rosuvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 2406 287714-41-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rosuvastatin
  • rosuvastatin calcium
  • crestor
  • rosuvastatin zinc
  • ZD4522
A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.
  • Molecular weight: 481.54
  • Formula: C22H28FN3O6S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 140.92
  • ALOGS: -3.74
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.19 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
EoM (Fraction excreted unchanged in urine) 30 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.33 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,CDK5,GRK2,PDK1,PDK2,PDK4,PRKDC 7
kinase-selectivity-class GRK2 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 2.455 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.011 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 12, 2003 FDA IPR
Jan. 19, 2005 PMDA AstraZeneca K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 1947.68 9.40 1390 245385 49866 90331806
Myalgia 1705.40 9.40 2238 244537 172887 90208785
Pemphigus 815.34 9.40 15 246760 326849 90054823
Maternal exposure during pregnancy 804.76 9.40 43 246732 360020 90021652
Systemic lupus erythematosus 713.80 9.40 77 246698 361819 90019853
Glossodynia 693.08 9.40 47 246728 321732 90059940
Hand deformity 647.99 9.40 40 246735 296322 90085350
Anti-cyclic citrullinated peptide antibody positive 620.30 9.40 4 246771 236429 90145243
Blood creatine phosphokinase increased 606.61 9.40 596 246179 33427 90348245
Wound 576.12 9.40 73 246702 302907 90078765
Duodenal ulcer perforation 569.62 9.40 6 246769 221282 90160390
Synovitis 529.62 9.40 124 246651 329628 90052044
Folliculitis 491.48 9.40 14 246761 204339 90177333
Pericarditis 487.97 9.40 76 246699 270075 90111597
Creatinine renal clearance decreased 467.87 9.40 398 246377 18501 90363171
Helicobacter infection 466.16 9.40 41 246734 226809 90154863
Acute kidney injury 444.09 9.40 1888 244887 318499 90063173
Sedation complication 434.20 9.40 364 246411 16580 90365092
Treatment failure 429.22 9.40 146 246629 303782 90077890
Contraindicated product administered 426.46 9.40 169 246606 319970 90061702
Exposure during pregnancy 426.19 9.40 69 246706 238341 90143331
Impaired healing 422.67 9.40 66 246709 234133 90147539
Orthostatic hypotension 411.56 9.40 538 246237 41289 90340383
Rheumatic fever 394.70 9.40 4 246771 153117 90228555
Arthropathy 383.47 9.40 264 246511 365978 90015694
Cognitive disorder 368.67 9.40 671 246104 68736 90312936
Infusion related reaction 368.54 9.40 355 246420 416425 89965247
Muscle injury 368.19 9.40 30 246745 176624 90205048
Asthma 352.48 9.40 1449 245326 240711 90140961
Blood calcium decreased 350.83 9.40 422 246353 29760 90351912
Irritable bowel syndrome 347.11 9.40 71 246704 207377 90174295
Blood pressure increased 313.34 9.40 1213 245562 196004 90185668
Angina pectoris 309.15 9.40 453 246322 38707 90342965
Cough 304.90 9.40 1881 244894 367081 90014591
Balance disorder 304.29 9.40 757 246018 96323 90285349
Blister 301.55 9.40 159 246616 254839 90126833
Sleep disorder due to general medical condition, insomnia type 294.83 9.40 13 246762 128681 90252991
Myopathy 291.08 9.40 263 246512 13255 90368417
Therapeutic product effect decreased 278.76 9.40 209 246566 277362 90104310
Injury 278.15 9.40 95 246680 197254 90184418
Nasal oedema 267.11 9.40 186 246589 6398 90375274
Swelling 257.78 9.40 467 246308 418591 89963081
Fall 250.32 9.40 2199 244576 479611 89902061
Facet joint syndrome 247.23 9.40 4 246771 98385 90283287
Stomatitis 244.94 9.40 232 246543 274466 90107206
Respiratory tract infection 241.89 9.40 512 246263 58566 90323106
Low density lipoprotein increased 239.43 9.40 189 246586 7896 90373776
Sedation 237.36 9.40 451 246324 47720 90333952
Blood glucose increased 237.11 9.40 682 246093 94564 90287108
Rheumatoid factor positive 236.10 9.40 86 246689 171564 90210108
Infection 235.90 9.40 389 246386 361705 90019967
Fibromyalgia 226.14 9.40 141 246634 206128 90175544
General physical health deterioration 223.51 9.40 390 246385 354725 90026947
Product use issue 222.84 9.40 346 246429 329573 90052099
Lip dry 222.36 9.40 13 246762 100942 90280730
Constipation 218.06 9.40 1408 245367 278987 90102685
Discomfort 217.34 9.40 256 246519 274079 90107593
Hepatic enzyme increased 202.68 9.40 424 246351 360312 90021360
Drug ineffective 199.83 9.40 2618 244157 1381680 88999992
Live birth 199.67 9.40 3 246772 79104 90302568
Alopecia 199.52 9.40 686 246089 494385 89887287
Grip strength decreased 197.72 9.40 14 246761 92562 90289110
Abdominal discomfort 187.91 9.40 668 246107 476660 89905012
Arterial occlusive disease 185.45 9.40 198 246577 12248 90369424
Off label use 183.48 9.40 2020 244755 1100232 89281440
Drug interaction 182.17 9.40 1333 245442 275120 90106552
Hypotension 180.75 9.40 1508 245267 323889 90057783
Joint range of motion decreased 176.56 9.40 74 246701 135569 90246103
Ill-defined disorder 175.74 9.40 147 246628 184744 90196928
Hypersensitivity 175.17 9.40 642 246133 454035 89927637
Depressed level of consciousness 173.29 9.40 513 246262 72271 90309401
Psoriatic arthropathy 172.47 9.40 221 246554 228114 90153558
Gangrene 166.20 9.40 190 246585 12686 90368986
Drug intolerance 165.91 9.40 642 246133 446949 89934723
Peripheral venous disease 162.34 9.40 19 246756 83902 90297770
Blood pressure systolic increased 161.18 9.40 434 246341 57911 90323761
Immune-mediated myositis 159.75 9.40 93 246682 2328 90379344
Dyslipidaemia 158.08 9.40 165 246610 9942 90371730
Carotid artery thrombosis 157.79 9.40 157 246618 8935 90372737
Wound infection 157.36 9.40 47 246728 106355 90275317
Neurologic neglect syndrome 152.12 9.40 152 246623 8695 90372977
Cataract 146.55 9.40 481 246294 71611 90310061
Euglycaemic diabetic ketoacidosis 146.17 9.40 127 246648 6074 90375598
Skin haemorrhage 144.28 9.40 230 246545 21150 90360522
Sinus congestion 144.13 9.40 264 246511 27160 90354512
Pregnancy 142.98 9.40 6 246769 62041 90319631
Prescribed overdose 142.79 9.40 44 246731 97581 90284091
Cystitis 142.73 9.40 453 246322 66265 90315407
Adjustment disorder 141.21 9.40 152 246623 9490 90372182
Night sweats 137.01 9.40 91 246684 128675 90252997
Bursitis 136.14 9.40 96 246679 131558 90250114
Lactic acidosis 134.02 9.40 370 246405 50093 90331579
Lower respiratory tract infection 130.53 9.40 307 246468 250352 90131320
Affect lability 128.38 9.40 199 246576 17864 90363808
High density lipoprotein decreased 126.93 9.40 83 246692 2568 90379104
Joint swelling 126.85 9.40 826 245949 502474 89879198
Multi-organ disorder 123.08 9.40 76 246699 2124 90379548
Autoimmune disorder 122.76 9.40 29 246746 76715 90304957
Blood triglycerides increased 121.58 9.40 168 246607 13593 90368079
Intentional product use issue 119.98 9.40 257 246518 216635 90165037
Blepharospasm 119.51 9.40 8 246767 55437 90326235
Liver injury 118.80 9.40 175 246600 170392 90211280
Obstructive airways disorder 118.63 9.40 235 246540 25634 90356038
Cerebrovascular accident 118.08 9.40 655 246120 122878 90258794
Hemiplegia 116.20 9.40 179 246596 15981 90365691
Sensory loss 115.91 9.40 190 246585 17885 90363787
Dyspnoea 115.69 9.40 3177 243598 877778 89503894
Palpitations 115.12 9.40 701 246074 136027 90245645
Myocardial infarction 113.65 9.40 580 246195 105392 90276280
Personality disorder 113.07 9.40 154 246621 12290 90369382
Renal failure 111.14 9.40 673 246102 130334 90251338
Obesity 107.68 9.40 78 246697 105429 90276243
Hip arthroplasty 106.77 9.40 37 246738 76171 90305501
Blood creatinine increased 106.01 9.40 551 246224 100835 90280837
X-ray abnormal 105.99 9.40 4 246771 45420 90336252
Muscle spasms 105.84 9.40 1100 245675 250783 90130889
Pneumonia 103.79 9.40 2369 244406 635690 89745982
Lower limb fracture 103.40 9.40 51 246724 84962 90296710
Vital capacity decreased 102.18 9.40 63 246712 1756 90379916
Reversible airways obstruction 102.13 9.40 65 246710 1918 90379754
Onychomadesis 101.05 9.40 6 246769 45992 90335680
Condition aggravated 100.80 9.40 1086 245689 594459 89787213
Road traffic accident 100.49 9.40 87 246688 107539 90274133
Full blood count abnormal 99.83 9.40 271 246504 36326 90345346
Asthenia 99.70 9.40 2022 244753 531729 89849943
C-reactive protein abnormal 99.67 9.40 120 246655 127309 90254363
Nail disorder 93.14 9.40 23 246752 59044 90322628
Blood immunoglobulin E increased 93.12 9.40 85 246690 4340 90377332
Sinus disorder 92.89 9.40 254 246521 34193 90347479
Respiratory tract congestion 92.50 9.40 220 246555 27190 90354482
Completed suicide 92.33 9.40 158 246617 144900 90236772
Motor dysfunction 92.20 9.40 178 246597 19052 90362620
Diabetic ketoacidosis 90.17 9.40 203 246572 24204 90357468
Sputum culture positive 89.88 9.40 63 246712 2190 90379482
Rash 89.39 9.40 1578 245197 794522 89587150
Epilepsy 88.93 9.40 57 246718 82149 90299523
Chest discomfort 88.63 9.40 663 246112 137702 90243970
Urticaria 88.27 9.40 495 246280 312239 90069433
Inflammation 88.02 9.40 225 246550 178367 90203305
Chronic kidney disease 87.29 9.40 318 246457 49873 90331799
Thyroid disorder 86.96 9.40 166 246609 17619 90364053
Therapeutic product effect incomplete 86.81 9.40 256 246519 193640 90188032
Sneezing 86.35 9.40 226 246549 29643 90352029
Adverse event 86.20 9.40 116 246659 117302 90264370
Diabetes mellitus 85.53 9.40 377 246398 64498 90317174
Abortion spontaneous 85.33 9.40 21 246754 54035 90327637
Skin exfoliation 85.28 9.40 389 246386 67524 90314148
Hypercholesterolaemia 84.36 9.40 90 246685 100802 90280870
Eating disorder 83.82 9.40 215 246560 27858 90353814
Breast cancer stage II 82.83 9.40 3 246772 35331 90346341
Foetal exposure during pregnancy 82.44 9.40 10 246765 42965 90338707
Disease progression 82.15 9.40 191 246584 156424 90225248
Rhinorrhoea 81.55 9.40 464 246311 87852 90293820
Pulmonary mass 80.43 9.40 215 246560 28557 90353115
Hemiparesis 80.26 9.40 229 246546 31590 90350082
Aphasia 79.37 9.40 277 246498 42535 90339137
Onychomycosis 78.81 9.40 6 246769 37370 90344302
Alanine aminotransferase increased 78.04 9.40 571 246204 117767 90263905
COVID-19 77.95 9.40 752 246023 168091 90213581
Device expulsion 77.25 9.40 10 246765 40876 90340796
Therapy non-responder 77.23 9.40 160 246615 136544 90245128
Bronchiectasis 76.19 9.40 180 246595 22150 90359522
Glycosylated haemoglobin increased 75.77 9.40 145 246630 15417 90366255
Coeliac disease 75.12 9.40 15 246760 44595 90337077
Oedema 73.65 9.40 852 245923 199443 90182229
Ischaemic stroke 72.74 9.40 176 246599 21990 90359682
Hypoglycaemia 72.59 9.40 379 246396 69469 90312203
Coronary artery disease 72.54 9.40 229 246546 33394 90348278
Malaise 72.14 9.40 2097 244678 583889 89797783
Coordination abnormal 71.62 9.40 171 246604 21185 90360487
Death 71.48 9.40 847 245928 455704 89925968
Pain in extremity 71.34 9.40 1667 245108 448862 89932810
Transaminases increased 71 9.40 243 246532 36949 90344723
Chest pain 70.61 9.40 1243 245532 318402 90063270
Type 2 diabetes mellitus 70.47 9.40 299 246476 202945 90178727
Gait inability 70.26 9.40 187 246588 146269 90235403
Hyperglycaemia 70.09 9.40 300 246475 50670 90331002
Lung disorder 69.94 9.40 194 246581 149689 90231983
Injection site reaction 69.60 9.40 89 246686 91991 90289681
Psoriasis 68.65 9.40 659 246116 147095 90234577
Human rhinovirus test positive 68.50 9.40 38 246737 865 90380807
Drug tolerance decreased 68.19 9.40 5 246770 32125 90349547
Influenza 68.13 9.40 628 246147 138636 90243036
Respiratory syncytial virus test positive 68.12 9.40 40 246735 1018 90380654
Eye haemorrhage 66.61 9.40 108 246667 10072 90371600
Muscular weakness 66.39 9.40 857 245918 205809 90175863
Lupus-like syndrome 66.24 9.40 25 246750 48821 90332851
Bronchial secretion retention 65.66 9.40 64 246711 3551 90378121
Premature delivery 65.34 9.40 13 246762 38749 90342923
Vertigo 65.25 9.40 368 246407 69443 90312229
Malignant mediastinal neoplasm 64.78 9.40 43 246732 1365 90380307
Tubulointerstitial nephritis 63.54 9.40 182 246593 25161 90356511
Renal impairment 62.96 9.40 497 246278 104924 90276748
Atrial fibrillation 62.11 9.40 596 246179 133015 90248657
Influenza like illness 62.04 9.40 404 246371 80207 90301465
Eosinophil count increased 61.39 9.40 120 246655 12961 90368711
Total lung capacity decreased 61.23 9.40 63 246712 3732 90377940
Crush syndrome 60.63 9.40 25 246750 284 90381388
Nephritic syndrome 60.32 9.40 27 246748 380 90381292
Low density lipoprotein decreased 59.97 9.40 24 246751 251 90381421
Angina unstable 59.82 9.40 85 246690 7058 90374614
Hepatic cirrhosis 59.20 9.40 51 246724 63202 90318470
Myoglobin blood increased 58.68 9.40 42 246733 1510 90380162
Arthritis 58.52 9.40 705 246070 166610 90215062
Musculoskeletal stiffness 58.35 9.40 521 246254 296011 90085661
Prescribed underdose 57.23 9.40 72 246703 74947 90306725
Blood calcium increased 57.05 9.40 111 246664 11947 90369725
Blood test abnormal 55.00 9.40 153 246622 20799 90360873
Hyper IgE syndrome 54.76 9.40 27 246748 478 90381194
Viral test positive 54.16 9.40 29 246746 614 90381058
Pulmonary fibrosis 54.07 9.40 134 246641 107369 90274303
Back injury 53.69 9.40 30 246745 46592 90335080
Exostosis 53.28 9.40 40 246735 53094 90328578
Pneumonia haemophilus 53.02 9.40 39 246736 1464 90380208
Product substitution issue 52.81 9.40 137 246638 17871 90363801
Bronchopulmonary aspergillosis allergic 52.76 9.40 58 246717 3708 90377964
Myopathy toxic 52.58 9.40 28 246747 586 90381086
Degenerative bone disease 52.14 9.40 22 246753 266 90381406
Glomerular filtration rate decreased 51.92 9.40 131 246644 16801 90364871
Blood pressure fluctuation 51.46 9.40 280 246495 52133 90329539
Restrictive pulmonary disease 50.94 9.40 46 246729 2316 90379356
Weight decreased 50.70 9.40 1374 245401 378536 90003136
Diabetes mellitus inadequate control 50.60 9.40 138 246637 18546 90363126
Product use in unapproved indication 50.59 9.40 629 246146 335607 90046065
Sciatica 50.50 9.40 127 246648 101255 90280417
Sleep disorder 50.28 9.40 324 246451 197706 90183966
Vitamin B12 decreased 50.20 9.40 67 246708 5243 90376429
Hepatocellular injury 49.95 9.40 183 246592 28775 90352897
Hypoaesthesia 49.48 9.40 582 246193 313628 90068044
Coronary artery stenosis 49.11 9.40 66 246709 5200 90376472
Dermatitis allergic 48.96 9.40 130 246645 17197 90364475
Transient ischaemic attack 48.87 9.40 240 246535 42936 90338736
Adverse drug reaction 48.73 9.40 159 246616 116542 90265130
Normal newborn 48.55 9.40 4 246771 23358 90358314
Creatinine renal clearance increased 48.53 9.40 52 246723 3229 90378443
Coronary artery occlusion 48.34 9.40 85 246690 8469 90373203
Knee arthroplasty 48.13 9.40 96 246679 83086 90298586
Lipids increased 47.97 9.40 35 246740 1297 90380375
Drug ineffective for unapproved indication 47.74 9.40 67 246708 66577 90315095
Body temperature decreased 47.57 9.40 158 246617 23658 90358014
Blood pressure diastolic decreased 47.52 9.40 171 246604 26655 90355017
Hyperkalaemia 47.22 9.40 321 246454 64643 90317029
Taste disorder 47.02 9.40 59 246716 61487 90320185
Neutropenia 46.97 9.40 389 246386 224515 90157157
Aspartate aminotransferase increased 46.76 9.40 457 246318 102480 90279192
Foetal acidosis 45.92 9.40 11 246764 12 90381660
Thrombocytopenia 45.90 9.40 356 246419 208369 90173303
Paroxysmal extreme pain disorder 45.82 9.40 16 246759 110 90381562
Dysarthria 45.61 9.40 279 246496 54203 90327469
Rales 44.98 9.40 119 246656 15708 90365964
Cerebral infarction 44.97 9.40 167 246608 26429 90355243
Chromaturia 44.47 9.40 134 246641 19053 90362619
Lung opacity 44.45 9.40 68 246707 6034 90375638
Blood pressure systolic abnormal 44.18 9.40 135 246640 19343 90362329
Joint dislocation 44.14 9.40 34 246741 44548 90337124
Pancreatic neuroendocrine tumour 43.99 9.40 25 246750 597 90381075
Mouth haemorrhage 43.61 9.40 81 246694 8420 90373252
Upper-airway cough syndrome 43.22 9.40 114 246661 15021 90366651
Dry skin 42.98 9.40 397 246378 87676 90293996
Multiple allergies 42.15 9.40 113 246662 15033 90366639
Pyrexia 42.06 9.40 1425 245350 659060 89722612
Wheezing 42.04 9.40 895 245880 237185 90144487
Blood cholesterol increased 41.99 9.40 363 246412 207649 90174023
Contusion 40.83 9.40 462 246313 250754 90130918
Acute myocardial infarction 40.25 9.40 195 246580 34695 90346977
Diverticulitis 40.13 9.40 235 246540 44952 90336720
Post procedural hypothyroidism 40.12 9.40 20 246755 363 90381309
Polymyalgia rheumatica 39.88 9.40 58 246717 4919 90376753
Injection site scab 39.47 9.40 24 246751 652 90381020
Burning sensation 39.46 9.40 302 246473 63150 90318522
Laryngitis 39.45 9.40 48 246727 50705 90330967
Gastrointestinal disorder 39.04 9.40 479 246296 256208 90125464
Renal function test abnormal 38.76 9.40 70 246705 7121 90374551
Lichen planopilaris 38.63 9.40 16 246759 184 90381488
Muscle discomfort 38.43 9.40 18 246757 283 90381389
Chronic respiratory disease 38.43 9.40 18 246757 283 90381389
Back pain 38.36 9.40 1133 245642 316042 90065630
Ulnar tunnel syndrome 37.97 9.40 9 246766 9 90381663
Dyspnoea exertional 37.91 9.40 331 246444 71957 90309715
Sputum discoloured 37.85 9.40 132 246643 20259 90361413
Intentional overdose 37.69 9.40 130 246645 93704 90287968
Musculoskeletal toxicity 37.32 9.40 22 246753 564 90381108
Foetal death 36.99 9.40 6 246769 20717 90360955
Coma 36.94 9.40 90 246685 72542 90309130
C-reactive protein increased 36.85 9.40 316 246459 181073 90200599
Intentional self-injury 36.58 9.40 17 246758 29317 90352355
Delirium 36.47 9.40 153 246622 104206 90277466
Colitis microscopic 35.97 9.40 88 246687 11071 90370601
Head discomfort 35.93 9.40 112 246663 16221 90365451
Adverse reaction 35.86 9.40 18 246757 29694 90351978
Blood pressure abnormal 35.45 9.40 126 246649 19519 90362153
Blood pressure diastolic abnormal 35.44 9.40 127 246648 19754 90361918
Confusional arousal 34.94 9.40 17 246758 292 90381380
Pancytopenia 34.62 9.40 189 246586 120074 90261598
Product quality issue 34.57 9.40 106 246669 79219 90302453
Finger deformity 33.98 9.40 24 246751 32873 90348799
Tongue biting 33.67 9.40 35 246740 2098 90379574
Heart rate increased 33.66 9.40 462 246313 112440 90269232
Myelosuppression 33.51 9.40 59 246716 53532 90328140
Productive cough 33.48 9.40 339 246436 76724 90304948
Dehydration 33.37 9.40 728 246047 193719 90187953
Arteriosclerosis 33.31 9.40 84 246691 10769 90370903
Leukopenia 33.16 9.40 151 246624 100559 90281113
Blood glucose abnormal 32.91 9.40 77 246698 9415 90372257
Hernia 32.62 9.40 99 246676 14132 90367540
Vomiting 32.52 9.40 2529 244246 785764 89595908
Device dislocation 32.47 9.40 23 246752 31459 90350213
Cardiac failure 32.21 9.40 447 246328 109049 90272623
Weight increased 32.14 9.40 879 245896 417048 89964624
