 244.12 10.10 77 492787 102761 109993674
Product monitoring error 242.00 10.10 246 492618 8681 110087754
Injection site pain 239.98 10.10 263 492601 177659 109918776
Lip swelling 239.30 10.10 627 492237 50040 110046395
Peripheral venous disease 235.04 10.10 867 491997 83250 110013185
Type 2 diabetes mellitus 234.68 10.10 1472 491392 175760 109920675
Cardiac failure 228.64 10.10 1526 491338 186100 109910335
Neuropathy peripheral 223.57 10.10 282 492582 178995 109917440
Presyncope 219.78 10.10 594 492270 48293 110048142
Injection site erythema 202.31 10.10 83 492781 94093 110002342
Dizziness 201.38 10.10 4292 488572 693901 109402534
Psoriatic arthropathy 195.08 10.10 1523 491341 195238 109901197
Neutrophil count decreased 193.48 10.10 153 492711 120788 109975647
Musculoskeletal pain 188.31 10.10 1429 491435 181594 109914841
Rheumatic fever 185.89 10.10 1055 491809 121524 109974911
Tongue oedema 183.94 10.10 205 492659 8051 110088384
Sopor 180.56 10.10 460 492404 36086 110060349
Pyrexia 172.83 10.10 2890 489974 895375 109201060
Back pain 169.28 10.10 965 491899 370031 109726404
Breast cancer stage III 168.81 10.10 750 492114 78367 110018068
Myelosuppression 165.75 10.10 108 492756 94232 110002203
Melaena 160.70 10.10 670 492194 68087 110028348
Lip dry 160.14 10.10 874 491990 99209 109997226
Labelled drug-drug interaction medication error 159.75 10.10 383 492481 28919 110067516
Wrong technique in product usage process 158.98 10.10 96 492768 87252 110009183
Obesity 158.53 10.10 955 491909 112396 109984039
Wound infection 152.73 10.10 840 492024 95625 110000810
Mental status changes 152.65 10.10 74 492790 76048 110020387
Cytokine release syndrome 152.58 10.10 61 492803 70245 110026190
Atrial fibrillation 152.43 10.10 1630 491234 228012 109868423
Blood cholesterol increased 151.63 10.10 1371 491493 183414 109913021
Orthostatic hypotension 151.28 10.10 641 492223 65608 110030827
Malignant neoplasm progression 150.21 10.10 348 492516 174219 109922216
Hypoglycaemia 149.72 10.10 958 491906 115146 109981289
Respiratory failure 148.05 10.10 479 492385 214853 109881582
Wound 146.85 10.10 1645 491219 232792 109863643
Pulmonary fibrosis 142.88 10.10 860 492004 101182 109995253
Hepatic function abnormal 141.53 10.10 114 492750 89181 110007254
COVID-19 139.72 10.10 589 492275 244471 109851964
Pemphigus 138.22 10.10 1514 491350 213056 109883379
Sepsis 135.40 10.10 878 491986 326468 109769967
Hypoxia 132.96 10.10 233 492631 129282 109967153
Circulatory collapse 126.74 10.10 451 492413 42542 110053893
Joint range of motion decreased 126.26 10.10 953 491911 120879 109975556
Therapy interrupted 126.17 10.10 33 492831 49789 110046646
Acute myocardial infarction 125.65 10.10 719 492145 83058 110013377
Cytomegalovirus infection 125.28 10.10 43 492821 54401 110042034
Ischaemic stroke 125.21 10.10 437 492427 40826 110055609
Pneumonia 121.09 10.10 2979 489885 873735 109222700
Duodenal ulcer perforation 120.55 10.10 1267 491597 176433 109920002
Injection site pruritus 120.54 10.10 39 492825 51219 110045216
Bursitis 120.21 10.10 990 491874 128928 109967507
Constipation 120.06 10.10 1018 491846 356768 109739667
Device expulsion 119.54 10.10 4 492860 30887 110065548
Cardio-respiratory arrest 119.26 10.10 208 492656 115628 109980807
Electrolyte imbalance 119.23 10.10 400 492464 36628 110059807
Systemic infection 118.34 10.10 180 492684 9639 110086796
Night sweats 118.14 10.10 1010 491854 132973 109963462
Pericarditis 117.64 10.10 1493 491371 217621 109878814
Fall 116.09 10.10 3515 489349 599967 109496468
Deep vein thrombosis postoperative 116.04 10.10 548 492316 58743 110037692
Facet joint syndrome 114.56 10.10 782 492082 96046 110000389
Upper respiratory tract infection 112.01 10.10 263 492601 131065 109965370
Fibromyalgia 111.00 10.10 1208 491656 169701 109926734
Chills 108.03 10.10 459 492405 190121 109906314
Mobility decreased 107.09 10.10 1568 491296 235854 109860581
Unevaluable event 105.13 10.10 67 492797 59160 110037275
Haematochezia 105.10 10.10 877 491987 114647 109981788
Dehydration 104.91 10.10 1790 491074 277721 109818714
Drug abuse 104.47 10.10 421 492443 176990 109919445
Nasal congestion 104.38 10.10 173 492691 98109 109998326
Hospitalisation 104.29 10.10 308 492556 142185 109954250
Rhabdomyolysis 104.25 10.10 904 491960 119497 109976938
Muscle injury 102.68 10.10 1019 491845 139788 109956647
Arrhythmia 101.65 10.10 593 492271 68982 110027453
Abdominal pain upper 101.60 10.10 2150 490714 346961 109749474
Rectal haemorrhage 101.29 10.10 895 491969 118938 109977497
Drug resistance 101.13 10.10 63 492801 56311 110040124
Blepharospasm 100.88 10.10 498 492366 54353 110042082
Autoimmune disorder 100.17 10.10 565 492299 64918 110031517
Accidental exposure to product 99.68 10.10 49 492815 49959 110046476
Ejection fraction decreased 99.18 10.10 403 492461 40477 110055958
Medication error 99.13 10.10 806 492058 104560 109991875
Swollen joint count increased 98.58 10.10 675 492189 82986 110013449
Respiratory arrest 96.75 10.10 71 492793 58228 110038207
Seizure 96.72 10.10 583 492281 220602 109875833
Gangrene 96.07 10.10 220 492644 16121 110080314
Hemiparesis 95.77 10.10 419 492445 43484 110052951
Congenital hiatus hernia 94.93 10.10 128 492736 6131 110090304
Arterial occlusive disease 94.35 10.10 210 492654 15098 110081337
Lower respiratory tract infection 93.46 10.10 1563 491301 241543 109854892
Lupus vulgaris 92.75 10.10 347 492517 33536 110062899
Taste disorder 92.75 10.10 553 492311 64834 110031601
Therapy cessation 92.41 10.10 42 492822 44815 110051620
Nail disorder 92.03 10.10 505 492359 57430 110039005
Grip strength decreased 91.59 10.10 642 492222 79532 110016903
Anti-cyclic citrullinated peptide antibody positive 91.37 10.10 1225 491639 180759 109915676
Fungal infection 90.83 10.10 57 492807 50749 110045686
Rheumatoid factor positive 90.40 10.10 941 491923 130699 109965736
Hemiplegia 89.83 10.10 264 492600 22518 110073917
Helicobacter infection 89.56 10.10 1220 491644 180657 109915778
Hepatojugular reflux 89.55 10.10 50 492814 685 110095750
Neurologic neglect syndrome 88.30 10.10 153 492711 9145 110087290
Urinary tract infection 88.04 10.10 979 491885 325303 109771132
Pain 87.91 10.10 3424 489440 951531 109144904
Systemic lupus erythematosus 87.31 10.10 1606 491258 252732 109843703
Feeling abnormal 87.30 10.10 461 492403 180250 109916185
Oedema peripheral 87.04 10.10 1997 490867 326663 109769772
Blood pressure increased 86.80 10.10 1626 491238 256747 109839688
Live birth 86.30 10.10 568 492296 68916 110027519
C-reactive protein abnormal 86.19 10.10 921 491943 128774 109967661
Injection site swelling 85.89 10.10 89 492775 61701 110034734
Hand deformity 85.88 10.10 1410 491454 217096 109879339
Carotid artery thrombosis 85.60 10.10 154 492710 9484 110086951
Sciatica 85.40 10.10 704 492160 91695 110004740
Respiratory depression 85.34 10.10 19 492845 31982 110064453
Muscular weakness 85.32 10.10 1569 491295 246899 109849536
Bacteraemia 85.30 10.10 41 492823 42349 110054086
Electrocardiogram abnormal 83.75 10.10 227 492637 18482 110077953
Folliculitis 83.12 10.10 1126 491738 166527 109929908
Dry skin 82.96 10.10 227 492637 107426 109989009
Plasma cell myeloma 82.67 10.10 95 492769 62841 110033594
Abortion spontaneous 82.55 10.10 25 492839 34257 110062178
Adjustment disorder with depressed mood 82.54 10.10 401 492463 43482 110052953
Cardiac failure chronic 82.37 10.10 187 492677 13624 110082811
Onychomadesis 81.44 10.10 411 492453 45252 110051183
Neurotoxicity 80.20 10.10 44 492820 42163 110054272
Erectile dysfunction 79.94 10.10 222 492642 18334 110078101
Dry mouth 79.60 10.10 1293 491571 198655 109897780
Lung disorder 79.56 10.10 1185 491679 178862 109917573
Drug withdrawal syndrome 79.38 10.10 35 492829 38019 110058416
Glossodynia 79.06 10.10 1410 491454 220594 109875841
Flushing 78.38 10.10 224 492640 104512 109991923
Bronchopulmonary aspergillosis 77.12 10.10 19 492845 29844 110066591
Illness 76.28 10.10 157 492707 82014 110014421
Rheumatoid arthritis 76.08 10.10 1810 491054 297803 109798632
Incorrect dose administered 75.85 10.10 224 492640 103417 109993018
Surgery 75.64 10.10 45 492819 41238 110055197
Bronchitis 75.62 10.10 401 492463 156631 109939804
Acute coronary syndrome 75.59 10.10 251 492613 22861 110073574
Transplant rejection 75.57 10.10 10 492854 24557 110071878
Multiple sclerosis relapse 74.89 10.10 68 492796 50172 110046263
Eye irritation 74.28 10.10 28 492836 33424 110063011
Osteoarthritis 74.20 10.10 1185 491679 181438 109914997
Dry eye 73.52 10.10 84 492780 55709 110040726
Septic shock 72.70 10.10 408 492456 157120 109939315
Blister 72.62 10.10 1420 491444 225956 109870479
No adverse event 72.06 10.10 137 492727 73702 110022733
