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pravastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihyperlipidaemic substances, HMG CoA reductase inhibitors | 2239 | 81093-37-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.57 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 300 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 47 % | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 18 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.46 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.50 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.78 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.247 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 2.312 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 3.972 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 3.327 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 55.620 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 51.960 | % | High | 1 |
| herg | hERG pIC50 | 4.533 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.972 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.483 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 52.880 | % | High | 1 |
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 | 21 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6,TGFBR1 | 4 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.400 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.977 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 26.002 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 54.310 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 3.811 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 1 | |
| pppb | Pig plasma protein binding (% unbound) | 46.040 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.036 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 22.233 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 86.400 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 48.040 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 901.571 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 31, 1991 | FDA | BRISTOL MYERS SQUIBB |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myalgia | 361.74 | 10.44 | 516 | 60991 | 174609 | 90392331 |
| Hand deformity | 185.84 | 10.44 | 3 | 61504 | 296359 | 90270581 |
| Acute kidney injury | 183.44 | 10.44 | 555 | 60952 | 319832 | 90247108 |
| Systemic lupus erythematosus | 173.38 | 10.44 | 21 | 61486 | 361875 | 90205065 |
| Glossodynia | 160.90 | 10.44 | 16 | 61491 | 321763 | 90245177 |
| Synovitis | 146.54 | 10.44 | 24 | 61483 | 329728 | 90237212 |
| Contraindicated product administered | 145.20 | 10.44 | 22 | 61485 | 320117 | 90246823 |
| Pericarditis | 144.50 | 10.44 | 10 | 61497 | 270141 | 90296799 |
| Helicobacter infection | 135.54 | 10.44 | 4 | 61503 | 226846 | 90340094 |
| Duodenal ulcer perforation | 128.34 | 10.44 | 5 | 61502 | 221283 | 90345657 |
| Wound | 128.21 | 10.44 | 25 | 61482 | 302955 | 90263985 |
| Infusion related reaction | 124.14 | 10.44 | 64 | 61443 | 416716 | 90150224 |
| Maternal exposure during pregnancy | 120.20 | 10.44 | 47 | 61460 | 360016 | 90206924 |
| Folliculitis | 117.22 | 10.44 | 5 | 61502 | 204348 | 90362592 |
| Lower respiratory tract infection | 116.49 | 10.44 | 16 | 61491 | 250643 | 90316297 |
| Product dose omission issue | 113.91 | 10.44 | 445 | 61062 | 291242 | 90275698 |
| Treatment failure | 109.42 | 10.44 | 35 | 61472 | 303893 | 90263047 |
| Fall | 103.72 | 10.44 | 619 | 60888 | 481191 | 90085749 |
| Impaired healing | 91.63 | 10.44 | 23 | 61484 | 234176 | 90332764 |
| Arthropathy | 88.85 | 10.44 | 71 | 61436 | 366171 | 90200769 |
| Swelling | 80.16 | 10.44 | 100 | 61407 | 418958 | 90147982 |
| Hyperkalaemia | 77.84 | 10.44 | 150 | 61357 | 64814 | 90502126 |
| Lactic acidosis | 73.76 | 10.44 | 127 | 61380 | 50336 | 90516604 |
| Exposure during pregnancy | 73.35 | 10.44 | 35 | 61472 | 238375 | 90328565 |
| Hepatic enzyme increased | 72.26 | 10.44 | 83 | 61424 | 360653 | 90206287 |
| Diarrhoea | 72.24 | 10.44 | 962 | 60545 | 938228 | 89628712 |
| Atrioventricular block second degree | 66.36 | 10.44 | 40 | 61467 | 4412 | 90562528 |
| Muscle injury | 65.97 | 10.44 | 19 | 61488 | 176635 | 90390305 |
| Ill-defined disorder | 65.26 | 10.44 | 22 | 61485 | 184869 | 90382071 |
| Fibromyalgia | 62.35 | 10.44 | 31 | 61476 | 206238 | 90360702 |
| Type 2 diabetes mellitus | 62.26 | 10.44 | 30 | 61477 | 203214 | 90363726 |
| Discomfort | 60.67 | 10.44 | 58 | 61449 | 274277 | 90292663 |
| Drug ineffective | 59.74 | 10.44 | 627 | 60880 | 1383671 | 89183269 |
| Chronic kidney disease | 59.04 | 10.44 | 115 | 61392 | 50076 | 90516864 |
| Blister | 58.66 | 10.44 | 52 | 61455 | 254946 | 90311994 |
| Irritable bowel syndrome | 57.16 | 10.44 | 35 | 61472 | 207413 | 90359527 |
| Joint swelling | 54.61 | 10.44 | 168 | 61339 | 503132 | 90063808 |
| Myopathy | 54.49 | 10.44 | 56 | 61451 | 13462 | 90553478 |
| Therapeutic product effect decreased | 54.34 | 10.44 | 65 | 61442 | 277506 | 90289434 |
| Bursitis | 51.34 | 10.44 | 13 | 61494 | 131641 | 90435299 |
| Liver injury | 51.00 | 10.44 | 26 | 61481 | 170541 | 90396399 |
| Hyponatraemia | 50.63 | 10.44 | 202 | 61305 | 133336 | 90433604 |
| Colitis microscopic | 50.08 | 10.44 | 49 | 61458 | 11110 | 90555830 |
| Drug intolerance | 49.55 | 10.44 | 148 | 61359 | 447443 | 90119497 |
| Gastrointestinal disorder | 49.30 | 10.44 | 61 | 61446 | 256626 | 90310314 |
| Pulseless electrical activity | 49.29 | 10.44 | 44 | 61463 | 8888 | 90558052 |
| Atrial fibrillation | 48.19 | 10.44 | 199 | 61308 | 133412 | 90433528 |
| Lip dry | 47.94 | 10.44 | 6 | 61501 | 100949 | 90465991 |
| Full blood count decreased | 47.75 | 10.44 | 78 | 61429 | 29611 | 90537329 |
| Blood glucose increased | 47.03 | 10.44 | 157 | 61350 | 95089 | 90471851 |
| Injury | 46.89 | 10.44 | 39 | 61468 | 197310 | 90369630 |
| Alopecia | 43.22 | 10.44 | 181 | 61326 | 494890 | 90072050 |
| Drug interaction | 43.00 | 10.44 | 328 | 61179 | 276125 | 90290815 |
| Inflammation | 42.79 | 10.44 | 35 | 61472 | 178557 | 90388383 |
| Abdominal discomfort | 42.61 | 10.44 | 173 | 61334 | 477155 | 90089785 |
| Musculoskeletal stiffness | 42.24 | 10.44 | 86 | 61421 | 296446 | 90270494 |
| BRASH syndrome | 41.93 | 10.44 | 22 | 61485 | 1857 | 90565083 |
| Mobility decreased | 41.75 | 10.44 | 66 | 61441 | 250668 | 90316272 |
| Infection | 41.31 | 10.44 | 118 | 61389 | 361976 | 90204964 |
| Urinary tract infection | 40.70 | 10.44 | 350 | 61157 | 305282 | 90261658 |
| Immune-mediated myositis | 39.34 | 10.44 | 23 | 61484 | 2398 | 90564542 |
| Insulin autoimmune syndrome | 39.25 | 10.44 | 11 | 61496 | 159 | 90566781 |
| Joint range of motion decreased | 38.61 | 10.44 | 22 | 61485 | 135621 | 90431319 |
| Decreased bronchial secretion | 38.12 | 10.44 | 9 | 61498 | 62 | 90566878 |
| Rhabdomyolysis | 37.29 | 10.44 | 97 | 61410 | 51159 | 90515781 |
| Hypersensitivity | 36.79 | 10.44 | 171 | 61336 | 454506 | 90112434 |
| Bezoar | 36.76 | 10.44 | 23 | 61484 | 2711 | 90564229 |
| Muscle spasms | 36.49 | 10.44 | 294 | 61213 | 251589 | 90315351 |
| Psoriatic arthropathy | 36.24 | 10.44 | 62 | 61445 | 228273 | 90338667 |
| Congenital coronary artery malformation | 35.40 | 10.44 | 10 | 61497 | 149 | 90566791 |
| General physical health deterioration | 34.05 | 10.44 | 125 | 61382 | 354990 | 90211950 |
| Urinary incontinence | 33.63 | 10.44 | 77 | 61430 | 37489 | 90529451 |
| Blood thyroid stimulating hormone normal | 33.21 | 10.44 | 9 | 61498 | 114 | 90566826 |
| Autoimmune disorder | 33.14 | 10.44 | 6 | 61501 | 76738 | 90490202 |
| Wheezing | 33.09 | 10.44 | 70 | 61437 | 238010 | 90328930 |
| Pulmonary fibrosis | 32.71 | 10.44 | 16 | 61491 | 107487 | 90459453 |
| Grip strength decreased | 32.68 | 10.44 | 11 | 61496 | 92565 | 90474375 |
| Interstitial lung disease | 32.58 | 10.44 | 120 | 61387 | 76285 | 90490655 |
| Red blood cell sedimentation rate increased | 32.50 | 10.44 | 8 | 61499 | 82587 | 90484353 |
| Anaemia | 32.38 | 10.44 | 374 | 61133 | 352428 | 90214512 |
| Prescribed overdose | 32.11 | 10.44 | 13 | 61494 | 97612 | 90469328 |
| Acute interstitial pneumonitis | 31.73 | 10.44 | 14 | 61493 | 805 | 90566135 |
| Vitamin B12 decreased | 30.98 | 10.44 | 27 | 61480 | 5283 | 90561657 |
| Tubulointerstitial nephritis | 30.94 | 10.44 | 59 | 61448 | 25284 | 90541656 |
| Rheumatoid arthritis | 30.74 | 10.44 | 134 | 61373 | 362480 | 90204460 |
| Drug abuse | 30.47 | 10.44 | 9 | 61498 | 82338 | 90484602 |
| Vaccination site pain | 30.24 | 10.44 | 11 | 61496 | 380 | 90566560 |
| Vertigo | 30.06 | 10.44 | 110 | 61397 | 69701 | 90497239 |
| Pancreatitis acute | 30.05 | 10.44 | 67 | 61440 | 32048 | 90534892 |
| Peripheral venous disease | 29.58 | 10.44 | 10 | 61497 | 83911 | 90483029 |
| Cardiac failure congestive | 28.78 | 10.44 | 138 | 61369 | 98556 | 90468384 |
| Loss of consciousness | 28.67 | 10.44 | 178 | 61329 | 140060 | 90426880 |
| Live birth | 28.63 | 10.44 | 9 | 61498 | 79098 | 90487842 |
| Back pain | 28.54 | 10.44 | 335 | 61172 | 316840 | 90250100 |
| Haematoma | 28.51 | 10.44 | 74 | 61433 | 38974 | 90527966 |
| Wound infection | 27.87 | 10.44 | 19 | 61488 | 106383 | 90460557 |
| Cerebral haemorrhage | 26.84 | 10.44 | 67 | 61440 | 34455 | 90532485 |
| Product use issue | 26.71 | 10.44 | 124 | 61383 | 329795 | 90237145 |
| Allergic sinusitis | 26.47 | 10.44 | 17 | 61490 | 2096 | 90564844 |
| Hypercholesterolaemia | 26.44 | 10.44 | 18 | 61489 | 100874 | 90466066 |
| Renal disorder | 25.87 | 10.44 | 70 | 61437 | 37789 | 90529151 |
| Bone erosion | 25.54 | 10.44 | 3 | 61504 | 53018 | 90513922 |
| Off label use | 25.34 | 10.44 | 563 | 60944 | 1101689 | 89465251 |
| Hip arthroplasty | 25.30 | 10.44 | 10 | 61497 | 76198 | 90490742 |
| Diabetic ketoacidosis | 25.22 | 10.44 | 53 | 61454 | 24354 | 90542586 |
| Obesity | 24.87 | 10.44 | 21 | 61486 | 105486 | 90461454 |
| Asthenia | 24.86 | 10.44 | 504 | 61003 | 533247 | 90033693 |
| Electrocardiogram PR prolongation | 24.73 | 10.44 | 12 | 61495 | 858 | 90566082 |
| Feeling abnormal | 24.63 | 10.44 | 196 | 61311 | 167039 | 90399901 |
| Cerebral infarction | 24.34 | 10.44 | 55 | 61452 | 26541 | 90540399 |
| Cough | 24.20 | 10.44 | 368 | 61139 | 368594 | 90198346 |
| Gastrointestinal haemorrhage | 24.04 | 10.44 | 123 | 61384 | 90125 | 90476815 |
| Pain in extremity | 23.90 | 10.44 | 434 | 61073 | 450095 | 90116845 |
| Atrioventricular block first degree | 23.57 | 10.44 | 29 | 61478 | 8482 | 90558458 |
| Restless legs syndrome | 23.46 | 10.44 | 49 | 61458 | 22421 | 90544519 |
| Priapism | 23.44 | 10.44 | 7 | 61500 | 128 | 90566812 |
| Psoriasis | 23.33 | 10.44 | 176 | 61331 | 147578 | 90419362 |
| Transient ischaemic attack | 22.95 | 10.44 | 73 | 61434 | 43103 | 90523837 |
| Post viral fatigue syndrome | 22.60 | 10.44 | 8 | 61499 | 255 | 90566685 |
| Glycosylated haemoglobin increased | 22.52 | 10.44 | 39 | 61468 | 15523 | 90551417 |
| Nasal congestion | 22.44 | 10.44 | 114 | 61393 | 83300 | 90483640 |
| Stomatitis | 22.37 | 10.44 | 103 | 61404 | 274595 | 90292345 |
| Night sweats | 22.28 | 10.44 | 33 | 61474 | 128733 | 90438207 |
| Dysgeusia | 21.94 | 10.44 | 82 | 61425 | 52478 | 90514462 |
| Foreign body sensation in eyes | 21.76 | 10.44 | 18 | 61489 | 3282 | 90563658 |
| Metabolic acidosis | 21.72 | 10.44 | 85 | 61422 | 55591 | 90511349 |
| Therapeutic product effect incomplete | 21.50 | 10.44 | 64 | 61443 | 193832 | 90373108 |
| C-reactive protein increased | 21.49 | 10.44 | 58 | 61449 | 181331 | 90385609 |
| Axonal neuropathy | 21.01 | 10.44 | 12 | 61495 | 1197 | 90565743 |
| Blood uric acid increased | 20.94 | 10.44 | 26 | 61481 | 7678 | 90559262 |
| Therapy non-responder | 20.88 | 10.44 | 38 | 61469 | 136666 | 90430274 |
| Constipation | 20.48 | 10.44 | 285 | 61222 | 280110 | 90286830 |
| Muscle rupture | 20.43 | 10.44 | 17 | 61490 | 3124 | 90563816 |
| Human ehrlichiosis | 20.40 | 10.44 | 7 | 61500 | 203 | 90566737 |
| Decreased appetite | 20.05 | 10.44 | 363 | 61144 | 376177 | 90190763 |
| Diabetes mellitus | 19.85 | 10.44 | 92 | 61415 | 64783 | 90502157 |
| COVID-19 | 19.71 | 10.44 | 188 | 61319 | 168655 | 90398285 |
| Blood loss anaemia | 19.60 | 10.44 | 29 | 61478 | 10111 | 90556829 |
| Melaena | 19.57 | 10.44 | 60 | 61447 | 34737 | 90532203 |
| Myelosuppression | 19.57 | 10.44 | 6 | 61501 | 53585 | 90513355 |
| Lower gastrointestinal haemorrhage | 19.49 | 10.44 | 27 | 61480 | 8865 | 90558075 |
| Intertrigo | 19.44 | 10.44 | 10 | 61497 | 810 | 90566130 |
| Dizziness | 19.31 | 10.44 | 530 | 60977 | 588754 | 89978186 |
| Sinus node dysfunction | 19.29 | 10.44 | 21 | 61486 | 5391 | 90561549 |
| Sinus arrhythmia | 19.00 | 10.44 | 12 | 61495 | 1437 | 90565503 |
| Cholestasis | 18.96 | 10.44 | 61 | 61446 | 36238 | 90530702 |
| Lower limb fracture | 18.74 | 10.44 | 18 | 61489 | 84995 | 90481945 |
| Inappropriate antidiuretic hormone secretion | 18.60 | 10.44 | 41 | 61466 | 19464 | 90547476 |
| Synovial disorder | 18.49 | 10.44 | 16 | 61491 | 3102 | 90563838 |
| Influenza | 18.25 | 10.44 | 159 | 61348 | 139105 | 90427835 |
| Postictal paralysis | 18.22 | 10.44 | 7 | 61500 | 282 | 90566658 |
| Renal tubular disorder | 18.10 | 10.44 | 16 | 61491 | 3191 | 90563749 |
| Device expulsion | 18.08 | 10.44 | 3 | 61504 | 40883 | 90526057 |
| Alexithymia | 18.05 | 10.44 | 5 | 61502 | 69 | 90566871 |
| Coronary artery disease | 18.01 | 10.44 | 57 | 61450 | 33566 | 90533374 |
| Epistaxis | 17.99 | 10.44 | 109 | 61398 | 85016 | 90481924 |
| Tinnitus | 17.79 | 10.44 | 67 | 61440 | 43035 | 90523905 |
| Death | 17.70 | 10.44 | 420 | 61087 | 456131 | 90110809 |
| Syncope | 17.67 | 10.44 | 152 | 61355 | 132511 | 90434429 |
| Hypoacusis | 17.55 | 10.44 | 50 | 61457 | 27800 | 90539140 |
| Sciatica | 17.52 | 10.44 | 26 | 61481 | 101356 | 90465584 |
| Bradycardia | 17.49 | 10.44 | 107 | 61400 | 83740 | 90483200 |
| Iron deficiency anaemia | 17.43 | 10.44 | 45 | 61462 | 23617 | 90543323 |
| Hyperlipidaemia | 17.32 | 10.44 | 44 | 61463 | 22872 | 90544068 |
| Hepatocellular injury | 17.29 | 10.44 | 51 | 61456 | 28907 | 90538033 |
| Intentional product use issue | 17.26 | 10.44 | 82 | 61425 | 216810 | 90350130 |
| Polymyalgia rheumatica | 17.20 | 10.44 | 19 | 61488 | 4958 | 90561982 |
| Fixed eruption | 17.07 | 10.44 | 12 | 61495 | 1718 | 90565222 |
| Viral infection | 16.78 | 10.44 | 64 | 61443 | 41350 | 90525590 |
| Product dispensing error | 16.78 | 10.44 | 30 | 61477 | 12243 | 90554697 |
| Foot deformity | 16.51 | 10.44 | 10 | 61497 | 59641 | 90507299 |
| Cardiac failure | 16.49 | 10.44 | 129 | 61378 | 109367 | 90457573 |
| Angina pectoris | 16.27 | 10.44 | 61 | 61446 | 39099 | 90527841 |
| Prothrombin time shortened | 16.23 | 10.44 | 13 | 61494 | 2265 | 90564675 |
| Adenocarcinoma metastatic | 16.03 | 10.44 | 6 | 61501 | 225 | 90566715 |
| Scratch | 15.97 | 10.44 | 26 | 61481 | 9840 | 90557100 |
| Dry gangrene | 15.68 | 10.44 | 8 | 61499 | 637 | 90566303 |
| Cardiac murmur functional | 15.62 | 10.44 | 4 | 61503 | 40 | 90566900 |
| Ear haemorrhage | 15.58 | 10.44 | 11 | 61496 | 1585 | 90565355 |
| Dehydration | 15.58 | 10.44 | 201 | 61306 | 194246 | 90372694 |
| Rhinorrhoea | 15.55 | 10.44 | 108 | 61399 | 88208 | 90478732 |
| Cutaneous T-cell lymphoma | 15.43 | 10.44 | 11 | 61496 | 1609 | 90565331 |
| Therapy cessation | 15.40 | 10.44 | 57 | 61450 | 36304 | 90530636 |
| Palpitations | 15.34 | 10.44 | 151 | 61356 | 136577 | 90430363 |
| Bronchitis | 15.31 | 10.44 | 165 | 61342 | 152762 | 90414178 |
| Pancreatic steatosis | 15.30 | 10.44 | 11 | 61496 | 1631 | 90565309 |
| Epilepsy | 15.28 | 10.44 | 20 | 61487 | 82186 | 90484754 |
| Erythematotelangiectatic rosacea | 15.28 | 10.44 | 5 | 61502 | 125 | 90566815 |
| Leukocytosis | 15.21 | 10.44 | 51 | 61456 | 30939 | 90536001 |
| Gastric infection | 15.17 | 10.44 | 16 | 61491 | 3964 | 90562976 |
| Vessel puncture site bruise | 15.14 | 10.44 | 7 | 61500 | 449 | 90566491 |
| Dysmetria | 15.12 | 10.44 | 8 | 61499 | 687 | 90566253 |
| Tooth disorder | 15.12 | 10.44 | 51 | 61456 | 31039 | 90535901 |
| Mixed liver injury | 15.02 | 10.44 | 22 | 61485 | 7601 | 90559339 |
| Dyspnoea exertional | 14.92 | 10.44 | 92 | 61415 | 72196 | 90494744 |
| Malaise | 14.90 | 10.44 | 511 | 60996 | 585475 | 89981465 |
| Dermatitis atopic | 14.65 | 10.44 | 42 | 61465 | 23430 | 90543510 |
| COVID-19 immunisation | 14.57 | 10.44 | 11 | 61496 | 1758 | 90565182 |
| Hepatitis cholestatic | 14.46 | 10.44 | 23 | 61484 | 8538 | 90558402 |
| Poor dental condition | 14.40 | 10.44 | 7 | 61500 | 503 | 90566437 |
| Gait inability | 14.38 | 10.44 | 51 | 61456 | 146405 | 90420535 |
| Drug hypersensitivity | 14.34 | 10.44 | 414 | 61093 | 463195 | 90103745 |
| Delirium | 14.23 | 10.44 | 31 | 61476 | 104328 | 90462612 |
| Toxic encephalopathy | 14.18 | 10.44 | 23 | 61484 | 8676 | 90558264 |
| Eye irritation | 14.17 | 10.44 | 53 | 61454 | 33925 | 90533015 |
| Ligament rupture | 14.16 | 10.44 | 15 | 61492 | 3733 | 90563207 |
| Peptic ulcer | 14.12 | 10.44 | 18 | 61489 | 5457 | 90561483 |
| Cholestatic liver injury | 14 | 10.44 | 15 | 61492 | 3782 | 90563158 |
| Pericardial haemorrhage | 13.99 | 10.44 | 11 | 61496 | 1865 | 90565075 |
| Onychomycosis | 13.98 | 10.44 | 4 | 61503 | 37372 | 90529568 |
| Hypokalaemia | 13.85 | 10.44 | 143 | 61364 | 130973 | 90435967 |
| Mammogram abnormal | 13.69 | 10.44 | 8 | 61499 | 833 | 90566107 |
| Skin depigmentation | 13.62 | 10.44 | 9 | 61498 | 1164 | 90565776 |
| Renal impairment | 13.62 | 10.44 | 120 | 61387 | 105301 | 90461639 |
| Essential hypertension | 13.58 | 10.44 | 19 | 61488 | 6296 | 90560644 |
