simvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 2445 79902-63-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • simvastatin
  • sinvacor
  • simvastol
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
  • Molecular weight: 418.57
  • Formula: C25H38O5
  • CLOGP: 4.48
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 72.83
  • ALOGS: -4.53
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.37 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,STK33,TEK,TGFBR1,ZAP70 31
kinase-selectivity-class AXL,GRK2 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.396 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.867 % High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1991 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 2560.35 9.60 1707 270125 49549 90307066
Myalgia 1346.95 9.60 2105 269727 173020 90183595
Drug interaction 1115.61 9.60 2520 269312 273933 90082682
Systemic lupus erythematosus 865.42 9.60 56 271776 361840 89994775
Pemphigus 854.51 9.60 28 271804 326836 90029779
Acute kidney injury 844.09 9.60 2488 269344 317899 90038716
Maternal exposure during pregnancy 839.87 9.60 63 271769 360000 89996615
Hand deformity 802.12 9.60 18 271814 296344 90060271
Blood creatine phosphokinase increased 775.83 9.60 713 271119 33310 90323305
Glossodynia 742.77 9.60 59 271773 321720 90034895
Synovitis 647.77 9.60 106 271726 329646 90026969
Duodenal ulcer perforation 608.42 9.60 11 271821 221277 90135338
Myocardial infarction 607.15 9.60 1118 270714 104854 90251761
Myopathy 595.69 9.60 417 271415 13101 90343514
Off label use 577.05 9.60 1564 270268 1100688 89255927
Drug ineffective 574.14 9.60 2181 269651 1382117 88974498
Folliculitis 558.38 9.60 11 271821 204342 90152273
Helicobacter infection 530.67 9.60 39 271793 226811 90129804
Treatment failure 517.97 9.60 136 271696 303792 90052823
Fall 504.50 9.60 2806 269026 479004 89877611
Wound 475.38 9.60 158 271674 302822 90053793
Infusion related reaction 474.18 9.60 336 271496 416444 89940171
Pericarditis 423.56 9.60 141 271691 270010 90086605
Hyponatraemia 421.88 9.60 1109 270723 132429 90224186
Contraindicated product administered 421.51 9.60 217 271615 319922 90036693
Discomfort 408.25 9.60 156 271676 274179 90082436
Arthropathy 407.71 9.60 302 271530 365940 89990675
Joint swelling 399.93 9.60 556 271276 502744 89853871
Exposure during pregnancy 394.27 9.60 113 271719 238297 90118318
Muscle injury 392.17 9.60 38 271794 176616 90179999
Coronary artery disease 382.55 9.60 488 271344 33135 90323480
Irritable bowel syndrome 380.72 9.60 79 271753 207369 90149246
Swelling 370.19 9.60 427 271405 418631 89937984
Psoriatic arthropathy 368.87 9.60 113 271719 228222 90128393
Sleep disorder due to general medical condition, insomnia type 355.29 9.60 6 271826 128688 90227927
Drug intolerance 343.09 9.60 507 271325 447084 89909531
Syncope 338.78 9.60 1020 270812 131643 90224972
C-reactive protein abnormal 336.03 9.60 10 271822 127419 90229196
Therapeutic product effect decreased 335.40 9.60 209 271623 277362 90079253
Lactic acidosis 332.20 9.60 566 271266 49897 90306718
Cerebrovascular accident 326.05 9.60 961 270871 122572 90234043
Rheumatoid factor positive 317.78 9.60 64 271768 171586 90185029
Hepatic enzyme increased 315.90 9.60 370 271462 360366 89996249
Rheumatoid arthritis 314.26 9.60 375 271457 362239 89994376
Product use issue 309.13 9.60 320 271512 329599 90027016
Nasopharyngitis 299.57 9.60 474 271358 406630 89949985
Fibromyalgia 291.04 9.60 127 271705 206142 90150473
Alopecia 287.76 9.60 664 271168 494407 89862208
Stomatitis 284.85 9.60 243 271589 274455 90082160
Hypoglycaemia 284.55 9.60 640 271192 69208 90287407
Ill-defined disorder 280.23 9.60 102 271730 184789 90171826
Transient ischaemic attack 272.04 9.60 475 271357 42701 90313914
Atrial fibrillation 271.27 9.60 950 270882 132661 90223954
Facet joint syndrome 262.07 9.60 7 271825 98382 90258233
Lower respiratory tract infection 255.90 9.60 225 271607 250434 90106181
Impaired healing 254.20 9.60 198 271634 234001 90122614
Blister 251.86 9.60 236 271596 254762 90101853
Hypersensitivity 251.33 9.60 626 271206 454051 89902564
Infection 249.28 9.60 440 271392 361654 89994961
Type 2 diabetes mellitus 248.27 9.60 151 271681 203093 90153522
Renal failure 245.11 9.60 907 270925 130100 90226515
Immune-mediated myositis 240.85 9.60 126 271706 2295 90354320
Gastrointestinal disorder 239.21 9.60 250 271582 256437 90100178
International normalised ratio increased 237.33 9.60 472 271360 46844 90309771
Dehydration 236.84 9.60 1182 270650 193265 90163350
Product prescribing error 236.30 9.60 366 271466 29779 90326836
Joint range of motion decreased 236.09 9.60 58 271774 135585 90221030
Abdominal discomfort 233.25 9.60 698 271134 476630 89879985
Gastrointestinal haemorrhage 233.25 9.60 697 271135 89551 90267064
Breast cancer stage III 232.81 9.60 4 271828 84443 90272172
Lip dry 218.11 9.60 24 271808 100931 90255684
Liver injury 217.88 9.60 120 271712 170447 90186168
Hyperkalaemia 214.77 9.60 549 271283 64415 90292200
Condition aggravated 210.22 9.60 995 270837 594550 89762065
Labelled drug-drug interaction medication error 205.61 9.60 236 271596 14346 90342269
Wound infection 204.74 9.60 36 271796 106366 90250249
Intentional product use issue 196.75 9.60 216 271616 216676 90139939
Bursitis 195.49 9.60 75 271757 131579 90225036
Angioedema 193.85 9.60 528 271304 64348 90292267
Dizziness 193.40 9.60 2653 269179 586631 89769984
Deep vein thrombosis postoperative 192.58 9.60 4 271828 70805 90285810
Cardiac failure congestive 191.92 9.60 692 271140 98002 90258613
Anaemia 188.91 9.60 1749 270083 351053 90005562
Grip strength decreased 185.55 9.60 28 271804 92548 90264067
Wheezing 183.82 9.60 268 271564 237812 90118803
Live birth 183.74 9.60 14 271818 79093 90277522
Blood glucose increased 182.81 9.60 665 271167 94581 90262034
Product use in unapproved indication 180.20 9.60 470 271362 335766 90020849
Sinusitis 171.59 9.60 496 271336 342592 90014023
Peripheral venous disease 171.40 9.60 24 271808 83897 90272718
Injury 169.83 9.60 205 271627 197144 90159471
Acute myocardial infarction 165.38 9.60 340 271492 34550 90322065
Liver function test abnormal 163.22 9.60 425 271407 50420 90306195
Prescribed overdose 152.79 9.60 51 271781 97574 90259041
Autoimmune disorder 152.01 9.60 24 271808 76720 90279895
Product monitoring error 148.19 9.60 117 271715 4427 90352188
Blood cholesterol increased 146.45 9.60 249 271583 207763 90148852
Adjustment disorder with depressed mood 144.20 9.60 6 271826 56747 90299868
Musculoskeletal stiffness 141.54 9.60 438 271394 296094 90060521
Night sweats 140.74 9.60 108 271724 128658 90227957
Bradycardia 137.57 9.60 557 271275 83290 90273325
Rash 134.26 9.60 1636 270196 794464 89562151
Blepharospasm 134.07 9.60 8 271824 55437 90301178
Haematochezia 133.44 9.60 492 271340 70421 90286194
Bone erosion 133.41 9.60 6 271826 53015 90303600
Diabetes mellitus inadequate control 131.51 9.60 216 271616 18468 90338147
Hypotension 129.91 9.60 1520 270312 323877 90032738
Muscular weakness 128.39 9.60 1059 270773 205607 90151008
Subarachnoid haemorrhage 127.40 9.60 208 271624 17696 90338919
Chronic lymphocytic leukaemia 126.33 9.60 92 271740 3078 90353537
Weight increased 123.99 9.60 740 271092 417187 89939428
Pregnancy 123.80 9.60 19 271813 62028 90294587
Carotid artery occlusion 123.77 9.60 122 271710 6220 90350395
Renal impairment 123.44 9.60 634 271198 104787 90251828
Asthenia 123.03 9.60 2266 269566 531485 89825130
Palmoplantar keratoderma 122.40 9.60 94 271738 3413 90353202
Lung disorder 122.36 9.60 162 271670 149721 90206894
Lower limb fracture 121.99 9.60 51 271781 84962 90271653
Cardiospasm 121.67 9.60 93 271739 3353 90353262
Hip arthroplasty 120.68 9.60 39 271793 76169 90280446
Obesity 119.82 9.60 85 271747 105422 90251193
Haematemesis 117.71 9.60 291 271541 33435 90323180
Lip swelling 117.09 9.60 316 271516 38294 90318321
Therapy non-responder 115.48 9.60 144 271688 136560 90220055
X-ray abnormal 114.75 9.60 5 271827 45419 90311196
Palpitations 114.28 9.60 752 271080 135976 90220639
Cerebral haemorrhage 112.27 9.60 290 271542 34232 90322383
Necrotising myositis 111.52 9.60 53 271779 778 90355837
Atrial tachycardia 110.94 9.60 112 271720 5878 90350737
Muscle twitching 109.04 9.60 231 271601 23971 90332644
Pruritus genital 108.71 9.60 98 271734 4460 90352155
Arteriosclerosis coronary artery 108.61 9.60 139 271693 9464 90347151
Sleep terror 108.49 9.60 97 271735 4367 90352248
Oedema peripheral 108.38 9.60 1217 270615 256698 90099917
Circulatory collapse 107.94 9.60 234 271598 24670 90331945
Urinary tract infection 104.48 9.60 1387 270445 304245 90052370
Onychomadesis 104.43 9.60 9 271823 45989 90310626
Blood creatinine increased 103.96 9.60 588 271244 100798 90255817
Urticaria 103.48 9.60 534 271298 312200 90044415
Sleep disorder 101.34 9.60 283 271549 197747 90158868
Inflammation 100.75 9.60 243 271589 178349 90178266
Chronic obstructive pulmonary disease 100.04 9.60 463 271369 73366 90283249
Disturbance in attention 97.29 9.60 337 271495 46772 90309843
Lethargy 96.93 9.60 411 271421 62728 90293887
Oedema 96.84 9.60 294 271538 200001 90156614
Sciatica 95.20 9.60 98 271734 101284 90255331
Nightmare 95.16 9.60 205 271627 21520 90335095
Blood pressure inadequately controlled 95.03 9.60 105 271727 6119 90350496
Pain 94.11 9.60 2274 269558 994067 89362548
Myositis 93.70 9.60 217 271615 23911 90332704
Hyperglycaemia 93.68 9.60 351 271481 50619 90305996
Cardiovascular disorder 93.64 9.60 155 271677 13337 90343278
Myelosuppression 93.06 9.60 23 271809 53568 90303047
Device expulsion 92.82 9.60 8 271824 40878 90315737
Hypoaesthesia 92.26 9.60 558 271274 313652 90042963
Melaena 91.05 9.60 270 271562 34527 90322088
Knee arthroplasty 90.59 9.60 70 271762 83112 90273503
Liver function test increased 90.41 9.60 73 271759 84782 90271833
Immunisation 87.68 9.60 64 271768 2149 90354466
Asthma 87.32 9.60 401 271431 241759 90114856
Dyspnoea 87.01 9.60 3345 268487 877610 89479005
Abortion spontaneous 86.77 9.60 27 271805 54029 90302586
Upper gastrointestinal haemorrhage 86.34 9.60 204 271628 22772 90333843
Angina pectoris 86.03 9.60 286 271546 38874 90317741
Mobility decreased 85.84 9.60 423 271409 250311 90106304
Hypokalaemia 85.79 9.60 680 271152 130436 90226179
Tension headache 85.41 9.60 109 271723 7400 90349215
Anosmia 82.01 9.60 123 271709 9725 90346890
Muscle atrophy 81.78 9.60 113 271719 8288 90348327
Urosepsis 80.31 9.60 189 271643 21043 90335572
Migraine 80.03 9.60 297 271535 190095 90166520
Mitral valve incompetence 79.29 9.60 195 271637 22329 90334286
Nail disorder 79.17 9.60 39 271793 59028 90297587
Presyncope 78.71 9.60 242 271590 31563 90325052
Hypercholesterolaemia 78.37 9.60 113 271719 100779 90255836
Chronic kidney disease 78.04 9.60 328 271504 49863 90306752
Ventricular tachycardia 77.72 9.60 205 271627 24503 90332112
Breast cancer stage II 77.33 9.60 8 271824 35326 90321289
Hyperhidrosis 76.99 9.60 684 271148 135621 90220994
Haemorrhage intracranial 76.91 9.60 152 271680 15010 90341605
Road traffic accident 76.48 9.60 128 271704 107498 90249117
Blindness 76.14 9.60 213 271619 26355 90330260
Laryngitis 75.17 9.60 29 271803 50724 90305891
Chest pain 74.87 9.60 1361 270471 318284 90038331
Febrile neutropenia 74.71 9.60 235 271597 158114 90198501
Hypertensive crisis 74.69 9.60 165 271667 17619 90338996
Unresponsive to stimuli 74.67 9.60 268 271564 37853 90318762
Sinus bradycardia 73.14 9.60 159 271673 16793 90339822
Angina unstable 72.44 9.60 98 271734 7045 90349570
Acute coronary syndrome 72.08 9.60 122 271710 10691 90345924
Feeling abnormal 71.96 9.60 793 271039 166442 90190173
Alanine aminotransferase increased 71.09 9.60 602 271230 117736 90238879
Facial pain 70.34 9.60 135 271697 13047 90343568
Pancreatitis acute 70.06 9.60 234 271598 31881 90324734
Sleep disorder due to a general medical condition 68.90 9.60 24 271808 44714 90311901
Loss of consciousness 68.83 9.60 683 271149 139555 90217060
Taste disorder 68.03 9.60 51 271781 61495 90295120
Diplopia 67.85 9.60 215 271617 28499 90328116
Drug ineffective for unapproved indication 67.72 9.60 60 271772 66584 90290031
Coronary artery occlusion 67.22 9.60 104 271728 8450 90348165
Onychomycosis 66.95 9.60 15 271817 37361 90319254
Gait disturbance 65.92 9.60 1123 270709 259373 90097242
Lower gastrointestinal haemorrhage 65.57 9.60 105 271727 8787 90347828
Tremor 65.30 9.60 725 271107 152448 90204167
Osteoarthritis 64.25 9.60 335 271497 195395 90161220
Tachyarrhythmia 63.91 9.60 80 271752 5326 90351289
Haematuria 63.71 9.60 240 271592 34697 90321918
Therapeutic product effect incomplete 63.57 9.60 332 271500 193564 90163051
Haematoma 62.91 9.60 258 271574 38790 90317825
Exostosis 62.73 9.60 41 271791 53093 90303522
Swollen tongue 62.10 9.60 288 271544 45668 90310947
Subdural haematoma 61.69 9.60 147 271685 16498 90340117
Disorientation 61.50 9.60 279 271553 43835 90312780
Hallucination 60.79 9.60 372 271460 65587 90291028
Haemoglobin decreased 60.78 9.60 748 271084 161208 90195407
Back injury 60.67 9.60 32 271800 46590 90310025
Femoral neck fracture 59.84 9.60 109 271723 10124 90346491
Coronary artery stenosis 59.20 9.60 76 271756 5190 90351425
Tendon rupture 58.61 9.60 102 271730 9141 90347474
Head injury 58.33 9.60 216 271616 30972 90325643
Chromaturia 58.13 9.60 157 271675 19030 90337585
Ischaemic stroke 58.00 9.60 172 271660 21994 90334621
Arrhythmia 57.72 9.60 266 271566 42066 90314549
Epilepsy 57.27 9.60 99 271733 82107 90274508
Pyrexia 57.19 9.60 1526 270306 658959 89697656
Cognitive disorder 56.91 9.60 380 271452 69027 90287588
Blood glucose decreased 56.80 9.60 177 271655 23252 90333363
Liver disorder 56.47 9.60 181 271651 121088 90235527
Femoral hernia incarcerated 56.12 9.60 42 271790 1466 90355149
Disability 55.99 9.60 26 271806 40719 90315896
Pain in extremity 55.88 9.60 1757 270075 448772 89907843
C-reactive protein increased 54.85 9.60 319 271513 181070 90175545
Walking aid user 54.76 9.60 19 271813 35487 90321128
Muscle necrosis 54.27 9.60 33 271799 811 90355804
Exercise tolerance decreased 54.09 9.60 88 271744 7463 90349152
Peripheral swelling 53.48 9.60 894 270938 412212 89944403
Peripheral vascular disorder 53.09 9.60 80 271752 6351 90350264
Tinnitus 53.09 9.60 263 271569 42839 90313776
Adverse reaction 53.07 9.60 12 271820 29700 90326915
Blood loss anaemia 53.07 9.60 103 271729 10037 90346578
Polymyositis 52.26 9.60 47 271785 2132 90354483
Injection site reaction 52.13 9.60 125 271707 91955 90264660
Hyperlipidaemia 51.79 9.60 169 271663 22747 90333868
Carotid arteriosclerosis 51.73 9.60 37 271795 1203 90355412
Balance disorder 51.17 9.60 480 271352 96600 90260015
Aspartate aminotransferase increased 50.83 9.60 502 271330 102435 90254180
Nausea 50.52 9.60 3923 267909 1106393 89250222
Diverticulum 50.43 9.60 112 271720 12001 90344614
Aortic arteriosclerosis 50.30 9.60 86 271746 7598 90349017
Coeliac disease 49.26 9.60 37 271795 44573 90312042
Pain of skin 49.13 9.60 132 271700 15950 90340665
Hepatic cyst 49.04 9.60 78 271754 6490 90350125
Cutaneous T-cell dyscrasia 48.83 9.60 15 271817 57 90356558
Amnesia 48.73 9.60 519 271313 107986 90248629
Left ventricular hypertrophy 48.70 9.60 75 271757 6069 90350546
Lymphatic fistula 48.47 9.60 38 271794 1423 90355192
Ear infection 47.72 9.60 85 271747 69690 90286925
Sinus node dysfunction 47.09 9.60 69 271763 5343 90351272
Hepatic cirrhosis 47.03 9.60 73 271759 63180 90293435
Finger deformity 46.76 9.60 20 271812 32877 90323738
Hypothermia 46.74 9.60 127 271705 15448 90341167
Pancreatic steatosis 46.63 9.60 39 271793 1603 90355012
Myoglobin blood increased 46.44 9.60 38 271794 1514 90355101
High density lipoprotein decreased 46.25 9.60 48 271784 2603 90354012
Wound dehiscence 46.05 9.60 71 271761 5751 90350864
Pulmonary embolism 46.01 9.60 597 271235 130223 90226392
Hip fracture 45.96 9.60 209 271623 32868 90323747
Arteriosclerosis 45.92 9.60 101 271731 10752 90345863
Blood urea increased 45.92 9.60 197 271635 30216 90326399
Speech disorder 45.80 9.60 263 271569 45322 90311293
Vasculitis 45.69 9.60 161 271671 22532 90334083
Haemarthrosis 45.46 9.60 58 271774 3936 90352679
Electrocardiogram QT prolonged 45.32 9.60 372 271460 72084 90284531
Faeces discoloured 45.31 9.60 154 271678 21166 90335449
Drug hypersensitivity 44.97 9.60 1053 270779 462556 89894059
Diabetic ketoacidosis 44.78 9.60 168 271664 24239 90332376
Haemodialysis 44.74 9.60 88 271744 8659 90347956
Vision blurred 44.71 9.60 517 271315 109776 90246839
Foetal death 44.56 9.60 5 271827 20718 90335897
Diverticulum intestinal 44.39 9.60 90 271742 9052 90347563
Quadriparesis 44.20 9.60 46 271786 2503 90354112
Drug resistance 44.11 9.60 18 271814 30431 90326184
Hallucination, visual 44.08 9.60 161 271671 22931 90333684
Malaise 44.04 9.60 2164 269668 583822 89772793
Tricuspid valve incompetence 43.94 9.60 130 271702 16601 90340014
Swelling face 43.76 9.60 404 271428 80948 90275667
Urinary retention 43.47 9.60 226 271606 37518 90319097
Malignant neoplasm progression 43.41 9.60 169 271663 106701 90249914
Foetal exposure during pregnancy 43.29 9.60 39 271793 42936 90313679
Diabetes mellitus 43.26 9.60 338 271494 64537 90292078
Peripheral arterial occlusive disease 43.26 9.60 61 271771 4560 90352055
Decorticate posture 43.25 9.60 21 271811 324 90356291
Intermittent claudication 43.09 9.60 39 271793 1784 90354831
Cerebral infarction 43.06 9.60 176 271656 26420 90330195
Chronic sinusitis 42.97 9.60 163 271669 23639 90332976
Myocardial ischaemia 42.82 9.60 114 271718 13700 90342915
Muscle spasms 42.72 9.60 1023 270809 250860 90105755
Dry mouth 42.64 9.60 350 271482 183709 90172906
Dysarthria 42.11 9.60 294 271538 54188 90302427
Diarrhoea 42.09 9.60 3315 268517 935875 89420740
Gastritis 42.02 9.60 241 271591 41512 90315103
Visual acuity reduced 42.01 9.60 160 271672 23250 90333365
Premature delivery 41.72 9.60 33 271799 38729 90317886
Ischaemic cardiomyopathy 41.49 9.60 45 271787 2568 90354047
Immunodeficiency 41.48 9.60 41 271791 43193 90313422
Torsade de pointes 40.86 9.60 119 271713 15063 90341552
Labile hypertension 40.66 9.60 23 271809 492 90356123
Seroma 40.59 9.60 48 271784 3012 90353603
Autoimmune hepatitis 40.08 9.60 93 271739 10258 90346357
Autoimmune myositis 39.83 9.60 20 271812 333 90356282
Wound infection pseudomonas 39.63 9.60 39 271793 1984 90354631
Blood sodium decreased 39.50 9.60 176 271656 27437 90329178
Femur fracture 39.41 9.60 255 271577 45827 90310788
Collagen disorder 39.35 9.60 18 271814 241 90356374
Loose tooth 38.94 9.60 52 271780 3691 90352924
Myocardial depression 38.79 9.60 24 271808 609 90356006
Lupus-like syndrome 38.63 9.60 54 271778 48792 90307823
Coronary artery thrombosis 38.53 9.60 30 271802 1112 90355503
Constipation 38.35 9.60 1107 270725 279288 90077327
Groin pain 38.07 9.60 101 271731 12112 90344503
Hiatus hernia 38.07 9.60 164 271668 25197 90331418
Muscle rupture 37.96 9.60 47 271785 3094 90353521
Ear pain 37.94 9.60 72 271760 57630 90298985
Ventricular extrasystoles 37.74 9.60 106 271726 13144 90343471
Illness 37.70 9.60 123 271709 81846 90274769
Parkinsonism 37.62 9.60 110 271722 13955 90342660
Glomerular filtration rate decreased 37.49 9.60 124 271708 16808 90339807
Cardiogenic shock 37.33 9.60 159 271673 24309 90332306
Atrioventricular block 37.26 9.60 82 271750 8733 90347882
Deep vein thrombosis 36.92 9.60 429 271403 91191 90265424
Vaginal flatulence 36.88 9.60 102 271730 12536 90344079
Pulmonary oedema 36.84 9.60 315 271517 61765 90294850
Muscle disorder 36.76 9.60 62 271770 5417 90351198
Hospitalisation 36.76 9.60 229 271603 127871 90228744
Carotid artery stenosis 36.64 9.60 61 271771 5273 90351342
Adverse drug reaction 36.48 9.60 203 271629 116498 90240117
Hypovolaemia 35.95 9.60 100 271732 12331 90344284
Arterial haemorrhage 35.85 9.60 41 271791 2482 90354133
Gouty tophus 35.62 9.60 17 271815 252 90356363
Drug abuse 35.54 9.60 127 271705 82220 90274395
Aortic valve stenosis 35.37 9.60 53 271779 4187 90352428
Oesophagitis 35.27 9.60 123 271709 17126 90339489
Haemorrhagic stroke 35.24 9.60 67 271765 6429 90350186
Facial paresis 35.17 9.60 51 271781 3912 90352703
Proctitis 34.91 9.60 113 271719 15146 90341469
Hypomagnesaemia 34.89 9.60 204 271628 35384 90321231
Cold sweat 34.71 9.60 107 271725 13974 90342641