Pallor 71.59 10.10 464 492400 56003 110040432
Benign prostatic hyperplasia 69.71 10.10 209 492655 18025 110078410
Dislocation of vertebra 69.37 10.10 381 492483 43340 110053095
X-ray abnormal 69.33 10.10 345 492519 37772 110058663
Prescribed underdose 69.31 10.10 513 492351 64661 110031774
Pancytopenia 69.10 10.10 599 492265 209014 109887421
Thrombocytopenia 68.96 10.10 1116 491748 347769 109748666
Staphylococcal infection 68.94 10.10 129 492735 69815 110026620
C-reactive protein increased 68.94 10.10 1359 491505 216560 109879875
Cerebral haemorrhage 68.87 10.10 511 492353 64457 110031978
Herpes zoster 68.42 10.10 250 492614 108129 109988306
Sedation 68.26 10.10 129 492735 69554 110026881
Ventricular arrhythmia 67.44 10.10 143 492721 9944 110086491
Product dose omission in error 66.79 10.10 12 492852 23500 110072935
Epilepsy 66.76 10.10 712 492152 99497 109996938
Memory impairment 66.32 10.10 1240 491624 195704 109900731
Therapeutic response unexpected 65.96 10.10 13 492851 23830 110072605
Acute respiratory distress syndrome 65.95 10.10 84 492780 53114 110043321
Intentional product misuse 65.89 10.10 336 492528 132568 109963867
Malignant melanoma in situ 65.62 10.10 80 492784 3462 110092973
Gait inability 65.58 10.10 911 491953 135465 109960970
Dystonia 65.52 10.10 17 492847 25788 110070647
Myocardial infarction 64.89 10.10 1210 491654 190873 109905562
Bradyarrhythmia 64.55 10.10 94 492770 4840 110091595
Therapy partial responder 64.32 10.10 43 492821 37018 110059417
Glomerular filtration rate decreased 63.65 10.10 277 492587 28679 110067756
Fatigue 63.36 10.10 4616 488248 1211342 108885093
Cytomegalovirus viraemia 63.23 10.10 4 492860 17760 110078675
Therapeutic drug monitoring analysis not performed 63.19 10.10 59 492805 1872 110094563
Bone marrow failure 63.13 10.10 100 492764 57748 110038687
Adjustment disorder 63.09 10.10 145 492719 10650 110085785
Drug dependence 63.04 10.10 78 492786 49942 110046493
Coronary artery disease 62.95 10.10 540 492324 71150 110025285
Device issue 62.77 10.10 38 492826 34497 110061938
Cytomegalovirus infection reactivation 62.74 10.10 5 492859 18328 110078107
Jaundice 62.27 10.10 465 492399 58771 110037664
Left ventricular dysfunction 62.16 10.10 238 492626 23255 110073180
Palatal oedema 61.61 10.10 55 492809 1645 110094790
Retinitis 61.23 10.10 296 492568 32031 110064404
Lower limb fracture 60.72 10.10 557 492307 74791 110021644
Disseminated intravascular coagulation 60.22 10.10 57 492807 41229 110055206
Haematemesis 59.89 10.10 460 492404 58648 110037787
Haemophagocytic lymphohistiocytosis 59.82 10.10 33 492831 31526 110064909
Personality disorder 59.73 10.10 158 492706 12679 110083756
Loss of consciousness 59.68 10.10 1217 491647 195089 109901346
Graft versus host disease 59.44 10.10 7 492857 18799 110077636
Device difficult to use 59.44 10.10 7 492857 18798 110077637
International normalised ratio increased 58.49 10.10 618 492246 86154 110010281
Irritable bowel syndrome 58.46 10.10 1043 491821 163172 109933263
Injection site rash 58.37 10.10 16 492848 23403 110073032
Lip oedema 58.23 10.10 114 492750 7486 110088949
Vertigo 57.76 10.10 617 492247 86253 110010182
Encephalopathy 57.29 10.10 178 492686 80877 110015558
Cellulitis 57.27 10.10 328 492536 125688 109970747
Post transplant lymphoproliferative disorder 57.16 10.10 3 492861 15610 110080825
Naevus flammeus 57.13 10.10 19 492845 60 110096375
Prescribed overdose 56.82 10.10 619 492245 86962 110009473
Epstein-Barr virus infection 56.75 10.10 8 492856 18730 110077705
Injury 56.57 10.10 1107 491757 176158 109920277
Pancreatitis acute 56.10 10.10 460 492404 59814 110036621
Urogenital haemorrhage 55.79 10.10 41 492823 923 110095512
Basilar artery thrombosis 55.24 10.10 30 492834 388 110096047
Injection site bruising 54.64 10.10 90 492774 51173 110045262
Pneumocystis jirovecii pneumonia 54.53 10.10 66 492798 42669 110053766
Brain stem stroke 53.94 10.10 37 492827 744 110095691
Neoplasm progression 53.76 10.10 131 492733 64464 110031971
Mydriasis 53.64 10.10 16 492848 22141 110074294
Lymphocyte count decreased 53.45 10.10 109 492755 57134 110039301
Hypogammaglobulinaemia 53.37 10.10 12 492852 20064 110076371
Foetal death 53.21 10.10 5 492859 16040 110080395
Inflammation 52.62 10.10 1179 491685 192059 109904376
Pemphigoid 52.43 10.10 200 492664 19507 110076928
Suspected suicide 52.42 10.10 4 492860 15195 110081240
Aspartate aminotransferase increased 52.27 10.10 458 492406 159478 109936957
Onychomycosis 52.18 10.10 322 492542 38209 110058226
Pneumonia bacterial 51.93 10.10 26 492838 26235 110070200
Product quality issue 51.85 10.10 550 492314 76749 110019686
Haematuria 51.71 10.10 582 492282 82423 110014012
Pulmonary alveolar haemorrhage 51.68 10.10 13 492851 20137 110076298
Clostridium difficile infection 51.50 10.10 96 492768 52033 110044402
Multiple sclerosis 51.49 10.10 25 492839 25673 110070762
Product label confusion 51.43 10.10 219 492645 22458 110073977
Ventricular hypokinesia 51.14 10.10 137 492727 11077 110085358
Motor dysfunction 51.02 10.10 230 492634 24176 110072259
Coronary artery stenosis 51.00 10.10 156 492708 13602 110082833
Cytopenia 50.85 10.10 36 492828 30080 110066355
Full blood count decreased 50.83 10.10 41 492823 32058 110064377
Injection site urticaria 50.64 10.10 8 492856 17207 110079228
Mitral valve incompetence 50.59 10.10 287 492577 33042 110063393
Radiculopathy 50.52 10.10 12 492852 19324 110077111
Palpitations 50.37 10.10 993 491871 158219 109938216
Interstitial lung disease 50.09 10.10 389 492475 138945 109957490
Occult blood 50.04 10.10 51 492813 1805 110094630
Thrombosis 49.83 10.10 282 492582 108380 109988055
Oxygen saturation decreased 49.79 10.10 453 492411 156529 109939906
Nephritic syndrome 49.79 10.10 30 492834 478 110095957
Product use in unapproved indication 49.78 10.10 1566 491298 445811 109650624
Bundle branch block left 49.53 10.10 148 492716 12740 110083695
Dysarthria 49.35 10.10 583 492281 83538 110012897
Premature delivery 48.67 10.10 39 492825 30593 110065842
Dyspnoea at rest 48.66 10.10 112 492752 8234 110088201
Neuroleptic malignant syndrome 48.54 10.10 48 492816 34011 110062424
Breath sounds abnormal 48.39 10.10 233 492631 25171 110071264
Eosinophilic bronchitis 48.31 10.10 31 492833 555 110095880
Macular degeneration 48.30 10.10 18 492846 21641 110074794
Sleep disorder 48.27 10.10 1193 491671 197451 109898984
Device leakage 48.26 10.10 7 492857 16041 110080394
Aspergillus infection 48.24 10.10 27 492837 25589 110070846
Congestive cardiomyopathy 47.91 10.10 156 492708 14063 110082372
Exostosis 47.88 10.10 360 492504 45596 110050839
Coordination abnormal 47.78 10.10 231 492633 24997 110071438
Intentional dose omission 47.71 10.10 15 492849 20065 110076370
Drug dose omission by device 46.90 10.10 5 492859 14511 110081924
Malnutrition 46.87 10.10 32 492832 27247 110069188
Oral herpes 46.80 10.10 55 492809 36025 110060410
Multiple organ dysfunction syndrome 46.73 10.10 441 492423 151269 109945166
Burns second degree 46.44 10.10 105 492759 7628 110088807
Myositis 45.95 10.10 266 492598 30850 110065585
Inappropriate schedule of product administration 45.85 10.10 635 492229 203002 109893433
Acne 45.78 10.10 49 492815 33471 110062964
Anhedonia 45.77 10.10 7 492857 15421 110081014
Orthostatic intolerance 45.71 10.10 52 492812 2089 110094346
Haematoma 45.47 10.10 429 492435 58047 110038388
Dyspnoea 45.20 10.10 5612 487252 1101260 108995175
Sedation complication 45.13 10.10 16 492848 19839 110076596
Temperature intolerance 44.57 10.10 5 492859 13945 110082490
Catarrh 44.51 10.10 100 492764 7235 110089200
Asthenia 44.46 10.10 3606 489258 685393 109411042
Rash 44.35 10.10 3106 489758 817858 109278577
Pathogen resistance 44.19 10.10 12 492852 17660 110078775
Hyponatraemic syndrome 44.11 10.10 33 492831 764 110095671
Exposure via skin contact 43.86 10.10 4 492860 13143 110083292
Systolic dysfunction 43.70 10.10 74 492790 4341 110092094
Posterior reversible encephalopathy syndrome 43.52 10.10 52 492812 33809 110062626
Influenza 43.38 10.10 513 492351 168588 109927847
Contraindicated product administered 43.38 10.10 1430 491434 246837 109849598
Procedural pain 43.22 10.10 57 492807 35508 110060927
Central nervous system mass 42.78 10.10 33 492831 801 110095634
Pulmonary toxicity 42.62 10.10 13 492851 17733 110078702
Wall motion score index abnormal 42.53 10.10 33 492831 808 110095627
Degenerative mitral valve disease 42.04 10.10 23 492841 302 110096133
Musculoskeletal stiffness 42.01 10.10 1584 491280 278238 109818197
Lymphadenopathy 41.79 10.10 145 492719 63690 110032745
Electrocardiogram Q wave abnormal 41.61 10.10 31 492833 713 110095722
Poisoning 41.50 10.10 41 492823 29064 110067371
Computerised tomogram coronary artery abnormal 41.49 10.10 18 492846 136 110096299