| Pulmonary renal syndrome | 13.49 | 10.44 | 7 | 61500 | 578 | 90566362 |
| Enteritis infectious | 13.44 | 10.44 | 12 | 61495 | 2423 | 90564517 |
| Atrioventricular block complete | 13.43 | 10.44 | 24 | 61483 | 9787 | 90557153 |
| Tremor | 13.41 | 10.44 | 161 | 61346 | 153012 | 90413928 |
| Bacteriuria | 13.40 | 10.44 | 9 | 61498 | 1197 | 90565743 |
| Trigger finger | 13.34 | 10.44 | 17 | 61490 | 5153 | 90561787 |
| Potassium wasting nephropathy | 13.30 | 10.44 | 4 | 61503 | 75 | 90566865 |
| Hypovolaemic shock | 13.30 | 10.44 | 20 | 61487 | 7074 | 90559866 |
| Arterial thrombosis | 13.29 | 10.44 | 10 | 61497 | 1590 | 90565350 |
| Myopathy toxic | 13.17 | 10.44 | 7 | 61500 | 607 | 90566333 |
| Ligament sprain | 13.15 | 10.44 | 30 | 61477 | 14569 | 90552371 |
| Subarachnoid haemorrhage | 13.14 | 10.44 | 34 | 61473 | 17870 | 90549070 |
| Blood cholesterol increased | 13.08 | 10.44 | 85 | 61422 | 207927 | 90359013 |
| Blood iron decreased | 13.07 | 10.44 | 34 | 61473 | 17925 | 90549015 |
| Clostridium difficile infection | 13.07 | 10.44 | 54 | 61453 | 36191 | 90530749 |
| Coeliac disease | 13.03 | 10.44 | 7 | 61500 | 44603 | 90522337 |
| Colitis ischaemic | 12.98 | 10.44 | 27 | 61480 | 12319 | 90554621 |
| Vision blurred | 12.96 | 10.44 | 123 | 61384 | 110170 | 90456770 |
| Lung disorder | 12.92 | 10.44 | 55 | 61452 | 149828 | 90417112 |
| Knee arthroplasty | 12.81 | 10.44 | 23 | 61484 | 83159 | 90483781 |
| Eye haemorrhage | 12.80 | 10.44 | 24 | 61483 | 10156 | 90556784 |
| Alanine aminotransferase | 12.70 | 10.44 | 4 | 61503 | 88 | 90566852 |
| Oxygen saturation decreased | 12.70 | 10.44 | 120 | 61387 | 107363 | 90459577 |
| Hypochloraemia | 12.68 | 10.44 | 12 | 61495 | 2610 | 90564330 |
| Low density lipoprotein increased | 12.67 | 10.44 | 21 | 61486 | 8064 | 90558876 |
| Eczema | 12.67 | 10.44 | 70 | 61437 | 52800 | 90514140 |
| Uterine dilation and evacuation | 12.66 | 10.44 | 3 | 61504 | 21 | 90566919 |
| Hypoglycaemia | 12.64 | 10.44 | 86 | 61421 | 69762 | 90497178 |
| Cataract | 12.60 | 10.44 | 88 | 61419 | 72004 | 90494936 |
| Orthostatic hypotension | 12.56 | 10.44 | 59 | 61448 | 41768 | 90525172 |
| Blood creatine phosphokinase increased | 12.51 | 10.44 | 51 | 61456 | 33972 | 90532968 |
| Seborrhoeic keratosis | 12.50 | 10.44 | 13 | 61494 | 3167 | 90563773 |
| Head injury | 12.47 | 10.44 | 48 | 61459 | 31140 | 90535800 |
| Angular cheilitis | 12.41 | 10.44 | 8 | 61499 | 993 | 90565947 |
| Suicide attempt | 12.39 | 10.44 | 20 | 61487 | 75379 | 90491561 |
| Encephalopathy | 12.16 | 10.44 | 63 | 61444 | 46381 | 90520559 |
| Renal cyst | 12.10 | 10.44 | 27 | 61480 | 12923 | 90554017 |
| Small fibre neuropathy | 12.09 | 10.44 | 7 | 61500 | 717 | 90566223 |
| Peak expiratory flow rate abnormal | 12.04 | 10.44 | 4 | 61503 | 105 | 90566835 |
| Illness | 12.02 | 10.44 | 96 | 61411 | 81873 | 90485067 |
| Haematoma muscle | 12.01 | 10.44 | 10 | 61497 | 1840 | 90565100 |
| Platelet count decreased | 12.00 | 10.44 | 144 | 61363 | 136825 | 90430115 |
| Cerebral mass effect | 11.95 | 10.44 | 8 | 61499 | 1058 | 90565882 |
| Glycosuria | 11.95 | 10.44 | 9 | 61498 | 1433 | 90565507 |
| Ocular retrobulbar haemorrhage | 11.83 | 10.44 | 4 | 61503 | 111 | 90566829 |
| Nausea | 11.82 | 10.44 | 890 | 60617 | 1109426 | 89457514 |
| Symptom recurrence | 11.80 | 10.44 | 14 | 61493 | 3945 | 90562995 |
| Nightmare | 11.79 | 10.44 | 37 | 61470 | 21688 | 90545252 |
| Liver function test increased | 11.74 | 10.44 | 25 | 61482 | 84830 | 90482110 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 11.70 | 10.44 | 14 | 61493 | 3979 | 90562961 |
| Pancytopenia | 11.69 | 10.44 | 129 | 61378 | 120134 | 90446806 |
| Low density lipoprotein decreased | 11.63 | 10.44 | 5 | 61502 | 270 | 90566670 |
| Sinus congestion | 11.63 | 10.44 | 43 | 61464 | 27381 | 90539559 |
| Gastric ulcer | 11.60 | 10.44 | 43 | 61464 | 27405 | 90539535 |
| Fanconi syndrome | 11.58 | 10.44 | 10 | 61497 | 1933 | 90565007 |
| Adrenal insufficiency | 11.57 | 10.44 | 3 | 61504 | 29918 | 90537022 |
| Finger deformity | 11.45 | 10.44 | 4 | 61503 | 32893 | 90534047 |
| Heart rate abnormal | 11.43 | 10.44 | 17 | 61490 | 5954 | 90560986 |
| Upper-airway cough syndrome | 11.37 | 10.44 | 29 | 61478 | 15106 | 90551834 |
| Lipoma | 11.37 | 10.44 | 12 | 61495 | 2974 | 90563966 |
| Nail disorder | 11.37 | 10.44 | 14 | 61493 | 59053 | 90507887 |
| Hyperthermia | 11.33 | 10.44 | 23 | 61484 | 10312 | 90556628 |
| Back injury | 11.33 | 10.44 | 9 | 61498 | 46613 | 90520327 |
| Cerebrovascular accident | 11.32 | 10.44 | 131 | 61376 | 123402 | 90443538 |
| Left ventricular failure | 11.31 | 10.44 | 18 | 61489 | 6682 | 90560258 |
| Fatigue | 11.30 | 10.44 | 919 | 60588 | 1153104 | 89413836 |
| Hypersensitivity vasculitis | 11.24 | 10.44 | 14 | 61493 | 4145 | 90562795 |
| Immunosuppressant drug level decreased | 11.24 | 10.44 | 8 | 61499 | 1168 | 90565772 |
| Muscle discomfort | 11.19 | 10.44 | 5 | 61502 | 296 | 90566644 |
| Muscle spasticity | 11.14 | 10.44 | 5 | 61502 | 35317 | 90531623 |
| Plasma cell myeloma | 11.12 | 10.44 | 56 | 61451 | 40772 | 90526168 |
| Drug tolerance decreased | 11.03 | 10.44 | 4 | 61503 | 32126 | 90534814 |
| Blood glucose decreased | 11.01 | 10.44 | 38 | 61469 | 23391 | 90543549 |
| Blood triglycerides increased | 11.01 | 10.44 | 27 | 61480 | 13734 | 90553206 |
| Pyrexia | 11.00 | 10.44 | 353 | 61154 | 660132 | 89906808 |
| Sleep disorder | 10.94 | 10.44 | 84 | 61423 | 197946 | 90368994 |
| Limb discomfort | 10.93 | 10.44 | 53 | 61454 | 38007 | 90528933 |
| Skin test negative | 10.93 | 10.44 | 3 | 61504 | 40 | 90566900 |
| Paranasal sinus discomfort | 10.93 | 10.44 | 17 | 61490 | 6193 | 90560747 |
| Somnolence | 10.91 | 10.44 | 201 | 61306 | 208883 | 90358057 |
| Peripheral coldness | 10.84 | 10.44 | 27 | 61480 | 13865 | 90553075 |
| Pyuria | 10.83 | 10.44 | 10 | 61497 | 2109 | 90564831 |
| Acute abdomen | 10.82 | 10.44 | 9 | 61498 | 1654 | 90565286 |
| Dry skin | 10.74 | 10.44 | 99 | 61408 | 87974 | 90478966 |
| White blood cell count decreased | 10.67 | 10.44 | 166 | 61341 | 166943 | 90399997 |
| Hallucination | 10.65 | 10.44 | 79 | 61428 | 65880 | 90501060 |
| Arteriosclerosis | 10.56 | 10.44 | 23 | 61484 | 10830 | 90556110 |
| Throat clearing | 10.48 | 10.44 | 13 | 61494 | 3834 | 90563106 |
| Prescribed underdose | 10.46 | 10.44 | 22 | 61485 | 74997 | 90491943 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myalgia | 236.36 | 11.08 | 416 | 50331 | 95664 | 42474924 |
| Burns second degree | 105.13 | 11.08 | 74 | 50673 | 6022 | 42564566 |
| Catarrh | 104.01 | 11.08 | 73 | 50674 | 5913 | 42564675 |
| Parosmia | 100.44 | 11.08 | 79 | 50668 | 7612 | 42562976 |
| Hypopnoea | 96.61 | 11.08 | 78 | 50669 | 7804 | 42562784 |
| Steroid dependence | 96.42 | 11.08 | 73 | 50674 | 6649 | 42563939 |
| Gingival pain | 93.55 | 11.08 | 79 | 50668 | 8415 | 42562173 |
| Systemic lupus erythematosus | 89.14 | 11.08 | 80 | 50667 | 9244 | 42561344 |
| Impaired work ability | 85.76 | 11.08 | 88 | 50659 | 12003 | 42558585 |
| Drug abuse | 80.25 | 11.08 | 14 | 50733 | 104757 | 42465831 |
| Dysgeusia | 71.28 | 11.08 | 138 | 50609 | 34051 | 42536537 |
| IgM nephropathy | 70.49 | 11.08 | 19 | 50728 | 126 | 42570462 |
| Rhinitis | 68.84 | 11.08 | 78 | 50669 | 11899 | 42558689 |
| Acute kidney injury | 67.74 | 11.08 | 701 | 50046 | 366636 | 42203952 |
| Cardiac murmur | 66.40 | 11.08 | 79 | 50668 | 12696 | 42557892 |
| Blood creatine phosphokinase increased | 65.40 | 11.08 | 164 | 50583 | 48174 | 42522414 |
| Alcohol poisoning | 64.66 | 11.08 | 61 | 50686 | 7513 | 42563075 |
| Eczema | 64.35 | 11.08 | 132 | 50615 | 33954 | 42536634 |
| Cerebrovascular accident | 60.07 | 11.08 | 252 | 50495 | 96908 | 42473680 |
| Swollen tongue | 58.77 | 11.08 | 97 | 50650 | 21134 | 42549454 |
| Vertigo | 55.63 | 11.08 | 125 | 50622 | 34222 | 42536366 |
| Impaired quality of life | 52.28 | 11.08 | 74 | 50673 | 14103 | 42556485 |
| Shone complex | 50.23 | 11.08 | 13 | 50734 | 72 | 42570516 |
| Rectal haemorrhage | 48.95 | 11.08 | 150 | 50597 | 49456 | 42521132 |
| Lactic acidosis | 46.67 | 11.08 | 139 | 50608 | 45122 | 42525466 |
| Tubulointerstitial nephritis | 45.81 | 11.08 | 110 | 50637 | 31438 | 42539150 |
| Bronchiectasis | 45.47 | 11.08 | 79 | 50668 | 17940 | 42552648 |
| Tinnitus | 45.40 | 11.08 | 104 | 50643 | 28834 | 42541754 |
| Febrile neutropenia | 44.34 | 11.08 | 97 | 50650 | 185606 | 42384982 |
| Drug ineffective | 44.00 | 11.08 | 510 | 50237 | 629687 | 41940901 |
| Nightmare | 42.72 | 11.08 | 93 | 50654 | 24919 | 42545669 |
| Gastritis fungal | 38.36 | 11.08 | 12 | 50735 | 142 | 42570446 |
| Myopathy | 38.25 | 11.08 | 63 | 50684 | 13698 | 42556890 |
| Frequent bowel movements | 38.17 | 11.08 | 81 | 50666 | 21326 | 42549262 |