Truncus arteriosus persistent 34.64 9.60 19 271813 382 90356233
Radiculopathy 34.47 9.60 128 271704 18377 90338238
Electrolyte imbalance 34.46 9.60 152 271680 23593 90333022
Myopathy toxic 34.41 9.60 22 271810 592 90356023
Incorrect route of product administration 34.33 9.60 62 271770 50564 90306051
Vertigo 34.23 9.60 340 271492 69471 90287144
Anuria 34.14 9.60 110 271722 14708 90341907
Crystal nephropathy 34.06 9.60 28 271804 1123 90355492
Lichenoid keratosis 34.03 9.60 40 271792 2494 90354121
Colitis microscopic 33.49 9.60 91 271741 11068 90345547
Cardiac disorder 33.45 9.60 288 271544 56584 90300031
Product substitution issue 33.07 9.60 124 271708 17884 90338731
Foot deformity 32.96 9.60 82 271750 59569 90297046
Jaundice 32.92 9.60 188 271644 32329 90324286
Nail ridging 32.76 9.60 20 271812 495 90356120
Rectal haemorrhage 32.70 9.60 386 271446 82358 90274257
Temperature regulation disorder 32.69 9.60 3 271829 14576 90342039
Oedema mouth 32.60 9.60 38 271794 2348 90354267
Cytokine release syndrome 32.46 9.60 22 271810 27951 90328664
Rash papular 32.40 9.60 134 271698 20221 90336394
Faecaloma 32.25 9.60 86 271746 10345 90346270
Caesarean section 32.20 9.60 8 271824 18569 90338046
Electrocardiogram abnormal 31.94 9.60 85 271747 10213 90346402
Dysgeusia 31.88 9.60 268 271564 52292 90304323
Fear 31.82 9.60 116 271716 16506 90340109
Angioplasty 31.81 9.60 30 271802 1447 90355168
Abnormal loss of weight 31.75 9.60 66 271766 6757 90349858
Hemiparesis 31.59 9.60 183 271649 31636 90324979
Paraesthesia oral 31.38 9.60 182 271650 31477 90325138
Tachycardia 30.99 9.60 654 271178 157019 90199596
Urinary incontinence 30.98 9.60 206 271626 37360 90319255
Glycosylated haemoglobin increased 30.98 9.60 110 271722 15452 90341163
Cardiac failure 30.62 9.60 480 271352 109016 90247599
Extrasystoles 30.26 9.60 58 271774 5599 90351016
Haemophagocytic lymphohistiocytosis 30.24 9.60 5 271827 15454 90341161
Nodular rash 30.18 9.60 14 271818 194 90356421
Ageusia 29.78 9.60 111 271721 15965 90340650
Cerebrospinal fluid retention 29.70 9.60 11 271821 82 90356533
Food allergy 29.62 9.60 20 271812 25458 90331157
Pulmonary fibrosis 29.40 9.60 195 271637 107308 90249307
International normalised ratio abnormal 29.17 9.60 46 271786 3799 90352816
Aortic stenosis 29.15 9.60 61 271771 6275 90350340
Arthralgia 29.05 9.60 1978 269854 776544 89580071
Pancreatitis 29.05 9.60 329 271503 69497 90287118
Back pain 28.95 9.60 1195 270637 315980 90040635
Blood triglycerides increased 28.89 9.60 99 271733 13662 90342953
Myoglobinuria 28.88 9.60 17 271815 393 90356222
Glycogen storage disease type V 28.87 9.60 6 271826 0 90356615
Therapy partial responder 28.87 9.60 15 271817 22028 90334587
Adverse event 28.70 9.60 220 271612 117198 90239417
Bundle branch block left 28.53 9.60 69 271763 7816 90348799
Epistaxis 28.48 9.60 385 271447 84740 90271875
Low density lipoprotein increased 28.46 9.60 70 271762 8015 90348600
Breath sounds abnormal 28.30 9.60 106 271726 15280 90341335
Abnormal dreams 28.17 9.60 86 271746 11171 90345444
Pulmonary hypertension 28.04 9.60 221 271611 42302 90314313
Sedation complication 28.03 9.60 8 271824 16936 90339679
Blood potassium increased 28.00 9.60 130 271702 20619 90335996
Gastric ulcer 27.99 9.60 159 271673 27289 90329326
Dysphagia 27.99 9.60 483 271349 111795 90244820
Female genital tract fistula 27.95 9.60 117 271715 17751 90338864
Product used for unknown indication 27.74 9.60 21 271811 746 90355869
Metabolic acidosis 27.71 9.60 272 271560 55404 90301211
Device difficult to use 27.69 9.60 9 271823 17516 90339099
Blood alkaline phosphatase increased 27.50 9.60 242 271590 47837 90308778
Low turnover osteopathy 27.34 9.60 47 271785 4171 90352444
Renal injury 27.29 9.60 80 271752 10163 90346452
International normalised ratio decreased 27.22 9.60 50 271782 4674 90351941
Eructation 27.11 9.60 83 271749 10799 90345816
Post viral fatigue syndrome 27.06 9.60 14 271818 249 90356366
Blood glucose fluctuation 27.05 9.60 52 271780 5031 90351584
Underdose 27.01 9.60 78 271754 53939 90302676
Pancreatic carcinoma 26.85 9.60 70 271762 8307 90348308
Systemic infection 26.84 9.60 50 271782 4725 90351890
Retinal artery thrombosis 26.83 9.60 10 271822 76 90356539
Diabetic hyperosmolar coma 26.80 9.60 16 271816 380 90356235
Serotonin syndrome 26.71 9.60 200 271632 37687 90318928
Joint destruction 26.66 9.60 4 271828 13283 90343332
Hypophagia 26.65 9.60 192 271640 35745 90320870
Postprandial hypoglycaemia 26.38 9.60 11 271821 116 90356499
Pancreatitis necrotising 26.20 9.60 34 271798 2347 90354268
Thrombosis 26.05 9.60 335 271497 72916 90283699
Congenital cardiovascular anomaly 25.84 9.60 17 271815 481 90356134
Gastroenteritis 25.77 9.60 163 271669 29066 90327549
Red blood cell sedimentation rate increased 25.63 9.60 144 271688 82451 90274164
Vascular stent stenosis 25.54 9.60 19 271813 657 90355958
Potentiating drug interaction 25.45 9.60 54 271778 5608 90351007
Skin laceration 25.37 9.60 149 271683 25886 90330729
Nervousness 25.28 9.60 182 271650 33874 90322741
Muscle spasticity 25.09 9.60 42 271790 35280 90321335
Musculoskeletal pain 25.03 9.60 362 271470 170889 90185726
Cerebral ischaemia 25.01 9.60 62 271770 7134 90349481
Prescribed underdose 24.82 9.60 128 271704 74891 90281724
Helicobacter gastritis 24.79 9.60 28 271804 1672 90354943
Chronic fatigue syndrome 24.73 9.60 27 271805 1552 90355063
Inappropriate antidiuretic hormone secretion 24.72 9.60 120 271712 19385 90337230
Sepsis 24.59 9.60 710 271122 179104 90177511
Apolipoprotein A-I decreased 24.56 9.60 7 271825 19 90356596
Illness anxiety disorder 24.47 9.60 11 271821 141 90356474
Coronary arterial stent insertion 24.41 9.60 36 271796 2804 90353811
Anal incontinence 24.40 9.60 105 271727 16125 90340490
Macular degeneration 24.31 9.60 196 271636 37774 90318841
Varicose vein 24.28 9.60 62 271770 7265 90349350
Respiratory disorder 24.13 9.60 106 271726 64710 90291905
Noninfective gingivitis 24.09 9.60 31 271801 2122 90354493
Toxic shock syndrome 24.02 9.60 22 271810 1022 90355593
Vulvovaginal burning sensation 23.91 9.60 34 271798 2561 90354054
Hypercalcaemia 23.72 9.60 180 271652 34060 90322555
Joint stiffness 23.71 9.60 137 271695 77905 90278710
Cardiomegaly 23.67 9.60 116 271716 18809 90337806
Orthostatic hypotension 23.65 9.60 210 271622 41617 90314998
Erythema dyschromicum perstans 23.65 9.60 9 271823 73 90356542
Ataxia 23.59 9.60 112 271720 17930 90338685
Cytomegalovirus infection 23.54 9.60 27 271805 26575 90330040
Listless 23.46 9.60 38 271794 3211 90353404
Gait inability 23.41 9.60 304 271528 146152 90210463
Subacute cutaneous lupus erythematosus 23.33 9.60 40 271792 3542 90353073
Inappropriate schedule of product administration 23.31 9.60 313 271519 149620 90206995
Disease progression 23.26 9.60 330 271502 156285 90200330
Neuropathy, ataxia, retinitis pigmentosa syndrome 23.08 9.60 8 271824 48 90356567
Osteoporosis 23.06 9.60 182 271650 96349 90260266
Pharyngeal oedema 22.98 9.60 92 271740 13679 90342936
Pre-eclampsia 22.93 9.60 3 271829 11045 90345570
Adrenal insufficiency 22.75 9.60 34 271798 29887 90326728
Premature labour 22.72 9.60 6 271826 13370 90343245
Brucellosis 22.45 9.60 9 271823 85 90356530
Depressed mood 22.44 9.60 240 271592 49982 90306633
Hypoglycaemic unconsciousness 22.43 9.60 19 271813 795 90355820
Duodenal ulcer repair 22.41 9.60 8 271824 53 90356562
Asphyxia 22.41 9.60 59 271773 7044 90349571
Carotid bruit 22.37 9.60 18 271814 700 90355915
Abdominal pain lower 22.24 9.60 161 271671 30016 90326599
Myoclonus 22.23 9.60 115 271717 19053 90337562
Spontaneous haematoma 22.08 9.60 22 271810 1136 90355479
Loss of personal independence in daily activities 21.94 9.60 282 271550 135823 90220792
Skin discolouration 21.81 9.60 216 271616 44099 90312516
Skin wrinkling 21.73 9.60 24 271808 1398 90355217
Dermatitis exfoliative 21.72 9.60 50 271782 5486 90351129
Aphasia 21.72 9.60 210 271622 42602 90314013
Activated partial thromboplastin time prolonged 21.70 9.60 62 271770 7763 90348852
Gestational diabetes 21.66 9.60 3 271829 10579 90346036
Faeces pale 21.55 9.60 28 271804 1935 90354680
Cardiac arrest 21.51 9.60 438 271394 104497 90252118
Mitochondrial myopathy 21.41 9.60 12 271820 252 90356363
Conjunctival discolouration 21.24 9.60 9 271823 99 90356516
Lacunar infarction 21.06 9.60 37 271795 3340 90353275
Cardiac septal defect 20.97 9.60 18 271814 767 90355848
Angiopathy 20.96 9.60 49 271783 5431 90351184
Bradyphrenia 20.81 9.60 60 271772 7552 90349063
Contraindicated product prescribed 20.79 9.60 25 271807 1597 90355018
Visual impairment 20.75 9.60 532 271300 131833 90224782
Ventricular hypokinesia 20.70 9.60 48 271784 5293 90351322
Dyslipidaemia 20.60 9.60 72 271760 10035 90346580
Poor venous access 20.54 9.60 17 271815 19510 90337105
Polyarthritis 20.54 9.60 15 271817 18335 90338280
Coronary artery bypass 20.51 9.60 30 271802 2319 90354296
Cerebrovascular disorder 20.51 9.60 33 271799 2773 90353842
Blood calcium increased 20.48 9.60 81 271751 11977 90344638
Ankylosing spondylitis 20.30 9.60 7 271825 13126 90343489
Ketoacidosis 20.29 9.60 49 271783 5546 90351069
Upper respiratory tract infection 20.27 9.60 267 271565 128051 90228564
Product dose omission in error 20.18 9.60 19 271813 20484 90336131
Supraventricular extrasystoles 20.10 9.60 47 271785 5210 90351405
Eye swelling 20.08 9.60 154 271678 29232 90327383
Colitis 20.08 9.60 308 271524 69634 90286981
Vaginal discharge 20.01 9.60 113 271719 19351 90337264
Subclavian vein thrombosis 19.91 9.60 28 271804 2088 90354527
Stress fracture 19.91 9.60 64 271768 8547 90348068
Diabetic neuropathy 19.84 9.60 43 271789 4531 90352084
Weight decreased 19.81 9.60 1358 270474 378552 89978063
Arterial stenosis 19.81 9.60 17 271815 724 90355891
Eye pruritus 19.77 9.60 152 271680 28875 90327740
Endocrine ophthalmopathy 19.74 9.60 20 271812 1054 90355561
Medical device site thrombosis 19.73 9.60 8 271824 78 90356537
Contusion 19.73 9.60 588 271244 250628 90105987
Tubulointerstitial nephritis 19.72 9.60 137 271695 25206 90331409
Gamma-glutamyltransferase increased 19.67 9.60 187 271645 37765 90318850
Sopor 19.64 9.60 134 271698 24510 90332105
Pernicious anaemia 19.62 9.60 18 271814 838 90355777
Sinus arrest 19.60 9.60 28 271804 2118 90354497
Multiple injuries 19.54 9.60 26 271806 1839 90354776
Osteonecrosis of external auditory canal 19.52 9.60 10 271822 174 90356441
Intraventricular haemorrhage 19.38 9.60 30 271802 2439 90354176
Amyotrophic lateral sclerosis 19.31 9.60 22 271810 1326 90355289
Fear of falling 19.27 9.60 16 271816 651 90355964
Blood creatine phosphokinase MB increased 19.18 9.60 21 271811 1211 90355404
Respiratory failure 19.17 9.60 478 271354 117940 90238675
Analgesic therapy 19.16 9.60 16 271816 656 90355959
Dialysis 19.16 9.60 76 271756 11253 90345362
Degenerative aortic valve disease 19.12 9.60 10 271822 182 90356433
Maternal exposure before pregnancy 19.10 9.60 5 271827 11208 90345407
Hand-eye coordination impaired 19.10 9.60 6 271826 25 90356590
Wrist fracture 19.00 9.60 95 271737 15529 90341086
Multiple drug therapy 18.92 9.60 55 271777 6954 90349661
Deafness 18.89 9.60 124 271708 22390 90334225
Fracture 18.78 9.60 122 271710 21954 90334661
Ejection fraction decreased 18.74 9.60 139 271693 26114 90330501
Confusional state 18.67 9.60 1372 270460 384833 89971782
Skin necrosis 18.52 9.60 100 271732 16841 90339774
Cerebellar infarction 18.51 9.60 28 271804 2230 90354385
Left ventricular failure 18.50 9.60 53 271779 6647 90349968
Cerebellar ataxia 18.48 9.60 18 271814 904 90355711
Apraxia 18.48 9.60 28 271804 2234 90354381
Left ventricular dysfunction 18.41 9.60 90 271742 14579 90342036
Anticoagulant therapy 18.38 9.60 17 271815 800 90355815
Diverticular perforation 18.16 9.60 37 271795 3735 90352880
Postoperative wound infection 18.03 9.60 84 271748 13342 90343273
Pallor 18.03 9.60 169 271663 33996 90322619
Coma scale abnormal 18.02 9.60 47 271785 5579 90351036
Osteonecrosis of jaw 18.00 9.60 188 271644 38915 90317700
Transient global amnesia 17.99 9.60 16 271816 715 90355900
Ubiquinone decreased 17.98 9.60 5 271827 12 90356603
Bundle branch block right 17.92 9.60 46 271786 5407 90351208
Aortic valve incompetence 17.90 9.60 52 271780 6572 90350043
Retinal coloboma 17.90 9.60 6 271826 32 90356583
Orthopnoea 17.84 9.60 53 271779 6782 90349833
Blood urine 17.80 9.60 13 271819 437 90356178
Ischaemia 17.75 9.60 45 271787 5250 90351365
Nasal ulcer 17.66 9.60 30 271802 2636 90353979
Carotid artery thrombosis 17.65 9.60 3 271829 9089 90347526
Leukocyturia 17.59 9.60 23 271809 1599 90355016
Antacid therapy 17.57 9.60 16 271816 738 90355877
Mitral valve sclerosis 17.55 9.60 9 271823 157 90356458
Mitral valve stenosis 17.50 9.60 21 271811 1338 90355277
Haemorrhage 17.50 9.60 299 271533 69070 90287545
Orbital swelling 17.47 9.60 7 271825 66 90356549
Electrocardiogram PR prolongation 17.47 9.60 17 271815 853 90355762
Rash pruritic 17.46 9.60 345 271487 81869 90274746
Amaurosis fugax 17.46 9.60 15 271817 640 90355975
Sodium retention 17.45 9.60 9 271823 159 90356456
Appendicolith 17.44 9.60 16 271816 745 90355870
Exfoliative rash 17.41 9.60 33 271799 3159 90353456
Brain stem infarction 17.40 9.60 17 271815 857 90355758
Cellulitis 17.34 9.60 377 271455 90960 90265655
Retinal haemorrhage 17.30 9.60 47 271785 5717 90350898
Brain contusion 17.26 9.60 15 271817 650 90355965
Febrile bone marrow aplasia 17.26 9.60 4 271828 9734 90346881
Body temperature decreased 17.21 9.60 28 271804 23788 90332827
Accidental exposure to product 17.20 9.60 67 271765 42299 90314316
Macroangiopathy 17.19 9.60 10 271822 226 90356389
Ulcer haemorrhage 17.17 9.60 33 271799 26288 90330327
Fracture displacement 17.16 9.60 20 271812 1236 90355379
Eosinophilic cellulitis 17.15 9.60 10 271822 227 90356388
Colitis ischaemic 17.14 9.60 78 271754 12268 90344347
Nephrogenic systemic fibrosis 17.12 9.60 38 271794 4070 90352545
Craniofacial fracture 17.12 9.60 13 271819 464 90356151
Diabetic metabolic decompensation 17.10 9.60 25 271807 1932 90354683
Oral candidiasis 17.05 9.60 172 271660 35283 90321332
Restlessness 17.04 9.60 173 271659 35547 90321068
Stevens-Johnson syndrome 16.87 9.60 148 271684 29228 90327387
Sensory disturbance 16.86 9.60 91 271741 15322 90341293
Lymph node palpable 16.86 9.60 8 271824 117 90356498
Fracture blisters 16.85 9.60 7 271825 73 90356542
Hypernatraemia 16.71 9.60 64 271768 9323 90347292
Iris coloboma 16.65 9.60 6 271826 41 90356574
Drug therapy 16.61 9.60 16 271816 793 90355822
Neutrophil count decreased 16.56 9.60 136 271696 71396 90285219
Urine viscosity increased 16.52 9.60 6 271826 42 90356573
Nasal polyps 16.47 9.60 6 271826 10874 90345741
Language disorder 16.47 9.60 29 271803 2623 90353992
COVID-19 16.47 9.60 383 271449 168460 90188155
Blood potassium decreased 16.43 9.60 217 271615 47510 90309105
Acetonaemia 16.42 9.60 11 271821 321 90356294
General symptom 16.41 9.60 12 271820 14656 90341959
Femoral artery embolism 16.40 9.60 6 271826 43 90356572
Cerebral artery occlusion 16.40 9.60 18 271814 1041 90355574
Radius fracture 16.40 9.60 37 271795 4007 90352608
Polymyalgia rheumatica 16.38 9.60 42 271790 4935 90351680
Blood glucose abnormal 16.31 9.60 64 271768 9428 90347187
Emotional distress 16.28 9.60 175 271657 36487 90320128
Dyspnoea exertional 16.26 9.60 306 271526 71982 90284633
Transplant rejection 16.24 9.60 9 271823 12749 90343866
Nasal dryness 16.23 9.60 45 271787 5538 90351077
Overlap syndrome 16.20 9.60 3 271829 8545 90348070
Sprue-like enteropathy 16.17 9.60 17 271815 936 90355679
Immobile 16.13 9.60 49 271783 6349 90350266
Fear of injection 16.12 9.60 3 271829 8512 90348103
Parakeratosis 15.89 9.60 11 271821 339 90356276
Labyrinthitis 15.87 9.60 29 271803 2700 90353915
No adverse event 15.85 9.60 129 271703 67853 90288762
Osteitis 15.84 9.60 35 271797 3738 90352877
Aortic disorder 15.78 9.60 16 271816 844 90355771
Haematotoxicity 15.73 9.60 9 271823 12526 90344089
End stage renal disease 15.72 9.60 59 271773 8512 90348103
Dysuria 15.65 9.60 184 271648 39217 90317398
Muscle contractions involuntary 15.64 9.60 30 271802 2898 90353717
Disease recurrence 15.63 9.60 59 271773 37594 90319021
Pemphigoid 15.63 9.60 61 271771 8965 90347650
Labelled drug-food interaction medication error 15.61 9.60 10 271822 270 90356345
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.60 9.60 36 271796 3957 90352658
Basal cell carcinoma 15.59 9.60 161 271671 33228 90323387
Non-cardiac chest pain 15.58 9.60 50 271782 6671 90349944
Nodal rhythm 15.56 9.60 23 271809 1795 90354820
Therapeutic response shortened 15.53 9.60 28 271804 22851 90333764
Gout 15.48 9.60 95 271737 16764 90339851
Burning sensation 15.46 9.60 272 271560 63180 90293435
Poliomyelitis 15.42 9.60 6 271826 52 90356563
Muscle strength abnormal 15.35 9.60 7 271825 93 90356522
Spondylitis 15.35 9.60 12 271820 14166 90342449
Long QT syndrome 15.34 9.60 36 271796 4001 90352614
Bladder trabeculation 15.22 9.60 6 271826 54 90356561
Hypoglycaemic coma 15.19 9.60 30 271802 2960 90353655
Necrosis 15.16 9.60 49 271783 6561 90350054
Cardiac flutter 15.12 9.60 39 271793 4599 90352016
Large intestine polyp 15.10 9.60 62 271770 9324 90347291
Genital swelling 15.08 9.60 8 271824 150 90356465
Pathogen resistance 15.06 9.60 3 271829 8112 90348503
Flatulence 15.05 9.60 190 271642 41177 90315438
Respiratory tract haemorrhage 15.04 9.60 12 271820 461 90356154
Drug tolerance 14.99 9.60 19 271813 17897 90338718
Product complaint 14.97 9.60 80 271752 13420 90343195
Atrial flutter 14.96 9.60 68 271764 10690 90345925
Vomiting 14.95 9.60 2634 269198 785659 89570956
Rhinalgia 14.95 9.60 27 271805 2491 90354124
Haemorrhagic fever 14.88 9.60 4 271828 8 90356607
Arthritis 14.83 9.60 385 271447 166930 90189685
Body height decreased 14.77 9.60 73 271759 11876 90344739
Peak expiratory flow rate abnormal 14.77 9.60 7 271825 102 90356513
Ventricular fibrillation 14.75 9.60 82 271750 13962 90342653
Coombs negative haemolytic anaemia 14.75 9.60 11 271821 382 90356233
Escherichia urinary tract infection 14.73 9.60 81 271751 13734 90342881
Paresis 14.73 9.60 28 271804 2686 90353929
Pancreatic carcinoma metastatic 14.68 9.60 26 271806 2362 90354253
Therapy interrupted 14.67 9.60 89 271743 50019 90306596
Gastric ulcer haemorrhage 14.65 9.60 42 271790 5269 90351346
Self esteem decreased 14.64 9.60 15 271817 801 90355814
Hypersensitivity vasculitis 14.63 9.60 36 271796 4123 90352492
Cerebral amyloid angiopathy 14.59 9.60 9 271823 227 90356388
Abscess jaw 14.54 9.60 20 271812 1461 90355154
Haemorrhagic erosive gastritis 14.48 9.60 12 271820 487 90356128
Cardiovascular insufficiency 14.45 9.60 21 271811 1614 90355001
Vulvar basal cell carcinoma 14.42 9.60 5 271827 30 90356585
Facial nerve disorder 14.41 9.60 13 271819 592 90356023
Medication error 14.39 9.60 344 271488 84308 90272307
Gingivitis 14.38 9.60 61 271771 9308 90347307
Obsessive thoughts 14.36 9.60 13 271819 595 90356020
Occult blood positive 14.34 9.60 35 271797 3988 90352627
Haematocrit decreased 14.32 9.60 190 271642 41642 90314973
Atrioventricular block first degree 14.32 9.60 57 271775 8454 90348161
Peripheral embolism 14.31 9.60 19 271813 1341 90355274
Coagulopathy 14.25 9.60 119 271713 23170 90333445
Low density lipoprotein abnormal 14.17 9.60 10 271822 318 90356297
Inflammatory marker increased 14.15 9.60 60 271772 9154 90347461
Peripheral artery stenosis 14.14 9.60 13 271819 607 90356008
Pancreatitis relapsing 14.14 9.60 19 271813 1357 90355258
Respiratory tract congestion 14.13 9.60 39 271793 27371 90329244
Blood creatine phosphokinase abnormal 14.06 9.60 10 271822 322 90356293
Heavy menstrual bleeding 14.05 9.60 25 271807 20505 90336110
Hypertensive heart disease 14.04 9.60 27 271805 2613 90354002
Tumour lysis syndrome 14.01 9.60 8 271824 11144 90345471
Mouth swelling 13.93 9.60 43 271789 5619 90350996
Peripheral ischaemia 13.91 9.60 43 271789 5624 90350991
Infarction 13.85 9.60 29 271803 2984 90353631
Restless legs syndrome 13.85 9.60 115 271717 22355 90334260
Antineutrophil cytoplasmic antibody positive 13.80 9.60 14 271818 739 90355876
Ocular myasthenia 13.78 9.60 8 271824 180 90356435
Prothrombin time prolonged 13.76 9.60 62 271770 9710 90346905
Blood phosphorus increased 13.76 9.60 36 271796 4282 90352333
Panic attack 13.71 9.60 130 271702 26235 90330380
Eye injury 13.71 9.60 8 271824 11012 90345603