Pneumothorax 41.41 10.10 58 492806 35227 110061208
Exercise tolerance decreased 41.21 10.10 133 492731 11934 110084501
Breast cancer female 41.04 10.10 4 492860 12464 110083971
Colitis 40.96 10.10 277 492587 102046 109994389
Diabetic metabolic decompensation 40.93 10.10 67 492797 3822 110092613
Atrioventricular block first degree 40.88 10.10 148 492716 14077 110082358
Product storage error 40.78 10.10 23 492841 21705 110074730
Affect lability 40.75 10.10 178 492686 18459 110077976
Laryngitis 40.73 10.10 326 492538 42085 110054350
Transient ischaemic attack 40.48 10.10 450 492414 63532 110032903
Oral candidiasis 40.30 10.10 87 492777 44673 110051762
Candida infection 40.24 10.10 97 492767 47912 110048523
Dermatitis atopic 39.98 10.10 33 492831 25508 110070927
Tumour lysis syndrome 39.90 10.10 47 492817 30754 110065681
Seasonal allergy 39.80 10.10 19 492845 19703 110076732
Emotional distress 39.69 10.10 88 492776 44759 110051676
Blood creatine phosphokinase increased 39.63 10.10 499 492365 72578 110023857
Chest pain 39.57 10.10 2054 490810 374321 109722114
Paraesthesia 39.54 10.10 1557 491307 274964 109821471
Infection 39.51 10.10 1271 491593 360929 109735506
Subcutaneous drug absorption impaired 39.50 10.10 98 492766 7561 110088874
Renin increased 39.49 10.10 23 492841 343 110096092
Pharyngitis streptococcal 39.44 10.10 6 492858 13271 110083164
Pain in jaw 39.36 10.10 108 492756 51069 110045366
Pulmonary mass 39.28 10.10 66 492798 37235 110059200
Multiple-drug resistance 39.27 10.10 6 492858 13229 110083206
Airway remodelling 39.24 10.10 33 492831 909 110095526
Hepatotoxicity 38.87 10.10 148 492716 63252 110033183
Hypoalbuminaemia 38.85 10.10 43 492821 28931 110067504
Hypertension 38.63 10.10 2704 490160 507380 109589055
Inferior vena cava dilatation 38.49 10.10 33 492831 934 110095501
Osteomyelitis 38.32 10.10 65 492799 36535 110059900
Heart rate increased 38.19 10.10 433 492431 143401 109953034
Middle insomnia 38.05 10.10 22 492842 20480 110075955
Porphyria acute 37.78 10.10 175 492689 18605 110077830
Hypersensitivity myocarditis 37.61 10.10 22 492842 331 110096104
Sensory loss 37.47 10.10 192 492672 21265 110075170
Vaginal haemorrhage 37.30 10.10 34 492830 25040 110071395
Atopy 37.26 10.10 35 492829 1119 110095316
Synovitis 37.26 10.10 1535 491329 272557 109823878
Grip strength 37.07 10.10 107 492757 9034 110087401
Immune effector cell-associated neurotoxicity syndrome 37.03 10.10 10 492854 14772 110081663
Atelectasis 36.81 10.10 67 492797 36645 110059790
Pulmonary arterial hypertension 36.78 10.10 55 492809 32513 110063922
Nephrolithiasis 36.56 10.10 161 492703 66051 110030384
Acute graft versus host disease in skin 36.56 10.10 3 492861 10737 110085698
Disease recurrence 36.55 10.10 143 492721 60641 110035794
Anuria 36.55 10.10 209 492655 24132 110072303
Cardiovascular insufficiency 36.45 10.10 58 492806 3230 110093205
Metastases to bone 36.39 10.10 52 492812 31320 110065115
Hospice care 36.23 10.10 6 492858 12467 110083968
Myelodysplastic syndrome 36.18 10.10 70 492794 37414 110059021
Mucosal inflammation 36.17 10.10 265 492599 95876 110000559
Dysphonia 35.93 10.10 195 492669 75734 110020701
Potentiating drug interaction 35.92 10.10 124 492740 11519 110084916
Wheezing 35.53 10.10 1433 491431 253797 109842638
Eye pain 35.42 10.10 110 492754 49989 110046446
Mucosal dryness 35.19 10.10 66 492798 4197 110092238
Hypersomnia 35.10 10.10 44 492820 28017 110068418
Back injury 35.01 10.10 344 492520 47055 110049380
Adenovirus infection 34.98 10.10 4 492860 10990 110085445
Blood creatine increased 34.93 10.10 122 492742 11399 110085036
Cerebral artery thrombosis 34.75 10.10 40 492824 1628 110094807
C-reactive protein 34.70 10.10 243 492621 30088 110066347
BK virus infection 34.51 10.10 8 492856 13098 110083337
Pneumonia aspiration 34.50 10.10 216 492648 81017 110015418
Acute respiratory failure 34.13 10.10 196 492668 75064 110021371
Cardiac septal defect 34.09 10.10 31 492833 950 110095485
Abnormal loss of weight 34.08 10.10 112 492752 10145 110086290
Impaired healing 34.08 10.10 1132 491732 195585 109900850
Urosepsis 34.07 10.10 244 492620 30431 110066004
Blood potassium decreased 34.04 10.10 125 492739 53989 110042446
Ocular hyperaemia 34.03 10.10 78 492786 39208 110057227
Skin haemorrhage 33.95 10.10 208 492656 24619 110071816
Aplastic anaemia 33.79 10.10 35 492829 24273 110072162
Change of bowel habit 33.74 10.10 52 492812 2817 110093618
Orthopnoea 33.67 10.10 117 492747 10904 110085531
Vaginal discharge 33.55 10.10 19 492845 17889 110078546
Withdrawal syndrome 33.53 10.10 55 492809 31325 110065110
Rhinovirus infection 33.52 10.10 6 492858 11783 110084652
Insurance issue 33.42 10.10 4 492860 10608 110085827
Arthralgia 33.35 10.10 3006 489858 776626 109319809
Hot flush 33.26 10.10 166 492698 65870 110030565
Hypovolaemic shock 33.20 10.10 141 492723 14442 110081993
Muscle spasms 33.20 10.10 1537 491327 276620 109819815
Proctitis 33.11 10.10 17 492847 16910 110079525
Lupus-like syndrome 33.09 10.10 302 492562 40490 110055945
Cystitis haemorrhagic 33.06 10.10 7 492857 12202 110084233
Granulocytopenia 33.01 10.10 8 492856 12707 110083728
Drug effective for unapproved indication 32.92 10.10 11 492853 14156 110082279
Hip arthroplasty 32.82 10.10 387 492477 55426 110041009
Drug use disorder 32.69 10.10 20 492844 18054 110078381
Metastases to lymph nodes 32.68 10.10 13 492851 15019 110081416
Cholestasis 32.65 10.10 435 492429 64083 110032352
Diabetes mellitus inadequate control 32.59 10.10 236 492628 29539 110066896
Metastases to liver 32.51 10.10 68 492796 35318 110061117
Failure to thrive 32.50 10.10 10 492854 13564 110082871
Nocturia 32.49 10.10 156 492708 16834 110079601
Pseudomonas infection 32.47 10.10 46 492818 27807 110068628
Carotid artery stenosis 32.46 10.10 103 492761 9160 110087275
Upper-airway cough syndrome 32.42 10.10 15 492849 15842 110080593
Tenosynovitis 32.38 10.10 16 492848 16267 110080168
Irritability 32.38 10.10 107 492757 47702 110048733
Steroid dependence 32.31 10.10 97 492767 8372 110088063
Angina unstable 32.24 10.10 152 492712 16280 110080155
Product complaint 32.20 10.10 11 492853 13961 110082474
Immune reconstitution inflammatory syndrome 32.18 10.10 16 492848 16210 110080225
Cardiac failure congestive 32.18 10.10 476 492388 150524 109945911
Aphasia 32.05 10.10 403 492461 58594 110037841
Gingival hypertrophy 32.02 10.10 64 492800 4267 110092168
Psychotic disorder 31.81 10.10 118 492746 50819 110045616
Pulmonary thrombosis 31.80 10.10 11 492853 13852 110082583
Haemodialysis complication 31.61 10.10 20 492844 349 110096086
Brain scan abnormal 31.60 10.10 37 492827 1534 110094901
Sickle cell anaemia with crisis 31.59 10.10 3 492861 9542 110086893
Ascites 31.56 10.10 263 492601 92545 110003890
Cerebrovascular accident 31.35 10.10 1043 491821 180241 109916194
Arthropathy 31.21 10.10 1574 491290 285948 109810487
Cushingoid 31.14 10.10 7 492857 11705 110084730
Burning sensation 30.99 10.10 181 492683 69031 110027404
Euglycaemic diabetic ketoacidosis 30.95 10.10 118 492746 11505 110084930
Food allergy 30.94 10.10 26 492838 19922 110076513
Body temperature increased 30.84 10.10 132 492732 54581 110041854
Deep vein thrombosis 30.49 10.10 439 492425 139448 109956987
Acute myeloid leukaemia 30.38 10.10 79 492785 38031 110058404
Neoplasm malignant 30.38 10.10 76 492788 37067 110059368
Pancreatitis necrotising 30.09 10.10 72 492792 5429 110091006
Bone density decreased 30.08 10.10 17 492847 16025 110080410
Coma 30.06 10.10 358 492506 117511 109978924
Osteonecrosis 30.03 10.10 66 492798 33675 110062760
Product preparation error 29.95 10.10 6 492858 10873 110085562
Carotid arteriosclerosis 29.95 10.10 51 492813 3006 110093429
Hypoglycaemic coma 29.81 10.10 72 492792 5461 110090974
Erysipelas 29.79 10.10 127 492737 13031 110083404
Device breakage 29.78 10.10 12 492852 13757 110082678
Haematotoxicity 29.71 10.10 30 492834 21052 110075383
Device use error 29.70 10.10 3 492861 9086 110087349
Ulcer haemorrhage 29.55 10.10 187 492677 22384 110074051
Hip fracture 29.48 10.10 71 492793 35080 110061355
Hypomania 29.46 10.10 5 492859 10205 110086230
Atrioventricular block 29.46 10.10 151 492713 16726 110079709
Colitis microscopic 29.34 10.10 128 492736 13266 110083169
Hypervolaemia 29.33 10.10 117 492747 49343 110047092
Tremor 29.20 10.10 682 492182 201550 109894885
Red blood cell count decreased 29.19 10.10 173 492691 65750 110030685
Breast cancer stage II 28.83 10.10 215 492649 27160 110069275
Venoocclusive liver disease 28.68 10.10 16 492848 15191 110081244
Finger deformity 28.38 10.10 248 492616 32844 110063591
Brain oedema 28.37 10.10 60 492804 31038 110065397
Pelvic pain 28.34 10.10 18 492846 15924 110080511