Pancreatitis acute 31.81 9.40 172 246603 31943 90349729
Caesarean section 31.80 9.40 6 246769 18571 90363101
Macular degeneration 31.59 9.40 34 246741 37936 90343736
Confabulation 31.44 9.40 16 246759 304 90381368
Oropharyngeal pain 31.40 9.40 464 246311 114723 90266949
Amblyopia 31.34 9.40 16 246759 306 90381366
Polymyositis 31.29 9.40 34 246741 2145 90379527
Peripheral sensorimotor neuropathy 31.29 9.40 33 246742 2012 90379660
Dyspepsia 31.19 9.40 367 246408 197793 90183879
Confusional state 30.81 9.40 808 245967 385397 89996275
Metabolic acidosis 30.80 9.40 258 246517 55418 90326254
Cytomegalovirus infection 30.80 9.40 17 246758 26585 90355087
Listless 30.72 9.40 41 246734 3208 90378464
Therapy partial responder 30.36 9.40 11 246764 22032 90359640
Eye irritation 30.36 9.40 177 246598 33801 90347871
C3 glomerulopathy 30.32 9.40 13 246762 164 90381508
Muscle rupture 30.26 9.40 40 246735 3101 90378571
Red blood cell sedimentation rate increased 30.18 9.40 119 246656 82476 90299196
Nephrolithiasis 30.17 9.40 233 246542 48852 90332820
HIV infection 30.14 9.40 18 246757 473 90381199
Hyperlipidaemia 30.06 9.40 133 246642 22783 90358889
Hepatic enzyme abnormal 29.85 9.40 65 246710 7577 90374095
Drug-disease interaction 29.84 9.40 23 246752 927 90380745
Hepatic function abnormal 29.73 9.40 222 246553 46066 90335606
Dysphagia 29.72 9.40 450 246325 111828 90269844
Toxic epidermal necrolysis 29.50 9.40 27 246748 32501 90349171
Respiratory disorder 29.41 9.40 85 246690 64731 90316941
Walking aid user 29.31 9.40 32 246743 35474 90346198
Nightmare 29.20 9.40 127 246648 21598 90360074
Seizure 29.19 9.40 270 246505 152359 90229313
General symptom 29.18 9.40 3 246772 14665 90367007
Hypomagnesaemia 29.00 9.40 181 246594 35407 90346265
Androgenetic alopecia 28.85 9.40 13 246762 186 90381486
Haemorrhagic diathesis 28.80 9.40 53 246722 5471 90376201
Acute coronary syndrome 28.42 9.40 79 246696 10734 90370938
Goitre 28.09 9.40 59 246716 6708 90374964
Necrotising myositis 28.05 9.40 21 246754 810 90380862
Muscle disorder 27.85 9.40 52 246723 5427 90376245
Pemphigoid 27.85 9.40 70 246705 8956 90372716
Multiple drug therapy 27.82 9.40 60 246715 6949 90374723
Microalbuminuria 27.81 9.40 18 246757 547 90381125
Dizziness 27.40 9.40 1909 244866 587375 89794297
Eye pain 27.34 9.40 210 246565 43958 90337714
Infusion site reaction 27.09 9.40 9 246766 19030 90362642
Blood pressure decreased 26.79 9.40 317 246458 74578 90307094
Giant cell arteritis 26.79 9.40 37 246738 2992 90378680
Stress 26.73 9.40 339 246436 81056 90300616
Needle issue 26.56 9.40 91 246684 13843 90367829
Temperature regulation disorder 26.52 9.40 4 246771 14575 90367097
Skin discolouration 26.49 9.40 209 246566 44106 90337566
Ear infection 26.48 9.40 99 246676 69676 90311996
Pertussis 26.42 9.40 21 246754 886 90380786
Subcutaneous drug absorption impaired 26.36 9.40 3 246772 13542 90368130
Premature baby 26.29 9.40 18 246757 25059 90356613
Female genital tract fistula 26.21 9.40 8 246767 17860 90363812
Malnutrition 26.11 9.40 110 246665 18448 90363224
Gamma-glutamyltransferase increased 26.08 9.40 185 246590 37767 90343905
Peripheral swelling 26.07 9.40 892 245883 412214 89969458
Proteinuria 26.02 9.40 129 246646 23162 90358510
Lipids abnormal 25.75 9.40 14 246761 306 90381366
Pollakiuria 25.74 9.40 166 246609 32839 90348833
Dysgeusia 25.68 9.40 237 246538 52323 90329349
Drug abuse 25.62 9.40 126 246649 82221 90299451
Dermatitis artefacta 25.51 9.40 9 246766 64 90381608
Hepatic steatosis 25.34 9.40 180 246595 36765 90344907
Endocrine ophthalmopathy 25.32 9.40 22 246753 1052 90380620
Seronegative arthritis 25.28 9.40 9 246766 18225 90363447
Underdose 25.12 9.40 70 246705 53947 90327725
Generalised tonic-clonic seizure 25.08 9.40 35 246740 34868 90346804
Chronic sinusitis 25.07 9.40 17 246758 23785 90357887
Heart rate decreased 25.01 9.40 239 246536 53266 90328406
Middle insomnia 24.91 9.40 101 246674 16650 90365022
Poisoning deliberate 24.89 9.40 7 246768 16479 90365193
Rheumatic disorder 24.85 9.40 38 246737 3370 90378302
Suicide attempt 24.85 9.40 113 246662 75286 90306386
Muscle atrophy 24.72 9.40 64 246711 8337 90373335
Clostridium test positive 24.68 9.40 49 246726 5352 90376320
Flatulence 24.67 9.40 195 246580 41172 90340500
Muscle hypoxia 24.54 9.40 5 246770 0 90381672
Autoimmune myositis 24.46 9.40 14 246761 339 90381333
Blood immunoglobulin M increased 24.38 9.40 24 246751 1348 90380324
Anuria 24.18 9.40 92 246683 14726 90366946
Panniculitis 24.05 9.40 5 246770 14453 90367219
Eye pruritus 23.89 9.40 148 246627 28879 90352793
Febrile neutropenia 23.87 9.40 296 246479 158053 90223619
Reduced facial expression 23.81 9.40 32 246743 2521 90379151
Hyperkeratosis 23.80 9.40 56 246719 6872 90374800
Lung diffusion test decreased 23.69 9.40 19 246756 812 90380860
Urinary retention 23.66 9.40 180 246595 37564 90344108
Blood cholesterol abnormal 23.63 9.40 34 246741 2856 90378816
Nasal congestion 23.52 9.40 338 246437 83076 90298596
Sinusitis 23.50 9.40 733 246042 342355 90039317
Eye disorder 23.39 9.40 141 246634 27249 90354423
Interstitial lung disease 23.32 9.40 314 246461 76091 90305581
Creutzfeldt-Jakob disease 23.26 9.40 11 246764 177 90381495
Blood urea increased 23.13 9.40 152 246623 30261 90351411
Immobilisation syndrome 23.11 9.40 15 246760 458 90381214
Degenerative aortic valve disease 23.03 9.40 11 246764 181 90381491
Tremor 22.73 9.40 562 246213 152611 90229061
Mononeuropathy multiplex 22.71 9.40 14 246761 390 90381282
Eyelid disorder 22.70 9.40 29 246746 2174 90379498
Pancreatitis 22.58 9.40 290 246485 69536 90312136
Blood creatine increased 22.52 9.40 55 246720 6912 90374760
Sputum culture 22.49 9.40 13 246762 321 90381351
Cerebral haemorrhage 22.41 9.40 166 246609 34356 90347316
Alopecia scarring 22.40 9.40 11 246764 193 90381479
Transcription medication error 22.37 9.40 12 246763 255 90381417
Hyperhidrosis 22.32 9.40 507 246268 135798 90245874
Immobile 22.29 9.40 52 246723 6346 90375326
Blood pressure inadequately controlled 22.14 9.40 51 246724 6173 90375499
Blood albumin abnormal 22.11 9.40 21 246754 1128 90380544
Transplant rejection 22.10 9.40 4 246771 12754 90368918
Parosmia 22.00 9.40 55 246720 7014 90374658
Lipoprotein (a) increased 21.98 9.40 8 246767 63 90381609
Myocardial ischaemia 21.92 9.40 85 246690 13729 90367943
Tongue discomfort 21.83 9.40 32 246743 2733 90378939
Chest wall mass 21.76 9.40 16 246759 600 90381072
Hypereosinophilic syndrome 21.58 9.40 13 246762 347 90381325
Occult blood 21.58 9.40 22 246753 1289 90380383
Lipase increased 21.56 9.40 73 246702 11038 90370634
Albuminuria 21.55 9.40 13 246762 348 90381324
Blood immunoglobulin G increased 21.48 9.40 33 246742 2939 90378733
International normalised ratio increased 21.45 9.40 210 246565 47106 90334566
Thrombotic microangiopathy 21.44 9.40 8 246767 15735 90365937
Drug tolerance 21.40 9.40 11 246764 17905 90363767
Drug hypersensitivity 21.37 9.40 1501 245274 462108 89919564
Scan abnormal 21.29 9.40 16 246759 621 90381051
Discontinued product administered 21.24 9.40 9 246766 110 90381562
Radiculopathy 21.17 9.40 12 246763 18493 90363179
Cardiac failure congestive 21.11 9.40 382 246393 98312 90283360
Diffuse alopecia 21.05 9.40 21 246754 1199 90380473
Asthmatic crisis 21.04 9.40 26 246749 1884 90379788
Metastases to bone 21.04 9.40 23 246752 25482 90356190
Amylase increased 20.94 9.40 54 246721 7018 90374654
Osteoarthritis 20.89 9.40 391 246384 195339 90186333
Tension headache 20.87 9.40 56 246719 7453 90374219
Skin necrosis 20.84 9.40 10 246765 16931 90364741
Blood parathyroid hormone decreased 20.79 9.40 4 246771 12212 90369460
Disease risk factor 20.67 9.40 11 246764 230 90381442
Feeling abnormal 20.63 9.40 599 246176 166636 90215036
Pericardial effusion 20.54 9.40 171 246604 36662 90345010
Rash vesicular 20.54 9.40 12 246763 18185 90363487
Rheumatoid nodule 20.45 9.40 15 246760 20151 90361521
Muscle contractions involuntary 20.45 9.40 32 246743 2896 90378776
Akathisia 20.44 9.40 3 246772 11156 90370516
Food interaction 20.42 9.40 21 246754 1243 90380429
Chronic spontaneous urticaria 20.42 9.40 25 246750 1795 90379877
Neutropenic sepsis 20.40 9.40 12 246763 18118 90363554
Tinnitus 20.38 9.40 193 246582 42909 90338763
Vaginal discharge 20.37 9.40 14 246761 19450 90362222
Ulcer haemorrhage 20.35 9.40 25 246750 26296 90355376
Sleep apnoea syndrome 20.24 9.40 152 246623 31595 90350077
Erythema multiforme 19.96 9.40 76 246699 12170 90369502
Toxic shock syndrome 19.94 9.40 19 246756 1025 90380647
Endometriosis 19.85 9.40 49 246726 6199 90375473
Forced vital capacity decreased 19.81 9.40 20 246755 1158 90380514
Sinonasal obstruction 19.77 9.40 11 246764 252 90381420
Incorrect route of product administration 19.75 9.40 71 246704 50555 90331117
Swelling of eyelid 19.74 9.40 45 246730 5409 90376263
Micturition disorder 19.71 9.40 32 246743 2988 90378684
Mast cell activation syndrome 19.69 9.40 23 246752 1571 90380101
Spondylitis 19.66 9.40 7 246768 14171 90367501
Amyloid related imaging abnormality-oedema/effusion 19.60 9.40 18 246757 926 90380746
Respiratory rate increased 19.60 9.40 91 246684 15910 90365762
Joint destruction 19.40 9.40 6 246769 13281 90368391
Immunodeficiency 19.39 9.40 57 246718 43177 90338495
Inappropriate schedule of product administration 19.32 9.40 540 246235 149393 90232279
Procollagen type I C-terminal propeptide increased 19.30 9.40 6 246769 27 90381645
Medication error 19.25 9.40 143 246632 84509 90297163
Catarrh 19.23 9.40 23 246752 1611 90380061
Mucosal inflammation 19.21 9.40 86 246689 57539 90324133
Muscle spasticity 19.18 9.40 163 246612 35159 90346513
Serum procollagen type I N-terminal propeptide increased 19.12 9.40 6 246769 28 90381644
Blood alkaline phosphatase abnormal 19.04 9.40 21 246754 1347 90380325
Gestational diabetes 19.03 9.40 3 246772 10579 90371093
Respiratory arrest 18.79 9.40 39 246736 33272 90348400
Proctitis 18.78 9.40 9 246766 15250 90366422
Burns second degree 18.74 9.40 25 246750 1955 90379717
Urine albumin/creatinine ratio increased 18.61 9.40 14 246761 544 90381128
Pustular psoriasis 18.56 9.40 14 246761 18542 90363130
Foreign body 18.46 9.40 28 246747 2466 90379206
Spinal flattening 18.45 9.40 11 246764 288 90381384
Vitamin D decreased 18.43 9.40 73 246702 11906 90369766
Carotid artery occlusion 18.34 9.40 48 246727 6294 90375378
Dry mouth 18.33 9.40 372 246403 183687 90197985
Hyperlactacidaemia 18.27 9.40 37 246738 4099 90377573
Ulcer 18.13 9.40 39 246736 32843 90348829
Urinary casts present 18.11 9.40 8 246767 109 90381563
Liver function test abnormal 18.09 9.40 215 246560 50630 90331042
Disability 18.07 9.40 54 246721 40691 90340981
Lacrimation increased 18.07 9.40 131 246644 26931 90354741
Infected dermal cyst 18.00 9.40 13 246762 474 90381198
Infusion site streaking 17.98 9.40 14 246761 573 90381099
Respiratory depression 17.96 9.40 10 246765 15565 90366107
Status epilepticus 17.92 9.40 15 246760 18859 90362813
Acquired apparent mineralocorticoid excess 17.91 9.40 5 246770 14 90381658
Stent placement 17.86 9.40 37 246738 4166 90377506
Blood alkaline phosphatase increased 17.86 9.40 205 246570 47874 90333798
Tongue injury 17.77 9.40 14 246761 583 90381089
Sepsis 17.74 9.40 364 246411 179450 90202222
Herpes zoster 17.74 9.40 359 246416 94285 90287387
Haemophagocytic lymphohistiocytosis 17.72 9.40 10 246765 15449 90366223
Burning feet syndrome 17.54 9.40 8 246767 118 90381554
Restless legs syndrome 17.52 9.40 113 246662 22357 90359315
Low density lipoprotein abnormal 17.51 9.40 11 246764 317 90381355
Ischaemic hepatitis 17.42 9.40 29 246746 2764 90378908
Device related infection 17.41 9.40 27 246748 25759 90355913
Allergy to animal 17.40 9.40 22 246753 1632 90380040
Myositis 17.40 9.40 119 246656 24009 90357663
Blood creatine phosphokinase abnormal 17.39 9.40 11 246764 321 90381351
Infrequent bowel movements 17.31 9.40 21 246754 1493 90380179
Total cholesterol/HDL ratio abnormal 17.18 9.40 7 246768 77 90381595
Blood glucose decreased 17.16 9.40 116 246659 23313 90358359
Urine viscosity increased 17.09 9.40 6 246769 42 90381630
Aortic disorder 17.09 9.40 16 246759 844 90380828
Rotator cuff syndrome 16.96 9.40 87 246688 15832 90365840
Injection site hypersensitivity 16.90 9.40 28 246747 2659 90379013
Renal pain 16.88 9.40 53 246722 7706 90373966
Multiple sclerosis relapse 16.87 9.40 79 246696 52226 90329446
Ketoacidosis 16.85 9.40 43 246732 5552 90376120
Sinus pain 16.84 9.40 42 246733 5347 90376325
Enamel anomaly 16.75 9.40 5 246770 19 90381653
Photosensitivity reaction 16.72 9.40 94 246681 17713 90363959
Intensive care unit acquired weakness 16.70 9.40 17 246758 994 90380678
Urinary tract infection 16.68 9.40 1004 245771 304628 90077044
Cardiac disorder 16.65 9.40 232 246543 56640 90325032
Disseminated cryptococcosis 16.63 9.40 15 246760 754 90380918
Urine ketone body present 16.60 9.40 27 246748 2525 90379147
Ageusia 16.54 9.40 87 246688 15989 90365683
Overdose 16.53 9.40 316 246459 157393 90224279
Hypopnoea 16.53 9.40 37 246738 4394 90377278
Maternal exposure before pregnancy 16.49 9.40 5 246770 11208 90370464
Depressed mood 16.41 9.40 209 246566 50013 90331659
Cardiac murmur 16.40 9.40 95 246680 18099 90363573
Lip swelling 16.36 9.40 169 246606 38441 90343231
Blood immunoglobulin A decreased 16.36 9.40 22 246753 1734 90379938
Apolipoprotein A-I decreased 16.36 9.40 5 246770 21 90381651
Low birth weight baby 16.33 9.40 3 246772 9464 90372208
Bone marrow failure 16.32 9.40 40 246735 32181 90349491
Premature labour 16.30 9.40 8 246767 13368 90368304
Myasthenia gravis 16.13 9.40 48 246727 6777 90374895
Foetal growth restriction 16.12 9.40 3 246772 9377 90372295
Carotid artery stenosis 16.07 9.40 41 246734 5293 90376379
Eye injury 16.05 9.40 5 246770 11015 90370657
Hypophagia 16.05 9.40 159 246616 35778 90345894
Peripheral vascular disorder 15.94 9.40 46 246729 6385 90375287
Dermatomyositis 15.92 9.40 31 246744 3339 90378333
Endometrial disorder 15.79 9.40 15 246760 806 90380866
Malignant melanoma 15.75 9.40 72 246703 12504 90369168
Bursitis infective 15.75 9.40 20 246755 1490 90380182
Haemorrhage subcutaneous 15.75 9.40 31 246744 3365 90378307
Ligament pain 15.72 9.40 9 246766 218 90381454
Urinary incontinence 15.72 9.40 164 246611 37402 90344270
Cranial nerve disorder 15.70 9.40 14 246761 693 90380979
Eructation 15.70 9.40 65 246710 10817 90370855
Haemoptysis 15.65 9.40 149 246626 33171 90348501
Hyperlipasaemia 15.64 9.40 15 246760 816 90380856
Cardiac failure chronic 15.59 9.40 42 246733 5604 90376068
Hyperplastic cholecystopathy 15.53 9.40 8 246767 156 90381516
Potentiating drug interaction 15.51 9.40 42 246733 5620 90376052
Peripheral arterial occlusive disease 15.49 9.40 37 246738 4584 90377088
Granuloma annulare 15.44 9.40 15 246760 829 90380843
Cardiac flutter 15.40 9.40 37 246738 4601 90377071
Nausea 15.35 9.40 3331 243444 1106985 89274687
Cardiac neoplasm unspecified 15.32 9.40 6 246769 59 90381613
Unwanted awareness during anaesthesia 15.28 9.40 11 246764 399 90381273
Hypothyroidism 15.26 9.40 216 246559 52911 90328761
Ventricular extrasystoles 15.24 9.40 74 246701 13176 90368496
Pulmonary function test abnormal 15.20 9.40 27 246748 2712 90378960
Apathy 15.19 9.40 65 246710 10975 90370697
Bronchopulmonary aspergillosis 15.18 9.40 6 246769 11392 90370280
Eyelid oedema 15.17 9.40 67 246708 11467 90370205
Troponin increased 15.15 9.40 74 246701 13207 90368465
Ventricular fibrillation 15.14 9.40 77 246698 13967 90367705
Glomerular filtration rate increased 15.07 9.40 23 246752 2037 90379635
Autonomic neuropathy 15.04 9.40 19 246756 1408 90380264
Mitral valve incompetence 15.02 9.40 109 246666 22415 90359257
Merycism 14.97 9.40 10 246765 321 90381351
Oxygen saturation decreased 14.95 9.40 391 246384 107092 90274580
Adrenocortical insufficiency acute 14.90 9.40 26 246749 2575 90379097
Basophil count increased 14.88 9.40 17 246758 1134 90380538
Blood growth hormone increased 14.86 9.40 12 246763 518 90381154
Dermatitis atopic 14.75 9.40 112 246663 23360 90358312
Illness 14.73 9.40 309 246466 81660 90300012
Musculoskeletal foreign body 14.73 9.40 3 246772 0 90381672
Device issue 14.70 9.40 37 246738 29500 90352172
Abortion induced 14.65 9.40 7 246768 11881 90369791
Pulmonary oedema 14.61 9.40 244 246531 61836 90319836
Skin laceration 14.59 9.40 121 246654 25914 90355758
Malignant neoplasm progression 14.55 9.40 204 246571 106666 90275006
Essential hypertension 14.54 9.40 44 246731 6271 90375401
Paraesthesia 14.53 9.40 546 246229 249780 90131892
Drug resistance 14.50 9.40 39 246736 30410 90351262
Mouth injury 14.49 9.40 17 246758 1167 90380505
Blood bilirubin abnormal 14.46 9.40 22 246753 1942 90379730
Sputum retention 14.42 9.40 13 246762 653 90381019
Head injury 14.42 9.40 139 246636 31049 90350623
Nasal discharge discolouration 14.41 9.40 27 246748 2826 90378846
Clitoris abscess 14.38 9.40 4 246771 11 90381661
Infusion site discomfort 14.32 9.40 21 246754 1795 90379877
Ingrowing nail 14.31 9.40 27 246748 2840 90378832
Carotid artery disease 14.29 9.40 20 246755 1637 90380035
Autoimmune hepatitis 14.28 9.40 61 246714 10290 90371382
Coma acidotic 14.25 9.40 7 246768 123 90381549
Aspiration 14.18 9.40 82 246693 15611 90366061
Cockroach allergy 14.11 9.40 6 246769 74 90381598
Herpes dermatitis 14.09 9.40 7 246768 126 90381546
Atrial tachycardia 14.04 9.40 42 246733 5948 90375724
Product residue present 14.00 9.40 34 246741 4257 90377415
Syncope 13.93 9.40 466 246309 132197 90249475
Aspergillus infection 13.92 9.40 6 246769 10817 90370855
Bundle branch block left 13.74 9.40 50 246725 7835 90373837
Concomitant disease aggravated 13.74 9.40 65 246710 11453 90370219
Hypertriglyceridaemia 13.73 9.40 50 246725 7839 90373833
Jaundice 13.62 9.40 142 246633 32375 90349297
Diabetic nephropathy 13.59 9.40 20 246755 1714 90379958
Chronic lymphocytic leukaemia 13.58 9.40 28 246747 3142 90378530
Skin irritation 13.57 9.40 73 246702 13530 90368142
Anosmia 13.56 9.40 58 246717 9790 90371882
Procedural pain 13.54 9.40 46 246729 33314 90348358
Mean cell volume increased 13.51 9.40 37 246738 4984 90376688
Small fibre neuropathy 13.49 9.40 13 246762 711 90380961
Apolipoprotein B increased 13.44 9.40 4 246771 15 90381657
Supraventricular extrasystoles 13.42 9.40 38 246737 5219 90376453
Hepatitis acute 13.39 9.40 62 246713 10825 90370847
Hypokalaemia 13.37 9.40 459 246316 130657 90251015
Vascular device infection 13.32 9.40 8 246767 11944 90369728
Breast pain 13.32 9.40 60 246715 10358 90371314
Eye infection staphylococcal 13.31 9.40 6 246769 86 90381586
Pharyngeal swelling 13.26 9.40 58 246717 9886 90371786
Eczema 13.26 9.40 210 246565 52660 90329012
Very low density lipoprotein increased 13.25 9.40 7 246768 144 90381528
Erythema marginatum 13.24 9.40 4 246771 16 90381656
Musculoskeletal pain 13.18 9.40 360 246415 170891 90210781
Febrile bone marrow aplasia 13.18 9.40 5 246770 9733 90371939
Urine protein/creatinine ratio increased 13.17 9.40 15 246760 997 90380675
Rheumatoid arthritis 13.14 9.40 831 245944 361783 90019889
Psychiatric symptom 13.14 9.40 46 246729 7072 90374600
Decubitus ulcer 13.04 9.40 8 246767 11805 90369867
Foot fracture 13.01 9.40 120 246655 26486 90355186
Type V hyperlipidaemia 13.00 9.40 14 246761 874 90380798
Oral candidiasis 13 9.40 51 246724 35404 90346268
Aortic valve calcification 12.99 9.40 12 246763 622 90381050
Maternal condition affecting foetus 12.97 9.40 8 246767 223 90381449
Dystonia 12.97 9.40 16 246759 16803 90364869
Blood calcium abnormal 12.97 9.40 21 246754 1956 90379716
Drug specific antibody 12.97 9.40 24 246751 2488 90379184
Migraine 12.96 9.40 407 246368 189985 90191687
Breast cancer stage I 12.92 9.40 5 246770 9619 90372053
Intensive care 12.87 9.40 17 246758 1317 90380355
Pulmonary haemorrhage 12.87 9.40 3 246772 8010 90373662
Tachycardia 12.78 9.40 329 246446 157344 90224328
Gastrointestinal haemorrhage 12.75 9.40 329 246446 89919 90291753
Posterior reversible encephalopathy syndrome 12.73 9.40 26 246749 22313 90359359
Disability assessment scale score increased 12.67 9.40 31 246744 3900 90377772
Neurotrophic keratopathy 12.66 9.40 3 246772 3 90381669
Cardiac valve fibroelastoma 12.66 9.40 3 246772 3 90381669
Gingival pain 12.65 9.40 56 246719 9596 90372076
Tendon pain 12.55 9.40 30 246745 3718 90377954
Faeces discoloured 12.44 9.40 100 246675 21220 90360452
Polyglandular autoimmune syndrome type II 12.43 9.40 5 246770 53 90381619
Localised infection 12.42 9.40 143 246632 33419 90348253
Drug-induced liver injury 12.40 9.40 328 246447 89990 90291682
Lichen planus 12.37 9.40 25 246750 2766 90378906
Blood creatine phosphokinase MB increased 12.35 9.40 16 246759 1216 90380456
Sarcopenia 12.32 9.40 9 246766 334 90381338
Multiple-drug resistance 12.31 9.40 3 246772 7773 90373899
Pharyngitis 12.30 9.40 102 246673 21845 90359827
Hypokinesia 12.27 9.40 79 246696 15618 90366054
Red blood cell sedimentation rate abnormal 12.26 9.40 110 246665 24094 90357578
Blood glucose fluctuation 12.25 9.40 36 246739 5047 90376625
Poisoning 12.25 9.40 14 246761 15203 90366469
Tendon injury 12.23 9.40 22 246753 2231 90379441
Dry age-related macular degeneration 12.22 9.40 8 246767 248 90381424
Pneumococcal infection 12.22 9.40 16 246759 1229 90380443
Croup infectious 12.17 9.40 12 246763 675 90380997
Malignant sweat gland neoplasm 12.13 9.40 6 246769 107 90381565
Steroid dependence 12.12 9.40 22 246753 2247 90379425
Defaecation urgency 12.10 9.40 41 246734 6201 90375471
Gastritis 12.09 9.40 170 246605 41583 90340089
Joint stiffness 12.09 9.40 145 246630 77897 90303775
Coronary arterial stent insertion 12.07 9.40 25 246750 2815 90378857
Sudden hearing loss 12.01 9.40 17 246758 1406 90380266
Haemorrhagic stroke 12.01 9.40 42 246733 6454 90375218
Brain oedema 11.94 9.40 18 246757 17367 90364305
Blood ketone body increased 11.91 9.40 9 246766 352 90381320
Uterine cancer 11.91 9.40 37 246738 5348 90376324
Cytomegalovirus viraemia 11.87 9.40 3 246772 7583 90374089
Renal tubular necrosis 11.84 9.40 74 246701 14481 90367191
Pulseless electrical activity 11.84 9.40 52 246723 8880 90372792
B-lymphocyte abnormalities 11.83 9.40 8 246767 262 90381410
Hepatic encephalopathy 11.83 9.40 12 246763 13760 90367912
Interstitial granulomatous dermatitis 11.81 9.40 5 246770 61 90381611
Tendonitis 11.80 9.40 99 246676 21273 90360399
Gastrooesophageal reflux disease 11.79 9.40 560 246215 165777 90215895
Drug use disorder 11.77 9.40 4 246771 8339 90373333
Left atrial volume increased 11.74 9.40 5 246770 62 90381610
Diabetic retinopathy 11.73 9.40 24 246751 2678 90378994
Vitamin D deficiency 11.73 9.40 85 246690 17471 90364201
Dysphonia 11.72 9.40 239 246536 62845 90318827
High density lipoprotein increased 11.70 9.40 16 246759 1282 90380390
Fluid retention 11.70 9.40 169 246606 87922 90293750
Trimethylaminuria 11.68 9.40 7 246768 185 90381487
Hyperphosphataemia 11.68 9.40 29 246746 3682 90377990
Haematuria 11.68 9.40 146 246629 34791 90346881
Vitamin B1 deficiency 11.67 9.40 10 246765 469 90381203
Hyperparathyroidism secondary 11.64 9.40 19 246756 1782 90379890
Ocular hyperaemia 11.62 9.40 142 246633 33656 90348016
Hepatitis toxic 11.61 9.40 29 246746 3696 90377976
Forced vital capacity abnormal 11.60 9.40 5 246770 64 90381608
Coronary artery bypass 11.57 9.40 22 246753 2327 90379345
Cataract operation 11.53 9.40 40 246735 6123 90375549
Pre-eclampsia 11.49 9.40 8 246767 11040 90370632
Thyroglossal cyst 11.45 9.40 3 246772 6 90381666
Violence-related symptom 11.44 9.40 11 246764 600 90381072
Enterococcus test positive 11.40 9.40 16 246759 1313 90380359
Urine glucose/creatinine ratio increased 11.36 9.40 7 246768 195 90381477
Blood immunoglobulin E decreased 11.36 9.40 7 246768 195 90381477
Acute respiratory distress syndrome 11.34 9.40 40 246735 28646 90353026
Hypomania 11.34 9.40 5 246770 8892 90372780
Memory impairment 11.27 9.40 431 246344 196813 90184859
Gingivitis 11.27 9.40 53 246722 9316 90372356
Dysstasia 11.26 9.40 111 246664 24941 90356731
Rash erythematous 11.25 9.40 118 246657 64986 90316686
Hypercreatininaemia 11.25 9.40 12 246763 741 90380931
Haemorrhoidal haemorrhage 11.25 9.40 36 246739 5287 90376385
Sensorimotor disorder 11.23 9.40 12 246763 743 90380929
Secretion discharge 11.22 9.40 78 246697 15818 90365854
Total bile acids increased 11.21 9.40 6 246769 127 90381545
Blood thyroid stimulating hormone increased 11.16 9.40 52 246723 9103 90372569
Campylobacter test positive 11.16 9.40 4 246771 30 90381642
Excessive cerumen production 11.16 9.40 11 246764 619 90381053
Epistaxis 11.07 9.40 307 246468 84818 90296854
Neutrophil count decreased 11.04 9.40 133 246642 71399 90310273
Smooth muscle antibody positive 11.00 9.40 6 246769 132 90381540
Brain injury 10.99 9.40 46 246729 7692 90373980
Abnormal dreams 10.95 9.40 60 246715 11197 90370475
Acute myeloid leukaemia 10.95 9.40 25 246750 20615 90361057
Lymphangiectasia 10.95 9.40 5 246770 74 90381598
Musculoskeletal discomfort 10.94 9.40 96 246679 20895 90360777
Incorrect dose administered 10.94 9.40 287 246488 78643 90303029
MELAS syndrome 10.93 9.40 7 246768 209 90381463
Renal disorder 10.90 9.40 154 246621 37705 90343967
Myoglobinuria 10.90 9.40 9 246766 401 90381271
Drug dependence 10.87 9.40 42 246733 29285 90352387
Exercise tolerance decreased 10.81 9.40 45 246730 7506 90374166
Nasal ulcer 10.78 9.40 23 246752 2643 90379029
Polyarthritis 10.76 9.40 21 246754 18329 90363343
Carotid arteriosclerosis 10.75 9.40 15 246760 1225 90380447
Intracranial haemangioma 10.72 9.40 4 246771 34 90381638
Rebound psychosis 10.72 9.40 7 246768 216 90381456
Blood triglycerides decreased 10.71 9.40 5 246770 78 90381594
Autoimmune nephritis 10.67 9.40 9 246766 413 90381259
No adverse event 10.65 9.40 126 246649 67856 90313816
Therapeutic response decreased 10.60 9.40 176 246599 89553 90292119
Optic neuropathy 10.60 9.40 23 246752 2675 90378997
Polyp 10.51 9.40 45 246730 7599 90374073
Coronary ostial stenosis 10.49 9.40 5 246770 82 90381590
Hepatic infection 10.45 9.40 11 246764 669 90381003
Muscle fatigue 10.44 9.40 24 246751 2900 90378772
Obstructive pancreatitis 10.44 9.40 11 246764 670 90381002
Hypertensive urgency 10.37 9.40 11 246764 675 90380997
Pulse pressure abnormal 10.36 9.40 3 246772 10 90381662
Pleuritic pain 10.34 9.40 56 246719 10405 90371267
Frequent bowel movements 10.33 9.40 102 246673 56833 90324839
Blood creatine phosphokinase MM increased 10.33 9.40 4 246771 38 90381634
Peripheral coldness 10.30 9.40 69 246706 13823 90367849
Coronary artery restenosis 10.28 9.40 8 246767 327 90381345
Upper respiratory tract congestion 10.28 9.40 21 246754 2341 90379331
Tryptase increased 10.23 9.40 10 246765 557 90381115
Unintended pregnancy 10.20 9.40 4 246771 7633 90374039
Cholestasis 10.19 9.40 147 246628 36152 90345520
Aortic valve stenosis 10.19 9.40 30 246745 4210 90377462
Enthesophyte 10.17 9.40 6 246769 154 90381518
Oesophageal irritation 10.16 9.40 8 246767 333 90381339
Autoimmune neuropathy 10.15 9.40 4 246771 40 90381632
Impaired fasting glucose 10.14 9.40 8 246767 334 90381338
Muscle necrosis 10.13 9.40 12 246763 832 90380840
Joint abscess 10.10 9.40 9 246766 445 90381227
Chronic obstructive pulmonary disease 10.10 9.40 268 246507 73561 90308111
Monocyte count decreased 10.08 9.40 22 246753 2569 90379103
Spinal instability 10.07 9.40 6 246769 157 90381515
Vaginal odour 10.04 9.40 10 246765 570 90381102
Haemorrhoids 9.98 9.40 114 246661 26588 90355084
Foot deformity 9.95 9.40 109 246666 59542 90322130
Urea urine increased 9.93 9.40 3 246772 12 90381660
Atrial septal defect 9.92 9.40 5 246770 8229 90373443
Eye swelling 9.91 9.40 123 246652 29263 90352409
Arteriosclerosis coronary artery 9.90 9.40 52 246723 9551 90372121
Pruritus genital 9.79 9.40 31 246744 4527 90377145
Skin texture abnormal 9.77 9.40 10 246765 589 90381083
Food allergy 9.76 9.40 36 246739 25442 90356230
Bacterial infection 9.74 9.40 32 246743 23412 90358260
Arcus lipoides 9.74 9.40 3 246772 13 90381659
Headache 9.72 9.40 2565 244210 860181 89521491
Neonatal asphyxia 9.72 9.40 8 246767 355 90381317
Circulatory collapse 9.67 9.40 35 246740 24869 90356803
Gastrointestinal toxicity 9.65 9.40 7 246768 9460 90372212
Palliative care 9.64 9.40 12 246763 876 90380796
Cystitis noninfective 9.61 9.40 15 246760 1354 90380318
Pseudohallucination 9.61 9.40 6 246769 171 90381501
Vascular pseudoaneurysm 9.58 9.40 17 246758 1706 90379966
Heart valve calcification 9.56 9.40 3 246772 14 90381658
Blood glucose normal 9.56 9.40 3 246772 14 90381658
Glomerulonephritis minimal lesion 9.55 9.40 8 246767 364 90381308
Thalamus haemorrhage 9.53 9.40 11 246764 742 90380930
Blood urine present 9.52 9.40 80 246695 17198 90364474
Eye infection 9.51 9.40 69 246706 14185 90367487
Shock 9.51 9.40 120 246655 28658 90353014
Genital haemorrhage 9.46 9.40 6 246769 8696 90372976
Bladder cancer 9.45 9.40 36 246739 5765 90375907
Forced expiratory volume decreased 9.43 9.40 36 246739 5772 90375900
White blood cell count abnormal 9.43 9.40 43 246732 7461 90374211
Meningitis aseptic 9.41 9.40 40 246735 6733 90374939

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 1581.35 10.68 2122 202884 93958 42322371
Rhabdomyolysis 1507.62 10.68 1866 203140 76153 42340176
Blood creatine phosphokinase increased 594.33 10.68 931 204075 47407 42368922
Toxicity to various agents 387.89 10.68 320 204686 228816 42187513
Myopathy 347.04 10.68 378 204628 13383 42402946
Drug abuse 316.74 10.68 60 204946 104711 42311618
Death 225.89 10.68 1337 203669 469848 41946481
Low density lipoprotein increased 215.50 10.68 190 204816 5165 42411164
Off label use 189.95 10.68 2062 202944 636273 41780056
Completed suicide 187.48 10.68 116 204890 96349 42319980
High density lipoprotein decreased 187.02 10.68 153 204853 3744 42412585
Neutropenia 174.65 10.68 443 204563 198988 42217341
Disease progression 169.59 10.68 268 204738 143388 42272941
Foetal exposure during pregnancy 159.03 10.68 20 204986 47291 42369038
Low density lipoprotein decreased 158.69 10.68 91 204915 1213 42415116
Coronary artery disease 158.28 10.68 593 204413 53127 42363202
Acute kidney injury 154.31 10.68 2551 202455 364786 42051543
Blood triglycerides increased 148.47 10.68 271 204735 15625 42400704
Full blood count abnormal 148.26 10.68 395 204611 29481 42386848
Pyrexia 143.01 10.68 1211 203795 392831 42023498
Muscle spasms 141.49 10.68 800 204206 85244 42331085
Asthma 135.76 10.68 627 204379 61687 42354642
Angina pectoris 134.96 10.68 406 204600 32490 42383839
Pneumonia 128.96 10.68 1354 203652 420795 41995534
Rheumatoid factor negative 124.03 10.68 71 204935 943 42415386
Overdose 118.92 10.68 202 204804 105062 42311267
Obstructive airways disorder 113.52 10.68 318 204688 24441 42391888
Wheezing 111.87 10.68 541 204465 54240 42362089
Mucosal inflammation 111.24 10.68 49 204957 49325 42367004
Tendon rupture 110.98 10.68 164 204842 7919 42408410
Myocardial infarction 109.99 10.68 993 204013 123016 42293313
Productive cough 109.47 10.68 515 204491 51052 42365277
Drug ineffective 108.85 10.68 2261 202745 627936 41788393
Sepsis 104.09 10.68 549 204457 198785 42217544
Chest discomfort 103.56 10.68 590 204416 63026 42353303
Intentional overdose 102.56 10.68 60 204946 51396 42364933
Multiple organ dysfunction syndrome 101.73 10.68 195 204811 96840 42319489
Pain in extremity 99.48 10.68 1135 203871 149469 42266860
Blood pressure systolic increased 93.65 10.68 322 204684 27646 42388683
Acute myocardial infarction 92.42 10.68 536 204470 57629 42358700
Leukopenia 88.55 10.68 139 204867 74607 42341722
Coronary artery occlusion 87.32 10.68 175 204831 10822 42405507
Seizure 87.07 10.68 293 204713 120268 42296061
Loss of personal independence in daily activities 87.06 10.68 471 204535 49345 42366984
Arteriosclerosis coronary artery 86.72 10.68 241 204765 18436 42397893
Myoglobin blood increased 83.99 10.68 96 204910 3586 42412743
Cardiac failure 82.96 10.68 832 204174 106024 42310305
Arteriosclerosis 82.41 10.68 231 204775 17758 42398571
Erectile dysfunction 81.83 10.68 285 204721 24628 42391701
Conjunctivitis allergic 81.25 10.68 120 204886 5791 42410538
Thrombocytopenia 79.95 10.68 561 204445 189718 42226611
Cardiac failure chronic 77.69 10.68 154 204852 9447 42406882
Septic shock 77.54 10.68 207 204799 91465 42324864
Ascites 76.50 10.68 96 204910 56582 42359747
Muscular weakness 75.71 10.68 672 204334 82826 42333503
Myelosuppression 75.37 10.68 51 204955 40410 42375919
Chromaturia 74.91 10.68 207 204799 15782 42400547
Pancytopenia 74.62 10.68 302 204704 117441 42298888
Cytomegalovirus infection 72.86 10.68 32 204974 32274 42384055
Fractional exhaled nitric oxide increased 72.69 10.68 61 204945 1548 42414781
Hypercholesterolaemia 72.13 10.68 178 204828 12671 42403658
Coronary artery stenosis 71.69 10.68 156 204850 10223 42406106
Angina unstable 71.17 10.68 165 204841 11283 42405046
Mycotic allergy 71.16 10.68 102 204904 4789 42411540
Malignant neoplasm progression 69.98 10.68 276 204730 108124 42308205
Bone marrow failure 69.70 10.68 36 204970 33057 42383272
Arthralgia 69.17 10.68 1378 203628 203860 42212469
Gait spastic 69.04 10.68 56 204950 1353 42414976
Sleep disorder due to a general medical condition 68.38 10.68 212 204794 17241 42399088
Mite allergy 65.87 10.68 100 204906 4946 42411383
Dyspnoea exertional 65.80 10.68 440 204566 49708 42366621
Immune-mediated myositis 65.60 10.68 86 204920 3707 42412622
Autoimmune myositis 65.03 10.68 40 204966 611 42415718
White blood cell count decreased 64.52 10.68 292 204714 110104 42306225
Spirometry abnormal 64.39 10.68 100 204906 5046 42411283
Myositis 64.31 10.68 187 204819 14679 42401650
Glycosylated haemoglobin increased 63.22 10.68 170 204836 12754 42403575
Muscle necrosis 63.10 10.68 47 204959 998 42415331
Premature baby 62.43 10.68 17 204989 23136 42393193
Dust allergy 61.74 10.68 100 204906 5232 42411097
Coma 61.16 10.68 102 204904 53452 42362877
Respiratory failure 60.26 10.68 365 204641 127767 42288562
Diastolic dysfunction 60.14 10.68 115 204891 6868 42409461
Plantar fasciitis 60.04 10.68 74 204932 2996 42413333
Euglycaemic diabetic ketoacidosis 59.97 10.68 102 204904 5558 42410771
Vascular stent stenosis 59.03 10.68 47 204959 1105 42415224
Stenosis 58.78 10.68 61 204945 2040 42414289
Bronchiectasis 58.19 10.68 205 204801 17814 42398515
Needle fatigue 56.90 10.68 47 204959 1166 42415163
Malignant melanoma in situ 56.23 10.68 68 204938 2699 42413630
Blood pressure increased 55.91 10.68 742 204264 101186 42315143
Micturition urgency 55.70 10.68 154 204852 11744 42404585
Reversible airways obstruction 55.07 10.68 35 204971 568 42415761
Normochromic normocytic anaemia 54.87 10.68 129 204877 8902 42407427
Product substitution issue 54.71 10.68 148 204858 11142 42405187
Bone erosion 54.31 10.68 85 204921 4318 42412011
Atrial fibrillation 54.14 10.68 958 204048 138635 42277694
Diabetes mellitus inadequate control 53.99 10.68 180 204826 15210 42401119
Haemophagocytic lymphohistiocytosis 53.83 10.68 11 204995 18211 42398118
Muscle rupture 52.94 10.68 62 204944 2378 42413951
Brain natriuretic peptide increased 52.87 10.68 107 204899 6663 42409666
Infection 52.81 10.68 319 204687 111749 42304580
Appendicolith 52.52 10.68 3 205003 13453 42402876
Suicide attempt 52.46 10.68 88 204918 46012 42370317
Blood cholesterol increased 52.36 10.68 261 204745 26480 42389849
Muscle disorder 52.26 10.68 69 204937 2995 42413334
Hepatojugular reflux 51.28 10.68 35 204971 644 42415685
Rales 50.86 10.68 145 204861 11255 42405074
Crush syndrome 50.74 10.68 18 204988 66 42416263
Drug resistance 50.53 10.68 54 204952 34194 42382135
Neuroleptic malignant syndrome 50.46 10.68 20 204986 21452 42394877
Relapsing-remitting multiple sclerosis 50.32 10.68 48 204958 1447 42414882
Mental status changes 50.17 10.68 78 204928 42037 42374292
Neutrophil count decreased 50.05 10.68 148 204858 63267 42353062
Red blood cell sedimentation rate abnormal 50.05 10.68 76 204930 3760 42412569
Drug dependence 49.87 10.68 40 204966 29054 42387275
Vomiting 49.81 10.68 1039 203967 288684 42127645
Intentional self-injury 49.71 10.68 7 204999 15195 42401134
Blood mercury abnormal 49.21 10.68 25 204981 257 42416072
Encephalopathy 48.81 10.68 77 204929 41256 42375073
Electrocardiogram Q wave abnormal 48.78 10.68 31 204975 503 42415826
Carotid artery stenosis 48.65 10.68 91 204915 5345 42410984
Anaemia 48.51 10.68 1004 204002 279274 42137055
Dizziness 47.58 10.68 1551 203455 247703 42168626
Exercise tolerance decreased 47.52 10.68 96 204910 5970 42410359
Drug ineffective for unapproved indication 46.43 10.68 95 204911 46068 42370261
Colitis ulcerative 46.07 10.68 248 204758 25927 42390402
Neoplasm progression 45.91 10.68 43 204963 28957 42387372
Eosinophilic granulomatosis with polyangiitis 44.66 10.68 116 204890 8522 42407807
Ejection fraction decreased 44.25 10.68 217 204789 21870 42394459
Chest pain 44.03 10.68 928 204078 138602 42277727
Congenital hiatus hernia 44.02 10.68 94 204912 6080 42410249
Carotid arteriosclerosis 43.67 10.68 55 204951 2277 42414052
Tricuspid valve incompetence 43.54 10.68 135 204871 10978 42405351
Sensation of foreign body 43.53 10.68 69 204937 3544 42412785
Computerised tomogram coronary artery abnormal 43.51 10.68 19 204987 134 42416195
Lipoprotein (a) increased 43.22 10.68 25 204981 339 42415990
Hepatic neoplasm 43.15 10.68 53 204953 2138 42414191
Dermatomyositis 42.93 10.68 46 204960 1597 42414732
Cytokine release syndrome 42.80 10.68 94 204912 44433 42371896
No adverse event 42.11 10.68 77 204929 38944 42377385
Psychotic disorder 42.05 10.68 47 204959 29161 42387168
Hyperthyroidism 41.95 10.68 158 204848 14183 42402146
Asthenia 41.57 10.68 1698 203308 279095 42137234
Somnolence 41.48 10.68 456 204550 140649 42275680
Ventricular hypokinesia 41.46 10.68 98 204908 6786 42409543
Product use issue 41.33 10.68 209 204797 76542 42339787
Palpitations 41.07 10.68 399 204607 50398 42365931
Therapy non-responder 41.05 10.68 126 204880 53233 42363096
General physical health deterioration 40.88 10.68 498 204508 150748 42265581
Toxic epidermal necrolysis 40.80 10.68 41 204965 26709 42389620
Respiratory depression 40.52 10.68 20 204986 18848 42397481
Dyslipidaemia 40.28 10.68 118 204888 9300 42407029
Gait disturbance 39.93 10.68 678 204328 97322 42319007
Orbital myositis 39.84 10.68 18 204988 139 42416190
Hypertonic bladder 38.13 10.68 52 204954 2329 42414000
Respiratory distress 38 10.68 91 204915 41729 42374600
Loss of control of legs 37.97 10.68 32 204974 817 42415512
Low density lipoprotein abnormal 37.90 10.68 24 204982 387 42415942
Fractured coccyx 37.87 10.68 18 204988 158 42416171
Thrombotic microangiopathy 37.76 10.68 12 204994 14770 42401559
Drug withdrawal syndrome 37.73 10.68 29 204977 21520 42394809
Ill-defined disorder 37.72 10.68 167 204839 16129 42400200
Occult blood 37.72 10.68 34 204972 952 42415377
Dyspnoea 37.58 10.68 2539 202467 440082 41976247
Eosinophilia 37.50 10.68 279 204727 32620 42383709
Poisoning 37.43 10.68 12 204994 14687 42401642
Drug interaction 37.11 10.68 1604 203402 265395 42150934
Liver injury 36.86 10.68 186 204820 18962 42397367
Muscle discomfort 36.69 10.68 19 204987 204 42416125
Acute coronary syndrome 36.45 10.68 155 204851 14710 42401619
Low cardiac output syndrome 36.36 10.68 28 204978 626 42415703
Tumour lysis syndrome 36.34 10.68 32 204974 22199 42394130
Amyotrophic lateral sclerosis 36.10 10.68 35 204971 1077 42415252
Discomfort 35.96 10.68 226 204780 24993 42391336
5-hydroxyindolacetic acid in urine increased 35.86 10.68 18 204988 180 42416149
Febrile neutropenia 35.81 10.68 653 204353 185050 42231279
Helicobacter gastritis 35.47 10.68 38 204968 1319 42415010
Posterior reversible encephalopathy syndrome 35.35 10.68 9 204997 12812 42403517
Middle insomnia 35.30 10.68 100 204906 7733 42408596
Treatment failure 35.17 10.68 168 204838 62456 42353873
Seronegative arthritis 35.08 10.68 36 204970 1188 42415141
Nodule 34.94 10.68 136 204870 12398 42403931
Staphylococcal infection 34.93 10.68 81 204925 37562 42378767
Impaired quality of life 34.89 10.68 148 204858 14029 42402300
Diabetic ketoacidosis 34.78 10.68 205 204801 22162 42394167
Blood glucose increased 34.57 10.68 522 204484 73177 42343152
Type 2 diabetes mellitus 34.56 10.68 178 204828 18293 42398036
Mitral valve incompetence 34.47 10.68 164 204842 16325 42400004
Respiratory arrest 34.47 10.68 52 204954 28372 42387957
Candida infection 34.26 10.68 32 204974 21578 42394751
Miosis 34.20 10.68 11 204995 13435 42402894
Neutropenic sepsis 34.09 10.68 17 204989 15929 42400400
Presyncope 34.05 10.68 204 204802 22183 42394146
Incorrect route of product administration 34.02 10.68 40 204966 24265 42392064
Platelet count decreased 33.86 10.68 466 204540 138115 42278214
Impaired work ability 33.55 10.68 131 204875 11960 42404369
Blood pressure fluctuation 33.44 10.68 233 204773 26675 42389654
Cytomegalovirus viraemia 33.41 10.68 5 205001 10372 42405957
Drug use disorder 33.22 10.68 5 205001 10328 42406001
Lung diffusion test decreased 33.01 10.68 30 204976 849 42415480
Sedation 33.01 10.68 60 204946 30415 42385914
Post transplant lymphoproliferative disorder 32.82 10.68 3 205003 9117 42407212
N-terminal prohormone brain natriuretic peptide abnormal 32.53 10.68 18 204988 223 42416106
Troponin increased 32.46 10.68 179 204827 18883 42397446
Ventricular extrasystoles 32.35 10.68 139 204867 13251 42403078
Diabetes mellitus 32.34 10.68 436 204570 59651 42356678
Product use in unapproved indication 32.08 10.68 660 204346 183796 42232533
Hepatic enzyme increased 31.96 10.68 349 204657 45435 42370894
Haemorrhagic stroke 31.91 10.68 93 204913 7309 42409020
Supine hypertension 31.85 10.68 21 204985 364 42415965
Transient ischaemic attack 31.83 10.68 274 204732 33465 42382864
Bronchopulmonary aspergillosis 31.72 10.68 28 204978 19401 42396928
Necrotising myositis 31.69 10.68 33 204973 1108 42415221
Breath sounds abnormal 31.14 10.68 128 204878 11965 42404364
Device related infection 31.02 10.68 31 204975 20248 42396081
Blood thyroid stimulating hormone abnormal 30.83 10.68 21 204985 385 42415944
Pneumocystis jirovecii pneumonia 30.60 10.68 46 204960 25135 42391194
Cytomegalovirus infection reactivation 30.53 10.68 8 204998 11170 42405159
Steroid dependence 30.47 10.68 86 204920 6636 42409693
Pericardial disease 30.45 10.68 23 204983 499 42415830
Enterococcal infection 30.35 10.68 10 204996 12029 42404300
Acute respiratory distress syndrome 30.24 10.68 62 204944 30046 42386283
Total cholesterol/HDL ratio increased 29.79 10.68 16 204990 186 42416143
Agitation 29.79 10.68 184 204822 64130 42352199
Pathogen resistance 29.78 10.68 9 204997 11441 42404888
Chronic kidney disease 29.77 10.68 353 204653 46888 42369441
Depressed level of consciousness 29.76 10.68 124 204882 47846 42368483
Serotonin syndrome 29.71 10.68 49 204957 25796 42390533
Cough 29.61 10.68 1091 203915 177012 42239317
Tachycardia 29.56 10.68 327 204679 100760 42315569
Gingival pain 29.49 10.68 99 204907 8395 42407934
Cardiac discomfort 29.35 10.68 26 204980 711 42415618
Substance abuse 29.35 10.68 4 205002 8901 42407428
Gastrooesophageal reflux disease 29.07 10.68 338 204668 44685 42371644
Burns second degree 28.63 10.68 79 204927 6017 42410312
Cardio-respiratory arrest 28.62 10.68 165 204841 58471 42357858
Aplastic anaemia 28.35 10.68 12 204994 12372 42403957
Left ventricular dysfunction 28.25 10.68 120 204886 11381 42404948
Musculoskeletal discomfort 28.21 10.68 105 204901 9371 42406958
Blood pressure inadequately controlled 28.18 10.68 50 204956 2818 42413511
Coronary artery restenosis 28.03 10.68 28 204978 894 42415435
Pulmonary valve disease 27.83 10.68 20 204986 401 42415928
Tinnitus 27.82 10.68 236 204770 28702 42387627
Stomatitis 27.69 10.68 136 204870 50193 42366136
Bundle branch block left 27.56 10.68 81 204925 6395 42409934
Bacterial infection 27.50 10.68 58 204948 27821 42388508
Right atrial enlargement 27.01 10.68 17 204989 271 42416058
Withdrawal syndrome 27.01 10.68 19 204987 14756 42401573
Rhinitis perennial 26.96 10.68 15 204991 188 42416141
Transplant rejection 26.85 10.68 16 204990 13572 42402757
Appendicitis 26.69 10.68 36 204970 20577 42395752
Intentional product misuse 26.68 10.68 181 204825 61719 42354610
Neuritis 26.67 10.68 78 204928 6142 42410187
Skin laceration 26.66 10.68 136 204870 13922 42402407
Catarrh 26.57 10.68 76 204930 5910 42410419
Arthritis 26.36 10.68 314 204692 41751 42374578
Pancreatitis 26.25 10.68 321 204685 42947 42373382
Plasma cell myeloma 25.92 10.68 129 204877 47449 42368880
Monoparesis 25.80 10.68 49 204957 2911 42413418
Blood triglycerides abnormal 25.75 10.68 16 204990 249 42416080
Peritonitis 25.72 10.68 31 204975 18602 42397727
Delusion 25.57 10.68 20 204986 14714 42401615
Carcinoid tumour 25.53 10.68 16 204990 253 42416076
Blood cholesterol abnormal 25.52 10.68 39 204967 1940 42414389
Glomerular filtration rate decreased 25.51 10.68 150 204856 16201 42400128
Cardiac arrest 25.49 10.68 371 204635 108949 42307380
Abnormal behaviour 25.29 10.68 56 204950 26395 42389934
Paraesthesia 25.27 10.68 495 204511 72964 42343365
Nipple inflammation 25.27 10.68 10 204996 53 42416276
Unresponsive to stimuli 24.98 10.68 73 204933 31330 42384999
Multiple-drug resistance 24.83 10.68 3 205003 7319 42409010
Condition aggravated 24.77 10.68 1014 203992 259740 42156589
High density lipoprotein abnormal 24.67 10.68 10 204996 57 42416272
Lipoma 24.62 10.68 40 204966 2098 42414231
Brain natriuretic peptide abnormal 24.58 10.68 18 204988 372 42415957
Parosmia 24.40 10.68 87 204919 7604 42408725
Movement disorder 24.34 10.68 137 204869 14561 42401768
Aortic aneurysm 24.19 10.68 87 204919 7636 42408693
Haemolysis 24.11 10.68 8 204998 9581 42406748
Physical examination abnormal 24.03 10.68 19 204987 442 42415887
Low birth weight baby 23.84 10.68 9 204997 9946 42406383
Dysphagia 23.81 10.68 229 204777 72490 42343839
Systolic dysfunction 23.81 10.68 48 204958 2980 42413349
Epilepsy 23.73 10.68 57 204949 26114 42390215
Therapeutic product effect incomplete 23.72 10.68 476 204530 70463 42345866
Blood cholesterol decreased 23.68 10.68 28 204978 1085 42415244
Status epilepticus 23.61 10.68 24 204982 15554 42400775
Rhinitis 23.51 10.68 117 204889 11860 42404469
Pollakiuria 23.49 10.68 187 204819 22318 42394011
Left ventricular hypertrophy 23.49 10.68 98 204908 9221 42407108
Myopathy toxic 23.45 10.68 23 204983 718 42415611
Hyperphosphataemia 23.41 10.68 17 204989 12987 42403342
Transaminases abnormal 23.18 10.68 16 204990 300 42416029
Pancreatitis necrotising 23.13 10.68 53 204953 3596 42412733
Left ventricular enlargement 22.99 10.68 24 204982 808 42415521
Immune reconstitution inflammatory syndrome 22.94 10.68 10 204996 10133 42406196
Dyspnoea at rest 22.94 10.68 58 204948 4191 42412138
Inspiratory capacity abnormal 22.91 10.68 11 204995 99 42416230
Klebsiella infection 22.88 10.68 13 204993 11319 42405010
Breast pain 22.79 10.68 33 204973 1564 42414765
BK virus infection 22.67 10.68 7 204999 8777 42407552
Angiocardiogram 22.64 10.68 14 204992 216 42416113
Exostosis 22.61 10.68 69 204937 5562 42410767
Cystitis haemorrhagic 22.55 10.68 4 205002 7325 42409004
Syncope 22.52 10.68 632 204374 98774 42317555
Plasmapheresis 22.47 10.68 18 204988 427 42415902
Fatigue 22.34 10.68 2407 202599 433234 41983095
Melanoderma 22.24 10.68 13 204993 180 42416149
Vertigo 22.23 10.68 258 204748 34089 42382240
Aspergillus infection 22.23 10.68 26 204980 15811 42400518
Progressive multifocal leukoencephalopathy 22.21 10.68 14 204992 11522 42404807
Nodular rash 21.91 10.68 11 204995 110 42416219
Hepatic function abnormal 21.81 10.68 359 204647 51208 42365121
Lipids increased 21.77 10.68 28 204978 1184 42415145
Haematocrit increased 21.77 10.68 42 204964 2525 42413804
Heart rate decreased 21.72 10.68 270 204736 36262 42380067
Pulmonary haemorrhage 21.71 10.68 14 204992 11383 42404946
Head titubation 21.64 10.68 18 204988 451 42415878
Drug-induced liver injury 21.53 10.68 280 204726 37993 42378336
Benign prostatic hyperplasia 21.47 10.68 174 204832 20878 42395451
Skin toxicity 21.45 10.68 3 205003 6546 42409783
Job change 21.45 10.68 6 205000 7 42416322
Secretion discharge 21.41 10.68 83 204923 7552 42408777
Muscle rigidity 21.40 10.68 16 204990 12043 42404286
Behaviour disorder 21.38 10.68 4 205002 7050 42409279
Lactic acidosis 21.38 10.68 321 204685 44940 42371389
Hepatitis C 21.37 10.68 11 204995 10122 42406207
Left ventricular dilatation 21.31 10.68 24 204982 882 42415447
Pulmonary alveolar haemorrhage 21.26 10.68 133 204873 14683 42401646
Oesophageal carcinoma 21.24 10.68 10 204996 9686 42406643
Guillain-Barre syndrome 21.22 10.68 80 204926 7183 42409146
Restenosis 21.01 10.68 6 205000 8 42416321
Atrial septal defect 21.00 10.68 6 205000 7913 42408416
Diabetic neuropathy 20.80 10.68 58 204948 4444 42411885
Ventricular arrhythmia 20.76 10.68 72 204934 6207 42410122
Aggression 20.63 10.68 126 204880 44037 42372292
Growth hormone deficiency 20.36 10.68 15 204991 313 42416016
Pneumonia aspiration 20.33 10.68 149 204857 49929 42366400
Hypophosphataemia 20.30 10.68 44 204962 20901 42395428
Therapy partial responder 20.30 10.68 41 204965 19980 42396349
Walking disability 20.18 10.68 27 204979 1187 42415142
Hepatic encephalopathy 20.01 10.68 30 204976 16412 42399917
Pulmonary vasculitis 19.98 10.68 71 204935 6195 42410134
Acute hepatic failure 19.97 10.68 32 204974 17041 42399288
Hypopnoea 19.95 10.68 83 204923 7799 42408530
Poisoning deliberate 19.93 10.68 12 204994 10122 42406207
Pulmonary arterial pressure abnormal 19.88 10.68 15 204991 325 42416004
Mucormycosis 19.72 10.68 5 205001 7138 42409191
N-terminal prohormone brain natriuretic peptide increased 19.55 10.68 48 204958 3405 42412924
Adjustment disorder 19.54 10.68 28 204978 1314 42415015
Nodular melanoma 19.41 10.68 12 204994 185 42416144
Vascular stent thrombosis 19.36 10.68 46 204960 3196 42413133
5-hydroxyindolacetic acid increased 19.34 10.68 10 204996 107 42416222
Chronic obstructive pulmonary disease 19.31 10.68 418 204588 62696 42353633
Prinzmetal angina 19.30 10.68 28 204978 1329 42415000
Renal phospholipidosis 19.29 10.68 11 204995 145 42416184
Electrocardiogram abnormal 19.14 10.68 98 204908 10047 42406282
Glomerular filtration rate 19.10 10.68 10 204996 110 42416219
Pancreatitis acute 19.07 10.68 246 204760 33318 42383011
Hyperammonaemia 19.03 10.68 7 204999 7859 42408470
Oxygen saturation increased 19.01 10.68 14 204992 292 42416037
Muscle spasticity 19.00 10.68 74 204932 6748 42409581
Parkinsonism 18.97 10.68 14 204992 10609 42405720
Platelet distribution width increased 18.96 10.68 11 204995 150 42416179
Forced vital capacity decreased 18.94 10.68 23 204983 917 42415412
Muscle injury 18.87 10.68 31 204975 1641 42414688
Intercepted product preparation error 18.87 10.68 6 205000 7383 42408946
Anastomotic infection 18.79 10.68 10 204996 114 42416215
Intermittent claudication 18.75 10.68 39 204967 2476 42413853
Cerebrovascular accident 18.58 10.68 605 204401 96555 42319774
Mean platelet volume increased 18.56 10.68 19 204987 625 42415704
Osteonecrosis of jaw 18.48 10.68 40 204966 19009 42397320
Epstein-Barr virus infection 18.43 10.68 12 204994 9706 42406623
Hypogammaglobulinaemia 18.39 10.68 18 204988 11873 42404456
Interstitial lung disease 18.37 10.68 501 204505 77961 42338368
AST/ALT ratio abnormal 18.33 10.68 6 205000 16 42416313
Tendonitis 18.27 10.68 95 204911 9799 42406530
Ligament pain 18.25 10.68 8 204998 57 42416272
Acute myeloid leukaemia 18.24 10.68 51 204955 22205 42394124
Frequent bowel movements 18.22 10.68 170 204836 21237 42395092
Aortic valve incompetence 18.21 10.68 71 204935 6477 42409852
Joint injury 18.18 10.68 127 204879 14549 42401780
Drug tolerance decreased 18.07 10.68 37 204969 2323 42414006
Food aversion 18.05 10.68 17 204989 504 42415825
Pulmonary function test abnormal 18.05 10.68 40 204966 2654 42413675
Body temperature decreased 18.02 10.68 125 204881 14288 42402041
Hyponatraemia 17.93 10.68 362 204644 101100 42315229
Haematuria 17.74 10.68 383 204623 57416 42358913
Infusion related reaction 17.65 10.68 197 204809 60609 42355720
Therapeutic product effect decreased 17.61 10.68 113 204893 39037 42377292
Pruritus 17.59 10.68 1092 203914 187679 42228650
Drug intolerance 17.57 10.68 509 204497 79915 42336414
Salmonella bacteraemia 17.54 10.68 16 204990 455 42415874
Systemic lupus erythematosus 17.54 10.68 90 204916 9234 42407095
Cerebral haemorrhage 17.50 10.68 274 204732 38692 42377637
Kidney transplant rejection 17.47 10.68 10 204996 8673 42407656
Abdominal discomfort 17.47 10.68 480 204526 74775 42341554
Helicobacter test false negative 17.47 10.68 8 204998 64 42416265
Mycobacterium test positive 17.40 10.68 16 204990 460 42415869
Muscle atrophy 17.36 10.68 83 204923 8278 42408051
Diabetic metabolic decompensation 17.35 10.68 34 204972 2068 42414261
Orthostatic hypotension 17.35 10.68 224 204782 30346 42385983
Ventricular hyperkinesia 17.34 10.68 12 204994 226 42416103
Stevens-Johnson syndrome 17.32 10.68 52 204954 22126 42394203
Hallucination 17.21 10.68 185 204821 57322 42359007
Arrhythmia 17.16 10.68 281 204725 40036 42376293
Hereditary haemorrhagic telangiectasia 17.11 10.68 7 204999 41 42416288
Antineutrophil cytoplasmic antibody positive 17.08 10.68 53 204953 4312 42412017
Hospitalisation 17.06 10.68 253 204753 74077 42342252
Meningitis eosinophilic 16.92 10.68 6 205000 22 42416307
Musculoskeletal stiffness 16.85 10.68 380 204626 57385 42358944
High density lipoprotein increased 16.82 10.68 15 204991 414 42415915
Paraplegia 16.76 10.68 44 204962 3253 42413076
Balance disorder 16.70 10.68 322 204684 47323 42369006
Pseudomonas infection 16.67 10.68 32 204974 15891 42400438
Hypoalbuminaemia 16.67 10.68 31 204975 15579 42400750
Degenerative bone disease 16.66 10.68 8 204998 72 42416257
Myocardial ischaemia 16.62 10.68 144 204862 17618 42398711
Atrial enlargement 16.61 10.68 19 204987 710 42415619
Haemoglobin increased 16.61 10.68 59 204947 5147 42411182
Xanthoma 16.37 10.68 9 204997 110 42416219
Hypoaesthesia 16.36 10.68 455 204551 71008 42345321
Hallucination, auditory 16.33 10.68 29 204977 14835 42401494
Decreased ventricular preload 16.32 10.68 6 205000 25 42416304
Malnutrition 16.32 10.68 28 204978 14514 42401815
Mania 16.27 10.68 16 204990 10531 42405798
Blood pressure systolic abnormal 16.24 10.68 61 204945 5467 42410862
Meningitis aseptic 16.24 10.68 53 204953 4429 42411900
Brain oedema 16.07 10.68 34 204972 16293 42400036
Dysgeusia 15.96 10.68 242 204764 33947 42382382
Nervous system disorder 15.95 10.68 37 204969 17158 42399171
Cardiac disorder 15.91 10.68 327 204679 48605 42367724
Myelodysplastic syndrome 15.91 10.68 56 204950 22689 42393640
Hypochromasia 15.89 10.68 13 204993 318 42416011
Coagulopathy 15.88 10.68 54 204952 22108 42394221
Generalised tonic-clonic seizure 15.86 10.68 69 204937 26310 42390019
Percutaneous coronary intervention 15.75 10.68 12 204994 264 42416065
Urine albumin/creatinine ratio increased 15.74 10.68 16 204990 522 42415807
Body temperature increased 15.71 10.68 48 204958 20310 42396019
Very low density lipoprotein increased 15.68 10.68 8 204998 83 42416246
Stent placement 15.63 10.68 59 204947 5301 42411028
Nipple disorder 15.55 10.68 11 204995 215 42416114
Vascular device infection 15.53 10.68 5 205001 6105 42410224
Autoimmune hepatitis 15.53 10.68 61 204945 5584 42410745
Arterial spasm 15.52 10.68 8 204998 85 42416244
Cerebral infarction 15.48 10.68 223 204783 30946 42385383
Extrasystoles 15.45 10.68 50 204956 4159 42412170
Eczema 15.42 10.68 240 204766 33846 42382483
Aldolase increased 15.39 10.68 7 204999 55 42416274
Mitral valve thickening 15.38 10.68 15 204991 465 42415864
Polyomavirus-associated nephropathy 15.37 10.68 4 205002 5611 42410718
Left atrial dilatation 15.35 10.68 35 204971 2367 42413962
Ureteric cancer 15.33 10.68 11 204995 220 42416109
Viral infection 15.30 10.68 56 204950 22427 42393902
Sleep disorder therapy 15.27 10.68 7 204999 6887 42409442
Neuropathy peripheral 15.25 10.68 373 204633 101480 42314849
Encephalitis 15.19 10.68 13 204993 9145 42407184
Lymphomatoid papulosis 14.87 10.68 11 204995 231 42416098
Haemoglobin decreased 14.81 10.68 505 204501 131966 42284363
Lethargy 14.79 10.68 149 204857 46741 42369588
FEV1/FVC ratio decreased 14.77 10.68 9 204997 135 42416194
Renal tubular necrosis 14.75 10.68 144 204862 18210 42398119
Dysphonia 14.71 10.68 205 204801 28245 42388084
Cardiovascular somatic symptom disorder 14.69 10.68 6 205000 35 42416294
Gamma-glutamyltransferase decreased 14.69 10.68 6 205000 35 42416294
Blood chloride increased 14.68 10.68 44 204962 3512 42412817
Prohormone brain natriuretic peptide increased 14.68 10.68 8 204998 96 42416233
Tongue oedema 14.66 10.68 42 204964 3268 42413061
Intensive care 14.66 10.68 23 204983 1171 42415158
Acute respiratory failure 14.65 10.68 118 204888 38740 42377589
Dermatitis atopic 14.59 10.68 106 204900 12298 42404031
Phonophobia 14.58 10.68 12 204994 296 42416033
Sinus pain 14.44 10.68 20 204986 909 42415420
Cardiac murmur 14.36 10.68 108 204898 12667 42403662
Retroperitoneal fibrosis 14.25 10.68 14 204992 438 42415891
Inappropriate antidiuretic hormone secretion 14.24 10.68 37 204969 16504 42399825
Nail discolouration 14.19 10.68 23 204983 1204 42415125
Varicella zoster pneumonia 14.09 10.68 11 204995 251 42416078
Chronic cutaneous lupus erythematosus 14.06 10.68 9 204997 148 42416181
Blood creatine phosphokinase 14.06 10.68 8 204998 105 42416224
Agranulocytosis 13.95 10.68 88 204918 30524 42385805
Cardiac autonomic neuropathy 13.95 10.68 7 204999 70 42416259
Psoriasis 13.95 10.68 319 204687 48285 42368044
Base excess decreased 13.94 10.68 10 204996 200 42416129
Electrocardiogram QRS complex abnormal 13.91 10.68 14 204992 451 42415878
Hepatitis E antibody positive 13.91 10.68 11 204995 256 42416073
Mydriasis 13.88 10.68 13 204993 8757 42407572
Immune effector cell-associated neurotoxicity syndrome 13.86 10.68 15 204991 9446 42406883
Blood pressure ambulatory increased 13.86 10.68 7 204999 71 42416258
Graft versus host disease in skin 13.73 10.68 4 205002 5208 42411121
Inappropriate schedule of product administration 13.69 10.68 578 204428 95324 42321005
Cytopenia 13.68 10.68 41 204965 17456 42398873
Prostatic haemorrhage 13.66 10.68 11 204995 263 42416066
Electrocardiogram QT prolonged 13.65 10.68 156 204850 47789 42368540
Joint destruction 13.62 10.68 13 204993 392 42415937
Echocardiogram abnormal 13.60 10.68 23 204983 1247 42415082
Lung disorder 13.59 10.68 314 204692 47609 42368720
Blood pressure diastolic abnormal 13.58 10.68 62 204944 6066 42410263
Deprescribing error 13.57 10.68 5 205001 21 42416308
Myoglobinuria 13.57 10.68 18 204988 785 42415544
Neurotoxicity 13.54 10.68 63 204943 23588 42392741
Palmar-plantar erythrodysaesthesia syndrome 13.52 10.68 52 204954 20530 42395799
Lipase increased 13.43 10.68 92 204914 10474 42405855
Fistula 13.41 10.68 11 204995 7901 42408428
Oral candidiasis 13.36 10.68 31 204975 14374 42401955
Pseudocellulitis 13.35 10.68 11 204995 272 42416057
Psychomotor hyperactivity 13.33 10.68 20 204986 10938 42405391
Supraventricular extrasystoles 13.30 10.68 46 204960 3960 42412369
Metabolic acidosis 13.26 10.68 335 204671 51523 42364806
Eosinophil count increased 13.25 10.68 93 204913 10670 42405659
Histamine level increased 13.21 10.68 7 204999 79 42416250
Clostridium difficile colitis 13.14 10.68 55 204951 21197 42395132
Right ventricular failure 13.08 10.68 16 204990 9539 42406790
Fibrous histiocytoma 13.08 10.68 12 204994 344 42415985
Lung infiltration 13.06 10.68 30 204976 13959 42402370
Cardiotoxicity 13.06 10.68 10 204996 7435 42408894
Heliotrope rash 13.04 10.68 5 205001 24 42416305
Blood triglycerides 13.03 10.68 3 205003 0 42416329
Blood bilirubin increased 13.02 10.68 135 204871 42117 42374212
Blood pressure diastolic decreased 12.98 10.68 90 204916 10285 42406044
Psychotic disorder due to a general medical condition 12.92 10.68 7 204999 83 42416246
Pulmonary fibrosis 12.90 10.68 190 204816 26491 42389838
Blood pressure diastolic increased 12.88 10.68 63 204943 6342 42409987
Mobility decreased 12.85 10.68 240 204766 35066 42381263
Fungal infection 12.85 10.68 50 204956 19672 42396657
Blood thyroid stimulating hormone increased 12.83 10.68 55 204951 5237 42411092
Ileus 12.80 10.68 48 204958 19091 42397238
Left atrial enlargement 12.79 10.68 20 204986 1015 42415314
Leukocytosis 12.73 10.68 87 204919 29621 42386708
Hypertension 12.70 10.68 951 204055 166253 42250076
Diabetic foot 12.66 10.68 38 204968 3035 42413294
Swollen tongue 12.65 10.68 157 204849 21074 42395255
Hepatitis E virus test positive 12.54 10.68 11 204995 297 42416032
Hepatic failure 12.46 10.68 120 204886 37980 42378349
Analgesic therapy 12.45 10.68 8 204998 6516 42409813
Oxygen consumption decreased 12.44 10.68 11 204995 300 42416029
Streptococcal infection 12.43 10.68 7 204999 6125 42410204
Emotional distress 12.37 10.68 38 204968 16055 42400274
Oropharyngeal discomfort 12.37 10.68 46 204960 4103 42412226
Weight decreased 12.35 10.68 1161 203845 206787 42209542
Tongue dry 12.32 10.68 11 204995 304 42416025
Nocturia 12.29 10.68 100 204906 12012 42404317
Expired product administered 12.29 10.68 46 204960 4117 42412212
Foetal growth restriction 12.28 10.68 5 205001 5278 42411051
Bradypnoea 12.28 10.68 3 205003 4390 42411939
Tendon disorder 12.21 10.68 40 204966 3349 42412980
Oncologic complication 12.16 10.68 13 204993 450 42415879
Oedema genital 12.08 10.68 14 204992 531 42415798
Urine odour abnormal 12.07 10.68 25 204981 1583 42414746
Lipids abnormal 12.05 10.68 13 204993 455 42415874
Gastroduodenal ulcer 12.04 10.68 16 204990 699 42415630
Disseminated intravascular coagulation 11.97 10.68 70 204936 24724 42391605
Craniofacial fracture 11.97 10.68 12 204994 385 42415944
Hyperkalaemia 11.96 10.68 487 204519 79971 42336358
Drug therapy 11.93 10.68 8 204998 6372 42409957
Decubitus ulcer 11.91 10.68 20 204986 10457 42405872
Obsessive-compulsive disorder 11.90 10.68 9 204997 6734 42409595
Gamma-glutamyltransferase 11.88 10.68 4 205002 12 42416317
Nephrectomy 11.87 10.68 18 204988 889 42415440
Conjunctivitis 11.87 10.68 28 204978 12911 42403418
Foreign body in throat 11.85 10.68 14 204992 542 42415787
Ischaemic stroke 11.82 10.68 161 204845 22072 42394257
Blood creatine phosphokinase MB increased 11.81 10.68 28 204978 1942 42414387
Atrial thrombosis 11.80 10.68 32 204974 2412 42413917
Sopor 11.78 10.68 29 204977 13173 42403156
Defect conduction intraventricular 11.75 10.68 13 204993 468 42415861
Lid sulcus deepened 11.67 10.68 7 204999 102 42416227
Musculoskeletal toxicity 11.59 10.68 8 204998 150 42416179
Hypothermia 11.55 10.68 27 204979 12488 42403841
Polymyositis 11.51 10.68 26 204980 1747 42414582
Fear 11.51 10.68 22 204984 10943 42405386
Peripheral arterial occlusive disease 11.50 10.68 64 204942 6774 42409555
Blood urine present 11.44 10.68 96 204910 11637 42404692
Lymphopenia 11.44 10.68 59 204947 21504 42394825
Vasculitis 11.39 10.68 137 204869 18257 42398072
Total cholesterol/HDL ratio decreased 11.38 10.68 6 205000 67 42416262
Device leakage 11.36 10.68 20 204986 10265 42406064
Bradykinesia 11.32 10.68 6 205000 5430 42410899
Electrocardiogram QRS complex prolonged 11.30 10.68 7 204999 5816 42410513
Idiopathic pulmonary fibrosis 11.28 10.68 48 204958 4556 42411773
Intestinal perforation 11.25 10.68 22 204984 10852 42405477
Aspiration 11.24 10.68 46 204960 17840 42398489
Abscess of salivary gland 11.21 10.68 4 205002 15 42416314
Drug screen positive 11.20 10.68 3 205003 4128 42412201
Sinusitis 11.19 10.68 160 204846 47132 42369197
Blood follicle stimulating hormone increased 11.18 10.68 9 204997 215 42416114
Cerebral haematoma 11.15 10.68 55 204951 5555 42410774
Coma scale abnormal 11.15 10.68 4 205002 4561 42411768
Anion gap abnormal 11.01 10.68 12 204994 425 42415904
Episcleral venous pressure increased 11.01 10.68 4 205002 16 42416313
Chemical burns of eye 11.01 10.68 4 205002 16 42416313
Neurological symptom 10.97 10.68 84 204922 9907 42406422
Lipoprotein (a) abnormal 10.96 10.68 3 205003 3 42416326
Sclerodactylia 10.92 10.68 5 205001 40 42416289
Pseudohallucination 10.92 10.68 5 205001 40 42416289
Increased upper airway secretion 10.91 10.68 32 204974 2524 42413805
Heparin-induced thrombocytopenia test 10.90 10.68 8 204998 166 42416163
Albuminuria 10.89 10.68 14 204992 592 42415737
Respiratory syncytial virus infection 10.86 10.68 11 204995 7141 42409188
Body mass index abnormal 10.86 10.68 8 204998 167 42416162
Blood phosphorus increased 10.79 10.68 28 204978 12497 42403832
Gynaecomastia 10.79 10.68 100 204906 12467 42403862
Mitral valve disease 10.78 10.68 23 204983 1487 42414842
Electrolyte imbalance 10.73 10.68 44 204962 17057 42399272
Pleural effusion 10.72 10.68 371 204635 96795 42319534
Bone cancer 10.69 10.68 26 204980 1833 42414496

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 3223.56 9.74 2969 389261 117432 110079637
Myalgia 2617.47 9.74 3569 388661 218812 109978257
Blood creatine phosphokinase increased 1092.64 9.74 1322 390908 71755 110125314
Maternal exposure during pregnancy 752.92 9.74 36 392194 254847 109942222
Acute kidney injury 664.35 9.74 4186 388044 631244 109565825
Pemphigus 612.81 9.74 37 392193 214533 109982536
Glossodynia 608.61 9.74 47 392183 221957 109975112
Hand deformity 605.44 9.74 44 392186 218462 109978607
Myopathy 585.95 9.74 573 391657 24387 110172682
Anti-cyclic citrullinated peptide antibody positive 563.52 9.74 18 392212 181966 110015103
Duodenal ulcer perforation 555.96 9.74 16 392214 177684 110019385
Synovitis 538.94 9.74 152 392078 273940 109923129
Folliculitis 500.51 9.74 22 392208 167631 110029438
Systemic lupus erythematosus 481.89 9.74 151 392079 254187 109942882
Helicobacter infection 475.42 9.74 47 392183 181830 110015239
Wound 470.26 9.74 125 392105 234312 109962757
Pericarditis 420.63 9.74 127 392103 218987 109978082
Rheumatic fever 407.66 9.74 5 392225 122574 110074495
Impaired healing 405.84 9.74 99 392131 196618 110000451
Exposure during pregnancy 394.35 9.74 61 392169 167363 110029706
Asthma 384.16 9.74 1832 390398 248459 109948610
Creatinine renal clearance decreased 383.34 9.74 429 391801 21386 110175683
Angina pectoris 376.97 9.74 741 391489 61554 110135515
Sedation complication 370.58 9.74 403 391827 19452 110177617
Irritable bowel syndrome 366.58 9.74 69 392161 164146 110032923
Infusion related reaction 358.48 9.74 497 391733 380665 109816404
Treatment failure 357.26 9.74 276 391954 276958 109920111
Orthostatic hypotension 336.22 9.74 733 391497 65516 110131553
Muscle injury 334.59 9.74 50 392180 140757 110056312
Facet joint syndrome 326.35 9.74 3 392227 96825 110100244
Full blood count abnormal 313.19 9.74 645 391585 55407 110141662
Therapeutic product effect decreased 312.52 9.74 245 391985 244071 109952998
Blood pressure increased 302.02 9.74 1754 390476 256619 109940450
Off label use 297.57 9.74 3653 388577 1496532 108700537
Stomatitis 296.84 9.74 312 391918 269930 109927139
Contraindicated product administered 296.61 9.74 266 391964 248001 109949068
Sleep disorder due to general medical condition, insomnia type 296.24 9.74 20 392210 105623 110091446
Arthropathy 292.85 9.74 353 391877 287169 109909900
Lip dry 289.52 9.74 16 392214 100067 110097002
Fibromyalgia 287.28 9.74 123 392107 170786 110026283
Completed suicide 282.08 9.74 266 391964 242115 109954954
Injury 281.75 9.74 138 392092 177127 110019942
Balance disorder 277.09 9.74 977 391253 115583 110081486
Alopecia 272.25 9.74 552 391678 364201 109832868
Blister 269.96 9.74 245 391985 227131 109969938
Low density lipoprotein increased 269.48 9.74 255 391975 10411 110186658
Cough 263.64 9.74 2648 389582 458993 109738076
Infection 257.85 9.74 563 391667 361637 109835432
Rheumatoid factor positive 237.28 9.74 85 392145 131555 110065514
Drug ineffective 235.73 9.74 3888 388342 1516652 108680417
Drug abuse 234.41 9.74 172 392058 177239 110019830
Blood calcium decreased 233.54 9.74 440 391790 35405 110161664
Blood pressure systolic increased 230.37 9.74 733 391497 82258 110114811
Live birth 230.29 9.74 3 392227 69481 110127588
Obstructive airways disorder 228.92 9.74 506 391724 45643 110151426
Blood glucose increased 226.98 9.74 1002 391228 131494 110065575
Swelling 224.85 9.74 577 391653 350464 109846605
Nasal oedema 223.32 9.74 189 392041 6650 110190419
Myocardial infarction 222.42 9.74 1301 390929 190782 110006287
Product use issue 218.93 9.74 488 391742 311207 109885862
Coronary artery disease 218.32 9.74 654 391576 71036 110126033
Immune-mediated myositis 214.52 9.74 177 392053 6009 110191060
Bursitis 211.25 9.74 98 392132 129820 110067249
Blood triglycerides increased 207.20 9.74 333 391897 23593 110173476
Peripheral venous disease 206.57 9.74 27 392203 84090 110112979
Drug interaction 204.93 9.74 2690 389540 497493 109699576
High density lipoprotein decreased 200.82 9.74 165 392065 5568 110191501
Cognitive disorder 200.67 9.74 725 391505 86786 110110283
General physical health deterioration 192.29 9.74 815 391415 424480 109772589
Joint range of motion decreased 191.83 9.74 96 392134 121736 110075333
Grip strength decreased 184.73 9.74 31 392199 80143 110116926
Psoriatic arthropathy 182.39 9.74 259 391971 196502 110000567
Euglycaemic diabetic ketoacidosis 178.07 9.74 213 392017 11410 110185659
Wound infection 177.79 9.74 60 392170 96405 110100664
Acute myocardial infarction 177.00 9.74 676 391554 83101 110113968
Toxicity to various agents 172.89 9.74 998 391232 479557 109717512
Low density lipoprotein decreased 171.53 9.74 89 392141 1333 110195736
Hypersensitivity 159.06 9.74 814 391416 403184 109793885
Pregnancy 158.21 9.74 5 392225 51062 110146007
Blepharospasm 157.93 9.74 9 392221 54842 110142227
Cardiac failure 155.43 9.74 1169 391061 186457 110010612
Chest discomfort 155.38 9.74 1103 391127 172745 110024324
Disease progression 154.74 9.74 403 391827 243631 109953438
Therapy non-responder 153.94 9.74 199 392031 157108 110039961
Reversible airways obstruction 151.20 9.74 100 392130 2399 110194670
Fall 150.49 9.74 2989 389241 600493 109596576
Lower respiratory tract infection 149.96 9.74 407 391823 242699 109954370
Lower limb fracture 149.45 9.74 41 392189 75307 110121762
Neutropenia 149.06 9.74 752 391478 373868 109823201
Night sweats 148.94 9.74 153 392077 133830 110063239
Inflammation 147.87 9.74 288 391942 192950 110004119
Productive cough 147.34 9.74 797 391433 113508 110083561
Dyslipidaemia 143.47 9.74 226 392004 15739 110181330
Dyspnoea 142.07 9.74 5022 387208 1101850 109095219
Adjustment disorder 138.48 9.74 181 392049 10614 110186455
Arterial occlusive disease 136.60 9.74 216 392014 15092 110181977
Atrial fibrillation 132.64 9.74 1321 390909 228321 109968748
Bronchiectasis 131.67 9.74 354 391876 36139 110160930
C-reactive protein abnormal 131.14 9.74 160 392070 129535 110067534
Asthenia 130.90 9.74 3283 388947 685716 109511353
Hepatic enzyme increased 128.86 9.74 642 391588 320250 109876819
Diabetic ketoacidosis 128.34 9.74 384 391846 41674 110155395
Myelosuppression 127.81 9.74 89 392141 94251 110102818
Cataract 127.77 9.74 590 391640 78895 110118174
Respiratory tract infection 127.48 9.74 548 391682 71069 110126000
Carotid artery thrombosis 127.38 9.74 164 392066 9474 110187595
Epilepsy 126.17 9.74 102 392128 100107 110096962
Intentional overdose 125.18 9.74 172 392058 132329 110064740
Cerebrovascular accident 124.89 9.74 1083 391147 180201 110016868
Onychomadesis 124.14 9.74 10 392220 45653 110151416
Condition aggravated 122.25 9.74 1852 390378 732984 109464085
Angina unstable 121.37 9.74 213 392017 16219 110180850
Obesity 120.89 9.74 134 392096 113217 110083852
X-ray abnormal 120.79 9.74 3 392227 38114 110158955
Coronary artery occlusion 119.82 9.74 207 392023 15565 110181504
Gangrene 119.63 9.74 211 392019 16130 110180939
Lactic acidosis 119.52 9.74 647 391583 92164 110104905
Neurologic neglect syndrome 119.43 9.74 156 392074 9142 110187927
Arteriosclerosis coronary artery 118.51 9.74 270 391960 24848 110172221
Palpitations 118.07 9.74 967 391263 158245 110038824
Product use in unapproved indication 117.76 9.74 1017 391213 446360 109750709
Muscle spasms 117.51 9.74 1505 390725 276652 109920417
Erectile dysfunction 117.43 9.74 225 392005 18331 110178738
Chronic kidney disease 117.28 9.74 559 391671 75732 110121337
Glycosylated haemoglobin increased 117.16 9.74 259 391971 23360 110173709
Autoimmune disorder 116.77 9.74 43 392187 65440 110131629
Nail disorder 115.89 9.74 31 392199 57904 110139165
Constipation 115.68 9.74 1847 390383 355939 109841130
Conjunctivitis allergic 114.46 9.74 132 392098 6799 110190270
Drug intolerance 114.30 9.74 908 391322 405604 109791465
Chromaturia 113.26 9.74 292 391938 29068 110168001
Prescribed overdose 111.70 9.74 88 392142 87493 110109576
Hypotension 110.28 9.74 2532 389698 521317 109675752
Coronary artery stenosis 109.04 9.74 184 392046 13574 110183495
Arteriosclerosis 108.93 9.74 259 391971 24508 110172561
Death 107.29 9.74 1788 390442 697081 109499988
Cardiac failure chronic 107.20 9.74 183 392047 13628 110183441
Pyrexia 106.29 9.74 2402 389828 895863 109301206
Road traffic accident 105.95 9.74 135 392095 107263 110089806
Coeliac disease 105.70 9.74 14 392216 43173 110153896
Rales 104.83 9.74 255 391975 24484 110172585
Diabetes mellitus inadequate control 104.59 9.74 286 391944 29489 110167580
Rheumatoid factor negative 103.74 9.74 62 392168 1238 110195831
Crush syndrome 102.23 9.74 42 392188 353 110196716
Autoimmune myositis 102.02 9.74 56 392174 945 110196124
Hemiplegia 101.02 9.74 239 391991 22543 110174526
Diabetes mellitus 99.77 9.74 649 391581 98732 110098337
Discomfort 99.06 9.74 408 391822 214299 109982770
Drug ineffective for unapproved indication 98.65 9.74 132 392098 102706 110094363
Muscular weakness 98.10 9.74 1328 390902 247140 109949929
Skin haemorrhage 97.92 9.74 249 391981 24578 110172491
Ill-defined disorder 97.90 9.74 261 391969 156592 110040477
Joint swelling 97.76 9.74 1051 391179 441794 109755275
Myositis 97.70 9.74 287 391943 30829 110166240
Blood creatinine increased 97.45 9.74 1035 391195 181854 110015215
Sedation 96.74 9.74 496 391734 69187 110127882
Pain in extremity 95.93 9.74 2333 389897 484785 109712284
Affect lability 95.43 9.74 207 392023 18430 110178639
Cystitis 93.74 9.74 473 391757 65563 110131506
Myoglobin blood increased 93.47 9.74 94 392136 4138 110192931
Chest pain 93.25 9.74 1863 390367 374512 109822557
Sinus congestion 92.84 9.74 278 391952 30181 110166888
Tendon rupture 91.93 9.74 173 392057 13905 110183164
Leukopenia 91.79 9.74 249 391981 148542 110048527
Product substitution issue 91.70 9.74 232 391998 22829 110174240
Coma 91.61 9.74 174 392056 117695 110079374
Multi-organ disorder 89.57 9.74 83 392147 3298 110193771
Wheezing 89.11 9.74 1335 390895 253895 109943174
Mite allergy 88.33 9.74 106 392124 5697 110191372
Overdose 86.95 9.74 480 391750 233314 109963755
Spirometry abnormal 86.29 9.74 102 392128 5395 110191674
Personality disorder 85.38 9.74 159 392071 12678 110184391
Mucosal inflammation 84.72 9.74 131 392099 96010 110101059
Transient ischaemic attack 84.39 9.74 449 391781 63533 110133536
Dyspnoea exertional 83.13 9.74 643 391587 103417 110093652
Mycotic allergy 82.93 9.74 104 392126 5850 110191219
Sleep disorder 82.84 9.74 392 391838 198252 109998817
Intentional product use issue 82.66 9.74 527 391703 247379 109949690
Vital capacity decreased 81.84 9.74 64 392166 2009 110195060
Ischaemic stroke 81.49 9.74 326 391904 40937 110156132
Sensory loss 81.32 9.74 212 392018 21245 110175824
Dust allergy 80.70 9.74 103 392127 5898 110191171
Glomerular filtration rate decreased 80.55 9.74 256 391974 28700 110168369
Cytomegalovirus infection 79.71 9.74 47 392183 54397 110142672
Muscle rupture 78.85 9.74 88 392142 4372 110192697
Abdominal discomfort 78.59 9.74 956 391274 392902 109804167
Thrombocytopenia 78.18 9.74 825 391405 348060 109849009
Device expulsion 78.08 9.74 9 392221 30882 110166187
Injection site reaction 77.88 9.74 122 392108 88948 110108121
Eosinophil count increased 77.71 9.74 206 392024 20852 110176217
Hyperkalaemia 76.83 9.74 778 391452 135018 110062051
Coordination abnormal 76.65 9.74 230 392000 24998 110172071
Onychomycosis 76.34 9.74 21 392209 38510 110158559
Myopathy toxic 75.31 9.74 51 392179 1274 110195795
Adverse event 74.17 9.74 173 392057 108636 110088433
Skin exfoliation 74.17 9.74 549 391681 87102 110109967
Abortion spontaneous 73.15 9.74 16 392214 34266 110162803
Intentional self-injury 73.04 9.74 21 392209 37408 110159661
Seizure 72.30 9.74 473 391757 220712 109976357
Back injury 72.15 9.74 39 392191 47360 110149709
Micturition urgency 71.30 9.74 189 392041 19131 110177938
Hepatic function abnormal 70.90 9.74 551 391679 88744 110108325
Alanine aminotransferase increased 70.79 9.74 978 391252 182795 110014274
Cerebral infarction 69.20 9.74 365 391865 51473 110145596
Sneezing 68.29 9.74 259 391971 31725 110165344
Tubulointerstitial nephritis 68.24 9.74 376 391854 53908 110143161
Premature delivery 68.05 9.74 13 392217 30619 110166450
Muscle disorder 67.79 9.74 100 392130 6572 110190497
Muscle necrosis 67.77 9.74 54 392176 1743 110195326
Pancytopenia 67.63 9.74 450 391780 209163 109987906
Sinus disorder 67.40 9.74 262 391968 32466 110164603
Renal failure 67.02 9.74 1153 391077 225421 109971648
Eating disorder 66.81 9.74 251 391979 30607 110166462
Acute coronary syndrome 66.75 9.74 207 392023 22905 110174164
Eye haemorrhage 66.35 9.74 136 392094 11638 110185431
Malignant melanoma in situ 66.28 9.74 72 392158 3470 110193599
Vertigo 66.20 9.74 531 391699 86339 110110730
Bone marrow failure 65.48 9.74 65 392165 57783 110139286
Congenital hiatus hernia 65.32 9.74 95 392135 6164 110190905
Blood pressure fluctuation 65.22 9.74 472 391758 74352 110122717
Weight decreased 64.58 9.74 2143 390087 465914 109731155
Needle fatigue 63.27 9.74 45 392185 1219 110195850
Toxic epidermal necrolysis 62.78 9.74 65 392165 56662 110140407
Vascular stent stenosis 62.09 9.74 48 392182 1481 110195588
Carotid artery stenosis 61.94 9.74 115 392115 9148 110187921
Drug resistance 61.93 9.74 65 392165 56309 110140760
Motor dysfunction 61.81 9.74 209 392021 24197 110172872
Normal newborn 61.80 9.74 4 392226 21892 110175177
Gait spastic 61.54 9.74 48 392182 1501 110195568
Transaminases increased 61.21 9.74 410 391820 62980 110134089
Suicide attempt 60.83 9.74 177 392053 103217 110093852
Necrotising myositis 60.64 9.74 53 392177 1949 110195120
Carotid arteriosclerosis 60.47 9.74 64 392166 2993 110194076
Sepsis 60.28 9.74 808 391422 326538 109870531
Normochromic normocytic anaemia 60.10 9.74 139 392091 12918 110184151
Gait inability 59.90 9.74 264 391966 136112 110060957
Hepatic cirrhosis 59.72 9.74 92 392138 67534 110129535
Thyroid disorder 59.60 9.74 163 392067 16806 110180263
Respiratory tract congestion 59.50 9.74 242 391988 30615 110166454
Urticaria 59.46 9.74 785 391445 318072 109878997
Rash 58.67 9.74 2349 389881 818615 109378454
Hip arthroplasty 58.39 9.74 67 392163 55746 110141323
Electrocardiogram Q wave abnormal 58.12 9.74 35 392195 709 110196360
Depressed level of consciousness 57.74 9.74 631 391599 111647 110085422
Metabolic acidosis 57.64 9.74 574 391656 99170 110097899
Haemophagocytic lymphohistiocytosis 57.50 9.74 20 392210 31539 110165530
Aphasia 57.21 9.74 382 391848 58615 110138454
Interstitial lung disease 57.14 9.74 750 391480 138584 110058485
Pulmonary mass 57.09 9.74 273 391957 37028 110160041
Troponin increased 57.05 9.74 233 391997 29533 110167536
Body temperature decreased 57.02 9.74 271 391959 36664 110160405
Lipoprotein (a) increased 56.78 9.74 20 392210 104 110196965
Human rhinovirus test positive 56.66 9.74 42 392188 1215 110195854
Blood mercury abnormal 56.47 9.74 25 392205 257 110196812
Lung diffusion test decreased 56.40 9.74 47 392183 1618 110195451
Mitral valve incompetence 56.23 9.74 251 391979 33078 110163991
Hepatojugular reflux 55.93 9.74 34 392196 701 110196368
Lupus-like syndrome 55.89 9.74 38 392192 40754 110156315
Burns second degree 55.51 9.74 99 392131 7634 110189435
Arthritis 55.16 9.74 868 391362 166718 110030351
Cerebral haemorrhage 55.00 9.74 407 391823 64561 110132508
Aspartate aminotransferase increased 54.79 9.74 834 391396 159102 110037967
Respiratory arrest 54.73 9.74 76 392154 58223 110138846
Sciatica 54.48 9.74 158 392072 92241 110104828
Multiple organ dysfunction syndrome 54.48 9.74 315 391915 151395 110045674
Graft versus host disease 54.40 9.74 3 392227 18803 110178266
Respiratory depression 53.79 9.74 23 392207 31978 110165091
Hyperglycaemia 53.77 9.74 499 391731 84591 110112478
Dermatomyositis 53.62 9.74 72 392158 4334 110192735
Malignant mediastinal neoplasm 53.23 9.74 42 392188 1336 110195733
Pollakiuria 52.82 9.74 302 391928 43893 110153176
Catarrh 52.78 9.74 94 392136 7241 110189828
Computerised tomogram coronary artery abnormal 52.56 9.74 20 392210 134 110196935
Thrombotic microangiopathy 52.21 9.74 19 392211 29130 110167939
Finger deformity 52.19 9.74 26 392204 33066 110164003
Psoriasis 51.88 9.74 740 391490 139253 110057816
Product quality issue 51.80 9.74 124 392106 77175 110119894
Diastolic dysfunction 51.64 9.74 127 392103 12277 110184792
Lipids increased 51.43 9.74 48 392182 1925 110195144
Rhinorrhoea 51.43 9.74 574 391656 102092 110094977
Septic shock 50.90 9.74 338 391892 157190 110039879
Pancreatitis acute 50.69 9.74 377 391853 59897 110137172
COVID-19 50.67 9.74 1182 391048 243878 109953191
Stenosis 50.66 9.74 61 392169 3290 110193779
Muscle discomfort 49.64 9.74 27 392203 447 110196622
Sputum culture positive 49.56 9.74 65 392165 3824 110193245
Muscle atrophy 49.25 9.74 130 392100 13124 110183945
Heart rate decreased 49.16 9.74 479 391751 82277 110114792
Myocardial ischaemia 48.88 9.74 206 392024 26478 110170591
Middle insomnia 48.81 9.74 172 392058 20330 110176739
Sinusitis 48.75 9.74 749 391481 295939 109901130
Incorrect route of product administration 48.52 9.74 96 392134 63965 110133104
C-reactive protein increased 48.50 9.74 516 391714 217403 109979666
Dry mouth 48.41 9.74 464 391766 199484 109997585
Ascites 48.20 9.74 168 392062 92640 110104429
Respiratory syncytial virus test positive 48.19 9.74 41 392189 1453 110195616
Blood pressure diastolic decreased 48.12 9.74 253 391977 35632 110161437
Nephritic syndrome 47.89 9.74 27 392203 481 110196588
Benign prostatic hyperplasia 47.82 9.74 158 392072 18076 110178993
Parosmia 47.69 9.74 128 392102 13052 110184017
Exercise tolerance decreased 47.56 9.74 121 392109 11946 110185123
Blood pressure systolic abnormal 47.21 9.74 194 392036 24656 110172413
Hypoglycaemia 47.21 9.74 624 391606 115480 110081589
Restrictive pulmonary disease 47.12 9.74 58 392172 3201 110193868
Dysgeusia 47.07 9.74 416 391814 69569 110127500
Contusion 47.05 9.74 565 391665 232796 109964273
Influenza like illness 46.44 9.74 499 391731 87913 110109156
Taste disorder 46.15 9.74 102 392128 65285 110131784
Posterior reversible encephalopathy syndrome 45.78 9.74 32 392198 33829 110163240
Ventricular extrasystoles 45.61 9.74 180 392050 22461 110174608
Relapsing-remitting multiple sclerosis 45.53 9.74 46 392184 2036 110195033
Vitamin B12 decreased 45.29 9.74 73 392157 5184 110191885
Knee arthroplasty 45.28 9.74 102 392128 64846 110132223
Blood immunoglobulin E increased 45.24 9.74 89 392141 7393 110189676
Eosinophilic granulomatosis with polyangiitis 45.11 9.74 110 392120 10576 110186493
Hypertonic bladder 44.82 9.74 73 392157 5229 110191840
Hypopnoea 44.74 9.74 114 392116 11266 110185803
Oedema 44.40 9.74 1016 391214 208960 109988109
Neutropenic sepsis 44.37 9.74 27 392203 30719 110166350
Loss of personal independence in daily activities 44.18 9.74 763 391467 149257 110047812
Poisoning deliberate 44.14 9.74 19 392211 26312 110170757
Syncope 44.08 9.74 984 391246 201552 109995517
Hepatocellular injury 43.87 9.74 319 391911 50323 110146746
Post transplant lymphoproliferative disorder 43.63 9.74 3 392227 15610 110181459
Amyotrophic lateral sclerosis 43.55 9.74 45 392185 2046 110195023
Steroid dependence 43.28 9.74 94 392136 8375 110188694
Poisoning 42.78 9.74 25 392205 29080 110167989
Polymyositis 42.71 9.74 59 392171 3649 110193420
Liver injury 42.66 9.74 335 391895 150078 110046991
Hemiparesis 42.41 9.74 284 391946 43619 110153450
Haematuria 41.99 9.74 465 391765 82540 110114529
Pulmonary valve disease 41.96 9.74 22 392208 337 110196732
Gingival pain 41.85 9.74 137 392093 15599 110181470
Dizziness 41.56 9.74 2942 389288 695251 109501818
Malignant neoplasm progression 41.45 9.74 407 391823 174160 110022909
Adverse reaction 41.31 9.74 27 392203 29567 110167502
Chronic obstructive pulmonary disease 41.24 9.74 579 391651 108579 110088490
Low cardiac output syndrome 41.21 9.74 33 392197 1073 110195996
Renal impairment 41.15 9.74 916 391314 187529 110009540
Viral test positive 41.07 9.74 30 392200 848 110196221
5-hydroxyindolacetic acid in urine increased 40.92 9.74 18 392212 182 110196887
Mental status changes 40.75 9.74 136 392094 75986 110121083
Creatinine renal clearance increased 40.74 9.74 57 392173 3568 110193501
Device related infection 40.74 9.74 48 392182 39471 110157598
Gastrointestinal disorder 40.71 9.74 608 391622 241344 109955725
Chronic sinusitis 40.64 9.74 19 392211 25065 110172004
Hyper IgE syndrome 40.59 9.74 27 392203 654 110196415
Haemorrhagic stroke 40.28 9.74 124 392106 13665 110183404
Laryngitis 40.10 9.74 55 392175 42356 110154713
Ulnar tunnel syndrome 40.07 9.74 10 392220 9 110197060
Neuritis 39.98 9.74 84 392146 7315 110189754
Neutrophil count decreased 39.82 9.74 258 391972 120683 110076386
Hyperthyroidism 39.72 9.74 207 392023 29054 110168015
Fractional exhaled nitric oxide increased 39.71 9.74 28 392202 748 110196321
Haemoptysis 39.48 9.74 407 391823 70947 110126122
Injection site scab 39.45 9.74 26 392204 620 110196449
Ejection fraction decreased 39.22 9.74 264 391966 40616 110156453
Coronary artery restenosis 39.04 9.74 33 392197 1159 110195910
Pancreatitis 38.99 9.74 505 391725 93028 110104041
Female genital tract fistula 38.92 9.74 6 392224 16513 110180556
Blood pressure diastolic abnormal 38.83 9.74 188 392042 25627 110171442
Occult blood 38.76 9.74 40 392190 1816 110195253
Cytomegalovirus viraemia 38.50 9.74 8 392222 17756 110179313
Pulmonary function test abnormal 38.47 9.74 66 392164 4934 110192135
Tachycardia 38.31 9.74 569 391661 226076 109970993
Cytomegalovirus infection reactivation 38.23 9.74 9 392221 18324 110178745
Bronchopulmonary aspergillosis 38.08 9.74 30 392200 29833 110167236
Lipids abnormal 38.06 9.74 26 392204 659 110196410
Blood cholesterol abnormal 37.85 9.74 56 392174 3690 110193379
Drug dependence 37.85 9.74 75 392155 49945 110147124
Transplant rejection 37.70 9.74 20 392210 24547 110172522
Aortic aneurysm 37.68 9.74 98 392132 9806 110187263
Low density lipoprotein abnormal 37.60 9.74 24 392206 541 110196528
Multiple allergies 37.44 9.74 112 392118 12151 110184918
Drug use disorder 37.44 9.74 9 392221 18065 110179004
Foetal death 37.41 9.74 6 392224 16039 110181030
Supine hypertension 37.27 9.74 22 392208 429 110196640
Respiratory disorder 37.21 9.74 129 392101 71253 110125816
Orbital myositis 37.15 9.74 18 392212 231 110196838
Blood pressure inadequately controlled 37.06 9.74 83 392147 7550 110189519
Lichen planopilaris 37.06 9.74 16 392214 154 110196915
Bronchial secretion retention 36.94 9.74 65 392165 4959 110192110
Type 2 diabetes mellitus 36.91 9.74 426 391804 176806 110020263
Forced vital capacity decreased 36.78 9.74 40 392190 1930 110195139
Neuroleptic malignant syndrome 36.60 9.74 40 392190 34019 110163050
Peripheral arterial occlusive disease 36.52 9.74 93 392137 9187 110187882
Hyperlipidaemia 36.51 9.74 235 391995 35613 110161456
Impaired quality of life 36.45 9.74 206 392024 29811 110167258
Pancreatitis necrotising 36.42 9.74 68 392162 5433 110191636
Appendicolith 36.41 9.74 4 392226 14251 110182818
Infusion site reaction 36.25 9.74 9 392221 17673 110179396
Aortic valve incompetence 36.12 9.74 103 392127 10878 110186191
Skin laceration 36.07 9.74 224 392006 33529 110163540
Loss of control of legs 35.87 9.74 41 392189 2091 110194978
Haematotoxicity 35.68 9.74 15 392215 21067 110176002
Helicobacter gastritis 35.33 9.74 45 392185 2571 110194498
Eosinophilia 35.23 9.74 337 391893 57599 110139470
Blood parathyroid hormone decreased 35.21 9.74 3 392227 13086 110183983
Upper-airway cough syndrome 35.17 9.74 130 392100 15727 110181342
Pulmonary alveolar haemorrhage 34.94 9.74 153 392077 19997 110177072
Tricuspid valve incompetence 34.58 9.74 172 392058 23701 110173368
Ear infection 34.32 9.74 111 392119 62621 110134448
Generalised tonic-clonic seizure 34.09 9.74 91 392139 54589 110142480
Status epilepticus 34.01 9.74 37 392193 31534 110165535
Cardiac murmur 33.96 9.74 175 392055 24453 110172616
Osteoarthritis 33.87 9.74 450 391780 182173 110014896
Skin necrosis 33.78 9.74 17 392213 21495 110175574
Musculoskeletal pain 33.58 9.74 452 391778 182571 110014498
Lipoprotein (a) decreased 33.55 9.74 11 392219 44 110197025
Malaise 33.34 9.74 2791 389439 669028 109528041
Dysarthria 33.32 9.74 450 391780 83671 110113398
Pancreatic neuroendocrine tumour 33.24 9.74 27 392203 896 110196173
Ageusia 33.18 9.74 148 392082 19497 110177572
Left ventricular hypertrophy 33.17 9.74 113 392117 13131 110183938
Therapy partial responder 33.13 9.74 50 392180 37011 110160058
Ventricular hypokinesia 32.90 9.74 101 392129 11113 110185956
Acute respiratory distress syndrome 32.82 9.74 89 392141 53109 110143960
White blood cell count decreased 32.79 9.74 594 391636 228796 109968273
N-terminal prohormone brain natriuretic peptide abnormal 32.73 9.74 18 392212 305 110196764
Pulmonary vasculitis 32.60 9.74 72 392158 6488 110190581
Lipase increased 32.55 9.74 142 392088 18530 110178539
Aspergillus infection 32.33 9.74 26 392204 25590 110171479
Rhinitis perennial 32.17 9.74 16 392214 218 110196851
Neoplasm progression 32.17 9.74 119 392111 64476 110132593
Vascular stent thrombosis 32.12 9.74 55 392175 4106 110192963
Total lung capacity decreased 31.94 9.74 75 392155 7039 110190030
Inappropriate schedule of product administration 31.89 9.74 947 391283 202690 109994379
Adverse drug reaction 31.87 9.74 231 391999 105328 110091741
Joint dislocation 31.66 9.74 45 392185 34145 110162924
Red blood cell sedimentation rate abnormal 31.63 9.74 171 392059 24338 110172731
Hepatic enzyme abnormal 31.56 9.74 91 392139 9672 110187397
Pneumocystis jirovecii pneumonia 31.55 9.74 65 392165 42670 110154399
Cytokine release syndrome 31.54 9.74 135 392095 70171 110126898
Aplastic anaemia 31.53 9.74 24 392206 24284 110172785
Bacterial infection 31.52 9.74 73 392157 45963 110151106
Vaginal discharge 31.52 9.74 12 392218 17896 110179173
Sputum discoloured 31.48 9.74 188 392042 27757 110169312
Withdrawal syndrome 31.41 9.74 39 392191 31341 110165728
Exostosis 31.37 9.74 73 392157 45883 110151186
Blood glucose abnormal 31.30 9.74 109 392121 12807 110184262
Burning sensation 31.11 9.74 379 391851 68833 110128236
Stent placement 31.11 9.74 75 392155 7159 110189910
Hepatic neoplasm 31.02 9.74 52 392178 3815 110193254
Somnolence 31.02 9.74 810 391420 296639 109900430
Pneumonia haemophilus 30.98 9.74 43 392187 2672 110194397
Muscle spasticity 30.97 9.74 226 392004 35689 110161380
Pathogen resistance 30.84 9.74 12 392218 17660 110179409
Miosis 30.76 9.74 20 392210 21963 110175106
Delirium 30.73 9.74 318 391912 134707 110062362
Ketoacidosis 30.68 9.74 92 392138 9995 110187074
Drug withdrawal syndrome 30.60 9.74 55 392175 37999 110159070
Drug-disease interaction 30.52 9.74 36 392194 1900 110195169
Caesarean section 30.41 9.74 6 392224 13811 110183258
Respiratory failure 30.03 9.74 560 391670 214772 109982297
Pericardial disease 30.02 9.74 23 392207 700 110196369
Eczema 29.99 9.74 390 391840 71903 110125166
Renal tubular necrosis 29.95 9.74 198 392032 30277 110166792
Prescribed underdose 29.94 9.74 124 392106 65050 110132019
Lung disorder 29.74 9.74 454 391776 179593 110017476
Bundle branch block left 29.72 9.74 107 392123 12781 110184288
Temperature regulation disorder 29.45 9.74 5 392225 12821 110184248
Amyloid related imaging abnormality-oedema/effusion 29.44 9.74 32 392198 1543 110195526
Drug tolerance 29.38 9.74 11 392219 16574 110180495
Nightmare 29.30 9.74 237 391993 38626 110158443
Inspiratory capacity abnormal 29.19 9.74 12 392218 101 110196968
Vascular device infection 29.17 9.74 11 392219 16501 110180568
Intensive care 29.14 9.74 39 392191 2340 110194729
Colitis microscopic 29.04 9.74 109 392121 13285 110183784
Rhinitis 28.90 9.74 157 392073 22388 110174681
No adverse event 28.87 9.74 149 392081 73690 110123379
Urine albumin/creatinine ratio increased 28.86 9.74 27 392203 1086 110195983
Immunodeficiency 28.73 9.74 59 392171 38779 110158290
Nipple inflammation 28.71 9.74 10 392220 50 110197019
Nocturia 28.70 9.74 128 392102 16862 110180207
Multiple-drug resistance 28.60 9.74 6 392224 13229 110183840
Goitre 28.50 9.74 66 392164 6138 110190931
Candida infection 28.37 9.74 82 392148 47927 110149142
Dermatitis allergic 28.33 9.74 152 392078 21572 110175497
Gait disturbance 28.31 9.74 1232 390998 276976 109920093
Left ventricular enlargement 28.29 9.74 24 392206 847 110196222
Oral candidiasis 28.28 9.74 74 392156 44686 110152383
Musculoskeletal discomfort 28.23 9.74 161 392069 23377 110173692
Anuria 28.22 9.74 165 392065 24176 110172893
Musculoskeletal stiffness 28.13 9.74 766 391464 279056 109918013
Red blood cell sedimentation rate increased 27.88 9.74 163 392067 78139 110118930
Enterococcal infection 27.86 9.74 19 392211 20347 110176722
Tinnitus 27.86 9.74 333 391897 60207 110136862
Blood test abnormal 27.75 9.74 185 392045 28369 110168700
Rheumatoid nodule 27.68 9.74 19 392211 20277 110176792
Autoimmune hepatitis 27.67 9.74 115 392115 14689 110182380
Needle issue 27.61 9.74 131 392099 17709 110179360
Brain natriuretic peptide increased 27.52 9.74 95 392135 11114 110185955
Serotonin syndrome 27.52 9.74 112 392118 59041 110138028
Clostridium test positive 27.33 9.74 93 392137 10800 110186269
Mydriasis 27.33 9.74 23 392207 22134 110174935
Androgenetic alopecia 27.28 9.74 15 392215 254 110196815
Flatulence 27.23 9.74 294 391936 51855 110145214
Potentiating drug interaction 27.14 9.74 97 392133 11546 110185523
Tumour lysis syndrome 27.10 9.74 42 392188 30759 110166310
Carcinoid tumour 27.09 9.74 20 392210 575 110196494
Drug tolerance decreased 26.76 9.74 35 392195 27505 110169564
Blood thyroid stimulating hormone abnormal 26.64 9.74 26 392204 1103 110195966
Physical examination abnormal 26.64 9.74 19 392211 517 110196552
Musculoskeletal toxicity 26.39 9.74 14 392216 220 110196849
Restenosis 25.95 9.74 7 392223 11 110197058
Amblyopia 25.89 9.74 15 392215 282 110196787
Supraventricular extrasystoles 25.86 9.74 75 392155 7998 110189071
Angiocardiogram 25.80 9.74 15 392215 284 110196785
Renal function test abnormal 25.72 9.74 80 392150 8866 110188203
Blood cholesterol increased 25.62 9.74 481 391749 184304 110012765
Guillain-Barre syndrome 25.46 9.74 90 392140 10654 110186415
Cystitis haemorrhagic 25.45 9.74 6 392224 12203 110184866
Influenza 25.29 9.74 782 391448 168319 110028750
Albuminuria 25.21 9.74 24 392206 987 110196082
Blood triglycerides abnormal 25.04 9.74 19 392211 570 110196499
Progressive multifocal leukoencephalopathy 24.99 9.74 31 392199 24925 110172144
Total bile acids increased 24.87 9.74 10 392220 79 110196990
Drug-induced liver injury 24.76 9.74 579 391651 119488 110077581
Blood urine present 24.73 9.74 159 392071 24086 110172983
Mucormycosis 24.72 9.74 4 392226 10624 110186445
Migraine 24.68 9.74 444 391786 171208 110025861
Antineutrophil cytoplasmic antibody positive 24.43 9.74 55 392175 5021 110192048
BK virus infection 24.41 9.74 8 392222 13098 110183971
Hypoaesthesia 24.36 9.74 890 391340 313333 109883736
Back pain 24.26 9.74 1576 390654 369420 109827649
Haematocrit increased 24.17 9.74 54 392176 4905 110192164
Hepatic steatosis 23.99 9.74 272 391958 48559 110148510
Radiculopathy 23.94 9.74 20 392210 19316 110177753
Bronchopulmonary aspergillosis allergic 23.90 9.74 75 392155 8351 110188718
Breast pain 23.90 9.74 84 392146 9916 110187153
Dystonia 23.86 9.74 34 392196 25771 110171298
Ulcer 23.79 9.74 76 392154 43040 110154029
Pemphigoid 23.77 9.74 135 392095 19572 110177497
Hypothyroidism 23.75 9.74 377 391853 72522 110124547
Intentional product misuse 23.74 9.74 330 391900 132574 110064495
Systolic dysfunction 23.71 9.74 50 392180 4365 110192704
Very low density lipoprotein increased 23.54 9.74 15 392215 337 110196732
Hepatic encephalopathy 23.48 9.74 40 392190 28216 110168853
Blood pressure abnormal 23.45 9.74 148 392082 22276 110174793
Dyspnoea at rest 23.41 9.74 74 392156 8272 110188797
Blood calcium increased 23.37 9.74 126 392104 17914 110179155
Job change 23.26 9.74 6 392224 7 110197062
Brain oedema 23.21 9.74 47 392183 31051 110166018
Hernia 23.14 9.74 133 392097 19367 110177702
Xanthoma 23.09 9.74 13 392217 231 110196838
Pulmonary haemorrhage 22.99 9.74 15 392215 16441 110180628
Haemoglobin increased 22.87 9.74 78 392152 9069 110188000
Confusional state 22.83 9.74 1395 390835 467285 109729784
Forced expiratory volume decreased 22.81 9.74 100 392130 13076 110183993
Microalbuminuria 22.69 9.74 25 392205 1224 110195845
Monoparesis 22.66 9.74 50 392180 4503 110192566
Presyncope 22.54 9.74 269 391961 48618 110148451
Cardiac disorder 22.46 9.74 388 391842 75892 110121177
Methaemoglobinaemia 22.37 9.74 3 392227 9165 110187904
Intermittent claudication 22.35 9.74 44 392186 3657 110193412
Haemorrhage subcutaneous 22.31 9.74 56 392174 5483 110191586
Dermatitis artefacta 22.29 9.74 9 392221 72 110196997
Dyspepsia 22.08 9.74 512 391718 190453 110006616
Unresponsive to stimuli 22.07 9.74 134 392096 63656 110133413
Platelet distribution width increased 22.05 9.74 11 392219 151 110196918
Panniculitis 22.04 9.74 14 392216 15568 110181501
Diabetic metabolic decompensation 22.01 9.74 45 392185 3844 110193225
Cardio-respiratory arrest 22.00 9.74 284 391946 115552 110081517
Reaction to preservatives 21.96 9.74 13 392217 255 110196814
Peripheral swelling 21.95 9.74 1190 391040 402844 109794225
Giant cell arteritis 21.95 9.74 44 392186 3705 110193364
Blood creatine increased 21.93 9.74 90 392140 11431 110185638
Acute myeloid leukaemia 21.86 9.74 66 392164 38044 110159025
Parkinsonism 21.76 9.74 28 392202 22159 110174910
Head injury 21.76 9.74 241 391989 42776 110154293
Cardiac discomfort 21.60 9.74 26 392204 1402 110195667
Eructation 21.60 9.74 103 392127 13954 110183115
Psychomotor hyperactivity 21.58 9.74 24 392206 20253 110176816
Tongue biting 21.58 9.74 38 392192 2901 110194168
Diabetic foot 21.56 9.74 46 392184 4049 110193020
Oropharyngeal discomfort 21.53 9.74 83 392147 10244 110186825
Mycobacterium test positive 21.52 9.74 18 392212 623 110196446
Gamma-glutamyltransferase increased 21.49 9.74 321 391909 60988 110136081
Photosensitivity reaction 21.48 9.74 160 392070 25429 110171640
Diverticulitis 21.48 9.74 287 391943 53235 110143834
Lung opacity 21.38 9.74 90 392140 11562 110185507
Febrile neutropenia 21.34 9.74 912 391318 315855 109881214
Sinus pain 21.17 9.74 57 392173 5822 110191247
Total cholesterol/HDL ratio increased 21.13 9.74 15 392215 405 110196664
Immune reconstitution inflammatory syndrome 21.07 9.74 16 392214 16210 110180859
High density lipoprotein increased 21.01 9.74 26 392204 1443 110195626
Pustular psoriasis 20.99 9.74 11 392219 13594 110183475
Prostatic specific antigen increased 20.94 9.74 94 392136 12417 110184652
Left ventricular dysfunction 20.93 9.74 149 392081 23344 110173725
Arrhythmia 20.89 9.74 355 391875 69220 110127849
Head discomfort 20.88 9.74 127 392103 18873 110178196
Deprescribing error 20.85 9.74 8 392222 55 110197014
Atrial enlargement 20.85 9.74 23 392207 1128 110195941
5-hydroxyindolacetic acid increased 20.80 9.74 10 392220 126 110196943
Weight increased 20.80 9.74 1247 390983 418397 109778672
Mean platelet volume increased 20.74 9.74 27 392203 1577 110195492
Nephrolithiasis 20.67 9.74 340 391890 65872 110131197
Degenerative bone disease 20.67 9.74 11 392219 174 110196895
Creutzfeldt-Jakob disease 20.56 9.74 12 392218 229 110196840
Right atrial enlargement 20.52 9.74 16 392214 500 110196569
Confabulation 20.39 9.74 16 392214 505 110196564
Muscle hypoxia 20.30 9.74 5 392225 4 110197065
Aggression 20.16 9.74 125 392105 59085 110137984
Epstein-Barr virus infection 20.14 9.74 22 392208 18716 110178353
Glomerular filtration rate 20.13 9.74 11 392219 184 110196885
Anastomotic infection 20.13 9.74 10 392220 136 110196933
Left ventricular dilatation 20.06 9.74 25 392205 1397 110195672
Alopecia scarring 20.02 9.74 11 392219 186 110196883
Urine ketone body present 20.01 9.74 43 392187 3803 110193266
Extrasystoles 19.99 9.74 70 392160 8248 110188821
Haematochezia 19.95 9.74 544 391686 114980 110082089
Klebsiella infection 19.89 9.74 25 392205 19984 110177085
Movement disorder 19.83 9.74 207 392023 36197 110160872
Pericardial effusion 19.83 9.74 299 391931 56918 110140151
Helicobacter test false negative 19.81 9.74 8 392222 64 110197005
Ventricular hyperkinesia 19.80 9.74 13 392217 308 110196761
Pseudomonal sepsis 19.76 9.74 4 392226 9042 110188027
Brain natriuretic peptide abnormal 19.75 9.74 20 392210 888 110196181
Rheumatic disorder 19.67 9.74 41 392189 3550 110193519
Myoglobinuria 19.63 9.74 23 392207 1205 110195864
Blood thyroid stimulating hormone increased 19.53 9.74 91 392139 12210 110184859
Growth hormone deficiency 19.43 9.74 15 392215 462 110196607
Prostatomegaly 19.35 9.74 45 392185 4197 110192872
Substance abuse 19.34 9.74 10 392220 12453 110184616
Cholestasis 19.30 9.74 329 391901 64189 110132880
Paraplegia 19.28 9.74 57 392173 6143 110190926
Lipoma 19.20 9.74 43 392187 3912 110193157
Fractured coccyx 19.18 9.74 23 392207 1235 110195834
Endocrine ophthalmopathy 19.15 9.74 24 392206 1349 110195720
General symptom 19.14 9.74 4 392226 8842 110188227
Disease risk factor 19.13 9.74 12 392218 262 110196807
Pseudohallucination 19.12 9.74 11 392219 204 110196865
Osteoporosis 19.12 9.74 207 392023 86945 110110124
Discontinued product administered 19.03 9.74 9 392221 109 110196960
Hypogammaglobulinaemia 19.01 9.74 26 392204 20050 110177019
Liver function test abnormal 18.98 9.74 347 391883 68603 110128466
Skin toxicity 18.97 9.74 9 392221 11774 110185295
Decubitus ulcer 18.96 9.74 22 392208 18214 110178855
Plantar fasciitis 18.92 9.74 50 392180 5051 110192018
High density lipoprotein abnormal 18.89 9.74 11 392219 209 110196860
Polymyalgia rheumatica 18.88 9.74 58 392172 6384 110190685
Prinzmetal angina 18.86 9.74 31 392199 2238 110194831
Essential hypertension 18.82 9.74 66 392164 7781 110189288
Encephalopathy 18.81 9.74 190 392040 80865 110116204
Staphylococcal infection 18.81 9.74 158 392072 69786 110127283
Myelodysplastic syndrome 18.70 9.74 69 392161 37415 110159654
Electrocardiogram abnormal 18.66 9.74 122 392108 18587 110178482
Nodular melanoma 18.62 9.74 12 392218 275 110196794
Granulocytopenia 18.58 9.74 11 392219 12704 110184365
Ventricular arrhythmia 18.57 9.74 78 392152 10009 110187060
Listless 18.55 9.74 46 392184 4469 110192600
Total cholesterol/HDL ratio abnormal 18.53 9.74 8 392222 77 110196992
Transaminases abnormal 18.34 9.74 20 392210 968 110196101
Product residue present 18.19 9.74 42 392188 3899 110193170
Vasculitis 18.16 9.74 201 392029 35672 110161397
Eye irritation 18.12 9.74 190 392040 33262 110163807
Blood creatine phosphokinase abnormal 18.00 9.74 17 392213 692 110196377
Gynaecomastia 17.96 9.74 74 392156 9416 110187653
Blood urea increased 17.83 9.74 284 391946 54673 110142396
Renal cyst 17.82 9.74 118 392112 18054 110179015
Dermatitis atopic 17.78 9.74 153 392077 25388 110171681
Diabetic neuropathy 17.78 9.74 60 392170 6939 110190130
Hypomania 17.71 9.74 7 392223 10203 110186866
Type V hyperlipidaemia 17.70 9.74 24 392206 1458 110195611
Left atrial enlargement 17.67 9.74 26 392204 1705 110195364
Plasmapheresis 17.65 9.74 18 392212 806 110196263
Sputum culture 17.64 9.74 12 392218 302 110196767
Device issue 17.60 9.74 63 392167 34472 110162597
Exposure to toxic agent 17.58 9.74 12 392218 12846 110184223
Hypokinesia 17.50 9.74 135 392095 21691 110175378
Abnormal behaviour 17.48 9.74 75 392155 38964 110158105
Therapeutic response decreased 17.45 9.74 239 391991 96260 110100809
Gastrooesophageal reflux disease 17.42 9.74 793 391437 179183 110017886
Procedural pain 17.39 9.74 66 392164 35499 110161570
Serum procollagen type I N-terminal propeptide increased 17.39 9.74 6 392224 29 110197040
Blood pressure diastolic increased 17.18 9.74 120 392110 18687 110178382
Polyomavirus-associated nephropathy 17.15 9.74 4 392226 8197 110188872
Right ventricular failure 17.10 9.74 42 392188 25912 110171157
Procollagen type I C-terminal propeptide increased 17.07 9.74 6 392224 31 110197038
Proctitis 16.98 9.74 21 392209 16906 110180163
Ulcer haemorrhage 16.94 9.74 34 392196 22537 110174532
Blood immunoglobulin G increased 16.94 9.74 40 392190 3768 110193301
Normocytic anaemia 16.92 9.74 56 392174 6411 110190658
Hepatitis E antibody positive 16.85 9.74 11 392219 258 110196811
Hepatitis C 16.84 9.74 12 392218 12561 110184508
Malignant melanoma 16.76 9.74 110 392120 16781 110180288
Blood creatine phosphokinase 16.68 9.74 12 392218 331 110196738
Hypomagnesaemia 16.68 9.74 304 391926 60066 110137003
Total cholesterol/HDL ratio decreased 16.62 9.74 7 392223 63 110197006
Amylase increased 16.60 9.74 88 392142 12431 110184638
Nodule 16.59 9.74 183 392047 32448 110164621
Bradycardia 16.55 9.74 692 391538 154825 110042244
Left atrial dilatation 16.50 9.74 38 392192 3522 110193547
Renal colic 16.47 9.74 36 392194 3222 110193847
Non-alcoholic steatohepatitis 16.43 9.74 31 392199 2496 110194573
Rebound effect 16.34 9.74 17 392213 14789 110182280
Diffuse alopecia 16.34 9.74 22 392208 1328 110195741
Cardiovascular somatic symptom disorder 16.32 9.74 6 392224 36 110197033
Joint stiffness 16.28 9.74 156 392074 67087 110129982
Encephalitis 16.28 9.74 26 392204 18813 110178256
Eyelid disorder 16.26 9.74 30 392200 2375 110194694
Proteinuria 16.23 9.74 215 392015 39803 110157266
Asthmatic crisis 16.12 9.74 28 392202 2114 110194955
Plasma cell myeloma 16.11 9.74 144 392086 62792 110134277
Degenerative aortic valve disease 16.04 9.74 10 392220 216 110196853
Peripheral sensorimotor neuropathy 16.02 9.74 40 392190 3903 110193166
Cytopenia 15.98 9.74 54 392176 30062 110167007
Macular degeneration 15.94 9.74 33 392197 21626 110175443
Memory impairment 15.90 9.74 555 391675 196389 110000680
Cardiac autonomic neuropathy 15.89 9.74 7 392223 71 110196998
Blood loss anaemia 15.87 9.74 114 392116 17911 110179158
Blood immunoglobulin M increased 15.87 9.74 24 392206 1613 110195456
Gastrointestinal toxicity 15.79 9.74 10 392220 11138 110185931
Metastases to central nervous system 15.77 9.74 36 392194 22781 110174288
Acute hepatic failure 15.76 9.74 71 392159 36397 110160672
Coagulopathy 15.74 9.74 83 392147 40828 110156241
Blood creatine phosphokinase MB increased 15.73 9.74 33 392197 2870 110194199
FEV1/FVC ratio decreased 15.69 9.74 11 392219 291 110196778
Tryptase increased 15.64 9.74 18 392212 925 110196144
Salmonella bacteraemia 15.64 9.74 15 392215 623 110196446
Medication error 15.63 9.74 271 391959 105095 110091974
Oesophageal irritation 15.59 9.74 11 392219 294 110196775
Endometriosis 15.59 9.74 42 392188 4292 110192777
Urinary casts present 15.59 9.74 8 392222 117 110196952
Blood pressure ambulatory increased 15.56 9.74 7 392223 75 110196994
Atrial thrombosis 15.52 9.74 42 392188 4304 110192765
Tendonitis 15.50 9.74 151 392079 25932 110171137
Hepatitis E virus test positive 15.50 9.74 11 392219 297 110196772
Neurotoxicity 15.49 9.74 87 392143 42120 110154949
Device related sepsis 15.47 9.74 4 392226 7643 110189426
Ureteric cancer 15.47 9.74 11 392219 298 110196771
Skin irritation 15.42 9.74 105 392125 16214 110180855
Melanoderma 15.37 9.74 13 392217 457 110196612
Mouth haemorrhage 15.36 9.74 91 392139 13397 110183672
Anaemia 15.35 9.74 1702 390528 545384 109651685
Sinonasal obstruction 15.34 9.74 12 392218 377 110196692
Meningitis eosinophilic 15.25 9.74 5 392225 20 110197049
Melaena 15.24 9.74 335 391895 68422 110128647
Gastroduodenal ulcer 15.21 9.74 18 392212 953 110196116
Thalamus haemorrhage 15.21 9.74 26 392204 1938 110195131
Lymphopenia 15.18 9.74 82 392148 40088 110156981
Underdose 15.15 9.74 148 392082 63406 110133663
Cerebral haematoma 15.11 9.74 71 392159 9561 110187508
Expired product administered 15.06 9.74 64 392166 8256 110188813
Paradoxical drug reaction 15.05 9.74 8 392222 9809 110187260
Lacrimation increased 15.02 9.74 172 392058 30778 110166291
Immobilisation syndrome 15 9.74 17 392213 859 110196210
Tendon pain 15.00 9.74 53 392177 6273 110190796
Ligament pain 14.97 9.74 10 392220 244 110196825
Retro-orbital neoplasm 14.93 9.74 7 392223 83 110196986
Chronic spontaneous urticaria 14.93 9.74 26 392204 1967 110195102
Muscle contractions involuntary 14.93 9.74 42 392188 4402 110192667
Hereditary haemorrhagic telangiectasia 14.86 9.74 7 392223 84 110196985
Blood pressure decreased 14.83 9.74 523 391707 114568 110082501
Dry skin 14.83 9.74 493 391737 107160 110089909
Palmar-plantar erythrodysaesthesia syndrome 14.82 9.74 85 392145 40940 110156129
Unwanted awareness during anaesthesia 14.81 9.74 12 392218 397 110196672
Multiple drug therapy 14.78 9.74 62 392168 7952 110189117
Premature labour 14.78 9.74 7 392223 9165 110187904
Abortion induced 14.75 9.74 5 392225 8014 110189055
Small fibre neuropathy 14.74 9.74 18 392212 985 110196084
Infusion site streaking 14.70 9.74 14 392216 576 110196493
Arcus lipoides 14.69 9.74 5 392225 23 110197046
Breast cancer stage I 14.68 9.74 4 392226 7383 110189686
Varicella zoster pneumonia 14.68 9.74 12 392218 402 110196667
Swollen tongue 14.65 9.74 298 391932 60064 110137005
Nodular rash 14.64 9.74 11 392219 325 110196744
Idiopathic pulmonary fibrosis 14.62 9.74 45 392185 4959 110192110
Craniofacial fracture 14.61 9.74 17 392213 884 110196185
Breath sounds abnormal 14.58 9.74 146 392084 25258 110171811
Apolipoprotein A-I decreased 14.52 9.74 5 392225 24 110197045
Injection site hypersensitivity 14.47 9.74 29 392201 2442 110194627
Overlap syndrome 14.46 9.74 7 392223 9052 110188017
Vitamin D deficiency 14.46 9.74 114 392116 18438 110178631
Urine viscosity increased 14.44 9.74 6 392224 52 110197017
Dehydration 14.43 9.74 1165 391065 278346 109918723
Cardiac arrest 14.41 9.74 561 391669 196192 110000877
Prostatic haemorrhage 14.41 9.74 9 392221 195 110196874
Toxic shock syndrome 14.33 9.74 22 392208 1498 110195571
Mast cell activation syndrome 14.24 9.74 22 392208 1506 110195563
Tendon disorder 14.22 9.74 63 392167 8274 110188795
Red cell distribution width increased 14.18 9.74 109 392121 17493 110179576
Sopor 14.14 9.74 74 392156 36472 110160597
Large intestine polyp 14.13 9.74 97 392133 15020 110182049
Total lung capacity abnormal 14.13 9.74 42 392188 4541 110192528
Pseudomonas infection 14.07 9.74 51 392179 27802 110169267
Basophil count increased 14.07 9.74 24 392206 1786 110195283
Pertussis 14.04 9.74 20 392210 1273 110195796
Abscess of salivary gland 14.04 9.74 5 392225 27 110197042
Depressed mood 14.03 9.74 298 391932 60511 110136558
Walking disability 14.01 9.74 29 392201 2499 110194570
Hypercholesterolaemia 14.01 9.74 232 391998 90605 110106464
Ear pain 13.97 9.74 121 392109 53105 110143964
Musculoskeletal foreign body 13.94 9.74 3 392227 0 110197069
Basophil percentage decreased 13.94 9.74 3 392227 0 110197069
Pseudocellulitis 13.92 9.74 12 392218 433 110196636
Apathy 13.89 9.74 102 392128 16137 110180932
Tongue injury 13.89 9.74 14 392216 618 110196451
Extrapyramidal disorder 13.84 9.74 54 392176 28813 110168256
Alcohol poisoning 13.79 9.74 66 392164 8954 110188115
Haemorrhagic diathesis 13.78 9.74 58 392172 7450 110189619
Graft versus host disease in skin 13.77 9.74 6 392224 8248 110188821
Heart rate increased 13.75 9.74 633 391597 143201 110053868
Upper gastrointestinal haemorrhage 13.75 9.74 252 391978 49844 110147225
Disease recurrence 13.75 9.74 297 391933 60487 110136582
Blood cholesterol decreased 13.71 9.74 30 392200 2686 110194383
Oedema genital 13.70 9.74 14 392216 628 110196441