Therapeutic response decreased 13.70 9.60 188 271644 89541 90267074
Electrocardiogram T wave abnormal 13.70 9.60 27 271805 2661 90353954
Eye irritation 13.64 9.60 159 271673 33819 90322796
Pleural effusion 13.64 9.60 436 271396 111555 90245060
Fluid intake reduced 13.62 9.60 35 271797 4117 90352498
Dementia 13.59 9.60 120 271712 23741 90332874
Gingival hypertrophy 13.59 9.60 24 271808 2176 90354439
Blindness transient 13.59 9.60 37 271795 4506 90352109
Social avoidant behaviour 13.59 9.60 31 271801 3382 90353233
Movement disorder 13.58 9.60 140 271692 28879 90327736
Eyelid disorder 13.56 9.60 24 271808 2179 90354436
Peroneal nerve palsy 13.54 9.60 43 271789 5705 90350910
Injection site pain 13.52 9.60 407 271425 173292 90183323
Urine output decreased 13.51 9.60 74 271758 12529 90344086
Pollakiuria 13.50 9.60 155 271677 32850 90323765
Vulvovaginal pruritus 13.45 9.60 34 271798 3959 90352656
Skin candida 13.45 9.60 21 271811 1720 90354895
Embolism venous 13.45 9.60 32 271800 3588 90353027
Breast cancer stage I 13.44 9.60 6 271826 9618 90346997
Gastrooesophageal reflux disease 13.38 9.60 388 271444 165949 90190666
Tendon sheath incision 13.34 9.60 6 271826 77 90356538
Sudden cardiac death 13.34 9.60 24 271808 2208 90354407
Pustular psoriasis 13.24 9.60 22 271810 18534 90338081
Blood urine present 13.21 9.60 93 271739 17185 90339430
Enterococcal sepsis 13.20 9.60 20 271812 1596 90355019
Cardiac valve disease 13.12 9.60 37 271795 4598 90352017
Biopsy muscle abnormal 13.09 9.60 5 271827 41 90356574
Cardiac failure chronic 13.09 9.60 42 271790 5604 90351011
Perseveration 13.04 9.60 9 271823 276 90356339
Linear IgA disease 13.02 9.60 24 271808 2250 90354365
Duodenal ulcer 13.00 9.60 60 271772 9492 90347123
Intestinal ischaemia 12.99 9.60 57 271775 8826 90347789
Renal disorder 12.98 9.60 172 271660 37687 90318928
Neutropenia 12.94 9.60 547 271285 224357 90132258
Organising pneumonia 12.88 9.60 51 271781 7546 90349069
Myoglobin urine 12.86 9.60 4 271828 16 90356599
Hepatitis toxic 12.85 9.60 32 271800 3693 90352922
Toxicity to various agents 12.84 9.60 719 271113 287127 90069488
Acute respiratory distress syndrome 12.77 9.60 137 271695 28549 90328066
Agitation 12.75 9.60 277 271555 66821 90289794
Dilatation atrial 12.74 9.60 22 271810 1959 90354656
Infusion site pain 12.65 9.60 25 271807 19713 90336902
Pancreatitis chronic 12.65 9.60 27 271805 2816 90353799
Cholecystitis 12.61 9.60 91 271741 16949 90339666
Eyelid bleeding 12.59 9.60 5 271827 46 90356569
Motor neurone disease 12.59 9.60 8 271824 213 90356402
Cerebral ventricular rupture 12.56 9.60 8 271824 214 90356401
Spasmodic dysphonia 12.51 9.60 6 271826 90 90356525
Eye movement disorder 12.50 9.60 44 271788 6154 90350461
Granuloma annulare 12.48 9.60 14 271818 830 90355785
Blood pressure fluctuation 12.43 9.60 99 271733 52314 90304301
Meibomianitis 12.40 9.60 5 271827 48 90356567
Tessellated fundus 12.40 9.60 5 271827 48 90356567
Hypoacusis 12.40 9.60 133 271699 27717 90328898
Thrombosis in device 12.32 9.60 28 271804 3047 90353568
Normetanephrine urine increased 12.31 9.60 4 271828 19 90356596
Reversible ischaemic neurological deficit 12.31 9.60 4 271828 19 90356596
Spontaneous haemorrhage 12.30 9.60 13 271819 720 90355895
Cerebral arteriosclerosis 12.28 9.60 9 271823 304 90356311
Poisoning deliberate 12.28 9.60 19 271813 16467 90340148
Somnolence 12.26 9.60 755 271077 208329 90148286
Lipohypertrophy 12.21 9.60 13 271819 726 90355889
Tooth fracture 12.20 9.60 72 271760 12528 90344087
Q fever 12.16 9.60 7 271825 155 90356460
Wrong patient received product 12.13 9.60 30 271802 3447 90353168
Lung infiltration 12.12 9.60 83 271749 15199 90341416
Renal phospholipidosis 12.11 9.60 8 271824 228 90356387
Lipids abnormal 12.10 9.60 9 271823 311 90356304
Ophthalmoplegia 12.01 9.60 20 271812 1729 90354886
Degenerative mitral valve disease 11.98 9.60 4 271828 21 90356594
Haemothorax 11.97 9.60 24 271808 2394 90354221
Haemorrhagic transformation stroke 11.94 9.60 17 271815 1282 90355333
Gastric cyst 11.89 9.60 6 271826 101 90356514
Sedation 11.89 9.60 90 271742 48081 90308534
Hyperparathyroidism 11.86 9.60 29 271803 3308 90353307
Coronavirus test positive 11.81 9.60 14 271818 881 90355734
Plasma cell myeloma 11.80 9.60 180 271652 40648 90315967
Reflexes abnormal 11.79 9.60 13 271819 756 90355859
Vitreous haemorrhage 11.75 9.60 25 271807 2601 90354014
Spleen congestion 11.73 9.60 6 271826 104 90356511
Chronic gastritis 11.72 9.60 31 271801 3710 90352905
Adenocarcinoma pancreas 11.72 9.60 16 271816 1160 90355455
Cerebellar ischaemia 11.72 9.60 8 271824 241 90356374
Prerenal failure 11.70 9.60 22 271810 2093 90354522
Erythema 11.68 9.60 818 271014 228428 90128187
Ear pruritus 11.65 9.60 3 271829 6800 90349815
Oxalosis 11.64 9.60 5 271827 57 90356558
Microphthalmos 11.62 9.60 7 271825 169 90356446
Tenosynovitis 11.62 9.60 16 271816 14551 90342064
Erythromelalgia 11.60 9.60 9 271823 332 90356283
Dry skin 11.55 9.60 346 271486 87727 90268888
Drug monitoring procedure not performed 11.54 9.60 13 271819 774 90355841
Osteonecrosis 11.53 9.60 125 271707 26116 90330499
Abnormal sensation in eye 11.53 9.60 21 271811 1950 90354665
Emphysema 11.48 9.60 69 271763 12086 90344529
Carotid artery disease 11.45 9.60 19 271813 1638 90354977
Cardiac failure acute 11.45 9.60 68 271764 11861 90344754
Rhinorrhoea 11.44 9.60 191 271641 88125 90268490
Mental status changes 11.42 9.60 193 271639 44486 90312129
Mesenteric arterial occlusion 11.41 9.60 7 271825 175 90356440
Paralysis 11.38 9.60 66 271766 11412 90345203
Distributive shock 11.38 9.60 29 271803 3395 90353220
Blood pressure systolic abnormal 11.38 9.60 26 271806 19452 90337163
Chronic pigmented purpura 11.37 9.60 7 271825 176 90356439
Stent placement 11.36 9.60 33 271799 4170 90352445
Pulseless electrical activity 11.35 9.60 55 271777 8877 90347738
Urine analysis abnormal 11.35 9.60 38 271794 5183 90351432
Auricular swelling 11.34 9.60 5 271827 61 90356554
Electrocardiogram T wave peaked 11.32 9.60 8 271824 255 90356360
Product commingling 11.30 9.60 7 271825 178 90356437
Thyroid neoplasm 11.29 9.60 32 271800 3989 90352626
Diabetic retinopathy 11.27 9.60 25 271807 2677 90353938
Haemoptysis 11.26 9.60 151 271681 33169 90323446
Portal fibrosis 11.21 9.60 9 271823 349 90356266
Device issue 11.18 9.60 48 271784 29489 90327126
Abdominal pain 11.16 9.60 1353 270479 394368 89962247
Renal adenoma 11.16 9.60 3 271829 6 90356609
Suicide attempt 11.14 9.60 159 271673 75240 90281375
Skin pressure mark 11.14 9.60 4 271828 27 90356588
B-lymphocyte abnormalities 11.13 9.60 8 271824 262 90356353
Atrioventricular block second degree 11.13 9.60 34 271798 4418 90352197
Cerebral vasoconstriction 11.12 9.60 16 271816 1218 90355397
Monoparesis 11.11 9.60 21 271811 2006 90354609
Multiple organ dysfunction syndrome 11.10 9.60 276 271556 68060 90288555
Exposure to toxic agent 11.08 9.60 5 271827 7962 90348653
Oesophageal adenocarcinoma 11.06 9.60 7 271825 185 90356430
Neoplasm progression 11.03 9.60 83 271749 44403 90312212
Vestibular disorder 11.03 9.60 18 271814 1531 90355084
Cardioactive drug level increased 11.02 9.60 23 271809 2361 90354254
Pseudomonas bronchitis 11.02 9.60 4 271828 28 90356587
Mucosal inflammation 10.99 9.60 115 271717 57510 90299105
Injection site bruising 10.98 9.60 102 271730 52205 90304410
Product residue present 10.94 9.60 33 271799 4258 90352357
Device use error 10.90 9.60 4 271828 7217 90349398
Cardiac death 10.90 9.60 11 271821 577 90356038
Tetany 10.88 9.60 24 271808 2560 90354055
Androgenetic alopecia 10.83 9.60 7 271825 192 90356423
Azotaemia 10.82 9.60 38 271794 5310 90351305
Periorbital inflammation 10.77 9.60 7 271825 194 90356421
Micturition urgency 10.76 9.60 64 271768 11169 90345446
Intestinal angioedema 10.75 9.60 13 271819 835 90355780
Hyperreflexia 10.73 9.60 44 271788 6613 90350002
Facial bones fracture 10.69 9.60 30 271802 3717 90352898
Aspergillus infection 10.69 9.60 10 271822 10813 90345802
Cytomegalovirus infection reactivation 10.68 9.60 5 271827 7795 90348820
Wound treatment 10.64 9.60 7 271825 198 90356417
Increased appetite 10.61 9.60 66 271766 11699 90344916
Diverticulum intestinal haemorrhagic 10.61 9.60 19 271813 1742 90354873
Gastrointestinal ulcer 10.61 9.60 25 271807 2786 90353829
Sinus arrhythmia 10.53 9.60 17 271815 1432 90355183
Iatrogenic injury 10.51 9.60 13 271819 855 90355760
Breast atrophy 10.42 9.60 6 271826 133 90356482
Blood creatine increased 10.42 9.60 45 271787 6922 90349693
Lip pain 10.38 9.60 21 271811 2109 90354506
Hyponatriuria 10.35 9.60 4 271828 34 90356581
Hypomania 10.32 9.60 7 271825 8890 90347725
Osteopenia 10.31 9.60 110 271722 22892 90333723
Nephrosclerosis 10.31 9.60 15 271817 1154 90355461
Haemorrhoids 10.30 9.60 124 271708 26578 90330037
Skin fibrosis 10.27 9.60 13 271819 875 90355740
Complication of device removal 10.26 9.60 3 271829 6252 90350363
Anhedonia 10.23 9.60 64 271768 11367 90345248
Drug-induced liver injury 10.22 9.60 200 271632 90118 90266497
Salivary gland enlargement 10.22 9.60 9 271823 397 90356218
Aortic valve calcification 10.21 9.60 11 271821 623 90355992
Cough 10.21 9.60 1260 270572 367702 89988913
Heart disease congenital 10.20 9.60 18 271814 1631 90354984
Drug eruption 10.19 9.60 156 271676 35251 90321364
Vulvovaginal discomfort 10.19 9.60 24 271808 2673 90353942
Intentional dose omission 10.17 9.60 24 271808 17759 90338856
Peripheral coldness 10.17 9.60 74 271758 13818 90342797
Fear of death 10.13 9.60 15 271817 1172 90355443
Refusal of treatment by patient 10.12 9.60 39 271793 5699 90350916
Uterine perforation 10.10 9.60 5 271827 7549 90349066
Hiatus hernia strangulated 10.10 9.60 8 271824 304 90356311
Normochromic normocytic anaemia 10.10 9.60 36 271796 5066 90351549
Blood parathyroid hormone decreased 10.08 9.60 67 271765 12149 90344466
Therapeutic product effect prolonged 10.07 9.60 9 271823 405 90356210
Amylase increased 10.06 9.60 45 271787 7027 90349588
Endometrial hypertrophy 10.06 9.60 8 271824 306 90356309
Colonic haematoma 10.05 9.60 4 271828 37 90356578
Upper limb fracture 10.05 9.60 104 271728 21474 90335141
Apathy 10.00 9.60 62 271770 10978 90345637
Transaminases increased 10.00 9.60 162 271670 37030 90319585
Squamous cell carcinoma 9.96 9.60 58 271774 10043 90346572
Cachexia 9.96 9.60 44 271788 6834 90349781
Dysstasia 9.95 9.60 117 271715 24935 90331680
Diastolic dysfunction 9.94 9.60 46 271786 7287 90349328
Duodenal ulcer haemorrhage 9.94 9.60 23 271809 2533 90354082
Aggression 9.92 9.60 123 271709 26545 90330070
Genital haemorrhage 9.89 9.60 7 271825 8695 90347920
Eosinophilic pneumonia chronic 9.88 9.60 7 271825 224 90356391
Pathological fracture 9.88 9.60 56 271776 9604 90347011
Completed suicide 9.83 9.60 346 271486 144712 90211903
Anaemia postoperative 9.83 9.60 21 271811 2192 90354423
Cushingoid 9.81 9.60 10 271822 10385 90346230
Acne 9.79 9.60 48 271784 28459 90328156
Hepatic infection bacterial 9.78 9.60 4 271828 40 90356575
Alanine aminotransferase 9.76 9.60 5 271827 87 90356528
Drug half-life increased 9.74 9.60 6 271826 151 90356464
Dyspnoea paroxysmal nocturnal 9.73 9.60 14 271818 1066 90355549
Diverticulitis 9.72 9.60 190 271642 44997 90311618
Device dislocation 9.70 9.60 55 271777 31427 90325188
Granuloma skin 9.69 9.60 60 271772 10620 90345995
Hypothyroidism 9.68 9.60 218 271614 52909 90303706
Respiratory tract infection 9.67 9.60 122 271710 58956 90297659
Continuous haemodiafiltration 9.66 9.60 13 271819 930 90355685
Mitochondrial myopathy acquired 9.65 9.60 3 271829 12 90356603
Bronchopulmonary aspergillosis 9.63 9.60 12 271820 11386 90345229
Gastritis erosive 9.62 9.60 43 271789 6712 90349903
Calcitonin secretion disorder 9.61 9.60 4 271828 42 90356573

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 2838.45 11.16 2935 262756 75084 42280560
Myalgia 1334.68 11.16 2252 263439 93828 42261816
Off label use 1003.08 11.16 1525 264166 636810 41718834
Blood creatine phosphokinase increased 845.71 11.16 1260 264431 47078 42308566
Drug ineffective 813.99 11.16 1700 263991 628497 41727147
Myopathy 537.80 11.16 539 265152 13222 42342422
Drug interaction 449.58 11.16 3024 262667 263975 42091669
Myocardial infarction 444.04 11.16 1737 263954 122272 42233372
Febrile neutropenia 419.82 11.16 326 265365 185377 42170267
Drug abuse 373.63 11.16 96 265595 104675 42250969
Product use in unapproved indication 313.97 11.16 414 265277 184042 42171602
Acute kidney injury 302.50 11.16 3557 262134 363780 41991864
Coronary artery disease 279.00 11.16 852 264839 52868 42302776
Toxicity to various agents 248.48 11.16 675 265016 228461 42127183
Tendon rupture 243.87 11.16 276 265415 7807 42347837
Muscular weakness 226.48 11.16 1076 264615 82422 42273222
Treatment failure 223.92 11.16 57 265634 62567 42293077
Foetal exposure during pregnancy 221.25 11.16 20 265671 47291 42308353
Syncope 212.71 11.16 1199 264492 98207 42257437
Myositis 211.91 11.16 353 265338 14513 42341131
Dizziness 200.80 11.16 2405 263286 246849 42108795
Neutropenia 197.51 11.16 613 265078 198818 42156826
Cerebrovascular accident 191.66 11.16 1147 264544 96013 42259631
Myelosuppression 167.24 11.16 26 265665 40435 42315209
General physical health deterioration 165.57 11.16 1553 264138 149693 42205951
Therapeutic product effect incomplete 164.59 11.16 121 265570 70818 42284826
Death 161.86 11.16 2022 263669 469163 41886481
Drug ineffective for unapproved indication 155.71 11.16 47 265644 46116 42309528
Angina pectoris 154.45 11.16 504 265187 32392 42323252
Cardiac failure congestive 144.26 11.16 971 264720 84631 42271013
Pyrexia 143.93 11.16 1668 264023 392374 41963270
Liver function test abnormal 136.84 11.16 479 265212 31912 42323732
International normalised ratio increased 134.38 11.16 626 265065 47542 42308102
Muscle rupture 130.85 11.16 114 265577 2326 42353318
Drug resistance 130.73 11.16 27 265664 34221 42321423
Cytokine release syndrome 125.76 11.16 60 265631 44467 42311177
Disease progression 124.81 11.16 467 265224 143189 42212455
COVID-19 123.65 11.16 344 265347 115604 42240040
Asthenia 118.76 11.16 2431 263260 278362 42077282
Hospitalisation 118.11 11.16 175 265516 74155 42281489
Transient ischaemic attack 117.57 11.16 469 265222 33270 42322374
Cytomegalovirus infection 114.32 11.16 30 265661 32276 42323368
Chromaturia 114.16 11.16 285 265406 15704 42339940
Chest pain 111.93 11.16 1346 264345 138184 42217460
Inappropriate schedule of product administration 109.48 11.16 275 265416 95627 42260017
Immune-mediated myositis 108.48 11.16 126 265565 3667 42351977
Premature baby 107.67 11.16 10 265681 23143 42332501
Infusion related reaction 106.87 11.16 133 265558 60673 42294971
Myocardial ischaemia 106.84 11.16 297 265394 17465 42338179
Intentional product use issue 106.64 11.16 177 265514 71656 42283988
Acute myocardial infarction 106.63 11.16 674 265017 57491 42298153
Angioedema 105.50 11.16 534 265157 41943 42313701
Fall 104.97 11.16 2048 263643 232472 42123172
Malignant neoplasm progression 101.73 11.16 341 265350 108059 42247585
Chronic lymphocytic leukaemia 97.71 11.16 135 265556 4694 42350950
Therapy partial responder 94.85 11.16 8 265683 20013 42335631
Drug dependence 93.89 11.16 32 265659 29062 42326582
Blood glucose increased 93.55 11.16 782 264909 72917 42282727
Lip swelling 93.13 11.16 296 265395 18757 42336887
Product dose omission issue 91.99 11.16 574 265117 153791 42201853
Product use issue 90.80 11.16 216 265475 76535 42279109
Self esteem decreased 87.14 11.16 49 265642 473 42355171
Muscle spasms 86.88 11.16 869 264822 85175 42270469
Gastrointestinal haemorrhage 86.03 11.16 960 264731 96766 42258878
Condition aggravated 84 11.16 1133 264558 259621 42096023
Bronchopulmonary aspergillosis 83.75 11.16 11 265680 19418 42336226
Septic shock 82.21 11.16 294 265397 91378 42264266
Dehydration 81.60 11.16 1289 264402 140478 42215166
Cardiospasm 78.75 11.16 77 265614 1830 42353814
Pancytopenia 78.60 11.16 422 265269 117321 42238323
Dyspnoea 78.26 11.16 3438 262253 439183 41916461
Appendicolith 76.05 11.16 220 265471 13236 42342408
Mucosal inflammation 75.77 11.16 119 265572 49255 42306389
Amnesia 75.23 11.16 364 265327 28073 42327571
Carotid artery occlusion 74.21 11.16 110 265581 4084 42351560
Sleep terror 73.51 11.16 91 265600 2835 42352809
Atrial fibrillation 72.83 11.16 1249 264442 138344 42217300
Drug reaction with eosinophilia and systemic symptoms 71.88 11.16 94 265597 41981 42313663
Product prescribing error 71.80 11.16 338 265353 25774 42329870
Hypoglycaemia 71.69 11.16 627 265064 59227 42296417
Tension headache 69.92 11.16 96 265595 3318 42352326
Blood creatinine increased 69.77 11.16 1017 264674 108986 42246658
Pneumonia 69.74 11.16 2052 263639 420097 41935547
Pruritus genital 69.42 11.16 84 265607 2555 42353089
Pneumocystis jirovecii pneumonia 67.99 11.16 36 265655 25145 42330499
Renal failure 67.21 11.16 1264 264427 142462 42213182
Palmoplantar keratoderma 66.35 11.16 76 265615 2178 42353466
Oxygen saturation decreased 65.93 11.16 196 265495 64491 42291153
Coronary artery occlusion 65.26 11.16 183 265508 10814 42344830
Balance disorder 65.01 11.16 514 265177 47131 42308513
Therapy non-responder 64.84 11.16 148 265543 53211 42302433
No adverse event 64.81 11.16 89 265602 38932 42316712
Sleep disorder due to a general medical condition 64.09 11.16 15 265676 17438 42338206
Coronary artery stenosis 63.85 11.16 175 265516 10204 42345440
Injection site pain 61.93 11.16 171 265520 57627 42298017
Haemophagocytic lymphohistiocytosis 60.63 11.16 19 265672 18203 42337441
Gait disturbance 60.55 11.16 902 264789 97098 42258546
Thrombocytopenia 60.40 11.16 829 264862 189450 42166194
Product monitoring error 60.33 11.16 103 265588 4320 42351324
Therapeutic drug monitoring analysis not performed 59.64 11.16 40 265651 542 42355102
Agranulocytosis 59.16 11.16 62 265629 30550 42325094
Nasopharyngitis 58.87 11.16 296 265395 83700 42271944
Infection 58.61 11.16 433 265258 111635 42244009
Atrial tachycardia 58.58 11.16 98 265593 4042 42351602
Hepatic function abnormal 57.94 11.16 149 265542 51418 42304226
Thrombotic microangiopathy 57.78 11.16 11 265680 14771 42340873
Therapeutic response shortened 57.65 11.16 8 265683 13546 42342098
Muscle atrophy 57.56 11.16 147 265544 8214 42347430
Idiopathic pulmonary fibrosis 57.33 11.16 103 265588 4501 42351143
Confusional state 57.13 11.16 1408 264283 166189 42189455
Subdural haemorrhage 56.53 11.16 88 265603 3413 42352231
Angina unstable 56.08 11.16 178 265513 11270 42344374
Circulatory collapse 55.80 11.16 293 265398 23343 42332301
Rheumatoid arthritis 55.48 11.16 113 265578 42327 42313317
Quality of life decreased 55.46 11.16 111 265580 5265 42350379
Hyperkalaemia 55.07 11.16 754 264937 79704 42275940
Leukopenia 54.35 11.16 260 265431 74486 42281158
Immunisation 54.22 11.16 52 265639 1206 42354438
Coma 54.04 11.16 163 265528 53391 42302253
Obstructive airways disorder 53.90 11.16 45 265646 24714 42330930
Amyotrophic lateral sclerosis 53.76 11.16 49 265642 1063 42354581
Bone marrow failure 52.46 11.16 78 265613 33015 42322629
Myoglobinuria 52.35 11.16 42 265649 761 42354883
Venoocclusive liver disease 52.04 11.16 3 265688 10299 42345345
Orthostatic intolerance 50.90 11.16 43 265648 840 42354804
Tumour lysis syndrome 50.15 11.16 39 265652 22192 42333452
Transplant rejection 49.26 11.16 12 265679 13576 42342068
Productive cough 49.18 11.16 161 265530 51406 42304238
Loss of personal independence in daily activities 47.88 11.16 155 265536 49661 42305983
Haematuria 47.78 11.16 561 265130 57238 42298406
Frequent bowel movements 47.73 11.16 38 265653 21369 42334275
Dermatomyositis 47.69 11.16 55 265636 1588 42354056
Abnormal dreams 47.48 11.16 136 265555 8135 42347509
Cytopenia 47.26 11.16 25 265666 17472 42338172
Sedation 47.18 11.16 73 265618 30402 42325242
Posterior reversible encephalopathy syndrome 47.12 11.16 11 265680 12810 42342834
Low birth weight baby 47.10 11.16 4 265687 9951 42345693
Subarachnoid haemorrhage 47.10 11.16 197 265494 14275 42341369
Immune effector cell-associated neurotoxicity syndrome 47.05 11.16 3 265688 9458 42346186
Hepatic cytolysis 46.85 11.16 59 265632 26785 42328859
Respiratory depression 46.65 11.16 30 265661 18838 42336806
Facial pain 46.41 11.16 90 265601 4170 42351474
Pancreatitis acute 46.28 11.16 363 265328 33201 42322443
Epstein-Barr virus infection 45.72 11.16 4 265687 9714 42345930
