bisoprolol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 380 66722-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bisoprolol hemifumarate
  • bisoprolol
  • bisoprolol fumarate
A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
  • Molecular weight: 325.45
  • Formula: C18H31NO4
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -3.66
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 63 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.66 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 88 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK3,MAP2K6,MAPK7,NTRK2,PDK2,PDK4,PIM2,PRKDC,TEK,TGFBR1,ZAP70 27
kinase-selectivity-class CDK4 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
June 28, 2013 PMDA TOA EIYO LTD.
July 31, 1992 FDA TEVA WOMENS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2394.98 10.31 3348 211399 317039 90096661
Bradycardia 1690.49 10.31 1478 213269 82369 90331331
Drug interaction 1176.26 10.31 2241 212506 274212 90139488
Cardiac failure 1109.10 10.31 1332 213415 108164 90305536
Hyponatraemia 1026.65 10.31 1417 213330 132121 90281579
Hyperkalaemia 956.31 10.31 962 213785 64002 90349698
Atrial fibrillation 794.89 10.31 1257 213490 132354 90281346
Hypotension 752.23 10.31 2073 212674 323324 90090376
Glossodynia 663.74 10.31 22 214725 321757 90091943
Pemphigus 661.58 10.31 26 214721 326838 90086862
Systemic lupus erythematosus 621.18 10.31 67 214680 361829 90051871
Hand deformity 619.38 10.31 18 214729 296344 90117356
Lactic acidosis 579.20 10.31 655 214092 49808 90363892
Anaemia 569.78 10.31 1984 212763 350818 90062882
Syncope 545.32 10.31 1061 213686 131602 90282098
Drug ineffective 524.51 10.31 1619 213128 1382679 89031021
Melaena 489.47 10.31 503 214244 34294 90379406
Swelling 475.57 10.31 199 214548 418859 89994841
Helicobacter infection 469.48 10.31 15 214732 226835 90186865
Arthropathy 445.29 10.31 156 214591 366086 90047614
Infusion related reaction 440.10 10.31 219 214528 416561 89997139
Duodenal ulcer perforation 433.17 10.31 22 214725 221266 90192434
Synovitis 424.62 10.31 127 214620 329625 90084075
International normalised ratio increased 424.59 10.31 542 214205 46774 90366926
Folliculitis 407.47 10.31 18 214729 204335 90209365
Maternal exposure during pregnancy 403.61 10.31 174 214573 359889 90053811
Muscle injury 396.39 10.31 4 214743 176650 90237050
Pain 389.33 10.31 1147 213600 995194 89418506
Joint swelling 384.13 10.31 376 214371 502924 89910776
Rhabdomyolysis 383.09 10.31 537 214210 50719 90362981
Fall 373.65 10.31 2179 212568 479631 89934069
Renal impairment 373.54 10.31 793 213954 104628 90309072
Irritable bowel syndrome 372.63 10.31 32 214715 207416 90206284
Abdominal discomfort 368.42 10.31 353 214394 476975 89936725
Wound 368.30 10.31 129 214618 302851 90110849
Treatment failure 358.28 10.31 136 214611 303792 90109908
Therapeutic product effect decreased 349.92 10.31 111 214636 277460 90136240
Psoriatic arthropathy 349.64 10.31 60 214687 228275 90185425
Ischaemic stroke 342.14 10.31 337 214410 21829 90391871
Hypokalaemia 336.24 10.31 869 213878 130247 90283453
Discomfort 327.96 10.31 120 214627 274215 90139485
Fibromyalgia 327.51 10.31 49 214698 206220 90207480
Sinus bradycardia 325.57 10.31 291 214456 16661 90397039
General physical health deterioration 323.29 10.31 1678 213069 353437 90060263
Haematoma 321.86 10.31 429 214318 38619 90375081
Sinusitis 320.92 10.31 209 214538 342879 90070821
Alopecia 312.83 10.31 430 214317 494641 89919059
Cerebral haemorrhage 304.28 10.31 392 214355 34130 90379570
Hypoglycaemia 302.00 10.31 571 214176 69277 90344423
Arrhythmia 296.45 10.31 430 214317 41902 90371798
Drug hypersensitivity 294.56 10.31 401 214346 463208 89950492
Renal failure 289.50 10.31 822 213925 130185 90283515
Product prescribing error 289.04 10.31 357 214390 29788 90383912
Pericarditis 287.91 10.31 140 214607 270011 90143689
Injury 282.77 10.31 61 214686 197288 90216412
Atrioventricular block 281.88 10.31 204 214543 8611 90405089
Sopor 274.43 10.31 315 214432 24329 90389371
Hypertensive crisis 273.77 10.31 270 214477 17514 90396186
Atrioventricular block complete 273.32 10.31 209 214538 9602 90404098
Drug intolerance 272.54 10.31 399 214348 447192 89966508
Dehydration 272.32 10.31 1045 213702 193402 90220298
Electrocardiogram QT prolonged 271.74 10.31 558 214189 71898 90341802
Impaired healing 265.77 10.31 111 214636 234088 90179612
Joint range of motion decreased 263.76 10.31 14 214733 135629 90278071
Exposure during pregnancy 262.60 10.31 118 214629 238292 90175408
Contraindicated product administered 257.16 10.31 228 214519 319911 90093789
Rheumatoid factor positive 252.22 10.31 50 214697 171600 90242100
Cardiogenic shock 247.95 10.31 298 214449 24170 90389530
Swollen joint count increased 247.24 10.31 3 214744 111203 90302497
Stomatitis 243.94 10.31 177 214570 274521 90139179
Ill-defined disorder 243.74 10.31 68 214679 184823 90228877
Subarachnoid haemorrhage 243.09 10.31 254 214493 17650 90396050
Bursitis 242.82 10.31 18 214729 131636 90282064
Hypersensitivity 242.51 10.31 442 214305 454235 89959465
Type 2 diabetes mellitus 241.00 10.31 90 214657 203154 90210546
Product dose omission issue 238.78 10.31 204 214543 291483 90122217
Blister 236.10 10.31 157 214590 254841 90158859
Angina pectoris 234.74 10.31 370 214377 38790 90374910
Hypomagnesaemia 234.05 10.31 351 214396 35237 90378463
Blood cholesterol increased 233.74 10.31 100 214647 207912 90205788
Systemic infection 231.11 10.31 143 214604 4632 90409068
Rash 229.41 10.31 1039 213708 795061 89618639
Mitral valve incompetence 229.35 10.31 275 214472 22249 90391451
Cardiac failure chronic 228.39 10.31 151 214596 5495 90408205
Product use issue 226.39 10.31 269 214478 329650 90084050
Completed suicide 222.25 10.31 38 214709 145020 90268680
Nasopharyngitis 222.23 10.31 390 214357 406714 90006986
C-reactive protein abnormal 217.35 10.31 24 214723 127405 90286295
Lip dry 215.00 10.31 5 214742 100950 90312750
Gastrointestinal haemorrhage 213.87 10.31 581 214166 89667 90324033
Hepatic enzyme increased 213.26 10.31 328 214419 360408 90053292
International normalised ratio fluctuation 200.74 10.31 112 214635 2981 90410719
Palpitations 197.26 10.31 742 214005 135986 90277714
Haematemesis 197.10 10.31 315 214432 33411 90380289
Shock haemorrhagic 196.13 10.31 190 214557 12055 90401645
Circulatory collapse 195.16 10.31 267 214480 24637 90389063
Left ventricular dysfunction 193.62 10.31 205 214542 14464 90399236
Presyncope 192.69 10.31 302 214445 31503 90382197
Dyspnoea 188.58 10.31 3030 211717 877925 89535775
Anuria 184.88 10.31 201 214546 14617 90399083
Orthostatic hypotension 184.57 10.31 345 214402 41482 90372218
Off label use 183.33 10.31 1701 213046 1100551 89313149
Hemiplegia 182.36 10.31 208 214539 15952 90397748
Bradyarrhythmia 178.76 10.31 96 214651 2365 90411335
Upper gastrointestinal haemorrhage 176.53 10.31 244 214503 22732 90390968
Grip strength decreased 175.54 10.31 11 214736 92565 90321135
Weight increased 172.90 10.31 467 214280 417460 89996240
Night sweats 172.24 10.31 46 214701 128720 90284980
Hemiparesis 172.14 10.31 287 214460 31532 90382168
Sleep disorder 171.36 10.31 131 214616 197899 90215801
Infection 170.68 10.31 378 214369 361716 90051984
Hypoaesthesia 170.49 10.31 302 214445 313908 90099792
Gait inability 166.76 10.31 69 214678 146387 90267313
Road traffic accident 165.29 10.31 28 214719 107598 90306102
Asthma 164.40 10.31 199 214548 241961 90171739
Tachyarrhythmia 163.55 10.31 121 214626 5285 90408415
Arthralgia 161.61 10.31 1131 213616 777391 89636309
Rheumatoid arthritis 160.11 10.31 392 214355 362222 90051478
Cholestasis 159.66 10.31 299 214448 36000 90377700
Mobility decreased 157.89 10.31 218 214529 250516 90163184
Urticaria 157.84 10.31 314 214433 312420 90101280
Vertigo 156.04 10.31 440 214307 69371 90344329
Cerebral infarction 154.85 10.31 248 214499 26348 90387352
Atrial tachycardia 154.67 10.31 122 214625 5868 90407832
Subdural haematoma 154.55 10.31 194 214553 16451 90397249
Lower limb fracture 152.90 10.31 13 214734 85000 90328700
Lower respiratory tract infection 151.83 10.31 224 214523 250435 90163265
Ejection fraction decreased 151.76 10.31 244 214503 26009 90387691
Injection site pain 148.88 10.31 116 214631 173583 90240117
Peripheral venous disease 145.16 10.31 15 214732 83906 90329794
Acute myocardial infarction 144.34 10.31 280 214467 34610 90379090
Musculoskeletal stiffness 142.64 10.31 306 214441 296226 90117474
Cardiospasm 139.00 10.31 92 214655 3354 90410346
Bloody discharge 136.21 10.31 78 214669 2185 90411515
Metabolic acidosis 135.45 10.31 362 214385 55314 90358386
Ventricular tachycardia 135.18 10.31 224 214523 24484 90389216
Palmoplantar keratoderma 135.13 10.31 91 214656 3416 90410284
Osteoarthritis 134.79 10.31 159 214588 195571 90218129
Haematochezia 132.94 10.31 420 214327 70493 90343207
Autoimmune disorder 132.02 10.31 14 214733 76730 90336970
Pruritus genital 131.16 10.31 99 214648 4459 90409241
Hip arthroplasty 130.84 10.31 14 214733 76194 90337506
Live birth 129.71 10.31 17 214730 79090 90334610
Electrolyte imbalance 128.21 10.31 214 214533 23531 90390169
Cerebrovascular accident 127.19 10.31 605 214142 122928 90290772
Torsade de pointes 126.93 10.31 168 214579 15014 90398686
Eosinophilia 125.45 10.31 235 214512 28298 90385402
Acute coronary syndrome 125.10 10.31 141 214606 10672 90403028
Knee arthroplasty 124.76 10.31 23 214724 83159 90330541
Injection site erythema 124.71 10.31 39 214708 98463 90315237
Sciatica 123.34 10.31 43 214704 101339 90312361
Product monitoring error 122.63 10.31 95 214652 4449 90409251
Liver injury 122.40 10.31 134 214613 170433 90243267
Hallucination 122.13 10.31 389 214358 65570 90348130
Carotid artery thrombosis 121.66 10.31 128 214619 8964 90404736
Upper respiratory tract infection 121.42 10.31 77 214670 128241 90285459
Wound infection 121.32 10.31 50 214697 106352 90307348
Carotid artery occlusion 120.05 10.31 108 214639 6234 90407466
Labelled drug-drug interaction medication error 119.82 10.31 160 214587 14422 90399278
Aphasia 119.30 10.31 293 214454 42519 90371181
Wheezing 118.41 10.31 241 214506 237839 90175861
Blood pressure increased 116.13 10.31 833 213914 196384 90217316
Skin haemorrhage 115.85 10.31 193 214554 21187 90392513
Neurologic neglect syndrome 115.63 10.31 123 214624 8724 90404976
Injection site reaction 115.61 10.31 37 214710 92043 90321657
Atrial flutter 115.56 10.31 135 214612 10623 90403077
Sleep terror 115.44 10.31 91 214656 4373 90409327
Tachycardia 115.26 10.31 703 214044 156970 90256730
Hypercholesterolaemia 114.09 10.31 48 214699 100844 90312856
Pregnancy 112.93 10.31 9 214738 62038 90351662
Product quality issue 112.59 10.31 25 214722 79300 90334400
Myocardial infarction 112.01 10.31 523 214224 105449 90308251
Depression 111.78 10.31 353 214394 300248 90113452
Hallucination, visual 111.41 10.31 198 214549 22894 90390806
Hypocalcaemia 109.73 10.31 282 214465 42086 90371614
Bone erosion 107.88 10.31 4 214743 53017 90360683
Contusion 107.37 10.31 276 214471 250940 90162760
Blepharospasm 106.90 10.31 6 214741 55439 90358261
Asthenia 106.06 10.31 1815 212932 531936 89881764
Confusional state 105.83 10.31 1388 213359 384817 90028883
Oedema peripheral 105.41 10.31 1003 213744 256912 90156788
Adjustment disorder 105.24 10.31 122 214625 9520 90404180
Epistaxis 105.02 10.31 440 214307 84685 90329015
Cardioactive drug level increased 104.36 10.31 67 214680 2317 90411383
Obesity 103.04 10.31 61 214686 105446 90308254
Glomerular filtration rate decreased 102.87 10.31 161 214586 16771 90396929
Immunisation 101.37 10.31 64 214683 2149 90411551
Adverse event 101.13 10.31 78 214669 117340 90296360
Blood creatinine increased 101.08 10.31 492 214255 100894 90312806
Jaundice 100.84 10.31 232 214515 32285 90381415
Arterial occlusive disease 99.88 10.31 135 214612 12311 90401389
Therapy non-responder 98.51 10.31 107 214640 136597 90277103
Personality disorder 98.38 10.31 134 214613 12310 90401390
Product use in unapproved indication 98.18 10.31 436 214311 335800 90077900
Migraine 97.86 10.31 189 214558 190203 90223497
Dyspnoea exertional 97.39 10.31 384 214363 71904 90341796
Dysarthria 96.95 10.31 317 214430 54165 90359535
Hepatocellular injury 96.94 10.31 213 214534 28745 90384955
Exostosis 95.89 10.31 8 214739 53126 90360574
Vital capacity decreased 94.50 10.31 57 214690 1762 90411938
Loss of consciousness 94.23 10.31 612 214135 139626 90274074
X-ray abnormal 93.92 10.31 3 214744 45421 90368279
Lip swelling 93.87 10.31 251 214496 38359 90375341
Pancytopenia 92.86 10.31 544 214203 119719 90293981
Sinus node dysfunction 92.41 10.31 87 214660 5325 90408375
Polyneuropathy 92.23 10.31 165 214582 19176 90394524
Tinnitus 91.78 10.31 267 214480 42835 90370865
Urinary retention 91.39 10.31 245 214502 37499 90376201
Motor dysfunction 90.36 10.31 163 214584 19067 90394633
Ear infection 89.45 10.31 27 214720 69748 90343952
Adverse drug reaction 89.00 10.31 87 214660 116614 90297086
Sleep disorder due to a general medical condition 88.92 10.31 4 214743 44734 90368966
Laryngitis 87.96 10.31 9 214738 50744 90362956
Cardiac failure acute 87.64 10.31 124 214623 11805 90401895
Lyme disease 87.50 10.31 76 214671 4186 90409514
Haematuria 86.84 10.31 229 214518 34708 90378992
Gamma-glutamyltransferase increased 86.56 10.31 241 214506 37711 90375989
Rectal haemorrhage 86.43 10.31 407 214340 82337 90331363
Tension headache 85.31 10.31 97 214650 7412 90406288
Joint stiffness 85.27 10.31 39 214708 78003 90335697
Reversible airways obstruction 85.01 10.31 55 214692 1928 90411772
Erysipelas 84.83 10.31 106 214641 8946 90404754
Blood pressure decreased 84.62 10.31 377 214370 74518 90339182
Agranulocytosis 84.54 10.31 227 214520 34775 90378925
Prescribed overdose 83.88 10.31 65 214682 97560 90316140
Gastrointestinal disorder 83.55 10.31 319 214428 256368 90157332
Peripheral swelling 82.61 10.31 606 214141 412500 90001200
Sensory loss 82.13 10.31 151 214596 17924 90395776
Vasculitis 81.80 10.31 172 214575 22521 90391179
Disorientation 81.50 10.31 260 214487 43854 90369846
Back injury 81.49 10.31 8 214739 46614 90367086
Transient ischaemic attack 81.17 10.31 256 214491 42920 90370780
Lupus vulgaris 80.72 10.31 7 214740 45052 90368648
Injection site pruritus 80.48 10.31 15 214732 53819 90359881
Anosmia 79.30 10.31 107 214640 9741 90403959
Pleural effusion 79.10 10.31 495 214252 111496 90302204
Dizziness 78.76 10.31 1889 212858 587395 89826305
Microcytic anaemia 78.22 10.31 68 214679 3750 90409950
Hospitalisation 77.98 10.31 114 214633 127986 90285714
Haemarthrosis 77.55 10.31 69 214678 3925 90409775
Wrong patient received product 77.51 10.31 65 214682 3412 90410288
Gastrooesophageal reflux disease 77.17 10.31 175 214572 166162 90247538
Pallor 76.98 10.31 216 214531 33949 90379751
Inappropriate antidiuretic hormone secretion 76.40 10.31 153 214594 19352 90394348
Ventricular fibrillation 76.39 10.31 127 214620 13917 90399783
Sputum culture positive 76.30 10.31 54 214693 2199 90411501
Gangrene 76.24 10.31 121 214626 12755 90400945
Hypothermia 75.72 10.31 134 214613 15441 90398259
Onychomadesis 75.13 10.31 10 214737 45988 90367712
Lichen planopilaris 74.62 10.31 25 214722 175 90413525
Coeliac disease 74.56 10.31 9 214738 44601 90369099
Memory impairment 74.43 10.31 230 214517 197014 90216686
Disability 73.90 10.31 6 214741 40739 90372961
Inflammation 73.40 10.31 200 214547 178392 90235308
Thrombocytopenia 72.89 10.31 786 213961 207939 90205761
Hypovolaemic shock 72.85 10.31 87 214660 7007 90406693
Interstitial lung disease 72.75 10.31 366 214381 76039 90337661
Blood creatine phosphokinase increased 72.67 10.31 211 214536 33812 90379888
Altered state of consciousness 71.68 10.31 200 214547 31332 90382368
Fatigue 71.22 10.31 2138 212609 1151885 89261815
Hyponatraemic syndrome 70.42 10.31 32 214715 542 90413158
Death 70.21 10.31 717 214030 455834 89957866
Cerebral ischaemia 68.61 10.31 85 214662 7111 90406589
Nail disorder 68.56 10.31 27 214720 59040 90354660
Electrocardiogram abnormal 68.31 10.31 102 214645 10196 90403504
Lupus-like syndrome 68.11 10.31 16 214731 48830 90364870
Haemorrhage intracranial 68.05 10.31 126 214621 15036 90398664
Vasoplegia syndrome 67.73 10.31 55 214692 2759 90410941
Malignant mediastinal neoplasm 67.72 10.31 42 214705 1366 90412334
N-terminal prohormone brain natriuretic peptide increased 67.33 10.31 56 214691 2906 90410794
Insomnia 67.20 10.31 488 214259 332986 90080714
Onychomycosis 66.43 10.31 6 214741 37370 90376330
Pain in extremity 66.24 10.31 715 214032 449814 89963886
Coma scale abnormal 66.17 10.31 74 214673 5552 90408148
Faecaloma 65.90 10.31 101 214646 10330 90403370
Congestive cardiomyopathy 65.56 10.31 84 214663 7270 90406430
Tricuspid valve incompetence 65.24 10.31 131 214616 16600 90397100
Multiple organ dysfunction syndrome 64.81 10.31 327 214420 68009 90345691
Headache 63.35 10.31 1559 213188 861187 89552513
Affect lability 62.90 10.31 135 214612 17928 90395772
Femoral hernia incarcerated 62.62 10.31 41 214706 1467 90412233
Cardiovascular disorder 61.66 10.31 113 214634 13379 90400321
Myelosuppression 61.38 10.31 25 214722 53566 90360134
Therapy interrupted 61.38 10.31 21 214726 50087 90363613
Toxic epidermal necrolysis 61.26 10.31 193 214554 32335 90381365
Angioedema 61.22 10.31 310 214437 64566 90349134
Embolic stroke 61.14 10.31 61 214686 4011 90409689
Dry mouth 61.01 10.31 227 214520 183832 90229868
Bundle branch block left 60.96 10.31 84 214663 7801 90405899
Transaminases increased 60.51 10.31 210 214537 36982 90376718
Coordination abnormal 60.39 10.31 147 214600 21209 90392491
No adverse event 60.02 10.31 44 214703 67938 90345762
Musculoskeletal pain 59.54 10.31 207 214540 171044 90242656
Pemphigoid 59.30 10.31 89 214658 8937 90404763
Haemorrhagic stroke 59.17 10.31 75 214672 6421 90407279
Aortic valve stenosis 59.07 10.31 61 214686 4179 90409521
Myopathy 59.00 10.31 111 214636 13407 90400293
Polyuria 58.96 10.31 94 214653 9946 90403754
Tachypnoea 58.48 10.31 145 214602 21164 90392536
Hyperthyroidism 58.28 10.31 132 214615 18178 90395522
Intentional product use issue 58.11 10.31 290 214457 216602 90197098
Chronic kidney disease 57.71 10.31 254 214493 49937 90363763
Foot deformity 57.52 10.31 35 214712 59616 90354084
Walking aid user 57.32 10.31 8 214739 35498 90378202
Disease progression 56.71 10.31 186 214561 156429 90257271
Diplopia 56.51 10.31 173 214574 28541 90385159
Injection site swelling 56.47 10.31 36 214711 59803 90353897
Vomiting 56.40 10.31 2343 212404 785950 89627750
Illness 55.96 10.31 67 214680 81902 90331798
Paresis 54.92 10.31 48 214699 2666 90411034
Renin increased 54.65 10.31 20 214727 187 90413513
Prerenal failure 54.44 10.31 43 214704 2072 90411628
Neck pain 54.40 10.31 118 214629 113845 90299855
Dermatitis bullous 54.39 10.31 92 214655 10224 90403476
Potentiating drug interaction 54.17 10.31 67 214680 5595 90408105
Lymphatic fistula 54.12 10.31 37 214710 1424 90412276
Finger deformity 54.09 10.31 7 214740 32890 90380810
Bronchial secretion retention 54.00 10.31 54 214693 3561 90410139
Iron deficiency anaemia 53.70 10.31 150 214597 23512 90390188
Aortic arteriosclerosis 53.70 10.31 78 214669 7606 90406094
Unevaluable event 53.14 10.31 32 214715 54816 90358884
Abortion spontaneous 53.13 10.31 31 214716 54025 90359675
Pancreatic steatosis 52.50 10.31 38 214709 1604 90412096
BRASH syndrome 52.27 10.31 40 214707 1839 90411861
Atrial thrombosis 52.18 10.31 43 214704 2202 90411498
Heart rate decreased 52.13 10.31 258 214489 53247 90360453
Blood pressure systolic decreased 52.00 10.31 85 214662 9185 90404515
Arterial haemorrhage 51.82 10.31 45 214702 2478 90411222
Petechiae 51.80 10.31 115 214632 15626 90398074
Acute cutaneous lupus erythematosus 51.75 10.31 22 214725 315 90413385
Shock 51.69 10.31 168 214579 28610 90385090
Toxic skin eruption 51.64 10.31 115 214632 15659 90398041
Immunodeficiency 51.45 10.31 19 214728 43215 90370485
Bradyphrenia 51.36 10.31 76 214671 7536 90406164
Mental status changes 50.91 10.31 21 214726 44658 90369042
Disturbance in attention 50.86 10.31 234 214513 46875 90366825
Lupus vasculitis 50.66 10.31 26 214721 582 90413118
Atrioventricular block first degree 50.41 10.31 80 214667 8431 90405269
Paraesthesia 50.08 10.31 367 214380 249959 90163741
Injection site bruising 50.00 10.31 31 214716 52276 90361424
Coronary artery stenosis 49.88 10.31 62 214685 5204 90408496
Oliguria 49.84 10.31 90 214657 10534 90403166
Urine output decreased 49.53 10.31 99 214648 12504 90401196
Respiratory tract congestion 49.22 10.31 160 214587 27250 90386450
Faeces discoloured 49.22 10.31 136 214611 21184 90392516
Restlessness 49.12 10.31 191 214556 35529 90378171
Orthopnoea 48.67 10.31 70 214677 6765 90406935
Foetal growth restriction 48.59 10.31 83 214664 9297 90404403
Left ventricular failure 48.27 10.31 69 214678 6631 90407069
Retroperitoneal haematoma 47.91 10.31 49 214698 3319 90410381
Stress cardiomyopathy 47.87 10.31 101 214646 13254 90400446
Facial pain 47.61 10.31 100 214647 13082 90400618
Sinus congestion 47.38 10.31 158 214589 27266 90386434
Iron deficiency 47.12 10.31 83 214664 9529 90404171
Pancreatitis acute 46.86 10.31 175 214572 31940 90381760
Neuropathy peripheral 46.65 10.31 167 214580 136803 90276897
Ear pain 46.37 10.31 41 214706 57661 90356039
Blindness 45.84 10.31 153 214594 26415 90387285
Subcutaneous haematoma 45.73 10.31 37 214710 1846 90411854
Wound infection pseudomonas 45.47 10.31 38 214709 1985 90411715
Injection site rash 45.44 10.31 3 214744 24170 90389530
Coma 45.17 10.31 311 214436 72321 90341379
Drug reaction with eosinophilia and systemic symptoms 45.14 10.31 211 214536 42547 90371153
Diverticulum intestinal 44.89 10.31 79 214668 9063 90404637
Cerebral haematoma 44.70 10.31 53 214694 4236 90409464
Hepatitis acute 44.57 10.31 87 214660 10800 90402900
Osteoporosis 44.40 10.31 102 214645 96429 90317271
Haematoma muscle 44.19 10.31 36 214711 1814 90411886
Pulmonary oedema 43.57 10.31 274 214473 61806 90351894
Bundle branch block right 43.53 10.31 59 214688 5394 90408306
Spontaneous haemorrhage 43.41 10.31 25 214722 708 90412992
Abnormal loss of weight 43.01 10.31 66 214681 6757 90406943
Full blood count decreased 42.85 10.31 9 214738 29680 90384020
Abdominal wall haematoma 42.74 10.31 46 214701 3306 90410394
Lung disorder 42.70 10.31 196 214551 149687 90264013
Rash maculo-papular 42.48 10.31 201 214546 40732 90372968
Ketoacidosis 42.35 10.31 59 214688 5536 90408164
Taste disorder 42.33 10.31 50 214697 61496 90352204
Acute pulmonary oedema 42.23 10.31 79 214668 9501 90404199
Femoral neck fracture 42.17 10.31 82 214665 10151 90403549
Ventricular extrasystoles 41.59 10.31 95 214652 13155 90400545
Blood loss anaemia 41.47 10.31 81 214666 10059 90403641
Lower gastrointestinal haemorrhage 41.30 10.31 75 214672 8817 90404883
Sneezing 41.30 10.31 160 214587 29709 90383991
Product administration error 41.09 10.31 147 214600 26276 90387424
Eye pruritus 40.55 10.31 156 214591 28871 90384829
Food allergy 40.53 10.31 6 214741 25472 90388228
Hyperglycaemia 40.26 10.31 232 214515 50738 90362962
Muscle spasms 40.15 10.31 392 214355 251491 90162209
Eating disorder 40.15 10.31 152 214595 27921 90385779
Therapy cessation 39.99 10.31 18 214729 36343 90377357
Face oedema 39.98 10.31 134 214613 23184 90390516
Ventricular arrhythmia 39.54 10.31 50 214697 4271 90409429
Adverse reaction 38.99 10.31 11 214736 29701 90383999
Leukopenia 38.80 10.31 387 214360 100323 90313377
Therapeutic drug monitoring analysis not performed 38.54 10.31 29 214718 1300 90412400
Lethargy 38.46 10.31 269 214478 62870 90350830
Therapeutic product effect incomplete 38.42 10.31 285 214462 193611 90220089
Incorrect route of product administration 38.29 10.31 38 214709 50588 90363112
Hepatitis cholestatic 38.24 10.31 71 214676 8490 90405210
Orthostatic intolerance 38.06 10.31 29 214718 1325 90412375
Eosinophil count increased 38.01 10.31 91 214656 12990 90400710
Drug ineffective for unapproved indication 37.97 10.31 62 214685 66582 90347118
Cardiac arrest 37.93 10.31 398 214349 104537 90309163
Alanine aminotransferase increased 37.80 10.31 438 214309 117900 90295800
Sinus arrest 37.60 10.31 35 214712 2111 90411589
Pain of skin 37.53 10.31 103 214644 15979 90397721
Optic ischaemic neuropathy 37.51 10.31 32 214715 1720 90411980
Pulmonary fibrosis 37.32 10.31 130 214617 107373 90306327
Sight disability 37.25 10.31 14 214733 142 90413558
Vitamin B12 decreased 37.25 10.31 54 214693 5256 90408444
Blood immunoglobulin E increased 37.04 10.31 49 214698 4376 90409324
Drug monitoring procedure not performed 36.65 10.31 23 214724 764 90412936
Acidosis 36.37 10.31 88 214659 12648 90401052
Hypersensitivity vasculitis 36.28 10.31 47 214700 4112 90409588
Cardiac tamponade 36.24 10.31 55 214692 5577 90408123
Drug level increased 36.20 10.31 146 214601 27616 90386084
Gravitational oedema 36.04 10.31 27 214720 1202 90412498
Tachycardia paroxysmal 35.93 10.31 17 214730 317 90413383
Pulmonary embolism 35.66 10.31 470 214277 130350 90283350
N-terminal prohormone brain natriuretic peptide abnormal 35.46 10.31 11 214736 58 90413642
Somnolence 35.43 10.31 694 214053 208390 90205310
Intestinal haemorrhage 35.32 10.31 48 214699 4399 90409301
Head injury 35.22 10.31 157 214590 31031 90382669
Colitis erosive 35.15 10.31 15 214732 217 90413483
Medication error 34.92 10.31 330 214417 84322 90329378
White blood cell count decreased 34.37 10.31 243 214504 166866 90246834
Macular degeneration 34.27 10.31 24 214723 37946 90375754
Psychomotor retardation 34.03 10.31 49 214698 4740 90408960
Basilar artery occlusion 33.88 10.31 14 214733 186 90413514
Conjoined twins 33.87 10.31 19 214728 511 90413189
Seroma 33.87 10.31 39 214708 3021 90410679
Muscle twitching 33.75 10.31 130 214617 24072 90389628
Vascular purpura 33.69 10.31 30 214717 1708 90411992
Tubulointerstitial nephritis 33.62 10.31 134 214613 25209 90388491
Oedema 33.50 10.31 308 214439 199987 90213713
Epileptic encephalopathy 33.47 10.31 17 214730 372 90413328
Multiple sclerosis relapse 33.36 10.31 45 214702 52260 90361440
Gastric ulcer 33.16 10.31 141 214606 27307 90386393
Anaemia macrocytic 32.81 10.31 47 214700 4525 90409175
Chronic sinusitis 32.78 10.31 8 214739 23794 90389906
Hemianopia 32.77 10.31 32 214715 2050 90411650
Myocardial ischaemia 32.76 10.31 89 214658 13725 90399975
Thalamus haemorrhage 32.56 10.31 21 214726 732 90412968
Dyspnoea at rest 32.56 10.31 48 214699 4743 90408957
Dysphagia 32.55 10.31 408 214339 111870 90301830
Malaise 32.41 10.31 1698 213049 584288 89829412
Liver function test abnormal 32.38 10.31 219 214528 50626 90363074
Seronegative arthritis 32.21 10.31 3 214744 18231 90395469
Sinus disorder 32.07 10.31 164 214583 34283 90379417
Urosepsis 32.07 10.31 117 214630 21115 90392585
Fracture 31.96 10.31 120 214627 21956 90391744
Supraventricular extrasystoles 31.95 10.31 50 214697 5207 90408493
Peripheral ischaemia 31.83 10.31 52 214695 5615 90408085
Hypochloraemia 31.72 10.31 35 214712 2587 90411113
Accidental overdose 31.68 10.31 142 214605 28131 90385569
Bronchitis 31.64 10.31 222 214525 152705 90260995
Nocturia 31.61 10.31 73 214674 10182 90403518
Peripheral embolism 31.51 10.31 26 214721 1334 90412366
Liver disorder 31.41 10.31 164 214583 121105 90292595
Dermatitis exfoliative 31.37 10.31 51 214696 5485 90408215
Laboratory test abnormal 30.99 10.31 32 214715 41822 90371878
Sudden death 30.75 10.31 75 214672 10834 90402866
Amaurosis 30.70 10.31 21 214726 809 90412891
Diabetic metabolic decompensation 30.65 10.31 30 214717 1927 90411773
Frequent bowel movements 30.57 10.31 55 214692 56880 90356820
Cystitis 30.53 10.31 266 214481 66452 90347248
Intestinal transit time abnormal 30.35 10.31 10 214737 66 90413634
Normochromic normocytic anaemia 30.28 10.31 48 214699 5054 90408646
Hepatic cytolysis 30.06 10.31 149 214598 30767 90382933
Product dose omission in error 30.04 10.31 6 214741 20497 90393203
Overdose 30.01 10.31 533 214214 157176 90256524
Electrocardiogram ST segment elevation 29.88 10.31 42 214705 3974 90409726
Hepatic function abnormal 29.85 10.31 200 214547 46088 90367612
Hepatic cirrhosis 29.76 10.31 66 214681 63187 90350513
Vascular encephalopathy 29.71 10.31 20 214727 750 90412950
Erythrodermic psoriasis 29.58 10.31 23 214724 1083 90412617
Diverticulum intestinal haemorrhagic 29.48 10.31 28 214719 1733 90411967
Agitation 29.40 10.31 265 214482 66833 90346867
Sinoatrial block 29.30 10.31 22 214725 983 90412717
Injection site urticaria 29.21 10.31 4 214743 18007 90395693
Device issue 28.94 10.31 17 214730 29520 90384180
Congenital bladder anomaly 28.62 10.31 13 214734 220 90413480
Blood pressure systolic increased 28.48 10.31 236 214511 58109 90355591
Thermohypoaesthesia 28.39 10.31 11 214736 122 90413578
Duodenal ulcer 28.35 10.31 67 214680 9485 90404215
Urachal abnormality 28.20 10.31 13 214734 228 90413472
Waist circumference increased 28.01 10.31 21 214726 936 90412764
Extrasystoles 27.92 10.31 49 214698 5608 90408092
Eructation 27.72 10.31 72 214675 10810 90402890
Anal haemorrhage 27.65 10.31 32 214715 2492 90411208
Condition aggravated 27.65 10.31 1142 213605 594403 89819297
Gastroenteritis viral 27.64 10.31 19 214728 30336 90383364
Infective spondylitis 27.61 10.31 12 214735 182 90413518
Persistent cloaca 27.55 10.31 13 214734 241 90413459
Polycythaemia 27.54 10.31 23 214724 1200 90412500
Troponin T increased 27.54 10.31 26 214721 1597 90412103
Haemorrhagic diathesis 27.46 10.31 48 214699 5476 90408224
Acute generalised exanthematous pustulosis 27.37 10.31 83 214664 13620 90400080
Androgenetic alopecia 27.31 10.31 12 214735 187 90413513
Stress 27.21 10.31 100 214647 81295 90332405
Cholestatic liver injury 27.20 10.31 39 214708 3758 90409942
Device malfunction 27.10 10.31 8 214739 20969 90392731
Therapeutic response decreased 26.96 10.31 115 214632 89614 90324086
Dyspepsia 26.90 10.31 320 214427 197840 90215860
Peripheral arterial occlusive disease 26.77 10.31 43 214704 4578 90409122
Drug tolerance 26.76 10.31 5 214742 17911 90395789
Hyperuricaemia 26.67 10.31 53 214694 6666 90407034
Retroperitoneal fibrosis 26.62 10.31 14 214733 330 90413370
Liver function test increased 26.59 10.31 107 214640 84748 90328952
Colitis microscopic 26.57 10.31 72 214675 11087 90402613
Spontaneous haematoma 26.54 10.31 22 214725 1136 90412564
Infusion site pain 26.48 10.31 7 214740 19731 90393969
Sudden hearing loss 26.48 10.31 24 214723 1399 90412301
Rash scarlatiniform 26.48 10.31 12 214735 202 90413498
Neutropenia 26.40 10.31 709 214038 224195 90189505
Language disorder 26.37 10.31 32 214715 2620 90411080
Haemorrhagic transformation stroke 26.34 10.31 23 214724 1276 90412424
Cardiomyopathy 26.13 10.31 106 214641 20100 90393600
Skin necrosis 26.13 10.31 94 214653 16847 90396853
Hypereosinophilic syndrome 26.03 10.31 14 214733 346 90413354
Intestinal malrotation 25.85 10.31 15 214732 431 90413269
Rash papular 25.71 10.31 106 214641 20249 90393451
Accidental exposure to product 25.48 10.31 38 214709 42328 90371372
Long QT syndrome 25.38 10.31 39 214708 3998 90409702
Hepatic cyst 25.10 10.31 51 214696 6517 90407183
Tooth disorder 25.09 10.31 22 214725 31068 90382632
Emotional distress 24.98 10.31 30 214717 36632 90377068
Neuropathy, ataxia, retinitis pigmentosa syndrome 24.93 10.31 8 214739 48 90413652
Neonatal gastrointestinal disorder 24.90 10.31 9 214738 81 90413619
Ventricular hypokinesia 24.74 10.31 45 214702 5296 90408404
Female genital tract fistula 24.62 10.31 6 214741 17862 90395838
Fluid retention 24.61 10.31 116 214631 87975 90325725
Thiopurine methyltransferase decreased 24.59 10.31 13 214734 310 90413390
Bicytopenia 24.51 10.31 37 214710 3734 90409966
Serum procollagen type I N-terminal propeptide increased 24.33 10.31 7 214740 27 90413673
Hepatorenal failure 24.29 10.31 17 214730 680 90413020
Dilatation ventricular 24.17 10.31 29 214718 2347 90411353
Left atrial enlargement 24.16 10.31 17 214730 686 90413014
Eye irritation 24.02 10.31 27 214720 33951 90379749
Embolic cerebral infarction 23.99 10.31 16 214731 591 90413109
Supraventricular tachycardia 23.81 10.31 89 214658 16247 90397453
Brain stem haemorrhage 23.80 10.31 18 214729 813 90412887
Infective exacerbation of chronic obstructive airways disease 23.69 10.31 23 214724 1463 90412237
Hepatocellular carcinoma 23.66 10.31 29 214718 2399 90411301
Cognitive disorder 23.56 10.31 260 214487 69147 90344553
Retinal artery occlusion 23.56 10.31 28 214719 2243 90411457
Surgery 23.53 10.31 44 214703 44843 90368857
Inflammatory marker increased 23.51 10.31 61 214686 9153 90404547
Allergic sinusitis 23.50 10.31 27 214720 2086 90411614
Irritability 23.44 10.31 30 214717 35632 90378068
Breath sounds abnormal 23.42 10.31 85 214662 15301 90398399
Shock symptom 23.37 10.31 12 214735 269 90413431
Diabetes mellitus inadequate control 23.36 10.31 97 214650 18587 90395113
Metabolic alkalosis 23.32 10.31 35 214712 3514 90410186
Oral herpes 23.31 10.31 27 214720 33497 90380203
Nasal congestion 23.21 10.31 110 214637 83304 90330396
Basal cell carcinoma 23.20 10.31 147 214600 33242 90380458
Myalgia 23.17 10.31 561 214186 174564 90239136
Multimorbidity 23.17 10.31 16 214731 626 90413074
Sinus rhythm 23.13 10.31 22 214725 1364 90412336
Renal tubular disorder 23.06 10.31 33 214714 3174 90410526
Cough 23.03 10.31 1082 213665 367880 90045820
Weight fluctuation 22.96 10.31 9 214738 19740 90393960
Pneumonitis 22.82 10.31 181 214566 43989 90369711
Eczema 22.75 10.31 208 214539 52662 90361038
Sedation complication 22.75 10.31 6 214741 16938 90396762
Hyperhidrosis 22.60 10.31 451 214296 135854 90277846
Immobile 22.48 10.31 48 214699 6350 90407350
Aortic valve incompetence 22.48 10.31 49 214698 6575 90407125
Exercise tolerance decreased 22.45 10.31 53 214694 7498 90406202
Craniofacial fracture 22.36 10.31 14 214733 463 90413237
Nephrosclerosis 22.31 10.31 20 214727 1149 90412551
Brain natriuretic peptide increased 22.21 10.31 46 214701 5959 90407741
Aortic dissection 22.16 10.31 28 214719 2389 90411311
General symptom 22.11 10.31 4 214743 14664 90399036
Respiratory disorder 22.08 10.31 79 214668 64737 90348963
Hepatitis toxic 22.04 10.31 35 214712 3690 90410010
Respiratory acidosis 22.02 10.31 55 214692 8064 90405636
Wound dehiscence 22.00 10.31 45 214702 5777 90407923
Muscle haemorrhage 21.99 10.31 33 214714 3313 90410387
Periorbital haematoma 21.98 10.31 17 214730 794 90412906
Cerebral artery occlusion 21.97 10.31 19 214728 1040 90412660
Purpura 21.95 10.31 81 214666 14697 90399003
Wrong product administered 21.93 10.31 53 214694 7612 90406088
Sinobronchitis 21.90 10.31 16 214731 685 90413015
Catarrh 21.85 10.31 23 214724 1611 90412089
Hypoglycaemic coma 21.84 10.31 31 214716 2959 90410741
Bone density decreased 21.71 10.31 7 214740 17338 90396362
Ocular icterus 21.66 10.31 36 214711 3944 90409756
Deprescribing error 21.54 10.31 7 214740 44 90413656
Nodal rhythm 21.53 10.31 24 214723 1794 90411906
Gallbladder disorder 21.47 10.31 10 214737 19793 90393907
Skin dystrophy 21.40 10.31 7 214740 45 90413655
Eye disorder 21.36 10.31 20 214727 27370 90386330
Peripheral coldness 21.36 10.31 77 214670 13815 90399885
Muscular weakness 21.33 10.31 641 214106 206025 90207675
Small cell carcinoma 21.31 10.31 10 214737 183 90413517
Ileus paralytic 21.26 10.31 41 214706 5044 90408656
Hypertensive angiopathy 21.21 10.31 8 214739 82 90413618
Product blister packaging issue 21.15 10.31 12 214735 330 90413370
Septic shock 21.14 10.31 298 214449 83862 90329838
Flushing 21.09 10.31 123 214624 88368 90325332
Transcription medication error 21.05 10.31 11 214736 256 90413444
Pruritus 20.95 10.31 1059 213688 540466 89873234
Craniocerebral injury 20.93 10.31 32 214715 3266 90410434
Haemoglobin decreased 20.88 10.31 517 214230 161439 90252261
Intentional dose omission 20.85 10.31 8 214739 17775 90395925
Respiratory tract infection 20.84 10.31 223 214524 58855 90354845
Hypernatraemia 20.80 10.31 59 214688 9328 90404372
Myocarditis 20.78 10.31 76 214671 13730 90399970
Normal newborn 20.78 10.31 15 214732 23347 90390353
Basal ganglia haemorrhage 20.73 10.31 16 214731 745 90412955
Immune thrombocytopenia 20.60 10.31 74 214673 13252 90400448
Blood urea increased 20.57 10.31 133 214614 30280 90383420
Tuberculosis of central nervous system 20.46 10.31 12 214735 352 90413348
Cardiomegaly 20.42 10.31 94 214653 18831 90394869
Febrile bone marrow aplasia 20.42 10.31 60 214687 9678 90404022
Abdominal pain 20.31 10.31 1139 213608 394582 90019118
Subacute cutaneous lupus erythematosus 20.30 10.31 33 214714 3549 90410151
Nodule 20.22 10.31 20 214727 26666 90387034
Foetal death 20.20 10.31 12 214735 20711 90392989
Pericardial effusion 20.17 10.31 153 214594 36680 90377020
Peripartum cardiomyopathy 20.15 10.31 10 214737 208 90413492
Procollagen type I C-terminal propeptide increased 20.12 10.31 6 214741 27 90413673
Blood sodium decreased 20.08 10.31 123 214624 27490 90386210
Rash vesicular 20.02 10.31 9 214738 18188 90395512
Walking disability 19.92 10.31 21 214726 1474 90412226
Thirst 19.91 10.31 84 214663 16211 90397489
Ischaemic cerebral infarction 19.79 10.31 21 214726 1485 90412215
Acne 19.77 10.31 23 214724 28484 90385216
Bladder sphincter atony 19.72 10.31 10 214737 218 90413482
Blood uric acid increased 19.65 10.31 51 214696 7653 90406047
Coagulation time prolonged 19.49 10.31 22 214725 1668 90412032
Gastrointestinal sounds abnormal 19.45 10.31 37 214710 4506 90409194
Ventricular internal diameter abnormal 19.44 10.31 6 214741 31 90413669
Troponin I increased 19.42 10.31 27 214720 2528 90411172
Monoparesis 19.42 10.31 24 214723 2003 90411697
Chest injury 19.22 10.31 24 214723 2024 90411676
Body temperature decreased 19.19 10.31 109 214638 23707 90389993
Pulmonary hypertension 19.17 10.31 169 214578 42354 90371346
Coronary artery disease 19.17 10.31 141 214606 33482 90380218
Enanthema 19.09 10.31 13 214734 497 90413203
Cachexia 19.08 10.31 47 214700 6831 90406869
Haemothorax 19.06 10.31 26 214721 2392 90411308
Deformity 19.05 10.31 3 214744 12167 90401533
Procedural pain 19.04 10.31 31 214716 33329 90380371
Mixed liver injury 18.97 10.31 50 214697 7573 90406127
Foetal heart rate disorder 18.92 10.31 9 214738 170 90413530
Intestinal ischaemia 18.88 10.31 55 214692 8828 90404872
Fungal infection 18.88 10.31 46 214701 42615 90371085
Emotional disorder 18.87 10.31 6 214741 14991 90398709
Adrenal insufficiency 18.82 10.31 26 214721 29895 90383805
Haemorrhage 18.80 10.31 249 214498 69120 90344580
Mood swings 18.79 10.31 13 214734 20689 90393011
Aortic valve calcification 18.75 10.31 14 214733 620 90413080
Multiple sclerosis 18.74 10.31 23 214724 27817 90385883
Escherichia infection 18.69 10.31 81 214666 15814 90397886
Subileus 18.56 10.31 32 214715 3612 90410088
Neovascular age-related macular degeneration 18.54 10.31 12 214735 421 90413279
Skin exfoliation 18.50 10.31 244 214503 67669 90346031
Faeces pale 18.41 10.31 23 214724 1940 90411760
Cyanosis 18.37 10.31 93 214654 19362 90394338
Cardiovascular insufficiency 18.37 10.31 21 214726 1614 90412086
Urinary tract infection 18.37 10.31 893 213854 304739 90108961
Psychogenic visual disorder 18.34 10.31 5 214742 15 90413685
Urinary straining 18.29 10.31 6 214741 39 90413661
Peripheral artery haematoma 18.29 10.31 6 214741 39 90413661
Pleurothotonus 18.23 10.31 19 214728 1316 90412384
Cerebellar haemorrhage 18.18 10.31 21 214726 1632 90412068
Neonatal respiratory depression 18.14 10.31 9 214738 187 90413513
Retrograde amnesia 18.12 10.31 13 214734 541 90413159
Infusion site swelling 18.10 10.31 3 214744 11717 90401983
Erythema 18.07 10.31 689 214058 228557 90185143
Musculoskeletal discomfort 17.99 10.31 14 214733 20977 90392723
Dysaesthesia 17.98 10.31 39 214708 5216 90408484
Suicidal ideation 17.95 10.31 102 214645 73753 90339947
Complication associated with device 17.94 10.31 12 214735 19437 90394263
Trisomy 21 17.92 10.31 12 214735 446 90413254
Dyspnoea paroxysmal nocturnal 17.75 10.31 17 214730 1063 90412637
Administration site discomfort 17.74 10.31 8 214739 133 90413567
Product complaint 17.71 10.31 5 214742 13495 90400205
Mucosal dryness 17.71 10.31 29 214718 3138 90410562
Antipsychotic drug level above therapeutic 17.66 10.31 19 214728 1365 90412335
Oropharyngeal pain 17.61 10.31 181 214566 115006 90298694
Sudden cardiac death 17.59 10.31 24 214723 2208 90411492
Abdominal pain upper 17.59 10.31 628 214119 332046 90081654
Atrioventricular block second degree 17.53 10.31 35 214712 4417 90409283
Gonorrhoea 17.53 10.31 8 214739 137 90413563
Gastritis erosive 17.52 10.31 45 214702 6710 90406990
Peripheral sensory neuropathy 17.52 10.31 55 214692 9195 90404505
Ischaemic cardiomyopathy 17.50 10.31 26 214721 2587 90411113
Kussmaul respiration 17.50 10.31 10 214737 279 90413421
Weight decreased 17.49 10.31 729 214018 379181 90034519
Ulcer haemorrhage 17.45 10.31 22 214725 26299 90387401
Red cell distribution width abnormal 17.43 10.31 9 214738 204 90413496
Injection site haemorrhage 17.42 10.31 25 214722 28293 90385407
Cerebellar infarction 17.37 10.31 24 214723 2234 90411466
Subdural haemorrhage 17.35 10.31 30 214717 3393 90410307
Gastric pH increased 17.33 10.31 6 214741 47 90413653
Blood calcium decreased 17.27 10.31 28 214719 30154 90383546
Extensor plantar response 17.18 10.31 19 214728 1408 90412292
Disease recurrence 17.14 10.31 40 214707 37613 90376087
Maternal exposure before pregnancy 17.03 10.31 3 214744 11210 90402490
Angina unstable 16.92 10.31 46 214701 7097 90406603
Hyporesponsive to stimuli 16.88 10.31 20 214727 1597 90412103
Staphylococcal scalded skin syndrome 16.87 10.31 8 214739 150 90413550
Gingival bleeding 16.81 10.31 75 214672 14828 90398872
Full blood count abnormal 16.78 10.31 146 214601 36451 90377249
Sepsis 16.78 10.31 551 214196 179263 90234437
Pulmonary haematoma 16.77 10.31 8 214739 152 90413548
Brain stem infarction 16.77 10.31 15 214732 859 90412841
Prohormone brain natriuretic peptide increased 16.76 10.31 10 214737 303 90413397
Renal artery stenosis 16.54 10.31 23 214724 2154 90411546
Loss of personal independence in daily activities 16.52 10.31 225 214522 135880 90277820
Cardiac valve sclerosis 16.51 10.31 5 214742 24 90413676
Insurance issue 16.49 10.31 3 214744 10955 90402745
Intracardiac thrombus 16.45 10.31 24 214723 2350 90411350
Connective tissue inflammation 16.41 10.31 6 214741 56 90413644
Pustular psoriasis 16.39 10.31 12 214735 18544 90395156
Therapeutic response shortened 16.37 10.31 18 214729 22861 90390839
Polydipsia 16.34 10.31 33 214714 4198 90409502
Heart rate irregular 16.34 10.31 106 214641 24162 90389538
Anticoagulant-related nephropathy 16.34 10.31 5 214742 25 90413675
Anticoagulation drug level above therapeutic 16.33 10.31 22 214725 2000 90411700
Haemorrhagic infarction 16.32 10.31 10 214737 318 90413382
Tetany 16.30 10.31 25 214722 2559 90411141
Renal aplasia 16.28 10.31 11 214736 415 90413285
Cardiac dysfunction 16.28 10.31 30 214717 3567 90410133
Ecchymosis 16.22 10.31 65 214682 12258 90401442
Term birth 16.18 10.31 8 214739 165 90413535
Pharyngeal haemorrhage 16.17 10.31 13 214734 643 90413057
Therapy partial responder 16.15 10.31 17 214730 22026 90391674
Fear of eating 16.14 10.31 11 214736 421 90413279
Drug eruption 16.11 10.31 141 214606 35266 90378434
Clostridium difficile infection 16.10 10.31 39 214708 36206 90377494
Inappropriate schedule of product administration 16.07 10.31 254 214493 149679 90264021
Cannabinoid hyperemesis syndrome 16.04 10.31 6 214741 60 90413640
Platelet aggregation decreased 16.02 10.31 5 214742 27 90413673
Fear of falling 15.98 10.31 13 214734 654 90413046
Escherichia urinary tract infection 15.94 10.31 70 214677 13745 90399955
Osteonecrosis of jaw 15.90 10.31 152 214595 38951 90374749
Chest discomfort 15.89 10.31 435 214312 137930 90275770
Myoglobin blood increased 15.88 10.31 19 214728 1533 90412167
First trimester pregnancy 15.81 10.31 4 214743 8 90413692
Prurigo 15.77 10.31 15 214732 930 90412770
Dry eye 15.76 10.31 77 214670 57854 90355846
Hysterectomy 15.75 10.31 4 214743 11580 90402120
Obstructive pancreatitis 15.74 10.31 13 214734 668 90413032
Chills 15.73 10.31 219 214528 131762 90281938
Candida infection 15.64 10.31 36 214711 34021 90379679
Obstructive airways disorder 15.63 10.31 110 214637 25759 90387941
Psychomotor hyperactivity 15.61 10.31 66 214681 12747 90400953
Calcification metastatic 15.59 10.31 8 214739 179 90413521
Pustule 15.58 10.31 26 214721 2857 90410843
Respiratory arrest 15.47 10.31 35 214712 33276 90380424
Seasonal allergy 15.46 10.31 19 214728 22964 90390736
Orbital swelling 15.45 10.31 6 214741 67 90413633
Behaviour disorder 15.41 10.31 34 214713 4601 90409099
Lip oedema 15.39 10.31 34 214713 4605 90409095
Peripheral circulatory failure 15.38 10.31 19 214728 1585 90412115
General physical condition abnormal 15.33 10.31 36 214711 5075 90408625
Eye haematoma 15.33 10.31 7 214740 120 90413580
Nightmare 15.31 10.31 96 214651 21629 90392071
Bradypnoea 15.29 10.31 34 214713 4624 90409076
Psoriasis 15.27 10.31 252 214495 147502 90266198
Immunoglobulins increased 15.27 10.31 12 214735 574 90413126
Meningioma surgery 15.22 10.31 6 214741 70 90413630
Spinal ligament ossification 15.14 10.31 3 214744 0 90413700
Paranasal sinus haematoma 15.14 10.31 3 214744 0 90413700
Bifascicular block 15.12 10.31 7 214740 124 90413576
Anaemia megaloblastic 15.12 10.31 11 214736 468 90413232
Nodal arrhythmia 15.09 10.31 17 214730 1286 90412414
Traumatic haemorrhage 15.07 10.31 12 214735 585 90413115
Wrong patient 15.06 10.31 14 214733 843 90412857
Radiculopathy 15.05 10.31 13 214734 18492 90395208
Wrong strength 14.99 10.31 6 214741 73 90413627
Groin pain 14.95 10.31 63 214684 12150 90401550
Cerebral artery embolism 14.89 10.31 15 214732 998 90412702
Hepatitis 14.88 10.31 243 214504 70496 90343204
Tongue oedema 14.84 10.31 37 214710 5417 90408283
Hypokinesia 14.80 10.31 75 214672 15622 90398078
Myopathy toxic 14.78 10.31 12 214735 602 90413098
Blood aldosterone increased 14.75 10.31 8 214739 201 90413499
Phaeochromocytoma 14.72 10.31 12 214735 605 90413095
Cerebellar syndrome 14.72 10.31 30 214717 3842 90409858
Hypertrophic cardiomyopathy 14.68 10.31 22 214725 2206 90411494
Microencephaly 14.67 10.31 4 214743 12 90413688
Glomerular filtration rate abnormal 14.65 10.31 17 214730 1328 90412372
Rhinitis allergic 14.64 10.31 11 214736 16774 90396926
Musculoskeletal disorder 14.63 10.31 18 214729 21751 90391949
Nodular melanoma 14.57 10.31 6 214741 79 90413621
Coronavirus test positive 14.54 10.31 14 214733 881 90412819
Hepatic failure 14.50 10.31 151 214596 39577 90374123
Blood alkaline phosphatase increased 14.48 10.31 176 214571 47903 90365797
Anal polyp 14.43 10.31 6 214741 81 90413619
Osmotic demyelination syndrome 14.39 10.31 15 214732 1039 90412661
Eyelid retraction 14.37 10.31 6 214741 82 90413618
Cerebrovascular arteriovenous malformation 14.37 10.31 6 214741 82 90413618
Facial paresis 14.24 10.31 30 214717 3933 90409767
Cardioactive drug level above therapeutic 14.22 10.31 7 214740 143 90413557
Ketonuria 14.19 10.31 13 214734 768 90412932
Altered visual depth perception 14.16 10.31 10 214737 406 90413294
External ear disorder 14.13 10.31 5 214742 42 90413658
Premature labour 14.13 10.31 7 214740 13369 90400331
Spinal disorder 14.12 10.31 5 214742 11674 90402026
Skin ulcer 14.10 10.31 181 214566 49894 90363806
Compartment syndrome 14.08 10.31 25 214722 2887 90410813
Cardio-respiratory arrest 14.07 10.31 219 214528 62921 90350779
Anticoagulation drug level increased 14.05 10.31 9 214738 310 90413390
Suicide attempt 14.04 10.31 254 214493 75145 90338555
Mucosal membrane hyperplasia 14.03 10.31 5 214742 43 90413657
Platelet count decreased 14.02 10.31 234 214513 136735 90276965
Autoimmune thyroiditis 14.01 10.31 38 214709 5855 90407845
Humerus fracture 14.01 10.31 53 214694 9732 90403968
Left ventricular hypertrophy 13.99 10.31 39 214708 6105 90407595
Gastrointestinal ulcer haemorrhage 13.99 10.31 14 214733 924 90412776
Postoperative wound infection 13.98 10.31 66 214681 13360 90400340
Brain contusion 13.94 10.31 12 214735 653 90413047
Intra-abdominal haematoma 13.88 10.31 21 214726 2123 90411577
Device breakage 13.88 10.31 8 214739 14036 90399664
Pulmonary vein occlusion 13.86 10.31 6 214741 90 90413610
Defect conduction intraventricular 13.85 10.31 8 214739 228 90413472
Renal phospholipidosis 13.85 10.31 8 214739 228 90413472
Heart rate increased 13.84 10.31 358 214389 112544 90301156
Gamma-glutamyltransferase abnormal 13.82 10.31 11 214736 536 90413164
Wrong technique in product usage process 13.79 10.31 106 214641 71465 90342235
Chest wall haematoma 13.75 10.31 8 214739 231 90413469
Renal infarct 13.70 10.31 18 214729 1597 90412103
Burns second degree 13.69 10.31 20 214727 1960 90411740
Stupor 13.69 10.31 36 214711 5446 90408254
Wrong dose 13.66 10.31 20 214727 1964 90411736
Chromaturia 13.66 10.31 85 214662 19102 90394598
Drug therapeutic incompatibility 13.64 10.31 5 214742 47 90413653
Intestinal intraepithelial lymphocytes increased 13.60 10.31 4 214743 17 90413683
Blood potassium increased 13.59 10.31 90 214657 20659 90393041
Tenderness 13.51 10.31 27 214720 26841 90386859
Resuscitation 13.48 10.31 16 214731 1280 90412420
Intermittent claudication 13.46 10.31 19 214728 1804 90411896
Blood thyroid stimulating hormone increased 13.45 10.31 50 214697 9105 90404595
Activated partial thromboplastin time prolonged 13.44 10.31 45 214702 7780 90405920
Peripheral artery thrombosis 13.40 10.31 21 214726 2189 90411511
Lupus nephritis 13.38 10.31 33 214714 4799 90408901
Thrombotic thrombocytopenic purpura 13.36 10.31 30 214717 4108 90409592
Urinary incontinence 13.34 10.31 142 214605 37424 90376276
Proctitis 13.31 10.31 10 214737 15249 90398451
Abdominal wall haemorrhage 13.27 10.31 7 214740 166 90413534
Herpes zoster 13.16 10.31 152 214595 94492 90319208
Foot fracture 13.15 10.31 27 214720 26579 90387121
Ventricular dysfunction 13.12 10.31 28 214719 3703 90409997
Angiocardiogram 13.11 10.31 5 214742 53 90413647
Chronic gastritis 13.07 10.31 28 214719 3713 90409987
Anal paraesthesia 13.07 10.31 4 214743 20 90413680
Cardiac valve fibroelastoma 13.07 10.31 3 214744 3 90413697
Gastric atony 13.07 10.31 3 214744 3 90413697
Small fibre neuropathy 13.06 10.31 12 214735 712 90412988
Psychomotor skills impaired 13.05 10.31 24 214723 2848 90410852
Ocular hyperaemia 13.03 10.31 39 214708 33759 90379941
Osteocalcin decreased 13.03 10.31 5 214742 54 90413646
Immune-mediated lung disease 13.01 10.31 19 214728 1861 90411839
Blindness cortical 13.01 10.31 11 214736 584 90413116
Systolic hypertension 12.98 10.31 11 214736 586 90413114
Renin decreased 12.98 10.31 6 214741 106 90413594
Rhinorrhoea 12.94 10.31 287 214460 88029 90325671
Urogenital haemorrhage 12.93 10.31 8 214739 259 90413441
Degenerative mitral valve disease 12.91 10.31 4 214743 21 90413679
Superinfection 12.90 10.31 25 214722 3087 90410613
Daydreaming 12.90 10.31 10 214737 469 90413231
Cardiac aneurysm 12.87 10.31 14 214733 1018 90412682
Discoloured vomit 12.87 10.31 15 214732 1177 90412523
Brain injury 12.85 10.31 44 214703 7694 90406006
Eye injury 12.85 10.31 5 214742 11015 90402685
Hypercapnic coma 12.77 10.31 8 214739 265 90413435
Postural tremor 12.77 10.31 10 214737 476 90413224
Sleep apnoea syndrome 12.70 10.31 36 214711 31711 90381989
Trifascicular block 12.68 10.31 6 214741 112 90413588
Coloboma 12.68 10.31 6 214741 112 90413588
Synovial cyst 12.64 10.31 6 214741 11746 90401954
XIth nerve injury 12.63 10.31 5 214742 59 90413641
Cheyne-Stokes respiration 12.63 10.31 6 214741 113 90413587
Small for dates baby 12.62 10.31 33 214714 4974 90408726
Compensatory sweating 12.61 10.31 4 214743 23 90413677
Atrial enlargement 12.60 10.31 9 214738 372 90413328
Degenerative aortic valve disease 12.59 10.31 7 214740 185 90413515
Limb discomfort 12.56 10.31 47 214700 38013 90375687
Malignant melanoma 12.50 10.31 61 214686 12515 90401185
Adrenomegaly 12.49 10.31 6 214741 116 90413584
Tracheal pain 12.48 10.31 5 214742 61 90413639
Pulseless electrical activity 12.47 10.31 48 214699 8884 90404816
Acquired haemophilia 12.47 10.31 14 214733 1055 90412645
Foot operation 12.45 10.31 3 214744 8998 90404702
Rhonchi 12.44 10.31 24 214723 2954 90410746
Neoplasm malignant 12.42 10.31 40 214707 33840 90379860
Paroxysmal arrhythmia 12.41 10.31 5 214742 62 90413638
Spur cell anaemia 12.41 10.31 5 214742 62 90413638
Left atrial volume increased 12.41 10.31 5 214742 62 90413638
Carotid arteriosclerosis 12.39 10.31 15 214732 1225 90412475
Necrotising fasciitis 12.38 10.31 28 214719 3852 90409848
Brief psychotic disorder with marked stressors 12.34 10.31 5 214742 63 90413637
Exposure keratitis 12.34 10.31 5 214742 63 90413637
Genital paraesthesia 12.33 10.31 4 214743 25 90413675
Genital herpes zoster 12.33 10.31 4 214743 25 90413675
Hypochromic anaemia 12.30 10.31 20 214727 2151 90411549
Serratia infection 12.30 10.31 14 214733 1071 90412629
Atypical fracture 12.27 10.31 13 214734 918 90412782
Feeling jittery 12.25 10.31 11 214736 15360 90398340
Amnesia 12.24 10.31 182 214565 108323 90305377
Granuloma skin 12.24 10.31 54 214693 10626 90403074
Ligament sprain 12.18 10.31 10 214737 14589 90399111
Ligament injury 12.15 10.31 14 214733 1085 90412615
Hypovolaemia 12.15 10.31 60 214687 12371 90401329
Red blood cell sedimentation rate increased 12.13 10.31 131 214616 82464 90331236
Eosinophil cationic protein increased 12.13 10.31 5 214742 66 90413634
Congestive hepatopathy 12.13 10.31 24 214723 3009 90410691
Coma acidotic 12.12 10.31 6 214741 124 90413576
Abdominal pain lower 12.12 10.31 117 214630 30060 90383640
Hepatic fibrosis 12.08 10.31 29 214718 4146 90409554
Parapsoriasis 12.08 10.31 6 214741 125 90413575
Premature delivery 12.07 10.31 49 214698 38713 90374987
Skin pressure mark 12.06 10.31 4 214743 27 90413673
Ultrasound uterus abnormal 12.06 10.31 5 214742 67 90413633
Peritoneal perforation 12.04 10.31 6 214741 126 90413574
Splenic haematoma 12.04 10.31 6 214741 126 90413574
Pyroglutamic acidosis 12.01 10.31 15 214732 1265 90412435
Hormone receptor positive HER2 negative breast cancer 11.98 10.31 8 214739 296 90413404
Rotator cuff syndrome 11.98 10.31 12 214735 15907 90397793
Haemorrhoids 11.97 10.31 106 214641 26596 90387104
Genital candidiasis 11.94 10.31 7 214740 205 90413495
Page kidney 11.94 10.31 4 214743 28 90413672
Vascular stenosis 11.91 10.31 10 214737 526 90413174
Concomitant disease progression 11.89 10.31 20 214727 2212 90411488
Small intestinal obstruction 11.87 10.31 20 214727 21214 90392486
Pleuritic pain 11.78 10.31 5 214742 10456 90403244
Depressed level of consciousness 11.78 10.31 240 214507 72544 90341156
Skull fracture 11.78 10.31 15 214732 1290 90412410
Kidney malformation 11.74 10.31 6 214741 133 90413567
Thoracic vertebral fracture 11.74 10.31 34 214713 5440 90408260
Colitis ulcerative 11.73 10.31 89 214658 60177 90353523
Urinary hesitation 11.73 10.31 21 214726 2442 90411258
Swollen tongue 11.65 10.31 163 214584 45793 90367907
Cerebral ventricular rupture 11.64 10.31 7 214740 215 90413485
Aspartate aminotransferase increased 11.64 10.31 323 214424 102614 90311086
Pericardial haemorrhage 11.62 10.31 18 214729 1858 90411842
Ventricular dyssynchrony 11.61 10.31 5 214742 74 90413626
Red blood cell sedimentation rate abnormal 11.60 10.31 25 214722 24179 90389521
Prothrombin time shortened 11.59 10.31 20 214727 2258 90411442
Gastrointestinal polyp haemorrhage 11.59 10.31 9 214738 423 90413277
Gastroenteritis 11.58 10.31 113 214634 29116 90384584
Pyramidal tract syndrome 11.54 10.31 10 214737 549 90413151
Infusion site extravasation 11.53 10.31 5 214742 10323 90403377
Congenital hydronephrosis 11.52 10.31 9 214738 427 90413273
Follicular lymphoma stage IV 11.48 10.31 4 214743 32 90413668
Adjusted calcium decreased 11.47 10.31 7 214740 221 90413479
Ischaemia 11.46 10.31 33 214714 5262 90408438
Paraparesis 11.45 10.31 23 214724 2915 90410785
International normalised ratio abnormal 11.44 10.31 27 214720 3818 90409882
Peripheral artery occlusion 11.41 10.31 16 214731 1510 90412190
Hyperbilirubinaemia 11.37 10.31 64 214683 13872 90399828
Renal cyst ruptured 11.37 10.31 4 214743 33 90413667
Thrombophlebitis 11.34 10.31 31 214716 4797 90408903
Vertebrobasilar insufficiency 11.33 10.31 7 214740 226 90413474
Bile duct stone 11.32 10.31 28 214719 4079 90409621
Product contamination 11.31 10.31 14 214733 1170 90412530
Mitral valve stenosis 11.30 10.31 15 214732 1344 90412356
Apathy 11.30 10.31 54 214693 10986 90402714
Sputum culture 11.30 10.31 8 214739 326 90413374
Gastric ulcer perforation 11.29 10.31 15 214732 1345 90412355
Eosinophilic cellulitis 11.22 10.31 7 214740 230 90413470
Drug dependence 11.19 10.31 34 214713 29293 90384407
Cholecystectomy 11.19 10.31 7 214740 11748 90401952
Vaginal discharge 11.19 10.31 18 214729 19446 90394254
Eastern Cooperative Oncology Group performance status worsened 11.17 10.31 18 214729 1921 90411779
Duodenal ulcer haemorrhage 11.17 10.31 21 214726 2535 90411165
Systolic anterior motion of mitral valve 11.16 10.31 4 214743 35 90413665
Product substitution issue 11.13 10.31 77 214670 17931 90395769
Cholecystitis acute 11.12 10.31 48 214699 9356 90404344
C-reactive protein increased 11.10 10.31 336 214411 181053 90232647
Aortic valve sclerosis 11.07 10.31 14 214733 1196 90412504
Strangulated hernia 11.07 10.31 4 214743 36 90413664
Hepatic necrosis 11.04 10.31 37 214710 6401 90407299
Blood creatine increased 11.04 10.31 39 214708 6928 90406772
Prinzmetal angina 11.03 10.31 13 214734 1032 90412668
Hyperleukocytosis 11.01 10.31 12 214735 875 90412825
Carbohydrate metabolism disorder 11.01 10.31 3 214744 9 90413691
Blood lactate dehydrogenase 11.01 10.31 3 214744 9 90413691
Product substitution error 10.97 10.31 4 214743 37 90413663
Device leakage 10.90 10.31 5 214742 9986 90403714
Neutropenic sepsis 10.90 10.31 77 214670 18053 90395647
Blood creatine phosphokinase MM increased 10.87 10.31 4 214743 38 90413662
Caesarean section 10.85 10.31 17 214730 18560 90395140
Thrombosis 10.83 10.31 116 214631 73135 90340565
Supraventricular tachyarrhythmia 10.83 10.31 5 214742 88 90413612
Gastroduodenal haemorrhage 10.83 10.31 5 214742 88 90413612
Sensory level abnormal 10.81 10.31 6 214741 158 90413542
Oesophagitis 10.80 10.31 74 214673 17175 90396525
Hypercreatininaemia 10.79 10.31 11 214736 742 90412958
Tendon rupture 10.79 10.31 47 214700 9196 90404504
Intestinal villi atrophy 10.76 10.31 8 214739 352 90413348
Parkinsonian rest tremor 10.74 10.31 6 214741 160 90413540
Viral infection 10.72 10.31 56 214691 41358 90372342
Exposure via skin contact 10.72 10.31 6 214741 10699 90403001
Cardiac murmur functional 10.69 10.31 4 214743 40 90413660
Neutrophil count decreased 10.69 10.31 113 214634 71419 90342281
Freezing phenomenon 10.69 10.31 17 214730 1795 90411905
Normochromic anaemia 10.68 10.31 8 214739 356 90413344
Protrusion tongue 10.66 10.31 8 214739 357 90413343
Dermatitis atopic 10.63 10.31 25 214722 23447 90390253
Loss of control of legs 10.54 10.31 15 214732 1435 90412265
Chronic obstructive pulmonary disease 10.52 10.31 239 214508 73590 90340110
Angiotensin converting enzyme inhibitor foetopathy 10.52 10.31 4 214743 42 90413658
Poisoning deliberate 10.49 10.31 71 214676 16415 90397285
Nerve compression 10.47 10.31 6 214741 10560 90403140
Clostridium difficile colitis 10.46 10.31 103 214644 26603 90387097
Nephrogenic anaemia 10.45 10.31 20 214727 2446 90411254
Food refusal 10.45 10.31 10 214737 625 90413075
Parkinsonism 10.45 10.31 63 214684 14002 90399698
Secretion discharge 10.44 10.31 69 214678 15827 90397873
Heart valve incompetence 10.44 10.31 24 214723 3338 90410362
Haematocrit abnormal 10.43 10.31 13 214734 1094 90412606
Sedation 10.42 10.31 69 214678 48102 90365598
Hypoproteinaemia 10.39 10.31 23 214724 3119 90410581
Dermatitis exfoliative generalised 10.36 10.31 33 214714 5560 90408140
Hypoaesthesia teeth 10.35 10.31 4 214743 44 90413656
Urine viscosity increased 10.35 10.31 4 214743 44 90413656
Small intestinal haemorrhage 10.35 10.31 19 214728 2252 90411448
Product contamination chemical 10.34 10.31 3 214744 12 90413688
Head and neck cancer metastatic 10.34 10.31 3 214744 12 90413688
Cutaneous vasculitis 10.33 10.31 39 214708 7154 90406546

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 1025.05 11.12 4133 212994 363204 42041004
Cardiac failure 856.61 11.12 1763 215364 105093 42299115
Bradycardia 830.80 11.12 1530 215597 83954 42320254
Drug ineffective 606.34 11.12 1461 215666 628736 41775472
Hyperkalaemia 550.84 11.12 1246 215881 79212 42324996
Drug interaction 507.29 11.12 2688 214439 264311 42139897
Death 504.99 11.12 1028 216099 470157 41934051
Atrial fibrillation 440.15 11.12 1636 215491 137957 42266251
Off label use 409.17 11.12 1772 215355 636563 41767645
Product dose omission issue 353.83 11.12 172 216955 154193 42250015
Hypotension 322.78 11.12 2331 214796 255300 42148908
Melaena 300.14 11.12 631 216496 38115 42366093
Syncope 295.64 11.12 1144 215983 98262 42305946
General physical health deterioration 283.85 11.12 1519 215608 149727 42254481
Completed suicide 281.54 11.12 72 217055 96393 42307815
Cardiac failure chronic 254.09 11.12 278 216849 9323 42394885
Ventricular tachycardia 247.46 11.12 503 216624 29657 42374551
Lactic acidosis 244.33 11.12 640 216487 44621 42359587
Dyspnoea 226.27 11.12 3331 213796 439290 41964918
Disease progression 223.70 11.12 241 216886 143415 42260793
Mitral valve incompetence 204.30 11.12 329 216798 16160 42388048
Angina pectoris 193.97 11.12 481 216646 32415 42371793
Arrhythmia 190.56 11.12 543 216584 39774 42364434
Haematuria 187.31 11.12 684 216443 57115 42347093
Sinus bradycardia 186.27 11.12 298 216829 14555 42389653
Systemic infection 179.91 11.12 174 216953 5031 42399177
Ejection fraction decreased 178.37 11.12 366 216761 21721 42382487
Dyspnoea exertional 174.94 11.12 608 216519 49540 42354668
Neuropathy peripheral 174.50 11.12 157 216970 101696 42302512
Oedema peripheral 171.51 11.12 1234 215893 134842 42269366
Cerebral haemorrhage 170.91 11.12 511 216616 38455 42365753
International normalised ratio increased 170.64 11.12 587 216540 47581 42356627
Drug abuse 169.55 11.12 170 216957 104601 42299607
N-terminal prohormone brain natriuretic peptide increased 168.02 11.12 140 216987 3313 42400895
Labelled drug-drug interaction medication error 167.82 11.12 292 216835 15290 42388918
Rectal haemorrhage 162.37 11.12 589 216538 49017 42355191
Left ventricular dysfunction 157.08 11.12 240 216887 11261 42392947
White blood cell count decreased 156.96 11.12 199 216928 110197 42294011
Product use in unapproved indication 155.24 11.12 455 216672 184001 42220207
Shock haemorrhagic 154.04 11.12 288 216839 15954 42388254
Orthostatic hypotension 151.59 11.12 419 216708 30151 42374057
Toxicity to various agents 150.05 11.12 629 216498 228507 42175701
Febrile neutropenia 149.18 11.12 468 216659 185235 42218973
Dyspnoea at rest 143.03 11.12 140 216987 4109 42400099
Ischaemic stroke 140.57 11.12 334 216793 21899 42382309
Hospitalisation 131.62 11.12 111 217016 74219 42329989
Electrocardiogram abnormal 130.59 11.12 206 216921 9939 42394269
Rales 129.82 11.12 219 216908 11181 42393027
Palpitations 128.98 11.12 557 216570 50240 42353968
Presyncope 127.41 11.12 323 216804 22064 42382144
Renal impairment 126.56 11.12 978 216149 109250 42294958
Atrial tachycardia 125.74 11.12 129 216998 4011 42400197
Diastolic dysfunction 125.32 11.12 166 216961 6817 42397391
Anaemia 124.96 11.12 2063 215064 278215 42125993
Atrioventricular block 123.43 11.12 195 216932 9420 42394788
Treatment failure 123.06 11.12 84 217043 62540 42341668
Injection site pain 122.57 11.12 71 217056 57727 42346481
Mental status changes 121.74 11.12 32 217095 42083 42362125
Haematoma 116.78 11.12 361 216766 27662 42376546
Coronary artery stenosis 116.35 11.12 198 216929 10181 42394027
Drug hypersensitivity 114.38 11.12 207 216920 99182 42305026
Acute myocardial infarction 112.85 11.12 590 216537 57575 42346633
Subarachnoid haemorrhage 112.37 11.12 236 216891 14236 42389972
Rash 106.87 11.12 900 216227 276054 42128154
Ventricular hypokinesia 106.02 11.12 152 216975 6732 42397476
Nausea 104.76 11.12 1409 215718 395390 42008818
Fall 104.36 11.12 1726 215401 232794 42171414
No adverse event 101.33 11.12 36 217091 38985 42365223
Subdural haematoma 100.08 11.12 302 216825 22836 42381372
Rhabdomyolysis 99.61 11.12 710 216417 77309 42326899
Venous pressure jugular increased 99.34 11.12 57 217070 715 42403493
Brain natriuretic peptide increased 97.75 11.12 145 216982 6625 42397583
Platelet count decreased 97.19 11.12 370 216757 138211 42265997
Sinusitis 96.21 11.12 61 217066 47231 42356977
Atrioventricular block complete 96.13 11.12 192 216935 11172 42393036
Product use issue 94.57 11.12 153 216974 76598 42327610
Seizure 93.82 11.12 308 216819 120253 42283955
Interstitial lung disease 93.28 11.12 702 216425 77760 42326448
Cardiospasm 92.13 11.12 77 217050 1830 42402378
Drug ineffective for unapproved indication 91.92 11.12 61 217066 46102 42358106
Palmoplantar keratoderma 90.70 11.12 82 217045 2172 42402036
Pneumonia 87.02 11.12 1571 215556 420578 41983630
Pain 86.35 11.12 814 216313 244034 42160174
Circulatory collapse 86.26 11.12 291 216836 23345 42380863
Unevaluable event 85.08 11.12 34 217093 34254 42369954
Exercise tolerance decreased 84.84 11.12 128 216999 5938 42398270
Infusion related reaction 83.92 11.12 112 217015 60694 42343514
Upper respiratory tract infection 83.61 11.12 56 217071 42117 42362091
Hypertensive crisis 83.42 11.12 170 216957 10036 42394172
Wrong patient received product 83.29 11.12 97 217030 3486 42400722
Sopor 83.09 11.12 198 216929 13004 42391204
Acute coronary syndrome 82.01 11.12 212 216915 14653 42389555
Drug resistance 81.70 11.12 36 217091 34212 42369996
Myelosuppression 81.19 11.12 53 217074 40408 42363800
Ventricular enlargement 78.84 11.12 47 217080 636 42403572
Drug dependence 78.76 11.12 25 217102 29069 42375139
Congestive cardiomyopathy 77.67 11.12 151 216976 8613 42395595
Drug dispensed to wrong patient 76.95 11.12 42 217085 475 42403733
Confusional state 76.13 11.12 1238 215889 166359 42237849
Ventricular arrhythmia 76.02 11.12 124 217003 6155 42398053
Chest pain 74.69 11.12 1060 216067 138470 42265738
Full blood count decreased 73.67 11.12 9 217118 20551 42383657
Urogenital haemorrhage 73.19 11.12 46 217081 688 42403520
Right atrial hypertrophy 73.02 11.12 46 217081 691 42403517
Pulmonary function test abnormal 73.01 11.12 79 217048 2615 42401593
Pruritus genital 72.59 11.12 78 217049 2561 42401647
Hypomagnesaemia 71.99 11.12 312 216815 28176 42376032
Cerebral haematoma 70.94 11.12 113 217014 5497 42398711
Tension headache 70.46 11.12 87 217040 3327 42400881
Hypoxia 70.29 11.12 157 216970 69629 42334579
Hypoglycaemia 70.27 11.12 534 216593 59320 42344888
Bradyarrhythmia 69.98 11.12 77 217050 2598 42401610
Infection 69.94 11.12 313 216814 111755 42292453
Carotid artery occlusion 69.63 11.12 96 217031 4098 42400110
Electrolyte imbalance 69.11 11.12 218 216909 16883 42387325
Tricuspid valve incompetence 68.14 11.12 165 216962 10948 42393260
Hypokalaemia 67.65 11.12 609 216518 71112 42333096
Occult blood 67.64 11.12 49 217078 937 42403271
Electrocardiogram QT prolonged 66.29 11.12 445 216682 47500 42356708
Respiratory tract haemorrhage 66.23 11.12 56 217071 1353 42402855
Neutrophil count decreased 66.07 11.12 140 216987 63275 42340933
Bronchial wall thickening 65.88 11.12 55 217072 1305 42402903
Therapeutic product effect incomplete 65.56 11.12 167 216960 70772 42333436
Atrial flutter 65.27 11.12 215 216912 17036 42387172
Cerebral infarction 64.50 11.12 322 216805 30847 42373361
Orthopnoea 64.26 11.12 106 217021 5311 42398897
Therapeutic product effect decreased 63.89 11.12 63 217064 39087 42365121
Vertigo 63.59 11.12 344 216783 34003 42370205
Constipation 62.65 11.12 527 216600 161764 42242444
Accidental exposure to product 61.85 11.12 14 217113 20379 42383829
Inferior vena cava dilatation 61.44 11.12 43 217084 777 42403431
Immunisation 61.20 11.12 51 217076 1207 42403001
Sleep terror 61.09 11.12 75 217052 2851 42401357
Product prescribing error 60.72 11.12 279 216848 25833 42378375
Dizziness 60.49 11.12 1680 215447 247574 42156634
Therapeutic response decreased 59.89 11.12 60 217067 36952 42367256
Headache 59.41 11.12 860 216267 238509 42165699
Eosinophilia 59.22 11.12 327 216800 32572 42371636
Cardiac failure acute 59.01 11.12 178 216949 13455 42390753
Hyponatraemia 58.82 11.12 782 216345 100680 42303528
Ischaemic cardiomyopathy 58.56 11.12 113 217014 6409 42397799
Foetal exposure during pregnancy 58.56 11.12 94 217033 47217 42356991
Peripheral arterial occlusive disease 58.39 11.12 116 217011 6722 42397486
Ventricular extrasystoles 58.12 11.12 175 216952 13215 42390993
Thrombosis 57.53 11.12 169 216958 68342 42335866
Nasopharyngitis 57.09 11.12 227 216900 83769 42320439
Nephrolithiasis 57.01 11.12 62 217065 36768 42367440
Medication error 56.68 11.12 325 216802 32829 42371379
Haematochezia 56.03 11.12 498 216629 57938 42346270
Glomerular filtration rate decreased 55.04 11.12 196 216931 16155 42388053
Product monitoring error 54.43 11.12 88 217039 4335 42399873
Stomatitis 54.21 11.12 109 217018 50220 42353988
Facial pain 54.13 11.12 86 217041 4174 42400034
Upper gastrointestinal haemorrhage 53.76 11.12 300 216827 29999 42374209
Arthralgia 53.53 11.12 730 216397 204508 42199700
Vascular stent thrombosis 53.51 11.12 74 217053 3168 42401040
Incorrect dose administered 53.48 11.12 119 217008 52855 42351353
Hyperthyroidism 52.71 11.12 177 216950 14164 42390044
Left ventricular hypertrophy 52.54 11.12 134 216993 9185 42395023
Contraindicated product administered 52.23 11.12 261 216866 25011 42379197
Right ventricular hypertrophy 51.98 11.12 51 217076 1501 42402707
Malignant neoplasm progression 51.92 11.12 331 216796 108069 42296139
Bundle branch block left 51.90 11.12 107 217020 6369 42397839
Injection site erythema 51.80 11.12 19 217108 20176 42384032
Pemphigoid 51.79 11.12 152 216975 11315 42392893
Cardiac murmur 51.76 11.12 163 216964 12612 42391596
Duodenal ulcer haemorrhage 51.38 11.12 100 217027 5708 42398500
Nasal congestion 51.05 11.12 45 217082 29456 42374752
Therapy interrupted 50.58 11.12 25 217102 22225 42381983
Drug intolerance 50.54 11.12 224 216903 80200 42324008
Myoglobin blood increased 50.51 11.12 77 217050 3605 42400603
Oesophageal perforation 49.89 11.12 45 217082 1188 42403020
Aortic valve stenosis 49.73 11.12 69 217058 2963 42401245
Sepsis 49.49 11.12 716 216411 198618 42205590
Loss of consciousness 49.13 11.12 701 216426 91653 42312555
Therapy non-responder 49.00 11.12 126 217001 53233 42350975
Mucosal inflammation 48.96 11.12 112 217015 49262 42354946
Atrioventricular block second degree 48.42 11.12 81 217046 4106 42400102
Myocardial ischaemia 48.35 11.12 199 216928 17563 42386645
Systolic dysfunction 48.31 11.12 68 217059 2960 42401248
Graft versus host disease 47.96 11.12 5 217122 12920 42391288
Respiratory failure 47.68 11.12 420 216707 127712 42276496
Hemiparesis 47.55 11.12 195 216932 17181 42387027
Anuria 47.51 11.12 148 216979 11384 42392824
Renal failure 47.25 11.12 1010 216117 142716 42261492
Vascular purpura 47.21 11.12 57 217070 2129 42402079
Cardiovascular insufficiency 46.80 11.12 52 217075 1774 42402434
Normocytic anaemia 46.54 11.12 73 217054 3504 42400704
Therapy cessation 46.45 11.12 23 217104 20427 42383781
Cardiogenic shock 46.42 11.12 326 216801 35314 42368894
Blood creatinine increased 46.38 11.12 803 216324 109200 42295008
Minimum inhibitory concentration 46.35 11.12 21 217106 153 42404055
Lip swelling 46.11 11.12 206 216921 18847 42385361
Bronchial secretion retention 45.09 11.12 48 217079 1559 42402649
Antimicrobial susceptibility test resistant 45.06 11.12 27 217100 369 42403839
Atrial enlargement 45.00 11.12 34 217093 695 42403513
Abnormal behaviour 44.99 11.12 41 217086 26410 42377798
Respiratory symptom 44.77 11.12 3 217124 11103 42393105
Illness 44.39 11.12 37 217090 24893 42379315
Left atrial enlargement 44.32 11.12 39 217088 996 42403212
Jaundice 44.24 11.12 315 216812 34274 42369934
Fatigue 43.84 11.12 1795 215332 433846 41970362
Dehydration 43.35 11.12 986 216141 140781 42263427
Dermatitis atopic 43.07 11.12 6 217121 12398 42391810
Abdominal distension 41.99 11.12 205 216922 71530 42332678
Blood pressure systolic decreased 41.87 11.12 84 217043 4903 42399305
Metabolic acidosis 41.79 11.12 426 216701 51432 42352776
Hypocalcaemia 41.67 11.12 280 216847 29893 42374315
Degenerative mitral valve disease 41.40 11.12 23 217104 270 42403938
Appendicitis 41.35 11.12 27 217100 20586 42383622
Electrocardiogram PR prolongation 41.21 11.12 37 217090 971 42403237
Pathogen resistance 41.05 11.12 5 217122 11445 42392763
Drug withdrawal syndrome 40.88 11.12 30 217097 21519 42382689
Device leakage 40.82 11.12 3 217124 10282 42393926
Hepatojugular reflux 40.44 11.12 31 217096 648 42403560
Injection site swelling 40.23 11.12 18 217109 16955 42387253
Chronic kidney disease 39.96 11.12 392 216735 46849 42357359
Strangury 39.87 11.12 18 217109 130 42404078
Bacterial infection 39.85 11.12 50 217077 27829 42376379
Psoriatic arthropathy 39.79 11.12 41 217086 24926 42379282
Haematemesis 38.61 11.12 275 216852 29924 42374284
Influenza 38.56 11.12 174 216953 62001 42342207
Drug use disorder 38.34 11.12 4 217123 10329 42393879
Injection site reaction 38.33 11.12 16 217111 15705 42388503
Carotid arteriosclerosis 38.14 11.12 53 217074 2279 42401929
Transplant rejection 38.00 11.12 11 217116 13577 42390631
Cytokine release syndrome 37.98 11.12 109 217018 44418 42359790
Mitral valve thickening 37.91 11.12 26 217101 454 42403754
Leriche syndrome 37.77 11.12 16 217111 97 42404111
Irritability 37.60 11.12 53 217074 28075 42376133
Flushing 37.52 11.12 83 217044 36945 42367263
IVth nerve paralysis 37.45 11.12 28 217099 563 42403645
Pericardial haemorrhage 37.28 11.12 66 217061 3503 42400705
Left ventricular enlargement 36.93 11.12 32 217095 800 42403408
Neutropenia 36.39 11.12 757 216370 198674 42205534
Anosmia 36.28 11.12 81 217046 5095 42399113
Therapeutic response shortened 36.06 11.12 12 217115 13542 42390666
Toxic skin eruption 35.94 11.12 152 216975 13578 42390630
Viral infection 35.74 11.12 37 217090 22446 42381762
Chronic coronary syndrome 35.49 11.12 21 217106 280 42403928
Electrocardiogram Q wave abnormal 35.41 11.12 26 217101 508 42403700
Gastritis erosive 35.11 11.12 92 217035 6411 42397797
Epistaxis 35.03 11.12 506 216621 66320 42337888
Fractional exhaled nitric oxide increased 34.82 11.12 42 217085 1567 42402641
Acute pulmonary oedema 34.70 11.12 110 217017 8541 42395667
Bacteraemia 34.66 11.12 46 217081 24994 42379214
Neuralgia 34.61 11.12 48 217079 25599 42378609
Back pain 34.55 11.12 511 216616 141265 42262943
Staphylococcal infection 34.47 11.12 89 217038 37554 42366654
ECG signs of myocardial ischaemia 34.29 11.12 18 217109 187 42404021
Aspergillus infection 34.21 11.12 19 217108 15818 42388390
Extremity necrosis 33.96 11.12 50 217077 2269 42401939
Jugular vein distension 33.83 11.12 28 217099 656 42403552
Product quality issue 33.78 11.12 25 217102 17857 42386351
Tachycardia 33.73 11.12 712 216415 100375 42303833
Intestinal haemorrhage 33.71 11.12 67 217060 3884 42400324
Multimorbidity 33.66 11.12 32 217095 905 42403303
Hypersensitivity 33.61 11.12 223 216904 72147 42332061
Cerebral ventricular rupture 33.33 11.12 18 217109 199 42404009
Intraventricular haemorrhage 33.30 11.12 66 217061 3818 42400390
Psoriasis 33.24 11.12 131 216996 48473 42355735
Therapy partial responder 32.91 11.12 32 217095 19989 42384219
Arthropathy 32.82 11.12 63 217064 29534 42374674
Pain of skin 32.64 11.12 103 217024 7977 42396231
Rheumatoid arthritis 32.58 11.12 109 217018 42331 42361877
Faeces discoloured 32.57 11.12 172 216955 16842 42387366
Carotid artery stenosis 32.57 11.12 80 217047 5356 42398852
Depression 32.37 11.12 387 216740 110976 42293232
Echocardiogram abnormal 32.26 11.12 36 217091 1234 42402974
Small intestinal obstruction 32.04 11.12 24 217103 17037 42387171
Hypovolaemic shock 31.93 11.12 107 217020 8552 42395656
Nodule 31.80 11.12 12 217115 12522 42391686
Pyrexia 31.67 11.12 1663 215464 392379 42011829
Pulmonary vascular disorder 31.63 11.12 27 217100 661 42403547
Product dose omission in error 31.61 11.12 3 217124 8351 42395857
Musculoskeletal stiffness 31.58 11.12 169 216958 57596 42346612
Duodenitis 31.43 11.12 80 217047 5476 42398732
Incorrect route of product administration 31.30 11.12 47 217080 24258 42379950
Blood glucose fluctuation 31.28 11.12 71 217056 4516 42399692
Febrile infection 31.24 11.12 53 217074 2718 42401490
Sedation 31.13 11.12 68 217059 30407 42373801
BK virus infection 31.09 11.12 4 217123 8780 42395428
Embolic stroke 31.08 11.12 75 217052 4965 42399243
Cardiac aneurysm 31.04 11.12 33 217094 1070 42403138
Device issue 30.97 11.12 15 217112 13494 42390714
Haematoma muscle 30.97 11.12 46 217081 2104 42402104
Gravitational oedema 30.96 11.12 27 217100 681 42403527
Psychotic disorder 30.82 11.12 64 217063 29144 42375064
Aortic valve incompetence 30.73 11.12 88 217039 6460 42397748
Torsade de pointes 30.64 11.12 105 217022 8489 42395719
Therapeutic response delayed 30.60 11.12 27 217100 692 42403516
Atrial thrombosis 30.59 11.12 49 217078 2395 42401813
Transient ischaemic attack 30.53 11.12 284 216843 33455 42370753
Synovitis 30.41 11.12 21 217106 15546 42388662
Stress 30.33 11.12 119 217008 44093 42360115
Gastrointestinal haemorrhage 30.26 11.12 681 216446 97045 42307163
Neurotoxicity 30.21 11.12 46 217081 23605 42380603
Inappropriate antidiuretic hormone secretion 30.16 11.12 165 216962 16376 42387832
Malaise 30.11 11.12 1345 215782 210811 42193397
Tremor 30.05 11.12 332 216795 96597 42307611
Disorientation 29.82 11.12 300 216827 36089 42368119
Fungal infection 29.64 11.12 34 217093 19688 42384520
Premature baby 29.60 11.12 45 217082 23108 42381100
Respiratory arrest 29.39 11.12 63 217064 28361 42375847
Increased appetite 29.35 11.12 5 217122 8901 42395307
Sinoatrial block 29.17 11.12 23 217104 502 42403706
Therapeutic response unexpected 28.70 11.12 11 217116 11370 42392838
Plasma cell myeloma 28.40 11.12 135 216992 47443 42356765
Joint injury 28.40 11.12 20 217107 14656 42389552
Cerebellar haemorrhage 28.35 11.12 39 217088 1661 42402547
Anxiety 28.30 11.12 429 216698 118131 42286077
Hypochromic anaemia 28.10 11.12 31 217096 1049 42403159
Tachyarrhythmia 28.09 11.12 62 217065 3870 42400338
Tongue oedema 28.08 11.12 56 217071 3254 42400954
Rash papular 28.05 11.12 127 217000 11684 42392524
Erysipelas 28.00 11.12 83 217044 6213 42397995
Soft tissue mass 27.99 11.12 30 217097 982 42403226
Surgery 27.99 11.12 29 217098 17587 42386621
Hypocoagulable state 27.97 11.12 30 217097 983 42403225
Product dispensing error 27.82 11.12 94 217033 7545 42396663
Injection site pruritus 27.45 11.12 7 217120 9398 42394810
Inflammatory marker increased 27.18 11.12 86 217041 6670 42397538
Pericarditis 27.18 11.12 138 216989 13306 42390902
Pallor 27.07 11.12 245 216882 28641 42375567
Cellulitis 27.00 11.12 193 216934 61392 42342816
Abdominal wall haematoma 26.96 11.12 45 217082 2277 42401931
Swollen tongue 26.94 11.12 193 216934 21038 42383170
Oropharyngeal pain 26.94 11.12 118 217009 42392 42361816
Blood creatine phosphokinase increased 26.93 11.12 370 216757 47968 42356240
Inappropriate schedule of product administration 26.83 11.12 336 216791 95566 42308642
Bone marrow failure 26.79 11.12 83 217044 33010 42371198
Chest X-ray abnormal 26.64 11.12 66 217061 4442 42399766
Osteonecrosis 26.49 11.12 25 217102 15840 42388368
Vascular stent stenosis 26.47 11.12 31 217096 1121 42403087
Cholestasis 26.44 11.12 270 216857 32609 42371599
Spinal cord haemorrhage 26.41 11.12 18 217109 311 42403897
Extrasystoles 26.35 11.12 63 217064 4146 42400062
Cytomegalovirus infection reactivation 26.26 11.12 12 217115 11166 42393042
Cardioactive drug level increased 26.23 11.12 38 217089 1699 42402509
Cytomegalovirus viraemia 26.22 11.12 10 217117 10367 42393841
Blood pressure decreased 26.09 11.12 430 216697 57902 42346306
Urticaria 26.08 11.12 246 216881 73790 42330418
Poisoning 25.94 11.12 22 217105 14677 42389531
Obstruction 25.73 11.12 52 217075 3051 42401157
Hypersomnia 25.65 11.12 22 217105 14596 42389612
Blood lactic acid 25.59 11.12 18 217109 328 42403880
Liver function test abnormal 25.57 11.12 265 216862 32126 42372082
Decreased appetite 25.50 11.12 769 216358 192368 42211840
Ear infection 25.37 11.12 17 217110 12787 42391421
Sleep disorder due to a general medical condition 25.26 11.12 31 217096 17422 42386786
Gastrointestinal disorder 25.22 11.12 137 216990 46516 42357692
Herpes zoster 25.19 11.12 107 217020 38770 42365438
Therapeutic drug monitoring analysis not performed 25.06 11.12 22 217105 560 42403648
Red cell distribution width increased 24.75 11.12 85 217042 6879 42397329
Injection site bruising 24.65 11.12 14 217113 11511 42392697
Nuchal rigidity 24.57 11.12 21 217106 515 42403693
International normalised ratio abnormal 24.48 11.12 54 217073 3369 42400839
Left ventricular failure 24.47 11.12 77 217050 5954 42398254
Blood test abnormal 24.44 11.12 18 217109 12888 42391320
Cystitis haemorrhagic 24.40 11.12 4 217123 7325 42396883
Chills 24.32 11.12 335 216792 93731 42310477
Escherichia infection 24.15 11.12 14 217113 11382 42392826
Haemarthrosis 24.12 11.12 59 217068 3939 42400269
Myasthenia gravis 24.06 11.12 28 217099 16109 42388099
Adrenal insufficiency 23.98 11.12 37 217090 18887 42385321
Burns second degree 23.98 11.12 77 217050 6019 42398189
Hypochromasia 23.97 11.12 17 217110 314 42403894
Myocardial infarction 23.90 11.12 813 216314 123196 42281012
Spleen ischaemia 23.69 11.12 10 217117 60 42404148
Epstein-Barr virus infection 23.52 11.12 10 217117 9708 42394500
Multiple sclerosis 23.48 11.12 5 217122 7593 42396615
Cardiac amyloidosis 23.47 11.12 39 217088 1966 42402242
Renal injury 23.41 11.12 17 217110 12263 42391945
C-reactive protein abnormal 23.27 11.12 9 217118 9252 42394956
Cardiac septal hypertrophy 23.21 11.12 18 217109 383 42403825
Neck pain 23.09 11.12 77 217050 29937 42374271
Myelodysplastic syndrome 23.03 11.12 51 217076 22694 42381514
Head titubation 22.79 11.12 19 217108 450 42403758
Peripheral artery bypass 22.65 11.12 10 217117 68 42404140
Hypokinesia 22.60 11.12 105 217022 9766 42394442
Subdural haemorrhage 22.56 11.12 53 217074 3448 42400760
Condition aggravated 22.53 11.12 1092 216035 259662 42144546
Sensation of foreign body 22.53 11.12 54 217073 3559 42400649
Transferrin saturation decreased 22.43 11.12 20 217107 520 42403688
Blood cholesterol increased 22.41 11.12 66 217061 26675 42377533
Tendon rupture 22.34 11.12 91 217036 7992 42396216
Dyslipidaemia 22.17 11.12 101 217026 9317 42394891
Syringe issue 22.03 11.12 8 217119 8548 42395660
Cold sweat 22.00 11.12 115 217012 11215 42392993
Respiratory depression 21.95 11.12 39 217088 18829 42385379
Muscle haemorrhage 21.90 11.12 58 217069 4067 42400141
Peripheral artery stenosis 21.83 11.12 25 217102 882 42403326
Heart sounds abnormal 21.76 11.12 25 217102 885 42403323
Histamine level increased 21.72 11.12 10 217117 76 42404132
Leukocytosis 21.65 11.12 78 217049 29630 42374578
Sinus disorder 21.64 11.12 7 217120 8043 42396165
Tumour lysis syndrome 21.57 11.12 51 217076 22180 42382028
Ventricular hyperkinesia 21.46 11.12 14 217113 224 42403984
Angina unstable 21.41 11.12 115 217012 11333 42392875
Adrenal cyst 21.36 11.12 13 217114 183 42404025
Localised infection 21.19 11.12 45 217082 20328 42383880
Tinnitus 21.09 11.12 233 216894 28705 42375503
Influenza like illness 21.02 11.12 87 217040 31753 42372455
Bronchopulmonary aspergillosis 20.98 11.12 42 217085 19387 42384821
Aspartate aminotransferase increased 20.97 11.12 272 216855 76891 42327317
Blood thyroid stimulating hormone increased 20.96 11.12 67 217060 5225 42398983
Helicobacter gastritis 20.95 11.12 30 217097 1327 42402881
Haemophagocytic lymphohistiocytosis 20.90 11.12 38 217089 18184 42386024
Nightmare 20.88 11.12 207 216920 24805 42379403
Rhinovirus infection 20.88 11.12 4 217123 6544 42397664
Emotional distress 20.84 11.12 31 217096 16062 42388146
Swelling 20.80 11.12 179 216948 54706 42349502
Hypogammaglobulinaemia 20.74 11.12 18 217109 11873 42392335
Peripheral artery occlusion 20.68 11.12 35 217092 1791 42402417
Acute graft versus host disease 20.62 11.12 8 217119 8207 42396001
Superinfection 20.48 11.12 46 217081 2905 42401303
Ischaemic nephropathy 20.47 11.12 10 217117 88 42404120
Angioedema 20.45 11.12 317 216810 42160 42362048
Monoparesis 20.39 11.12 46 217081 2914 42401294
Bleeding time prolonged 20.36 11.12 21 217106 657 42403551
Plantar fasciitis 20.36 11.12 47 217080 3023 42401185
Cardiac dysfunction 20.34 11.12 50 217077 3349 42400859
Traumatic intracranial haemorrhage 20.34 11.12 22 217105 728 42403480
Deep vein thrombosis 20.28 11.12 273 216854 76684 42327524
Paranoia 20.20 11.12 25 217102 14001 42390207
Cerebellar haematoma 20.20 11.12 13 217114 203 42404005
Left ventricular dilatation 20.18 11.12 24 217103 882 42403326
Drug dose omission by device 20.08 11.12 3 217124 5883 42398325
Acne 19.99 11.12 24 217103 13620 42390588
Nicotine dependence 19.98 11.12 21 217106 672 42403536
Anhedonia 19.91 11.12 7 217120 7633 42396575
Hyperkaliuria 19.91 11.12 10 217117 94 42404114
Cardioversion 19.84 11.12 25 217102 976 42403232
Knee arthroplasty 19.76 11.12 10 217117 8771 42395437
Vascular pseudoaneurysm 19.64 11.12 43 217084 2669 42401539
Full blood count abnormal 19.50 11.12 82 217045 29794 42374414
Granulocytopenia 19.45 11.12 6 217121 7108 42397100
Hepatic vein dilatation 19.41 11.12 13 217114 218 42403990
Back disorder 19.39 11.12 7 217120 7507 42396701
Neoplasm progression 19.29 11.12 79 217048 28921 42375287
Intracranial haematoma 19.29 11.12 19 217108 562 42403646
Drug effective for unapproved indication 19.24 11.12 5 217122 6628 42397580
Postrenal failure 19.23 11.12 19 217108 564 42403644
Procalcitonin abnormal 19.19 11.12 16 217111 379 42403829
Blood glucose abnormal 19.18 11.12 79 217048 6974 42397234
Disease recurrence 19.03 11.12 82 217045 29596 42374612
Agranulocytosis 19.00 11.12 239 216888 30373 42373835
Multiple organ dysfunction syndrome 18.97 11.12 364 216763 96671 42307537
Hallucination, auditory 18.89 11.12 29 217098 14835 42389373
Anaemia macrocytic 18.89 11.12 50 217077 3505 42400703
Endocarditis 18.87 11.12 87 217040 8065 42396143
Exposure during pregnancy 18.84 11.12 10 217117 8538 42395670
Rebound effect 18.83 11.12 7 217120 7372 42396836
Unresponsive to stimuli 18.80 11.12 89 217038 31314 42372894
Abnormal loss of weight 18.72 11.12 62 217065 4925 42399283
Heart rate irregular 18.71 11.12 143 216984 15907 42388301
Renal phospholipidosis 18.70 11.12 11 217116 145 42404063
Laryngeal discomfort 18.66 11.12 13 217114 233 42403975
Haemorrhagic stroke 18.64 11.12 81 217046 7321 42396887
Helicobacter test positive 18.64 11.12 22 217105 802 42403406
Cardiomyopathy 18.55 11.12 164 216963 19046 42385162
Immune thrombocytopenia 18.55 11.12 109 217018 11107 42393101
Brain stem infarction 18.51 11.12 28 217099 1302 42402906
Platelet distribution width decreased 18.49 11.12 7 217120 30 42404178
Glycosylated haemoglobin increased 18.48 11.12 121 217006 12803 42391405
Ulnar nerve injury 18.48 11.12 10 217117 111 42404097
Mechanical urticaria 18.40 11.12 10 217117 112 42404096
Hepatotoxicity 18.39 11.12 66 217061 25101 42379107
Platelet distribution width increased 18.38 11.12 11 217116 150 42404058
Stenosis 18.37 11.12 36 217091 2065 42402143
Shock 18.35 11.12 228 216899 28893 42375315
Steatorrhoea 18.32 11.12 22 217105 817 42403391
Vision blurred 18.24 11.12 180 216947 53519 42350689
Retinal artery occlusion 18.22 11.12 37 217090 2178 42402030
Crying 18.21 11.12 5 217122 6389 42397819
Disability 18.14 11.12 4 217123 5929 42398279
Prostate cancer 18.09 11.12 143 216984 44500 42359708
Subcutaneous haematoma 18.08 11.12 25 217102 1070 42403138
Base excess decreased 18.08 11.12 12 217115 198 42404010
Electrocardiogram T wave inversion 18.04 11.12 38 217089 2296 42401912
Eye injury 18.03 11.12 24 217103 990 42403218
Tuberculosis 17.96 11.12 15 217112 10084 42394124
Muscle twitching 17.90 11.12 112 217015 11668 42392540
Hyperphosphataemia 17.88 11.12 24 217103 12980 42391228
Polymerase chain reaction 17.88 11.12 9 217118 85 42404123
Insomnia 17.86 11.12 462 216665 117791 42286417
Hyperuricaemia 17.85 11.12 95 217032 9329 42394879
Haemothorax 17.82 11.12 63 217064 5173 42399035
Gastric ischaemia 17.81 11.12 8 217119 57 42404151
Haemorrhage intracranial 17.77 11.12 149 216978 17043 42387165
Poisoning deliberate 17.75 11.12 100 217027 10034 42394174
Genital herpes simplex 17.74 11.12 10 217117 121 42404087
Osteopenia 17.71 11.12 5 217122 6273 42397935
Pulmonary vasculitis 17.65 11.12 5 217122 6261 42397947
Xyphoid retraction 17.65 11.12 11 217116 162 42404046
Ejection fraction abnormal 17.65 11.12 27 217100 1268 42402940
Laboratory test abnormal 17.64 11.12 59 217068 22919 42381289
Hyperammonaemia 17.63 11.12 9 217118 7857 42396351
Diverticulum intestinal haemorrhagic 17.63 11.12 44 217083 2975 42401233
Colitis microscopic 17.61 11.12 45 217082 3088 42401120
Duodenal ulcer 17.59 11.12 115 217012 12164 42392044
Atelectasis 17.55 11.12 46 217081 19315 42384893
Subacute cutaneous lupus erythematosus 17.49 11.12 29 217098 1459 42402749
Vertebrobasilar insufficiency 17.46 11.12 10 217117 125 42404083
Neuritis 17.46 11.12 5 217122 6215 42397993
Intestinal obstruction 17.44 11.12 75 217052 27083 42377125
Substance abuse 17.41 11.12 12 217115 8893 42395315
Benign gastrointestinal neoplasm 17.39 11.12 10 217117 126 42404082
Suspected suicide 17.37 11.12 5 217122 6194 42398014
Concomitant disease progression 17.35 11.12 39 217088 2464 42401744
Sinus node dysfunction 17.34 11.12 59 217068 4753 42399455
Vasospasm 17.33 11.12 18 217109 568 42403640
Blood potassium increased 17.26 11.12 157 216970 18379 42385829
Skin pressure mark 17.24 11.12 8 217119 62 42404146
Dry eye 17.19 11.12 33 217094 15473 42388735
Atrioventricular block first degree 17.10 11.12 72 217055 6419 42397789
Hyperlipasaemia 17.05 11.12 18 217109 579 42403629
Hepatic function abnormal 17.04 11.12 174 216953 51393 42352815
Catarrh 17.03 11.12 68 217059 5918 42398290
Eye pruritus 17.03 11.12 108 217019 11304 42392904
Adenomatous polyposis coli 17.03 11.12 11 217116 173 42404035
Venous pressure jugular decreased 17.01 11.12 7 217120 39 42404169
Graft versus host disease in skin 17.01 11.12 3 217124 5209 42398999
Pneumonia fungal 17.00 11.12 13 217114 9133 42395075
Systemic lupus erythematosus 16.99 11.12 93 217034 9231 42394977
Dyspnoea paroxysmal nocturnal 16.97 11.12 30 217097 1590 42402618
Rash maculo-papular 16.97 11.12 277 216850 37226 42366982
Immune reconstitution inflammatory syndrome 16.92 11.12 16 217111 10127 42394081
Staphylococcal bacteraemia 16.90 11.12 19 217108 11102 42393106
Purpura 16.86 11.12 111 217016 11768 42392440
Akathisia 16.84 11.12 17 217110 10434 42393774
Right atrial enlargement 16.83 11.12 13 217114 275 42403933
Injection site haemorrhage 16.82 11.12 21 217106 11715 42392493
Amnesia 16.80 11.12 220 216907 28217 42375991
Extradural haematoma 16.79 11.12 27 217100 1324 42402884
Small for dates baby 16.79 11.12 62 217065 5201 42399007
Troponin T increased 16.75 11.12 41 217086 2739 42401469
Osteomyelitis 16.75 11.12 43 217084 18180 42386028
Hemiataxia 16.59 11.12 7 217120 42 42404166
Hypertensive heart disease 16.56 11.12 39 217088 2541 42401667
Melanoderma 16.55 11.12 11 217116 182 42404026
Treatment noncompliance 16.54 11.12 118 217009 37554 42366654
Steroid dependence 16.51 11.12 73 217054 6649 42397559
Haemoglobin urine present 16.48 11.12 10 217117 140 42404068
Encephalopathy 16.47 11.12 133 216994 41200 42363008
Wound 16.46 11.12 146 216981 16971 42387237
Haematotoxicity 16.44 11.12 19 217108 10966 42393242
Intentional dose omission 16.42 11.12 13 217114 8973 42395235
Product administration error 16.39 11.12 154 216973 18189 42386019
Blood loss anaemia 16.35 11.12 95 217032 9641 42394567
Acquired haemophilia 16.25 11.12 30 217097 1645 42402563
Mean cell haemoglobin increased 16.25 11.12 35 217092 2148 42402060
Obsessive-compulsive disorder 16.22 11.12 7 217120 6736 42397472
Thalamus haemorrhage 16.20 11.12 24 217103 1095 42403113
Lipoprotein (a) increased 16.16 11.12 14 217113 350 42403858
Basilar artery thrombosis 16.15 11.12 12 217115 239 42403969
Needle fatigue 16.12 11.12 25 217102 1188 42403020
C-reactive protein increased 16.09 11.12 431 216696 63129 42341079
Bronchial irritation 16.06 11.12 7 217120 46 42404162
Hypopnoea 16.00 11.12 81 217046 7801 42396407
Scar 16.00 11.12 7 217120 6681 42397527
Anger 15.98 11.12 26 217101 12992 42391216
Urinary retention 15.95 11.12 303 216824 41911 42362297
Lower gastrointestinal haemorrhage 15.95 11.12 102 217025 10706 42393502
Immune-mediated myositis 15.92 11.12 49 217078 3744 42400464
Drug reaction with eosinophilia and systemic symptoms 15.90 11.12 302 216825 41773 42362435
Aplastic anaemia 15.90 11.12 24 217103 12360 42391848
Glomerular filtration rate 15.82 11.12 9 217118 111 42404097
Ocular myasthenia 15.78 11.12 17 217110 560 42403648
Atypical fibroxanthoma 15.75 11.12 11 217116 198 42404010
Oliguria 15.72 11.12 91 217036 9222 42394986
Immune effector cell-associated neurotoxicity syndrome 15.69 11.12 15 217112 9446 42394762
Vomiting 15.64 11.12 1267 215860 288456 42115752
Hypoaesthesia 15.56 11.12 263 216864 71200 42333008
Amaurosis fugax 15.56 11.12 19 217108 718 42403490
Seasonal allergy 15.56 11.12 11 217116 8044 42396164
Glycosylated haemoglobin decreased 15.55 11.12 15 217112 432 42403776
Documented hypersensitivity to administered product 15.55 11.12 13 217114 309 42403899
Hip fracture 15.53 11.12 28 217099 13444 42390764
Wrong drug 15.44 11.12 10 217117 158 42404050
Pericardial disease 15.37 11.12 16 217111 506 42403702
Fear 15.32 11.12 20 217107 10945 42393263
Coronary artery disease 15.28 11.12 370 216757 53350 42350858
Cytomegalovirus infection 15.27 11.12 99 217028 32207 42372001
Physical examination abnormal 15.16 11.12 15 217112 446 42403762
Phlebitis infective 15.15 11.12 9 217118 121 42404087
Endoscopy upper gastrointestinal tract abnormal 15.11 11.12 7 217120 54 42404154
Subarachnoid haematoma 15.10 11.12 12 217115 265 42403943
Aspiration 15.09 11.12 44 217083 17842 42386366
Leptotrichia infection 15.09 11.12 8 217119 85 42404123
Euglycaemic diabetic ketoacidosis 15.08 11.12 63 217064 5597 42398611
Gamma-glutamyltransferase increased 15.06 11.12 241 216886 32256 42371952
Hypoglycaemic coma 15.00 11.12 39 217088 2705 42401503
Product administered to patient of inappropriate age 14.99 11.12 3 217124 4758 42399450
Muscle spasms 14.96 11.12 329 216798 85715 42318493
Candida infection 14.93 11.12 58 217069 21552 42382656
Polyomavirus-associated nephropathy 14.89 11.12 5 217122 5610 42398598
Night sweats 14.84 11.12 52 217075 19917 42384291
Tenderness 14.83 11.12 14 217113 8869 42395339
Gastroenteritis viral 14.80 11.12 12 217115 8187 42396021
Cytopenia 14.80 11.12 43 217084 17454 42386754
Puncture site haematoma 14.76 11.12 10 217117 171 42404037
Hepatitis cholestatic 14.68 11.12 93 217034 9731 42394477
Right ventricular dysfunction 14.64 11.12 26 217101 1383 42402825
Body mass index increased 14.63 11.12 24 217103 1197 42403011
Muscle tightness 14.63 11.12 5 217122 5548 42398660
End stage renal disease 14.51 11.12 40 217087 16518 42387690
Plateletcrit decreased 14.50 11.12 6 217121 34 42404174
Immunosuppression 14.49 11.12 13 217114 8440 42395768
Emotional disorder 14.49 11.12 7 217120 6307 42397901
Device pacing issue 14.49 11.12 7 217120 60 42404148
Neoplasm malignant 14.48 11.12 63 217064 22680 42381528
Body temperature increased 14.48 11.12 54 217073 20304 42383904
Blood phosphorus increased 14.47 11.12 26 217101 12499 42391709
Posterior reversible encephalopathy syndrome 14.47 11.12 27 217100 12794 42391414
Eye irritation 14.46 11.12 22 217105 11296 42392912
Serotonin syndrome 14.46 11.12 75 217052 25770 42378438
Joint range of motion decreased 14.44 11.12 11 217116 7742 42396466
Conjunctivitis allergic 14.44 11.12 6 217121 5905 42398303
Splenic cyst 14.41 11.12 9 217118 133 42404075
Pulmonary valve disease 14.41 11.12 14 217113 407 42403801
Post procedural haematoma 14.40 11.12 28 217099 1597 42402611
Osteoma 14.39 11.12 8 217119 94 42404114
Retinal phototoxicity 14.39 11.12 4 217123 4 42404204
Anorectal discomfort 14.38 11.12 34 217093 2221 42401987
Cardio-respiratory arrest 14.38 11.12 211 216916 58425 42345783
Blood glucose decreased 14.30 11.12 32 217095 14187 42390021
IgA nephropathy 14.29 11.12 35 217092 2339 42401869
Reticulocytosis 14.26 11.12 12 217115 288 42403920
Withdrawal syndrome 14.25 11.12 34 217093 14741 42389467
Catatonia 14.19 11.12 7 217120 6232 42397976
Lip oedema 14.18 11.12 42 217085 3142 42401066
Photosensitivity reaction 14.16 11.12 112 217015 12590 42391618
Aortic dissection 14.14 11.12 41 217086 3031 42401177
Angiogram 14.09 11.12 10 217117 185 42404023
Intentional product misuse 14.07 11.12 226 216901 61674 42342534
Glomerular filtration rate increased 14.07 11.12 19 217108 795 42403413
Nephroangiosclerosis 14.04 11.12 10 217117 186 42404022
Polycystic liver disease 14.04 11.12 8 217119 99 42404109
Gastrointestinal adenocarcinoma 14.01 11.12 7 217120 65 42404143
Nodular melanoma 13.99 11.12 10 217117 187 42404021
Cardiac discomfort 13.97 11.12 18 217109 719 42403489
Subcutaneous abscess 13.95 11.12 3 217124 4525 42399683
Product administration interrupted 13.92 11.12 4 217123 4962 42399246
Tricuspid valve calcification 13.92 11.12 4 217123 5 42404203
Tongue disorder 13.91 11.12 5 217122 5378 42398830
Discharge 13.87 11.12 16 217111 569 42403639
Uveitis 13.87 11.12 16 217111 9242 42394966
Haemorrhage subcutaneous 13.84 11.12 37 217090 2609 42401599
Plasma cell myeloma recurrent 13.81 11.12 6 217121 5751 42398457
Craniocerebral injury 13.81 11.12 47 217080 3787 42400421
Facial asymmetry 13.78 11.12 13 217114 364 42403844
Postictal paralysis 13.78 11.12 13 217114 364 42403844
Drop attacks 13.74 11.12 16 217111 575 42403633
Hepatic enzyme increased 13.72 11.12 158 216969 45626 42358582
Infected skin ulcer 13.71 11.12 31 217096 1967 42402241
Erosive duodenitis 13.68 11.12 29 217098 1760 42402448
Creatinine renal clearance decreased 13.64 11.12 45 217082 3568 42400640
Drug level fluctuating 13.63 11.12 17 217110 657 42403551
Total lung capacity abnormal 13.57 11.12 3 217124 4440 42399768
Hepatic cytolysis 13.56 11.12 202 216925 26642 42377566
Oedema 13.56 11.12 354 216773 51647 42352561
Supine hypertension 13.55 11.12 13 217114 372 42403836
Gastrointestinal angiodysplasia 13.55 11.12 17 217110 661 42403547
Sexual dysfunction 13.42 11.12 9 217118 6766 42397442
Brain natriuretic peptide abnormal 13.41 11.12 13 217114 377 42403831
Gait spastic 13.38 11.12 25 217102 1384 42402824
Urosepsis 13.37 11.12 126 217001 14894 42389314
Hypophosphataemia 13.35 11.12 58 217069 20887 42383321
Blood creatine increased 13.32 11.12 61 217066 5639 42398569
Prostatic specific antigen increased 13.31 11.12 43 217084 16882 42387326
Disturbance in attention 13.29 11.12 220 216907 29646 42374562
Reflux nephropathy 13.29 11.12 5 217122 21 42404187
Pleuritic pain 13.23 11.12 10 217117 7067 42397141
Ascites 13.20 11.12 206 216921 56472 42347736
Hepatitis B 13.18 11.12 9 217118 6702 42397506
Anaemia of malignant disease 13.17 11.12 15 217112 526 42403682
Lipids abnormal 13.17 11.12 14 217113 454 42403754
Nervousness 13.17 11.12 31 217096 13501 42390707
Temperature intolerance 13.16 11.12 4 217123 4784 42399424
Procedural haemorrhage 13.16 11.12 38 217089 2803 42401405
Oropharyngeal swelling 13.12 11.12 16 217111 604 42403604
Product preparation error 13.12 11.12 4 217123 4774 42399434
Procalcitonin increased 13.11 11.12 33 217094 2243 42401965
Renal disorder 13.10 11.12 90 217037 28890 42375318
Affective disorder 13.09 11.12 7 217120 5953 42398255
Traumatic haematoma 13.06 11.12 18 217109 768 42403440
Adverse event 13.01 11.12 69 217058 23571 42380637
Lymphadenopathy 13.00 11.12 108 217019 33257 42370951
Perihepatic abscess 12.94 11.12 8 217119 116 42404092
Splenic necrosis 12.88 11.12 8 217119 117 42404091
Mean cell haemoglobin concentration 12.88 11.12 6 217121 47 42404161
Dialysis 12.87 11.12 26 217101 11960 42392248
Eosinophilic granulomatosis with polyangiitis 12.86 11.12 15 217112 8623 42395585
Tuberculosis bladder 12.85 11.12 3 217124 0 42404208
Neonatal deafness 12.85 11.12 3 217124 0 42404208
Multiple sclerosis relapse 12.85 11.12 34 217093 14230 42389978
Subclavian artery occlusion 12.82 11.12 8 217119 118 42404090
Basal ganglia haemorrhage 12.80 11.12 21 217106 1047 42403161
Flagellate dermatitis 12.77 11.12 8 217119 119 42404089
Lymphocyte count decreased 12.75 11.12 86 217041 27723 42376485
Peripheral ischaemia 12.71 11.12 66 217061 6419 42397789
Cardiorenal syndrome 12.71 11.12 19 217108 874 42403334
Hyperkinetic heart syndrome 12.71 11.12 8 217119 120 42404088
Primary hypoparathyroidism 12.67 11.12 6 217121 49 42404159
Cardiac ventricular disorder 12.66 11.12 11 217116 276 42403932
Hepatitis C 12.66 11.12 20 217107 10113 42394095
Brain contusion 12.66 11.12 20 217107 966 42403242
Hypoparathyroidism 12.65 11.12 17 217110 708 42403500
Oesophageal infection 12.63 11.12 12 217115 339 42403869
Glaucoma 12.63 11.12 14 217113 8234 42395974
Aggression 12.62 11.12 154 216973 44009 42360199
Hepatosplenomegaly 12.62 11.12 4 217123 4656 42399552
Ammonia increased 12.61 11.12 4 217123 4655 42399553
Foot deformity 12.61 11.12 5 217122 5063 42399145
Psychiatric decompensation 12.60 11.12 3 217124 4219 42399989
Hiccups 12.56 11.12 27 217100 12144 42392064
Colorectal cancer 12.49 11.12 5 217122 5033 42399175
Lipid metabolism disorder 12.47 11.12 14 217113 483 42403725
Fluid intake reduced 12.45 11.12 47 217080 3985 42400223
C-reactive protein decreased 12.45 11.12 32 217095 2204 42402004
Low cardiac output syndrome 12.44 11.12 16 217111 638 42403570
Renal haematoma 12.44 11.12 16 217111 638 42403570
Diffuse vasculitis 12.40 11.12 7 217120 85 42404123
Device difficult to use 12.35 11.12 4 217123 4592 42399616
Relapsing-remitting multiple sclerosis 12.33 11.12 25 217102 1470 42402738
Liver palpable 12.30 11.12 11 217116 287 42403921
Cardiac hypertrophy 12.27 11.12 22 217105 1179 42403029
Blood calcium increased 12.25 11.12 15 217112 8439 42395769
Pneumonia bacterial 12.25 11.12 40 217087 15652 42388556
Adrenomegaly 12.24 11.12 13 217114 421 42403787
Ventricular asystole 12.24 11.12 11 217116 289 42403919
Intention tremor 12.18 11.12 14 217113 496 42403712
Hiatus hernia 12.15 11.12 80 217047 8480 42395728
Sinus arrest 12.15 11.12 31 217096 2125 42402083
Periarthritis calcarea 12.12 11.12 7 217120 89 42404119
Potentiating drug interaction 12.11 11.12 65 217062 6403 42397805
Pseudohyponatraemia 12.11 11.12 8 217119 131 42404077
Feeling abnormal 12.09 11.12 267 216860 69519 42334689
Vasculitic rash 12.07 11.12 20 217107 1006 42403202
Leg amputation 12.07 11.12 35 217092 2588 42401620
Osteochondrosis 12.04 11.12 24 217103 1394 42402814
Immune system disorder 12.01 11.12 8 217119 6036 42398172
Femoral artery aneurysm 11.99 11.12 9 217118 182 42404026
Conduction disorder 11.97 11.12 34 217093 2484 42401724
Thyroiditis 11.94 11.12 40 217087 3196 42401012
Feeling jittery 11.93 11.12 4 217123 4494 42399714
Hyperglycaemia 11.90 11.12 312 216815 45547 42358661
Weight decreased 11.89 11.12 905 216222 207043 42197165
Hypersensitivity vasculitis 11.89 11.12 40 217087 3204 42401004
Generalised tonic-clonic seizure 11.88 11.12 82 217045 26297 42377911
Gastric haemorrhage 11.88 11.12 93 217034 10422 42393786
Articular calcification 11.85 11.12 7 217120 93 42404115
Basal cell carcinoma 11.85 11.12 172 216955 22561 42381647
FEV1/FVC ratio decreased 11.85 11.12 8 217119 136 42404072
Eye infection gonococcal 11.85 11.12 5 217122 30 42404178
Loss of proprioception 11.81 11.12 13 217114 439 42403769
Periorbital haematoma 11.80 11.12 12 217115 369 42403839
Bladder diverticulum 11.80 11.12 8 217119 137 42404071
Supraventricular extrasystoles 11.80 11.12 46 217081 3960 42400248
Complication associated with device 11.79 11.12 10 217117 6671 42397537
Necrotising myositis 11.79 11.12 21 217106 1120 42403088
Drug withdrawal syndrome neonatal 11.78 11.12 4 217123 4457 42399751
Burning sensation 11.75 11.12 61 217066 20952 42383256
Ill-defined disorder 11.73 11.12 43 217084 16253 42387955
Post-traumatic headache 11.71 11.12 6 217121 59 42404149
Bone pain 11.71 11.12 72 217055 23720 42380488
Cardiomyopathy alcoholic 11.71 11.12 5 217122 31 42404177
Inhibitory drug interaction 11.68 11.12 28 217099 1846 42402362
Cerebrospinal fluid circulation disorder 11.66 11.12 4 217123 12 42404196
Muscle rupture 11.65 11.12 33 217094 2407 42401801
Loss of personal independence in daily activities 11.62 11.12 181 216946 49635 42354573
Parosmia 11.61 11.12 73 217054 7618 42396590
Visual acuity reduced 11.55 11.12 48 217079 17502 42386706
Nocardiosis 11.54 11.12 6 217121 5184 42399024
Sinus tachycardia 11.52 11.12 60 217067 20593 42383615
Road traffic accident 11.49 11.12 54 217073 19039 42385169
Rhinorrhoea 11.47 11.12 105 217022 31689 42372519
Hepatic encephalopathy 11.44 11.12 44 217083 16398 42387810
Blood chloride increased 11.44 11.12 42 217085 3514 42400694
Mucosal haemorrhage 11.43 11.12 27 217100 1763 42402445
Peritonitis bacterial 11.43 11.12 11 217116 6904 42397304
Rash vesicular 11.40 11.12 40 217087 3273 42400935
Overflow diarrhoea 11.38 11.12 6 217121 63 42404145
Intrapericardial thrombosis 11.38 11.12 6 217121 63 42404145
Pancreatitis acute 11.37 11.12 237 216890 33327 42370881
Chronic obstructive pulmonary disease 11.36 11.12 240 216887 62874 42341334
Bilirubin conjugated abnormal 11.35 11.12 7 217120 101 42404107
Cardiomegaly 11.32 11.12 133 216994 16633 42387575
Gait inability 11.29 11.12 69 217058 22764 42381444
Prothrombin time shortened 11.29 11.12 25 217102 1564 42402644
Drug level decreased 11.27 11.12 21 217106 9956 42394252
Paradoxical drug reaction 11.27 11.12 5 217122 4733 42399475
Burning feet syndrome 11.24 11.12 7 217120 103 42404105
Activated partial thromboplastin time abnormal 11.22 11.12 8 217119 149 42404059
Mania 11.22 11.12 23 217104 10524 42393684
Liver function test increased 11.21 11.12 58 217069 19940 42384268
N-terminal prohormone brain natriuretic peptide 11.19 11.12 4 217123 14 42404194
Bladder tamponade 11.19 11.12 15 217112 623 42403585
Poikiloderma 11.18 11.12 11 217116 325 42403883
Arterial stenosis 11.17 11.12 21 217106 1168 42403040
Electrocardiogram ST segment depression 11.16 11.12 35 217092 2702 42401506
Skin burning sensation 11.15 11.12 13 217114 7474 42396734
Acute myeloid leukaemia 11.14 11.12 67 217060 22189 42382019

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 3476.93 10.35 7289 390869 628141 109563000
Bradycardia 2477.77 10.35 2925 395233 152592 110038549
Cardiac failure 1945.90 10.35 2858 395300 184768 110006373
Drug interaction 1624.12 10.35 4704 393454 495479 109695662
Hyperkalaemia 1560.91 10.35 2173 395985 133623 110057518
Atrial fibrillation 1207.32 10.35 2598 395560 227044 109964097
Hypotension 1051.33 10.35 4195 393963 519654 109671487
Melaena 802.55 10.35 1109 397049 67648 110123493
Syncope 797.27 10.35 2047 396111 200489 109990652
Drug ineffective 792.07 10.35 2821 395337 1517719 108673422
Lactic acidosis 785.14 10.35 1288 396870 91523 110099618
Hyponatraemia 769.81 10.35 2114 396044 215539 109975602
Anaemia 705.77 10.35 3852 394306 543234 109647907
Hand deformity 705.25 10.35 17 398141 218489 109972652
Glossodynia 646.26 10.35 38 398120 221966 109969175
Pemphigus 614.77 10.35 40 398118 214530 109976611
Infusion related reaction 599.58 10.35 312 397846 380850 109810291
Synovitis 588.19 10.35 133 398025 273959 109917182
International normalised ratio increased 564.12 10.35 1073 397085 85699 110105442
Maternal exposure during pregnancy 548.27 10.35 123 398035 254760 109936381
Helicobacter infection 539.05 10.35 28 398130 181849 110009292
Arthropathy 535.98 10.35 183 397975 287339 109903802
Completed suicide 533.50 10.35 111 398047 242270 109948871
General physical health deterioration 520.19 10.35 2953 395205 422342 109768799
Duodenal ulcer perforation 512.39 10.35 32 398126 177668 110013473
Off label use 502.59 10.35 3257 394901 1496928 108694213
Systemic lupus erythematosus 502.38 10.35 146 398012 254192 109936949
Cerebral haemorrhage 499.35 10.35 864 397294 64104 110127037
Renal impairment 488.90 10.35 1642 396516 186803 110004338
Swelling 487.80 10.35 333 397825 350708 109840433
Pain 477.33 10.35 1799 396359 953156 109237985
Folliculitis 475.10 10.35 33 398125 167620 110023521
Sinus bradycardia 472.76 10.35 557 397601 28926 110162215
Drug hypersensitivity 467.82 10.35 568 397590 453522 109737619
Irritable bowel syndrome 466.29 10.35 32 398126 164183 110026958
Treatment failure 464.70 10.35 208 397950 277026 109914115
Rhabdomyolysis 462.23 10.35 1206 396952 119195 110071946
Fibromyalgia 455.67 10.35 44 398114 170865 110020276
Sinusitis 453.06 10.35 252 397906 296436 109894705
Cardiac failure chronic 448.78 10.35 383 397775 13428 110177713
Psoriatic arthropathy 445.79 10.35 84 398074 196677 109994464
Therapeutic product effect decreased 444.18 10.35 162 397996 244154 109946987
Arrhythmia 443.16 10.35 853 397305 68722 110122419
Muscle injury 432.54 10.35 17 398141 140790 110050351
Ventricular tachycardia 432.25 10.35 701 397457 49308 110141833
Fall 428.35 10.35 3668 394490 599814 109591327
Product dose omission issue 417.49 10.35 328 397830 321454 109869687
Systemic infection 413.81 10.35 317 397841 9502 110181639
Dyspnoea 413.64 10.35 5922 392236 1100950 109090191
Joint swelling 413.18 10.35 596 397562 442249 109748892
Ischaemic stroke 406.10 10.35 614 397544 40649 110150492
Atrioventricular block 401.57 10.35 393 397765 16484 110174657
Angina pectoris 393.38 10.35 761 397397 61534 110129607
Drug intolerance 386.23 10.35 540 397618 405972 109785169
Haematuria 386.02 10.35 895 397263 82110 110109031
Mitral valve incompetence 384.94 10.35 535 397623 32794 110158347
Haematoma 371.27 10.35 716 397442 57760 110133381
Stomatitis 370.49 10.35 260 397898 269982 109921159
Sleep disorder due to general medical condition, insomnia type 363.00 10.35 3 398155 105640 110085501
Hypoglycaemia 349.55 10.35 1065 397093 115039 110076102
Joint range of motion decreased 348.05 10.35 23 398135 121809 110069332
Shock haemorrhagic 347.54 10.35 459 397699 26788 110164353
C-reactive protein abnormal 346.74 10.35 33 398125 129662 110061479
Atrioventricular block complete 344.76 10.35 393 397765 19689 110171452
Nasopharyngitis 344.45 10.35 555 397603 393806 109797335
Subarachnoid haemorrhage 340.37 10.35 475 397683 29227 110161914
Lip dry 338.49 10.35 4 398154 100079 110091062
Bursitis 337.11 10.35 37 398121 129881 110061260
Exposure during pregnancy 334.43 10.35 94 398064 167330 110023811
Left ventricular dysfunction 329.80 10.35 415 397743 23078 110168063
Renal failure 325.41 10.35 1645 396513 224929 109966212
Orthostatic hypotension 324.28 10.35 729 397429 65520 110125621
Presyncope 323.19 10.35 609 397549 48278 110142863
Dehydration 322.56 10.35 1912 396246 277599 109913542
Hypokalaemia 321.56 10.35 1406 396752 181042 110010099
Blood cholesterol increased 320.15 10.35 132 398026 184653 110006488
Alopecia 312.29 10.35 520 397638 364233 109826908
Rheumatoid factor positive 311.72 10.35 50 398108 131590 110059551
Product use issue 311.26 10.35 399 397759 311296 109879845
Hypersensitivity 311.01 10.35 615 397543 403383 109787758
Ejection fraction decreased 310.63 10.35 541 397617 40339 110150802
Sopor 308.65 10.35 507 397651 36039 110155102
Product prescribing error 307.05 10.35 613 397545 50718 110140423
Injury 306.50 10.35 127 398031 177138 110014003
Discomfort 304.39 10.35 199 397959 214508 109976633
Electrocardiogram QT prolonged 301.75 10.35 971 397187 107989 110083152
Hypertensive crisis 300.76 10.35 404 397754 23968 110167173
Acute myocardial infarction 299.06 10.35 817 397341 82960 110108181
Hepatic enzyme increased 297.05 10.35 434 397724 320458 109870683
Impaired healing 296.02 10.35 170 397988 196547 109994594
Ill-defined disorder 293.62 10.35 99 398059 156754 110034387
Hypomagnesaemia 290.68 10.35 660 397498 59710 110131431
Abdominal discomfort 289.23 10.35 616 397542 393242 109797899
Death 282.46 10.35 1425 396733 697444 109493697
Subdural haematoma 277.72 10.35 483 397675 35971 110155170
Labelled drug-drug interaction medication error 277.02 10.35 428 397730 28874 110162267
Rash 276.83 10.35 1776 396382 819188 109371953
Palpitations 276.02 10.35 1221 396937 157991 110033150
Wound 275.97 10.35 262 397896 234175 109956966
Circulatory collapse 271.16 10.35 525 397633 42468 110148673
Oedema peripheral 270.81 10.35 2068 396090 326592 109864549
Arthralgia 263.11 10.35 1686 396472 777946 109413195
Blister 260.81 10.35 260 397898 227116 109964025
Cardiogenic shock 255.39 10.35 608 397550 56730 110134411
Atrial tachycardia 249.35 10.35 230 397928 8948 110182193
Infection 247.55 10.35 589 397569 361611 109829530
Night sweats 246.56 10.35 87 398071 133896 110057245
Product use in unapproved indication 245.42 10.35 809 397349 446568 109744573
Injection site pain 244.01 10.35 171 397987 177751 110013390
Grip strength decreased 238.59 10.35 12 398146 80162 110110979
Pericarditis 230.80 10.35 269 397889 218845 109972296
Rheumatoid arthritis 227.99 10.35 459 397699 299154 109891987
Bradyarrhythmia 225.01 10.35 167 397991 4767 110186374
Urticaria 223.09 10.35 512 397646 318345 109872796
Electrocardiogram abnormal 223.07 10.35 305 397853 18404 110172737
Rectal haemorrhage 223.01 10.35 939 397219 118894 110072247
Osteoarthritis 222.13 10.35 198 397960 182425 110008716
Musculoskeletal stiffness 219.54 10.35 421 397737 279401 109911740
Mobility decreased 218.78 10.35 322 397836 237100 109954041
Gastrointestinal haemorrhage 217.71 10.35 1173 396985 164345 110026796
Upper gastrointestinal haemorrhage 215.37 10.35 524 397634 49572 110141569
Acute coronary syndrome 214.86 10.35 335 397823 22777 110168364
N-terminal prohormone brain natriuretic peptide increased 213.83 10.35 177 397981 5944 110185197
Cardiospasm 212.92 10.35 162 397996 4805 110186336
Haematemesis 211.50 10.35 577 397581 58531 110132610
Dyspnoea exertional 210.73 10.35 837 397321 103223 110087918
Asthma 210.27 10.35 361 397797 249930 109941211
Cerebral infarction 209.96 10.35 530 397628 51308 110139833
Hypoaesthesia 209.93 10.35 517 397641 313706 109877435
Palmoplantar keratoderma 207.68 10.35 165 397993 5222 110185919
Interstitial lung disease 198.78 10.35 1010 397148 138324 110052817
Type 2 diabetes mellitus 198.29 10.35 207 397951 177025 110014116
Gait inability 197.91 10.35 123 398035 136253 110054888
Electrolyte imbalance 197.69 10.35 422 397736 36606 110154535
Upper respiratory tract infection 196.82 10.35 114 398044 131214 110059927
Lower limb fracture 196.63 10.35 21 398137 75327 110115814
Live birth 195.87 10.35 14 398144 69470 110121671
Haematochezia 193.44 10.35 877 397281 114647 110076494
Anuria 192.61 10.35 328 397830 24013 110167128
Road traffic accident 192.09 10.35 73 398085 107325 110083816
Peripheral venous disease 190.27 10.35 36 398122 84081 110107060
Injection site erythema 189.67 10.35 52 398106 94124 110097017
Pruritus genital 188.06 10.35 169 397989 6353 110184788
Confusional state 187.94 10.35 2542 395616 466138 109725003
Injection site reaction 187.41 10.35 45 398113 89025 110102116
Hemiparesis 185.30 10.35 456 397702 43447 110147694
Disease progression 184.64 10.35 375 397783 243659 109947482
Sleep disorder 183.40 10.35 269 397889 198375 109992766
Blepharospasm 181.97 10.35 3 398155 54848 110136293
Coronary artery stenosis 180.46 10.35 235 397923 13523 110177618
Sciatica 178.77 10.35 55 398103 92344 110098797
Weight increased 172.49 10.35 850 397308 418794 109772347
Metabolic acidosis 171.33 10.35 763 397395 98981 110092160
Carotid artery occlusion 170.68 10.35 191 397967 9374 110181767
Vertigo 167.32 10.35 688 397470 86182 110104959
Dyspnoea at rest 166.96 10.35 177 397981 8169 110182972
Sleep terror 166.81 10.35 159 397999 6451 110184690
Eosinophilia 166.46 10.35 523 397635 57413 110133728
International normalised ratio fluctuation 165.98 10.35 129 398029 3951 110187190
Jaundice 164.96 10.35 529 397629 58707 110132434
Product monitoring error 164.01 10.35 181 397977 8746 110182395
Pregnancy 160.88 10.35 5 398153 51062 110140079
Product quality issue 160.78 10.35 40 398118 77259 110113882
Lower respiratory tract infection 158.43 10.35 405 397753 242701 109948440
Cardiac failure acute 157.94 10.35 299 397859 23779 110167362
Myelosuppression 157.61 10.35 71 398087 94269 110096872
White blood cell count decreased 157.45 10.35 372 397786 229018 109962123
Wound infection 157.45 10.35 75 398083 96390 110094751
Autoimmune disorder 154.72 10.35 25 398133 65458 110125683
Headache 154.22 10.35 2243 395915 880134 109311007
Loss of consciousness 154.20 10.35 1222 396936 195084 109996057
Blood creatinine increased 153.39 10.35 1156 397002 181733 110009408
Mental status changes 153.35 10.35 42 398116 76080 110115061
Cholestasis 153.05 10.35 546 397612 63972 110127169
Atrial flutter 150.22 10.35 294 397864 23968 110167173
Tachyarrhythmia 149.19 10.35 166 397992 8095 110183046
Obesity 148.82 10.35 114 398044 113237 110077904
Inflammation 148.68 10.35 294 397864 192944 109998197
Bone erosion 148.06 10.35 4 398154 46367 110144774
Immunisation 147.99 10.35 109 398049 3074 110188067
Gastrointestinal disorder 147.17 10.35 417 397741 241535 109949606
Tension headache 144.80 10.35 176 397982 9442 110181699
Knee arthroplasty 144.36 10.35 29 398129 64919 110126222
Glomerular filtration rate decreased 144.32 10.35 321 397837 28635 110162506
Hypocalcaemia 143.12 10.35 539 397619 64827 110126314
Hospitalisation 141.52 10.35 183 397975 142310 110048831
Chronic kidney disease 138.95 10.35 594 397564 75697 110115444
Tachycardia 138.03 10.35 1334 396824 225311 109965830
Hemiplegia 137.34 10.35 273 397885 22509 110168632
Therapy non-responder 136.59 10.35 222 397936 157085 110034056
Epistaxis 136.44 10.35 870 397288 129502 110061639
Adjustment disorder with depressed mood 135.76 10.35 5 398153 43878 110147263
Contraindicated product administered 135.26 10.35 450 397708 247817 109943324
Torsade de pointes 135.26 10.35 270 397888 22330 110168811
Lip swelling 133.45 10.35 444 397714 50223 110140918
Hypercholesterolaemia 130.30 10.35 83 398075 90754 110100387
Hallucination 129.39 10.35 713 397445 100719 110090422
Wrong patient received product 129.02 10.35 139 398019 6535 110184606
Neuropathy peripheral 128.46 10.35 284 397874 178993 110012148
Hip arthroplasty 128.13 10.35 23 398135 55790 110135351
Injection site pruritus 127.04 10.35 17 398141 51241 110139900
Ventricular arrhythmia 125.66 10.35 168 397990 9919 110181222
Congestive cardiomyopathy 125.13 10.35 201 397957 14018 110177123
Ventricular hypokinesia 125.00 10.35 177 397981 11037 110180104
Depression 124.52 10.35 653 397505 316682 109874459
Diastolic dysfunction 124.05 10.35 186 397972 12218 110178923
Myocardial infarction 123.63 10.35 1144 397014 190939 110000202
Coeliac disease 120.87 10.35 9 398149 43178 110147963
Adverse event 120.66 10.35 128 398030 108681 110082460
Nail disorder 120.45 10.35 30 398128 57905 110133236
Drug ineffective for unapproved indication 119.70 10.35 116 398042 102722 110088419
Tricuspid valve incompetence 119.37 10.35 265 397893 23608 110167533
Back injury 119.21 10.35 15 398143 47384 110143757
X-ray abnormal 119.12 10.35 4 398154 38113 110153028
Cerebral haematoma 117.82 10.35 159 397999 9473 110181668
Ear infection 116.66 10.35 40 398118 62692 110128449
Sleep disorder due to a general medical condition 116.38 10.35 23 398135 52089 110139052
Onychomadesis 115.95 10.35 14 398144 45649 110145492
Orthopnoea 115.59 10.35 169 397989 10852 110180289
Pemphigoid 115.03 10.35 233 397925 19474 110171667
Cardioactive drug level increased 114.72 10.35 102 398056 3780 110187361
Neck pain 113.37 10.35 167 397991 122963 110068178
Dizziness 112.62 10.35 3300 394858 694893 109496248
Rales 111.95 10.35 264 397894 24475 110166666
Anosmia 110.71 10.35 177 397981 12295 110178846
Bundle branch block left 109.09 10.35 179 397979 12709 110178432
Pallor 108.56 10.35 447 397711 56020 110135121
Disorientation 108.36 10.35 523 397635 70148 110120993
No adverse event 107.94 10.35 66 398092 73773 110117368
Onychomycosis 107.92 10.35 8 398150 38523 110152618
Dry mouth 107.13 10.35 365 397793 199583 109991558
Urinary retention 107.07 10.35 516 397642 69167 110121974
Hypovolaemic shock 106.89 10.35 190 397968 14393 110176748
Blood creatine phosphokinase increased 105.78 10.35 532 397626 72545 110118596
Liver injury 104.73 10.35 242 397916 150171 110040970
Bloody discharge 103.84 10.35 83 398075 2650 110188491
Tinnitus 102.36 10.35 461 397697 60079 110131062
Transient ischaemic attack 102.10 10.35 479 397679 63503 110127638
Aortic valve stenosis 101.84 10.35 120 398038 6230 110184911
Inappropriate antidiuretic hormone secretion 101.33 10.35 310 397848 33541 110157600
Therapeutic product effect incomplete 100.95 10.35 438 397720 223367 109967774
Blood pressure decreased 99.59 10.35 733 397425 114358 110076783
Exercise tolerance decreased 98.65 10.35 165 397993 11902 110179239
Hyperthyroidism 98.11 10.35 279 397879 28982 110162159
Urogenital haemorrhage 97.68 10.35 54 398104 910 110190231
Wheezing 97.44 10.35 530 397628 254700 109936441
Sinus node dysfunction 96.73 10.35 140 398018 8907 110182234
Illness 96.44 10.35 92 398066 82079 110109062
Hallucination, visual 96.36 10.35 338 397820 39267 110151874
C-reactive protein 95.43 10.35 3 398155 30328 110160813
Gastrooesophageal reflux disease 95.43 10.35 330 397828 179646 110011495
Brain natriuretic peptide increased 95.30 10.35 156 398002 11053 110180088
Dysarthria 95.30 10.35 573 397585 83548 110107593
Injection site swelling 94.92 10.35 52 398106 61738 110129403
Drug abuse 93.59 10.35 326 397832 177085 110014056
Haemarthrosis 92.74 10.35 123 398035 7206 110183935
Lupus vulgaris 92.21 10.35 8 398150 33875 110157266
Foot deformity 91.74 10.35 30 398128 48450 110142691
Blood pressure systolic decreased 90.76 10.35 169 397989 13272 110177869
Ventricular extrasystoles 90.12 10.35 230 397928 22411 110168730
Ischaemic cardiomyopathy 90.11 10.35 127 398031 7884 110183257
Myocardial ischaemia 90.03 10.35 255 397903 26429 110164712
Contusion 89.40 10.35 484 397674 232877 109958264
Venous pressure jugular increased 88.12 10.35 57 398101 1295 110189846
Unevaluable event 87.89 10.35 52 398106 59175 110131966
Bronchial secretion retention 87.38 10.35 99 398059 4925 110186216
Haemorrhage intracranial 87.37 10.35 266 397892 28703 110162438
Facial pain 86.74 10.35 179 397979 15160 110175981
Neurologic neglect syndrome 86.74 10.35 135 398023 9163 110181978
Joint stiffness 86.52 10.35 69 398089 67174 110123967
Laryngitis 86.18 10.35 23 398135 42388 110148753
Agranulocytosis 86.16 10.35 445 397713 61315 110129826
Toxic skin eruption 86.15 10.35 256 397902 27259 110163882
Nasal congestion 85.96 10.35 138 398020 98144 110092997
Faeces discoloured 85.44 10.35 293 397865 33655 110157486
Right atrial hypertrophy 84.89 10.35 44 398114 647 110190494
Migraine 84.89 10.35 324 397834 171328 110019813
Vascular purpura 84.50 10.35 85 398073 3686 110187455
Carotid artery thrombosis 84.48 10.35 136 398022 9502 110181639
Paraesthesia 83.55 10.35 617 397541 275904 109915237
Cerebrovascular accident 83.39 10.35 1009 397149 180275 110010866
Ventricular enlargement 82.96 10.35 44 398114 680 110190461
Therapy interrupted 82.43 10.35 38 398120 49784 110141357
Peripheral swelling 82.04 10.35 995 397163 403039 109788102
Haemorrhagic stroke 81.64 10.35 164 397994 13625 110177516
Accidental exposure to product 81.41 10.35 39 398119 49969 110141172
Injection site bruising 80.42 10.35 42 398116 51221 110139920
Prescribed overdose 80.41 10.35 119 398039 87462 110103679
Embolic stroke 80.25 10.35 126 398032 8617 110182524
Pain in extremity 80.14 10.35 1252 396906 485866 109705275
Duodenal ulcer haemorrhage 79.64 10.35 120 398038 7917 110183224
Exostosis 79.28 10.35 33 398125 45923 110145218
Hepatocellular injury 79.24 10.35 377 397781 50265 110140876
Muscle spasms 77.79 10.35 634 397524 277523 109913618
Fatigue 77.37 10.35 3585 394573 1212373 108978768
Finger deformity 77.36 10.35 13 398145 33079 110158062
Erysipelas 77.31 10.35 156 398002 13002 110178139
Asthenia 76.86 10.35 3121 395037 685878 109505263
Microcytic anaemia 76.60 10.35 103 398055 6115 110185026
Intentional product use issue 76.41 10.35 550 397608 247356 109943785
Full blood count decreased 76.40 10.35 12 398146 32087 110159054
Respiratory tract haemorrhage 76.17 10.35 61 398097 1953 110189188
Aphasia 76.09 10.35 416 397742 58581 110132560
Peripheral arterial occlusive disease 76.01 10.35 127 398031 9153 110181988
Febrile neutropenia 75.06 10.35 753 397405 316014 109875127
Disability 74.96 10.35 10 398148 30213 110160928
Disturbance in attention 73.90 10.35 428 397730 61567 110129574
Liver function test abnormal 73.90 10.35 463 397695 68487 110122654
Therapy cessation 73 10.35 35 398123 44822 110146319
Insomnia 72.82 10.35 889 397269 359701 109831440
Arterial occlusive disease 72.16 10.35 166 397992 15142 110175999
Shock 71.91 10.35 382 397776 53206 110137935
Haematoma muscle 71.83 10.35 81 398077 4009 110187132
Abnormal loss of weight 71.81 10.35 131 398027 10126 110181015
Angioedema 71.27 10.35 602 397556 97898 110093243
Vital capacity decreased 70.45 10.35 59 398099 2014 110189127
Incorrect route of product administration 70.30 10.35 76 398082 63985 110127156
Vasculitis 69.76 10.35 285 397873 35588 110155553
Ear pain 69.26 10.35 54 398104 53172 110137969
Memory impairment 69.22 10.35 420 397738 196524 109994617
Thrombocytopenia 68.98 10.35 1694 396464 347191 109843950
Product label confusion 68.74 10.35 3 398155 22674 110168467
Inferior vena cava dilatation 68.57 10.35 43 398115 924 110190217
Atrioventricular block second degree 68.40 10.35 113 398045 8068 110183073
Lichen planopilaris 68.36 10.35 25 398133 145 110190996
Product administration error 67.93 10.35 290 397868 36927 110154214
Vascular stent thrombosis 67.34 10.35 79 398079 4082 110187059
Acute pulmonary oedema 66.97 10.35 172 397986 16824 110174317
Gamma-glutamyltransferase increased 66.52 10.35 413 397745 60896 110130245
Toxicity to various agents 66.20 10.35 1275 396883 479280 109711861
Osteoporosis 65.80 10.35 134 398024 87018 110104123
Atrioventricular block first degree 65.67 10.35 153 398005 14072 110177069
Pain of skin 65.24 10.35 189 397969 19840 110171301
Injection site rash 65.20 10.35 5 398153 23414 110167727
Left atrial enlargement 64.55 10.35 52 398106 1679 110189462
Hypothermia 64.44 10.35 225 397933 26077 110165064
Diplopia 64.19 10.35 310 397848 41584 110149557
Musculoskeletal pain 63.44 10.35 392 397766 182631 110008510
Therapeutic response decreased 63.41 10.35 160 397998 96339 110094802
Left ventricular failure 63.34 10.35 132 398026 11257 110179884
Atrial thrombosis 62.95 10.35 78 398080 4268 110186873
Left ventricular hypertrophy 62.85 10.35 144 398014 13100 110178041
Gravitational oedema 62.41 10.35 53 398105 1845 110189296
Immunodeficiency 62.15 10.35 31 398127 38807 110152334
Abdominal wall haematoma 62.04 10.35 89 398069 5616 110185525
Pleural effusion 61.94 10.35 941 397217 176768 110014373
Lyme disease 61.78 10.35 77 398081 4239 110186902
Skin haemorrhage 61.36 10.35 213 397945 24614 110166527
Adjustment disorder 61.07 10.35 126 398032 10669 110180472
Drug dependence 61.07 10.35 54 398104 49966 110141175
Device issue 60.87 10.35 24 398134 34511 110156630
Oliguria 60.72 10.35 176 397982 18481 110172660
Drug resistance 60.63 10.35 68 398090 56306 110134835
Eye pruritus 60.29 10.35 256 397902 32519 110158622
Lupus-like syndrome 60.26 10.35 36 398122 40756 110150385
Abortion spontaneous 60.14 10.35 24 398134 34258 110156883
Rash maculo-papular 59.86 10.35 465 397693 73757 110117384
Drug reaction with eosinophilia and systemic symptoms 59.00 10.35 501 397657 81594 110109547
Degenerative mitral valve disease 58.92 10.35 27 398131 298 110190843
Cardiac murmur 58.89 10.35 209 397949 24419 110166722
Pulmonary function test abnormal 58.83 10.35 81 398077 4919 110186222
Chronic sinusitis 58.31 10.35 10 398148 25074 110166067
Walking aid user 58.28 10.35 10 398148 25065 110166076
Flushing 58.28 10.35 188 397970 104548 110086593
Oesophageal perforation 58.01 10.35 48 398110 1611 110189530
Hyponatraemic syndrome 57.93 10.35 36 398122 761 110190380
Tachypnoea 57.85 10.35 288 397870 39107 110152034
Product dose omission in error 57.79 10.35 8 398150 23504 110167637
Therapeutic drug monitoring analysis not performed 57.59 10.35 51 398107 1880 110189261
Multimorbidity 57.40 10.35 46 398112 1474 110189667
Motor dysfunction 57.40 10.35 206 397952 24200 110166941
Polyneuropathy 57.32 10.35 248 397910 31764 110159377
Aortic valve incompetence 57.29 10.35 124 398034 10857 110180284
Systolic dysfunction 57.26 10.35 75 398083 4340 110186801
Taste disorder 57.00 10.35 92 398066 65295 110125846
Pancreatitis acute 56.85 10.35 392 397766 59882 110131259
Duodenal ulcer 56.82 10.35 177 397981 19337 110171804
Potentiating drug interaction 56.81 10.35 128 398030 11515 110179626
Sinoatrial block 56.75 10.35 45 398113 1420 110189721
Liver disorder 56.70 10.35 291 397867 141952 110049189
Right ventricular hypertrophy 56.52 10.35 48 398110 1671 110189470
Rash papular 56.47 10.35 223 397935 27416 110163725
Duodenitis 56.40 10.35 111 398047 9085 110182056
Lower gastrointestinal haemorrhage 55.99 10.35 170 397988 18316 110172825
Condition aggravated 55.97 10.35 2122 396036 732714 109458427
Gangrene 55.95 10.35 157 398001 16184 110174957
Medication error 55.88 10.35 603 397555 104763 110086378
Hyperglycaemia 55.83 10.35 509 397649 84581 110106560
Dyspepsia 55.81 10.35 430 397728 190535 110000606
Blood pressure increased 55.78 10.35 1270 396888 257103 109934038
Blood loss anaemia 55.76 10.35 167 397991 17858 110173283
Chest pain 55.71 10.35 1761 396397 374614 109816527
Intraventricular haemorrhage 55.67 10.35 83 398075 5424 110185717
Neutrophil count decreased 55.54 10.35 235 397923 120706 110070435
Dermatitis atopic 55.53 10.35 12 398146 25529 110165612
Angina unstable 55.40 10.35 157 398001 16275 110174866
Normal newborn 54.89 10.35 7 398151 21889 110169252
Personality disorder 54.87 10.35 134 398024 12703 110178438
Atrial enlargement 54.84 10.35 40 398118 1111 110190030
Subcutaneous haematoma 54.81 10.35 61 398097 2975 110188166
Pericardial haemorrhage 54.71 10.35 80 398078 5137 110186004
Respiratory arrest 53.72 10.35 79 398079 58220 110132921
Polyuria 53.61 10.35 163 397995 17575 110173566
Minimum inhibitory concentration 53.50 10.35 21 398137 152 110190989
Occult blood 53.33 10.35 48 398110 1808 110189333
Head injury 53.25 10.35 300 397858 42717 110148424
Adverse reaction 53.10 10.35 20 398138 29574 110161567
Sensory loss 52.95 10.35 184 397974 21273 110169868
Blindness 52.82 10.35 265 397893 36094 110155047
Lung disorder 52.81 10.35 405 397753 179642 110011499
Nodule 52.28 10.35 26 398132 32605 110158536
Cardiomyopathy 52.03 10.35 249 397909 33276 110157865
Myoglobin blood increased 51.98 10.35 70 398088 4162 110186979
Stress 51.98 10.35 199 397959 105149 110085992
Cardiac aneurysm 51.86 10.35 46 398112 1699 110189442
Reversible airways obstruction 51.77 10.35 54 398104 2445 110188696
Back disorder 51.70 10.35 7 398151 20915 110170226
Infusion site reaction 51.50 10.35 3 398155 17679 110173462
Nightmare 51.44 10.35 276 397882 38587 110152554
BRASH syndrome 51.03 10.35 65 398093 3658 110187483
Food allergy 50.93 10.35 6 398152 19942 110171199
Fungal infection 50.68 10.35 65 398093 50741 110140400
Malignant mediastinal neoplasm 50.55 10.35 41 398117 1337 110189804
Intestinal haemorrhage 50.44 10.35 93 398065 7248 110183893
Hepatojugular reflux 50.41 10.35 32 398126 703 110190438
Therapy partial responder 50.28 10.35 36 398122 37025 110154116
Dermatitis bullous 50.12 10.35 158 398000 17371 110173770
Gastritis erosive 49.95 10.35 124 398034 11876 110179265
Hepatitis cholestatic 49.92 10.35 158 398000 17408 110173733
Device difficult to use 49.68 10.35 5 398153 18800 110172341
Oropharyngeal pain 49.37 10.35 285 397873 134991 110056150
Extrasystoles 49.33 10.35 99 398059 8219 110182922
Bronchitis 49.04 10.35 347 397811 156685 110034456
ECG signs of myocardial ischaemia 49.01 10.35 26 398132 402 110190739
Antimicrobial susceptibility test resistant 48.67 10.35 26 398132 408 110190733
Inflammatory marker increased 48.55 10.35 138 398020 14331 110176810
Cardiovascular disorder 48.42 10.35 186 397972 22574 110168567
Cerebral ischaemia 48.21 10.35 123 398035 11981 110179160
Troponin T increased 48.04 10.35 68 398090 4238 110186903
Left ventricular enlargement 47.81 10.35 33 398125 838 110190303
Platelet count decreased 47.68 10.35 565 397593 229878 109961263
Cardiovascular insufficiency 47.61 10.35 59 398099 3229 110187912
Electrocardiogram Q wave abnormal 47.59 10.35 31 398127 713 110190428
Subdural haemorrhage 47.50 10.35 85 398073 6473 110184668
Femoral hernia incarcerated 47.30 10.35 41 398117 1468 110189673
Emotional distress 47.25 10.35 55 398103 44792 110146349
Liver function test increased 47.16 10.35 162 397996 88386 110102755
Procedural pain 46.38 10.35 36 398122 35529 110155612
Cerebellar haemorrhage 46.25 10.35 58 398100 3213 110187928
Muscle twitching 46.22 10.35 222 397936 29713 110161428
Strangury 45.97 10.35 21 398137 230 110190911
Burns second degree 45.81 10.35 92 398066 7641 110183500
Pancytopenia 45.75 10.35 1032 397126 208581 109982560
Drug level increased 45.39 10.35 311 397847 47408 110143733
Thalamus haemorrhage 45.35 10.35 45 398113 1919 110189222
Coma scale abnormal 45.33 10.35 105 398053 9621 110181520
Porphyria acute 44.74 10.35 7 398151 18773 110172368
Injection site urticaria 44.40 10.35 5 398153 17210 110173931
Diverticulum intestinal haemorrhagic 44.21 10.35 69 398089 4694 110186447
Renin increased 44.09 10.35 23 398135 343 110190798
Hypersensitivity vasculitis 44.08 10.35 85 398073 6852 110184289
Bronchial wall thickening 43.97 10.35 56 398102 3151 110187990
Sedation 43.90 10.35 118 398040 69565 110121576
Bacterial infection 43.78 10.35 61 398097 45975 110145166
Altered state of consciousness 43.72 10.35 356 397802 57270 110133871
Peripheral ischaemia 43.66 10.35 112 398046 10946 110180195
Lymphatic fistula 43.62 10.35 39 398119 1456 110189685
Multiple sclerosis relapse 43.50 10.35 71 398087 50169 110140972
IVth nerve paralysis 43.48 10.35 28 398130 631 110190510
Paresis 43.34 10.35 69 398089 4775 110186366
Adverse drug reaction 43.18 10.35 214 397944 105345 110085796
Tendon rupture 43.14 10.35 130 398028 13948 110177193
Catarrh 43.14 10.35 87 398071 7248 110183893
Bundle branch block right 42.98 10.35 119 398039 12172 110178969
Soft tissue mass 42.78 10.35 39 398119 1494 110189647
Urosepsis 42.76 10.35 221 397937 30454 110160687
Vasoplegia syndrome 42.64 10.35 73 398085 5366 110185775
Graft versus host disease 42.63 10.35 8 398150 18798 110172343
Chronic coronary syndrome 42.60 10.35 21 398137 276 110190865
Hyperuricaemia 42.49 10.35 132 398026 14399 110176742
Extremity necrosis 42.36 10.35 60 398098 3742 110187399
Hepatic cytolysis 42.25 10.35 341 397817 54712 110136429
Arterial haemorrhage 42.15 10.35 60 398098 3759 110187382
Female genital tract fistula 42.10 10.35 5 398153 16514 110174627
Craniocerebral injury 41.81 10.35 76 398082 5858 110185283
Gastroenteritis viral 41.50 10.35 31 398127 31195 110159946
Drug monitoring procedure not performed 41.41 10.35 36 398122 1294 110189847
Retroperitoneal haematoma 41.28 10.35 77 398081 6054 110185087
Dry eye 41.09 10.35 87 398071 55706 110135435
Seizure 41.03 10.35 555 397603 220630 109970511
Tubulointerstitial nephritis 40.99 10.35 335 397823 53949 110137192
Pancreatic steatosis 40.70 10.35 41 398117 1781 110189360
Aortic arteriosclerosis 40.34 10.35 108 398050 10830 110180311
Sinus rhythm 40.32 10.35 32 398126 1011 110190130
Lupus vasculitis 40.14 10.35 26 398132 592 110190549
Immune thrombocytopenia 40.07 10.35 174 397984 22320 110168821
Retinal artery occlusion 40.07 10.35 62 398096 4187 110186954
Carotid artery stenosis 39.92 10.35 97 398061 9166 110181975
Viral infection 39.86 10.35 82 398076 53057 110138084
Muscle haemorrhage 39.83 10.35 81 398077 6788 110184353
Haemothorax 39.70 10.35 82 398076 6949 110184192
Coordination abnormal 39.60 10.35 188 397970 25040 110166101
Mitral valve thickening 39.56 10.35 28 398130 741 110190400
International normalised ratio abnormal 39.31 10.35 77 398081 6280 110184861
Ventricular fibrillation 39.14 10.35 269 397889 41044 110150097
Nephrolithiasis 38.85 10.35 116 398042 66096 110125045
Heart rate decreased 38.64 10.35 462 397696 82294 110108847
Affect lability 38.59 10.35 151 398007 18486 110172655
Product dispensing error 38.47 10.35 138 398020 16207 110174934
Normocytic anaemia 38.38 10.35 77 398081 6390 110184751
Coronary artery disease 38.34 10.35 411 397747 71279 110119862
Drug use disorder 38.27 10.35 9 398149 18065 110173076
Cardiac tamponade 38.09 10.35 108 398050 11199 110179942
Heart sounds abnormal 38.07 10.35 36 398122 1446 110189695
Leriche syndrome 37.96 10.35 16 398142 142 110190999
Acute cutaneous lupus erythematosus 37.94 10.35 22 398136 408 110190733
Drug dispensed to wrong patient 37.90 10.35 27 398131 722 110190419
Hypoglycaemic coma 37.90 10.35 70 398088 5463 110185678
Small intestinal obstruction 37.87 10.35 36 398122 32177 110158964
Pulmonary oedema 37.80 10.35 540 397618 100119 110091022
Suspected suicide 37.76 10.35 5 398153 15194 110175947
Purpura 37.75 10.35 181 397977 24207 110166934
Drug tolerance 37.71 10.35 7 398151 16578 110174563
Ketoacidosis 37.61 10.35 100 398058 9987 110181154
Pulmonary vascular disorder 37.47 10.35 31 398127 1040 110190101
Blood glucose abnormal 37.46 10.35 117 398041 12799 110178342
Therapeutic response shortened 37.25 10.35 31 398127 29552 110161589
Surgery 37.01 10.35 57 398101 41226 110149915
Respiratory symptom 36.93 10.35 5 398153 14940 110176201
Post transplant lymphoproliferative disorder 36.79 10.35 6 398152 15607 110175534
Electrocardiogram PR prolongation 36.71 10.35 39 398119 1804 110189337
Macular degeneration 36.64 10.35 16 398142 21643 110169498
Herpes zoster 36.58 10.35 234 397924 108145 110082996
Acne 36.52 10.35 40 398118 33480 110157661
Pharyngitis streptococcal 36.50 10.35 3 398155 13274 110177867
Multiple-drug resistance 36.36 10.35 3 398155 13232 110177909
Product complaint 36.18 10.35 4 398154 13968 110177173
Multiple sclerosis 36.14 10.35 24 398134 25674 110165467
Blood potassium increased 36.08 10.35 224 397934 33025 110158116
Sinus arrest 36.01 10.35 59 398099 4183 110186958
Device leakage 36.01 10.35 7 398151 16041 110175100
Pneumonia 35.94 10.35 2694 395464 874020 109317121
Cerebral ventricular rupture 35.91 10.35 22 398136 453 110190688
Adrenal insufficiency 35.69 10.35 61 398097 42329 110148812
Optic ischaemic neuropathy 35.64 10.35 58 398100 4089 110187052
Basal cell carcinoma 35.61 10.35 282 397876 44988 110146153
Malaise 35.59 10.35 2844 395314 668975 109522166
Sudden death 35.58 10.35 178 397980 24217 110166924
Monoparesis 35.55 10.35 61 398097 4492 110186649
Drug dose omission by device 35.53 10.35 5 398153 14511 110176630
Myalgia 35.41 10.35 1050 397108 221331 109969810
Anaemia macrocytic 35.31 10.35 80 398078 7223 110183918
Hepatic cirrhosis 35.16 10.35 125 398033 67501 110123640
Pathogen resistance 35.12 10.35 10 398148 17662 110173479
Tongue oedema 35.09 10.35 86 398072 8170 110182971
Dermatitis exfoliative 34.98 10.35 105 398053 11242 110179899
Thrombosis 34.96 10.35 238 397920 108424 110082717
Colitis microscopic 34.93 10.35 117 398041 13277 110177864
Myopathy 34.91 10.35 180 397978 24780 110166361
Hypochromic anaemia 34.90 10.35 50 398108 3151 110187990
Blood urea increased 34.66 10.35 326 397832 54631 110136510
Nocturia 34.64 10.35 137 398021 16853 110174288
Gastric ulcer 34.63 10.35 254 397904 39573 110151568
Colitis erosive 34.53 10.35 18 398140 268 110190873
Hypokinesia 34.52 10.35 163 397995 21663 110169478
Blood thyroid stimulating hormone increased 34.37 10.35 110 398048 12191 110178950
Periorbital haematoma 34.31 10.35 29 398129 1003 110190138
Injection site haemorrhage 34.26 10.35 41 398117 32987 110158154
Diabetic metabolic decompensation 34.25 10.35 55 398103 3834 110187307
Spontaneous haemorrhage 34.23 10.35 31 398127 1177 110189964
Red blood cell sedimentation rate increased 34.22 10.35 155 398003 78147 110112994
Basal ganglia haemorrhage 34.20 10.35 38 398120 1850 110189291
Joint injury 34.18 10.35 57 398101 39937 110151204
Hepatitis acute 34.07 10.35 146 398012 18620 110172521
Polycythaemia 34.03 10.35 50 398108 3225 110187916
Nausea 34.02 10.35 3913 394245 1231777 108959364
Carotid arteriosclerosis 33.70 10.35 48 398110 3009 110188132
Brain stem infarction 33.68 10.35 40 398118 2094 110189047
Cardiac septal hypertrophy 33.65 10.35 20 398138 389 110190752
Infective exacerbation of chronic obstructive airways disease 33.58 10.35 49 398109 3141 110188000
Faecaloma 33.51 10.35 124 398034 14784 110176357
Stress cardiomyopathy 33.49 10.35 129 398029 15677 110175464
Superinfection 33.47 10.35 68 398090 5695 110185446
Exposure via skin contact 33.45 10.35 4 398154 13143 110177998
Dyspnoea paroxysmal nocturnal 33.22 10.35 43 398115 2459 110188682
Irritability 33.20 10.35 77 398081 47732 110143409
Eye irritation 33.16 10.35 43 398115 33409 110157732
Oral herpes 33.14 10.35 49 398109 36031 110155110
Lipids abnormal 33.08 10.35 24 398134 661 110190480
Cold sweat 33.02 10.35 162 397996 21869 110169272
Hypochloraemia 33.01 10.35 52 398106 3566 110187575
Red blood cell sedimentation rate abnormal 33.00 10.35 24 398134 24485 110166656
Abdominal distension 32.96 10.35 438 397720 174665 110016476
Subacute cutaneous lupus erythematosus 32.73 10.35 62 398096 4932 110186209
Hypoxia 32.71 10.35 303 397855 129212 110061929
Urine output decreased 32.58 10.35 150 398008 19726 110171415
Accidental overdose 32.46 10.35 307 397851 51527 110139614
Benign prostatic hyperplasia 32.44 10.35 141 398017 18093 110173048
Temperature regulation disorder 32.40 10.35 4 398154 12822 110178319
Back pain 32.39 10.35 1053 397105 369943 109821198
Supraventricular extrasystoles 32.12 10.35 82 398076 7991 110183150
Anhedonia 32.05 10.35 8 398150 15420 110175721
Aortic dissection 32.03 10.35 61 398097 4872 110186269
Hypopnoea 32.01 10.35 102 398056 11278 110179863
Diabetes mellitus inadequate control 31.94 10.35 200 397958 29575 110161566
Petechiae 31.82 10.35 167 397991 23150 110167991
Brain stem haemorrhage 31.79 10.35 36 398122 1790 110189351
Sputum culture positive 31.55 10.35 53 398105 3836 110187305
Renal phospholipidosis 31.54 10.35 19 398139 379 110190762
Acquired haemophilia 31.53 10.35 43 398115 2588 110188553
Temperature intolerance 31.48 10.35 6 398152 13944 110177197
Peripheral artery stenosis 31.22 10.35 31 398127 1323 110189818
Cardiac dysfunction 31.02 10.35 69 398089 6154 110184987
Spinal cord haemorrhage 30.96 10.35 22 398136 586 110190555
Acute generalised exanthematous pustulosis 30.84 10.35 157 398001 21507 110169634
Weight fluctuation 30.72 10.35 21 398137 22124 110169017
Complication associated with device 30.67 10.35 17 398141 20056 110171085
Gastric haemorrhage 30.59 10.35 126 398032 15789 110175352
Erectile dysfunction 30.39 10.35 140 398018 18416 110172725
Orthostatic intolerance 30.33 10.35 38 398120 2103 110189038
Cytomegalovirus viraemia 30.25 10.35 13 398145 17751 110173390
Embolic cerebral infarction 30.23 10.35 32 398126 1474 110189667
Hypocoagulable state 30.22 10.35 42 398116 2573 110188568
Anxiety 30.22 10.35 979 397179 344099 109847042
Frequent bowel movements 30.20 10.35 143 398015 71247 110119894
Fluid retention 30.12 10.35 207 397951 94100 110097041
Tenderness 30.05 10.35 37 398121 29400 110161741
Disease recurrence 29.86 10.35 115 398043 60669 110130472
Vascular stent stenosis 29.83 10.35 32 398126 1497 110189644
Psoriasis 29.81 10.35 341 397817 139652 110051489
Loss of personal independence in daily activities 29.81 10.35 371 397787 149649 110041492
Toxic epidermal necrolysis 29.77 10.35 324 397834 56403 110134738
Coma 29.48 10.35 592 397566 117277 110073864
Intestinal transit time abnormal 29.44 10.35 12 398146 97 110191044
Electrocardiogram ST segment elevation 29.41 10.35 86 398072 9074 110182067
Diverticulum intestinal 29.36 10.35 101 398057 11618 110179523
Swollen tongue 29.07 10.35 339 397819 60023 110131118
Cardiac amyloidosis 29.03 10.35 43 398115 2794 110188347
Rhinovirus infection 29.00 10.35 4 398154 11785 110179356
Emotional disorder 28.86 10.35 11 398147 16149 110174992
Waist circumference increased 28.82 10.35 34 398124 1767 110189374
BK virus infection 28.81 10.35 6 398152 13100 110178041
Prerenal failure 28.78 10.35 55 398103 4404 110186737
Neoplasm progression 28.75 10.35 127 398031 64468 110126673
Vascular pseudoaneurysm 28.69 10.35 53 398105 4137 110187004
Myocarditis 28.65 10.35 196 397962 29859 110161282
Radiculopathy 28.65 10.35 17 398141 19319 110171822
Foetal death 28.53 10.35 11 398147 16034 110175107
Bone density decreased 28.52 10.35 11 398147 16031 110175110
Bradyphrenia 28.45 10.35 100 398058 11628 110179513
Epstein-Barr virus infection 28.44 10.35 16 398142 18722 110172419
Heart rate irregular 28.34 10.35 216 397942 34058 110157083
Erosive duodenitis 28.30 10.35 38 398120 2253 110188888
Urinary hesitation 28.29 10.35 56 398102 4602 110186539
Intracranial haematoma 28.26 10.35 26 398132 1008 110190133
Candida infection 28.24 10.35 84 398074 47925 110143216
Eosinophil count increased 28.17 10.35 150 398008 20908 110170233
Seroma 28.14 10.35 46 398112 3255 110187886
Spontaneous haematoma 28.09 10.35 35 398123 1926 110189215
Immune-mediated myositis 27.97 10.35 66 398092 6120 110185021
Psychotic disorder 27.94 10.35 92 398066 50845 110140296
Respiratory depression 27.92 10.35 45 398113 31956 110159185
Throat irritation 27.83 10.35 99 398059 53453 110137688
Gallbladder disorder 27.79 10.35 21 398137 21008 110170133
Rhinitis allergic 27.64 10.35 15 398143 17907 110173234
Fracture 27.53 10.35 168 397990 24620 110166521
Skin pressure mark 27.41 10.35 11 398147 85 110191056
Traumatic intracranial haemorrhage 27.24 10.35 30 398128 1446 110189695
Cardiomegaly 27.20 10.35 189 397969 28941 110162200
Vertebrobasilar insufficiency 27.16 10.35 17 398141 364 110190777
Spleen ischaemia 27.06 10.35 10 398148 60 110191081
Seronegative arthritis 27.05 10.35 7 398151 13170 110177971
Cardiac arrest 26.86 10.35 912 397246 195841 109995300
Peripheral artery occlusion 26.85 10.35 42 398116 2863 110188278
Language disorder 26.85 10.35 49 398109 3789 110187352
Wound infection pseudomonas 26.79 10.35 38 398120 2373 110188768
Appendicitis 26.79 10.35 38 398120 28426 110162715
Bleeding time prolonged 26.73 10.35 28 398130 1274 110189867
Jugular vein distension 26.68 10.35 31 398127 1585 110189556
Intentional dose omission 26.60 10.35 20 398138 20060 110171081
Inappropriate schedule of product administration 26.57 10.35 545 397613 203092 109988049
Brain contusion 26.50 10.35 31 398127 1597 110189544
Tachycardia paroxysmal 26.37 10.35 17 398141 384 110190757
Hyperhidrosis 26.29 10.35 871 397287 186427 110004714
Faeces pale 26.24 10.35 45 398113 3312 110187829
Glycosylated haemoglobin increased 26.18 10.35 160 397998 23459 110167682
Transplant rejection 26.02 10.35 30 398128 24537 110166604
Blood lactic acid 25.98 10.35 18 398140 460 110190681
Ischaemic nephropathy 25.96 10.35 11 398147 99 110191042
Thirst 25.96 10.35 150 398008 21557 110169584
Abdominal pain upper 25.88 10.35 1011 397147 348100 109843041
Drug withdrawal syndrome 25.85 10.35 62 398096 37992 110153149
Helicobacter test positive 25.84 10.35 28 398130 1325 110189816
Cytokine release syndrome 25.71 10.35 148 398010 70158 110120983
Haemorrhagic diathesis 25.57 10.35 72 398086 7436 110183705
Basilar artery occlusion 25.55 10.35 15 398143 285 110190856
Peripheral embolism 25.51 10.35 34 398124 2001 110189140
Cholestatic liver injury 25.38 10.35 71 398087 7305 110183836
Crying 25.34 10.35 33 398125 25595 110165546
Laboratory test abnormal 25.30 10.35 78 398080 44001 110147140
Therapeutic response delayed 25.22 10.35 28 398130 1362 110189779
Insurance issue 25.18 10.35 4 398154 10608 110180533
Product administration interrupted 25.18 10.35 5 398153 11287 110179854
Concomitant disease progression 25.14 10.35 46 398112 3564 110187577
Myositis 25.12 10.35 195 397963 30921 110160220
Blood test abnormal 25.05 10.35 40 398118 28514 110162627
Ventricle rupture 25.04 10.35 11 398147 109 110191032
Electrocardiogram T wave inversion 25.03 10.35 60 398098 5620 110185521
Lip oedema 25.02 10.35 72 398086 7528 110183613
Stenosis 25.00 10.35 44 398114 3307 110187834
Peripheral artery bypass 24.95 10.35 11 398147 110 110191031
Premature delivery 24.95 10.35 45 398113 30587 110160554
Hip fracture 24.90 10.35 56 398102 35095 110156046
Platelet distribution width increased 24.87 10.35 12 398146 150 110190991
Sedation complication 24.76 10.35 21 398137 19834 110171307
Poisoning deliberate 24.68 10.35 171 397987 26160 110164981
Hypoparathyroidism 24.68 10.35 29 398129 1501 110189640
Ventricular hyperkinesia 24.61 10.35 15 398143 306 110190835
Drop attacks 24.50 10.35 25 398133 1103 110190038
Feeling hot 24.38 10.35 210 397948 90896 110100245
Deprescribing error 24.35 10.35 9 398149 54 110191087
Tooth disorder 24.35 10.35 43 398115 29466 110161675
Epileptic encephalopathy 24.33 10.35 20 398138 665 110190476
Nodal rhythm 24.32 10.35 44 398114 3379 110187762
Pleuritic pain 24.19 10.35 14 398144 16126 110175015
Sudden hearing loss 24.09 10.35 35 398123 2234 110188907
Hypertensive heart disease 24.09 10.35 52 398106 4544 110186597
Ejection fraction abnormal 23.98 10.35 44 398114 3416 110187725
Sight disability 23.95 10.35 13 398145 211 110190930
Steroid dependence 23.90 10.35 76 398082 8393 110182748
Pulmonary thrombosis 23.84 10.35 10 398148 13853 110177288
Supraventricular tachycardia 23.72 10.35 160 397998 24262 110166879
Hypertension 23.71 10.35 1550 396608 508534 109682607
Chills 23.71 10.35 514 397644 190066 110001075
Vitamin B12 decreased 23.68 10.35 56 398102 5201 110185940
Nodal arrhythmia 23.65 10.35 34 398124 2150 110188991
Procalcitonin abnormal 23.64 10.35 16 398142 393 110190748
Iron deficiency 23.63 10.35 130 398028 18346 110172795
Cerebellar haematoma 23.55 10.35 19 398139 615 110190526
Sinobronchitis 23.53 10.35 17 398141 465 110190676
Nodular melanoma 23.52 10.35 14 398144 273 110190868
Tachycardia induced cardiomyopathy 23.52 10.35 13 398145 219 110190922
Vaginal discharge 23.51 10.35 18 398140 17890 110173251
Blood glucose fluctuation 23.51 10.35 71 398087 7627 110183514
Endocarditis 23.49 10.35 103 398055 13268 110177873
Obstruction 23.48 10.35 59 398099 5693 110185448
Bone disorder 23.41 10.35 25 398133 21167 110169974
Prurigo 23.36 10.35 27 398131 1373 110189768
Cytomegalovirus infection reactivation 23.35 10.35 19 398139 18314 110172827
Cerebrospinal fluid circulation disorder 23.15 10.35 5 398153 0 110191141
Pericardial effusion 23.12 10.35 311 397847 56906 110134235
Mucormycosis 23.09 10.35 5 398153 10623 110180518
Helicobacter gastritis 23.05 10.35 37 398121 2579 110188562
Febrile infection 22.94 10.35 50 398108 4398 110186743
Ocular hyperaemia 22.92 10.35 69 398089 39217 110151924
Ecchymosis 22.85 10.35 123 398035 17215 110173926
IgA nephropathy 22.82 10.35 41 398117 3132 110188009
Post procedural haematoma 22.80 10.35 37 398121 2602 110188539
Blood creatine increased 22.77 10.35 92 398066 11429 110179712
Amaurosis fugax 22.71 10.35 35 398123 2355 110188786
Anticoagulation drug level above therapeutic 22.70 10.35 51 398107 4579 110186562
Hemiataxia 22.69 10.35 8 398150 41 110191100
Acute graft versus host disease 22.62 10.35 9 398149 12872 110178269
Neoplasm malignant 22.57 10.35 64 398094 37079 110154062
Hypernatraemia 22.49 10.35 125 398033 17708 110173433
Bicytopenia 22.43 10.35 64 398094 6660 110184481
Respiratory acidosis 22.41 10.35 104 398054 13722 110177419
Dyslipidaemia 22.24 10.35 115 398043 15850 110175291
Fractional exhaled nitric oxide increased 22.16 10.35 20 398138 756 110190385
Scar 22.12 10.35 17 398141 16864 110174277
Psychomotor retardation 22.06 10.35 70 398088 7722 110183419
Wrong product administered 22.04 10.35 88 398070 10872 110180269
Unintentional medical device removal 22.01 10.35 3 398155 8920 110182221
Adrenal cyst 22.00 10.35 13 398145 250 110190891
Anorectal discomfort 21.99 10.35 47 398111 4079 110187062
Chest wall haematoma 21.95 10.35 17 398141 518 110190623
Influenza 21.93 10.35 453 397705 168648 110022493
Infective spondylitis 21.86 10.35 17 398141 521 110190620
Feeling jittery 21.74 10.35 13 398145 14709 110176432
Percutaneous coronary intervention 21.73 10.35 16 398142 451 110190690
Androgenetic alopecia 21.73 10.35 13 398145 256 110190885
Thermohypoaesthesia 21.69 10.35 10 398148 112 110191029
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.65 10.35 8 398150 48 110191093
Polymerase chain reaction 21.61 10.35 10 398148 113 110191028
Haemorrhagic transformation stroke 21.53 10.35 39 398119 2998 110188143
Transaminases increased 21.43 10.35 334 397824 63056 110128085
Coagulation time prolonged 21.37 10.35 38 398120 2879 110188262
Left ventricular dilatation 21.37 10.35 26 398132 1396 110189745
Eosinophilic granulomatosis with polyangiitis 21.33 10.35 6 398152 10680 110180461
Sneezing 21.32 10.35 192 397966 31792 110159349
Serum procollagen type I N-terminal propeptide increased 21.25 10.35 7 398151 28 110191113
Xyphoid retraction 21.21 10.35 11 398147 162 110190979
Dermatitis exfoliative generalised 21.20 10.35 87 398071 10885 110180256
Extradural haematoma 21.07 10.35 41 398117 3328 110187813
Epilepsy 20.98 10.35 245 397913 99964 110091177
Pneumonia viral 20.94 10.35 7 398151 11150 110179991
Dystonia 20.94 10.35 38 398120 25767 110165374
Cushingoid 20.87 10.35 8 398150 11704 110179437
Face oedema 20.84 10.35 198 397960 33271 110157870
Obstructive pancreatitis 20.82 10.35 24 398134 1217 110189924
Hypogammaglobulinaemia 20.74 10.35 25 398133 20051 110171090
Haemorrhage 20.73 10.35 517 397641 106175 110084966
Pulmonary valve disease 20.65 10.35 14 398144 345 110190796
Hemianopia 20.55 10.35 37 398121 2831 110188310
High density lipoprotein decreased 20.54 10.35 56 398102 5677 110185464
Skull fracture 20.53 10.35 31 398127 2049 110189092
Gastric ischaemia 20.49 10.35 8 398150 57 110191084
Muscle tightness 20.47 10.35 14 398144 14748 110176393
Needle fatigue 20.46 10.35 24 398134 1240 110189901
General physical condition abnormal 20.42 10.35 67 398091 7523 110183618
Spinal operation 20.39 10.35 7 398151 10965 110180176
Breath sounds abnormal 20.39 10.35 159 397999 25245 110165896
Benign gastrointestinal neoplasm 20.38 10.35 10 398148 130 110191011
Atelectasis 20.35 10.35 66 398092 36646 110154495
Hepatic cyst 20.31 10.35 68 398090 7715 110183426
Iron deficiency anaemia 20.30 10.35 188 397970 31371 110159770
Chest X-ray abnormal 20.27 10.35 72 398086 8415 110182726
Hepatic vein dilatation 20.25 10.35 12 398146 232 110190909
Overlap syndrome 20.22 10.35 4 398154 9055 110182086
Product preparation error 20.12 10.35 7 398151 10872 110180269
Ventricular internal diameter abnormal 20.12 10.35 12 398146 235 110190906
Femoral neck fracture 19.98 10.35 94 398064 12473 110178668
Pruritus 19.98 10.35 1812 396346 579748 109611393
Infusion site pain 19.86 10.35 20 398138 17399 110173742
Graft versus host disease in skin 19.84 10.35 3 398155 8251 110182890
Eye infection 19.83 10.35 14 398144 14504 110176637
Injection site warmth 19.83 10.35 20 398138 17385 110173756
Guillain-Barre syndrome 19.82 10.35 84 398074 10660 110180481
Proctitis 19.80 10.35 19 398139 16908 110174233
Histamine level increased 19.79 10.35 10 398148 139 110191002
Haemorrhage subcutaneous 19.74 10.35 54 398104 5485 110185656
Platelet distribution width decreased 19.68 10.35 7 398151 37 110191104
Craniofacial fracture 19.62 10.35 20 398138 881 110190260
Ocular icterus 19.60 10.35 57 398101 5996 110185145
N-terminal prohormone brain natriuretic peptide abnormal 19.55 10.35 13 398145 310 110190831
Paranasal sinus haematoma 19.52 10.35 7 398151 38 110191103
Foot fracture 19.52 10.35 39 398119 25507 110165634
Atypical fibroxanthoma 19.46 10.35 11 398147 194 110190947
Cognitive disorder 19.44 10.35 432 397726 87079 110104062
Melanoderma 19.42 10.35 15 398143 455 110190686
Eczema 19.40 10.35 367 397791 71926 110119215
Posterior reversible encephalopathy syndrome 19.38 10.35 60 398098 33801 110157340
Hepatotoxicity 19.35 10.35 141 398017 63259 110127882
Weight decreased 19.32 10.35 1437 396721 466620 109724521
Cardioversion 19.30 10.35 32 398126 2291 110188850
Caesarean section 19.30 10.35 13 398145 13804 110177337
Dysphagia 19.23 10.35 705 397453 152895 110038246
Glomerular filtration rate increased 19.21 10.35 29 398129 1916 110189225
Mucosal haemorrhage 19.19 10.35 37 398121 2983 110188158
Device breakage 19.17 10.35 13 398145 13756 110177385
Bifascicular block 19.16 10.35 14 398144 390 110190751
Cystitis haemorrhagic 19.15 10.35 10 398148 12199 110178942
Bladder tamponade 19.14 10.35 18 398140 718 110190423
Hepatorenal failure 19.05 10.35 24 398134 1336 110189805
Anaphylactic reaction 19.01 10.35 293 397865 114007 110077134
Thiopurine methyltransferase decreased 18.98 10.35 13 398145 326 110190815
Lipid metabolism disorder 18.96 10.35 17 398141 637 110190504
Fear 18.96 10.35 34 398124 23159 110167982
Bronchiectasis 18.95 10.35 208 397950 36285 110154856
Gynaecomastia 18.93 10.35 76 398082 9414 110181727
Drug therapeutic incompatibility 18.89 10.35 10 398148 154 110190987
Aspergillus infection 18.82 10.35 40 398118 25576 110165565
Oedema 18.78 10.35 594 397564 209382 109981759
Arterial stenosis 18.71 10.35 26 398132 1593 110189548
Premature labour 18.59 10.35 5 398153 9167 110181974
Lipase increased 18.54 10.35 123 398035 18549 110172592
Spinal fusion surgery 18.54 10.35 5 398153 9151 110181990
Eating disorder 18.45 10.35 181 397977 30677 110160464
Hyperbilirubinaemia 18.38 10.35 180 397978 30491 110160650
Nephrosclerosis 18.38 10.35 29 398129 1992 110189149
Limb discomfort 18.37 10.35 80 398078 40774 110150367
Anal haemorrhage 18.37 10.35 49 398109 4903 110186238
Left atrial dilatation 18.34 10.35 40 398118 3520 110187621
Product blister packaging issue 18.33 10.35 13 398145 345 110190796
Traumatic haematoma 18.33 10.35 32 398126 2389 110188752
Allergic sinusitis 18.23 10.35 27 398131 1754 110189387
Hypercapnic coma 18.21 10.35 15 398143 500 110190641
Fluid intake reduced 18.20 10.35 61 398097 6925 110184216
Ulnar nerve injury 18.12 10.35 12 398146 284 110190857
Retrograde amnesia 18.11 10.35 18 398140 769 110190372
Arrhythmia supraventricular 18.10 10.35 32 398126 2414 110188727
Gait spastic 18.08 10.35 25 398133 1524 110189617
Eructation 18.04 10.35 99 398059 13958 110177183
Respiratory disorder 18.02 10.35 167 397991 71215 110119926
Rash scarlatiniform 18.01 10.35 13 398145 355 110190786
Angiocardiogram 18.01 10.35 12 398146 287 110190854
Haemophagocytic lymphohistiocytosis 18.01 10.35 56 398102 31503 110159638
Myopathy toxic 17.95 10.35 23 398135 1302 110189839
Transplant dysfunction 17.93 10.35 4 398154 8324 110182817
Seasonal allergy 17.90 10.35 27 398131 19695 110171446
Spinal disorder 17.82 10.35 10 398148 11718 110179423
Euglycaemic diabetic ketoacidosis 17.80 10.35 86 398072 11537 110179604
Tracheal pain 17.79 10.35 7 398151 51 110191090
Supine hypertension 17.78 10.35 14 398144 437 110190704
Product substitution issue 17.78 10.35 143 398015 22918 110168223
Plasma cell myeloma 17.78 10.35 143 398015 62793 110128348
Lethargy 17.76 10.35 452 397706 93124 110098017
Therapeutic response unexpected 17.71 10.35 37 398121 23806 110167335
Physical examination abnormal 17.69 10.35 15 398143 521 110190620
Ammonia increased 17.68 10.35 4 398154 8246 110182895
Ulcer haemorrhage 17.64 10.35 34 398124 22537 110168604
Amaurosis 17.59 10.35 25 398133 1564 110189577
Demyelination 17.55 10.35 6 398152 9423 110181718
Defect conduction intraventricular 17.54 10.35 17 398141 704 110190437
Body temperature increased 17.52 10.35 120 398038 54593 110136548
Pericardial disease 17.50 10.35 17 398141 706 110190435
Cytopenia 17.50 10.35 53 398105 30063 110161078
Infarction 17.43 10.35 50 398108 5219 110185922
Immunosuppression 17.43 10.35 23 398135 17736 110173405
Vascular encephalopathy 17.42 10.35 18 398140 806 110190335
Cellulitis 17.42 10.35 334 397824 125682 110065459
Subarachnoid haematoma 17.34 10.35 12 398146 306 110190835
Increased appetite 17.30 10.35 17 398141 14960 110176181
Echocardiogram abnormal 17.28 10.35 33 398125 2641 110188500
Mood swings 17.28 10.35 35 398123 22777 110168364
Peripartum cardiomyopathy 17.22 10.35 10 398148 186 110190955
Hyperkaliuria 17.22 10.35 10 398148 186 110190955
Skin dystrophy 17.13 10.35 7 398151 57 110191084
Renal artery stenosis 17.12 10.35 40 398118 3686 110187455
Enthesopathy 17.09 10.35 12 398146 12466 110178675
Breast cancer female 17.06 10.35 12 398146 12456 110178685
Product administered to patient of inappropriate age 17.02 10.35 4 398154 8032 110183109
Alcohol poisoning 17.01 10.35 71 398087 8949 110182192
Synovial cyst 17.01 10.35 10 398148 11420 110179721
Gout 17.00 10.35 204 397954 36362 110154779
Immune reconstitution inflammatory syndrome 16.98 10.35 20 398138 16206 110174935
Procollagen type I C-terminal propeptide increased 16.98 10.35 6 398152 31 110191110
Skin burning sensation 16.95 10.35 33 398125 21792 110169349
Hypertensive angiopathy 16.87 10.35 8 398150 96 110191045
Renal tubular acidosis 16.83 10.35 46 398112 4669 110186472
Pneumonia fungal 16.75 10.35 17 398141 14737 110176404
Endoscopy upper gastrointestinal tract abnormal 16.72 10.35 7 398151 61 110191080
Febrile bone marrow aplasia 16.71 10.35 114 398044 17351 110173790
Ear pruritus 16.65 10.35 3 398155 7257 110183884
Hepatitis fulminant 16.64 10.35 68 398090 8492 110182649
Renal injury 16.62 10.35 26 398132 18687 110172454
Brain stem ischaemia 16.62 10.35 12 398146 328 110190813
Cardiac fibrillation 16.61 10.35 20 398138 1062 110190079
Prothrombin time shortened 16.60 10.35 39 398119 3607 110187534
Hypersomnia 16.58 10.35 49 398109 28012 110163129
Inflammatory bowel disease 16.56 10.35 3 398155 7231 110183910
Respiratory tract congestion 16.54 10.35 177 397981 30680 110160461
Hepatocellular carcinoma 16.52 10.35 75 398083 9805 110181336
Postrenal failure 16.51 10.35 18 398140 858 110190283
Facial paresis 16.48 10.35 54 398104 6059 110185082
Device failure 16.48 10.35 3 398155 7204 110183937
Sinus congestion 16.46 10.35 175 397983 30284 110160857
Drug effective for unapproved indication 16.46 10.35 16 398142 14151 110176990
Ocular myasthenia 16.46 10.35 17 398141 761 110190380
Oesophageal infection 16.46 10.35 17 398141 761 110190380
Incorrect dose administered 16.46 10.35 268 397890 103373 110087768
Injection site extravasation 16.45 10.35 8 398150 10161 110180980
Haemoptysis 16.41 10.35 354 397804 71000 110120141
Parosmia 16.37 10.35 92 398066 13088 110178053
Low cardiac output syndrome 16.26 10.35 20 398138 1086 110190055
Rotator cuff syndrome 16.22 10.35 22 398136 16772 110174369
Muscular weakness 16.22 10.35 1070 397088 247398 109943743
Pharyngitis 16.19 10.35 42 398116 25056 110166085
Bronchial irritation 16.15 10.35 7 398151 67 110191074
Musculoskeletal disorder 16.14 10.35 36 398122 22628 110168513
Glomerular filtration rate abnormal 16.14 10.35 30 398128 2353 110188788
Aortic stenosis 16.11 10.35 91 398067 12968 110178173
Cerebral artery embolism 16.10 10.35 28 398130 2084 110189057
Cerebral artery occlusion 16.09 10.35 27 398131 1953 110189188
Body height decreased 16.06 10.35 9 398149 10554 110180587
Gastrointestinal angiodysplasia 16.01 10.35 21 398137 1217 110189924
Peripheral coldness 15.98 10.35 118 398040 18422 110172719
Brain natriuretic peptide abnormal 15.98 10.35 18 398140 890 110190251
Osteoma 15.97 10.35 8 398150 109 110191032
Oral candidiasis 15.95 10.35 95 398063 44665 110146476
Vascular stent occlusion 15.95 10.35 11 398147 279 110190862
Middle insomnia 15.92 10.35 31 398127 20471 110170670
Leg amputation 15.91 10.35 42 398116 4176 110186965
Post procedural haemorrhage 15.90 10.35 103 398055 15409 110175732
Clostridium difficile infection 15.87 10.35 116 398042 52013 110139128
Dermo-hypodermitis 15.87 10.35 23 398135 1465 110189676
Necrotising myositis 15.87 10.35 27 398131 1975 110189166
Hypochromasia 15.86 10.35 16 398142 696 110190445
Fear of eating 15.86 10.35 14 398144 514 110190627
Glaucoma 15.85 10.35 36 398122 22481 110168660
Gingival bleeding 15.83 10.35 124 398034 19715 110171426
Nocturnal dyspnoea 15.81 10.35 26 398132 1849 110189292
Wrong patient 15.74 10.35 23 398135 1476 110189665
Discoloured vomit 15.72 10.35 27 398131 1990 110189151
Hepatitis toxic 15.69 10.35 52 398106 5869 110185272
Neuralgia 15.68 10.35 106 398052 48372 110142769
Mania 15.67 10.35 32 398126 20764 110170377
Cyanosis 15.66 10.35 170 397988 29571 110161570
