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glucose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 845 | 492-61-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 100 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 909 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,STK33,TEK | 29 | |||
| kinase-selectivity-class | ACVRL1,AXL,BMX,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK9,CHUK,DYRK1A,INSR,IRAK3,IRAK4,MAP2K6,MAP3K14,PDK1,PIK3CD,TGFBR1,ZAP70 | 22 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 17, 1946 | FDA | B BRAUN |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myelosuppression | 1038.45 | 9.99 | 827 | 164452 | 52764 | 90410404 |
| Hand deformity | 508.34 | 9.99 | 6 | 165273 | 296356 | 90166812 |
| Systemic lupus erythematosus | 482.11 | 9.99 | 50 | 165229 | 361846 | 90101322 |
| Glossodynia | 468.56 | 9.99 | 30 | 165249 | 321749 | 90141419 |
| Hypokalaemia | 467.02 | 9.99 | 849 | 164430 | 130267 | 90332901 |
| Duodenal ulcer perforation | 381.59 | 9.99 | 4 | 165275 | 221284 | 90241884 |
| Hyperkalaemia | 374.05 | 9.99 | 524 | 164755 | 64440 | 90398728 |
| Wound | 371.40 | 9.99 | 55 | 165224 | 302925 | 90160243 |
| Helicobacter infection | 370.75 | 9.99 | 9 | 165270 | 226841 | 90236327 |
| Pericarditis | 360.51 | 9.99 | 37 | 165242 | 270114 | 90193054 |
| Joint swelling | 346.69 | 9.99 | 248 | 165031 | 503052 | 89960116 |
| Arthropathy | 344.55 | 9.99 | 119 | 165160 | 366123 | 90097045 |
| Cardiac failure congestive | 316.32 | 9.99 | 611 | 164668 | 98083 | 90365085 |
| Folliculitis | 309.88 | 9.99 | 15 | 165264 | 204338 | 90258830 |
| Contraindicated product administered | 304.59 | 9.99 | 102 | 165177 | 320037 | 90143131 |
| Alopecia | 297.40 | 9.99 | 279 | 165000 | 494792 | 89968376 |
| Acute kidney injury | 294.72 | 9.99 | 1261 | 164018 | 319126 | 90144042 |
| Anaemia | 293.16 | 9.99 | 1347 | 163932 | 351455 | 90111713 |
| Muscle injury | 292.57 | 9.99 | 6 | 165273 | 176648 | 90286520 |
| Irritable bowel syndrome | 265.19 | 9.99 | 33 | 165246 | 207415 | 90255753 |
| Drug intolerance | 263.21 | 9.99 | 257 | 165022 | 447334 | 90015834 |
| Rheumatoid arthritis | 257.04 | 9.99 | 173 | 165106 | 362441 | 90100727 |
| Therapeutic product effect decreased | 252.78 | 9.99 | 95 | 165184 | 277476 | 90185692 |
| Impaired healing | 249.76 | 9.99 | 60 | 165219 | 234139 | 90229029 |
| White blood cell count decreased | 243.55 | 9.99 | 764 | 164515 | 166345 | 90296823 |
| Lower respiratory tract infection | 238.12 | 9.99 | 80 | 165199 | 250579 | 90212589 |
| Hypervolaemia | 237.62 | 9.99 | 296 | 164983 | 32461 | 90430707 |
| Abdominal discomfort | 234.21 | 9.99 | 317 | 164962 | 477011 | 89986157 |