Pseudomonas infection 45.65 11.16 21 265670 15902 42339742
Poisoning deliberate 45.50 11.16 5 265686 10129 42345515
Intentional overdose 45.46 11.16 166 265525 51290 42304354
Stomatitis 45.37 11.16 161 265530 50168 42305476
Aspergillus infection 45.23 11.16 21 265670 15816 42339828
Ventricular fibrillation 45.01 11.16 332 265359 29791 42325853
Cytomegalovirus infection reactivation 44.37 11.16 8 265683 11170 42344474
Appendicitis 44.25 11.16 249 265442 20364 42335280
Neutrophil count decreased 44.13 11.16 224 265467 63191 42292453
Erectile dysfunction 43.97 11.16 286 265405 24627 42331017
Synovitis 43.91 11.16 21 265670 15546 42340098
Haematotoxicity 43.31 11.16 8 265683 10977 42344667
Anosmia 43.15 11.16 98 265593 5078 42350566
Lactic acidosis 42.74 11.16 451 265240 44810 42310834
Asthma 42.30 11.16 222 265469 62092 42293552
Ischaemic cardiomyopathy 42.16 11.16 112 265579 6410 42349234
Cardiovascular disorder 41.99 11.16 180 265511 13185 42342459
Haemodialysis 41.83 11.16 150 265541 10110 42345534
Pathogen resistance 41.73 11.16 10 265681 11440 42344204
Neoplasm progression 41.60 11.16 73 265618 28927 42326717
Ventricular tachycardia 40.93 11.16 325 265366 29835 42325809
Accidental exposure to product 40.89 11.16 40 265651 20353 42335291
Altered state of consciousness 40.76 11.16 75 265616 29184 42326460
Hypogammaglobulinaemia 40.28 11.16 12 265679 11879 42343765
Illness 40.26 11.16 58 265633 24872 42330772
Gait inability 40.22 11.16 262 265429 22571 42333073
Bradycardia 39.99 11.16 752 264939 84732 42270912
Influenza 39.73 11.16 226 265465 61949 42293695
Blood urea increased 39.49 11.16 344 265347 32449 42323195
Serotonin syndrome 38.98 11.16 63 265628 25782 42329862
Myasthenia gravis 38.75 11.16 201 265490 15936 42339708
Muscle disorder 38.73 11.16 69 265622 2995 42352649
Social problem 38.64 11.16 43 265648 1193 42354451
Substance abuse 38.48 11.16 5 265686 8900 42346744
Tendonitis 38.11 11.16 142 265549 9752 42345892
Atrioventricular block complete 38.01 11.16 156 265535 11208 42344436
Suicide attempt 37.97 11.16 153 265538 45947 42309697
Muscle twitching 37.28 11.16 159 265532 11621 42344023
Hyponatraemia 36.84 11.16 860 264831 100602 42255042
Palpitations 36.79 11.16 481 265210 50316 42305328
Gastritis erosive 36.43 11.16 106 265585 6397 42349247
Oedema peripheral 36.09 11.16 1107 264584 134969 42220675
Platelet count decreased 36.04 11.16 627 265064 137954 42217690
Aplastic anaemia 36.03 11.16 16 265675 12368 42343276
Cytomegalovirus viraemia 36.02 11.16 10 265681 10367 42345277
Actinic keratosis 35.63 11.16 91 265600 5085 42350559
Ischaemic stroke 35.51 11.16 249 265442 21984 42333660
BK virus infection 35.50 11.16 6 265685 8778 42346866
Chronic obstructive pulmonary disease 35.18 11.16 571 265120 62543 42293101
Intercepted product preparation error 34.87 11.16 3 265688 7386 42348258
Immune reconstitution inflammatory syndrome 34.79 11.16 10 265681 10133 42345511
Joint swelling 34.51 11.16 265 265426 67757 42287887
Pain in extremity 34.48 11.16 1204 264487 149400 42206244
Multiple-drug resistance 34.48 11.16 3 265688 7319 42348325
Necrotising myositis 34.48 11.16 39 265652 1102 42354542
Impaired quality of life 34.42 11.16 23 265668 14154 42341490
White blood cell count decreased 33.91 11.16 484 265207 109912 42245732
Muscle necrosis 33.78 11.16 37 265654 1008 42354636
Naevus flammeus 33.56 11.16 19 265672 186 42355458
Brain scan abnormal 33.51 11.16 40 265651 1199 42354445
Mucormycosis 33.44 11.16 3 265688 7140 42348504
Injury 33.37 11.16 246 265445 22070 42333574
Bursitis 33.29 11.16 100 265591 6144 42349500
Diverticulum 33.12 11.16 113 265578 7428 42348216
Status epilepticus 33.07 11.16 29 265662 15549 42340095
Blood urea abnormal 32.87 11.16 38 265653 1100 42354544
Carotid artery stenosis 32.79 11.16 91 265600 5345 42350299
Neurotoxicity 32.62 11.16 61 265630 23590 42332054
Encephalopathy 32.29 11.16 140 265551 41193 42314451
Syringe issue 32.13 11.16 7 265684 8549 42347095
Hyperlipidaemia 32.07 11.16 237 265454 21279 42334365
Fear 31.66 11.16 144 265547 10821 42344823
Clostridium difficile infection 31.64 11.16 58 265633 22601 42333043
Myxoedema coma 31.60 11.16 20 265671 244 42355400
Poor venous access 31.51 11.16 4 265687 7248 42348396
Pancreatitis necrotising 31.44 11.16 70 265621 3579 42352065
Intestinal obstruction 30.87 11.16 78 265613 27080 42328564
Neuropathy peripheral 30.77 11.16 448 265243 101405 42254239
Atrial septal defect 30.72 11.16 6 265685 7913 42347731
Pelvic mass 30.71 11.16 19 265672 222 42355422
Atrioventricular block 30.60 11.16 130 265561 9485 42346159
Adrenal insufficiency 30.58 11.16 44 265647 18880 42336764
Therapeutic response decreased 30.37 11.16 123 265568 36889 42318755
Lymphopenia 30.28 11.16 55 265636 21508 42334136
Pancreatitis 30.21 11.16 407 265284 42861 42312783
Blood phosphorus increased 30.07 11.16 156 265535 12369 42343275
Bacteraemia 29.97 11.16 70 265621 24970 42330674
Cystitis haemorrhagic 29.63 11.16 5 265686 7324 42348320
Klebsiella infection 29.43 11.16 17 265674 11315 42344329
Lymphocyte count decreased 29.24 11.16 83 265608 27726 42327918
Urogenital haemorrhage 29.13 11.16 29 265662 705 42354939
Oedema mouth 29.04 11.16 39 265652 1319 42354325
Mucosal haemorrhage 28.91 11.16 45 265646 1745 42353899
Pain of skin 28.68 11.16 113 265578 7967 42347677
Incorrect dose administered 28.48 11.16 203 265488 52771 42302873
Product complaint 28.42 11.16 92 265599 5885 42349759
Acute coronary syndrome 28.31 11.16 174 265517 14691 42340953
Atrioventricular block first degree 28.28 11.16 97 265594 6394 42349250
Akathisia 28.12 11.16 15 265676 10436 42345208
Haematoma 27.76 11.16 282 265409 27741 42327903
Myoglobin blood increased 27.73 11.16 67 265624 3615 42352029
Acquired claw toe 27.69 11.16 8 265683 7 42355637
Glycosylated haemoglobin increased 27.66 11.16 156 265535 12768 42342876
Therapy interrupted 27.60 11.16 61 265630 22189 42333455
Lung disorder 27.58 11.16 180 265511 47743 42307901
Vascular device infection 27.47 11.16 3 265688 6107 42349537
Hypoxia 27.46 11.16 290 265401 69496 42286148
Forced expiratory volume decreased 27.15 11.16 7 265684 7623 42348021
Compartment syndrome 27.11 11.16 62 265629 3227 42352417
Muscle discomfort 26.96 11.16 17 265674 206 42355438
Cerebral artery thrombosis 26.91 11.16 36 265655 1213 42354431
Eczema 26.90 11.16 115 265576 33971 42321673
Faeces pale 26.66 11.16 41 265650 1573 42354071
Dialysis 26.53 11.16 146 265545 11840 42343804
Diplopia 26.52 11.16 217 265474 20099 42335545
Blood pressure fluctuation 26.36 11.16 83 265608 26825 42328819
Blood pressure systolic increased 26.19 11.16 88 265603 27880 42327764
Abdominal distension 26.02 11.16 608 265083 71127 42284517
Hyperthermia 25.98 11.16 24 265667 12550 42343094
Transient global amnesia 25.97 11.16 21 265670 385 42355259
Blood glucose fluctuation 25.92 11.16 75 265616 4512 42351132
Hiatus hernia 25.91 11.16 114 265577 8446 42347198
Overdose 25.86 11.16 481 265210 104783 42250861
Drug effective for unapproved indication 25.79 11.16 5 265686 6628 42349016
Actinic elastosis 25.72 11.16 11 265680 54 42355590
Pancreatic steatosis 25.72 11.16 16 265675 189 42355455
Psychiatric symptom 25.58 11.16 71 265620 4170 42351474
Abdominal pain upper 25.46 11.16 685 265006 81924 42273720
Seizure 25.41 11.16 565 265126 119996 42235648
Rash 25.36 11.16 1440 264251 275514 42080130
Myopathy toxic 25.29 11.16 27 265664 714 42354930
Hepatitis C 25.20 11.16 16 265675 10117 42345527
Alcohol poisoning 25.02 11.16 8 265683 7566 42348078
Emotional distress 24.98 11.16 179 265512 15914 42339730
Haematemesis 24.89 11.16 293 265398 29906 42325738
Alveolitis 24.87 11.16 43 265648 1822 42353822
Anhedonia 24.86 11.16 104 265587 7536 42348108
Gastritis 24.70 11.16 243 265448 23704 42331940
Full blood count abnormal 24.69 11.16 99 265592 29777 42325867
Respiratory syncytial virus infection 24.63 11.16 7 265684 7145 42348499
Accidental overdose 24.62 11.16 92 265599 28238 42327406
Neurological symptom 24.54 11.16 16 265675 9975 42345669
Dry mouth 24.19 11.16 366 265325 39513 42316131
Renal injury 24.18 11.16 145 265546 12135 42343509
Blood electrolytes abnormal 24.14 11.16 31 265660 1003 42354641
Ankylosing spondylitis 24.12 11.16 7 265684 7049 42348595
Renal cyst 24.07 11.16 125 265566 9914 42345730
Orthostatic hypotension 24.06 11.16 294 265397 30276 42325368
Miosis 24.05 11.16 29 265662 13417 42342227
Rebound effect 24.01 11.16 8 265683 7371 42348273
Wheezing 23.92 11.16 222 265469 54559 42301085
Stress 23.89 11.16 398 265293 43814 42311830
Nocturia 23.84 11.16 143 265548 11969 42343675
Asphyxia 23.84 11.16 11 265680 8315 42347329
Psoriatic arthropathy 23.77 11.16 78 265613 24889 42330755
Dilatation atrial 23.76 11.16 46 265645 2129 42353515
Duodenal ulcer 23.55 11.16 144 265547 12135 42343509
Subdural haematoma 23.48 11.16 234 265457 22904 42332740
Osteochondrosis 23.40 11.16 36 265655 1382 42354262
Cardio-respiratory arrest 23.34 11.16 243 265448 58393 42297251
Abdominal pain lower 23.32 11.16 142 265549 11950 42343694
Pallor 23.25 11.16 279 265412 28607 42327037
Device leakage 23.25 11.16 18 265673 10267 42345377
Mitochondrial myopathy 23.22 11.16 15 265676 190 42355454
Methaemoglobinaemia 23.21 11.16 4 265687 5770 42349874
Therapeutic product effect decreased 23.06 11.16 146 265545 39004 42316640
Weight increased 23.06 11.16 505 265186 107478 42248166
Contraindicated product prescribed 23.03 11.16 25 265666 674 42354970
Social avoidant behaviour 23.00 11.16 59 265632 3305 42352339
Blindness 22.91 11.16 191 265500 17787 42337857
Areflexia 22.91 11.16 63 265628 3680 42351964
Hemiparesis 22.90 11.16 186 265505 17190 42338454
Type 2 diabetes mellitus 22.89 11.16 195 265496 18276 42337368
Viral myositis 22.78 11.16 8 265683 20 42355624
Pneumonia aspiration 22.71 11.16 201 265490 49877 42305767
Bronchiectasis 22.68 11.16 49 265642 17970 42337674
Blood glucose decreased 22.56 11.16 159 265532 14060 42341584
Polymyositis 22.50 11.16 40 265651 1733 42353911
Ejaculation failure 22.50 11.16 27 265664 814 42354830
Product dose omission in error 22.47 11.16 12 265679 8342 42347302
Oesophageal obstruction 22.45 11.16 23 265668 579 42355065
Contusion 22.34 11.16 377 265314 41608 42314036
High density lipoprotein decreased 22.29 11.16 64 265627 3833 42351811
Acute myeloid leukaemia 22.26 11.16 68 265623 22188 42333456
Respiratory failure 22.26 11.16 618 265073 127514 42228130
Cerebral haemorrhage 22.25 11.16 354 265337 38612 42317032
Gout 22.16 11.16 270 265421 27785 42327859
Spinal osteoarthritis 22.12 11.16 110 265581 8576 42347068
Myoglobin urine present 22.07 11.16 13 265678 138 42355506
Spirometry abnormal 21.97 11.16 3 265688 5143 42350501
Cardiogenic shock 21.97 11.16 328 265363 35312 42320332
Personality change 21.96 11.16 82 265609 5637 42350007
Hypoalbuminaemia 21.76 11.16 40 265651 15570 42340074
Melaena 21.75 11.16 351 265340 38395 42317249
Brain oedema 21.74 11.16 43 265648 16284 42339360
Granuloma annulare 21.70 11.16 14 265677 177 42355467
Periarthritis calcarea 21.62 11.16 11 265680 85 42355559
Neuritis 21.58 11.16 6 265685 6214 42349430
Haemorrhage intracranial 21.57 11.16 182 265509 17010 42338634
Febrile bone marrow aplasia 21.55 11.16 19 265672 10162 42345482
Pulmonary alveolar haemorrhage 21.52 11.16 37 265654 14779 42340865
Analgesic therapy 21.38 11.16 89 265602 6435 42349209
Device issue 21.25 11.16 32 265659 13477 42342167
Swelling face 21.25 11.16 264 265427 27290 42328354
Poisoning 21.08 11.16 37 265654 14662 42340982
Arrhythmia 21.08 11.16 361 265330 39956 42315688
Lethargy 21.06 11.16 410 265281 46480 42309164
Spinal cord haemorrhage 21.01 11.16 17 265674 312 42355332
Mitochondrial myopathy acquired 20.99 11.16 7 265684 14 42355630
Completed suicide 20.92 11.16 450 265241 96015 42259629
Respiratory tract haemorrhage 20.80 11.16 34 265657 1375 42354269
Hypoglycaemic unconsciousness 20.69 11.16 25 265666 759 42354885
Myoglobin urine 20.67 11.16 7 265684 15 42355629
SARS-CoV-2 test positive 20.60 11.16 13 265678 8247 42347397
Loss of consciousness 20.54 11.16 736 264955 91618 42264026
Sickle cell anaemia with crisis 20.53 11.16 3 265688 4887 42350757
Aortic aneurysm 20.52 11.16 99 265592 7624 42348020
Multiple injuries 20.50 11.16 40 265651 1862 42353782
Blood loss anaemia 20.49 11.16 117 265574 9619 42346025
Hepatic encephalopathy 20.46 11.16 45 265646 16397 42339247
Pemphigoid 20.45 11.16 132 265559 11335 42344309
Genital ulcer syndrome 20.42 11.16 5 265686 0 42355644
Hypertensive crisis 20.41 11.16 121 265570 10085 42345559
Avoidant personality disorder 20.38 11.16 6 265685 6 42355638
Thrombotic thrombocytopenic purpura 20.35 11.16 61 265630 3743 42351901
Gingival pain 20.33 11.16 14 265677 8480 42347164
Hepatocellular carcinoma 20.29 11.16 13 265678 8181 42347463
Colitis ulcerative 20.23 11.16 89 265602 26086 42329558
Potentiating drug interaction 20.23 11.16 87 265604 6381 42349263
Hypopnoea 20.22 11.16 12 265679 7870 42347774
Nephropathy toxic 20.21 11.16 47 265644 16791 42338853
Central nervous system lesion 20.17 11.16 12 265679 7858 42347786
Ventricular hypertrophy 20.14 11.16 71 265620 4745 42350899
Sudden cardiac death 20.13 11.16 62 265629 3862 42351782
Anuria 20.11 11.16 132 265559 11400 42344244
Prostate cancer recurrent 20.02 11.16 29 265662 1054 42354590
Malignant spinal cord compression 19.94 11.16 12 265679 133 42355511
Diabetes mellitus inadequate control 19.88 11.16 164 265527 15226 42340418
Mitral valve incompetence 19.87 11.16 173 265518 16316 42339328
Nephrolithiasis 19.86 11.16 141 265550 36689 42318955
Blood pressure systolic abnormal 19.81 11.16 5 265686 5523 42350121
Pancreatitis chronic 19.65 11.16 44 265647 2258 42353386
Raynaud's phenomenon 19.45 11.16 15 265676 256 42355388
Disease recurrence 19.43 11.16 107 265584 29571 42326073
Peripheral vascular disorder 19.39 11.16 75 265616 5242 42350402
Angioplasty 19.37 11.16 28 265663 1016 42354628
Aphasia 19.12 11.16 232 265459 23851 42331793
Ischaemia 19.07 11.16 72 265619 4975 42350669
Lipase increased 19.07 11.16 122 265569 10444 42345200
Sinus bradycardia 19.04 11.16 158 265533 14695 42340949
Platelet count normal 19.02 11.16 7 265684 21 42355623
Aortic stenosis 19.01 11.16 106 265585 8639 42347005
Exposure to toxic agent 18.98 11.16 4 265687 5000 42350644
Pleurothotonus 18.94 11.16 30 265661 1181 42354463
Staphylococcal bacteraemia 18.83 11.16 25 265666 11096 42344548
Systemic candida 18.70 11.16 5 265686 5314 42350330
Systemic infection 18.64 11.16 73 265618 5132 42350512
Rash maculo-papular 18.60 11.16 147 265544 37356 42318288
Blood glucose abnormal 18.45 11.16 90 265601 6963 42348681
Gastrointestinal pain 18.39 11.16 65 265626 4350 42351294
Articular calcification 18.38 11.16 10 265681 90 42355554
Post procedural haemorrhage 18.37 11.16 110 265581 9202 42346442
Extremity necrosis 18.33 11.16 43 265648 2276 42353368
Vasculitic rash 18.28 11.16 27 265664 999 42354645
Pneumonia fungal 18.26 11.16 18 265673 9128 42346516
Eosinophilia 18.21 11.16 125 265566 32774 42322870
Cardiotoxicity 18.18 11.16 12 265679 7433 42348211
Anaphylactic shock 18.15 11.16 80 265611 23437 42332207
Disseminated intravascular coagulation 18.15 11.16 86 265605 24708 42330936
Total lung capacity abnormal 18.03 11.16 3 265688 4440 42351204
Ventricular extrasystoles 18.00 11.16 144 265547 13246 42342398
Occupational problem environmental 17.99 11.16 6 265685 12 42355632
Parosmia 17.98 11.16 13 265678 7678 42347966
Musculoskeletal pain 17.96 11.16 300 265391 33040 42322604
Presyncope 17.92 11.16 216 265475 22171 42333473
Cognitive disorder 17.87 11.16 306 265385 33866 42321778
Radiation inflammation 17.85 11.16 27 265664 1021 42354623
Feeding disorder 17.79 11.16 16 265675 8475 42347169
Ventricular septal defect 17.79 11.16 3 265688 4396 42351248
Aortic valve sclerosis 17.78 11.16 28 265663 1097 42354547
Pharyngeal oedema 17.75 11.16 80 265611 5988 42349656
Blood pressure diastolic abnormal 17.70 11.16 8 265683 6120 42349524
Hypotension 17.63 11.16 1849 263842 255782 42099862
Pneumatosis intestinalis 17.62 11.16 4 265687 4748 42350896
Tenderness 17.56 11.16 105 265586 8778 42346866
Rash papular 17.54 11.16 130 265561 11681 42343963
Hepatitis B 17.53 11.16 10 265681 6701 42348943
Hepatitis 17.52 11.16 253 265438 27047 42328597
Rhinorrhoea 17.50 11.16 121 265570 31673 42323971
Hyperammonaemia 17.49 11.16 14 265677 7852 42347792
Diabetes mellitus 17.32 11.16 494 265197 59593 42296051
Eye pruritus 17.17 11.16 126 265565 11286 42344358
Blood potassium increased 17.16 11.16 184 265507 18352 42337292
Upper motor neurone lesion 17.15 11.16 12 265679 175 42355469
Enterocolitis 17.14 11.16 22 265669 9907 42345737
Sleep attacks 17.12 11.16 11 265680 138 42355506
Serum ferritin abnormal 17.07 11.16 14 265677 262 42355382
Biliary cirrhosis 17.03 11.16 12 265679 177 42355467
Carcinogenicity 17.02 11.16 9 265682 76 42355568
Candida infection 16.99 11.16 73 265618 21537 42334107
Cytomegalovirus chorioretinitis 16.86 11.16 4 265687 4607 42351037
Low density lipoprotein increased 16.73 11.16 72 265619 5283 42350361
Feeling abnormal 16.73 11.16 561 265130 69225 42286419
Tongue oedema 16.70 11.16 52 265639 3258 42352386
Stent placement 16.69 11.16 72 265619 5288 42350356
Anal fistula 16.60 11.16 9 265682 6204 42349440
Pneumonitis 16.56 11.16 173 265518 41545 42314099
Contracted bladder 16.55 11.16 6 265685 17 42355627
Shock hypoglycaemic 16.54 11.16 9 265682 81 42355563
Musculoskeletal toxicity 16.53 11.16 11 265680 147 42355497
Fungal infection 16.52 11.16 65 265626 19657 42335987
Renal impairment 16.52 11.16 843 264848 109385 42246259
Coagulation time prolonged 16.52 11.16 31 265660 1401 42354243
Pneumothorax 16.46 11.16 83 265608 23460 42332184
Coordination abnormal 16.46 11.16 96 265595 7954 42347690
Barrett's oesophagus 16.41 11.16 16 265675 379 42355265
Bradyarrhythmia 16.35 11.16 45 265646 2630 42353014
Erythema 16.35 11.16 535 265156 108258 42247386
Malnutrition 16.34 11.16 42 265649 14500 42341144
Glycogen storage disease type IX 16.34 11.16 4 265687 0 42355644
Gynaecomastia 16.28 11.16 134 265557 12433 42343211
Faeces discoloured 16.27 11.16 170 265521 16844 42338800
Device related infection 16.26 11.16 68 265623 20211 42335433
Blood lactic acid 16.25 11.16 15 265676 331 42355313
Hypoglycaemic seizure 16.20 11.16 16 265675 385 42355259
Swollen tongue 16.19 11.16 203 265488 21028 42334616
Pulmonary tuberculosis 16.17 11.16 7 265684 5494 42350150
Therapy cessation 16.13 11.16 69 265622 20381 42335263
Abscess 16.13 11.16 41 265650 14207 42341437
Blood pressure diastolic increased 16.08 11.16 10 265681 6395 42349249
Exercise lack of 16.08 11.16 10 265681 118 42355526
Arthritis 16.06 11.16 176 265515 41889 42313755
Intermittent claudication 16.06 11.16 43 265648 2472 42353172
Sprue-like enteropathy 16.06 11.16 20 265671 627 42355017
Product storage error 16.01 11.16 28 265663 11112 42344532
Respiratory symptom 15.89 11.16 28 265663 11078 42344566
Coronary angioplasty 15.87 11.16 16 265675 395 42355249
Pulmonary fibrosis 15.84 11.16 244 265447 26437 42329207
Second primary malignancy 15.73 11.16 22 265669 9553 42346091
Parkinson's disease 15.73 11.16 29 265662 1293 42354351
Drug therapy 15.69 11.16 80 265611 6300 42349344
Infusion site pain 15.65 11.16 7 265684 5388 42350256
Lichen myxoedematosus 15.61 11.16 6 265685 21 42355623
Mydriasis 15.59 11.16 19 265672 8751 42346893
Periprosthetic fracture 15.50 11.16 12 265679 206 42355438
Immune-mediated enterocolitis 15.50 11.16 8 265683 5669 42349975
Carpal tunnel syndrome 15.44 11.16 72 265619 5467 42350177
Impatience 15.41 11.16 17 265674 467 42355177
Rhinovirus infection 15.40 11.16 11 265680 6537 42349107
Duodenitis 15.33 11.16 72 265619 5484 42350160
Carcinoma in situ 15.33 11.16 5 265686 9 42355635
Gingival recession 15.32 11.16 17 265674 470 42355174
Cytomegalovirus test positive 15.30 11.16 4 265687 4315 42351329
Angioimmunoblastic T-cell lymphoma 15.29 11.16 15 265676 358 42355286
Coronary artery bypass 15.28 11.16 65 265626 4745 42350899
Blood pressure orthostatic 15.19 11.16 8 265683 67 42355577
Lichen planus 15.18 11.16 28 265663 1249 42354395
Venoocclusive disease 15.12 11.16 3 265688 3912 42351732
Dystonia 15.11 11.16 36 265655 12754 42342890
Polycystic liver disease 15.09 11.16 9 265682 98 42355546