Subclavian artery occlusion 15.66 10.35 9 398149 164 110190977
Polyomavirus-associated nephropathy 15.65 10.35 5 398153 8196 110182945
Mononeuropathy 15.62 10.35 12 398146 361 110190780
Eye haematoma 15.61 10.35 11 398147 289 110190852
Putamen haemorrhage 15.47 10.35 14 398144 531 110190610
Bladder sphincter atony 15.47 10.35 10 398148 227 110190914
Troponin I increased 15.46 10.35 49 398109 5403 110185738
Pustule 15.43 10.35 37 398121 3467 110187674
Post procedural complication 15.42 10.35 47 398111 26611 110164530
Electrocardiogram ST segment depression 15.41 10.35 49 398109 5412 110185729
Catatonia 15.30 10.35 11 398147 11289 110179852
Tricuspid valve calcification 15.30 10.35 4 398154 5 110191136
Pyrexia 15.28 10.35 2926 395232 895339 109295802
Pre-eclampsia 15.26 10.35 6 398152 8644 110182497
Cytomegalovirus infection 15.24 10.35 124 398034 54320 110136821
Polycystic liver disease 15.24 10.35 9 398149 173 110190968
Incorrect dose administered by device 15.23 10.35 3 398155 6811 110184330
Anaemia megaloblastic 15.23 10.35 17 398141 832 110190309
Plateletcrit decreased 15.22 10.35 6 398152 44 110191097
Gonorrhoea 15.16 10.35 10 398148 235 110190906
Cardiac discomfort 15.12 10.35 22 398136 1406 110189735
Coronavirus test positive 15.12 10.35 21 398137 1286 110189855
Renal infarct 15.11 10.35 36 398122 3359 110187782
Cardiac hypertrophy 15.09 10.35 26 398132 1921 110189220
Bacteraemia 15.09 10.35 90 398068 42300 110148841
Wrong dose 15.08 10.35 31 398127 2618 110188523
Nerve injury 15.07 10.35 10 398148 10703 110180438
Subcapsular renal haematoma 15.07 10.35 18 398140 948 110190193
Pain in jaw 15.05 10.35 115 398043 51062 110140079
Blood calcium decreased 15.04 10.35 72 398086 35773 110155368
Injection site discolouration 14.97 10.35 7 398151 9096 110182045
Retroperitoneal haemorrhage 14.96 10.35 52 398106 6013 110185128
Tooth abscess 14.95 10.35 28 398130 18761 110172380
Device use error 14.93 10.35 7 398151 9082 110182059
Walking disability 14.88 10.35 30 398128 2498 110188643
Congestive hepatopathy 14.88 10.35 47 398111 5173 110185968
Decreased immune responsiveness 14.87 10.35 8 398150 9598 110181543
Urinary bladder haemorrhage 14.87 10.35 32 398126 2790 110188351
Nerve compression 14.87 10.35 11 398147 11126 110180015
Ventricular dysfunction 14.86 10.35 60 398098 7451 110183690
Nicotine dependence 14.82 10.35 21 398137 1310 110189831
Anticoagulation drug level increased 14.79 10.35 18 398140 967 110190174
Base excess decreased 14.78 10.35 12 398146 392 110190749
Adenomatous polyposis coli 14.67 10.35 11 398147 319 110190822
Mean cell haemoglobin concentration 14.67 10.35 6 398152 49 110191092
Glomerular filtration rate 14.66 10.35 9 398149 186 110190955
Cerebellar syndrome 14.66 10.35 53 398105 6249 110184892
Vasospasm 14.65 10.35 23 398135 1573 110189568
Laryngeal discomfort 14.60 10.35 16 398142 767 110190374
Red cell distribution width increased 14.59 10.35 111 398047 17491 110173650
Gastric ulcer perforation 14.50 10.35 28 398130 2260 110188881
Transitional cell carcinoma 14.49 10.35 34 398124 3141 110188000
Erythrodermic psoriasis 14.49 10.35 26 398132 1984 110189157
Ischaemia 14.49 10.35 68 398090 9015 110182126
Venous pressure jugular decreased 14.47 10.35 7 398151 88 110191053
Shock symptom 14.46 10.35 13 398145 489 110190652
Laryngeal haematoma 14.45 10.35 9 398149 191 110190950
Antipsychotic drug level above therapeutic 14.42 10.35 29 398129 2411 110188730
Hypovolaemia 14.39 10.35 130 398028 21544 110169597
Acidosis 14.38 10.35 134 398024 22397 110168744
Pulmonary hypertension 14.36 10.35 279 397879 54941 110136200
Primary hypoparathyroidism 14.36 10.35 6 398152 52 110191089
Blood pressure inadequately controlled 14.33 10.35 60 398098 7573 110183568
Documented hypersensitivity to administered product 14.30 10.35 19 398139 1115 110190026
Ultrasound uterus abnormal 14.28 10.35 5 398153 25 110191116
Troponin increased 14.25 10.35 167 397991 29599 110161542
Restlessness 14.21 10.35 283 397875 55976 110135165
Urinary incontinence 14.21 10.35 250 397908 48337 110142804
Hyperkinetic heart syndrome 14.21 10.35 8 398150 140 110191001
Respiratory tract infection 14.20 10.35 348 397810 71269 110119872
Gastritis 14.20 10.35 272 397886 53427 110137714
Long QT syndrome 14.19 10.35 57 398101 7061 110184080
First trimester pregnancy 14.16 10.35 4 398154 8 110191133
Right atrial enlargement 14.15 10.35 13 398145 503 110190638
Puncture site haematoma 14.15 10.35 10 398148 264 110190877
Ventricular asystole 14.15 10.35 12 398146 417 110190724
Thrombin time prolonged 14.09 10.35 11 398147 339 110190802
Somnolence 14.09 10.35 1249 396909 296200 109894941
Liver palpable 14.07 10.35 11 398147 340 110190801
Bladder diverticulum 14.06 10.35 8 398150 143 110190998
Osmotic demyelination syndrome 14.00 10.35 26 398132 2037 110189104
Periarthritis calcarea 14.00 10.35 7 398151 95 110191046
Plasma cell myeloma recurrent 13.97 10.35 4 398154 7038 110184103
Cutaneous vasculitis 13.96 10.35 86 398072 12643 110178498
Pulmonary fibrosis 13.93 10.35 271 397887 101771 110089370
Agitation 13.93 10.35 518 397640 112533 110078608
Postictal paralysis 13.92 10.35 14 398144 607 110190534
Procalcitonin increased 13.92 10.35 39 398119 4017 110187124
Hormone-dependent prostate cancer 13.89 10.35 9 398149 205 110190936
Spleen scan abnormal 13.89 10.35 3 398155 0 110191141
Trepopnoea 13.89 10.35 3 398155 0 110191141
Calcification metastatic 13.86 10.35 8 398150 147 110190994
Acute graft versus host disease in skin 13.84 10.35 11 398147 10729 110180412
Abnormal precordial movement 13.84 10.35 4 398154 9 110191132
Arthritis 13.82 10.35 479 397679 167107 110024034
Procedural haemorrhage 13.79 10.35 47 398111 5380 110185761
Dysaesthesia 13.79 10.35 55 398103 6792 110184349
Trifascicular block 13.78 10.35 9 398149 208 110190933
Withdrawal syndrome 13.78 10.35 62 398096 31318 110159823
Activated partial thromboplastin time shortened 13.78 10.35 18 398140 1039 110190102
Red cell distribution width abnormal 13.76 10.35 10 398148 276 110190865
Blood sodium decreased 13.76 10.35 204 397954 38115 110153026
Peripheral sensory neuropathy 13.72 10.35 105 398053 16575 110174566
Sarcoidosis 13.72 10.35 15 398143 12564 110178577
Tetany 13.71 10.35 36 398122 3568 110187573
Ovarian cyst 13.71 10.35 18 398140 13912 110177229
Thrombolysis 13.67 10.35 10 398148 279 110190862
Hypoparathyroidism secondary 13.67 10.35 10 398148 279 110190862
Sudden cardiac death 13.62 10.35 48 398110 5589 110185552
Supraventricular tachyarrhythmia 13.58 10.35 8 398150 153 110190988
Aortic aneurysm 13.56 10.35 71 398087 9833 110181308
Vasculitic rash 13.55 10.35 27 398131 2230 110188911
Staphylococcal scalded skin syndrome 13.54 10.35 13 398145 532 110190609
Tongue disorder 13.54 10.35 19 398139 14279 110176862
Eye infection gonococcal 13.53 10.35 5 398153 30 110191111
Hypertrophic cardiomyopathy 13.50 10.35 33 398125 3130 110188011
Status epilepticus 13.49 10.35 63 398095 31508 110159633
Splenic cyst 13.49 10.35 10 398148 285 110190856
Traumatic haemorrhage 13.48 10.35 24 398134 1820 110189321
Prostatitis 13.47 10.35 43 398115 4758 110186383
Ultrasound abdomen abnormal 13.46 10.35 10 398148 286 110190855
Blood aldosterone increased 13.41 10.35 9 398149 218 110190923
Change of bowel habit 13.40 10.35 31 398127 2838 110188303
Intestinal ischaemia 13.40 10.35 102 398056 16077 110175064
Blood calcium increased 13.39 10.35 28 398130 18012 110173129
Heavy menstrual bleeding 13.37 10.35 24 398134 16341 110174800
Pelvic pain 13.37 10.35 23 398135 15919 110175222
Thermal burn 13.36 10.35 6 398152 7982 110183159
Intrapericardial thrombosis 13.36 10.35 6 398152 63 110191078
Saliva altered 13.28 10.35 13 398145 545 110190596
Gastrointestinal vascular malformation haemorrhagic 13.23 10.35 17 398141 965 110190176
Transferrin saturation decreased 13.23 10.35 20 398138 1323 110189818
Renal haematoma 13.22 10.35 17 398141 966 110190175
Gastric pH increased 13.19 10.35 6 398152 65 110191076
Dilatation atrial 13.18 10.35 37 398121 3815 110187326
Metastases to nervous system 13.16 10.35 10 398148 296 110190845
Psychogenic visual disorder 13.13 10.35 5 398153 33 110191108
Nephrotic syndrome 13.07 10.35 90 398068 13741 110177400
Injection site induration 13.06 10.35 13 398145 11370 110179771
Axonal neuropathy 13.05 10.35 27 398131 2291 110188850
Hyperlipasaemia 13.03 10.35 21 398137 1468 110189673
Secondary hyperthyroidism 12.98 10.35 7 398151 112 110191029
Linear IgA disease 12.95 10.35 40 398118 4349 110186792
Small fibre neuropathy 12.95 10.35 17 398141 986 110190155
Spondylitis 12.95 10.35 13 398145 11325 110179816
Haematoma infection 12.92 10.35 22 398136 1610 110189531
Large intestine polyp 12.91 10.35 96 398062 15021 110176120
Osteonecrosis 12.90 10.35 70 398088 33671 110157470
Perihepatic abscess 12.88 10.35 8 398150 169 110190972
Cell death 12.88 10.35 48 398110 5743 110185398
Failure to suspend medication 12.86 10.35 12 398146 474 110190667
Dilatation ventricular 12.84 10.35 38 398120 4037 110187104
Aortic valve calcification 12.82 10.35 16 398142 882 110190259
Mechanical urticaria 12.81 10.35 13 398145 570 110190571
Cardiorenal syndrome 12.80 10.35 24 398134 1894 110189247
Cholecystectomy 12.80 10.35 12 398146 10797 110180344
Myoclonus 12.78 10.35 178 397980 32820 110158321
Rebound effect 12.75 10.35 21 398137 14785 110176356
Gastrointestinal ulcer haemorrhage 12.74 10.35 22 398136 1628 110189513
Erythema multiforme 12.74 10.35 124 398034 20973 110170168
Blood lactic acid increased 12.69 10.35 99 398059 15722 110175419
Diffuse vasculitis 12.66 10.35 7 398151 118 110191023
Blood glucose increased 12.66 10.35 591 397567 131905 110059236
Cardiac autonomic neuropathy 12.65 10.35 6 398152 72 110191069
Cardiovascular somatic symptom disorder 12.64 10.35 5 398153 37 110191104
Pancreatitis 12.59 10.35 249 397909 93284 110097857
Cardiac ventricular thrombosis 12.56 10.35 32 398126 3115 110188026
Pericarditis constrictive 12.53 10.35 17 398141 1018 110190123
Infected skin ulcer 12.50 10.35 37 398121 3930 110187211
Right ventricular dysfunction 12.45 10.35 33 398125 3290 110187851
Total lung capacity decreased 12.45 10.35 5 398153 7109 110184032
Postural tremor 12.44 10.35 17 398141 1025 110190116
Cholangitis 12.43 10.35 101 398057 16234 110174907
Basilar artery thrombosis 12.39 10.35 11 398147 407 110190734
Constipation 12.38 10.35 1114 397044 356672 109834469
Blood pressure ambulatory increased 12.37 10.35 6 398152 76 110191065
Hyperkinesia 12.31 10.35 32 398126 3152 110187989
Underdose 12.31 10.35 158 398000 63396 110127745
Skin necrosis 12.29 10.35 125 398033 21387 110169754
Testicular oedema 12.23 10.35 6 398152 78 110191063
Lichenoid keratosis 12.20 10.35 50 398108 6252 110184889
Colorectal cancer 12.17 10.35 9 398149 9105 110182036
Splenic necrosis 12.17 10.35 8 398150 187 110190954
Intermittent claudication 12.13 10.35 35 398123 3666 110187475
Pulmonary vein occlusion 12.11 10.35 7 398151 129 110191012
Coronary artery restenosis 12.10 10.35 18 398140 1174 110189967
Mite allergy 12.07 10.35 3 398155 5800 110185341
Drug screen positive 12.07 10.35 4 398154 6406 110184735
Administration site discomfort 12.06 10.35 8 398150 190 110190951
C-reactive protein decreased 12.05 10.35 30 398128 2879 110188262
Jaundice cholestatic 12.04 10.35 92 398066 14516 110176625
Eyelid retraction 12.03 10.35 6 398152 81 110191060
Gait disturbance 11.97 10.35 851 397307 277357 109913784
Nephroangiosclerosis 11.97 10.35 11 398147 426 110190715
Haematocrit abnormal 11.96 10.35 22 398136 1711 110189430
Joint dislocation 11.96 10.35 73 398085 34117 110157024
Nephrogenic anaemia 11.95 10.35 40 398118 4537 110186604
Vascular device infection 11.95 10.35 26 398132 16486 110174655
Obstructive airways disorder 11.94 10.35 233 397925 45916 110145225
Humerus fracture 11.94 10.35 73 398085 10703 110180438
Blood immunoglobulin E increased 11.92 10.35 56 398102 7426 110183715
Depressed mood 11.91 10.35 295 397863 60514 110130627
Sinus arrhythmia 11.89 10.35 25 398133 2145 110188996
Ligament sprain 11.88 10.35 25 398133 16043 110175098
Inhibitory drug interaction 11.84 10.35 42 398116 4905 110186236
Thyroiditis 11.83 10.35 51 398107 6522 110184619
Meningioma surgery 11.82 10.35 3 398155 3 110191138
Craniofacial injury 11.82 10.35 3 398155 3 110191138
Pacemaker generated arrhythmia 11.82 10.35 3 398155 3 110191138
Small cell carcinoma 11.80 10.35 10 398148 347 110190794
Neonatal gastrointestinal disorder 11.80 10.35 5 398153 45 110191096
Reticulocytosis 11.80 10.35 13 398145 627 110190514
Cannabinoid hyperemesis syndrome 11.77 10.35 6 398152 85 110191056
Electrocardiogram repolarisation abnormality 11.76 10.35 26 398132 2309 110188832
Dysuria 11.74 10.35 292 397866 59939 110131202
Left ventricle outflow tract obstruction 11.73 10.35 12 398146 531 110190610
Pseudohyponatraemia 11.70 10.35 8 398150 200 110190941
Drug specific antibody present 11.70 10.35 8 398150 8426 110182715
Cheyne-Stokes respiration 11.67 10.35 12 398146 534 110190607
Hepatic calcification 11.61 10.35 10 398148 355 110190786
Glycosylated haemoglobin decreased 11.60 10.35 15 398143 857 110190284
Retinal phototoxicity 11.59 10.35 4 398154 19 110191122
Tooth infection 11.59 10.35 41 398117 22175 110168966
Pulmonary congestion 11.57 10.35 166 397992 30800 110160341
Angiodysplasia 11.57 10.35 20 398138 1482 110189659
Immobilisation syndrome 11.55 10.35 15 398143 861 110190280
Platelet aggregation decreased 11.52 10.35 5 398153 48 110191093
Paresis cranial nerve 11.52 10.35 5 398153 48 110191093
Paradoxical drug reaction 11.51 10.35 11 398147 9806 110181335
Electrocardiogram ST segment abnormal 11.50 10.35 22 398136 1763 110189378
Infusion site extravasation 11.48 10.35 15 398143 11619 110179522
Thyroiditis acute 11.46 10.35 8 398150 207 110190934
Spinal stenosis 11.46 10.35 33 398125 19023 110172118
PCO2 decreased 11.45 10.35 31 398127 3130 110188011
Foetal heart rate disorder 11.43 10.35 5 398153 49 110191092
Pseudofolliculitis 11.43 10.35 4 398154 20 110191121
Apheresis related complication 11.43 10.35 4 398154 20 110191121
Relapsing-remitting multiple sclerosis 11.43 10.35 24 398134 2058 110189083
Anal polyp 11.41 10.35 6 398152 91 110191050
Post-traumatic headache 11.41 10.35 6 398152 91 110191050
Feeling of body temperature change 11.41 10.35 4 398154 6184 110184957
Kussmaul respiration 11.40 10.35 11 398147 453 110190688
Quality of life decreased 11.38 10.35 21 398137 14148 110176993
Osteomyelitis 11.36 10.35 81 398077 36519 110154622
Malignant neoplasm progression 11.35 10.35 513 397645 174054 110017087
Coma acidotic 11.35 10.35 7 398151 146 110190995
Bundle branch block 11.34 10.35 22 398136 1781 110189360
Electrocardiogram change 11.34 10.35 19 398139 1372 110189769
Osteocalcin decreased 11.34 10.35 5 398153 50 110191091
Hypomania 11.33 10.35 12 398146 10198 110180943
Generalised tonic-clonic seizure 11.32 10.35 134 398024 54546 110136595
Prothrombin level decreased 11.28 10.35 22 398136 1788 110189353
Cardiac disorder 11.28 10.35 357 397801 75923 110115218
Anal paraesthesia 11.27 10.35 4 398154 21 110191120
Serratia infection 11.21 10.35 25 398133 2234 110188907
Injection site mass 11.19 10.35 48 398110 24565 110166576
Vitamin D deficiency 11.18 10.35 109 398049 18443 110172698
Urinary straining 11.17 10.35 5 398153 52 110191089
Paraparesis 11.13 10.35 39 398119 4527 110186614
Femoral artery aneurysm 11.13 10.35 8 398150 217 110190924
Orbital swelling 11.13 10.35 6 398152 96 110191045
Left atrial volume increased 11.07 10.35 6 398152 97 110191044
Pustular psoriasis 11.07 10.35 20 398138 13585 110177556
Hypertensive cardiomyopathy 11.04 10.35 10 398148 380 110190761
Intracranial pressure increased 11.01 10.35 13 398145 10522 110180619
Mucosal membrane hyperplasia 11.01 10.35 5 398153 54 110191087
Cytomegalovirus chorioretinitis 10.94 10.35 6 398152 7122 110184019
Pancreatic neuroendocrine tumour 10.93 10.35 15 398143 908 110190233
Dermatitis contact 10.92 10.35 21 398137 13932 110177209
Human herpesvirus 6 infection 10.92 10.35 5 398153 6576 110184565
Reflexes abnormal 10.90 10.35 16 398142 1031 110190110
Intracardiac thrombus 10.88 10.35 37 398121 4231 110186910
Adrenomegaly 10.88 10.35 11 398147 480 110190661
Poikiloderma 10.86 10.35 11 398147 481 110190660
Pulmonary vasculitis 10.86 10.35 5 398153 6555 110184586
Bronchopulmonary aspergillosis 10.85 10.35 63 398095 29800 110161341
Blood immunoglobulin G decreased 10.84 10.35 3 398155 5397 110185744
Thinking abnormal 10.82 10.35 24 398134 15116 110176025
Device pacing issue 10.82 10.35 7 398151 159 110190982
Parkinsonian rest tremor 10.82 10.35 10 398148 390 110190751
Syringe issue 10.79 10.35 11 398147 9514 110181627
Hyperleukocytosis 10.77 10.35 32 398126 3407 110187734
Pancreatitis chronic 10.77 10.35 38 398120 4427 110186714
Pre-existing condition improved 10.76 10.35 5 398153 6521 110184620
Macroangiopathy 10.75 10.35 7 398151 161 110190980
Vaginal haemorrhage 10.74 10.35 50 398108 25024 110166117
Idiopathic pulmonary fibrosis 10.73 10.35 41 398117 4963 110186178
Pericardial fibrosis 10.73 10.35 8 398150 230 110190911
Foreign body in throat 10.72 10.35 16 398142 1047 110190094
Bipolar disorder 10.66 10.35 10 398148 8997 110182144
Pneumatosis intestinalis 10.66 10.35 9 398149 8520 110182621
Paroxysmal arrhythmia 10.62 10.35 5 398153 59 110191082
Primary familial hypomagnesaemia 10.62 10.35 3 398155 6 110191135
Mouth haemorrhage 10.59 10.35 84 398074 13404 110177737
Prohormone brain natriuretic peptide increased 10.59 10.35 10 398148 401 110190740
Intra-abdominal haematoma 10.58 10.35 32 398126 3440 110187701
Foetal exposure during pregnancy 10.57 10.35 7 398151 7498 110183643
Tendon pain 10.56 10.35 48 398110 6278 110184863
Localised oedema 10.55 10.35 63 398095 9160 110181981
Coronary ostial stenosis 10.52 10.35 7 398151 167 110190974
Nocardiosis 10.52 10.35 7 398151 7479 110183662
Hormone receptor positive HER2 negative breast cancer 10.49 10.35 8 398150 238 110190903
Eye disorder 10.49 10.35 61 398097 28845 110162296
Dysphoria 10.48 10.35 5 398153 6423 110184718
Lymphocyte count decreased 10.47 10.35 144 398014 57099 110134042
Bladder irrigation 10.47 10.35 5 398153 61 110191080
Behaviour disorder 10.47 10.35 65 398093 9582 110181559
Ventricular flutter 10.46 10.35 6 398152 109 110191032
Vitamin B12 deficiency 10.45 10.35 67 398091 9988 110181153
Substance abuse 10.43 10.35 18 398140 12445 110178696
Mean cell haemoglobin increased 10.43 10.35 44 398114 5573 110185568
Systolic hypertension 10.43 10.35 15 398143 949 110190192
Cerebrovascular arteriovenous malformation 10.41 10.35 6 398152 110 110191031
Cardioactive drug level above therapeutic 10.41 10.35 8 398150 241 110190900
Crystalluria 10.38 10.35 18 398140 1337 110189804
Facial asymmetry 10.36 10.35 15 398143 955 110190186

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 39.61 31.76 49 270 3691 109943

Pharmacologic Action:

SourceCodeDescription
ATC C07AB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX04 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C09BX02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 ฮฒ-adrenergic antagonist
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:66991 sympatholytic agent
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D013565 Sympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists

Related Drugs by ATC class:

C07AB Beta blocking agents, selective 13 drugs
acebutololatenololbetaxololbevantololceliprololepanololesatenololesmolollandiololmetoprololnebivololpractolol show all 13 →
C07BB Beta blocking agents, selective, and thiazides 5 drugs
acebutololatenololbevantololmetoprololnebivolol
C07FB Beta blocking agents and calcium channel blockers 6 drugs
amlodipineatenololfelodipinemetoprololnebivololnifedipine
C07FX Beta blocking agents, other combinations 6 drugs
acetylsalicylic acidcarvedilolivabradinemetoprololpropranololsotalol
C09BX ACE inhibitors, other combinations 7 drugs
amlodipinehydrochlorothiazideindapamidenebivololperindoprilramiprilzofenopril

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Chronic heart failure off-label use 48447003
Angina pectoris off-label use 194828000
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Severe chronic obstructive pulmonary disease contraindication 313299006
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.65 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.94 WOMBAT-PK
Beta-3 adrenergic receptor GPCR Ki 5.04 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 8.28 CHEMBL

External reference:

IDSource
4023923 VUID
N0000021928 NUI
D00634 KEGG_DRUG
104344-23-2 SECONDARY_CAS_RN
142146 RXNORM
C0053799 UMLSCUI
CHEBI:3127 CHEBI
CHEMBL645 ChEMBL_ID
CHEMBL1472989 ChEMBL_ID
DB00612 DRUGBANK_ID
D017298 MESH_DESCRIPTOR_UI
2405 PUBCHEM_CID
7129 IUPHAR_LIGAND_ID
5225 INN_ID
Y41JS2NL6U UNII
38369 MMSL
4291 MMSL
d00709 MMSL
108547003 SNOMEDCT_US
386868003 SNOMEDCT_US
386869006 SNOMEDCT_US
4020862 VANDF
4023923 VANDF
003703 NDDF
003704 NDDF
Y41JS2NL6U INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 2.50 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 5 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0501 TABLET, FILM COATED 2.50 mg ORAL ANDA 24 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0503 TABLET, FILM COATED 5 mg ORAL ANDA 24 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0505 TABLET, FILM COATED 10 mg ORAL ANDA 24 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-740 TABLET 2.50 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-741 TABLET 5 mg ORAL ANDA 19 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10135-742 TABLET 10 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-173 TABLET 2.50 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-174 TABLET 10 mg ORAL ANDA 20 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 10544-563 TABLET 5 mg ORAL ANDA 20 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-373 TABLET, FILM COATED 5 mg ORAL ANDA 11 sections
BISOPROLOL FUMARATE Human Prescription Drug Label 1 15955-374 TABLET, FILM COATED 10 mg ORAL ANDA 11 sections
Bisoprolol Fumarate Human Prescription Drug Label 1 16714-529 TABLET, FILM COATED 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate Human Prescription Drug Label 1 16714-530 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-667 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 21695-670 TABLET 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-808 TABLET, COATED 5 mg ORAL ANDA 23 sections
Bisoprolol Fumarate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 21695-809 TABLET, COATED 10 mg ORAL ANDA 23 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-126 TABLET 5 mg ORAL ANDA 18 sections
Bisoprolol Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 29300-127 TABLET 10 mg ORAL ANDA 18 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-187 TABLET 2.50 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-188 TABLET 5 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 29300-189 TABLET 10 mg ORAL ANDA 19 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 33261-918 TABLET 5 mg ORAL ANDA 19 sections
Bisoprolol HUMAN PRESCRIPTION DRUG LABEL 1 42571-470 TABLET, FILM COATED 5 mg ORAL ANDA 18 sections
Bisoprolol HUMAN PRESCRIPTION DRUG LABEL 1 42571-471 TABLET, FILM COATED 10 mg ORAL ANDA 18 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 42799-920 TABLET, FILM COATED 2.50 mg ORAL ANDA 20 sections
Bisoprolol Fumarate and Hydrochlorothiazide Human Prescription Drug Label 2 42799-921 TABLET, FILM COATED 5 mg ORAL ANDA 20 sections