Spinal operation 28.29 10.10 7 492857 10965 110085470
Hypopnoea 28.25 10.10 113 492751 11267 110085168
Walking aid user 28.17 10.10 200 492664 24875 110071560
Tachyarrhythmia 28.17 10.10 91 492773 8170 110088265
Parosmia 28.14 10.10 125 492739 13055 110083380
Intentional overdose 28.12 10.10 418 492446 132083 109964352
Gastritis erosive 28.08 10.10 117 492747 11883 110084552
Analgesic drug level above therapeutic 28.00 10.10 21 492843 488 110095947
Throat irritation 27.91 10.10 133 492731 53419 110043016
Hepatic cirrhosis 27.89 10.10 440 492424 67186 110029249
Ocular myasthenia 27.86 10.10 25 492839 753 110095682
Hepatic enzyme increased 27.84 10.10 1721 491143 319171 109777264
Blood bilirubin increased 27.82 10.10 211 492653 75761 110020674
Gravitational oedema 27.55 10.10 38 492826 1860 110094575
Pneumonitis 27.34 10.10 214 492650 76317 110020118
Rebound effect 27.32 10.10 16 492848 14790 110081645
Injection site discolouration 27.30 10.10 4 492860 9099 110087336
Nausea 27.28 10.10 4971 487893 1230719 108865716
Headache 27.18 10.10 3481 489383 878896 109217539
Pulmonary valve disease 27.17 10.10 18 492846 341 110096094
Hypocholesterolaemia 26.85 10.10 76 492788 6345 110090090
Body height decreased 26.74 10.10 7 492857 10556 110085879
Cerebral haematoma 26.66 10.10 99 492765 9533 110086902
Hyperammonaemia 26.55 10.10 14 492850 13718 110082717
Migraine 26.54 10.10 975 491889 170677 109925758
Femur fracture 26.49 10.10 105 492759 44364 110052071
Pulmonary vascular disorder 26.31 10.10 28 492836 1043 110095392
Palmar-plantar erythrodysaesthesia syndrome 26.31 10.10 94 492770 40931 110055504
Pleural effusion 26.30 10.10 597 492267 177112 109919323
Graft versus host disease in skin 26.27 10.10 3 492861 8251 110088184
Obstructive pancreatitis 26.26 10.10 30 492834 1211 110095224
Therapeutic response shortened 26.22 10.10 58 492806 29525 110066910
Renal impairment 26.21 10.10 1058 491806 187387 109909048
Discomfort 26.17 10.10 1189 491675 213518 109882917
Altered state of consciousness 26.17 10.10 150 492714 57476 110038959
Leukopenia 26.13 10.10 486 492378 148305 109948130
Suicidal ideation 26.04 10.10 280 492584 93657 110002778
Dyspnoea exertional 25.88 10.10 627 492237 103433 109993002
Intentional product use issue 25.85 10.10 1352 491512 246554 109849881
Rash vesicular 25.51 10.10 131 492733 14521 110081914
Haematocrit decreased 25.47 10.10 181 492683 65936 110030499
Actinic elastosis 25.41 10.10 10 492854 57 110096378
Erythema 25.39 10.10 1051 491813 290396 109806039
Cardiac arrest 25.30 10.10 675 492189 196078 109900357
Vomiting 25.18 10.10 4517 488347 906158 109190277
Dyspepsia 25.15 10.10 1066 491798 189899 109906536
Transfusion 25.08 10.10 47 492817 25425 110071010
Delusion 25.04 10.10 42 492822 23713 110072722
Depressed level of consciousness 24.95 10.10 351 492513 111927 109984508
Road traffic accident 24.89 10.10 641 492223 106757 109989678
Physical examination abnormal 24.89 10.10 20 492844 516 110095919
Helicobacter gastritis 24.78 10.10 43 492821 2573 110093862
Basal ganglia haemorrhage 24.74 10.10 36 492828 1852 110094583
Complication associated with device 24.57 10.10 32 492832 20041 110076394
Oedema 24.56 10.10 1158 491706 208818 109887617
Antidepressant drug level above therapeutic 24.52 10.10 23 492841 734 110095701
Drug tolerance decreased 24.46 10.10 208 492656 27332 110069103
Pneumonia fungal 24.44 10.10 18 492846 14736 110081699
Delirium 24.41 10.10 781 492083 134244 109962191
Red blood cell sedimentation rate increased 24.30 10.10 487 492377 77815 110018620
Sinus bradycardia 24.28 10.10 219 492645 29264 110067171
Pruritus 24.15 10.10 2247 490617 579313 109517122
Oropharyngeal discomfort 24.03 10.10 8 492856 10319 110086116
Low density lipoprotein abnormal 23.96 10.10 20 492844 545 110095890
Metabolic acidosis 23.91 10.10 598 492266 99146 109997289
Ammonia increased 23.90 10.10 4 492860 8246 110088189
Gamma-glutamyltransferase increased 23.83 10.10 395 492469 60914 110035521
Sputum discoloured 23.79 10.10 56 492808 27889 110068546
Blood calcium decreased 23.75 10.10 81 492783 35764 110060671
Limb injury 23.63 10.10 87 492777 37549 110058886
Breast cancer 23.61 10.10 90 492774 38452 110057983
Fear 23.54 10.10 42 492822 23151 110073284
Pericardial disease 23.48 10.10 22 492842 701 110095734
Drug hypersensitivity 23.48 10.10 1724 491140 452366 109644069
Anti-cyclic citrullinated peptide antibody 23.46 10.10 161 492703 19803 110076632
Leukocytosis 23.44 10.10 142 492722 53686 110042749
Infusion site erythema 23.41 10.10 12 492852 11947 110084488
Akathisia 23.39 10.10 25 492839 17088 110079347
Methaemoglobinaemia 23.35 10.10 6 492858 9162 110087273
Bone pain 23.33 10.10 182 492682 64951 110031484
Nocardiosis 23.14 10.10 3 492861 7483 110088952
Labile hypertension 22.95 10.10 20 492844 579 110095856
Carpal tunnel syndrome 22.90 10.10 41 492823 22569 110073866
Gingival pain 22.90 10.10 134 492730 15602 110080833
Ankle fracture 22.84 10.10 33 492831 19786 110076649
Immune-mediated myositis 22.80 10.10 70 492794 6116 110090319
Neuritis 22.79 10.10 3 492861 7396 110089039
Mucosal haemorrhage 22.78 10.10 45 492819 2975 110093460
Toothache 22.77 10.10 44 492820 23531 110072904
Alcohol poisoning 22.74 10.10 90 492774 8930 110087505
Herpes simplex 22.71 10.10 22 492842 15742 110080693
Clostridium difficile colitis 22.65 10.10 109 492755 43669 110052766
Drug-disease interaction 22.64 10.10 35 492829 1901 110094534
Product administration interrupted 22.60 10.10 11 492853 11281 110085154
Therapeutic product effect incomplete 22.59 10.10 793 492071 223012 109873423
Blood lactate dehydrogenase increased 22.59 10.10 111 492753 44223 110052212
Knee arthroplasty 22.56 10.10 411 492453 64537 110031898
Sinusitis 22.55 10.10 1086 491778 295602 109800833
Demyelination 22.48 10.10 7 492857 9422 110087013
Hepatic enzyme 22.47 10.10 62 492802 5101 110091334
Hypercreatinaemia 22.38 10.10 17 492847 403 110096032
Pulmonary hypertension 22.34 10.10 149 492715 55071 110041364
Polyp 22.34 10.10 96 492768 9884 110086551
Malignant spinal cord compression 22.18 10.10 12 492852 154 110096281
Obsessive-compulsive disorder 22.15 10.10 3 492861 7238 110089197
Ill-defined disorder 22.12 10.10 882 491982 155971 109940464
Right ventricular failure 22.10 10.10 52 492812 25902 110070533
Kidney infection 22.03 10.10 51 492813 25548 110070887
Hemianopia 21.95 10.10 43 492821 2825 110093610
Feeling jittery 21.85 10.10 20 492844 14702 110081733
Inappropriate antidiuretic hormone secretion 21.83 10.10 239 492625 33612 110062823
Neuroglycopenia 21.79 10.10 26 492838 1100 110095335
Duodenitis 21.78 10.10 90 492774 9106 110087329
Metastases to central nervous system 21.68 10.10 43 492821 22774 110073661
Emotional disorder 21.65 10.10 24 492840 16136 110080299
Chronic sinusitis 21.57 10.10 50 492814 25034 110071401
Mouth swelling 21.55 10.10 77 492787 7277 110089158
Hepatic encephalopathy 21.45 10.10 60 492804 28196 110068239
Enterocolitis 21.40 10.10 32 492832 18917 110077518
Decreased immune responsiveness 21.39 10.10 8 492856 9598 110086837
Hydronephrosis 21.36 10.10 37 492827 20628 110075807
Atrioventricular block complete 21.31 10.10 158 492706 19924 110076511
Fluid retention 21.24 10.10 294 492570 94013 110002422
Alanine aminotransferase increased 21.20 10.10 640 492224 183133 109913302
Neurological symptom 21.11 10.10 23 492841 15585 110080850
Infusion site pain 21.08 10.10 28 492836 17391 110079044
Adverse reaction 20.99 10.10 213 492651 29381 110067054
Osteopenia 20.98 10.10 42 492822 22167 110074268
Injection site haemorrhage 20.96 10.10 76 492788 32952 110063483
Lymphoma 20.95 10.10 36 492828 20135 110076300
Productive cough 20.81 10.10 371 492493 113934 109982501
Urine analysis abnormal 20.76 10.10 3 492861 6894 110089541
Infusion site swelling 20.73 10.10 9 492855 9868 110086567
Melanoderma 20.69 10.10 17 492847 453 110095982
Stenosis 20.68 10.10 46 492818 3305 110093130
Metastases to lung 20.62 10.10 45 492819 23018 110073417
Haemoglobin decreased 20.60 10.10 902 491962 247825 109848610
Small intestinal obstruction 20.53 10.10 74 492790 32139 110064296
Nasal oedema 20.53 10.10 3 492861 6836 110089599
Swelling face 20.52 10.10 548 492316 91773 110004662
Generalised tonic-clonic seizure 20.43 10.10 151 492713 54529 110041906
Alanine aminotransferase abnormal 20.41 10.10 8 492856 9326 110087109
Glomerular filtration rate 20.37 10.10 12 492852 183 110096252
Sleep disorder due to general medical condition, hypersomnia type 20.20 10.10 34 492830 1985 110094450
Heavy menstrual bleeding 20.12 10.10 26 492838 16339 110080096
Idiopathic angioedema 20.10 10.10 9 492855 74 110096361
Tuberculosis 20.09 10.10 30 492834 17744 110078691
Pharyngitis 20.03 10.10 52 492812 25046 110071389