Labelled drug-drug interaction medication error 15.05 11.16 156 265535 15426 42340218
Nodule 15.03 11.16 35 265656 12499 42343145
Pneumonia bacterial 14.95 11.16 49 265642 15643 42340001
Acne 14.88 11.16 40 265651 13604 42342040
Depressed level of consciousness 14.82 11.16 210 265481 47760 42307884
Intentional self-injury 14.81 11.16 47 265644 15155 42340489
Arteriosclerotic gangrene 14.80 11.16 8 265683 71 42355573
Urinary incontinence 14.78 11.16 203 265488 21465 42334179
Electrocardiogram abnormal 14.69 11.16 111 265580 10034 42345610
Injected limb mobility decreased 14.67 11.16 5 265686 11 42355633
Blood creatine phosphokinase 14.63 11.16 9 265682 104 42355540
Sleep disorder therapy 14.61 11.16 83 265608 6811 42348833
Prothrombin time prolonged 14.51 11.16 105 265586 9364 42346280
Jaundice cholestatic 14.44 11.16 68 265623 5185 42350459
Embolic stroke 14.41 11.16 66 265625 4974 42350670
Adrenal cyst 14.40 11.16 11 265680 185 42355459
Portal fibrosis 14.34 11.16 14 265677 332 42355312
Diffuse large B-cell lymphoma 14.30 11.16 23 265668 9431 42346213
Gallbladder neoplasm 14.27 11.16 6 265685 28 42355616
Myocarditis 14.27 11.16 65 265626 18873 42336771
Electromyogram abnormal 14.22 11.16 7 265684 50 42355594
Cholecystitis chronic 14.22 11.16 23 265668 922 42354722
Skin toxicity 14.13 11.16 12 265679 6537 42349107
Social fear 14.12 11.16 4 265687 3 42355641
Interstitial lung disease 13.99 11.16 377 265314 78085 42277559
Injection site bruising 13.97 11.16 32 265659 11493 42344151
Tuberculosis 13.97 11.16 26 265665 10073 42345571
Erosive duodenitis 13.95 11.16 33 265658 1756 42353888
Iron binding capacity total increased 13.94 11.16 6 265685 30 42355614
Blood creatine phosphokinase MB increased 13.94 11.16 35 265656 1935 42353709
Bone erosion 13.93 11.16 5 265686 4398 42351246
Complications of transplanted kidney 13.93 11.16 8 265683 5342 42350302
Sinusitis 13.93 11.16 209 265482 47083 42308561
Epiglottitis 13.86 11.16 15 265676 403 42355241
Respiratory arrest 13.82 11.16 112 265579 28312 42327332
Splenic necrosis 13.80 11.16 9 265682 116 42355528
Hallucination 13.71 11.16 462 265229 57045 42298599
Memory impairment 13.68 11.16 410 265281 49812 42305832
Diabetic neuropathy 13.66 11.16 60 265631 4442 42351202
Drug specific antibody present 13.65 11.16 4 265687 4002 42351642
White blood cell count increased 13.64 11.16 373 265318 44714 42310930
Parainfluenzae virus infection 13.64 11.16 3 265688 3640 42352004
Immobile 13.60 11.16 44 265647 2814 42352830
PO2 increased 13.57 11.16 17 265674 536 42355108
COVID-19 pneumonia 13.56 11.16 79 265612 21534 42334110
Uveitis 13.56 11.16 23 265668 9235 42346409
Herpes zoster 13.55 11.16 166 265525 38711 42316933
Coronary artery thrombosis 13.52 11.16 38 265653 2248 42353396
Bradyphrenia 13.52 11.16 8 265683 5254 42350390
Osteonecrosis 13.47 11.16 52 265639 15813 42339831
Extrasystoles 13.46 11.16 57 265634 4152 42351492
Pseudoporphyria 13.45 11.16 16 265675 478 42355166
Basal ganglia haemorrhage 13.43 11.16 24 265667 1044 42354600
Activated partial thromboplastin time prolonged 13.42 11.16 155 265536 15748 42339896
Sepsis 13.40 11.16 1065 264626 198269 42157375
Device difficult to use 13.27 11.16 6 265685 4590 42351054
Concomitant disease progression 13.26 11.16 40 265651 2463 42353181
Vitamin B complex deficiency 13.24 11.16 16 265675 486 42355158
Progressive multifocal leukoencephalopathy 13.21 11.16 33 265658 11503 42344141
Tachypnoea 13.16 11.16 80 265611 21582 42334062
Blood bilirubin abnormal 13.14 11.16 21 265670 833 42354811
Blood pressure difference of extremities 13.12 11.16 4 265687 5 42355639
AST/ALT ratio abnormal 13.12 11.16 5 265686 17 42355627
Macroenzyme creatine kinase 13.12 11.16 5 265686 17 42355627
Rotator cuff syndrome 13.12 11.16 78 265613 6508 42349136
Cerebrovascular disorder 13.10 11.16 33 265658 1828 42353816
Cerebral arteriosclerosis 13.07 11.16 17 265674 557 42355087
C-reactive protein increased 13.06 11.16 299 265392 63261 42292383
Pneumonia klebsiella 13.05 11.16 5 265686 4224 42351420
Trichoglossia 13.03 11.16 14 265677 373 42355271
Intracardiac thrombus 13.01 11.16 39 265652 2393 42353251
Blood triglycerides increased 13.00 11.16 154 265537 15742 42339902
Aplasia 12.96 11.16 7 265684 4836 42350808
Overflow diarrhoea 12.96 11.16 7 265684 62 42355582
Upper gastrointestinal haemorrhage 12.96 11.16 263 265428 30036 42325608
Puncture site haematoma 12.95 11.16 10 265681 171 42355473
Acute myeloid leukaemia recurrent 12.93 11.16 3 265688 3509 42352135
Hyperhidrosis 12.91 11.16 689 265002 89823 42265821
Systemic lupus erythematosus 12.90 11.16 24 265667 9300 42346344
Osteoma 12.89 11.16 8 265683 94 42355550
Glycogen storage disease type V 12.79 11.16 6 265685 38 42355606
Maternal drugs affecting foetus 12.78 11.16 4 265687 3835 42351809
Subacute hepatic failure 12.75 11.16 8 265683 96 42355548
Escherichia infection 12.74 11.16 33 265658 11363 42344281
Gastrointestinal perforation 12.73 11.16 6 265685 4480 42351164
Psychological trauma 12.72 11.16 11 265680 222 42355422
Dental examination abnormal 12.71 11.16 4 265687 6 42355638
Pancreatic duct stenosis 12.71 11.16 10 265681 176 42355468
Nasal congestion 12.68 11.16 120 265571 29381 42326263
Drug intolerance 12.68 11.16 393 265298 80031 42275613
Viral infection 12.65 11.16 85 265606 22398 42333246
Colitis 12.64 11.16 209 265482 46363 42309281
Staphylococcal infection 12.64 11.16 162 265529 37481 42318163
Conjunctivitis allergic 12.55 11.16 11 265680 5900 42349744
Hepatic enzyme decreased 12.54 11.16 8 265683 99 42355545
Chronic fatigue syndrome 12.51 11.16 13 265678 333 42355311
Liver disorder 12.45 11.16 173 265518 39471 42316173
Volvulus 12.44 11.16 34 265657 1979 42353665
Oliguria 12.44 11.16 100 265591 9213 42346431
Rubber sensitivity 12.42 11.16 14 265677 394 42355250
Myotonia 12.41 11.16 6 265685 41 42355603
Cardiac disorder 12.40 11.16 396 265295 48536 42307108
Respiratory tract infection viral 12.36 11.16 3 265688 3403 42352241
Drug withdrawal syndrome 12.36 11.16 81 265610 21468 42334176
Cerebral ischaemia 12.34 11.16 80 265611 6879 42348765
Dermatitis atopic 12.33 11.16 38 265653 12366 42343278
Retinal vascular thrombosis 12.33 11.16 7 265684 69 42355575
Haemoglobin urine present 12.31 11.16 9 265682 141 42355503
Anaphylactic reaction 12.21 11.16 190 265501 42553 42313091
Acoustic neuroma 12.21 11.16 9 265682 143 42355501
Vertebral artery stenosis 12.21 11.16 9 265682 143 42355501
Fistula 12.20 11.16 19 265672 7893 42347751
Pulmonary pain 12.19 11.16 29 265662 1549 42354095
Lumbar radiculopathy 12.13 11.16 20 265671 815 42354829
Nerve conduction studies abnormal 12.06 11.16 6 265685 44 42355600
Hepatic failure 12.05 11.16 166 265525 37934 42317710
Precancerous skin lesion 12.05 11.16 17 265674 603 42355041
Muscle fatigue 12.05 11.16 31 265660 1740 42353904
Nightmare 12.02 11.16 221 265470 24791 42330853
Wrong technique in product usage process 12.02 11.16 190 265501 42445 42313199
Stress urinary incontinence 12.02 11.16 8 265683 107 42355537
Blood uric acid increased 12.01 11.16 149 265542 15398 42340246
Cardiac stress test abnormal 11.99 11.16 13 265678 350 42355294
Breast tenderness 11.99 11.16 20 265671 823 42354821
Otitis media 11.97 11.16 4 265687 3679 42351965
Cardiac failure 11.94 11.16 796 264895 106060 42249584
Glomerular filtration rate decreased 11.90 11.16 155 265536 16196 42339448
Cytomegalovirus colitis 11.81 11.16 5 265686 3976 42351668
Heliotrope rash 11.78 11.16 5 265686 24 42355620
Respiratory tract infection 11.78 11.16 106 265585 26216 42329428
Body temperature decreased 11.76 11.16 48 265643 14365 42341279
Immunodeficiency 11.73 11.16 17 265674 7273 42348371
Ureteric injury 11.73 11.16 6 265685 47 42355597
Disturbance in attention 11.72 11.16 256 265435 29610 42326034
International normalised ratio decreased 11.71 11.16 58 265633 4514 42351130
Butterfly rash 11.71 11.16 8 265683 112 42355532
Respiratory fatigue 11.71 11.16 8 265683 112 42355532
Hyperventilation 11.70 11.16 45 265646 3137 42352507
Frustration tolerance decreased 11.70 11.16 46 265645 3240 42352404
Crush syndrome 11.67 11.16 7 265684 77 42355567
Clostridium difficile colitis 11.63 11.16 81 265610 21171 42334473
Needle issue 11.60 11.16 23 265668 8704 42346940
Obsessive-compulsive disorder 11.58 11.16 15 265676 6728 42348916
Pseudomonal sepsis 11.58 11.16 6 265685 4243 42351401
Antipsychotic drug level decreased 11.56 11.16 24 265667 1169 42354475
Dermatitis acneiform 11.54 11.16 19 265672 7720 42347924
Hepatitis C virus test positive 11.53 11.16 12 265679 308 42355336
Dyspnoea exertional 11.48 11.16 401 265290 49747 42305897
Neonatal respiratory distress syndrome 11.40 11.16 7 265684 4506 42351138
Hemiplegia 11.29 11.16 86 265605 7793 42347851
Hepatitis cholestatic 11.28 11.16 102 265589 9722 42345922
Immature granulocyte count increased 11.23 11.16 11 265680 262 42355382
Injection site swelling 11.22 11.16 61 265630 16912 42338732
Mixed liver injury 11.21 11.16 7 265684 4467 42351177
Hypothyroidism 11.18 11.16 137 265554 31947 42323697

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 5140.11 10.05 4103 443569 116298 110025329
Myalgia 2280.13 10.05 3587 444085 218794 109922833
Drug interaction 1743.61 10.05 5203 442469 494980 109646647
Blood creatine phosphokinase increased 1614.68 10.05 1725 445947 71352 110070275
Acute kidney injury 1365.28 10.05 5633 442039 629797 109511830
Off label use 1195.50 10.05 2702 444970 1497483 108644144
Drug ineffective 1154.50 10.05 2810 444862 1517730 108623897
Myopathy 1117.74 10.05 876 446796 24084 110117543
Myocardial infarction 1087.72 10.05 2402 445270 189681 109951946
Maternal exposure during pregnancy 816.61 10.05 55 447617 254828 109886799
Systemic lupus erythematosus 802.93 10.05 59 447613 254279 109887348
Hand deformity 797.26 10.05 18 447654 218488 109923139
Synovitis 748.74 10.05 109 447563 273983 109867644
Pemphigus 728.45 10.05 33 447639 214537 109927090
Treatment failure 655.54 10.05 158 447514 277076 109864551
Coronary artery disease 652.66 10.05 1097 446575 70593 110071034
Glossodynia 625.92 10.05 80 447592 221924 109919703
Infusion related reaction 599.04 10.05 404 447268 380758 109760869
Folliculitis 592.22 10.05 19 447653 167634 109973993
Duodenal ulcer perforation 591.40 10.05 31 447641 177669 109963958
Syncope 579.21 10.05 1971 445701 200565 109941062
Helicobacter infection 568.82 10.05 44 447628 181833 109959794
Joint swelling 478.64 10.05 656 447016 442189 109699438
C-reactive protein abnormal 475.70 10.05 10 447662 129685 110011942
Fall 470.00 10.05 4102 443570 599380 109542247
Cerebrovascular accident 459.67 10.05 1696 445976 179588 109962039
Nasopharyngitis 459.42 10.05 552 447120 393809 109747818
Psoriatic arthropathy 449.88 10.05 120 447552 196641 109944986
Exposure during pregnancy 449.24 10.05 70 447602 167354 109974273
Rheumatoid arthritis 433.71 10.05 346 447326 299267 109842360
Product use in unapproved indication 410.00 10.05 740 446932 446637 109694990
Irritable bowel syndrome 409.44 10.05 83 447589 164132 109977495
Hyponatraemia 407.44 10.05 1854 445818 215799 109925828
Fibromyalgia 402.71 10.05 98 447574 170811 109970816
Sleep disorder due to general medical condition, insomnia type 392.06 10.05 7 447665 105636 110035991
Arthropathy 391.69 10.05 352 447320 287170 109854457
International normalised ratio increased 385.46 10.05 988 446684 85784 110055843
Wound 385.17 10.05 236 447436 234201 109907426
Muscle injury 382.04 10.05 57 447615 140750 110000877
Therapeutic product effect decreased 376.92 10.05 264 447408 244052 109897575
Stomatitis 376.37 10.05 324 447348 269918 109871709
Facet joint syndrome 356.95 10.05 7 447665 96821 110044806
Immune-mediated myositis 354.94 10.05 252 447420 5934 110135693
Transient ischaemic attack 352.56 10.05 792 446880 63190 110078437
Atrial fibrillation 351.62 10.05 1847 445825 227795 109913832
Gastrointestinal haemorrhage 346.32 10.05 1458 446214 164060 109977567
Myositis 344.85 10.05 521 447151 30595 110111032
Hypoglycaemia 342.38 10.05 1142 446530 114962 110026665
Rheumatoid factor positive 335.62 10.05 63 447609 131577 110010050
Dehydration 335.55 10.05 2107 445565 277404 109864223
Product prescribing error 335.41 10.05 681 446991 50650 110090977
Discomfort 332.51 10.05 231 447441 214476 109927151
Lactic acidosis 331.86 10.05 976 446696 91835 110049792
Drug intolerance 328.09 10.05 724 446948 405788 109735839
Ill-defined disorder 327.20 10.05 113 447559 156740 109984887
Tendon rupture 324.35 10.05 340 447332 13738 110127889
Cardiac failure congestive 322.06 10.05 1338 446334 149662 109991965
Pericarditis 320.85 10.05 250 447422 218864 109922763
Renal failure 320.26 10.05 1783 445889 224791 109916836
Product use issue 317.57 10.05 481 447191 311214 109830413
Febrile neutropenia 316.82 10.05 495 447177 316272 109825355
Acute myocardial infarction 311.07 10.05 893 446779 82884 110058743
Lip dry 310.67 10.05 25 447647 100058 110041569
Dizziness 309.49 10.05 4243 443429 693950 109447677
Breast cancer stage III 303.37 10.05 3 447669 79114 110062513
Hyperkalaemia 301.22 10.05 1218 446454 134578 110007049
Liver function test abnormal 294.83 10.05 774 446898 68176 110073451
Angioedema 289.65 10.05 968 446704 97532 110044095
Intentional product use issue 285.34 10.05 350 447322 247556 109894071
Joint range of motion decreased 282.84 10.05 72 447600 121760 110019867
Infection 280.93 10.05 659 447013 361541 109780086
Hypersensitivity 277.27 10.05 782 446890 403216 109738411
Sinusitis 270.49 10.05 492 447180 296196 109845431
Alopecia 264.60 10.05 687 446985 364066 109777561
Chronic lymphocytic leukaemia 259.70 10.05 206 447466 5762 110135865
Peripheral venous disease 258.36 10.05 22 447650 84095 110057532
Drug abuse 255.20 10.05 206 447466 177205 109964422
Hepatic enzyme increased 253.53 10.05 578 447094 320314 109821313
Muscular weakness 251.19 10.05 1795 445877 246673 109894954
Swelling 247.92 10.05 670 447002 350371 109791256
Gastrointestinal disorder 241.95 10.05 378 447294 241574 109900053
Contraindicated product administered 241.54 10.05 395 447277 247872 109893755
Grip strength decreased 240.77 10.05 23 447649 80151 110061476
Blister 236.27 10.05 346 447326 227030 109914597
Myelosuppression 234.47 10.05 48 447624 94292 110047335
Impaired healing 226.06 10.05 278 447394 196439 109945188
Wound infection 225.87 10.05 56 447616 96409 110045218
Live birth 225.35 10.05 14 447658 69470 110072157
Asthenia 224.76 10.05 3977 443695 685022 109456605
Deep vein thrombosis postoperative 223.93 10.05 3 447669 59288 110082339
Bradycardia 223.10 10.05 1229 446443 154288 109987339
Condition aggravated 222.44 10.05 1904 445768 732932 109408695
Wheezing 222.29 10.05 435 447237 254795 109886832
Bursitis 211.62 10.05 132 447540 129786 110011841
Product monitoring error 208.16 10.05 217 447455 8710 110132917
Lip swelling 203.72 10.05 556 447116 50111 110091516
Blood glucose increased 203.57 10.05 1067 446605 131429 110010198
Blood creatinine increased 201.76 10.05 1350 446322 181539 109960088
Labelled drug-drug interaction medication error 200.09 10.05 396 447276 28906 110112721
Type 2 diabetes mellitus 198.90 10.05 255 447417 176977 109964650
Chromaturia 197.14 10.05 394 447278 28966 110112661
Cardiospasm 196.15 10.05 162 447510 4805 110136822
Weight increased 196.09 10.05 952 446720 418692 109722935
Lung disorder 193.96 10.05 267 447405 179780 109961847
Carotid artery occlusion 192.33 10.05 215 447457 9350 110132277
Angina pectoris 190.98 10.05 621 447051 61674 110079953
Blepharospasm 190.89 10.05 7 447665 54844 110086783
Sleep terror 186.09 10.05 178 447494 6432 110135195
Drug ineffective for unapproved indication 185.53 10.05 92 447580 102746 110038881
Night sweats 184.78 10.05 162 447510 133821 110007806
Palmoplantar keratoderma 184.70 10.05 162 447510 5225 110136402
Therapeutic product effect incomplete 178.43 10.05 401 447271 223404 109918223
Lower respiratory tract infection 173.06 10.05 462 447210 242644 109898983
Asthma 172.68 10.05 483 447189 249808 109891819
Abdominal discomfort 172.33 10.05 914 446758 392944 109748683
Pruritus genital 171.17 10.05 169 447503 6353 110135274
Haematuria 171.04 10.05 728 446944 82277 110059350
Hypotension 170.33 10.05 3023 444649 520826 109620801
Dyspnoea 169.99 10.05 5763 441909 1101109 109040518
Lower limb fracture 168.33 10.05 48 447624 75300 110066327
Circulatory collapse 166.12 10.05 465 447207 42528 110099099
Autoimmune disorder 165.48 10.05 32 447640 65451 110076176
Subarachnoid haemorrhage 165.08 10.05 369 447303 29333 110112294
Myocardial ischaemia 164.87 10.05 346 447326 26338 110115289
Bone erosion 164.62 10.05 5 447667 46366 110095261
Muscle rupture 160.74 10.05 138 447534 4322 110137305
Anaemia 160.47 10.05 3107 444565 543979 109597648
Inflammation 160 10.05 339 447333 192899 109948728
Renal impairment 159.92 10.05 1307 446365 187138 109954489
Therapy non-responder 159.86 10.05 243 447429 157064 109984563
Atrial tachycardia 155.63 10.05 189 447483 8989 110132638
Liver injury 154.15 10.05 231 447441 150182 109991445
Appendicolith 154.14 10.05 236 447436 14019 110127608
Haematemesis 151.34 10.05 555 447117 58553 110083074
Tension headache 150.14 10.05 190 447482 9428 110132199
Pregnancy 149.82 10.05 16 447656 51051 110090576
Adjustment disorder with depressed mood 148.04 10.05 7 447665 43876 110097751
Urticaria 146.77 10.05 727 446945 318130 109823497
Cardiovascular disorder 146.34 10.05 300 447372 22460 110119167
Onychomadesis 142.84 10.05 11 447661 45652 110095975
Melaena 141.63 10.05 603 447069 68154 110073473
Muscle atrophy 141.31 10.05 218 447454 13036 110128591
Blood cholesterol increased 140.12 10.05 340 447332 184445 109957182
Chest pain 139.45 10.05 2219 445453 374156 109767471
Necrotising myositis 137.19 10.05 91 447581 1911 110139716
Cerebral haemorrhage 137.11 10.05 574 447098 64394 110077233
Angina unstable 137.09 10.05 242 447430 16190 110125437
Immunisation 136.64 10.05 109 447563 3074 110138553
Musculoskeletal stiffness 135.19 10.05 627 447045 279195 109862432
Coronary artery stenosis 133.85 10.05 217 447455 13541 110128086
Chronic obstructive pulmonary disease 132.76 10.05 826 446846 108332 110033295
X-ray abnormal 132.18 10.05 5 447667 38112 110103515
Ventricular tachycardia 130.94 10.05 473 447199 49536 110092091
Lethargy 130.48 10.05 734 446938 92842 110048785
Haematochezia 129.32 10.05 856 446816 114668 110026959
Nail disorder 127.41 10.05 38 447634 57897 110083730
Anosmia 127.21 10.05 201 447471 12271 110129356
Sciatica 125.86 10.05 113 447559 92286 110049341
Rash 125.40 10.05 2456 445216 818508 109323119
Drug resistance 123.93 10.05 37 447635 56337 110085290
Obesity 122.15 10.05 168 447504 113183 110028444
Muscle twitching 121.83 10.05 330 447342 29605 110112022
Coeliac disease 120.59 10.05 16 447656 43171 110098456
Sleep disorder due to a general medical condition 120.54 10.05 31 447641 52081 110089546
Diabetes mellitus inadequate control 116.96 10.05 324 447348 29451 110112176
Toxicity to various agents 116.22 10.05 1314 446358 479241 109662386
Osteoarthritis 115.41 10.05 367 447305 182256 109959371
Pyrexia 115.28 10.05 2763 444909 895502 109246125
Hip arthroplasty 115.00 10.05 41 447631 55772 110085855
Palpitations 114.10 10.05 1064 446608 158148 109983479
Pancreatitis acute 113.80 10.05 515 447157 59759 110081868
Coronary artery occlusion 112.36 10.05 217 447455 15555 110126072
Oedema peripheral 111.83 10.05 1911 445761 326749 109814878
Taste disorder 109.88 10.05 64 447608 65323 110076304
Prescribed overdose 109 10.05 116 447556 87465 110054162
Ischaemic stroke 108.64 10.05 391 447281 40872 110100755
Facial pain 108.00 10.05 210 447462 15129 110126498
Blindness 107.44 10.05 358 447314 36001 110105626
Upper gastrointestinal haemorrhage 106.80 10.05 444 447228 49652 110091975
Gait disturbance 106.68 10.05 1650 446022 276558 109865069
Cytokine release syndrome 105.69 10.05 78 447594 70228 110071399
Idiopathic pulmonary fibrosis 104.96 10.05 115 447557 4889 110136738
Neutropenia 104.61 10.05 990 446682 373630 109767997
Diplopia 103.59 10.05 389 447283 41505 110100122
Migraine 102.25 10.05 354 447318 171298 109970329
Haemorrhage intracranial 101.94 10.05 303 447369 28666 110112961
Self esteem decreased 101.68 10.05 60 447612 1017 110140610
Nightmare 101.25 10.05 367 447305 38496 110103131