| Colitis ulcerative | 37.71 | 11.08 | 91 | 50656 | 26084 | 42544504 |
| Migraine | 37.31 | 11.08 | 89 | 50658 | 25325 | 42545263 |
| Pericarditis fungal | 37.18 | 11.08 | 13 | 50734 | 222 | 42570366 |
| Fall | 35.98 | 11.08 | 432 | 50315 | 234088 | 42336500 |
| Accidental overdose | 35.08 | 11.08 | 93 | 50654 | 28237 | 42542351 |
| Loss of control of legs | 34.85 | 11.08 | 18 | 50729 | 831 | 42569757 |
| Angina pectoris | 33.88 | 11.08 | 101 | 50646 | 32795 | 42537793 |
| Puncture site haematoma | 32.48 | 11.08 | 11 | 50736 | 170 | 42570418 |
| Intraocular haematoma | 32.47 | 11.08 | 7 | 50740 | 14 | 42570574 |
| Treatment failure | 32.46 | 11.08 | 17 | 50730 | 62607 | 42507981 |
| Interstitial lung disease | 32.21 | 11.08 | 181 | 50566 | 78281 | 42492307 |
| Exercise lack of | 31.99 | 11.08 | 10 | 50737 | 118 | 42570470 |
| Supravalvular aortic stenosis | 31.27 | 11.08 | 8 | 50739 | 42 | 42570546 |
| Cholestasis | 31.11 | 11.08 | 98 | 50649 | 32781 | 42537807 |
| Abdominal discomfort | 30.49 | 11.08 | 173 | 50574 | 75082 | 42495506 |
| Intestinal atony | 30.37 | 11.08 | 8 | 50739 | 48 | 42570540 |
| Palpitations | 30.01 | 11.08 | 130 | 50617 | 50667 | 42519921 |
| Muscle rupture | 29.59 | 11.08 | 24 | 50723 | 2416 | 42568172 |
| Drug interaction | 29.57 | 11.08 | 464 | 50283 | 266535 | 42304053 |
| Off label use | 29.39 | 11.08 | 560 | 50187 | 637775 | 41932813 |
| Fatigue | 29.16 | 11.08 | 701 | 50046 | 434940 | 42135648 |
| Aorta hypoplasia | 28.81 | 11.08 | 9 | 50738 | 106 | 42570482 |
| Suicide attempt | 27.88 | 11.08 | 10 | 50737 | 46090 | 42524498 |
| Completed suicide | 27.74 | 11.08 | 45 | 50702 | 96420 | 42474168 |
| Disease progression | 27.39 | 11.08 | 84 | 50663 | 143572 | 42427016 |
| Meningitis fungal | 27.09 | 11.08 | 10 | 50737 | 201 | 42570387 |
| Toxicity to various agents | 27.03 | 11.08 | 161 | 50586 | 228975 | 42341613 |
| Diaphragmatic disorder | 26.03 | 11.08 | 17 | 50730 | 1222 | 42569366 |
| Foetal exposure during pregnancy | 25.79 | 11.08 | 12 | 50735 | 47299 | 42523289 |
| Muscle spasms | 25.68 | 11.08 | 183 | 50564 | 85861 | 42484727 |
| Congenital heart valve disorder | 24.94 | 11.08 | 7 | 50740 | 55 | 42570533 |
| Renal-limited thrombotic microangiopathy | 24.55 | 11.08 | 10 | 50737 | 264 | 42570324 |
| Hyperkinetic heart syndrome | 23.84 | 11.08 | 8 | 50739 | 120 | 42570468 |
| Phaeochromocytoma malignant | 23.62 | 11.08 | 7 | 50740 | 68 | 42570520 |
| Arthritis | 23.59 | 11.08 | 106 | 50641 | 41959 | 42528629 |
| Pemphigoid | 23.54 | 11.08 | 46 | 50701 | 11421 | 42559167 |
| Injection site hypersensitivity | 23.40 | 11.08 | 11 | 50736 | 413 | 42570175 |
| Adverse drug reaction | 23.03 | 11.08 | 97 | 50650 | 37337 | 42533251 |
| Sepsis | 22.49 | 11.08 | 142 | 50605 | 199192 | 42371396 |
| Tendon rupture | 22.46 | 11.08 | 37 | 50710 | 8046 | 42562542 |
| Necrotising myositis | 22.39 | 11.08 | 15 | 50732 | 1126 | 42569462 |
| Mitral valve hypoplasia | 22.36 | 11.08 | 6 | 50741 | 39 | 42570549 |
| Coma uraemic | 22.11 | 11.08 | 6 | 50741 | 41 | 42570547 |
| Vascular pseudoaneurysm | 21.55 | 11.08 | 21 | 50726 | 2691 | 42567897 |
| AST/ALT ratio abnormal | 21.29 | 11.08 | 5 | 50742 | 17 | 42570571 |
| Pseudolymphoma | 21.08 | 11.08 | 12 | 50735 | 673 | 42569915 |
| Rash | 21.07 | 11.08 | 454 | 50293 | 276500 | 42294088 |
| Rectal abscess | 21.07 | 11.08 | 17 | 50730 | 1698 | 42568890 |
| Hepatocellular injury | 20.97 | 11.08 | 69 | 50678 | 23609 | 42546979 |
| Nephrogenic anaemia | 20.50 | 11.08 | 20 | 50727 | 2566 | 42568022 |
| Thrombocytopenia | 20.22 | 11.08 | 138 | 50609 | 190141 | 42380447 |
| Pain in extremity | 19.90 | 11.08 | 270 | 50477 | 150334 | 42420254 |
| Multiple organ dysfunction syndrome | 19.75 | 11.08 | 55 | 50692 | 96980 | 42473608 |
| Toxic epidermal necrolysis | 19.56 | 11.08 | 4 | 50743 | 26746 | 42543842 |
| Coarctation of the aorta | 19.29 | 11.08 | 10 | 50737 | 465 | 42570123 |
| Neutropenia | 19.09 | 11.08 | 149 | 50598 | 199282 | 42371306 |
| Chest wall haematoma | 19.01 | 11.08 | 8 | 50739 | 230 | 42570358 |
| Rhabdomyolysis | 18.86 | 11.08 | 158 | 50589 | 77861 | 42492727 |
| Cerebral haematoma | 18.81 | 11.08 | 28 | 50719 | 5582 | 42565006 |
| Neutrophil count decreased | 18.78 | 11.08 | 29 | 50718 | 63386 | 42507202 |
| Congenital aortic anomaly | 18.74 | 11.08 | 6 | 50741 | 77 | 42570511 |
| Intraventricular haemorrhage | 18.52 | 11.08 | 23 | 50724 | 3861 | 42566727 |
| Gait disturbance | 18.41 | 11.08 | 188 | 50559 | 97812 | 42472776 |
| Drug resistance | 18.19 | 11.08 | 9 | 50738 | 34239 | 42536349 |
| Premature baby | 17.92 | 11.08 | 3 | 50744 | 23150 | 42547438 |
| Electrocardiogram ST segment depression | 17.76 | 11.08 | 19 | 50728 | 2718 | 42567870 |
| Left ventricular hypertrophy | 17.47 | 11.08 | 36 | 50711 | 9283 | 42561305 |
| Femoral artery aneurysm | 17.22 | 11.08 | 7 | 50740 | 184 | 42570404 |
| Myelosuppression | 16.89 | 11.08 | 14 | 50733 | 40447 | 42530141 |
| Subdural haematoma | 16.67 | 11.08 | 63 | 50684 | 23075 | 42547513 |
| Toxic optic neuropathy | 16.49 | 11.08 | 12 | 50735 | 1028 | 42569560 |
| Eosinophilic pleural effusion | 16.30 | 11.08 | 8 | 50739 | 331 | 42570257 |
| Carnitine palmitoyltransferase deficiency | 15.96 | 11.08 | 4 | 50743 | 19 | 42570569 |
| Peripheral swelling | 15.93 | 11.08 | 171 | 50576 | 90099 | 42480489 |
| Dependence on oxygen therapy | 15.85 | 11.08 | 7 | 50740 | 227 | 42570361 |
| Agitation | 15.82 | 11.08 | 33 | 50714 | 64281 | 42506307 |
| Lupus-like syndrome | 15.56 | 11.08 | 19 | 50728 | 3135 | 42567453 |
| Injection site discolouration | 15.47 | 11.08 | 15 | 50732 | 1911 | 42568677 |
| Medication error | 15.30 | 11.08 | 79 | 50668 | 33075 | 42537513 |
| Apolipoprotein increased | 15.13 | 11.08 | 3 | 50744 | 3 | 42570585 |
| Infusion related reaction | 15.12 | 11.08 | 31 | 50716 | 60775 | 42509813 |
| Congenital aortic valve stenosis | 15 | 11.08 | 6 | 50741 | 151 | 42570437 |
| Cell death | 14.88 | 11.08 | 18 | 50729 | 2941 | 42567647 |
| Thrombotic stroke | 14.81 | 11.08 | 7 | 50740 | 266 | 42570322 |
| Confusional state | 14.80 | 11.08 | 281 | 50466 | 167316 | 42403272 |
| Haemorrhagic transformation stroke | 14.48 | 11.08 | 14 | 50733 | 1777 | 42568811 |
| Heart transplant rejection | 14.34 | 11.08 | 13 | 50734 | 1521 | 42569067 |
| Intensive care unit acquired weakness | 14.30 | 11.08 | 12 | 50735 | 1266 | 42569322 |
| Weight decreased | 14.26 | 11.08 | 336 | 50411 | 207612 | 42362976 |
| Renal arteriosclerosis | 14.05 | 11.08 | 7 | 50740 | 299 | 42570289 |
| Akinesia | 14.03 | 11.08 | 16 | 50731 | 2456 | 42568132 |
| Hyperkalaemia | 14.00 | 11.08 | 152 | 50595 | 80306 | 42490282 |
| Myotonic dystrophy | 13.96 | 11.08 | 6 | 50741 | 182 | 42570406 |
| Congenital aortic stenosis | 13.91 | 11.08 | 5 | 50742 | 93 | 42570495 |
| Transaminases abnormal | 13.84 | 11.08 | 7 | 50740 | 309 | 42570279 |
| Drug ineffective for unapproved indication | 13.77 | 11.08 | 21 | 50726 | 46142 | 42524446 |
| Therapeutic drug monitoring analysis incorrectly performed | 13.66 | 11.08 | 7 | 50740 | 318 | 42570270 |
| Impatience | 13.62 | 11.08 | 8 | 50739 | 476 | 42570112 |
| Orthostatic tremor | 13.60 | 11.08 | 3 | 50744 | 7 | 42570581 |
| Disseminated mucormycosis | 13.42 | 11.08 | 12 | 50735 | 1379 | 42569209 |
| Sedation | 13.40 | 11.08 | 10 | 50737 | 30465 | 42540123 |
| Anti factor VIII antibody positive | 13.30 | 11.08 | 5 | 50742 | 106 | 42570482 |
| Arteriovenous fistula | 13.27 | 11.08 | 11 | 50736 | 1141 | 42569447 |
| Xerosis | 13.25 | 11.08 | 10 | 50737 | 906 | 42569682 |
| Lip discolouration | 13.24 | 11.08 | 6 | 50741 | 207 | 42570381 |
| Pancytopenia | 13.20 | 11.08 | 84 | 50663 | 117659 | 42452929 |
| Muscle discomfort | 12.97 | 11.08 | 6 | 50741 | 217 | 42570371 |
| Hypoparathyroidism | 12.96 | 11.08 | 9 | 50738 | 716 | 42569872 |
| Diarrhoea | 12.86 | 11.08 | 671 | 50076 | 460178 | 42110410 |
| Myocardial infarction | 12.75 | 11.08 | 213 | 50534 | 123796 | 42446792 |
| General physical health deterioration | 12.67 | 11.08 | 117 | 50630 | 151129 | 42419459 |
| Glycosylated haemoglobin increased | 12.66 | 11.08 | 39 | 50708 | 12885 | 42557703 |
| Loss of personal independence in daily activities | 12.63 | 11.08 | 102 | 50645 | 49714 | 42520874 |
| Bladder cyst | 12.49 | 11.08 | 5 | 50742 | 126 | 42570462 |
| Depression | 12.46 | 11.08 | 194 | 50553 | 111169 | 42459419 |
| Peripheral artery occlusion | 12.42 | 11.08 | 13 | 50734 | 1813 | 42568775 |
| Conjunctival haemorrhage | 12.38 | 11.08 | 18 | 50729 | 3515 | 42567073 |
| Drug eruption | 12.08 | 11.08 | 57 | 50690 | 23018 | 42547570 |
| Pleurisy | 11.82 | 11.08 | 22 | 50725 | 5268 | 42565320 |
| Vomiting | 11.80 | 11.08 | 259 | 50488 | 289464 | 42281124 |