Infective exacerbation of chronic obstructive airways disease 19.93 10.10 44 492820 3146 110093289
Pustular psoriasis 19.89 10.10 116 492748 13489 110082946
Intestinal obstruction 19.88 10.10 147 492717 53080 110043355
Swollen joint count 19.85 10.10 84 492780 8590 110087845
Lymphoproliferative disorder 19.83 10.10 4 492860 7214 110089221
Premature labour 19.83 10.10 8 492856 9164 110087271
Liver function test abnormal 19.81 10.10 424 492440 68526 110027909
Ventricular dysfunction 19.79 10.10 76 492788 7435 110089000
Hyperglycaemia 19.76 10.10 508 492356 84582 110011853
Microangiopathy 19.72 10.10 42 492822 2930 110093505
Ventricular enlargement 19.71 10.10 20 492844 704 110095731
Enterococcal infection 19.68 10.10 38 492826 20328 110076107
Band neutrophil percentage decreased 19.65 10.10 6 492858 13 110096422
Cardiac aneurysm 19.65 10.10 31 492833 1714 110094721
Nephrotic syndrome 19.62 10.10 117 492747 13714 110082721
Helicobacter test positive 19.51 10.10 27 492837 1326 110095109
Dermatitis contact 19.50 10.10 20 492844 13933 110082502
Fluid intake reduced 19.50 10.10 72 492792 6914 110089521
Tricuspid valve incompetence 19.49 10.10 177 492687 23696 110072739
Cyst 19.47 10.10 27 492837 16469 110079966
Post-traumatic amnestic disorder 19.46 10.10 8 492856 52 110096383
Laryngeal oedema 19.44 10.10 91 492773 9716 110086719
Hereditary angioedema 19.43 10.10 4 492860 7110 110089325
Peritonitis 19.42 10.10 77 492787 32530 110063905
Hysterectomy 19.39 10.10 6 492858 8108 110088327
Asphyxia 19.38 10.10 119 492745 14096 110082339
Hypercapnic coma 19.34 10.10 17 492847 498 110095937
Disorientation 19.16 10.10 431 492433 70240 110026195
Amnesia 19.13 10.10 610 492254 104798 109991637
Cytomegalovirus test positive 19.12 10.10 4 492860 7032 110089403
Xyphoid retraction 19.01 10.10 11 492853 162 110096273
Pancreatic neuroendocrine tumour 19.00 10.10 22 492842 901 110095534
Paradoxical drug reaction 18.99 10.10 10 492854 9807 110086628
Hypersensitivity vasculitis 18.95 10.10 71 492793 6866 110089569
Pharyngeal necrosis 18.93 10.10 9 492855 86 110096349
Parainfluenzae virus infection 18.88 10.10 4 492860 6970 110089465
Cerebral ischaemia 18.88 10.10 105 492759 11999 110084436
Blood potassium increased 18.87 10.10 229 492635 33020 110063415
Nervous system disorder 18.83 10.10 75 492789 31646 110064789
Musculoskeletal disorder 18.83 10.10 46 492818 22618 110073817
Anxiety 18.82 10.10 1304 491560 343774 109752661
Pneumonia cytomegaloviral 18.80 10.10 4 492860 6950 110089485
Sarcoidosis 18.78 10.10 17 492847 12562 110083873
Gastrointestinal perforation 18.76 10.10 5 492859 7451 110088984
Dermatitis exfoliative 18.75 10.10 100 492764 11247 110085188
Blood cholesterol decreased 18.74 10.10 39 492825 2677 110093758
Infusion site reaction 18.69 10.10 139 492725 17543 110078892
Peripheral circulatory failure 18.69 10.10 31 492833 1788 110094647
Diabetic ketoacidosis 18.63 10.10 277 492587 41781 110054654
Peritonitis bacterial 18.58 10.10 12 492852 10521 110085914
Hypomagnesaemia 18.57 10.10 375 492489 59995 110036440
Lordosis 18.54 10.10 16 492848 457 110095978
Decubitus ulcer 18.53 10.10 33 492831 18203 110078232
Scleroderma 18.53 10.10 3 492861 6338 110090097
Tenderness 18.51 10.10 68 492796 29369 110067066
Eosinophil count decreased 18.48 10.10 64 492800 5954 110090481
Skin infection 18.45 10.10 46 492818 22463 110073972
Eye injury 18.45 10.10 76 492788 7679 110088756
Cardiac discomfort 18.38 10.10 27 492837 1401 110095034
Coma scale abnormal 18.38 10.10 89 492775 9637 110086798
Pulmonary pain 18.34 10.10 3 492861 6290 110090145
Sensitivity to weather change 18.27 10.10 11 492853 10017 110086418
Incorrect dose administered by device 18.26 10.10 4 492860 6810 110089625
Rectal polyp 18.23 10.10 28 492836 1512 110094923
Duodenal ulcer 18.19 10.10 149 492715 19365 110077070
Hypertensive angiopathy 18.16 10.10 9 492855 95 110096340
Mental disorder 18.14 10.10 100 492764 38691 110057744
Eosinophilic myocarditis 18.12 10.10 33 492831 2052 110094383
Bone erosion 18.11 10.10 299 492565 46072 110050363
Helicobacter test false negative 18.05 10.10 8 492856 64 110096371
Paresis 18.02 10.10 55 492809 4789 110091646
Tooth disorder 18.01 10.10 69 492795 29440 110066995
Anastomotic infection 17.97 10.10 10 492854 136 110096299
N-terminal prohormone brain natriuretic peptide increased 17.86 10.10 64 492800 6057 110090378
Mitral valve disease 17.85 10.10 44 492820 3381 110093054
Gastroenteritis clostridial 17.82 10.10 23 492841 1055 110095380
Central nervous system lesion 17.82 10.10 26 492838 15527 110080908
Diffuse large B-cell lymphoma 17.81 10.10 27 492837 15871 110080564
Treatment noncompliance 17.73 10.10 224 492640 72766 110023669
Hyperthyroidism 17.69 10.10 204 492660 29057 110067378
Lung neoplasm malignant 17.66 10.10 84 492780 33758 110062677
Mood swings 17.65 10.10 48 492816 22764 110073671
Erythema nodosum 17.64 10.10 4 492860 6649 110089786
Mouth breathing 17.64 10.10 13 492851 294 110096141
Bronchiectasis 17.62 10.10 244 492620 36249 110060186
Loss of proprioception 17.52 10.10 21 492843 893 110095542
Listless 17.49 10.10 52 492812 4463 110091972
Urinary hesitation 17.44 10.10 53 492811 4605 110091830
Pulmonary haemorrhage 17.44 10.10 29 492835 16427 110080008
Oesophagitis haemorrhagic 17.44 10.10 18 492846 647 110095788
Coronary arterial stent insertion 17.39 10.10 62 492802 5853 110090582
Psychogenic tremor 17.36 10.10 6 492858 22 110096413
Human herpesvirus 6 infection 17.36 10.10 4 492860 6577 110089858
Low cardiac output syndrome 17.36 10.10 23 492841 1083 110095352
Fear of injection 17.35 10.10 9 492855 8902 110087533
Epiglottic oedema 17.30 10.10 15 492849 431 110096004
Irregular sleep wake rhythm disorder 17.30 10.10 14 492850 365 110096070
Anal haemorrhage 17.29 10.10 55 492809 4897 110091538
Pneumonia pseudomonal 17.29 10.10 6 492858 7540 110088895
Bacterial infection 17.26 10.10 127 492737 45909 110050526
Feeding disorder 17.25 10.10 44 492820 21318 110075117
Nervousness 17.23 10.10 95 492769 36756 110059679
Photophobia 17.23 10.10 58 492806 25713 110070722
Full blood count abnormal 17.22 10.10 163 492701 55889 110040546
Dysuria 17.18 10.10 370 492494 59861 110036574
Post procedural haematoma 17.17 10.10 37 492827 2602 110093833
Joint swelling 17.16 10.10 2239 490625 440606 109655829
Oedema mouth 17.15 10.10 41 492823 3089 110093346
Arteriosclerotic gangrene 17.15 10.10 8 492856 73 110096362
Hypertrophy 17.13 10.10 21 492843 914 110095521
Streptococcal infection 17.13 10.10 14 492850 10876 110085559
Anaphylactic shock 17.10 10.10 147 492717 51399 110045036
Skin fissures 17.08 10.10 54 492810 24404 110072031
Conjunctivitis 16.99 10.10 85 492779 33707 110062728
Accidental overdose 16.96 10.10 325 492539 51509 110044926
Prerenal failure 16.94 10.10 51 492813 4408 110092027
Macrophages increased 16.92 10.10 12 492852 255 110096180
Left ventricular hypertrophy 16.89 10.10 109 492755 13135 110083300
Therapy change 16.81 10.10 12 492852 9985 110086450
Cold sweat 16.81 10.10 161 492703 21870 110074565
Respiratory syncytial virus infection 16.81 10.10 24 492840 14460 110081975
Cardiac disorder 16.76 10.10 239 492625 76041 110020394
Pneumonia viral 16.75 10.10 15 492849 11142 110085293
Foot fracture 16.74 10.10 58 492806 25488 110070947
Intestinal haemorrhage 16.73 10.10 71 492793 7270 110089165
Scleroedema 16.72 10.10 10 492854 157 110096278
Gastrointestinal toxicity 16.72 10.10 15 492849 11133 110085302
Pulmonary tuberculosis 16.69 10.10 10 492854 9129 110087306
Hepatic failure 16.68 10.10 211 492653 68528 110027907
Type I hypersensitivity 16.64 10.10 4 492860 6389 110090046
Skin erosion 16.60 10.10 3 492861 5851 110090584
Syringe issue 16.60 10.10 11 492853 9514 110086921
Foot deformity 16.57 10.10 306 492558 48174 110048261
Embolic stroke 16.52 10.10 80 492784 8663 110087772
Intervertebral disc degeneration 16.41 10.10 35 492829 18050 110078385
Diastolic dysfunction 16.38 10.10 103 492761 12301 110084134
Pseudomonal sepsis 16.38 10.10 10 492854 9036 110087399
Brain stem infarction 16.34 10.10 32 492832 2102 110094333
Renal injury 16.33 10.10 37 492827 18676 110077759
Upper motor neurone lesion 16.32 10.10 13 492851 331 110096104
Enthesopathy 16.21 10.10 19 492845 12459 110083976
Fungal skin infection 16.21 10.10 6 492858 7243 110089192
Micturition urgency 16.16 10.10 144 492720 19176 110077259
Anaemia macrocytic 16.16 10.10 70 492794 7233 110089202
Camptocormia 16.14 10.10 15 492849 473 110095962
Progressive multifocal leukoencephalopathy 16.12 10.10 57 492807 24899 110071536
Large intestine perforation 16.09 10.10 31 492833 16598 110079837
Pyelonephritis 16.09 10.10 58 492806 25192 110071243
Ketoacidosis 16.06 10.10 88 492776 9999 110086436
Immune system disorder 16.04 10.10 22 492842 13479 110082956