General physical health deterioration 100.78 10.05 2342 445330 422953 109718674
Subdural haematoma 100.76 10.05 351 447321 36103 110105524
Haemodialysis 100.57 10.05 222 447450 17497 110124130
Hospitalisation 99.70 10.05 273 447399 142220 109999407
Cytomegalovirus infection 99.26 10.05 48 447624 54396 110087231
Mobility decreased 98.80 10.05 560 447112 236862 109904765
Malignant neoplasm progression 98.03 10.05 369 447303 174198 109967429
Balance disorder 97.00 10.05 805 446867 115755 110025872
Hypoaesthesia 96.67 10.05 810 446862 313413 109828214
Blood urea increased 95.97 10.05 459 447213 54498 110087129
Ventricular fibrillation 95.91 10.05 376 447296 40937 110100690
Inappropriate schedule of product administration 95.56 10.05 461 447211 203176 109938451
Device expulsion 95.07 10.05 8 447664 30883 110110744
Disturbance in attention 95.00 10.05 499 447173 61496 110080131
Pain 94.80 10.05 3045 444627 951910 109189717
Laryngitis 94.76 10.05 27 447645 42384 110099243
Presyncope 94.76 10.05 421 447251 48466 110093161
Loss of consciousness 94.46 10.05 1212 446460 195094 109946533
Acute coronary syndrome 94.27 10.05 255 447417 22857 110118770
Erectile dysfunction 93.71 10.05 222 447450 18334 110123293
C-reactive protein increased 93.40 10.05 509 447163 217410 109924217
Hyperlipidaemia 92.94 10.05 338 447334 35510 110106117
Appendicitis 92.93 10.05 290 447382 28174 110113453
Haematoma 92.60 10.05 475 447197 58001 110083626
Mitral valve incompetence 92.19 10.05 321 447351 33008 110108619
Injection site reaction 92.02 10.05 136 447536 88934 110052693
Injury 91.13 10.05 388 447284 176877 109964750
Hyperhidrosis 90.80 10.05 1158 446514 186140 109955487
Hallucination 90.08 10.05 711 446961 100721 110040906
Myoglobinuria 89.47 10.05 58 447614 1170 110140457
Muscle necrosis 89.04 10.05 67 447605 1730 110139897
Breast cancer stage II 87.33 10.05 6 447666 27369 110114258
Ischaemic cardiomyopathy 87.14 10.05 133 447539 7878 110133749
Sinus bradycardia 85.97 10.05 289 447383 29194 110112433
Therapy partial responder 85.81 10.05 22 447650 37039 110104588
Cardiogenic shock 85.45 10.05 458 447214 56880 110084747
Abnormal dreams 85.19 10.05 171 447501 12609 110129018
Arteriosclerosis coronary artery 84.87 10.05 259 447413 24859 110116768
Road traffic accident 83.47 10.05 195 447477 107203 110034424
Amnesia 82.96 10.05 719 446953 104689 110036938
Injection site pain 82.77 10.05 404 447268 177518 109964109
Finger deformity 81.88 10.05 17 447655 33075 110108552
Arthralgia 81.41 10.05 2469 445203 777163 109364464
Liver disorder 80.95 10.05 299 447373 141944 109999683
Hyperglycaemia 80.88 10.05 606 447066 84484 110057143
Amyotrophic lateral sclerosis 80.08 10.05 67 447605 2024 110139603
Drug hypersensitivity 79.06 10.05 1327 446345 452763 109688864
Abortion spontaneous 78.14 10.05 21 447651 34261 110107366
Back injury 76.01 10.05 49 447623 47350 110094277
Ear infection 75.95 10.05 85 447587 62647 110078980
Pain of skin 75.77 10.05 215 447457 19814 110121813
Blood phosphorus increased 75.59 10.05 189 447483 16151 110125476
Alanine aminotransferase increased 75.49 10.05 1103 446569 182670 109958957
Myasthenia gravis 74.74 10.05 224 447448 21287 110120340
Blood loss anaemia 74.65 10.05 200 447472 17825 110123802
Subdural haemorrhage 74.35 10.05 111 447561 6447 110135180
Knee arthroplasty 74.34 10.05 92 447580 64856 110076771
Polymyositis 73.96 10.05 83 447589 3625 110138002
Liver function test increased 73.55 10.05 155 447517 88393 110053234
Urosepsis 73.51 10.05 282 447390 30393 110111234
Myoglobin blood increased 73.14 10.05 88 447584 4144 110137483
COVID-19 71.66 10.05 640 447032 244420 109897207
Atrioventricular block 71.65 10.05 189 447483 16688 110124939
Oedema 71.19 10.05 527 447145 209449 109932178
Peripheral swelling 70.88 10.05 1179 446493 402855 109738772
Illness 70.66 10.05 141 447531 82030 110059597
Arrhythmia 68.11 10.05 499 447173 69076 110072551
Pancreatitis necrotising 68.01 10.05 97 447575 5404 110136223
Confusional state 67.48 10.05 2424 445248 466256 109675371
Hypertensive crisis 66.77 10.05 234 447438 24138 110117489
Gout 66.47 10.05 309 447363 36257 110105370
Diverticulum 66.05 10.05 174 447498 15352 110126275
Blood pressure inadequately controlled 65.73 10.05 114 447558 7519 110134108
Haemophagocytic lymphohistiocytosis 65.33 10.05 23 447649 31536 110110091
Bronchopulmonary aspergillosis 64.92 10.05 20 447652 29843 110111784
Cardiac failure 64.86 10.05 1094 446578 186532 109955095
Myopathy toxic 64.76 10.05 49 447623 1276 110140351
Quality of life decreased 64.62 10.05 163 447509 14006 110127621
Arthritis 64.56 10.05 405 447267 167181 109974446
Anuria 64.37 10.05 231 447441 24110 110117517
Renal injury 64.21 10.05 194 447478 18519 110123108
Fear 63.82 10.05 223 447449 22970 110118657
High density lipoprotein decreased 63.52 10.05 96 447576 5637 110135990
Graft versus host disease 63.43 10.05 3 447669 18803 110122824
Carotid artery stenosis 63.01 10.05 125 447547 9138 110132489
Exostosis 61.63 10.05 57 447615 45899 110095728
Social problem 61.55 10.05 55 447617 1819 110139808
Cognitive disorder 61.25 10.05 582 447090 86929 110054698
Pancreatic steatosis 60.88 10.05 54 447618 1768 110139859
Epilepsy 60.79 10.05 205 447467 100004 110041623
Therapeutic response shortened 60.49 10.05 22 447650 29561 110112066
Duodenal ulcer 60.22 10.05 195 447477 19319 110122308
Immunodeficiency 59.80 10.05 42 447630 38796 110102831
Diabetic ketoacidosis 59.34 10.05 331 447341 41727 110099900
Analgesic therapy 59.12 10.05 106 447566 7178 110134449
No adverse event 59.05 10.05 132 447540 73707 110067920
Naevus flammeus 58.93 10.05 19 447653 60 110141567
Atrioventricular block complete 58.68 10.05 197 447475 19885 110121742
Disease progression 58.62 10.05 668 447004 243366 109898261
Therapeutic drug monitoring analysis not performed 58.19 10.05 54 447618 1877 110139750
Pallor 58.17 10.05 410 447262 56057 110085570
Actinic keratosis 58.13 10.05 103 447569 6910 110134717
Feeling abnormal 57.90 10.05 1041 446631 179670 109961957
Drug dependence 57.10 10.05 71 447601 49949 110091678
Loss of personal independence in daily activities 56.53 10.05 365 447307 149655 109991972
Tinnitus 56.31 10.05 429 447243 60111 110081516
Sleep disorder 56.23 10.05 523 447149 198121 109943506
Poor venous access 55.93 10.05 15 447657 24507 110117120
Jaundice 55.79 10.05 421 447251 58815 110082812
Ear pain 55.24 10.05 81 447591 53145 110088482
Cardiac disorder 55.23 10.05 511 447161 75769 110065858
Onychomycosis 55.05 10.05 45 447627 38486 110103141
Diabetes mellitus 54.48 10.05 629 447043 98752 110042875
Osteoporosis 54.44 10.05 176 447496 86976 110054651
Swollen tongue 54.07 10.05 424 447248 59938 110081689
Faeces discoloured 53.91 10.05 276 447396 33672 110107955
Systemic infection 53.46 10.05 121 447551 9698 110131929
Mucosal inflammation 53.45 10.05 204 447468 95937 110045690
Haemorrhagic stroke 53.12 10.05 149 447523 13640 110127987
Agranulocytosis 53.08 10.05 106 447566 61654 110079973
Lupus-like syndrome 53.06 10.05 52 447620 40740 110100887
Dialysis 52.57 10.05 187 447485 19432 110122195
Transplant rejection 52.43 10.05 17 447655 24550 110117077
Lower gastrointestinal haemorrhage 51.96 10.05 179 447493 18307 110123320
Ventricular extrasystoles 51.69 10.05 205 447467 22436 110119191
Sedation complication 51.68 10.05 9 447663 19846 110121781
Peripheral vascular disorder 51.58 10.05 110 447562 8466 110133161
Haemoglobin decreased 51.44 10.05 1345 446327 247382 109894245
Sedation 51.40 10.05 130 447542 69553 110072074
Orthostatic hypotension 51.13 10.05 450 447222 65799 110075828
Hypokalaemia 50.91 10.05 1029 446643 181419 109960208
Hypomagnesaemia 50.78 10.05 418 447254 59952 110081675
Rash papular 50.56 10.05 234 447438 27405 110114222
Faeces pale 50.32 10.05 65 447607 3292 110138335
Aortic stenosis 50.20 10.05 141 447531 12918 110128709
Mitochondrial myopathy 50.10 10.05 28 447644 426 110141201
Arteriosclerosis 50.06 10.05 216 447456 24551 110117076
Abnormal loss of weight 49.95 10.05 121 447551 10136 110131491
Orthostatic intolerance 49.84 10.05 52 447620 2089 110139538
Blood potassium increased 49.82 10.05 266 447406 32983 110108644
Foetal death 49.81 10.05 4 447668 16041 110125586
Product dose omission issue 49.75 10.05 960 446712 320822 109820805
Adverse reaction 49.67 10.05 29 447643 29565 110112062
Venoocclusive liver disease 49.50 10.05 3 447669 15204 110126423
Atrioventricular block first degree 49.30 10.05 148 447524 14077 110127550
Glomerular filtration rate decreased 49.22 10.05 240 447432 28716 110112911
Foot deformity 49.12 10.05 75 447597 48405 110093222
Blood glucose decreased 49.12 10.05 243 447429 29245 110112382
Head injury 48.88 10.05 320 447352 42697 110098930
Premature delivery 48.66 10.05 32 447640 30600 110111027
Infusion site reaction 48.31 10.05 7 447665 17675 110123952
Electrocardiogram abnormal 48.16 10.05 176 447496 18533 110123094
Potentiating drug interaction 48.03 10.05 129 447543 11514 110130113
Drug therapy 47.93 10.05 97 447575 7194 110134433
Urogenital haemorrhage 47.89 10.05 36 447636 928 110140699
Rhinorrhoea 47.80 10.05 233 447439 102433 110039194
Aspergillus infection 47.59 10.05 22 447650 25594 110116033
Gastritis erosive 47.54 10.05 131 447541 11869 110129758
Unresponsive to stimuli 47.54 10.05 430 447242 63360 110078267
Drug use disorder 47.46 10.05 8 447664 18066 110123561
Hiatus hernia 47.06 10.05 229 447443 27377 110114250
Hepatic cyst 47.01 10.05 100 447572 7683 110133944
Peripheral arterial occlusive disease 46.83 10.05 111 447561 9169 110132458
Quadriparesis 46.82 10.05 75 447597 4632 110136995
Poisoning deliberate 46.82 10.05 24 447648 26307 110115320
Activated partial thromboplastin time prolonged 46.70 10.05 197 447475 22171 110119456
Blood glucose fluctuation 46.60 10.05 99 447573 7599 110134028
Pneumocystis jirovecii pneumonia 46.37 10.05 63 447609 42672 110098955
Haematotoxicity 46.04 10.05 14 447658 21068 110120559
Oedema mouth 45.98 10.05 60 447612 3070 110138557
Aortic arteriosclerosis 45.94 10.05 122 447550 10816 110130811
Adverse event 45.58 10.05 256 447416 108553 110033074
Therapeutic response decreased 45.51 10.05 218 447454 96281 110045346
Adrenal insufficiency 45.48 10.05 63 447609 42327 110099300
Oxygen saturation decreased 45.43 10.05 411 447261 156571 109985056
Influenza 45.41 10.05 451 447221 168650 109972977
Intermittent claudication 45.38 10.05 65 447607 3636 110137991
Cutaneous T-cell dyscrasia 44.82 10.05 15 447657 55 110141572
Hypercholesterolaemia 44.74 10.05 202 447470 90635 110050992
Pemphigoid 44.64 10.05 178 447494 19529 110122098
Accidental exposure to product 44.56 10.05 84 447588 49924 110091703
Red blood cell sedimentation rate increased 44.27 10.05 165 447507 78137 110063490
Therapy interrupted 44.12 10.05 84 447588 49738 110091889
Glycosylated haemoglobin increased 43.97 10.05 201 447471 23418 110118209
Dermatomyositis 43.55 10.05 70 447602 4336 110137291
Blood pressure fluctuation 43.41 10.05 156 447516 74668 110066959
Dilatation atrial 43.39 10.05 65 447607 3787 110137840
Vasculitis 43.31 10.05 271 447401 35602 110106025
Exercise tolerance decreased 43.20 10.05 127 447545 11940 110129687
International normalised ratio decreased 43.19 10.05 100 447572 8136 110133491
Femoral hernia incarcerated 43.17 10.05 41 447631 1468 110140159
Gastritis 43.14 10.05 368 447304 53331 110088296
Gynaecomastia 43.10 10.05 109 447563 9381 110132246
Muscle disorder 42.96 10.05 88 447584 6584 110135043
Dysarthria 42.84 10.05 525 447147 83596 110058031
Coronary artery thrombosis 42.78 10.05 59 447613 3185 110138442
Hypophagia 42.46 10.05 361 447311 52265 110089362
Immune effector cell-associated neurotoxicity syndrome 42.43 10.05 5 447667 14777 110126850
Blood uric acid increased 42.17 10.05 186 447486 21343 110120284
Device difficult to use 41.96 10.05 12 447660 18793 110122834
Musculoskeletal toxicity 41.95 10.05 20 447652 214 110141413
Multiple-drug resistance 41.93 10.05 3 447669 13232 110128395
Chronic kidney disease 41.87 10.05 483 447189 75808 110065819
Brain scan abnormal 41.77 10.05 41 447631 1530 110140097
Respiratory tract haemorrhage 41.75 10.05 46 447626 1968 110139659
Epstein-Barr virus infection 41.73 10.05 12 447660 18726 110122901
Aspartate aminotransferase increased 41.67 10.05 893 446779 159043 109982584
Tumour lysis syndrome 41.54 10.05 38 447634 30763 110110864
Walking aid user 41.48 10.05 25 447647 25050 110116577
Neoplasm progression 41.36 10.05 129 447543 64466 110077161
Underdose 41.35 10.05 126 447546 63428 110078199
Pneumonia 41.21 10.05 3024 444648 873690 109267937
Post procedural haemorrhage 40.84 10.05 147 447525 15365 110126262
Multiple injuries 40.73 10.05 61 447611 3553 110138074
Nocturia 40.55 10.05 156 447516 16834 110124793
Thrombotic microangiopathy 40.47 10.05 35 447637 29114 110112513
Anhedonia 40.44 10.05 146 447526 15282 110126345
Speech disorder 40.40 10.05 404 447268 61165 110080462
Gouty tophus 40.29 10.05 25 447647 466 110141161
Neutrophil count decreased 40.28 10.05 305 447367 120636 110020991
Cytomegalovirus viraemia 40.26 10.05 11 447661 17753 110123874
Glycogen storage disease type V 40.13 10.05 12 447660 27 110141600
Pathogen resistance 39.95 10.05 11 447661 17661 110123966
Social avoidant behaviour 39.63 10.05 75 447597 5294 110136333
Product dose omission in error 39.52 10.05 23 447649 23489 110118138
Pain in extremity 39.40 10.05 2378 445294 484740 109656887
Epistaxis 39.30 10.05 744 446928 129628 110011999
Urinary retention 39.07 10.05 443 447229 69240 110072387
Musculoskeletal pain 39.01 10.05 514 447158 182509 109959118
Caesarean section 38.86 10.05 5 447667 13812 110127815
Ankylosing spondylitis 38.67 10.05 8 447664 15604 110126023
Cytomegalovirus infection reactivation 38.57 10.05 13 447659 18320 110123307
Abdominal pain lower 38.57 10.05 271 447401 37012 110104615
Contraindicated product prescribed 38.52 10.05 47 447625 2246 110139381
Sleep disorder therapy 38.40 10.05 90 447582 7381 110134246
Pancreatitis 38.23 10.05 561 447111 92972 110048655
Labile hypertension 38.11 10.05 26 447646 573 110141054
Hemiparesis 38.01 10.05 306 447366 43597 110098030
Emotional distress 37.97 10.05 311 447361 44536 110097091
Transient global amnesia 37.94 10.05 33 447639 1052 110140575
Cerebral artery thrombosis 37.91 10.05 40 447632 1628 110139999
Lymphatic fistula 37.87 10.05 38 447634 1457 110140170
Tachyarrhythmia 37.63 10.05 95 447577 8166 110133461
Seroma 37.61 10.05 56 447616 3245 110138382
Haemarthrosis 37.35 10.05 88 447584 7241 110134386
Food allergy 37.27 10.05 17 447655 19931 110121696
Injection site erythema 37.09 10.05 226 447446 93950 110047677
Sinus node dysfunction 37.08 10.05 100 447572 8947 110132680
Autoimmune hepatitis 37.04 10.05 138 447534 14666 110126961
Mucosal haemorrhage 36.97 10.05 53 447619 2967 110138660
Compartment syndrome 36.93 10.05 77 447595 5833 110135794
Muscle spasms 36.93 10.05 1426 446246 276731 109864896
Bone marrow failure 36.70 10.05 116 447556 57732 110083895
Swelling face 36.67 10.05 551 447121 91770 110049857
Decorticate posture 36.27 10.05 21 447651 343 110141284
Blood pressure systolic increased 36.00 10.05 193 447479 82798 110058829
Urinary incontinence 35.94 10.05 327 447345 48260 110093367
Psychiatric symptom 35.93 10.05 100 447572 9113 110132514
Hallucination, visual 35.91 10.05 279 447393 39326 110102301
Urinary tract infection 35.90 10.05 1640 446032 324642 109816985
Intraventricular haemorrhage 35.89 10.05 73 447599 5434 110136193
Cerebral ischaemia 35.60 10.05 119 447553 11985 110129642
Drug reaction with eosinophilia and systemic symptoms 35.56 10.05 191 447481 81904 110059723
Infusion site pain 35.54 10.05 13 447659 17406 110124221
Disability 35.45 10.05 42 447630 30181 110111446
International normalised ratio abnormal 35.35 10.05 79 447593 6278 110135349
Adverse drug reaction 35.25 10.05 266 447406 105293 110036334
Temperature regulation disorder 35.22 10.05 5 447667 12821 110128806
Cytopenia 35.16 10.05 42 447630 30074 110111553
Low density lipoprotein increased 35.12 10.05 109 447563 10557 110131070
Disorientation 35.10 10.05 439 447233 70232 110071395
Cold sweat 34.90 10.05 179 447493 21852 110119775
Suicide attempt 34.79 10.05 260 447412 103134 110038493
Groin pain 34.67 10.05 139 447533 15289 110126338
Injection site bruising 34.53 10.05 100 447572 51163 110090464
Blood pressure systolic abnormal 34.30 10.05 30 447642 24820 110116807
Tremor 33.89 10.05 1065 446607 201167 109940460
Dyspnoea exertional 33.87 10.05 601 447071 103459 110038168
Dysuria 33.81 10.05 383 447289 59848 110081779
Blood urea abnormal 33.75 10.05 40 447632 1854 110139773
Dry mouth 33.55 10.05 588 447084 199360 109942267
Collagen disorder 33.49 10.05 19 447653 298 110141329
Intentional overdose 33.27 10.05 359 447313 132142 110009485
Respiratory disorder 33.23 10.05 162 447510 71220 110070407
Muscle spasticity 33.19 10.05 59 447613 35856 110105771
Eye pruritus 33.18 10.05 237 447435 32538 110109089
Metabolic acidosis 33.15 10.05 578 447094 99166 110042461
Duodenitis 33.13 10.05 97 447575 9099 110132528
Blood creatine phosphokinase MB increased 32.72 10.05 49 447623 2854 110138773
Constipation 32.65 10.05 1766 445906 356020 109785607
Lichenoid keratosis 32.48 10.05 76 447596 6226 110135401
Angioplasty 32.46 10.05 40 447632 1931 110139696
Pseudomonas infection 32.35 10.05 39 447633 27814 110113813
Sprue-like enteropathy 32.19 10.05 37 447635 1659 110139968
Pancytopenia 32.18 10.05 626 447046 208987 109932640
Lipoprotein (a) decreased 32.12 10.05 11 447661 44 110141583
Ventricular hypertrophy 32.08 10.05 81 447591 6964 110134663
Dermatitis exfoliative 32 10.05 110 447562 11237 110130390
BK virus infection 31.88 10.05 7 447665 13099 110128528
Tricuspid valve incompetence 31.78 10.05 185 447487 23688 110117939
Oesophagitis 31.65 10.05 212 447460 28503 110113124
Electrolyte imbalance 31.47 10.05 257 447415 36771 110104856
Upper respiratory tract infection 31.32 10.05 360 447312 130968 110010659
Extrasystoles 31.18 10.05 89 447583 8229 110133398
Hepatic cirrhosis 31.18 10.05 154 447518 67472 110074155
Blood glucose abnormal 31.16 10.05 119 447553 12797 110128830
Prostate cancer recurrent 31.13 10.05 28 447644 934 110140693
Ischaemia 31.01 10.05 94 447578 8989 110132638
Atrial flutter 31.00 10.05 186 447486 24076 110117551
Frequent bowel movements 30.98 10.05 166 447506 71224 110070403
Hyperphosphataemia 30.94 10.05 140 447532 16241 110125386
Spinal cord haemorrhage 30.86 10.05 23 447649 585 110141042
Prothrombin time prolonged 30.74 10.05 145 447527 17116 110124511
Facial paresis 30.72 10.05 73 447599 6040 110135587
Aortic aneurysm 30.59 10.05 99 447573 9805 110131822
Blood alkaline phosphatase increased 30.40 10.05 429 447243 70506 110071121
Actinic elastosis 30.00 10.05 11 447661 56 110141571
Diverticulum intestinal 29.96 10.05 110 447562 11609 110130018
Granuloma annulare 29.89 10.05 26 447646 829 110140798
Erythema dyschromicum perstans 29.79 10.05 12 447660 82 110141545
Basal cell carcinoma 29.68 10.05 297 447375 44973 110096654
Aphasia 29.52 10.05 367 447305 58630 110082997
Carotid arteriosclerosis 29.44 10.05 48 447624 3009 110138618
Cerebral infarction 29.26 10.05 330 447342 51508 110090119
Acne 29.26 10.05 57 447615 33463 110108164
Antacid therapy 29.21 10.05 67 447605 5417 110136210
Myocardial depression 29.17 10.05 24 447648 708 110140919
Headache 29.16 10.05 3127 444545 879250 109262377
Anticoagulant therapy 29.11 10.05 66 447606 5295 110136332
Lipase increased 29.09 10.05 151 447521 18521 110123106
Ubiquinone decreased 29.03 10.05 9 447663 24 110141603
Areflexia 28.94 10.05 76 447596 6693 110134934
Gastric ulcer 28.93 10.05 267 447405 39560 110102067
Gamma-glutamyltransferase increased 28.40 10.05 376 447296 60933 110080694
Joint destruction 28.39 10.05 5 447667 10938 110130689
Lacunar infarction 28.34 10.05 72 447600 6214 110135413
Bacteraemia 28.32 10.05 83 447589 42307 110099320
Retinal artery thrombosis 28.29 10.05 12 447660 95 110141532
Blood pressure diastolic abnormal 28.07 10.05 38 447634 25777 110115850
Body temperature decreased 27.95 10.05 68 447604 36867 110104760
Spontaneous haematoma 27.89 10.05 37 447635 1924 110139703
Blood sodium decreased 27.89 10.05 257 447415 38062 110103565
Aortic valve stenosis 27.87 10.05 72 447600 6278 110135349
Rectal haemorrhage 27.73 10.05 658 447014 119175 110022452
Substance abuse 27.72 10.05 8 447664 12455 110129172
Wound infection pseudomonas 27.61 10.05 41 447631 2370 110139257
Cerebellar ataxia 27.57 10.05 38 447634 2050 110139577
Thrombotic thrombocytopenic purpura 27.55 10.05 77 447595 7034 110134593
Immobile 27.51 10.05 81 447591 7621 110134006
Eosinophilic granulomatosis with polyangiitis 27.47 10.05 5 447667 10681 110130946
Ejaculation failure 27.47 10.05 18 447654 370 110141257
Device issue 27.40 10.05 62 447610 34473 110107154
Mucormycosis 27.26 10.05 5 447667 10623 110131004
Exposure to toxic agent 27.26 10.05 9 447663 12849 110128778
Spinal osteoarthritis 27.26 10.05 157 447515 20026 110121601
Radiation inflammation 27.21 10.05 27 447645 1021 110140606
Aortic valve sclerosis 27.21 10.05 36 447636 1867 110139760
Septic shock 27.15 10.05 461 447211 157067 109984560
Product substitution issue 27.09 10.05 173 447499 22888 110118739
Injection site pruritus 27.07 10.05 111 447561 51147 110090480
Coronary arterial stent insertion 26.92 10.05 68 447604 5847 110135780
Obstructive airways disorder 26.91 10.05 96 447576 46053 110095574
Dysphagia 26.82 10.05 813 446859 152787 109988840
Vascular stent stenosis 26.76 10.05 32 447640 1497 110140130
Arterial haemorrhage 26.54 10.05 52 447620 3767 110137860
Radiculopathy 26.50 10.05 151 447521 19185 110122442
Sensory disturbance 26.50 10.05 140 447532 17289 110124338
SARS-CoV-2 test positive 26.49 10.05 18 447654 16917 110124710
Muscle discomfort 26.48 10.05 19 447653 455 110141172
Ascites 26.40 10.05 525 447147 92283 110049344
Faecaloma 26.38 10.05 125 447547 14783 110126844
Cerebrovascular disorder 26.36 10.05 51 447621 3660 110137967
Cardiomegaly 26.29 10.05 205 447467 28925 110112702
Device use error 26.27 10.05 3 447669 9086 110132541
Multiple organ dysfunction syndrome 26.23 10.05 802 446870 150908 109990719
Cardiac arrest 26.18 10.05 1009 446663 195744 109945883
Overlap syndrome 26.16 10.05 3 447669 9056 110132571
Drug dose omission by device 26.15 10.05 13 447659 14503 110127124
Product complaint 26.08 10.05 119 447553 13853 110127774
Coronary artery bypass 25.99 10.05 68 447604 5974 110135653
Blood triglycerides increased 25.98 10.05 176 447496 23750 110117877
Sudden cardiac death 25.86 10.05 65 447607 5572 110136055
Portal fibrosis 25.79 10.05 22 447650 683 110140944
Bundle branch block left 25.74 10.05 112 447560 12776 110128851
Femoral neck fracture 25.70 10.05 110 447562 12457 110129170
Colitis microscopic 25.69 10.05 115 447557 13279 110128348
Haematocrit decreased 25.63 10.05 393 447279 65724 110075903
Blood pressure diastolic increased 25.61 10.05 23 447649 18784 110122843
Pulmonary embolism 25.56 10.05 1087 446585 213387 109928240
Hyperthermia 25.55 10.05 29 447643 21243 110120384
Periarthritis calcarea 25.52 10.05 11 447661 91 110141536
Anaemia vitamin B12 deficiency 25.39 10.05 28 447644 1199 110140428
Diabetic neuropathy 25.38 10.05 74 447598 6925 110134702
Hypothermia 25.37 10.05 188 447484 26114 110115513
Complication of device insertion 25.34 10.05 3 447669 8835 110132792
Nail ridging 25.25 10.05 20 447652 558 110141069
Mitochondrial myopathy acquired 25.18 10.05 9 447663 42 110141585
Diverticulum intestinal haemorrhagic 25.16 10.05 58 447614 4705 110136922
Myoglobin urine 25.12 10.05 8 447664 24 110141603
Cystitis haemorrhagic 25.10 10.05 9 447663 12200 110129427
Injection site swelling 25.00 10.05 147 447525 61643 110079984
Renal cyst 24.96 10.05 142 447530 18030 110123597
Embolic stroke 24.87 10.05 85 447587 8658 110132969
Heavy menstrual bleeding 24.80 10.05 18 447654 16347 110125280
Cerebrospinal fluid retention 24.72 10.05 11 447661 99 110141528
Pre-eclampsia 24.65 10.05 3 447669 8647 110132980
Thrombosis 24.64 10.05 595 447077 108067 110033560
Hepatitis cholestatic 24.61 10.05 138 447534 17428 110124199
Hypogammaglobulinaemia 24.52 10.05 27 447645 20049 110121578
Upper motor neurone lesion 24.46 10.05 16 447656 328 110141299
Scrotal oedema 24.35 10.05 32 447640 1649 110139978
Pharyngeal oedema 24.32 10.05 131 447541 16297 110125330
Acquired claw toe 24.20 10.05 9 447663 48 110141579
Drug tolerance 24.16 10.05 19 447653 16566 110125061
Tongue oedema 24.13 10.05 81 447591 8175 110133452
Cerebral arteriosclerosis 24.09 10.05 23 447649 829 110140798
Ageusia 24.09 10.05 149 447523 19496 110122131
Visual acuity reduced 24.03 10.05 217 447455 31956 110109671
Gastrooesophageal reflux disease 23.96 10.05 550 447122 179426 109962201
Macular degeneration 23.93 10.05 160 447512 21499 110120128
Pleurothotonus 23.76 10.05 39 447633 2459 110139168
Carotid artery thrombosis 23.74 10.05 5 447667 9633 110131994
Completed suicide 23.65 10.05 774 446898 241607 109900020
Colitis ulcerative 23.50 10.05 200 447472 77163 110064464
Blood calcium increased 23.50 10.05 139 447533 17901 110123726
Osteochondrosis 23.49 10.05 39 447633 2482 110139145
Malignant spinal cord compression 23.26 10.05 12 447660 154 110141473
Torsade de pointes 23.22 10.05 164 447508 22436 110119191
Respiratory tract congestion 23.20 10.05 57 447615 30800 110110827
Respiratory tract infection 23.19 10.05 182 447490 71435 110070192
Wound dehiscence 23.17 10.05 78 447594 7884 110133743
Immune reconstitution inflammatory syndrome 23.12 10.05 19 447653 16207 110125420
Pancreatic carcinoma 22.98 10.05 120 447552 14752 110126875
Coma 22.98 10.05 337 447335 117532 110024095
Orthopnoea 22.95 10.05 97 447575 10924 110130703
Left ventricular failure 22.77 10.05 99 447573 11290 110130337
Ketoacidosis 22.76 10.05 91 447581 9996 110131631
Sudden death 22.76 10.05 173 447499 24222 110117405
Genital ulcer syndrome 22.57 10.05 5 447667 0 110141627
Supraventricular extrasystoles 22.54 10.05 78 447594 7995 110133632
Helicobacter gastritis 22.43 10.05 39 447633 2577 110139050
Product administered to patient of inappropriate age 22.38 10.05 3 447669 8033 110133594
Subacute cutaneous lupus erythematosus 22.30 10.05 57 447615 4937 110136690
Alveolitis 22.30 10.05 53 447619 4386 110137241
Lymphocyte count decreased 22.21 10.05 138 447534 57105 110084522
Joint stiffness 22.19 10.05 170 447502 67073 110074554
Erosive duodenitis 22.10 10.05 36 447636 2255 110139372
Urine output decreased 22.06 10.05 147 447525 19729 110121898
Post viral fatigue syndrome 22.05 10.05 14 447658 272 110141355
Forced expiratory volume decreased 21.99 10.05 13 447659 13163 110128464
Left ventricular hypertrophy 21.96 10.05 109 447563 13135 110128492
Polyneuropathy 21.95 10.05 212 447460 31800 110109827
Atrioventricular block second degree 21.94 10.05 78 447594 8103 110133524
Viral myositis 21.92 10.05 9 447663 65 110141562
Abdominal distension 21.90 10.05 892 446780 174211 109967416
Febrile bone marrow aplasia 21.87 10.05 23 447649 17442 110124185
Duodenal ulcer haemorrhage 21.87 10.05 77 447595 7960 110133667
Myxoedema coma 21.87 10.05 20 447652 682 110140945
Subacute hepatic failure 21.84 10.05 13 447659 224 110141403
Vision blurred 21.75 10.05 680 446992 128342 110013285
Apolipoprotein A-I decreased 21.73 10.05 7 447665 22 110141605
Platelet count normal 21.73 10.05 7 447665 22 110141605
Weight fluctuation 21.73 10.05 35 447637 22110 110119517
Bundle branch block right 21.70 10.05 103 447569 12188 110129439
Pseudomonal sepsis 21.66 10.05 5 447667 9041 110132586
Spermatozoa abnormal 21.62 10.05 6 447666 9 110141618
Coronary angioplasty 21.47 10.05 16 447656 407 110141220
Basal ganglia haemorrhage 21.47 10.05 32 447640 1856 110139771
Large intestine polyp 21.34 10.05 119 447553 14998 110126629
Troponin increased 21.34 10.05 199 447473 29567 110112060
Motor neurone disease 21.34 10.05 20 447652 704 110140923
Paresis 21.34 10.05 55 447617 4789 110136838
Pollakiuria 21.29 10.05 273 447399 43922 110097705
Burns second degree 21.27 10.05 3 447669 7730 110133897
Fear of injection 21.19 10.05 5 447667 8906 110132721
Hypertensive heart disease 21.09 10.05 53 447619 4543 110137084
Hypovolaemia 20.95 10.05 155 447517 21519 110120108
Hyperammonaemia 20.94 10.05 15 447657 13717 110127910
Benign prostatic hyperplasia 20.93 10.05 136 447536 18098 110123529
Vaginal flatulence 20.89 10.05 101 447571 12043 110129584
Duodenal ulcer repair 20.82 10.05 9 447663 75 110141552
Eye swelling 20.79 10.05 215 447457 32833 110108794
Eructation 20.75 10.05 112 447560 13945 110127682
Neuropathy, ataxia, retinitis pigmentosa syndrome 20.74 10.05 8 447664 48 110141579
Visual impairment 20.72 10.05 701 446971 133727 110007900
Spontaneous haemorrhage 20.68 10.05 25 447647 1183 110140444
Leukocyturia 20.66 10.05 35 447637 2265 110139362
Non-cardiac chest pain 20.66 10.05 89 447583 10109 110131518
Flatulence 20.61 10.05 311 447361 51838 110089789
Rhinovirus infection 20.58 10.05 11 447661 11778 110129849
Hypoglycaemic coma 20.55 10.05 59 447613 5474 110136153
Occupational problem environmental 20.54 10.05 6 447666 12 110141615
Productive cough 20.52 10.05 332 447340 113973 110027654
Blood urine present 20.45 10.05 168 447504 24077 110117550
Polymyalgia rheumatica 20.44 10.05 65 447607 6377 110135250
Oral herpes 20.41 10.05 76 447596 36004 110105623
White blood cell count decreased 20.41 10.05 741 446931 228649 109912978
Pulmonary oedema 20.41 10.05 543 447129 100116 110041511
Cerebral artery occlusion 20.32 10.05 32 447640 1948 110139679
Cardiotoxicity 20.29 10.05 23 447649 16858 110124769
Polyuria 20.18 10.05 132 447540 17606 110124021
Postprandial hypoglycaemia 20.18 10.05 11 447661 159 110141468
Oesophageal obstruction 20.11 10.05 25 447647 1218 110140409
Candida infection 20.08 10.05 113 447559 47896 110093731
Personality change 20.01 10.05 93 447579 10909 110130718
Gestational diabetes 20.01 10.05 3 447669 7386 110134241
Nodular rash 20.00 10.05 14 447658 322 110141305
Parkinsonism 19.95 10.05 156 447516 22031 110119596
Electrocardiogram QT prolonged 19.91 10.05 580 447092 108380 110033247
Proctitis 19.89 10.05 127 447545 16800 110124827
Cerebral ventricular rupture 19.82 10.05 16 447656 459 110141168
Vasculitic rash 19.82 10.05 34 447638 2223 110139404
Sickle cell anaemia with crisis 19.68 10.05 7 447665 9538 110132089
Abdominal pain 19.65 10.05 2368 445304 510621 109631006
Prostate cancer metastatic 19.62 10.05 54 447618 4889 110136738
Nodule 19.62 10.05 67 447605 32564 110109063
Maternal exposure before pregnancy 19.56 10.05 3 447669 7262 110134365
Paralysis 19.55 10.05 119 447553 15481 110126146
Systemic candida 19.43 10.05 8 447664 9966 110131661
Nasal polyps 19.38 10.05 15 447657 13185 110128442
Posterior reversible encephalopathy syndrome 19.37 10.05 71 447601 33790 110107837
Impaired quality of life 19.18 10.05 60 447612 29957 110111670
Transplant dysfunction 19.17 10.05 5 447667 8323 110133304
Pancreatic carcinoma metastatic 19.09 10.05 48 447624 4116 110137511
Biliary cirrhosis 19.05 10.05 12 447660 230 110141397
Disease recurrence 18.98 10.05 156 447516 60628 110080999
Hypoglycaemic unconsciousness 18.88 10.05 24 447648 1196 110140431
Sodium retention 18.87 10.05 12 447660 234 110141393
Blood electrolytes abnormal 18.83 10.05 32 447640 2076 110139551
Blindness transient 18.81 10.05 60 447612 5896 110135731
Electromyogram abnormal 18.81 10.05 10 447662 137 110141490
Nasal congestion 18.81 10.05 282 447390 98000 110043627
Lymphopenia 18.79 10.05 91 447581 40079 110101548
Aortic valve incompetence 18.65 10.05 91 447581 10890 110130737
Hip fracture 18.60 10.05 221 447451 34930 110106697
Intentional dose omission 18.54 10.05 33 447639 20047 110121580
Device dislocation 18.45 10.05 66 447606 31638 110109989
Infarction 18.43 10.05 55 447617 5214 110136413
Acidosis 18.41 10.05 155 447517 22376 110119251
Paraesthesia oral 18.40 10.05 213 447459 33458 110108169
Long QT syndrome 18.35 10.05 67 447605 7051 110134576
Pulmonary tuberculosis 18.34 10.05 7 447665 9132 110132495
Peripheral ischaemia 18.33 10.05 91 447581 10967 110130660
Vascular device infection 18.26 10.05 24 447648 16488 110125139
Respiratory syncytial virus infection 18.22 10.05 19 447653 14465 110127162
Bronchiectasis 18.06 10.05 81 447591 36412 110105215
Glycogen storage disease type IX 18.05 10.05 4 447668 0 110141627
Rebound effect 17.99 10.05 20 447652 14786 110126841
Prerenal failure 17.99 10.05 49 447623 4410 110137217
Cerebral haematoma 17.95 10.05 82 447590 9550 110132077
Prothrombin time abnormal 17.94 10.05 24 447648 1258 110140369
Neck pain 17.91 10.05 371 447301 122759 110018868
Arteriosclerotic gangrene 17.88 10.05 8 447664 73 110141554
Hepatic function abnormal 17.86 10.05 254 447418 89041 110052586
Pneumonia fungal 17.85 10.05 20 447652 14734 110126893
Injection site rash 17.81 10.05 43 447629 23376 110118251
Diastolic dysfunction 17.75 10.05 98 447574 12306 110129321
Mitral valve stenosis 17.74 10.05 25 447647 1377 110140250
Sneezing 17.69 10.05 68 447604 31916 110109711
Blood lactic acid 17.66 10.05 15 447657 463 110141164
Dysgeusia 17.65 10.05 389 447283 69596 110072031
Chronic sinusitis 17.63 10.05 167 447505 24917 110116710
Dystonia 17.62 10.05 50 447622 25755 110115872
Peripheral coldness 17.59 10.05 132 447540 18408 110123219
Bladder obstruction 17.56 10.05 16 447656 543 110141084
Thrombocytopenia 17.53 10.05 1196 446476 347689 109793938
Tendonitis 17.52 10.05 172 447500 25911 110115716
Biopsy muscle abnormal 17.48 10.05 7 447665 47 110141580
Linear IgA disease 17.47 10.05 48 447624 4341 110137286
Carotid bruit 17.34 10.05 18 447654 719 110140908
White blood cell count increased 17.28 10.05 514 447158 96328 110045299
Fear of death 17.19 10.05 27 447645 1640 110139987
Cutaneous vasculitis 17.18 10.05 99 447573 12630 110128997
Amaurosis fugax 17.17 10.05 33 447639 2357 110139270
Low turnover osteopathy 17.15 10.05 30 447642 1992 110139635
Ataxia 17.14 10.05 192 447480 29916 110111711
Thrombosis in device 17.14 10.05 54 447618 5273 110136354
Sleep attacks 17.05 10.05 11 447661 220 110141407
Pulmonary vasculitis 17.01 10.05 3 447669 6557 110135070
Contracted bladder 16.96 10.05 6 447666 27 110141600
Pancreatitis chronic 16.96 10.05 48 447624 4417 110137210
Cytomegalovirus chorioretinitis 16.95 10.05 4 447668 7124 110134503
Stent placement 16.92 10.05 66 447606 7168 110134459
Stress 16.91 10.05 552 447120 104796 110036831
Genital swelling 16.79 10.05 14 447658 421 110141206
Enterocolitis 16.73 10.05 32 447640 18917 110122710
Pruritus 16.71 10.05 2080 445592 579480 109562147
Tenosynovitis 16.68 10.05 25 447647 16258 110125369
Cytomegalovirus test positive 16.63 10.05 4 447668 7032 110134595
Hypopnoea 16.62 10.05 13 447659 11367 110130260
Tuberculosis 16.60 10.05 29 447643 17745 110123882
Poliomyelitis 16.55 10.05 7 447665 55 110141572
Barrett's oesophagus 16.54 10.05 17 447655 671 110140956
Blood urine 16.54 10.05 20 447652 947 110140680
Shock hypoglycaemic 16.46 10.05 11 447661 234 110141393
Respiratory depression 16.46 10.05 70 447602 31931 110109696
Exercise lack of 16.44 10.05 15 447657 510 110141117
Uveitis 16.40 10.05 40 447632 21670 110119957
Tachycardia 16.38 10.05 1096 446576 225549 109916078
Pneumatosis intestinalis 16.36 10.05 7 447665 8522 110133105
Crystal nephropathy 16.35 10.05 28 447644 1828 110139799
Carotid artery disease 16.34 10.05 31 447641 2192 110139435
Change of bowel habit 16.34 10.05 36 447636 2833 110138794
Left ventricular dysfunction 16.31 10.05 156 447516 23337 110118290
Venoocclusive disease 16.26 10.05 3 447669 6347 110135280
Complications of transplanted kidney 16.15 10.05 5 447667 7437 110134190
Muscle contractions involuntary 16.13 10.05 47 447625 4397 110137230
Diffuse large B-cell lymphoma recurrent 16.08 10.05 3 447669 6296 110135331
Skin laceration 16.05 10.05 208 447464 33545 110108082
Diabetic hyperosmolar coma 15.99 10.05 19 447653 883 110140744
Brain stem infarction 15.99 10.05 30 447642 2104 110139523
Breast cancer stage I 15.96 10.05 5 447667 7382 110134245
Uterine perforation 15.95 10.05 4 447668 6836 110134791
Osteonecrosis of external auditory canal 15.94 10.05 11 447661 247 110141380
Intercepted product preparation error 15.88 10.05 4 447668 6816 110134811
Occult blood positive 15.88 10.05 66 447606 7379 110134248
Renal tubular necrosis 15.86 10.05 191 447481 30284 110111343
Skin wrinkling 15.80 10.05 25 447647 1528 110140099
Prescribed underdose 15.79 10.05 178 447494 64996 110076631
Catarrh 15.79 10.05 5 447667 7330 110134297
Adrenal cyst 15.75 10.05 11 447661 252 110141375
Malaise 15.70 10.05 3016 444656 668803 109472824
Neutropenic sepsis 15.70 10.05 192 447480 30554 110111073
Macroenzyme creatine kinase 15.70 10.05 5 447667 15 110141612
Penile curvature 15.70 10.05 5 447667 15 110141612
Ocular ischaemic syndrome 15.69 10.05 6 447666 35 110141592
Vascular graft occlusion 15.68 10.05 17 447655 714 110140913
Listless 15.67 10.05 47 447625 4468 110137159
Iron deficiency anaemia 15.65 10.05 196 447476 31363 110110264
Ventricular hypokinesia 15.65 10.05 88 447584 11126 110130501
Dermatitis bullous 15.62 10.05 123 447549 17406 110124221
Iron deficiency 15.57 10.05 128 447544 18348 110123279
Feeling hot 15.57 10.05 267 447405 90839 110050788
Secretion discharge 15.53 10.05 37 447635 20207 110121420
Genital haemorrhage 15.51 10.05 5 447667 7247 110134380
Thalamic infarction 15.49 10.05 23 447649 1329 110140298
Hepatitis toxic 15.49 10.05 56 447616 5865 110135762
Illness anxiety disorder 15.49 10.05 11 447661 259 110141368
Cardiac stress test abnormal 15.47 10.05 18 447654 818 110140809
Loose tooth 15.44 10.05 38 447634 3215 110138412
Product quality issue 15.42 10.05 220 447452 77079 110064548
Vulvovaginal burning sensation 15.39 10.05 29 447643 2040 110139587
Pancreatic neoplasm 15.34 10.05 27 447645 1802 110139825
Dry eye 15.30 10.05 148 447524 55645 110085982
Contusion 15.30 10.05 780 446892 232581 109909046
Spondylitis 15.28 10.05 14 447658 11324 110130303
Somnolence 15.18 10.05 1400 446272 296049 109845578
Intentional self-injury 15.17 10.05 89 447583 37340 110104287
Blood creatine increased 15.15 10.05 89 447583 11432 110130195
Muscle fatigue 15.14 10.05 43 447629 3964 110137663
Sepsis 15.13 10.05 1530 446142 325816 109815811
Carcinogenicity 15.13 10.05 9 447663 155 110141472
Raynaud's phenomenon 15.12 10.05 19 447653 936 110140691
Osteoma 15.09 10.05 8 447664 109 110141518
PCO2 decreased 15.08 10.05 37 447635 3124 110138503
Mydriasis 15.08 10.05 43 447629 22114 110119513
Akathisia 15.02 10.05 29 447643 17084 110124543
Bradyarrhythmia 14.95 10.05 49 447623 4885 110136742
Alcohol poisoning 14.91 10.05 9 447663 9011 110132616
Haemorrhage 14.87 10.05 550 447122 106142 110035485
Hypoglycaemic seizure 14.85 10.05 19 447653 953 110140674
Degenerative aortic valve disease 14.83 10.05 10 447662 216 110141411
Sinus disorder 14.82 10.05 75 447597 32653 110108974
Ocular myasthenia 14.81 10.05 17 447655 761 110140866
Fracture blisters 14.76 10.05 7 447665 74 110141553
Neurotoxicity 14.74 10.05 105 447567 42102 110099525
Antipsychotic drug level decreased 14.74 10.05 23 447649 1389 110140238
Brucellosis 14.73 10.05 9 447663 163 110141464
Second primary malignancy 14.69 10.05 32 447640 18036 110123591
Anal fistula 14.66 10.05 8 447664 8465 110133162
Ischaemic cerebral infarction 14.62 10.05 35 447637 2910 110138717
Subdural hygroma 14.61 10.05 15 447657 591 110141036
Parkinson's disease 14.60 10.05 24 447648 1515 110140112
Nocardiosis 14.59 10.05 6 447666 7480 110134147
Auricular swelling 14.59 10.05 9 447663 166 110141461
Neuromyopathy 14.58 10.05 26 447646 1753 110139874
Parainfluenzae virus infection 14.58 10.05 5 447667 6969 110134658
Extremity necrosis 14.56 10.05 41 447631 3761 110137866
Drug specific antibody present 14.53 10.05 8 447664 8426 110133201
Back pain 14.51 10.05 1715 445957 369281 109772346
Pneumonia cytomegaloviral 14.51 10.05 5 447667 6949 110134678
Rotator cuff syndrome 14.51 10.05 117 447555 16677 110124950
Hypomania 14.49 10.05 12 447660 10198 110131429
Medical device site thrombosis 14.41 10.05 8 447664 120 110141507
Pulmonary arterial wedge pressure decreased 14.41 10.05 4 447668 6 110141621
Parakeratosis 14.38 10.05 14 447658 517 110141110
Conjunctival discolouration 14.36 10.05 8 447664 121 110141506
Necrosis 14.29 10.05 87 447585 11319 110130308
Polyarthritis 14.28 10.05 35 447637 18928 110122699
Polycystic liver disease 14.26 10.05 9 447663 173 110141454
Intestinal obstruction 14.26 10.05 142 447530 53085 110088542
Eye haemorrhage 14.25 10.05 89 447583 11685 110129942
Sarcoidosis 14.20 10.05 18 447654 12561 110129066
Job dissatisfaction 14.20 10.05 7 447665 81 110141546
Impatience 14.19 10.05 17 447655 797 110140830
Anaphylactic reaction 14.19 10.05 353 447319 113947 110027680
Psychiatric decompensation 14.18 10.05 3 447669 5762 110135865
Vertigo 14.16 10.05 456 447216 86414 110055213
Dementia 14.15 10.05 193 447479 31480 110110147
Vertebral artery stenosis 14.14 10.05 10 447662 234 110141393
Neoplasm prostate 14.13 10.05 9 447663 176 110141451
Blood pressure difference of extremities 14.05 10.05 5 447667 23 110141604
Cushingoid 14.03 10.05 16 447656 11696 110129931
Inhibitory drug interaction 13.99 10.05 48 447624 4899 110136728
Lichen myxoedematosus 13.99 10.05 6 447666 49 110141578
Product used for unknown indication 13.97 10.05 27 447645 1936 110139691
Spinal fusion surgery 13.96 10.05 10 447662 9146 110132481
Epididymitis 13.96 10.05 31 447641 2453 110139174
Apathy 13.96 10.05 113 447559 16126 110125501
Haemoptysis 13.92 10.05 383 447289 70971 110070656
Serum ferritin abnormal 13.91 10.05 13 447659 456 110141171
Partner stress 13.89 10.05 11 447661 307 110141320
Pancreatic duct stenosis 13.88 10.05 10 447662 241 110141386
Gilbert's syndrome 13.88 10.05 5 447667 24 110141603
Intra-abdominal haematoma 13.85 10.05 38 447634 3434 110138193
Lordosis 13.82 10.05 13 447659 460 110141167
Articular calcification 13.81 10.05 10 447662 243 110141384
Urinary bladder polyp 13.81 10.05 10 447662 243 110141384
Sinus rhythm 13.80 10.05 19 447653 1024 110140603
Hepatomegaly 13.80 10.05 140 447532 21274 110120353
Hand-eye coordination impaired 13.78 10.05 6 447666 51 110141576
Syringe issue 13.76 10.05 11 447661 9514 110132113
Carcinoma in situ 13.75 10.05 8 447664 132 110141495
Splenic necrosis 13.69 10.05 9 447663 186 110141441
Female genital tract fistula 13.69 10.05 114 447558 16405 110125222
Ovarian cyst 13.68 10.05 22 447650 13908 110127719
Urine viscosity increased 13.68 10.05 6 447666 52 110141575
Angioimmunoblastic T-cell lymphoma 13.67 10.05 15 447657 639 110140988
Bladder trabeculation 13.63 10.05 7 447665 89 110141538
Infusion site erythema 13.62 10.05 17 447655 11942 110129685
Activated partial thromboplastin time shortened 13.60 10.05 19 447653 1038 110140589
Leukopenia 13.60 10.05 479 447193 148312 109993315
Walking disability 13.59 10.05 31 447641 2497 110139130
Ureteric injury 13.59 10.05 8 447664 135 110141492
Neuropathic muscular atrophy 13.49 10.05 6 447666 54 110141573
Toxic shock syndrome 13.48 10.05 23 447649 1497 110140130
Exfoliative rash 13.48 10.05 45 447627 4529 110137098
Bladder transitional cell carcinoma 13.48 10.05 33 447639 2783 110138844
Dental examination abnormal 13.38 10.05 4 447668 9 110141618
Fungaemia 13.37 10.05 4 447668 6082 110135545
Coma scale abnormal 13.36 10.05 76 447596 9650 110131977
Deafness 13.30 10.05 166 447506 26543 110115084
Peripheral embolism 13.29 10.05 27 447645 2008 110139619
Coronary artery restenosis 13.26 10.05 20 447652 1172 110140455
Hyperprolactinaemia 13.26 10.05 5 447667 6570 110135057
Spirometry abnormal 13.24 10.05 3 447669 5494 110136133
Coronavirus test positive 13.24 10.05 21 447651 1286 110140341
Bladder cancer 13.24 10.05 133 447539 20159 110121468
Orbital swelling 13.23 10.05 7 447665 95 110141532
Pernicious anaemia 13.22 10.05 16 447656 758 110140869
Prostatic specific antigen abnormal 13.20 10.05 15 447657 664 110140963
Muscle haemorrhage 13.19 10.05 59 447613 6810 110134817
Lumbar radiculopathy 13.19 10.05 31 447641 2547 110139080
Facial paralysis 13.15 10.05 153 447519 24061 110117566
Psychological trauma 13.14 10.05 24 447648 1649 110139978
Nasal ulcer 13.12 10.05 31 447641 2556 110139071
Puncture site haematoma 13.10 10.05 10 447662 264 110141363
Intestinal angioedema 13.06 10.05 19 447653 1078 110140549
Preternatural anus 13.04 10.05 7 447665 98 110141529
Oliguria 13.01 10.05 124 447548 18533 110123094
Cutis laxa 12.99 10.05 8 447664 147 110141480
Vulvar basal cell carcinoma 12.96 10.05 5 447667 30 110141597
Altered state of consciousness 12.95 10.05 160 447512 57466 110084161
Gastroenteritis 12.94 10.05 225 447447 38575 110103052
Depressed mood 12.90 10.05 330 447342 60479 110081148
Autoimmune myositis 12.89 10.05 18 447654 983 110140644
Product availability issue 12.87 10.05 8 447664 7882 110133745
Aortic valve calcification 12.86 10.05 17 447655 881 110140746
Herpes zoster 12.84 10.05 337 447335 108042 110033585
Parotid gland haemorrhage 12.82 10.05 5 447667 31 110141596
Drug-induced liver injury 12.77 10.05 379 447293 119688 110021939
Electrolyte depletion 12.77 10.05 13 447659 507 110141120
Dysstasia 12.76 10.05 196 447476 32790 110108837
Pseudoporphyria 12.75 10.05 16 447656 787 110140840
Aortic disorder 12.73 10.05 19 447653 1103 110140524
Coronary artery surgery 12.71 10.05 8 447664 153 110141474
Azotaemia 12.68 10.05 77 447595 10008 110131619
Intrapericardial thrombosis 12.68 10.05 6 447666 63 110141564
Drug level decreased 12.62 10.05 36 447636 18512 110123115
Coronavirus infection 12.61 10.05 12 447660 9533 110132094
Intracardiac thrombus 12.59 10.05 42 447630 4226 110137401
Wrong patient received product 12.57 10.05 57 447615 6617 110135010
Myoglobin urine present 12.54 10.05 17 447655 903 110140724
Femoral artery embolism 12.52 10.05 6 447666 65 110141562
Joint effusion 12.52 10.05 43 447629 20862 110120765
Vascular graft 12.49 10.05 27 447645 2098 110139529
Endocrine ophthalmopathy 12.47 10.05 21 447651 1352 110140275
Herbal interaction 12.46 10.05 14 447658 612 110141015
Adenocarcinoma pancreas 12.45 10.05 28 447644 2235 110139392
Drug effective for unapproved indication 12.44 10.05 24 447648 14143 110127484
Gingivitis 12.44 10.05 78 447594 10253 110131374
Dementia Alzheimer's type 12.41 10.05 17 447655 912 110140715
Chronic coronary syndrome 12.39 10.05 10 447662 287 110141340
Peak expiratory flow rate abnormal 12.38 10.05 7 447665 109 110141518
Device breakage 12.38 10.05 23 447649 13746 110127881
Respiratory fatigue 12.36 10.05 10 447662 288 110141339
Hyporeflexia 12.32 10.05 41 447631 4119 110137508
Fracture 12.31 10.05 154 447518 24634 110116993
End stage renal disease 12.26 10.05 137 447535 21336 110120291
Food interaction 12.25 10.05 27 447645 2125 110139502
Injected limb mobility decreased 12.19 10.05 5 447667 36 110141591
Mean cell haemoglobin increased 12.14 10.05 50 447622 5567 110136060
Faecal calprotectin increased 12.13 10.05 6 447666 6713 110134914
Oesophageal ulcer 12.13 10.05 64 447608 7900 110133727
Immune-mediated enterocolitis 12.11 10.05 14 447658 10171 110131456
Pharyngitis streptococcal 12.10 10.05 22 447650 13255 110128372
Q fever 12.10 10.05 10 447662 297 110141330
Klebsiella infection 12.09 10.05 41 447631 19968 110121659
Malnutrition 12.07 10.05 63 447609 27216 110114411
Brain oedema 12.05 10.05 75 447597 31023 110110604
Eosinophilic cellulitis 12.04 10.05 10 447662 299 110141328
B-lymphocyte abnormalities 12.02 10.05 8 447664 169 110141458
Hypophosphataemia 12.01 10.05 195 447477 32987 110108640
Gastritis haemorrhagic 11.94 10.05 34 447638 3139 110138488
Inappropriate antidiuretic hormone secretion 11.91 10.05 198 447474 33653 110107974
Poisoning 11.90 10.05 69 447603 29036 110112591
Gallbladder enlargement 11.89 10.05 26 447646 2036 110139591
Chronic fatigue syndrome 11.86 10.05 21 447651 1408 110140219
Amylase increased 11.80 10.05 89 447583 12430 110129197
Acoustic neuroma 11.79 10.05 10 447662 308 110141319
Aerophagia 11.77 10.05 6 447666 75 110141552
Cytomegalovirus colitis 11.74 10.05 7 447665 7054 110134573
Coagulation time prolonged 11.71 10.05 32 447640 2885 110138742
Throat lesion 11.71 10.05 12 447660 472 110141155
Immunosuppression 11.70 10.05 35 447637 17724 110123903
Hyperventilation 11.69 10.05 69 447603 8878 110132749
Cardiac death 11.67 10.05 23 447649 1673 110139954
Stress fracture 11.67 10.05 59 447613 7162 110134465
Hypotonia 11.66 10.05 106 447566 15639 110125988
Pelvic mass 11.65 10.05 21 447651 1428 110140199
Hepatitis B reactivation 11.64 10.05 8 447664 7476 110134151
Drug monitoring procedure not performed 11.63 10.05 20 447652 1310 110140317
Neurological symptom 11.60 10.05 29 447643 15579 110126048
Gait inability 11.57 10.05 443 447229 135933 110005694
Escherichia urinary tract infection 11.56 10.05 108 447564 16054 110125573
Tongue biting 11.56 10.05 32 447640 2907 110138720
Skin discolouration 11.55 10.05 270 447402 48776 110092851
Tongue dry 11.52 10.05 20 447652 1320 110140307
Sopor 11.51 10.05 210 447462 36336 110105291
Multiple endocrine neoplasia 11.47 10.05 3 447669 3 110141624
Calculus prostatic 11.47 10.05 3 447669 3 110141624
Therapy cessation 11.47 10.05 121 447551 44736 110096891
Multiple allergies 11.46 10.05 20 447652 12243 110129384
Hypersensitivity vasculitis 11.44 10.05 57 447615 6880 110134747
Drug tolerance decreased 11.42 10.05 65 447607 27475 110114152
Colitis ischaemic 11.42 10.05 116 447556 17634 110123993
Pancreatic mass 11.40 10.05 24 447648 1831 110139796
Death 11.37 10.05 2580 445092 696289 109445338
Lichen planus 11.37 10.05 35 447637 3375 110138252
Toe amputation 11.33 10.05 41 447631 4297 110137330
Carnitine palmitoyltransferase deficiency 11.31 10.05 4 447668 18 110141609
Dental plaque 11.30 10.05 6 447666 82 110141545
Status epilepticus 11.29 10.05 78 447594 31493 110110134
Vascular pseudoaneurysm 11.28 10.05 40 447632 4150 110137477
Blood pH decreased 11.25 10.05 43 447629 4626 110137001
Haemorrhoids 11.24 10.05 205 447467 35467 110106160
Blindness unilateral 11.24 10.05 73 447599 9713 110131914
Meibomianitis 11.24 10.05 6 447666 83 110141544
Gallbladder neoplasm 11.24 10.05 6 447666 83 110141544
Hepatic cytolysis 11.22 10.05 156 447516 54897 110086730
Hypovolaemic shock 11.22 10.05 99 447573 14484 110127143
Hepatitis C virus test positive 11.22 10.05 11 447661 410 110141217
Frustration tolerance decreased 11.20 10.05 67 447605 8664 110132963
Blood testosterone decreased 11.19 10.05 31 447641 2817 110138810
Differential white blood cell count abnormal 11.18 10.05 27 447645 2257 110139370
Polydipsia 11.17 10.05 61 447611 7627 110134000
Lymph node palpable 11.17 10.05 8 447664 191 110141436
Tendon pain 11.16 10.05 53 447619 6273 110135354
Pustular psoriasis 11.14 10.05 24 447648 13581 110128046
Paradoxical drug reaction 11.13 10.05 14 447658 9803 110131824
Gingival pain 11.11 10.05 30 447642 15706 110125921
Brain contusion 11.11 10.05 22 447650 1606 110140021
Prostate examination abnormal 11.10 10.05 8 447664 193 110141434
Guillain-Barre syndrome 11.06 10.05 78 447594 10666 110130961
Haemothorax 11.05 10.05 57 447615 6974 110134653
Pancreatic calcification 11.04 10.05 9 447663 262 110141365
Inguinal hernia 11.03 10.05 61 447611 7664 110133963
Unevaluable event 11.02 10.05 316 447356 58911 110082716
Sinus arrhythmia 11.00 10.05 26 447646 2144 110139483
Carcinoma in situ of skin 10.99 10.05 8 447664 196 110141431
Blood potassium decreased 10.99 10.05 292 447380 53822 110087805
Metastases to bone 10.98 10.05 78 447594 31294 110110333
Vascular skin disorder 10.97 10.05 4 447668 20 110141607
Psoriasis 10.97 10.05 459 447213 139534 110002093
Thrombin time prolonged 10.96 10.05 10 447662 340 110141287
Tessellated fundus 10.96 10.05 5 447667 48 110141579
Mesenteric arterial occlusion 10.95 10.05 9 447663 265 110141362
Peroneal nerve palsy 10.89 10.05 59 447613 7355 110134272
Myoclonus 10.88 10.05 191 447481 32807 110108820
Clostridium difficile infection 10.88 10.05 147 447525 51982 110089645
Atrophy 10.88 10.05 28 447644 2436 110139191
Anaemia postoperative 10.82 10.05 24 447648 1897 110139730
Gouty arthritis 10.82 10.05 22 447650 1637 110139990
Peptic ulcer 10.77 10.05 60 447612 7559 110134068
Blood pressure orthostatic 10.75 10.05 6 447666 91 110141536
Gastroenteritis viral 10.75 10.05 78 447594 31148 110110479
Menstruation irregular 10.74 10.05 5 447667 5792 110135835
Gastric mucosa erythema 10.73 10.05 12 447660 522 110141105
Coronary artery reocclusion 10.72 10.05 7 447665 143 110141484
Volvulus 10.71 10.05 35 447637 3483 110138144
JC virus infection 10.70 10.05 4 447668 5286 110136341
Gastric cyst 10.70 10.05 6 447666 92 110141535
Vestibular disorder 10.69 10.05 29 447643 2603 110139024
General symptom 10.69 10.05 12 447660 8834 110132793
Vein discolouration 10.66 10.05 11 447661 436 110141191
Sensitivity to weather change 10.66 10.05 15 447657 10013 110131614
Rectal cancer stage III 10.66 10.05 4 447668 22 110141605
Multiple drug therapy 10.60 10.05 62 447610 7952 110133675
Injection site urticaria 10.59 10.05 35 447637 17180 110124447
Essential hypertension 10.57 10.05 61 447611 7786 110133841
Trifascicular block 10.55 10.05 8 447664 209 110141418
Intestinal ischaemia 10.53 10.05 106 447566 16073 110125554
Neutrophil count increased 10.52 10.05 198 447474 34454 110107173
Laryngeal pain 10.50 10.05 50 447622 5925 110135702
Retinal vascular thrombosis 10.45 10.05 8 447664 212 110141415
Diabetic retinopathy 10.45 10.05 35 447637 3529 110138098
Hepatitis C 10.45 10.05 22 447650 12551 110129076
Avoidant personality disorder 10.42 10.05 6 447666 97 110141530
Daydreaming 10.41 10.05 18 447654 1184 110140443
Secondary immunodeficiency 10.40 10.05 3 447669 4673 110136954
Splenic cyst 10.37 10.05 9 447663 286 110141341
Activated partial thromboplastin time abnormal 10.30 10.05 10 447662 368 110141259
Loss of libido 10.30 10.05 32 447640 3101 110138526
Lupus nephritis 10.30 10.05 3 447669 4642 110136985
Femoral artery aneurysm 10.29 10.05 8 447664 217 110141410
Visual field defect 10.29 10.05 73 447599 9999 110131628
Actinic cheilitis 10.27 10.05 3 447669 6 110141621
Mitral valve sclerosis 10.24 10.05 10 447662 371 110141256
Salivary gland enlargement 10.22 10.05 11 447661 458 110141169
Personality disorder 10.22 10.05 23 447649 12814 110128813
Complication of device removal 10.21 10.05 3 447669 4617 110137010
Acute myeloid leukaemia recurrent 10.21 10.05 4 447668 5135 110136492
Dilatation ventricular 10.21 10.05 38 447634 4037 110137590
Acetonaemia 10.18 10.05 12 447660 553 110141074
Post procedural complication 10.16 10.05 158 447514 26500 110115127
Drug therapeutic incompatibility 10.15 10.05 7 447665 157 110141470
Paraparesis 10.15 10.05 41 447631 4525 110137102
Hyperosmolar state 10.15 10.05 14 447658 756 110140871
Neuritis 10.13 10.05 9 447663 7390 110134237
Throat irritation 10.13 10.05 154 447518 53398 110088229
Trichoglossia 10.13 10.05 15 447657 865 110140762
CSF protein abnormal 10.10 10.05 4 447668 26 110141601
Total lung capacity abnormal 10.09 10.05 3 447669 4580 110137047
Lid lag 10.08 10.05 7 447665 159 110141468
Affect lability 10.07 10.05 40 447632 18597 110123030
Rabbit syndrome 10.06 10.05 10 447662 379 110141248

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BH51 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
ATC C10AA01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35664 EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77255 EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:173085 ferroptosis inducer
CHEBI has role CHEBI:176497 geroprotector
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D057847 Lipid Regulating Agents

Related Drugs by ATC class:

A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors 9 drugs
alogliptinevogliptingemigliptinlinagliptinrosuvastatinsaxagliptinsitagliptinteneligliptinvildagliptin
C10AA HMG CoA reductase inhibitors 7 drugs
atorvastatincerivastatinfluvastatinlovastatinpitavastatinpravastatinrosuvastatin
C10BA Combinations of various lipid modifying agents 9 drugs
atorvastatinbempedoic acidezetimibefenofibratelovastatinnicotinic acidpitavastatinpravastatinrosuvastatin
C10BX Lipid modifying agents in combination with other drugs 14 drugs
acetylsalicylic acidamlodipineatorvastatincandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilpravastatinramiprilrosuvastatin show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Hypoalphalipoproteinemia indication 190785000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Prevention of Transient Ischemic Attacks indication
Slow Progression of Coronary Artery Disease indication
Myocardial Infarction Prevention indication
Alopecia areata off-label use 68225006 DOID:986
Primary Prevention of Coronary Heart Disease off-label use
Myocardial Reinfarction Prevention off-label use
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Low blood pressure contraindication 45007003
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Gout contraindication 90560007 DOID:13189
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Hemorrhagic cerebral infarction contraindication 230706003
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Surgical procedure contraindication 387713003
Acute coronary syndrome contraindication 394659003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myopathy related to SLCO1B1 Gene Variant contraindication
SLCO1B1 Gene Variant for OATP1B1 Transporter Affecting Hepatic Clearance contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
10MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
20MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
20MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
40MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
40MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 7.77 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Nuclear receptor subfamily 4 group A member 2 Nuclear other EC50 5.29 CHEMBL
Acetylcholinesterase Enzyme Ki 5.74 CHEMBL
Cholinesterase Enzyme Ki 6.12 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.02 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.37 CHEMBL

External reference:

IDSource
4020400 VUID
N0000148200 NUI
D00434 KEGG_DRUG
4020400 VANDF
C0074554 UMLSCUI
CHEBI:9150 CHEBI
CHEMBL1064 ChEMBL_ID
D019821 MESH_DESCRIPTOR_UI
DB00641 DRUGBANK_ID
54454 PUBCHEM_CID
2955 IUPHAR_LIGAND_ID
6147 INN_ID
AGG2FN16EV UNII
36567 RXNORM
5465 MMSL
82969 MMSL
d00746 MMSL
003621 NDDF
387584000 SNOMEDCT_US
96304005 SNOMEDCT_US
A1BYZ PDB_CHEM_ID
AGG2FN16EV INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7992 TABLET, FILM COATED 10 mg ORAL ANDA 24 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7993 TABLET, FILM COATED 20 mg ORAL ANDA 24 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-8056 TABLET, FILM COATED 40 mg ORAL ANDA 26 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-486 TABLET, FILM COATED 20 mg ORAL ANDA 25 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-487 TABLET, FILM COATED 40 mg ORAL ANDA 25 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-907 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-908 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-050 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-051 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-052 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-053 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-054 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-681 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-682 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-683 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-684 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-685 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
ezetimibe and simvastatin HUMAN PRESCRIPTION DRUG LABEL 2 16714-778 TABLET 10 mg ORAL ANDA 26 sections
ezetimibe and simvastatin HUMAN PRESCRIPTION DRUG LABEL 2 16714-779 TABLET 20 mg ORAL ANDA 26 sections
ezetimibe and simvastatin HUMAN PRESCRIPTION DRUG LABEL 2 16714-780 TABLET 40 mg ORAL ANDA 26 sections
ezetimibe and simvastatin HUMAN PRESCRIPTION DRUG LABEL 2 16714-781 TABLET 80 mg ORAL ANDA 26 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-004 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-005 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-006 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-007 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-156 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
VYTORIN HUMAN PRESCRIPTION DRUG LABEL 2 21695-325 TABLET 20 mg ORAL NDA 28 sections
VYTORIN HUMAN PRESCRIPTION DRUG LABEL 2 21695-339 TABLET 40 mg ORAL NDA 28 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 21695-738 TABLET 5 mg ORAL ANDA 15 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 21695-739 TABLET 10 mg ORAL ANDA 15 sections