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phenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4266 | 108-95-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antiseptic and disinfectant aromatic alcohol.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 15.40 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 | 51 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,ERBB2,GRK2,MAP3K21,MAPK7,MARK4,PDK4,PIK3CD,SIK2,SIK3,STK33,TTK | 20 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cystitis-like symptom | 26.17 | 22.24 | 3 | 1356 | 9 | 90627079 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product packaging confusion | 36.11 | 28.05 | 5 | 483 | 113 | 42620734 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product packaging confusion | 28.74 | 21.06 | 5 | 1668 | 384 | 110587242 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05BB05 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Sclerosing agents for local injection |
| ATC | D08AE03 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Phenol and derivatives |
| ATC | N01BX03 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Other local anesthetics |
| ATC | R02AA19 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:48218 | antiseptic drug |
| CHEBI has role | CHEBI:48219 | disinfectant |
| CHEBI has role | CHEBI:64952 | anti-HSV agent |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:76967 | human xenobiotic metabolite |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004202 | Disinfectants |
| MeSH PA | D012597 | Sclerosing Solutions |
Related Drugs by ATC class:
C05BB Sclerosing agents for local injection 4 drugs
D08AE Phenol and derivatives 5 drugs
N01BX Other local anesthetics 3 drugs
R02AA Antiseptics 15 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Skin irritation | indication | 367466007 | |
| Itching of skin | indication | 418363000 | |
| Minor Skin Wound Pain | indication | ||
| Mouth Irritation | indication | ||
| Herpes zoster | contraindication | 4740000 | DOID:8536 |
| Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
| Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
| Progressive multifocal leukoencephalopathy | contraindication | 22255007 | DOID:643 |
| Shock | contraindication | 27942005 | |
| Cytomegalovirus infection | contraindication | 28944009 | |
| Constitutional aplastic anemia | contraindication | 28975000 | DOID:1342 |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Gastrointestinal perforation | contraindication | 51875005 | |
| Acute nephropathy | contraindication | 58574008 | |
| Acute infectious disease | contraindication | 63171007 | |
| Incontinence of feces | contraindication | 72042002 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Malignant lymphoma | contraindication | 118600007 | DOID:0060058 |
| Deficiency of hypoxanthine phosphoribosyltransferase | contraindication | 124275001 | |
| Open wound | contraindication | 125643001 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Seizure disorder | contraindication | 128613002 | |
| Heart block | contraindication | 233916004 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
| Pregnancy, function | contraindication | 289908002 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Bone marrow depression | contraindication | 307762000 | |
| Primary malignant neoplasm | contraindication | 372087000 | |
| Malignant neoplasm of skin | contraindication | 372130007 | DOID:4159 |
| Peripheral vascular disease | contraindication | 400047006 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Blister | contraindication | 417237009 | |
| Denuded skin | contraindication | 418242004 | |
| Inflammatory dermatosis | contraindication | 703938007 | |
| Opportunistic Fungal Infection | contraindication | ||
| BK Polyomavirus Reactivation Nephropathy | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.68 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Enzyme | Ki | 5.26 | CHEMBL | |||||
| Carbonic anhydrase 1 | Enzyme | Ki | 5 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 5.02 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 5.06 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 5.04 | CHEMBL | |||||
| Carbonic anhydrase 3 | Enzyme | Ki | 5.57 | CHEMBL | |||||
| Carbonic anhydrase 14 | Enzyme | Ki | 4.94 | CHEMBL | |||||
| Endolysin | Enzyme | Kd | 4.04 | CHEMBL | |||||
| Carbonic anhydrase 15 | Enzyme | Ki | 4.98 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 4.76 | CHEMBL | |||||
| Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase | Enzyme | Ki | 4.10 | CHEMBL | |||||
| Carbonic anhydrase 2 | Enzyme | Ki | 4.59 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 4.86 | CHEMBL | |||||
| Beta-carbonic anhydrase 1 | Enzyme | Ki | 4.19 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017412 | VUID |
| N0000145800 | NUI |
| D00033 | KEGG_DRUG |
| 4017412 | VANDF |
| C0070570 | UMLSCUI |
| CHEBI:15882 | CHEBI |
| IPH | PDB_CHEM_ID |
| CHEMBL14060 | ChEMBL_ID |
| D019800 | MESH_DESCRIPTOR_UI |
| DB03255 | DRUGBANK_ID |
| 339NCG44TV | UNII |
| 996 | PUBCHEM_CID |
| 33290 | RXNORM |
| 11515 | MMSL |
| 5274 | MMSL |
| d05367 | MMSL |
| 003172 | NDDF |
| 003199 | NDDF |
| 116613007 | SNOMEDCT_US |
| 354036003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Sore throatcherry | HUMAN OTC DRUG LABEL | 1 | 0363-0376 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Medicated Lip Balm | HUMAN OTC DRUG LABEL | 3 | 0363-6040 | SALVE | 0.40 mg | TOPICAL | OTC monograph not final | 9 sections |
| Medicated Lip Balm | HUMAN OTC DRUG LABEL | 3 | 0363-6080 | STICK | 0.40 mg | TOPICAL | OTC monograph not final | 9 sections |
| Walgreens Sore Throat Cherry Flavor | HUMAN OTC DRUG LABEL | 1 | 0363-7030 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Sore Throat | HUMAN OTC DRUG LABEL | 2 | 0363-8910 | SPRAY | 1.50 mg | ORAL | OTC Monograph Drug | 13 sections |
| Walgreens Camphor Phenol Gel | HUMAN OTC DRUG LABEL | 2 | 0363-9425 | GEL | 4.70 mg | TOPICAL | OTC monograph not final | 8 sections |
| Calamine Phenolated Topical Suspension | HUMAN OTC DRUG LABEL | 2 | 0395-0407 | LOTION | 10 mg | TOPICAL | OTC Monograph Drug | 11 sections |
| Calamine Phenolated Topical Suspension | HUMAN OTC DRUG LABEL | 2 | 0395-9109 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |
| RugbyCherry Flavor | HUMAN OTC DRUG LABEL | 1 | 0536-1228 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| RugbyCherry Flavor | HUMAN OTC DRUG LABEL | 1 | 0536-1228 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| CHAPSTICK MEDICATED | HUMAN OTC DRUG LABEL | 4 | 0573-0720 | STICK | 5 mg | TOPICAL | OTC Monograph Drug | 13 sections |
| Sore Throat Cherry | HUMAN OTC DRUG LABEL | 1 | 0904-6305 | LIQUID | 1.50 g | ORAL | OTC Monograph Drug | 13 sections |
| Ambix First Aid | HUMAN OTC DRUG LABEL | 2 | 10038-250 | CREAM | 0.01 g | TOPICAL | OTC monograph not final | 11 sections |
| Lip Medex Lip Balm | HUMAN OTC DRUG LABEL | 4 | 10157-1194 | STICK | 0.60 g | TOPICAL | OTC monograph drug | 12 sections |
| Blistex Lip Medex | HUMAN OTC DRUG LABEL | 4 | 10157-8407 | PASTE | 0.60 g | TOPICAL | OTC monograph drug | 12 sections |
| Blistex Maximum Hydration Lip | HUMAN OTC DRUG LABEL | 4 | 10157-9913 | OINTMENT | 0.50 g | TOPICAL | OTC MONOGRAPH DRUG | 12 sections |
| Blistex con Medicacion Crema Labial | HUMAN OTC DRUG LABEL | 2 | 10157-9926 | STICK | 0.45 g | TOPICAL | EXPORT ONLY | 1 sections |
| Blistex Medicated | HUMAN OTC DRUG LABEL | 4 | 10157-9951 | OINTMENT | 0.50 g | TOPICAL | OTC monograph drug | 12 sections |
| Sore Throat | HUMAN OTC DRUG LABEL | 1 | 11822-3109 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 12 sections |
| Yat Tip Xiao | HUMAN OTC DRUG LABEL | 2 | 17429-010 | PLASTER | 40 mg | TOPICAL | OTC monograph final | 11 sections |
| SIGNATURE CARESORE THROAT CHERRY FLAVOR | HUMAN OTC DRUG LABEL | 1 | 21130-196 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Sore Throat | HUMAN OTC DRUG LABEL | 1 | 21130-376 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Budpak First Aid | HUMAN OTC DRUG LABEL | 2 | 27293-016 | CREAM | 0.01 g | TOPICAL | OTC monograph not final | 11 sections |
| TopCareCherry Flavor | HUMAN OTC DRUG LABEL | 1 | 36800-600 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| TopCareCherry Flavor | HUMAN OTC DRUG LABEL | 1 | 36800-600 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Topcare Sore ThroatMenthol Flavor | HUMAN OTC DRUG LABEL | 1 | 36800-606 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Topcare Sore ThroatMenthol Flavor | HUMAN OTC DRUG LABEL | 1 | 36800-606 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |
| Shopko Camphor Phenol Gel | HUMAN OTC DRUG LABEL | 2 | 37012-734 | GEL | 4.70 mg | TOPICAL | OTC monograph final | 8 sections |
| HEB Camphor Phenol | HUMAN OTC DRUG LABEL | 2 | 37808-105 | LIQUID | 47 mg | TOPICAL | OTC Monograph Drug | 11 sections |
| HEB Sore Throat Cherry Flavor | HUMAN OTC DRUG LABEL | 1 | 37808-803 | SPRAY | 1.40 g | ORAL | OTC Monograph Drug | 13 sections |