SARS-CoV-2 test positive 16.02 10.10 32 492832 16903 110079532
Rhinorrhoea 16.02 10.10 342 492522 102324 109994111
Catatonia 16.02 10.10 16 492848 11284 110085151
Fracture 15.98 10.10 175 492689 24613 110071822
Papule 15.97 10.10 13 492851 10120 110086315
Genitourinary symptom 15.96 10.10 13 492851 342 110096093
Cystitis noninfective 15.96 10.10 28 492836 1690 110094745
Endoscopic retrograde cholangiopancreatography 15.96 10.10 11 492853 223 110096212
Mitral valve hypoplasia 15.89 10.10 6 492858 30 110096405
Oral disorder 15.89 10.10 18 492846 11985 110084450
Shone complex 15.89 10.10 6 492858 30 110096405
Stupor 15.88 10.10 76 492788 8189 110088246
Product blister packaging issue 15.87 10.10 13 492851 345 110096090
Dilatation ventricular 15.85 10.10 47 492817 4028 110092407
Arterial stenosis 15.85 10.10 27 492837 1592 110094843
Stress 15.84 10.10 353 492511 104995 109991440
ECG signs of myocardial ischaemia 15.81 10.10 14 492850 414 110096021
Hypothyroidism 15.80 10.10 229 492635 72670 110023765
Gingival swelling 15.78 10.10 56 492808 5274 110091161
Hypercreatininaemia 15.78 10.10 24 492840 1285 110095150
Chronic coronary syndrome 15.78 10.10 12 492852 285 110096150
Left atrial dilatation 15.74 10.10 43 492821 3517 110092918
Congenital aortic valve stenosis 15.73 10.10 6 492858 31 110096404
Nightmare 15.70 10.10 252 492612 38611 110057824
Depressive symptom 15.66 10.10 9 492855 8405 110088030
Abnormal clotting factor 15.63 10.10 10 492854 178 110096257
Crying 15.59 10.10 60 492804 25568 110070867
Hepatitis B 15.57 10.10 12 492852 9600 110086835
Nephroangiosclerosis 15.56 10.10 14 492850 423 110096012
Abnormal weight gain 15.50 10.10 43 492821 3548 110092887
Drop attacks 15.50 10.10 22 492842 1106 110095329
Gastrointestinal pain 15.47 10.10 18 492846 11842 110084593
Fungaemia 15.47 10.10 4 492860 6082 110090353
Knee operation 15.39 10.10 6 492858 7016 110089419
Diabetic retinal oedema 15.37 10.10 14 492850 430 110096005
General symptom 15.34 10.10 79 492785 8767 110087668
Serotonin syndrome 15.34 10.10 179 492685 58974 110037461
Tongue disorder 15.33 10.10 25 492839 14273 110082162
Aorta hypoplasia 15.28 10.10 6 492858 34 110096401
Hepatitis 15.27 10.10 517 492347 89537 110006898
Intervertebral disc disorder 15.26 10.10 3 492861 5509 110090926
Gynaecomastia 15.25 10.10 83 492781 9407 110087028
Skin turgor decreased 15.25 10.10 19 492845 841 110095594
Somnolence 15.24 10.10 1130 491734 296319 109800116
Cholecystitis chronic 15.21 10.10 12 492852 9488 110086947
Intrapericardial thrombosis 15.18 10.10 7 492857 62 110096373
Lichenoid keratosis 15.18 10.10 62 492802 6240 110090195
Burning feet syndrome 15.11 10.10 11 492853 244 110096191
Overlap syndrome 15.08 10.10 80 492784 8979 110087456
Pharyngeal oedema 15.08 10.10 125 492739 16303 110080132
Left ventricular enlargement 15.06 10.10 19 492845 852 110095583
Eye infection 15 10.10 26 492838 14492 110081943
Catheter site pain 14.99 10.10 5 492859 6441 110089994
Blood osmolarity abnormal 14.99 10.10 5 492859 16 110096419
Oropharyngeal swelling 14.98 10.10 25 492839 1449 110094986
Food interaction 14.96 10.10 31 492833 2121 110094314
Traumatic intracranial haemorrhage 14.96 10.10 25 492839 1451 110094984
Arthritis 14.93 10.10 901 491963 166685 109929750
Suicide attempt 14.83 10.10 349 492515 103045 109993390
Crush syndrome 14.75 10.10 13 492851 382 110096053
Intraventricular haemorrhage 14.74 10.10 56 492808 5451 110090984
Hepatitis cholestatic 14.73 10.10 131 492733 17435 110079000
Respiratory distress 14.71 10.10 217 492647 68657 110027778
Tubulointerstitial nephritis 14.70 10.10 331 492533 53953 110042482
Jealous delusion 14.61 10.10 14 492850 459 110095976
Vaginal infection 14.60 10.10 6 492858 6798 110089637
Visual impairment 14.59 10.10 736 492128 133692 109962743
Postmenopausal haemorrhage 14.52 10.10 28 492836 1818 110094617
Eye pruritus 14.52 10.10 86 492778 32689 110063746
Oesophageal carcinoma 14.49 10.10 18 492846 11506 110084929
Congenital heart valve disorder 14.46 10.10 6 492858 40 110096395
Vitamin D decreased 14.41 10.10 20 492844 12195 110084240
Thyroiditis acute 14.41 10.10 10 492854 205 110096230
Protein urine present 14.37 10.10 18 492846 11466 110084969
Osteoma 14.37 10.10 8 492856 109 110096326
Eating disorder 14.37 10.10 205 492659 30653 110065782
Hyperlactacidaemia 14.37 10.10 74 492790 8212 110088223
Cardiac septal hypertrophy 14.36 10.10 13 492851 396 110096039
Deafness neurosensory 14.36 10.10 13 492851 9606 110086829
Drug specific antibody present 14.35 10.10 10 492854 8424 110088011
Thirst 14.34 10.10 154 492710 21553 110074882
Carcinogenicity 14.33 10.10 9 492855 155 110096280
Blood pressure diastolic decreased 14.24 10.10 232 492632 35653 110060782
Vascular access site occlusion 14.18 10.10 8 492856 112 110096323
Forced expiratory volume decreased 14.17 10.10 23 492841 13153 110083282
Fracture blisters 14.12 10.10 7 492857 74 110096361
Nicotine dependence 14.10 10.10 23 492841 1308 110095127
Klebsiella infection 14.10 10.10 44 492820 19965 110076470
Eye discharge 14.09 10.10 11 492853 8743 110087692
Appendicitis 14.08 10.10 72 492792 28392 110068043
Blood creatinine increased 14.07 10.10 971 491893 181918 109914517
Haemorrhoids 14.06 10.10 97 492767 35575 110060860
Parkinsonism 14.01 10.10 156 492708 22031 110074404
Product prescribing issue 14.01 10.10 22 492842 12750 110083685
Gout 13.99 10.10 235 492629 36331 110060104
Creatinine renal clearance decreased 13.98 10.10 50 492814 21765 110074670
Upper limb fracture 13.97 10.10 47 492817 20841 110075594
Malaise 13.97 10.10 3287 489577 668532 109427903
Oropharyngeal pain 13.95 10.10 478 492386 134798 109961637
Decreased activity 13.95 10.10 17 492847 10957 110085478
Otitis media 13.91 10.10 8 492856 7468 110088967
Arterial spasm 13.89 10.10 9 492855 164 110096271
Device related infection 13.88 10.10 111 492753 39408 110057027
Plasma cell myeloma recurrent 13.88 10.10 7 492857 7035 110089400
Splenomegaly 13.87 10.10 59 492805 24439 110071996
Respiratory tract inflammation 13.83 10.10 20 492844 1023 110095412
Haemoptysis 13.82 10.10 229 492635 71125 110025310
Hyperprolactinaemia 13.79 10.10 6 492858 6569 110089866
Chronotropic incompetence 13.76 10.10 8 492856 119 110096316
Gastritis haemorrhagic 13.71 10.10 38 492826 3135 110093300
Pneumonia staphylococcal 13.69 10.10 5 492859 6086 110090349
Skin discolouration 13.67 10.10 146 492718 48900 110047535
Antidepressant drug level below therapeutic 13.58 10.10 5 492859 23 110096412
Blood culture positive 13.56 10.10 12 492852 8964 110087471
Streptococcal sepsis 13.55 10.10 3 492861 5069 110091366
Tooth infection 13.53 10.10 52 492812 22164 110074271
Pseudocyst 13.52 10.10 12 492852 356 110096079
Diverticulitis 13.48 10.10 163 492701 53359 110043076
Polycystic liver disease 13.47 10.10 9 492855 173 110096262
Eczema nummular 13.45 10.10 13 492851 431 110096004
Toxic epidermal necrolysis 13.44 10.10 175 492689 56552 110039883
Mean cell haemoglobin concentration 13.43 10.10 6 492858 49 110096386
Pneumomediastinum 13.41 10.10 3 492861 5033 110091402
Hypochloraemia 13.39 10.10 41 492823 3577 110092858
Pneumatosis intestinalis 13.37 10.10 11 492853 8518 110087917
Hereditary haemorrhagic telangiectasia 13.34 10.10 7 492857 84 110096351
Tooth dislocation 13.33 10.10 6 492858 50 110096385
Gingival hypoplasia 13.31 10.10 4 492860 8 110096427
Joint destruction 13.31 10.10 89 492775 10854 110085581
Blood bilirubin abnormal 13.27 10.10 27 492837 1823 110094612
5-hydroxyindolacetic acid increased 13.25 10.10 8 492856 128 110096307
Congenital aortic stenosis 13.24 10.10 5 492859 25 110096410
Congenital aortic anomaly 13.24 10.10 5 492859 25 110096410
Muscle enzyme increased 13.23 10.10 14 492850 518 110095917
Red blood cell abnormality 13.22 10.10 18 492846 870 110095565
Sudden cardiac death 13.22 10.10 55 492809 5582 110090853
Therapeutic response decreased 13.21 10.10 328 492536 96171 110000264
Injection site warmth 13.18 10.10 37 492827 17368 110079067
Ear pruritus 13.18 10.10 8 492856 7252 110089183
Respiratory tract infection 13.17 10.10 232 492632 71385 110025050
Amenorrhoea 13.16 10.10 13 492851 9218 110087217
Reduced facial expression 13.16 10.10 41 492823 3610 110092825
Caesarean section 13.16 10.10 26 492838 13791 110082644
Patent ductus arteriosus 13.16 10.10 9 492855 180 110096255
Product administered to patient of inappropriate age 13.06 10.10 10 492854 8026 110088409
Oral infection 13.03 10.10 6 492858 6355 110090080
Strangury 13.02 10.10 10 492854 241 110096194
Pericardial effusion 13.02 10.10 178 492686 57039 110039396
Device failure 13 10.10 8 492856 7199 110089236
Sex hormone binding globulin increased 13.00 10.10 4 492860 9 110096426
Staphylococcal bacteraemia 12.99 10.10 35 492829 16653 110079782
Cancer pain 12.95 10.10 7 492857 6765 110089670
Fibrinolysis increased 12.93 10.10 5 492859 27 110096408
Ileus 12.90 10.10 82 492782 30647 110065788
Sinus congestion 12.87 10.10 199 492665 30260 110066175
Peripartum cardiomyopathy 12.87 10.10 9 492855 187 110096248
Accident 12.86 10.10 18 492846 10934 110085501
Urticaria 12.84 10.10 1616 491248 317241 109779194
Urogenital infection fungal 12.84 10.10 6 492858 55 110096380
Kidney transplant rejection 12.82 10.10 21 492843 11966 110084469
N-terminal prohormone brain natriuretic peptide abnormal 12.81 10.10 11 492853 312 110096123
Hyperhidrosis 12.80 10.10 693 492171 186605 109909830
Megakaryocytes increased 12.78 10.10 8 492856 137 110096298
Intestinal perforation 12.77 10.10 49 492815 20895 110075540
Polyuria 12.74 10.10 128 492736 17610 110078825
Disease complication 12.73 10.10 5 492859 5822 110090613
Blood pressure systolic decreased 12.73 10.10 103 492761 13338 110083097
Renal disorder 12.72 10.10 150 492714 49329 110047106
Haemolytic anaemia 12.72 10.10 49 492815 20871 110075564
Toxic neuropathy 12.71 10.10 20 492844 1103 110095332
Injection site extravasation 12.66 10.10 16 492848 10153 110086282
Supravalvular aortic stenosis 12.63 10.10 5 492859 29 110096406
Ventricular tachycardia 12.63 10.10 302 492562 49707 110046728
Troponin I increased 12.63 10.10 53 492811 5399 110091036
Intervertebral disc protrusion 12.63 10.10 72 492792 27626 110068809
Ocular icterus 12.62 10.10 57 492807 5996 110090439
Secretion discharge 12.57 10.10 47 492817 20197 110076238
Viral infection 12.57 10.10 164 492700 52975 110043460
Apathy 12.55 10.10 119 492745 16120 110080315
Prostatic haemorrhage 12.54 10.10 9 492855 195 110096240
Breast cancer metastatic 12.51 10.10 19 492845 11162 110085273
Bipolar disorder 12.49 10.10 13 492851 8994 110087441
Device occlusion 12.47 10.10 31 492833 15154 110081281
Oral neoplasm 12.46 10.10 9 492855 197 110096238
Hepatorenal failure 12.42 10.10 22 492842 1338 110095097
Optic neuritis 12.42 10.10 19 492845 11128 110085307
Faeces pale 12.38 10.10 38 492826 3319 110093116
Quality of life decreased 12.38 10.10 28 492836 14141 110082294
Bacterial sepsis 12.37 10.10 17 492847 10409 110086026
Meningitis cryptococcal 12.35 10.10 3 492861 4759 110091676
Atrial thrombosis 12.30 10.10 45 492819 4301 110092134
Uterine leiomyoma 12.30 10.10 10 492854 7790 110088645
Type V hyperlipidaemia 12.30 10.10 23 492841 1459 110094976
Hiatus hernia 12.30 10.10 182 492682 27424 110069011
Adrenal insufficiency 12.30 10.10 125 492739 42265 110054170
Hepatic cytolysis 12.26 10.10 172 492692 54881 110041554
Compression fracture 12.25 10.10 14 492850 9285 110087150
Mesenteric arterial occlusion 12.25 10.10 10 492854 264 110096171
Synovial cyst 12.24 10.10 20 492844 11410 110085025
Lymphorrhoea 12.23 10.10 9 492855 203 110096232
Disability 12.22 10.10 196 492668 30027 110066408
Accessory spleen 12.19 10.10 9 492855 204 110096231
Encephalitis 12.19 10.10 43 492821 18796 110077639
Hypovolaemia 12.18 10.10 149 492715 21525 110074910
Normocytic anaemia 12.09 10.10 59 492805 6408 110090027
Heart rate decreased 12.05 10.10 467 492397 82289 110014146
Transplant failure 12.04 10.10 5 492859 5630 110090805
Hepatosplenomegaly 12.04 10.10 8 492856 6911 110089524
Bone disorder 12.02 10.10 51 492813 21141 110075294
Dermatitis acneiform 12.00 10.10 24 492840 12671 110083764
Eosinophil cationic protein increased 11.97 10.10 6 492858 65 110096370
Frontotemporal dementia 11.97 10.10 15 492849 668 110095767
Oral pain 11.89 10.10 108 492756 37336 110059099
Metastases to meninges 11.88 10.10 4 492860 5124 110091311
Antinuclear antibody positive 11.87 10.10 14 492850 9154 110087281
Pharyngeal swelling 11.83 10.10 93 492771 11939 110084496
Meningitis aseptic 11.81 10.10 16 492848 9854 110086581
Impaired gastric emptying 11.79 10.10 26 492838 13249 110083186
Pulmonary embolism 11.76 10.10 810 492054 213664 109882771
Abdominal discomfort 11.76 10.10 1962 490902 391896 109704539
Tardive dyskinesia 11.73 10.10 27 492837 13552 110082883
Respiratory tract haemorrhage 11.71 10.10 27 492837 1987 110094448
Colorectal cancer 11.71 10.10 14 492850 9100 110087335
Somnambulism 11.71 10.10 7 492857 6398 110090037
Neurogenic bladder 11.70 10.10 4 492860 5075 110091360
Spinal cord haemorrhage 11.70 10.10 14 492850 594 110095841
Lumbar hernia 11.70 10.10 8 492856 160 110096275
Inadequate analgesia 11.70 10.10 4 492860 5073 110091362
Scab 11.69 10.10 26 492838 13210 110083225
Lip blister 11.68 10.10 37 492827 3288 110093147
Total lung capacity abnormal 11.67 10.10 3 492861 4580 110091855
Coarctation of the aorta 11.66 10.10 6 492858 69 110096366
Oesophageal candidiasis 11.61 10.10 21 492843 11513 110084922
Transplant dysfunction 11.57 10.10 12 492852 8316 110088119
Small fibre neuropathy 11.54 10.10 18 492846 985 110095450
Blood creatine phosphokinase abnormal 11.52 10.10 15 492849 694 110095741
Multiple drug therapy 11.50 10.10 68 492796 7946 110088489
Electrocardiogram ambulatory abnormal 11.50 10.10 5 492859 38 110096397
Radiation pneumonitis 11.49 10.10 3 492861 4533 110091902
Subclavian artery occlusion 11.49 10.10 8 492856 165 110096270
Therapeutic drug monitoring analysis incorrectly performed 11.47 10.10 15 492849 697 110095738
Ventricular tachyarrhythmia 11.47 10.10 13 492851 520 110095915
Lung abscess 11.46 10.10 4 492860 5008 110091427
Supine hypertension 11.45 10.10 12 492852 439 110095996
Accidental death 11.45 10.10 4 492860 5005 110091430
Acute abdomen 11.44 10.10 37 492827 3324 110093111
Computerised tomogram head abnormal 11.38 10.10 7 492857 116 110096319
Clostridial infection 11.36 10.10 7 492857 6295 110090140
Escherichia infection 11.36 10.10 61 492803 23755 110072680
Respiratory tract infection viral 11.35 10.10 6 492858 5872 110090563
Hyperammonaemic encephalopathy 11.33 10.10 5 492859 5429 110091006
Attention deficit hyperactivity disorder 11.32 10.10 3 492861 4488 110091947
Coagulopathy 11.31 10.10 122 492742 40789 110055646
Squamous cell carcinoma of skin 11.31 10.10 39 492825 17164 110079271
Scleritis 11.28 10.10 5 492859 5415 110091020
Therapeutic product effect delayed 11.28 10.10 3 492861 4476 110091959
Gastrointestinal angiodysplasia 11.27 10.10 20 492844 1218 110095217
Spinal disorder 11.23 10.10 22 492842 11706 110084729
Cheyne-Stokes respiration 11.22 10.10 13 492851 533 110095902
Enterococcal bacteraemia 11.21 10.10 3 492861 4458 110091977
Acquired corneal dystrophy 11.19 10.10 3 492861 3 110096432
Pacemaker generated arrhythmia 11.19 10.10 3 492861 3 110096432
Immunosuppression 11.18 10.10 41 492823 17718 110078717
Infected skin ulcer 11.17 10.10 41 492823 3926 110092509
Coronary artery dissection 11.16 10.10 20 492844 1228 110095207
Injection site irritation 11.14 10.10 4 492860 4920 110091515
Thrombotic microangiopathy 11.13 10.10 80 492784 29069 110067366
Cerebellar haemorrhage 11.12 10.10 36 492828 3235 110093200
Gastric cancer 11.11 10.10 20 492844 10988 110085447
Pneumonia klebsiella 11.10 10.10 8 492856 6624 110089811
Hypoaesthesia 11.09 10.10 1580 491284 312643 109783792
Decreased interest 11.08 10.10 4 492860 4904 110091531
Blood test abnormal 11.08 10.10 78 492786 28476 110067959
Menstruation irregular 11.08 10.10 6 492858 5791 110090644
Intermittent claudication 11.06 10.10 39 492825 3662 110092773
Viral mutation identified 11.05 10.10 3 492861 4416 110092019
Exposure via ingestion 11.05 10.10 4 492860 4896 110091539
Optic disc disorder 11.02 10.10 7 492857 123 110096312
Ventricular internal diameter abnormal 11.01 10.10 9 492855 238 110096197
Bronchomalacia 11.01 10.10 10 492854 306 110096129
Peripheral swelling 11.01 10.10 2003 490861 402031 109694404
Breast cancer stage I 11.01 10.10 10 492854 7377 110089058
Unresponsive to stimuli 11.00 10.10 209 492655 63581 110032854
Balanoposthitis 10.98 10.10 21 492843 1355 110095080
Pneumocystis jirovecii infection 10.98 10.10 3 492861 4397 110092038
Acute lymphocytic leukaemia 10.97 10.10 6 492858 5759 110090676
Psychiatric decompensation 10.97 10.10 6 492858 5759 110090676
Eosinophilia 10.97 10.10 337 492527 57599 110038836
Injury associated with device 10.94 10.10 3 492861 4386 110092049
Articular disc disorder 10.93 10.10 4 492860 18 110096417
Cerebral artery occlusion 10.92 10.10 26 492838 1954 110094481
Sputum increased 10.92 10.10 6 492858 5745 110090690
Hypoaesthesia oral 10.87 10.10 39 492825 16963 110079472
Blood pressure systolic increased 10.86 10.10 463 492401 82528 110013907
Skin weeping 10.85 10.10 39 492825 3696 110092739
Normal newborn 10.82 10.10 147 492717 21749 110074686
Tooth injury 10.81 10.10 28 492836 2218 110094217
Asthma 10.81 10.10 964 491900 249327 109847108
Drug effect less than expected 10.80 10.10 10 492854 7310 110089125
Dermatitis allergic 10.79 10.10 146 492718 21578 110074857
Conjunctivitis allergic 10.79 10.10 9 492855 6922 110089513
Pigmentation disorder 10.77 10.10 10 492854 7301 110089134
Enlarged uvula 10.71 10.10 12 492852 474 110095961
Base excess decreased 10.71 10.10 11 492853 393 110096042
Wrist fracture 10.66 10.10 31 492833 14386 110082049
Blindness 10.64 10.10 107 492757 36252 110060183
Genital infection female 10.63 10.10 6 492858 84 110096351
Splenic necrosis 10.63 10.10 8 492856 187 110096248
Fibrosis 10.63 10.10 11 492853 7631 110088804
Sneezing 10.62 10.10 201 492663 31783 110064652
Anorgasmia 10.62 10.10 23 492841 1623 110094812
Suspiciousness 10.60 10.10 15 492849 752 110095683
Autoimmune blistering disease 10.59 10.10 4 492860 20 110096415
Apheresis related complication 10.59 10.10 4 492860 20 110096415
Alveolitis necrotising 10.59 10.10 4 492860 20 110096415
Melanocytic naevus 10.59 10.10 6 492858 5648 110090787
Injection site inflammation 10.58 10.10 4 492860 4767 110091668
Dental caries 10.55 10.10 26 492838 12747 110083688
Prohormone brain natriuretic peptide increased 10.55 10.10 11 492853 400 110096035
Fistula 10.53 10.10 34 492830 15265 110081170
Pulmonary function test decreased 10.51 10.10 14 492850 8686 110087749
Sinus headache 10.46 10.10 7 492857 6025 110090410
Catheter site erythema 10.45 10.10 7 492857 6021 110090414
Jugular vein occlusion 10.45 10.10 6 492858 87 110096348
Anal paraesthesia 10.43 10.10 4 492860 21 110096414
Akinesia 10.41 10.10 38 492826 3629 110092806
Brain stem ischaemia 10.39 10.10 10 492854 330 110096105
Lipids abnormal 10.38 10.10 14 492850 671 110095764
Musculoskeletal deformity 10.36 10.10 22 492842 1531 110094904
Nerve injury 10.34 10.10 20 492844 10693 110085742
Venous pressure jugular decreased 10.33 10.10 6 492858 89 110096346
Device malfunction 10.32 10.10 69 492795 25489 110070946
Oral dysaesthesia 10.31 10.10 9 492855 261 110096174
Acute myeloid leukaemia recurrent 10.29 10.10 5 492859 5134 110091301
Tachypnoea 10.29 10.10 239 492625 39156 110057279
Nodal arrhythmia 10.28 10.10 27 492837 2157 110094278
Cerebellar stroke 10.26 10.10 16 492848 876 110095559
Vulval cancer 10.25 10.10 13 492851 586 110095849
Thyroid mass 10.20 10.10 5 492859 5108 110091327
Disease risk factor 10.20 10.10 9 492855 265 110096170
Venoocclusive disease 10.19 10.10 8 492856 6342 110090093
Cardiac output decreased 10.17 10.10 26 492838 2043 110094392
Thinking abnormal 10.17 10.10 34 492830 15106 110081329
Duodenal ulcer haemorrhage 10.16 10.10 66 492798 7971 110088464
Aphthous ulcer 10.15 10.10 54 492810 21082 110075353
Myopathy 10.14 10.10 162 492702 24798 110071637
Hypertensive heart disease 10.13 10.10 44 492820 4552 110091883
Spinal stenosis 10.12 10.10 47 492817 19009 110077426
Bradyphrenia 10.11 10.10 88 492776 11640 110084795
Kounis syndrome 10.11 10.10 7 492857 5918 110090517
Hepatitis acute 10.11 10.10 128 492736 18638 110077797
Macroglossia 10.10 10.10 21 492843 1440 110094995

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX17 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX23 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000181 Angiotensin-converting Enzyme Inhibitors
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50664 matrix metalloproteinase inhibitor
CHEBI has role CHEBI:77307 cardioprotective agent
CHEBI has role CHEBI:77496 bradykinin receptor B<small><sub>2</sub></small> agonist
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:49103 drug metabolite

Related Drugs by ATC class:

C09AA ACE inhibitors, plain 15 drugs
benazeprilcaptoprilcilazaprildelaprilenalaprilfosinoprilimidaprillisinoprilmoexiprilperindoprilquinaprilspirapril show all 15 →
C09BA ACE inhibitors and diuretics 11 drugs
benazeprilcaptoprilcilazaprildelaprilenalaprilfosinoprillisinoprilmoexiprilperindoprilquinaprilzofenopril
C09BB ACE inhibitors and calcium channel blockers 13 drugs
amlodipinebenazeprildelaprilenalaprilfelodipinelercanidipinelisinoprilmanidipinenitrendipineperindopriltrandolaprilverapamil show all 13 →
C09BX ACE inhibitors, other combinations 7 drugs
amlodipinebisoprololhydrochlorothiazideindapamidenebivololperindoprilzofenopril
C10BX Lipid modifying agents in combination with other drugs 14 drugs
acetylsalicylic acidamlodipineatorvastatincandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilpravastatinrosuvastatinsimvastatin show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Cerebrovascular accident indication 230690007
Left ventricular cardiac dysfunction indication 429589006
Myocardial Infarction Prevention indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Acute scleroderma renal crisis off-label use 236503001
Diastolic heart failure off-label use 418304008 DOID:9775
Hypertension due to Scleroderma off-label use
Nondiabetic Proteinuric Nephropathy off-label use
Hyperkalemia contraindication 14140009
Acute vomiting contraindication 23971007
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Systemic sclerosis contraindication 89155008 DOID:418
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Hyposensitization to allergens contraindication 182678001
Disease of liver contraindication 235856003 DOID:409
Renal dialysis contraindication 265764009
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Severe diarrhea contraindication 409587002
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.21 acidic
pKa2 5.77 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG/ML VOSTALLY ROSEMONT PHARMS N219757 July 23, 2025 DISCN SOLUTION ORAL 12343338 Aug. 16, 2039 VOSTALLY IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 8.34 WOMBAT-PK CHEMBL
Angiotensin-converting enzyme Enzyme IC50 6.60 CHEMBL

External reference:

IDSource
4019562 VUID
N0000147662 NUI
D00421 KEGG_DRUG
4019562 VANDF
C0072973 UMLSCUI
CHEBI:8774 CHEBI
X92 PDB_CHEM_ID
CHEMBL1168 ChEMBL_ID
D017257 MESH_DESCRIPTOR_UI
DB00178 DRUGBANK_ID
5362129 PUBCHEM_CID
6339 IUPHAR_LIGAND_ID
5561 INN_ID
L35JN3I7SJ UNII
DB14208 DRUGBANK_ID
1546377 RXNORM
130231 MMSL
5411 MMSL
d00728 MMSL
003585 NDDF
108564000 SNOMEDCT_US
386872004 SNOMEDCT_US
C0072970 UMLSCUI
CHEMBL1201365 ChEMBL_ID
87269-97-4 SECONDARY_CAS_RN
5464096 PUBCHEM_CID
6344 IUPHAR_LIGAND_ID
5713 INN_ID
C052549 MESH_SUPPLEMENTAL_RECORD_UI
6N5U4QFC3G UNII
CHEBI:77363 CHEBI
6N5U4QFC3G INXIGHT DRUGS
L35JN3I7SJ INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0106 CAPSULE 1.25 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0107 CAPSULE 2.50 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0108 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 0054-0109 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 10544-588 CAPSULE 10 mg ORAL ANDA 27 sections
RAMIPRIL HUMAN PRESCRIPTION DRUG LABEL 1 17856-0108 CAPSULE 5 mg ORAL ANDA 25 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-821 CAPSULE 2.50 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-822 CAPSULE 5 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 21695-823 CAPSULE 10 mg ORAL ANDA 20 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-903 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 33261-967 CAPSULE 10 mg ORAL ANDA 27 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-441 CAPSULE 10 mg ORAL ANDA 28 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 45865-443 CAPSULE 5 mg ORAL ANDA 27 sections
Ramipril Human Prescription Drug Label 1 50090-1118 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-1120 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-3059 CAPSULE 2.50 mg ORAL ANDA 22 sections
Ramipril Human Prescription Drug Label 1 50090-3873 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 50090-4597 CAPSULE 5 mg ORAL ANDA 23 sections
Ramipril Human Prescription Drug Label 1 50090-5673 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-5730 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-5947 CAPSULE 2.50 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-6829 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril Human Prescription Drug Label 1 50090-7887 CAPSULE 10 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51407-707 CAPSULE 2.50 mg ORAL ANDA 29 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51407-708 CAPSULE 5 mg ORAL ANDA 29 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51407-709 CAPSULE 10 mg ORAL ANDA 29 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51655-144 CAPSULE 5 mg ORAL ANDA 22 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51655-296 CAPSULE 5 mg ORAL ANDA 26 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51655-346 CAPSULE 10 mg ORAL ANDA 22 sections
Ramipril HUMAN PRESCRIPTION DRUG LABEL 1 51655-347 CAPSULE 2.50 mg ORAL ANDA 22 sections