| Acute respiratory failure | 11.79 | 11.08 | 83 | 50664 | 38775 | 42531813 |
| Low density lipoprotein increased | 11.63 | 11.08 | 22 | 50725 | 5333 | 42565255 |
| Heat stroke | 11.58 | 11.08 | 10 | 50737 | 1098 | 42569490 |
| Hepatitis fulminant | 11.55 | 11.08 | 21 | 50726 | 4938 | 42565650 |
| Product container seal issue | 11.53 | 11.08 | 3 | 50744 | 17 | 42570571 |
| Acquired haemophilia | 11.53 | 11.08 | 12 | 50735 | 1663 | 42568925 |
| Ketonuria | 11.31 | 11.08 | 8 | 50739 | 656 | 42569932 |
| Myoglobin urine | 11.25 | 11.08 | 3 | 50744 | 19 | 42570569 |
| Atrial hypertrophy | 11.25 | 11.08 | 3 | 50744 | 19 | 42570569 |
| Heart disease congenital | 11.15 | 11.08 | 11 | 50736 | 1431 | 42569157 |
| Blood urine present | 11.12 | 11.08 | 35 | 50712 | 11698 | 42558890 |
| Blood loss anaemia | 11.09 | 11.08 | 31 | 50716 | 9705 | 42560883 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myalgia | 469.60 | 10.21 | 759 | 96134 | 221622 | 110270784 |
| Acute kidney injury | 273.54 | 10.21 | 1191 | 95702 | 634239 | 109858167 |
| Hand deformity | 176.16 | 10.21 | 3 | 96890 | 218503 | 110273903 |
| Synovitis | 158.83 | 10.21 | 25 | 96868 | 274067 | 110218339 |
| Glossodynia | 141.24 | 10.21 | 15 | 96878 | 221989 | 110270417 |
| Pericarditis | 138.90 | 10.21 | 15 | 96878 | 219099 | 110273307 |
| Infusion related reaction | 138.55 | 10.21 | 81 | 96812 | 381081 | 110111325 |
| Maternal exposure during pregnancy | 131.30 | 10.21 | 31 | 96862 | 254852 | 110237554 |
| Lactic acidosis | 130.74 | 10.21 | 266 | 96627 | 92545 | 110399861 |
| Catarrh | 130.71 | 10.21 | 81 | 96812 | 7254 | 110485152 |
| Duodenal ulcer perforation | 130.27 | 10.21 | 6 | 96887 | 177694 | 110314712 |
| Contraindicated product administered | 128.27 | 10.21 | 30 | 96863 | 248237 | 110244169 |
| Burns second degree | 126.78 | 10.21 | 81 | 96812 | 7652 | 110484754 |
| Helicobacter infection | 124.60 | 10.21 | 9 | 96884 | 181868 | 110310538 |
| Treatment failure | 123.93 | 10.21 | 44 | 96849 | 277190 | 110215216 |
| Fall | 122.47 | 10.21 | 926 | 95967 | 602556 | 109889850 |
| Steroid dependence | 117.67 | 10.21 | 80 | 96813 | 8389 | 110484017 |
| Folliculitis | 115.71 | 10.21 | 8 | 96885 | 167645 | 110324761 |
| Hypopnoea | 111.47 | 10.21 | 87 | 96806 | 11293 | 110481113 |
| Lower respiratory tract infection | 106.26 | 10.21 | 40 | 96853 | 243066 | 110249340 |
| Parosmia | 104.33 | 10.21 | 89 | 96804 | 13091 | 110479315 |
| Wound | 103.43 | 10.21 | 38 | 96855 | 234399 | 110258007 |
| Drug interaction | 102.80 | 10.21 | 770 | 96123 | 499413 | 109992993 |
| Gingival pain | 94.55 | 10.21 | 91 | 96802 | 15645 | 110476761 |
| Drug abuse | 92.50 | 10.21 | 21 | 96872 | 177390 | 110315016 |
| Hyperkalaemia | 92.01 | 10.21 | 295 | 96598 | 135501 | 110356905 |
| Arthropathy | 91.17 | 10.21 | 71 | 96822 | 287451 | 110204955 |
| Drug ineffective | 90.48 | 10.21 | 875 | 96018 | 1519665 | 108972741 |
| Dysgeusia | 88.56 | 10.21 | 192 | 96701 | 69793 | 110422613 |
| Exposure during pregnancy | 86.92 | 10.21 | 20 | 96873 | 167404 | 110325002 |
| Tubulointerstitial nephritis | 86.64 | 10.21 | 164 | 96729 | 54120 | 110438286 |
| Tinnitus | 83.46 | 10.21 | 172 | 96721 | 60368 | 110432038 |
| Eczema | 83.24 | 10.21 | 191 | 96702 | 72102 | 110420304 |
| Blood creatine phosphokinase increased | 79.69 | 10.21 | 189 | 96704 | 72888 | 110419518 |
| Swelling | 79.63 | 10.21 | 115 | 96778 | 350926 | 110141480 |
| Cerebrovascular accident | 79.31 | 10.21 | 342 | 96551 | 180942 | 110311464 |
| Myopathy | 78.52 | 10.21 | 103 | 96790 | 24857 | 110467549 |
| Fibromyalgia | 78.30 | 10.21 | 26 | 96867 | 170883 | 110321523 |
| Alcohol poisoning | 77.79 | 10.21 | 64 | 96829 | 8956 | 110483450 |
| Vertigo | 77.31 | 10.21 | 208 | 96685 | 86662 | 110405744 |
| Bursitis | 77.18 | 10.21 | 11 | 96882 | 129907 | 110362499 |
| IgM nephropathy | 75.51 | 10.21 | 19 | 96874 | 132 | 110492274 |
| Impaired healing | 75.49 | 10.21 | 39 | 96854 | 196678 | 110295728 |
| Joint swelling | 73.10 | 10.21 | 176 | 96717 | 442669 | 110049737 |
| Ill-defined disorder | 71.61 | 10.21 | 24 | 96869 | 156829 | 110335577 |
| Interstitial lung disease | 71.35 | 10.21 | 276 | 96617 | 139058 | 110353348 |
| Nightmare | 70.36 | 10.21 | 124 | 96769 | 38739 | 110453667 |
| Irritable bowel syndrome | 68.50 | 10.21 | 29 | 96864 | 164186 | 110328220 |
| Lip dry | 68.40 | 10.21 | 5 | 96888 | 100078 | 110392328 |
| Rhinitis | 67.79 | 10.21 | 91 | 96802 | 22454 | 110469952 |
| Muscle injury | 67.04 | 10.21 | 20 | 96873 | 140787 | 110351619 |
| Impaired work ability | 65.16 | 10.21 | 97 | 96796 | 26322 | 110466084 |
| Cardiac murmur | 60.14 | 10.21 | 90 | 96803 | 24538 | 110467868 |
| Therapeutic product effect decreased | 59.46 | 10.21 | 76 | 96817 | 244240 | 110248166 |
| Swollen tongue | 59.31 | 10.21 | 150 | 96743 | 60212 | 110432194 |
| Impaired quality of life | 58.56 | 10.21 | 99 | 96794 | 29918 | 110462488 |
| Inflammation | 58.40 | 10.21 | 50 | 96843 | 193188 | 110299218 |
| Cholestasis | 57.93 | 10.21 | 155 | 96738 | 64363 | 110428043 |
| Blister | 57.14 | 10.21 | 69 | 96824 | 227307 | 110265099 |
| Hepatic enzyme increased | 55.77 | 10.21 | 124 | 96769 | 320768 | 110171638 |
| Drug intolerance | 54.87 | 10.21 | 178 | 96715 | 406334 | 110086072 |
| Musculoskeletal stiffness | 54.71 | 10.21 | 101 | 96792 | 279721 | 110212685 |
| Rhabdomyolysis | 54.07 | 10.21 | 229 | 96664 | 120172 | 110372234 |
| Off label use | 52.16 | 10.21 | 964 | 95929 | 1499221 | 108993185 |
| Accidental overdose | 50.08 | 10.21 | 128 | 96765 | 51706 | 110440700 |
| Psoriatic arthropathy | 49.13 | 10.21 | 60 | 96833 | 196701 | 110295705 |
| Lipoprotein (a) decreased | 48.79 | 10.21 | 11 | 96882 | 44 | 110492362 |
| Diarrhoea | 48.67 | 10.21 | 1324 | 95569 | 1138181 | 109354225 |
| Alopecia | 48.33 | 10.21 | 161 | 96732 | 364592 | 110127814 |
| Mobility decreased | 47.93 | 10.21 | 84 | 96809 | 237338 | 110255068 |
| Gastrointestinal disorder | 47.58 | 10.21 | 87 | 96806 | 241865 | 110250541 |
| Injury | 47.57 | 10.21 | 51 | 96842 | 177214 | 110315192 |
| Hyponatraemia | 47.42 | 10.21 | 340 | 96553 | 217313 | 110275093 |
| Chronic kidney disease | 47.42 | 10.21 | 161 | 96732 | 76130 | 110416276 |
| Joint range of motion decreased | 46.96 | 10.21 | 24 | 96869 | 121808 | 110370598 |
| Hypersensitivity | 46.52 | 10.21 | 189 | 96704 | 403809 | 110088597 |
| Liver injury | 45.34 | 10.21 | 39 | 96854 | 150374 | 110342032 |
| Atrial fibrillation | 44.53 | 10.21 | 349 | 96544 | 229293 | 110263113 |
| Systemic lupus erythematosus | 44.41 | 10.21 | 98 | 96795 | 254240 | 110238166 |
| Type 2 diabetes mellitus | 44.30 | 10.21 | 54 | 96839 | 177178 | 110315228 |
| Therapy non-responder | 43.63 | 10.21 | 44 | 96849 | 157263 | 110335143 |
| Red blood cell sedimentation rate increased | 43.43 | 10.21 | 8 | 96885 | 78294 | 110414112 |
| Live birth | 43.40 | 10.21 | 5 | 96888 | 69479 | 110422927 |
| Bronchiectasis | 42.65 | 10.21 | 97 | 96796 | 36396 | 110456010 |
| Infection | 42.61 | 10.21 | 168 | 96725 | 362032 | 110130374 |
| Immune-mediated myositis | 41.43 | 10.21 | 38 | 96855 | 6148 | 110486258 |
| Atrioventricular block second degree | 41.21 | 10.21 | 43 | 96850 | 8138 | 110484268 |
| Wheezing | 40.08 | 10.21 | 104 | 96789 | 255126 | 110237280 |
| Peripheral venous disease | 39.94 | 10.21 | 12 | 96881 | 84105 | 110408301 |
| Hepatocellular injury | 39.88 | 10.21 | 116 | 96777 | 50526 | 110441880 |
| Rheumatoid arthritis | 39.85 | 10.21 | 132 | 96761 | 299481 | 110192925 |
| Pancreatitis acute | 39.05 | 10.21 | 129 | 96764 | 60145 | 110432261 |
| Product dose omission issue | 38.81 | 10.21 | 442 | 96451 | 321340 | 110171066 |
| Pericarditis fungal | 37.40 | 10.21 | 13 | 96880 | 301 | 110492105 |
| Grip strength decreased | 37.06 | 10.21 | 12 | 96881 | 80162 | 110412244 |
| Blepharospasm | 36.75 | 10.21 | 3 | 96890 | 54848 | 110437558 |
| General physical health deterioration | 35.77 | 10.21 | 222 | 96671 | 425073 | 110067333 |
| Myelosuppression | 35.74 | 10.21 | 19 | 96874 | 94321 | 110398085 |
| Discomfort | 35.65 | 10.21 | 85 | 96808 | 214622 | 110277784 |
| Decreased bronchial secretion | 35.59 | 10.21 | 9 | 96884 | 64 | 110492342 |
| Night sweats | 35.45 | 10.21 | 39 | 96854 | 133944 | 110358462 |
| Palpitations | 35.42 | 10.21 | 250 | 96643 | 158962 | 110333444 |
| Congenital coronary artery malformation | 35.10 | 10.21 | 10 | 96883 | 117 | 110492289 |
| Angina pectoris | 34.86 | 10.21 | 127 | 96766 | 62168 | 110430238 |
| Glycosylated haemoglobin increased | 34.80 | 10.21 | 69 | 96824 | 23550 | 110468856 |
| Loss of control of legs | 34.13 | 10.21 | 22 | 96871 | 2110 | 110490296 |
| Muscle spasms | 33.50 | 10.21 | 382 | 96511 | 277775 | 110214631 |
| Pemphigoid | 33.27 | 10.21 | 61 | 96832 | 19646 | 110472760 |
| Muscle rupture | 33.04 | 10.21 | 29 | 96864 | 4431 | 110487975 |
| Blood glucose increased | 33.03 | 10.21 | 214 | 96679 | 132282 | 110360124 |
| Gastritis fungal | 33.00 | 10.21 | 12 | 96881 | 318 | 110492088 |
| Full blood count decreased | 32.82 | 10.21 | 81 | 96812 | 32018 | 110460388 |
| Colitis microscopic | 32.78 | 10.21 | 49 | 96844 | 13345 | 110479061 |
| Cerebral haematoma | 32.25 | 10.21 | 41 | 96852 | 9591 | 110482815 |
| Suicide attempt | 32.16 | 10.21 | 26 | 96867 | 103368 | 110389038 |
| Intraocular haematoma | 32.12 | 10.21 | 7 | 96886 | 23 | 110492383 |
| Amaurosis fugax | 31.84 | 10.21 | 22 | 96871 | 2368 | 110490038 |
| Wound infection | 31.60 | 10.21 | 23 | 96870 | 96442 | 110395964 |
| COVID-19 | 31.54 | 10.21 | 341 | 96552 | 244719 | 110247687 |
| Puncture site haematoma | 31.31 | 10.21 | 11 | 96882 | 263 | 110492143 |
| Subdural haematoma | 31.14 | 10.21 | 86 | 96807 | 36368 | 110456038 |
| Blood thyroid stimulating hormone normal | 30.79 | 10.21 | 9 | 96884 | 116 | 110492290 |
| Pain in extremity | 30.65 | 10.21 | 598 | 96295 | 486520 | 110005886 |
| Pulmonary fibrosis | 30.10 | 10.21 | 27 | 96866 | 102015 | 110390391 |
| Bone erosion | 29.82 | 10.21 | 3 | 96890 | 46368 | 110446038 |
| Product use issue | 29.81 | 10.21 | 156 | 96737 | 311539 | 110180867 |
| Cardiac failure congestive | 29.54 | 10.21 | 230 | 96663 | 150770 | 110341636 |
| Blood loss anaemia | 29.43 | 10.21 | 55 | 96838 | 17970 | 110474436 |
| Completed suicide | 29.40 | 10.21 | 111 | 96782 | 242270 | 110250136 |
| Haemorrhagic stroke | 28.94 | 10.21 | 47 | 96846 | 13742 | 110478664 |
| Haematoma | 28.43 | 10.21 | 114 | 96779 | 58362 | 110434044 |
| Febrile neutropenia | 28.39 | 10.21 | 162 | 96731 | 316605 | 110175801 |
| Pseudolymphoma | 28.18 | 10.21 | 16 | 96877 | 1219 | 110491187 |
| Sinusitis | 28.09 | 10.21 | 149 | 96744 | 296539 | 110195867 |
| Death | 26.93 | 10.21 | 802 | 96091 | 698067 | 109794339 |
| Obesity | 26.80 | 10.21 | 36 | 96857 | 113315 | 110379091 |
| Cerebral infarction | 26.77 | 10.21 | 103 | 96790 | 51735 | 110440671 |
| Autoimmune disorder | 26.61 | 10.21 | 12 | 96881 | 65471 | 110426935 |
| Sciatica | 26.60 | 10.21 | 25 | 96868 | 92374 | 110400032 |
| Stomatitis | 26.55 | 10.21 | 134 | 96759 | 270108 | 110222298 |
| Phaeochromocytoma malignant | 25.75 | 10.21 | 7 | 96886 | 68 | 110492338 |
| C-reactive protein increased | 25.66 | 10.21 | 101 | 96792 | 217818 | 110274588 |
| Shone complex | 25.52 | 10.21 | 6 | 96887 | 30 | 110492376 |
| Mitral valve hypoplasia | 25.52 | 10.21 | 6 | 96887 | 30 | 110492376 |
| Meningitis fungal | 25.46 | 10.21 | 10 | 96883 | 329 | 110492077 |
| Congenital aortic valve stenosis | 25.36 | 10.21 | 6 | 96887 | 31 | 110492375 |
| Hyperkinetic heart syndrome | 25.11 | 10.21 | 8 | 96885 | 140 | 110492266 |
| Gait disturbance | 24.99 | 10.21 | 362 | 96531 | 277846 | 110214560 |
| Aorta hypoplasia | 24.89 | 10.21 | 6 | 96887 | 34 | 110492372 |
| Urinary tract infection | 24.53 | 10.21 | 412 | 96481 | 325870 | 110166536 |
| Intraventricular haemorrhage | 24.32 | 10.21 | 27 | 96866 | 5480 | 110486926 |
| Diaphragmatic disorder | 24.28 | 10.21 | 17 | 96876 | 1869 | 110490537 |
| Rectal haemorrhage | 24.26 | 10.21 | 184 | 96709 | 119649 | 110372757 |
| Metabolic acidosis | 24.18 | 10.21 | 160 | 96733 | 99584 | 110392822 |
| Vaccination site pain | 24.10 | 10.21 | 11 | 96882 | 528 | 110491878 |
| Congenital heart valve disorder | 24.06 | 10.21 | 6 | 96887 | 40 | 110492366 |
| Coma uraemic | 23.81 | 10.21 | 6 | 96887 | 42 | 110492364 |
| Toxicity to various agents | 23.38 | 10.21 | 289 | 96604 | 480266 | 110012140 |
| BRASH syndrome | 23.26 | 10.21 | 22 | 96871 | 3701 | 110488705 |
| Heart transplant rejection | 23.22 | 10.21 | 17 | 96876 | 2004 | 110490402 |
| Foot deformity | 22.86 | 10.21 | 7 | 96886 | 48473 | 110443933 |
| Allergic sinusitis | 22.80 | 10.21 | 16 | 96877 | 1765 | 110490641 |
| Dermatitis atopic | 22.56 | 10.21 | 61 | 96832 | 25480 | 110466926 |
| Therapeutic product effect incomplete | 21.96 | 10.21 | 111 | 96782 | 223694 | 110268712 |
| Myocardial infarction | 21.87 | 10.21 | 261 | 96632 | 191822 | 110300584 |
| Tendon rupture | 21.80 | 10.21 | 42 | 96851 | 14036 | 110478370 |
| Bezoar | 21.67 | 10.21 | 22 | 96871 | 4032 | 110488374 |
| Intestinal atony | 21.35 | 10.21 | 8 | 96885 | 231 | 110492175 |
| Congenital aortic stenosis | 21.27 | 10.21 | 5 | 96888 | 25 | 110492381 |
| Congenital aortic anomaly | 21.27 | 10.21 | 5 | 96888 | 25 | 110492381 |
| Exercise lack of | 21.25 | 10.21 | 10 | 96883 | 515 | 110491891 |
| Pulseless electrical activity | 21.22 | 10.21 | 46 | 96847 | 16711 | 110475695 |
| Loss of consciousness | 21.16 | 10.21 | 264 | 96629 | 196042 | 110296364 |
| Coarctation of the aorta | 21.15 | 10.21 | 6 | 96887 | 69 | 110492337 |
| Insulin autoimmune syndrome | 20.76 | 10.21 | 11 | 96882 | 731 | 110491675 |
| Supravalvular aortic stenosis | 20.65 | 10.21 | 5 | 96888 | 29 | 110492377 |
| Epilepsy | 20.62 | 10.21 | 35 | 96858 | 100174 | 110392232 |
| Deep vein thrombosis | 20.53 | 10.21 | 200 | 96693 | 139687 | 110352719 |
| Hepatic cytolysis | 20.43 | 10.21 | 99 | 96794 | 54954 | 110437452 |
| Melaena | 20.26 | 10.21 | 116 | 96777 | 68641 | 110423765 |
| Drug ineffective for unapproved indication | 20.19 | 10.21 | 37 | 96856 | 102801 | 110389605 |
| Cerebral haemorrhage | 20.07 | 10.21 | 111 | 96782 | 64857 | 110427549 |
| Weight decreased | 19.90 | 10.21 | 544 | 96349 | 467513 | 110024893 |
| Inappropriate antidiuretic hormone secretion | 19.78 | 10.21 | 70 | 96823 | 33781 | 110458625 |
| Diabetic ketoacidosis | 19.66 | 10.21 | 81 | 96812 | 41977 | 110450429 |
| Myositis | 19.62 | 10.21 | 66 | 96827 | 31050 | 110461356 |
| Transient ischaemic attack | 19.55 | 10.21 | 109 | 96784 | 63873 | 110428533 |
| Toxic optic neuropathy | 19.54 | 10.21 | 13 | 96880 | 1315 | 110491091 |
| Prescribed overdose | 19.53 | 10.21 | 29 | 96864 | 87552 | 110404854 |
| Haematuria | 19.43 | 10.21 | 132 | 96761 | 82873 | 110409533 |
| Hypercholesterolaemia | 19.37 | 10.21 | 31 | 96862 | 90806 | 110401600 |
| Polymyalgia rheumatica | 19.36 | 10.21 | 26 | 96867 | 6416 | 110485990 |
| Vascular pseudoaneurysm | 19.30 | 10.21 | 21 | 96872 | 4169 | 110488237 |
| Glycosuria | 19.28 | 10.21 | 17 | 96876 | 2613 | 110489793 |
| Low density lipoprotein increased | 19.26 | 10.21 | 34 | 96859 | 10632 | 110481774 |
| Renal failure | 19.24 | 10.21 | 292 | 96601 | 226282 | 110266124 |
| Dry mouth | 19.15 | 10.21 | 100 | 96793 | 199848 | 110292558 |
| Coeliac disease | 19.03 | 10.21 | 7 | 96886 | 43180 | 110449226 |
| Acute respiratory failure | 19.02 | 10.21 | 122 | 96771 | 75138 | 110417268 |
| Restless legs syndrome | 18.99 | 10.21 | 56 | 96837 | 24570 | 110467836 |
| Rectal abscess | 18.92 | 10.21 | 17 | 96876 | 2679 | 110489727 |
| Left ventricular failure | 18.90 | 10.21 | 35 | 96858 | 11354 | 110481052 |
| Back injury | 18.77 | 10.21 | 9 | 96884 | 47390 | 110445016 |
| Hip arthroplasty | 18.68 | 10.21 | 13 | 96880 | 55800 | 110436606 |
| Hepatitis cholestatic | 18.68 | 10.21 | 45 | 96848 | 17521 | 110474885 |
| Acute interstitial pneumonitis | 18.54 | 10.21 | 13 | 96880 | 1433 | 110490973 |
| Femoral artery aneurysm | 18.19 | 10.21 | 7 | 96886 | 218 | 110492188 |
| Toxic epidermal necrolysis | 17.97 | 10.21 | 14 | 96879 | 56713 | 110435693 |
| Syncope | 17.97 | 10.21 | 263 | 96630 | 202273 | 110290133 |
| Atrioventricular block first degree | 17.96 | 10.21 | 39 | 96854 | 14186 | 110478220 |
| Eosinophilia | 17.90 | 10.21 | 99 | 96794 | 57837 | 110434569 |
| Electrocardiogram ST segment depression | 17.90 | 10.21 | 23 | 96870 | 5438 | 110486968 |
| Renal-limited thrombotic microangiopathy | 17.86 | 10.21 | 9 | 96884 | 539 | 110491867 |
| Hypokalaemia | 17.83 | 10.21 | 241 | 96652 | 182207 | 110310199 |
| Ocular discomfort | 17.79 | 10.21 | 29 | 96864 | 8504 | 110483902 |
| Feeling abnormal | 17.78 | 10.21 | 239 | 96654 | 180472 | 110311934 |
| Lower limb fracture | 17.74 | 10.21 | 24 | 96869 | 75324 | 110417082 |
| Sedation | 17.65 | 10.21 | 21 | 96872 | 69662 | 110422744 |
| Carnitine palmitoyltransferase deficiency | 17.36 | 10.21 | 4 | 96889 | 18 | 110492388 |
| Asthenia | 17.23 | 10.21 | 753 | 96140 | 688246 | 109804160 |
| Haemorrhagic transformation stroke | 17.19 | 10.21 | 17 | 96876 | 3020 | 110489386 |
| Vitamin B12 decreased | 17.01 | 10.21 | 22 | 96871 | 5235 | 110487171 |
| Renal disorder | 16.96 | 10.21 | 87 | 96806 | 49392 | 110443014 |
| Corneal dystrophy | 16.92 | 10.21 | 7 | 96886 | 264 | 110492142 |
| Therapy cessation | 16.89 | 10.21 | 81 | 96812 | 44776 | 110447630 |
| International normalised ratio increased | 16.87 | 10.21 | 132 | 96761 | 86640 | 110405766 |
| Hospice care | 16.67 | 10.21 | 35 | 96858 | 12438 | 110479968 |
| Intentional self-injury | 16.61 | 10.21 | 6 | 96887 | 37423 | 110454983 |
| Post viral fatigue syndrome | 16.56 | 10.21 | 7 | 96886 | 279 | 110492127 |
| Fatigue | 16.48 | 10.21 | 1257 | 95636 | 1214701 | 109277705 |
| Mixed liver injury | 16.27 | 10.21 | 34 | 96859 | 12045 | 110480361 |
| Heart disease congenital | 16.26 | 10.21 | 9 | 96884 | 653 | 110491753 |
| Coronary artery disease | 16.18 | 10.21 | 113 | 96780 | 71577 | 110420829 |
| Somnolence | 16.01 | 10.21 | 357 | 96536 | 297092 | 110195314 |
| Vision blurred | 15.88 | 10.21 | 178 | 96715 | 128844 | 110363562 |
| Foreign body sensation in eyes | 15.86 | 10.21 | 17 | 96876 | 3317 | 110489089 |
| Sinus arrhythmia | 15.85 | 10.21 | 14 | 96879 | 2156 | 110490250 |
| Onychomycosis | 15.75 | 10.21 | 7 | 96886 | 38524 | 110453882 |
| Patent ductus arteriosus | 15.71 | 10.21 | 6 | 96887 | 183 | 110492223 |
| Osteoporosis | 15.68 | 10.21 | 33 | 96860 | 87119 | 110405287 |
| Epistaxis | 15.66 | 10.21 | 179 | 96714 | 130193 | 110362213 |
| Alexithymia | 15.51 | 10.21 | 4 | 96889 | 31 | 110492375 |
| Device expulsion | 15.42 | 10.21 | 4 | 96889 | 30887 | 110461519 |
| Myotonic dystrophy | 15.41 | 10.21 | 6 | 96887 | 193 | 110492213 |
| Haemorrhage intracranial | 15.32 | 10.21 | 58 | 96835 | 28911 | 110463495 |
| Eosinophilic pleural effusion | 15.27 | 10.21 | 8 | 96885 | 520 | 110491886 |
| Finger deformity | 15.21 | 10.21 | 5 | 96888 | 33087 | 110459319 |
| Behaviour disorder | 15.21 | 10.21 | 29 | 96864 | 9618 | 110482788 |
| Lower gastrointestinal haemorrhage | 15.19 | 10.21 | 43 | 96850 | 18443 | 110473963 |
| Chest wall haematoma | 15.17 | 10.21 | 8 | 96885 | 527 | 110491879 |
| Axonal neuropathy | 15.06 | 10.21 | 14 | 96879 | 2304 | 110490102 |
| Head injury | 15 | 10.21 | 76 | 96817 | 42941 | 110449465 |
| Cough | 14.94 | 10.21 | 519 | 96374 | 461122 | 110031284 |
| Myopathy toxic | 14.90 | 10.21 | 11 | 96882 | 1314 | 110491092 |
| Anti factor VIII antibody positive | 14.89 | 10.21 | 5 | 96888 | 104 | 110492302 |
| Inappropriate schedule of product administration | 14.88 | 10.21 | 256 | 96637 | 203381 | 110289025 |
| Drug tolerance decreased | 14.88 | 10.21 | 3 | 96890 | 27537 | 110464869 |
| Necrotising myositis | 14.79 | 10.21 | 13 | 96880 | 1989 | 110490417 |
| Cardiac murmur functional | 14.70 | 10.21 | 4 | 96889 | 39 | 110492367 |
| Peptic ulcer | 14.69 | 10.21 | 25 | 96868 | 7594 | 110484812 |
| Gastrointestinal haemorrhage | 14.31 | 10.21 | 214 | 96679 | 165304 | 110327102 |
| Bradycardia | 14.21 | 10.21 | 203 | 96690 | 155314 | 110337092 |
| Anaemia | 14.13 | 10.21 | 600 | 96293 | 546486 | 109945920 |
| Squamous cell carcinoma of skin | 14.12 | 10.21 | 40 | 96853 | 17163 | 110475243 |
| Erythematotelangiectatic rosacea | 13.99 | 10.21 | 5 | 96888 | 126 | 110492280 |
| Cholestatic liver injury | 13.95 | 10.21 | 24 | 96869 | 7352 | 110485054 |
| Acute myocardial infarction | 13.91 | 10.21 | 123 | 96770 | 83654 | 110408752 |
| Mouth ulceration | 13.88 | 10.21 | 13 | 96880 | 48125 | 110444281 |
| Speech disorder | 13.87 | 10.21 | 97 | 96796 | 61472 | 110430934 |
| Dizziness | 13.86 | 10.21 | 746 | 96147 | 697447 | 109794959 |
| Pancreatic steatosis | 13.80 | 10.21 | 12 | 96881 | 1810 | 110490596 |
| Arteriovenous fistula | 13.78 | 10.21 | 11 | 96882 | 1474 | 110490932 |
| Back pain | 13.78 | 10.21 | 424 | 96469 | 370572 | 110121834 |
| Stress | 13.73 | 10.21 | 147 | 96746 | 105201 | 110387205 |
| Synovial disorder | 13.73 | 10.21 | 15 | 96878 | 2992 | 110489414 |
| Hypersensitivity vasculitis | 13.69 | 10.21 | 23 | 96870 | 6914 | 110485492 |
| Electrocardiogram PR prolongation | 13.68 | 10.21 | 12 | 96881 | 1831 | 110490575 |
| Bladder cyst | 13.59 | 10.21 | 5 | 96888 | 137 | 110492269 |
| Acquired haemophilia | 13.56 | 10.21 | 14 | 96879 | 2617 | 110489789 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 13.52 | 10.21 | 20 | 96873 | 5397 | 110487009 |
| Dehydration | 13.36 | 10.21 | 330 | 96563 | 279181 | 110213225 |
| Atrial hypertrophy | 13.32 | 10.21 | 4 | 96889 | 57 | 110492349 |
| Subacute cutaneous lupus erythematosus | 13.28 | 10.21 | 19 | 96874 | 4975 | 110487431 |
| Ligament rupture | 13.23 | 10.21 | 17 | 96876 | 4018 | 110488388 |
| AST/ALT ratio abnormal | 13.23 | 10.21 | 5 | 96888 | 148 | 110492258 |
| Drug resistance | 13.23 | 10.21 | 18 | 96875 | 56356 | 110436050 |
| Erectile dysfunction | 13.19 | 10.21 | 41 | 96852 | 18515 | 110473891 |
| Knee arthroplasty | 13.08 | 10.21 | 23 | 96870 | 64925 | 110427481 |
| Urinary incontinence | 13.05 | 10.21 | 80 | 96813 | 48507 | 110443899 |
| Eye irritation | 13.03 | 10.21 | 61 | 96832 | 33391 | 110459015 |
| Electrocardiogram abnormal | 12.98 | 10.21 | 41 | 96852 | 18668 | 110473738 |
| Akinesia | 12.90 | 10.21 | 16 | 96877 | 3651 | 110488755 |
| Ligament sprain | 12.83 | 10.21 | 37 | 96856 | 16031 | 110476375 |
| Blood triglycerides increased | 12.73 | 10.21 | 48 | 96845 | 23878 | 110468528 |
| Blood glucose abnormal | 12.58 | 10.21 | 32 | 96861 | 12884 | 110479522 |
| Vessel puncture site bruise | 12.56 | 10.21 | 7 | 96886 | 515 | 110491891 |
| Diplopia | 12.55 | 10.21 | 71 | 96822 | 41823 | 110450583 |
| Muscle haemorrhage | 12.54 | 10.21 | 22 | 96871 | 6847 | 110485559 |
| Renal arteriosclerosis | 12.53 | 10.21 | 7 | 96886 | 517 | 110491889 |
| Nasopharyngitis | 12.50 | 10.21 | 257 | 96636 | 394104 | 110098302 |
| Gastric infection | 12.49 | 10.21 | 17 | 96876 | 4249 | 110488157 |
| Diabetic wound | 12.40 | 10.21 | 4 | 96889 | 73 | 110492333 |
| Dry gangrene | 12.34 | 10.21 | 9 | 96884 | 1055 | 110491351 |
| Cardiac failure | 12.34 | 10.21 | 232 | 96661 | 187394 | 110305012 |
| Disseminated mucormycosis | 12.33 | 10.21 | 12 | 96881 | 2090 | 110490316 |
| Mucosal inflammation | 12.33 | 10.21 | 43 | 96850 | 96098 | 110396308 |
| Thrombotic stroke | 12.29 | 10.21 | 8 | 96885 | 780 | 110491626 |
| Muscle strain | 12.24 | 10.21 | 29 | 96864 | 11173 | 110481233 |
| Nail disorder | 12.14 | 10.21 | 20 | 96873 | 57915 | 110434491 |
| Hypoxic-ischaemic encephalopathy | 12.03 | 10.21 | 25 | 96868 | 8822 | 110483584 |
| Mammogram abnormal | 12.00 | 10.21 | 7 | 96886 | 561 | 110491845 |
| Bacteriuria | 11.98 | 10.21 | 10 | 96883 | 1428 | 110490978 |
| Prostate cancer metastatic | 11.98 | 10.21 | 18 | 96875 | 4925 | 110487481 |
| Hyperlactacidaemia | 11.96 | 10.21 | 24 | 96869 | 8262 | 110484144 |
| Thyroiditis | 11.93 | 10.21 | 21 | 96872 | 6552 | 110485854 |
| Appendicitis | 11.91 | 10.21 | 5 | 96888 | 28459 | 110463947 |
| Uterine dilation and evacuation | 11.90 | 10.21 | 3 | 96890 | 21 | 110492385 |
| Tendon disorder | 11.86 | 10.21 | 24 | 96869 | 8313 | 110484093 |
| Liver function test increased | 11.77 | 10.21 | 39 | 96854 | 88509 | 110403897 |
| Intentional overdose | 11.73 | 10.21 | 68 | 96825 | 132433 | 110359973 |
| Dystonia | 11.68 | 10.21 | 4 | 96889 | 25801 | 110466605 |
| Pyuria | 11.66 | 10.21 | 13 | 96880 | 2650 | 110489756 |
| Sinus node dysfunction | 11.65 | 10.21 | 25 | 96868 | 9022 | 110483384 |
| Sopor | 11.60 | 10.21 | 9 | 96884 | 36537 | 110455869 |
| Adenocarcinoma of appendix | 11.57 | 10.21 | 4 | 96889 | 91 | 110492315 |
| Haematoma muscle | 11.52 | 10.21 | 16 | 96877 | 4074 | 110488332 |
| Feeling hot | 11.52 | 10.21 | 41 | 96852 | 91065 | 110401341 |
| Exostosis | 11.48 | 10.21 | 14 | 96879 | 45942 | 110446464 |
| Scratch | 11.46 | 10.21 | 31 | 96862 | 12948 | 110479458 |
| Renal tubular necrosis | 11.45 | 10.21 | 55 | 96838 | 30420 | 110461986 |
| Hypoparathyroidism | 11.44 | 10.21 | 10 | 96883 | 1520 | 110490886 |
| Postictal paralysis | 11.43 | 10.21 | 7 | 96886 | 614 | 110491792 |
| Decreased appetite | 11.42 | 10.21 | 518 | 96375 | 475328 | 110017078 |
| Sleep disorder | 11.41 | 10.21 | 115 | 96778 | 198529 | 110293877 |
| Adenocarcinoma metastatic | 11.39 | 10.21 | 6 | 96887 | 394 | 110492012 |
| Large intestine polyp | 11.30 | 10.21 | 34 | 96859 | 15083 | 110477323 |
| Plasma cell myeloma | 11.29 | 10.21 | 94 | 96799 | 62842 | 110429564 |
| Heat stroke | 11.27 | 10.21 | 11 | 96882 | 1924 | 110490482 |
| Pericardial haemorrhage | 11.24 | 10.21 | 18 | 96875 | 5199 | 110487207 |
| Immunosuppressant drug level decreased | 11.24 | 10.21 | 13 | 96880 | 2758 | 110489648 |
| Hypoglycaemia | 11.19 | 10.21 | 153 | 96740 | 115951 | 110376455 |
| Anti factor X activity increased | 11.18 | 10.21 | 4 | 96889 | 101 | 110492305 |
| Iron deficiency anaemia | 11.17 | 10.21 | 56 | 96837 | 31503 | 110460903 |
| Intensive care unit acquired weakness | 11.17 | 10.21 | 12 | 96881 | 2347 | 110490059 |
| Cell death | 11.16 | 10.21 | 19 | 96874 | 5772 | 110486634 |
| Fixed eruption | 11.10 | 10.21 | 16 | 96877 | 4216 | 110488190 |
| Hypovolaemic shock | 11.09 | 10.21 | 33 | 96860 | 14550 | 110477856 |
| Urinary tract disorder | 11.04 | 10.21 | 19 | 96874 | 5825 | 110486581 |
| Symptom recurrence | 11.03 | 10.21 | 17 | 96876 | 4755 | 110487651 |
| Blood cholesterol increased | 11.02 | 10.21 | 106 | 96787 | 184679 | 110307727 |
| Heart transplant | 10.90 | 10.21 | 10 | 96883 | 1618 | 110490788 |
| Dermatitis bullous | 10.89 | 10.21 | 37 | 96856 | 17492 | 110474914 |
| Brain herniation | 10.85 | 10.21 | 24 | 96869 | 8839 | 110483567 |
| Peak expiratory flow rate abnormal | 10.79 | 10.21 | 4 | 96889 | 112 | 110492294 |
| Xerosis | 10.79 | 10.21 | 10 | 96883 | 1639 | 110490767 |
| Poor dental condition | 10.78 | 10.21 | 7 | 96886 | 680 | 110491726 |
| Pre-existing condition improved | 10.76 | 10.21 | 20 | 96873 | 6506 | 110485900 |
| Pleurisy | 10.76 | 10.21 | 29 | 96864 | 12087 | 110480319 |
| Eye pain | 10.74 | 10.21 | 78 | 96815 | 50021 | 110442385 |
| Transaminases abnormal | 10.66 | 10.21 | 8 | 96885 | 980 | 110491426 |
| Splenic vein thrombosis | 10.61 | 10.21 | 8 | 96885 | 987 | 110491419 |
| Oropharyngeal pain | 10.59 | 10.21 | 172 | 96721 | 135104 | 110357302 |
| Schizophrenia | 10.57 | 10.21 | 3 | 96890 | 21823 | 110470583 |
| Therapeutic drug monitoring analysis incorrectly performed | 10.55 | 10.21 | 7 | 96886 | 705 | 110491701 |
| Conjunctival haemorrhage | 10.53 | 10.21 | 20 | 96873 | 6613 | 110485793 |
| Human ehrlichiosis | 10.52 | 10.21 | 7 | 96886 | 708 | 110491698 |
| Eosinophilic pneumonia | 10.51 | 10.21 | 21 | 96872 | 7206 | 110485200 |
| Dyspnoea | 10.48 | 10.21 | 1115 | 95778 | 1105757 | 109386649 |
| Essential hypertension | 10.47 | 10.21 | 22 | 96871 | 7825 | 110484581 |
| Muscle discomfort | 10.44 | 10.21 | 6 | 96887 | 468 | 110491938 |
| Neurotoxicity | 10.39 | 10.21 | 13 | 96880 | 42194 | 110450212 |
| Cutaneous lupus erythematosus | 10.36 | 10.21 | 14 | 96879 | 3474 | 110488932 |
| Eye haemorrhage | 10.28 | 10.21 | 28 | 96865 | 11746 | 110480660 |
| Hepatitis fulminant | 10.28 | 10.21 | 23 | 96870 | 8537 | 110483869 |
| Instillation site pain | 10.25 | 10.21 | 7 | 96886 | 739 | 110491667 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C10AA03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
| ATC | C10BA03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
| ATC | C10BA11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
| ATC | C10BA12 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
| ATC | C10BX02 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
| FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
| MeSH PA | D000924 | Anticholesteremic Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| MeSH PA | D057847 | Lipid Regulating Agents |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:145947 | antiatherosclerotic agent |
| CHEBI has role | CHEBI:25212 | metabolite |
| CHEBI has role | CHEBI:33231 | antitubercular agent |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
| CHEBI has role | CHEBI:233423 | antifibrotic agent |
Related Drugs by ATC class:
C10AA HMG CoA reductase inhibitors 7 drugs
C10BA Combinations of various lipid modifying agents 9 drugs
C10BX Lipid modifying agents in combination with other drugs 14 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypercholesterolemia | indication | 13644009 | |
| Arteriosclerotic vascular disease | indication | 72092001 | |
| Cerebrovascular accident | indication | 230690007 | |
| Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
| Mixed hyperlipidemia | indication | 267434003 | |
| Hypertriglyceridemia | indication | 302870006 | |
| Familial type 3 hyperlipoproteinemia | indication | 398796005 | DOID:3145 |
| Primary Prevention of Coronary Heart Disease | indication | ||
| Prevention of Transient Ischemic Attacks | indication | ||
| Myocardial Infarction Prevention | indication | ||
| Slow Progression of Coronary Artery Disease | indication | ||
| Alcoholism | contraindication | 7200002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Sarcoidosis | contraindication | 31541009 | DOID:11335 |
| Dehydration | contraindication | 34095006 | |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Low blood pressure | contraindication | 45007003 | |
| Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
| Nasal polyp | contraindication | 52756005 | |
| Acute nephropathy | contraindication | 58574008 | |
| Diarrhea | contraindication | 62315008 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Factor II deficiency | contraindication | 73975000 | |
| Reye's syndrome | contraindication | 74351001 | DOID:14525 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Hemophilia | contraindication | 90935002 | |
| Kidney stone | contraindication | 95570007 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
| Disorder of muscle | contraindication | 129565002 | DOID:423 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Osteolysis | contraindication | 203522001 | |
| Hemorrhagic cerebral infarction | contraindication | 230706003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Rhabdomyolysis | contraindication | 240131006 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Surgical procedure | contraindication | 387713003 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Traumatic injury | contraindication | 417746004 | |
| Acute erosive gastritis | contraindication | 444926003 | |
| Uncontrolled Epilepsy | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.44 | acidic |
| pKa2 | 13.74 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | IC50 | 7.52 | CHEMBL | CHEMBL | |||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.38 | CHEMBL | |||||
| Solute carrier family 22 member 6 | Transporter | Ki | 4.28 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020548 | VUID |
| N0000148255 | NUI |
| D00893 | KEGG_DRUG |
| 81131-70-6 | SECONDARY_CAS_RN |
| 4020369 | VANDF |
| 4020548 | VANDF |
| C0085542 | UMLSCUI |
| CHEBI:63618 | CHEBI |
| CHEMBL1144 | ChEMBL_ID |
| CHEMBL690 | ChEMBL_ID |
| D017035 | MESH_DESCRIPTOR_UI |
| DB00175 | DRUGBANK_ID |
| 54687 | PUBCHEM_CID |
| 2953 | IUPHAR_LIGAND_ID |
| 6070 | INN_ID |
| KXO2KT9N0G | UNII |
| 203144 | RXNORM |
| 1884 | MMSL |
| 5343 | MMSL |
| 81574 | MMSL |
| d00348 | MMSL |
| 003606 | NDDF |
| 003607 | NDDF |
| 373566006 | SNOMEDCT_US |
| 96305006 | SNOMEDCT_US |
| 96306007 | SNOMEDCT_US |
| KXO2KT9N0G | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0771 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7201 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7202 | TABLET | 40 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-7270 | TABLET | 80 mg | ORAL | ANDA | 25 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8539 | TABLET | 10 mg | ORAL | ANDA | 30 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8540 | TABLET | 20 mg | ORAL | ANDA | 30 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8541 | TABLET | 40 mg | ORAL | ANDA | 30 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8542 | TABLET | 80 mg | ORAL | ANDA | 30 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8618 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8619 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8620 | TABLET | 40 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8621 | TABLET | 80 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5891 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5892 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5893 | TABLET | 40 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-440 | TABLET | 10 mg | ORAL | ANDA | 27 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-505 | TABLET | 20 mg | ORAL | ANDA | 27 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-507 | TABLET | 40 mg | ORAL | ANDA | 27 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-558 | TABLET | 10 mg | ORAL | ANDA | 25 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-559 | TABLET | 20 mg | ORAL | ANDA | 25 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-560 | TABLET | 40 mg | ORAL | ANDA | 25 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-570 | TABLET | 80 mg | ORAL | ANDA | 25 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-008 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-009 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-010 | TABLET | 40 mg | ORAL | ANDA | 24 sections |
| PRAVASTATIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-011 | TABLET | 80 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-178 | TABLET | 10 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-179 | TABLET | 20 mg | ORAL | ANDA | 24 sections |
| Pravastatin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-180 | TABLET | 40 mg | ORAL | ANDA | 24 sections |
| pravastatin sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-867 | TABLET | 20 mg | ORAL | ANDA | 26 sections |