| Psoriatic arthropathy | 232.93 | 9.99 | 64 | 165215 | 228271 | 90234897 |
| Atrial fibrillation | 231.93 | 9.99 | 650 | 164629 | 132961 | 90330207 |
| Synovitis | 231.44 | 9.99 | 159 | 165120 | 329593 | 90133575 |
| Musculoskeletal stiffness | 230.30 | 9.99 | 127 | 165152 | 296405 | 90166763 |
| Hepatic enzyme increased | 222.77 | 9.99 | 198 | 165081 | 360538 | 90102630 |
| Dehydration | 222.66 | 9.99 | 820 | 164459 | 193627 | 90269541 |
| Discomfort | 221.13 | 9.99 | 112 | 165167 | 274223 | 90188945 |
| Swelling | 215.10 | 9.99 | 269 | 165010 | 418789 | 90044379 |
| Sleep disorder due to general medical condition, insomnia type | 214.57 | 9.99 | 4 | 165275 | 128690 | 90334478 |
| Drug ineffective | 210.65 | 9.99 | 1572 | 163707 | 1382726 | 89080442 |
| Blood potassium decreased | 203.73 | 9.99 | 335 | 164944 | 47392 | 90415776 |
| Hypotension | 201.24 | 9.99 | 1144 | 164135 | 324253 | 90138915 |
| Ill-defined disorder | 199.81 | 9.99 | 46 | 165233 | 184845 | 90278323 |
| Sepsis | 196.45 | 9.99 | 747 | 164532 | 179067 | 90284101 |
| Neutrophil count decreased | 191.35 | 9.99 | 411 | 164868 | 71121 | 90392047 |
| Hypersensitivity | 189.51 | 9.99 | 337 | 164942 | 454340 | 90008828 |
| Fibromyalgia | 183.76 | 9.99 | 73 | 165206 | 206196 | 90256972 |
| Colitis microscopic | 178.08 | 9.99 | 154 | 165125 | 11005 | 90452163 |
| Blood cholesterol increased | 175.11 | 9.99 | 80 | 165199 | 207932 | 90255236 |
| Joint range of motion decreased | 172.29 | 9.99 | 22 | 165257 | 135621 | 90327547 |
| Pulmonary hypertension | 167.55 | 9.99 | 288 | 164991 | 42235 | 90420933 |
| Type 2 diabetes mellitus | 165.21 | 9.99 | 82 | 165197 | 203162 | 90260006 |
| Respiratory failure | 162.99 | 9.99 | 531 | 164748 | 117887 | 90345281 |
| Macular degeneration | 162.70 | 9.99 | 267 | 165012 | 37703 | 90425465 |
| Treatment failure | 159.12 | 9.99 | 192 | 165087 | 303736 | 90159432 |
| Facet joint syndrome | 156.62 | 9.99 | 5 | 165274 | 98384 | 90364784 |
| Hypoxia | 154.98 | 9.99 | 381 | 164898 | 72018 | 90391150 |
| Pneumonia | 153.64 | 9.99 | 1808 | 163471 | 636251 | 89826917 |
| Normal labour | 152.31 | 9.99 | 53 | 165226 | 564 | 90462604 |
| Acute respiratory failure | 151.48 | 9.99 | 277 | 165002 | 42641 | 90420527 |
| Grip strength decreased | 149.94 | 9.99 | 4 | 165275 | 92572 | 90370596 |
| Arthralgia | 149.64 | 9.99 | 822 | 164457 | 777700 | 89685468 |
| Infusion related reaction | 147.09 | 9.99 | 340 | 164939 | 416440 | 90046728 |
| Lip dry | 145.07 | 9.99 | 10 | 165269 | 100945 | 90362223 |
| Drug hypersensitivity | 142.98 | 9.99 | 405 | 164874 | 463204 | 89999964 |
| Bone marrow failure | 142.71 | 9.99 | 230 | 165049 | 31991 | 90431177 |
| Bursitis | 141.74 | 9.99 | 33 | 165246 | 131621 | 90331547 |
| Pneumonia aspiration | 141.68 | 9.99 | 262 | 165017 | 40678 | 90422490 |
| Product use issue | 141.49 | 9.99 | 240 | 165039 | 329679 | 90133489 |
| Vaginal flatulence | 141.11 | 9.99 | 143 | 165136 | 12495 | 90450673 |
| Injury | 137.25 | 9.99 | 96 | 165183 | 197253 | 90265915 |
| Intentional product use issue | 135.05 | 9.99 | 118 | 165161 | 216774 | 90246394 |
| C-reactive protein abnormal | 133.16 | 9.99 | 34 | 165245 | 127395 | 90335773 |
| Hyponatraemia | 133.01 | 9.99 | 539 | 164740 | 132999 | 90330169 |
| Blister | 132.49 | 9.99 | 162 | 165117 | 254836 | 90208332 |
| Proctitis | 130.56 | 9.99 | 150 | 165129 | 15109 | 90448059 |
| Colitis | 129.98 | 9.99 | 349 | 164930 | 69593 | 90393575 |
| Platelet count decreased | 129.46 | 9.99 | 544 | 164735 | 136425 | 90326743 |
| Sleep disorder | 129.13 | 9.99 | 103 | 165176 | 197927 | 90265241 |
| Gastrointestinal haemorrhage | 128.07 | 9.99 | 409 | 164870 | 89839 | 90373329 |
| Pleural effusion | 127.85 | 9.99 | 472 | 164807 | 111519 | 90351649 |
| Rash | 123.36 | 9.99 | 898 | 164381 | 795202 | 89667966 |
| Hypoglycaemia | 123.29 | 9.99 | 342 | 164937 | 69506 | 90393662 |
| Febrile neutropenia | 122.02 | 9.99 | 592 | 164687 | 157757 | 90305411 |
| Cytokine release syndrome | 121.60 | 9.99 | 198 | 165081 | 27775 | 90435393 |
| Inflammation | 121.41 | 9.99 | 89 | 165190 | 178503 | 90284665 |
| Constipation | 120.04 | 9.99 | 899 | 164380 | 279496 | 90183672 |
| Radiculopathy | 119.70 | 9.99 | 158 | 165121 | 18347 | 90444821 |
| Female genital tract fistula | 119.36 | 9.99 | 155 | 165124 | 17713 | 90445455 |
| Death | 118.85 | 9.99 | 1314 | 163965 | 455237 | 90007931 |
| Nasopharyngitis | 118.70 | 9.99 | 365 | 164914 | 406739 | 90056429 |
| Liver injury | 118.57 | 9.99 | 83 | 165196 | 170484 | 90292684 |
| Diarrhoea | 118.45 | 9.99 | 2384 | 162895 | 936806 | 89526362 |
| Paraesthesia oral | 117.67 | 9.99 | 209 | 165070 | 31450 | 90431718 |
| Glaucoma | 115.83 | 9.99 | 165 | 165114 | 20590 | 90442578 |
| Chronic sinusitis | 115.24 | 9.99 | 177 | 165102 | 23625 | 90439543 |
| Stomatitis | 114.86 | 9.99 | 203 | 165076 | 274495 | 90188673 |
| Cardiac arrest | 113.75 | 9.99 | 435 | 164844 | 104500 | 90358668 |
| Right ventricular failure | 113.60 | 9.99 | 157 | 165122 | 19048 | 90444120 |
| Renal failure | 111.35 | 9.99 | 504 | 164775 | 130503 | 90332665 |
| Night sweats | 110.73 | 9.99 | 48 | 165231 | 128718 | 90334450 |
| Mobility decreased | 106.91 | 9.99 | 183 | 165096 | 250551 | 90212617 |
| Oedema peripheral | 106.49 | 9.99 | 820 | 164459 | 257095 | 90206073 |
| Pain | 106.19 | 9.99 | 1235 | 164044 | 995106 | 89468062 |
| Hypercholesterolaemia | 105.26 | 9.99 | 27 | 165252 | 100865 | 90362303 |
| Plasma cell myeloma | 105.07 | 9.99 | 231 | 165048 | 40597 | 90422571 |
| Dyspnoea | 103.39 | 9.99 | 2213 | 163066 | 878742 | 89584426 |
| Urticaria | 100.97 | 9.99 | 267 | 165012 | 312467 | 90150701 |
| Pulmonary arterial hypertension | 100.07 | 9.99 | 175 | 165104 | 26012 | 90437156 |
| Diverticulitis | 97.97 | 9.99 | 239 | 165040 | 44948 | 90418220 |
| Delivery | 97.91 | 9.99 | 53 | 165226 | 1740 | 90461428 |
| Osteoarthritis | 97.84 | 9.99 | 128 | 165151 | 195602 | 90267566 |
| Cardiac failure | 95.86 | 9.99 | 425 | 164854 | 109071 | 90354097 |
| Vaginal discharge | 94.59 | 9.99 | 145 | 165134 | 19319 | 90443849 |
| Prescribed overdose | 91.18 | 9.99 | 32 | 165247 | 97593 | 90365575 |
| Wound infection | 90.95 | 9.99 | 40 | 165239 | 106362 | 90356806 |
| Blood urea increased | 89.78 | 9.99 | 182 | 165097 | 30231 | 90432937 |
| Pulmonary fibrosis | 89.42 | 9.99 | 42 | 165237 | 107461 | 90355707 |
| Pulmonary oedema | 88.66 | 9.99 | 282 | 164997 | 61798 | 90401370 |
| Oral candidiasis | 88.30 | 9.99 | 198 | 165081 | 35257 | 90427911 |
| Peripheral venous disease | 86.51 | 9.99 | 23 | 165256 | 83898 | 90379270 |
| Chronic obstructive pulmonary disease | 85.78 | 9.99 | 313 | 164966 | 73516 | 90389652 |
| Coma | 83.61 | 9.99 | 307 | 164972 | 72325 | 90390843 |
| Autoimmune disorder | 83.06 | 9.99 | 19 | 165260 | 76725 | 90386443 |
| Blepharospasm | 81.11 | 9.99 | 5 | 165274 | 55440 | 90407728 |
| Gastrointestinal disorder | 80.68 | 9.99 | 222 | 165057 | 256465 | 90206703 |
| Haemoglobin decreased | 80.16 | 9.99 | 538 | 164741 | 161418 | 90301750 |
| International normalised ratio increased | 78.91 | 9.99 | 227 | 165052 | 47089 | 90416079 |
| Wheezing | 78.55 | 9.99 | 201 | 165078 | 237879 | 90225289 |
| Hip arthroplasty | 78.34 | 9.99 | 21 | 165258 | 76187 | 90386981 |
| Pancytopenia | 77.61 | 9.99 | 428 | 164851 | 119835 | 90343333 |
| Bronchitis | 75.68 | 9.99 | 508 | 164771 | 152419 | 90310749 |
| Procedural pain | 75.05 | 9.99 | 179 | 165100 | 33181 | 90429987 |
| Infection | 74.55 | 9.99 | 373 | 164906 | 361721 | 90101447 |
| Dementia | 73.07 | 9.99 | 145 | 165134 | 23716 | 90439452 |
| Thrombocytopenia | 72.35 | 9.99 | 638 | 164641 | 208087 | 90255081 |
| Gait inability | 70.92 | 9.99 | 98 | 165181 | 146358 | 90316810 |
| Mental status changes | 70.35 | 9.99 | 210 | 165069 | 44469 | 90418699 |
| Lower limb fracture | 69.49 | 9.99 | 34 | 165245 | 84979 | 90378189 |
| Deep vein thrombosis | 69.44 | 9.99 | 341 | 164938 | 91279 | 90371889 |
| Psoriasis | 69.43 | 9.99 | 101 | 165178 | 147653 | 90315515 |
| Toxic epidermal necrolysis | 69.40 | 9.99 | 171 | 165108 | 32357 | 90430811 |
| Hypomagnesaemia | 68.56 | 9.99 | 180 | 165099 | 35408 | 90427760 |
| Urinary tract infection | 67.61 | 9.99 | 853 | 164426 | 304779 | 90158389 |
| Blood alkaline phosphatase increased | 67.37 | 9.99 | 217 | 165062 | 47862 | 90415306 |
| Obesity | 67.35 | 9.99 | 56 | 165223 | 105451 | 90357717 |
| Blood bilirubin increased | 67.20 | 9.99 | 203 | 165076 | 43267 | 90419901 |
| Coeliac disease | 65.32 | 9.99 | 4 | 165275 | 44606 | 90418562 |
| Encephalopathy | 64.52 | 9.99 | 209 | 165070 | 46235 | 90416933 |
| Drug abuse | 62.80 | 9.99 | 36 | 165243 | 82311 | 90380857 |
| Onychomadesis | 62.08 | 9.99 | 6 | 165273 | 45992 | 90417176 |
| Hyperglycaemia | 61.68 | 9.99 | 219 | 165060 | 50751 | 90412417 |
| Nail disorder | 61.24 | 9.99 | 16 | 165263 | 59051 | 90404117 |
| Knee arthroplasty | 61.13 | 9.99 | 38 | 165241 | 83144 | 90380024 |
| Sinusitis | 60.98 | 9.99 | 371 | 164908 | 342717 | 90120451 |
| Maternal exposure during pregnancy | 60.58 | 9.99 | 396 | 164883 | 359667 | 90103501 |
| Injection site reaction | 59.86 | 9.99 | 48 | 165231 | 92032 | 90371136 |
| Live birth | 59.73 | 9.99 | 35 | 165244 | 79072 | 90384096 |
| Blood creatinine increased | 59.61 | 9.99 | 352 | 164927 | 101034 | 90362134 |
| Condition aggravated | 59.11 | 9.99 | 749 | 164530 | 594796 | 89868372 |
| Dry mouth | 58.71 | 9.99 | 158 | 165121 | 183901 | 90279267 |
| Electrolyte imbalance | 58.45 | 9.99 | 132 | 165147 | 23613 | 90439555 |
| Epilepsy | 58.44 | 9.99 | 39 | 165240 | 82167 | 90381001 |
| Foot deformity | 58.43 | 9.99 | 18 | 165261 | 59633 | 90403535 |
| Haematochezia | 58.13 | 9.99 | 270 | 165009 | 70643 | 90392525 |
| Fall | 58.11 | 9.99 | 1216 | 164063 | 480594 | 89982574 |
| Septic shock | 58.00 | 9.99 | 305 | 164974 | 83855 | 90379313 |
| Cardiomegaly | 57.95 | 9.99 | 115 | 165164 | 18810 | 90444358 |
| Nausea | 57.54 | 9.99 | 2523 | 162756 | 1107793 | 89355375 |
| Asthenia | 57.37 | 9.99 | 1325 | 163954 | 532426 | 89930742 |
| Road traffic accident | 57.31 | 9.99 | 67 | 165212 | 107559 | 90355609 |
| Joint stiffness | 56.87 | 9.99 | 36 | 165243 | 78006 | 90385162 |
| Diabetes insipidus | 56.74 | 9.99 | 47 | 165232 | 3165 | 90460003 |
| Weight increased | 56.38 | 9.99 | 489 | 164790 | 417438 | 90045730 |
| Lactic acidosis | 54.50 | 9.99 | 209 | 165070 | 50254 | 90412914 |
| Premature delivery | 54.36 | 9.99 | 175 | 165104 | 38587 | 90424581 |
| Blood pressure decreased | 54.09 | 9.99 | 275 | 165004 | 74620 | 90388548 |
| Hypophagia | 53.84 | 9.99 | 166 | 165113 | 35771 | 90427397 |
| Adverse event | 53.48 | 9.99 | 82 | 165197 | 117336 | 90345832 |
| Migraine | 53.09 | 9.99 | 174 | 165105 | 190218 | 90272950 |
| Lupus-like syndrome | 53.04 | 9.99 | 12 | 165267 | 48834 | 90414334 |
| Syncope | 52.60 | 9.99 | 418 | 164861 | 132245 | 90330923 |
| Lung disorder | 52.19 | 9.99 | 123 | 165156 | 149760 | 90313408 |
| Bone erosion | 51.93 | 9.99 | 16 | 165263 | 53005 | 90410163 |
| Renal ischaemia | 51.83 | 9.99 | 25 | 165254 | 641 | 90462527 |
| Abdominal pain | 51.42 | 9.99 | 1010 | 164269 | 394711 | 90068457 |
| Blood magnesium decreased | 51.26 | 9.99 | 98 | 165181 | 15595 | 90447573 |
| Fluid retention | 51.24 | 9.99 | 305 | 164974 | 87786 | 90375382 |
| Blood cholesterol decreased | 51.21 | 9.99 | 36 | 165243 | 1895 | 90461273 |
| Rectal haemorrhage | 51.06 | 9.99 | 291 | 164988 | 82453 | 90380715 |
| Bradycardia | 50.51 | 9.99 | 293 | 164986 | 83554 | 90379614 |
| Blood glucose increased | 50.51 | 9.99 | 322 | 164957 | 94924 | 90368244 |
| General physical health deterioration | 50.36 | 9.99 | 410 | 164869 | 354705 | 90108463 |
| Onychomycosis | 50.11 | 9.99 | 5 | 165274 | 37371 | 90425797 |
| Exposure during pregnancy | 49.94 | 9.99 | 244 | 165035 | 238166 | 90225002 |
| Transfusion | 49.66 | 9.99 | 103 | 165176 | 17385 | 90445783 |
| Hypoaesthesia | 49.16 | 9.99 | 353 | 164926 | 313857 | 90149311 |
| Finger deformity | 48.02 | 9.99 | 3 | 165276 | 32894 | 90430274 |
| Peritonitis bacterial | 47.93 | 9.99 | 53 | 165226 | 5118 | 90458050 |
| Granulocyte count decreased | 47.79 | 9.99 | 38 | 165241 | 2414 | 90460754 |
| Electrocardiogram abnormal | 47.64 | 9.99 | 75 | 165204 | 10223 | 90452945 |
| Arthritis | 47.28 | 9.99 | 152 | 165127 | 167163 | 90296005 |
| Off label use | 47.17 | 9.99 | 1593 | 163686 | 1100659 | 89362509 |
| Coagulopathy | 47.13 | 9.99 | 120 | 165159 | 23169 | 90439999 |
| Weight decreased | 46.80 | 9.99 | 962 | 164317 | 378948 | 90084220 |
| Heparin-induced thrombocytopenia | 46.76 | 9.99 | 53 | 165226 | 5259 | 90457909 |
| Aspartate aminotransferase increased | 46.23 | 9.99 | 334 | 164945 | 102603 | 90360565 |
| Ascites | 46.15 | 9.99 | 191 | 165088 | 47549 | 90415619 |
| Pregnancy | 46.07 | 9.99 | 28 | 165251 | 62019 | 90401149 |
| Musculoskeletal pain | 46.04 | 9.99 | 159 | 165120 | 171092 | 90292076 |
| Dyspnoea exertional | 45.77 | 9.99 | 256 | 165023 | 72032 | 90391136 |
| Hypocalcaemia | 45.36 | 9.99 | 175 | 165104 | 42193 | 90420975 |
| Cardiogenic shock | 45.35 | 9.99 | 122 | 165157 | 24346 | 90438822 |
| Blood potassium increased | 45.24 | 9.99 | 110 | 165169 | 20639 | 90442529 |
| Oxygen saturation abnormal | 45.12 | 9.99 | 47 | 165232 | 4241 | 90458927 |
| Peripheral circulatory failure | 45.11 | 9.99 | 31 | 165248 | 1573 | 90461595 |
| Atrioventricular block first degree | 45.06 | 9.99 | 66 | 165213 | 8445 | 90454723 |
| Pulmonary embolism | 44.85 | 9.99 | 399 | 164880 | 130421 | 90332747 |
| Granulocytopenia | 44.78 | 9.99 | 57 | 165222 | 6384 | 90456784 |
| Sciatica | 44.09 | 9.99 | 73 | 165206 | 101309 | 90361859 |
| