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| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 2340 | 85441-61-8 |
| Dose | Unit | Route |
|---|---|---|
| 15 | mg | O |
| 15 | mg | P |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
| S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 3.10 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.61 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.509 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 6.397 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 3.451 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 14.125 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 4.100 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 6.180 | % | High | 1 |
| herg | hERG pIC50 | 4.284 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 38.019 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 41.783 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 4.990 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SYK,TEK,TGFBR1 | 27 | |||
| kinase-selectivity-class | AXL,BRAF,EPHB4,GRK2,MAP2K6,PDK4 | 6 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 2.393 | Moderate | 0.69 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.862 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 51.642 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 3.890 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 9.268 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.66 | |
| pppb | Pig plasma protein binding (% unbound) | 7.170 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.008 | % | Moderate | 0.69 |
| rh-clint | Rat hepatocyte intrinsic clearance | 115.080 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 68.980 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 3.190 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 931.108 | uM | High | 1 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 19, 1991 | FDA | PFIZER PHARMS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Creatinine renal clearance decreased | 1370.63 | 22.09 | 350 | 12214 | 18549 | 90597334 |
| Sedation complication | 1363.42 | 22.09 | 341 | 12223 | 16603 | 90599280 |
| Orthostatic hypotension | 1356.97 | 22.09 | 412 | 12152 | 41415 | 90574468 |
| Sedation | 1229.37 | 22.09 | 395 | 12169 | 47776 | 90568107 |
| Blood calcium decreased | 1208.31 | 22.09 | 350 | 12214 | 29832 | 90586051 |
| Cognitive disorder | 1155.80 | 22.09 | 413 | 12151 | 68994 | 90546889 |
| Balance disorder | 1034.78 | 22.09 | 417 | 12147 | 96663 | 90519220 |
| Depressed level of consciousness | 913.12 | 22.09 | 352 | 12212 | 72432 | 90543451 |
| Constipation | 641.26 | 22.09 | 427 | 12137 | 279968 | 90335915 |
| Hypotension | 588.31 | 22.09 | 429 | 12135 | 324968 | 90290915 |
| Fall | 578.84 | 22.09 | 499 | 12065 | 481311 | 90134572 |
| Toxicity to various agents | 480.35 | 22.09 | 362 | 12202 | 287484 | 90328399 |
| Mobility decreased | 476.18 | 22.09 | 341 | 12223 | 250393 | 90365490 |
| Creatinine renal clearance increased | 171.52 | 22.09 | 47 | 12517 | 3234 | 90612649 |
| Renal function test abnormal | 154.73 | 22.09 | 52 | 12512 | 7139 | 90608744 |
| Pain | 151.30 | 22.09 | 386 | 12178 | 995955 | 89619928 |
| Multiple drug therapy | 144.17 | 22.09 | 49 | 12515 | 6960 | 90608923 |
| Heart sounds | 117.05 | 22.09 | 28 | 12536 | 1116 | 90614767 |
| Prolonged expiration | 114.43 | 22.09 | 28 | 12536 | 1229 | 90614654 |
| Depressive symptom | 78.44 | 22.09 | 29 | 12535 | 5256 | 90610627 |
| Respiration abnormal | 66.92 | 22.09 | 29 | 12535 | 7934 | 90607949 |
| Hypertensive emergency | 63.83 | 22.09 | 20 | 12544 | 2197 | 90613686 |
| Appetite disorder | 63.11 | 22.09 | 29 | 12535 | 9104 | 90606779 |
| Cardiac failure congestive | 48.52 | 22.09 | 64 | 12500 | 98630 | 90517253 |
| Rales | 45.52 | 22.09 | 28 | 12536 | 15799 | 90600084 |
| Flank pain | 45.33 | 22.09 | 30 | 12534 | 19192 | 90596691 |
| Angina pectoris | 39.48 | 22.09 | 37 | 12527 | 39123 | 90576760 |
| Myocardial infarction | 39.20 | 22.09 | 60 | 12504 | 105912 | 90509971 |
| Drug ineffective | 38.15 | 22.09 | 85 | 12479 | 1384213 | 89231670 |
| Drug abuse | 36.82 | 22.09 | 51 | 12513 | 82296 | 90533587 |
| Arthropathy | 34.27 | 22.09 | 5 | 12559 | 366237 | 90249646 |
| Synovitis | 32.04 | 22.09 | 4 | 12560 | 329748 | 90286135 |
| Rash | 31 | 22.09 | 39 | 12525 | 796061 | 89819822 |
| Bladder disorder | 30.83 | 22.09 | 19 | 12545 | 10753 | 90605130 |
| Dementia | 28.89 | 22.09 | 25 | 12539 | 23836 | 90592047 |
| Hepatic enzyme increased | 27.42 | 22.09 | 8 | 12556 | 360728 | 90255155 |
| Glossodynia | 26.63 | 22.09 | 6 | 12558 | 321773 | 90294110 |
| Therapeutic product effect decreased | 25.47 | 22.09 | 4 | 12560 | 277567 | 90338316 |
| Alopecia | 25.33 | 22.09 | 19 | 12545 | 495052 | 90120831 |
| Hypersensitivity | 25.18 | 22.09 | 16 | 12548 | 454661 | 90161222 |
| Discomfort | 25.07 | 22.09 | 4 | 12560 | 274331 | 90341552 |
| General physical health deterioration | 25.00 | 22.09 | 9 | 12555 | 355106 | 90260777 |
| Decreased activity | 24.86 | 22.09 | 15 | 12549 | 8177 | 90607706 |
| Drug interaction | 23.57 | 22.09 | 88 | 12476 | 276365 | 90339518 |
| Cerebrovascular accident | 22.93 | 22.09 | 52 | 12512 | 123481 | 90492402 |
| Exposure during pregnancy | 22.89 | 22.09 | 3 | 12561 | 238407 | 90377476 |
| Overdose | 22.49 | 22.09 | 60 | 12504 | 157649 | 90458234 |
| Impaired healing | 22.36 | 22.09 | 3 | 12561 | 234196 | 90381687 |
| Productive cough | 22.22 | 22.09 | 39 | 12525 | 77024 | 90538859 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood mercury abnormal | 139.56 | 18.51 | 25 | 5226 | 257 | 42615827 |
| Low density lipoprotein decreased | 101.40 | 18.51 | 25 | 5226 | 1279 | 42614805 |
| Expired product administered | 92.66 | 18.51 | 30 | 5221 | 4133 | 42611951 |
| Hepatic neoplasm | 88.54 | 18.51 | 25 | 5226 | 2166 | 42613918 |
| 5-hydroxyindolacetic acid in urine increased | 87.83 | 18.51 | 16 | 5235 | 182 | 42615902 |
| Cardiac failure congestive | 71.48 | 18.51 | 69 | 5182 | 85533 | 42530551 |
| Head titubation | 68.47 | 18.51 | 15 | 5236 | 454 | 42615630 |
| Neoplasm | 66.12 | 18.51 | 26 | 5225 | 6279 | 42609805 |
| Glycosylated haemoglobin increased | 56.83 | 18.51 | 29 | 5222 | 12895 | 42603189 |
| Myocardial infarction | 56.77 | 18.51 | 73 | 5178 | 123936 | 42492148 |
| 5-hydroxyindolacetic acid increased | 48.95 | 18.51 | 9 | 5242 | 108 | 42615976 |
| Cogwheel rigidity | 48.45 | 18.51 | 15 | 5236 | 1786 | 42614298 |
| Blood glucose increased | 48.01 | 18.51 | 52 | 5199 | 73647 | 42542437 |
| Arteriosclerosis coronary artery | 46.85 | 18.51 | 29 | 5222 | 18648 | 42597436 |
| Blood follicle stimulating hormone increased | 43.12 | 18.51 | 9 | 5242 | 215 | 42615869 |
| Hypertensive emergency | 40.00 | 18.51 | 12 | 5239 | 1285 | 42614799 |
| Blood potassium decreased | 39.69 | 18.51 | 27 | 5224 | 20357 | 42595727 |
| Fibrous histiocytoma | 38.97 | 18.51 | 9 | 5242 | 347 | 42615737 |
| Angioedema | 36.83 | 18.51 | 35 | 5216 | 42442 | 42573642 |
| Haematocrit decreased | 36.60 | 18.51 | 32 | 5219 | 34876 | 42581208 |
| Renal phospholipidosis | 34.31 | 18.51 | 7 | 5244 | 149 | 42615935 |
| Sedation complication | 34.01 | 18.51 | 13 | 5238 | 2906 | 42613178 |
| Gamma-glutamyltransferase increased | 32.49 | 18.51 | 29 | 5222 | 32468 | 42583616 |
| Blood pressure systolic increased | 30.04 | 18.51 | 26 | 5225 | 27942 | 42588142 |
| Acute myocardial infarction | 29.36 | 18.51 | 36 | 5215 | 58129 | 42557955 |
| Red blood cell count decreased | 28.43 | 18.51 | 27 | 5224 | 32688 | 42583396 |
| Urticaria | 28.34 | 18.51 | 40 | 5211 | 73996 | 42542088 |
| Coronary artery disease | 28.33 | 18.51 | 34 | 5217 | 53686 | 42562398 |
| Extrapyramidal disorder | 25.62 | 18.51 | 19 | 5232 | 16393 | 42599691 |
| Syncope | 24.62 | 18.51 | 44 | 5207 | 99362 | 42516722 |
| Rhabdomyolysis | 23.92 | 18.51 | 38 | 5213 | 77981 | 42538103 |
| Pseudohyponatraemia | 23.40 | 18.51 | 5 | 5246 | 134 | 42615950 |
| Bronchomalacia | 22.46 | 18.51 | 5 | 5246 | 163 | 42615921 |
| Cardiopulmonary failure | 22.01 | 18.51 | 11 | 5240 | 4672 | 42611412 |
| Anticholinergic syndrome | 21.88 | 18.51 | 8 | 5243 | 1581 | 42614503 |
| Paralysis | 20.44 | 18.51 | 12 | 5239 | 7008 | 42609076 |
| Aspartate aminotransferase increased | 20.19 | 18.51 | 35 | 5216 | 77128 | 42538956 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sedation complication | 1387.55 | 18.53 | 362 | 16002 | 19493 | 110553442 |
| Creatinine renal clearance decreased | 1330.08 | 18.53 | 357 | 16007 | 21458 | 110551477 |
| Orthostatic hypotension | 1169.39 | 18.53 | 419 | 15945 | 65830 | 110507105 |
| Blood calcium decreased | 1167.53 | 18.53 | 360 | 16004 | 35485 | 110537450 |
| Sedation | 1081.97 | 18.53 | 401 | 15963 | 69282 | 110503653 |
| Cognitive disorder | 1062.84 | 18.53 | 421 | 15943 | 87090 | 110485845 |
| Balance disorder | 956.03 | 18.53 | 424 | 15940 | 116136 | 110456799 |
| Depressed level of consciousness | 767.56 | 18.53 | 360 | 16004 | 111918 | 110461017 |
| Constipation | 530.13 | 18.53 | 431 | 15933 | 357355 | 110215580 |
| Mobility decreased | 525.52 | 18.53 | 364 | 16000 | 237058 | 110335877 |
| Fall | 493.00 | 18.53 | 521 | 15843 | 602961 | 109969974 |
| Hypotension | 461.18 | 18.53 | 471 | 15893 | 523378 | 110049557 |
| Toxicity to various agents | 337.73 | 18.53 | 384 | 15980 | 480171 | 110092764 |
| Pain | 170.29 | 18.53 | 410 | 15954 | 954545 | 109618390 |
| Creatinine renal clearance increased | 163.84 | 18.53 | 47 | 16317 | 3578 | 110569357 |
| Renal function test abnormal | 140.28 | 18.53 | 52 | 16312 | 8894 | 110564041 |
| Blood mercury abnormal | 134.95 | 18.53 | 25 | 16339 | 257 | 110572678 |
| Multiple drug therapy | 134.60 | 18.53 | 49 | 16315 | 7965 | 110564970 |
| Heart sounds | 115.25 | 18.53 | 28 | 16336 | 1115 | 110571820 |
| Cardiac failure congestive | 107.74 | 18.53 | 122 | 16242 | 150878 | 110422057 |
| Prolonged expiration | 106.75 | 18.53 | 28 | 16336 | 1524 | 110571411 |
| Hypertensive emergency | 97.72 | 18.53 | 31 | 16333 | 3320 | 110569615 |
| Low density lipoprotein decreased | 94.67 | 18.53 | 25 | 16339 | 1397 | 110571538 |
| Myocardial infarction | 87.37 | 18.53 | 124 | 16240 | 191959 | 110380976 |
| 5-hydroxyindolacetic acid in urine increased | 84.72 | 18.53 | 16 | 16348 | 184 | 110572751 |
| Expired product administered | 73.51 | 18.53 | 32 | 16332 | 8288 | 110564647 |
| Hepatic neoplasm | 70.02 | 18.53 | 25 | 16339 | 3842 | 110569093 |
| Depressive symptom | 63.57 | 18.53 | 29 | 16335 | 8385 | 110564550 |
| Respiration abnormal | 62.34 | 18.53 | 30 | 16334 | 9779 | 110563156 |
| Appetite disorder | 59.44 | 18.53 | 29 | 16335 | 9740 | 110563195 |
| 5-hydroxyindolacetic acid increased | 45.95 | 18.53 | 9 | 16355 | 127 | 110572808 |
| Neoplasm | 44.75 | 18.53 | 25 | 16339 | 11062 | 110561873 |
| Angina pectoris | 43.81 | 18.53 | 50 | 16314 | 62245 | 110510690 |
| Glycosylated haemoglobin increased | 42.38 | 18.53 | 32 | 16332 | 23587 | 110549348 |
| Flank pain | 40.76 | 18.53 | 31 | 16333 | 23099 | 110549836 |
| Coronary artery disease | 39.74 | 18.53 | 51 | 16313 | 71639 | 110501296 |
| Arteriosclerosis coronary artery | 38.50 | 18.53 | 31 | 16333 | 25087 | 110547848 |
| Bladder disorder | 36.67 | 18.53 | 22 | 16342 | 11115 | 110561820 |
| Blood follicle stimulating hormone increased | 36.04 | 18.53 | 9 | 16355 | 402 | 110572533 |
| Rales | 34.70 | 18.53 | 29 | 16335 | 24710 | 110548225 |
| Neutropenia | 34.02 | 18.53 | 7 | 16357 | 374613 | 110198322 |
| Drug ineffective | 33.19 | 18.53 | 115 | 16249 | 1520425 | 109052510 |
| General physical health deterioration | 32.83 | 18.53 | 11 | 16353 | 425284 | 110147651 |
| Blood glucose increased | 32.58 | 18.53 | 65 | 16299 | 132431 | 110440504 |
| Off label use | 32.37 | 18.53 | 114 | 16250 | 1500071 | 109072864 |
| Angioedema | 31.35 | 18.53 | 54 | 16310 | 98446 | 110474489 |
| Fibrous histiocytoma | 29.68 | 18.53 | 9 | 16355 | 830 | 110572105 |
| Head titubation | 29.28 | 18.53 | 10 | 16354 | 1347 | 110571588 |
| Cerebrovascular accident | 27.98 | 18.53 | 74 | 16290 | 181210 | 110391725 |
| Synovitis | 27.33 | 18.53 | 4 | 16360 | 274088 | 110298847 |
| Arthropathy | 26.88 | 18.53 | 5 | 16359 | 287517 | 110285418 |
| Renal phospholipidosis | 26.51 | 18.53 | 7 | 16357 | 391 | 110572544 |
| Acute myocardial infarction | 25.45 | 18.53 | 45 | 16319 | 83732 | 110489203 |
| Red blood cell count decreased | 24.83 | 18.53 | 39 | 16325 | 65884 | 110507051 |
| Blood potassium decreased | 24.65 | 18.53 | 35 | 16329 | 54079 | 110518856 |
| Condition aggravated | 24.16 | 18.53 | 45 | 16319 | 734791 | 109838144 |
| Rash | 23.84 | 18.53 | 54 | 16310 | 820910 | 109752025 |
| Dementia | 23.25 | 18.53 | 26 | 16338 | 31647 | 110541288 |
| Febrile neutropenia | 23.06 | 18.53 | 9 | 16355 | 316758 | 110256177 |
| Infection | 22.23 | 18.53 | 13 | 16351 | 362187 | 110210748 |
| Haematocrit decreased | 22.03 | 18.53 | 37 | 16327 | 66080 | 110506855 |
| Depressed mood | 21.56 | 18.53 | 35 | 16329 | 60774 | 110512161 |
| Allergy to arthropod bite | 21.17 | 18.53 | 6 | 16358 | 437 | 110572498 |
| Systemic lupus erythematosus | 20.65 | 18.53 | 6 | 16358 | 254332 | 110318603 |
| Pseudohyponatraemia | 20.48 | 18.53 | 5 | 16359 | 203 | 110572732 |
| Decreased activity | 19.98 | 18.53 | 15 | 16349 | 10959 | 110561976 |
| Cogwheel rigidity | 19.61 | 18.53 | 10 | 16354 | 3688 | 110569247 |
| Hepatic enzyme increased | 19.02 | 18.53 | 12 | 16352 | 320880 | 110252055 |
None
| Source | Code | Description |
|---|---|---|
| ATC | C09AA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| ATC | C09BA06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
| FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
| FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| CHEBI has role | CHEBI:35457 | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:50266 | prodrug |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Chronic heart failure | indication | 48447003 | |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Diabetic renal disease | off-label use | 127013003 | |
| Acute scleroderma renal crisis | off-label use | 236503001 | |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Nondiabetic Proteinuric Nephropathy | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Hypovolemia | contraindication | 28560003 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Immunosuppression | contraindication | 38013005 | |
| Angioedema | contraindication | 41291007 | DOID:1558 |
| Hypokalemia | contraindication | 43339004 | |
| Low blood pressure | contraindication | 45007003 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Azotemia | contraindication | 445009001 | |
| Hemodialysis with High-Flux Membrane | contraindication |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.96 | acidic |
| pKa2 | 5.72 | Basic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.08 | CHEMBL | CHEMBL | |||
| Angiotensin-converting enzyme | Enzyme | IC50 | 5.40 | DRUG MATRIX |
| ID | Source |
|---|---|
| 4020549 | VUID |
| N0000148256 | NUI |
| D00459 | KEGG_DRUG |
| 82586-55-8 | SECONDARY_CAS_RN |
| 4020379 | VANDF |
| 4020549 | VANDF |
| C0072857 | UMLSCUI |
| CHEBI:8713 | CHEBI |
| CHEMBL1592 | ChEMBL_ID |
| CHEMBL1201011 | ChEMBL_ID |
| D000077583 | MESH_DESCRIPTOR_UI |
| DB00881 | DRUGBANK_ID |
| 6350 | IUPHAR_LIGAND_ID |
| 5780 | INN_ID |
| RJ84Y44811 | UNII |
| 54892 | PUBCHEM_CID |
| DB14217 | DRUGBANK_ID |
| 1546359 | RXNORM |
| 5401 | MMSL |
| 63990 | MMSL |
| d00365 | MMSL |
| 003612 | NDDF |
| 003613 | NDDF |
| 108578004 | SNOMEDCT_US |
| 386874003 | SNOMEDCT_US |
| 386875002 | SNOMEDCT_US |
| C0072858 | UMLSCUI |
| CHEMBL1733 | ChEMBL_ID |
| 82768-85-2 | SECONDARY_CAS_RN |
| 107994 | PUBCHEM_CID |
| 6352 | IUPHAR_LIGAND_ID |
| 6356 | INN_ID |
| C054501 | MESH_SUPPLEMENTAL_RECORD_UI |
| 34SSX5LDE5 | UNII |
| CHEBI:140296 | CHEBI |
| 34SSX5LDE5 | INXIGHT DRUGS |
| RJ84Y44811 | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-393 | TABLET | 5 mg | ORAL | ANDA | 24 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-394 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-267 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-268 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-269 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-270 | TABLET | 40 mg | ORAL | ANDA | 22 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-374 | TABLET | 10 mg | ORAL | ANDA | 23 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-375 | TABLET | 20 mg | ORAL | ANDA | 23 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 31722-376 | TABLET | 20 mg | ORAL | ANDA | 23 sections |
| Quinapril HCL and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43386-710 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
| Quinapril HCL and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43386-711 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
| Quinapril HCL and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 43386-712 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
| QUINAPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43547-410 | TABLET | 5 mg | ORAL | ANDA | 13 sections |
| QUINAPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43547-411 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
| QUINAPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43547-412 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
| QUINAPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43547-413 | TABLET | 40 mg | ORAL | ANDA | 13 sections |
| Quinapril | Human Prescription Drug Label | 1 | 50090-2116 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 20 sections |
| Quinapril | Human Prescription Drug Label | 1 | 50090-2117 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 20 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4649 | TABLET | 40 mg | ORAL | ANDA | 13 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51655-737 | TABLET | 40 mg | ORAL | ANDA | 12 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-1802 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 12 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-2847 | TABLET, FILM COATED | 20 nmol | ORAL | ANDA | 12 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5241 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 12 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5245 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 12 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5246 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 12 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5279 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 12 sections |
| Quinapril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5475 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 12 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-621 | TABLET | 5 mg | ORAL | ANDA | 19 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-622 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
| Quinapril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-623 | TABLET | 20 mg | ORAL | ANDA | 19 sections |