Cataract operation 13.70 9.74 49 392181 5834 110191235
Decreased ventricular preload 13.70 9.74 6 392224 60 110197009
Hypereosinophilic syndrome 13.66 9.74 16 392214 838 110196231
Granuloma annulare 13.64 9.74 16 392214 839 110196230
Nasal polyps 13.64 9.74 16 392214 13184 110183885
Oncologic complication 13.58 9.74 12 392218 448 110196621
Coronary arterial stent insertion 13.55 9.74 49 392181 5866 110191203
Rotator cuff syndrome 13.53 9.74 104 392126 16690 110180379
Ventricular tachycardia 13.53 9.74 251 391979 49758 110147311
Rheumatoid arthritis 13.51 9.74 898 391332 298715 109898354
Hepatic mass 13.50 9.74 31 392199 2867 110194202
Tendon injury 13.46 9.74 28 392202 2421 110194648
Breast swelling 13.45 9.74 22 392208 1582 110195487
Retroperitoneal fibrosis 13.44 9.74 15 392215 745 110196324
Organic erectile dysfunction 13.42 9.74 7 392223 106 110196963
Neoplasm 13.40 9.74 76 392154 11011 110186058
Pneumonia cytomegaloviral 13.39 9.74 4 392226 6950 110190119
Aldolase increased 13.39 9.74 9 392221 222 110196847
Febrile bone marrow aplasia 13.37 9.74 26 392204 17439 110179630
Bradypnoea 13.33 9.74 7 392223 8642 110188427
Peripheral artery restenosis 13.33 9.74 4 392226 11 110197058
Clitoris abscess 13.33 9.74 4 392226 11 110197058
Oxygen saturation increased 13.31 9.74 15 392215 753 110196316
Mitral valve thickening 13.30 9.74 15 392215 754 110196315
Walking aid user 13.28 9.74 45 392185 25030 110172039
Hyperlipasaemia 13.27 9.74 21 392209 1468 110195601
Blood bicarbonate decreased 13.26 9.74 48 392182 5749 110191320
Pulmonary tuberculosis 13.22 9.74 8 392222 9131 110187938
Subdural haematoma 13.22 9.74 192 392038 36262 110160807
Haemorrhagic cerebral infarction 13.21 9.74 21 392209 1474 110195595
Aortic valve sclerosis 13.20 9.74 24 392206 1879 110195190
Arterial spasm 13.16 9.74 8 392222 165 110196904
Aortic disorder 13.15 9.74 18 392212 1104 110195965
Mitral valve disease 13.14 9.74 34 392196 3391 110193678
Intercapillary glomerulosclerosis 13.08 9.74 7 392223 112 110196957
Complications of transplanted kidney 13.08 9.74 5 392225 7437 110189632
Renal phospholipidosis 13.00 9.74 11 392219 387 110196682
B-lymphocyte abnormalities 12.99 9.74 8 392222 169 110196900
Oesophageal carcinoma 12.98 9.74 13 392217 11511 110185558
Kidney transplant rejection 12.97 9.74 14 392216 11973 110185096
Chronic cutaneous lupus erythematosus 12.94 9.74 17 392213 1002 110196067
Therapeutic product effect incomplete 12.93 9.74 655 391575 223150 109973919
Base excess decreased 12.85 9.74 11 392219 393 110196676
Endometrial disorder 12.83 9.74 14 392216 678 110196391
Phonophobia 12.82 9.74 14 392216 679 110196390
Optic neuropathy 12.79 9.74 41 392189 4617 110192452
Conjunctivitis 12.76 9.74 69 392161 33723 110163346
Gastric ulcer haemorrhage 12.74 9.74 70 392160 10024 110187045
Angiopathy 12.72 9.74 63 392167 8667 110188402
Swelling of eyelid 12.69 9.74 52 392178 6601 110190468
Dysphonia 12.67 9.74 356 391874 75573 110121496
Mania 12.67 9.74 35 392195 20761 110176308
Fungaemia 12.67 9.74 3 392227 6083 110190986
Muscle fatigue 12.62 9.74 37 392193 3970 110193099
Electrocardiogram ambulatory abnormal 12.60 9.74 5 392225 38 110197031
Lymphomatoid papulosis 12.60 9.74 11 392219 404 110196665
Suicidal ideation 12.56 9.74 246 391984 93691 110103378
Subcutaneous haematoma 12.55 9.74 31 392199 3005 110194064
Agitation 12.54 9.74 305 391925 112746 110084323
Sensorimotor disorder 12.54 9.74 18 392212 1154 110195915
Spondylitis 12.53 9.74 13 392217 11325 110185744
Nasal discharge discolouration 12.51 9.74 32 392198 3169 110193900
Hypercreatinaemia 12.48 9.74 11 392219 409 110196660
Testicular pain 12.46 9.74 27 392203 2402 110194667
Polyp 12.46 9.74 69 392161 9911 110187158
Impaired work ability 12.46 9.74 146 392084 26273 110170796
Metastases to liver 12.42 9.74 74 392156 35312 110161757
Maternal condition affecting foetus 12.39 9.74 8 392222 184 110196885
Blood creatine phosphokinase MM increased 12.38 9.74 5 392225 40 110197029
Foreign body in throat 12.37 9.74 17 392213 1046 110196023
Blood chloride increased 12.31 9.74 50 392180 6322 110190747
Autonomic neuropathy 12.30 9.74 26 392204 2274 110194795
Food interaction 12.29 9.74 25 392205 2127 110194942
Anion gap abnormal 12.28 9.74 15 392215 821 110196248
Diabetic retinopathy 12.28 9.74 34 392196 3530 110193539
Immobile 12.24 9.74 57 392173 7645 110189424
Lichen planus 12.22 9.74 33 392197 3377 110193692
Episcleral venous pressure increased 12.20 9.74 4 392226 16 110197053
Erythema marginatum 12.20 9.74 4 392226 16 110197053
Suspected suicide 12.19 9.74 22 392208 15177 110181892
Occupational exposure to dust 12.17 9.74 5 392225 42 110197027
Oxygen consumption decreased 12.16 9.74 12 392218 516 110196553
Adrenocortical insufficiency acute 12.12 9.74 39 392191 4401 110192668
Infrequent bowel movements 12.11 9.74 25 392205 2150 110194919
Hospitalisation 12.09 9.74 399 391831 142094 110054975
Complication associated with device 12.07 9.74 34 392196 20039 110177030
Faeces discoloured 11.99 9.74 178 392052 33770 110163299
Cytomegalovirus colitis 11.99 9.74 5 392225 7056 110190013
Oedema mouth 11.94 9.74 31 392199 3099 110193970
Secretion discharge 11.93 9.74 117 392113 20127 110176942
Pre-eclampsia 11.93 9.74 8 392222 8642 110188427
Sleep disorder due to a general medical condition 11.90 9.74 255 391975 51857 110145212
Hypertriglyceridaemia 11.90 9.74 98 392132 16056 110181013
Diffuse large B-cell lymphoma 11.89 9.74 24 392206 15874 110181195
Metastases to bone 11.88 9.74 64 392166 31308 110165761
Nail discolouration 11.86 9.74 34 392196 3601 110193468
Carnitine palmitoyltransferase deficiency 11.83 9.74 4 392226 18 110197051
Cardiac flutter 11.78 9.74 46 392184 5711 110191358
Acute lymphocytic leukaemia recurrent 11.76 9.74 3 392227 5784 110191285
Device use error 11.75 9.74 9 392221 9080 110187989
Blood lactate dehydrogenase abnormal 11.74 9.74 13 392217 640 110196429
Sinus tachycardia 11.74 9.74 101 392129 44392 110152677
Pseudomembranous colitis 11.73 9.74 4 392226 6387 110190682
Balanoposthitis 11.71 9.74 19 392211 1357 110195712
Urine glucose/creatinine ratio increased 11.70 9.74 7 392223 140 110196929
Psychiatric decompensation 11.69 9.74 3 392227 5762 110191307
Acute lymphocytic leukaemia 11.69 9.74 3 392227 5762 110191307
Neurological symptom 11.67 9.74 95 392135 15513 110181556
Primary myelofibrosis 11.64 9.74 8 392222 205 110196864
Diabetic nephropathy 11.63 9.74 33 392197 3475 110193594
Histamine level increased 11.61 9.74 7 392223 142 110196927
Cardiomegaly 11.60 9.74 156 392074 28974 110168095
Tardive dyskinesia 11.49 9.74 19 392211 13560 110183509
Stress 11.49 9.74 470 391760 104878 110092191
Toxic cataract 11.49 9.74 4 392226 20 110197049
Coma acidotic 11.44 9.74 7 392223 146 110196923
Electrocardiogram QRS complex abnormal 11.44 9.74 14 392216 768 110196301
Fluid retention 11.42 9.74 251 391979 94056 110103013
Angioplasty 11.38 9.74 23 392207 1948 110195121
Oedema peripheral 11.38 9.74 1332 390898 327328 109869741
Osteonecrosis of jaw 11.37 9.74 112 392118 47905 110149164
Atheroembolism 11.37 9.74 10 392220 371 110196698
Vertebrobasilar insufficiency 11.37 9.74 10 392220 371 110196698
Renal artery stenosis 11.35 9.74 34 392196 3692 110193377
Coronary artery bypass 11.34 9.74 47 392183 5995 110191074
Intervertebral disc protrusion 11.31 9.74 149 392081 27549 110169520
Injection site erythema 11.31 9.74 251 391979 93925 110103144
Thrombotic cerebral infarction 11.27 9.74 14 392216 780 110196289
Eye disorder 11.18 9.74 154 392076 28752 110168317
Psychotic disorder 11.16 9.74 121 392109 50816 110146253
Myoglobin urine present 11.14 9.74 15 392215 905 110196164
Escherichia infection 11.13 9.74 45 392185 23771 110173298
Sinus rhythm 11.13 9.74 16 392214 1027 110196042
Restless legs syndrome 11.13 9.74 135 392095 24491 110172578
Nipple disorder 11.10 9.74 10 392220 383 110196686
Serum ferritin increased 11.06 9.74 76 392154 11771 110185298
Troponin T increased 11.01 9.74 37 392193 4269 110192800
Heparin-induced thrombocytopenia test 10.99 9.74 8 392222 225 110196844
Hyperplastic cholecystopathy 10.99 9.74 8 392222 225 110196844
Occipital neuralgia 10.95 9.74 13 392217 691 110196378
Arterial stent insertion 10.94 9.74 6 392224 101 110196968
Sleep apnoea syndrome 10.94 9.74 203 392027 40244 110156825
Respiratory distress 10.92 9.74 175 392055 68699 110128370
Urinary retention 10.88 9.74 324 391906 69359 110127710
Amenorrhoea 10.88 9.74 10 392220 9221 110187848
Blood triglycerides decreased 10.87 9.74 8 392222 229 110196840
Increased upper airway secretion 10.87 9.74 42 392188 5190 110191879
Meningitis aseptic 10.86 9.74 66 392164 9804 110187265
Cardiac aneurysm 10.85 9.74 21 392209 1724 110195345
Aortic valve stenosis 10.85 9.74 48 392182 6302 110190767
Hypochromasia 10.83 9.74 13 392217 699 110196370
Body temperature increased 10.81 9.74 133 392097 54580 110142489
Tonsillitis 10.79 9.74 8 392222 8205 110188864
Herpes simplex 10.79 9.74 25 392205 15739 110181330
Mesenteric artery thrombosis 10.73 9.74 15 392215 938 110196131
Pulmonary arterial pressure abnormal 10.73 9.74 15 392215 938 110196131
Prohormone brain natriuretic peptide increased 10.72 9.74 10 392220 401 110196668
Body mass index decreased 10.70 9.74 14 392216 822 110196247
Foot deformity 10.69 9.74 115 392115 48365 110148704
Urethral injury 10.69 9.74 5 392225 59 110197010
Myelodysplastic syndrome unclassifiable 10.69 9.74 6 392224 106 110196963
Fatigue 10.68 9.74 4618 387612 1211340 108985729
Gastrointestinal malformation 10.66 9.74 3 392227 6 110197063
Thyroglossal cyst 10.66 9.74 3 392227 6 110197063
Violence-related symptom 10.66 9.74 15 392215 944 110196125
Respiratory symptom 10.65 9.74 90 392140 14855 110182214
Infected dermal cyst 10.64 9.74 18 392212 1330 110195739
Intracranial pressure increased 10.64 9.74 13 392217 10522 110186547
Spinal flattening 10.60 9.74 8 392222 238 110196831
Haemolysis 10.55 9.74 25 392205 15614 110181455
Urine odour abnormal 10.44 9.74 53 392177 7362 110189707
Epicondylitis 10.43 9.74 26 392204 2534 110194535
Hepatotoxicity 10.42 9.74 160 392070 63240 110133829
Streptococcal infection 10.42 9.74 14 392216 10876 110186193
Renal pain 10.40 9.74 65 392165 9752 110187317
Contraindication to surgery 10.35 9.74 3 392227 7 110197062
Mononeuropathy multiplex 10.35 9.74 14 392216 849 110196220
Burning feet syndrome 10.34 9.74 8 392222 247 110196822
Oxygen saturation decreased 10.27 9.74 667 391563 156315 110040754
Venous oxygen saturation decreased 10.26 9.74 5 392225 65 110197004
Hepatitis B reactivation 10.21 9.74 7 392223 7477 110189592
Hyperhidrosis 10.21 9.74 784 391446 186514 110010555
Infective spondylitis 10.18 9.74 11 392219 527 110196542
Post streptococcal glomerulonephritis 10.16 9.74 6 392224 117 110196952
Prostatism 10.16 9.74 6 392224 117 110196952
Pancreatic neoplasm 10.16 9.74 21 392209 1808 110195261
Ingrowing nail 10.16 9.74 30 392200 3232 110193837
Wound dehiscence 10.15 9.74 8 392222 7954 110189115
Breast discomfort 10.14 9.74 11 392219 529 110196540
Vaginal haemorrhage 10.14 9.74 50 392180 25024 110172045
Arrhythmia supraventricular 10.14 9.74 25 392205 2421 110194648
Cardiac failure congestive 10.14 9.74 643 391587 150357 110046712
Glucose urine present 10.13 9.74 24 392206 2265 110194804
Device breakage 10.11 9.74 21 392209 13748 110183321
Dissociation 10.09 9.74 12 392218 9830 110187239
Chronic gastritis 10.09 9.74 42 392188 5369 110191700
Abdominal pain lower 10.04 9.74 187 392043 37096 110159973
Paraesthesia 10.03 9.74 844 391386 275677 109921392
Transcription medication error 10.00 9.74 12 392218 645 110196424
Skin test negative 9.93 9.74 5 392225 70 110196999
Complication of device insertion 9.92 9.74 10 392220 8828 110188241
Aortic valve calcification 9.91 9.74 14 392216 884 110196185
Lung neoplasm malignant 9.91 9.74 172 392058 33670 110163399
Acute pulmonary oedema 9.91 9.74 98 392132 16898 110180171
Reduced facial expression 9.90 9.74 32 392198 3619 110193450
Forced vital capacity abnormal 9.87 9.74 5 392225 71 110196998
Allergic eosinophilia 9.87 9.74 5 392225 71 110196998
Intercepted product preparation error 9.82 9.74 6 392224 6814 110190255
Oropharyngeal pain 9.82 9.74 580 391650 134696 110062373
Myotonic dystrophy 9.77 9.74 7 392223 192 110196877
Ischaemic cardiomyopathy 9.74 9.74 55 392175 7956 110189113

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BH52 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
ATC C10AA07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX10 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX13 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX14 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX16 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX17 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX20 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX21 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX22 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX23 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX24 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D057847 Lipid Regulating Agents
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35679 antilipemic drug
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:49205 CETP inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77307 cardioprotective agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:64951 anti-HBV agent

Related Drugs by ATC class:

A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors 9 drugs
alogliptinevogliptingemigliptinlinagliptinsaxagliptinsimvastatinsitagliptinteneligliptinvildagliptin
C10AA HMG CoA reductase inhibitors 7 drugs
atorvastatincerivastatinfluvastatinlovastatinpitavastatinpravastatinsimvastatin
C10BA Combinations of various lipid modifying agents 9 drugs
atorvastatinbempedoic acidezetimibefenofibratelovastatinnicotinic acidpitavastatinpravastatinsimvastatin
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Prevention of Transient Ischemic Attacks indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Alcoholism contraindication 7200002
Proteinuria contraindication 29738008 DOID:576
Dehydration contraindication 34095006
Blood in urine contraindication 34436003
Hypothyroidism contraindication 40930008 DOID:1459
Acute nephropathy contraindication 58574008
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.29 acidic
pKa2 13.84 acidic
pKa3 3.67 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 10MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 10376470 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 10MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 9763885 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 20MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 10376470 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 20MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 9763885 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 40MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 10376470 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 40MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 9763885 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 5MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 10376470 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA
10MG;EQ 5MG BASE ROSZET ALTHERA PHARMS N213072 March 23, 2021 DISCN TABLET ORAL 9763885 May 1, 2033 TREATMENT OF HYPERLIPIDEMIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR Ki 9.05 CHEMBL CHEMBL
Phosphodiesterase 6D Enzyme Kd 5.90 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.68 CHEMBL

External reference:

IDSource
4021405 VUID
N0000148821 NUI
D01915 KEGG_DRUG
147098-20-2 SECONDARY_CAS_RN
4021405 VANDF
C0965129 UMLSCUI
CHEBI:38545 CHEBI
FBI PDB_CHEM_ID
CHEMBL1496 ChEMBL_ID
CHEMBL1744447 ChEMBL_ID
D000068718 MESH_DESCRIPTOR_UI
DB01098 DRUGBANK_ID
2954 IUPHAR_LIGAND_ID
8021 INN_ID
413KH5ZJ73 UNII
446157 PUBCHEM_CID
301542 RXNORM
107656 MMSL
17146 MMSL
17536 MMSL
34243 MMSL
46321 MMSL
d04851 MMSL
009902 NDDF
009903 NDDF
019242 NDDF
1217216007 SNOMEDCT_US
406435003 SNOMEDCT_US
700067006 SNOMEDCT_US
768151007 SNOMEDCT_US
953412-08-3 SECONDARY_CAS_RN
413KH5ZJ73 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Crestor HUMAN PRESCRIPTION DRUG LABEL 1 0310-7560 TABLET, FILM COATED 5 mg ORAL NDA 27 sections
Crestor HUMAN PRESCRIPTION DRUG LABEL 1 0310-7570 TABLET, FILM COATED 10 mg ORAL NDA 27 sections
Crestor HUMAN PRESCRIPTION DRUG LABEL 1 0310-7580 TABLET, FILM COATED 20 mg ORAL NDA 27 sections
Crestor HUMAN PRESCRIPTION DRUG LABEL 1 0310-7590 TABLET, FILM COATED 40 mg ORAL NDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8532 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8533 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8534 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8535 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 11788-130 TABLET, COATED 5 mg ORAL ANDA 25 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 11788-131 TABLET, COATED 10 mg ORAL ANDA 25 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 11788-132 TABLET, COATED 20 mg ORAL ANDA 25 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 11788-133 TABLET, COATED 40 mg ORAL ANDA 25 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-179 TABLET, COATED 5 mg ORAL ANDA 21 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-180 TABLET, COATED 10 mg ORAL ANDA 21 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-181 TABLET, COATED 20 mg ORAL ANDA 21 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-182 TABLET, COATED 40 mg ORAL ANDA 21 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-720 TABLET 5 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-721 TABLET 10 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-722 TABLET 20 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 13668-723 TABLET 40 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 16714-988 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 16714-989 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 16714-990 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Rosuvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 16714-991 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-284 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-285 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-286 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-287 TABLET, FILM COATED 40 mg ORAL ANDA 28 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0183 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Rosuvastatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0186 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections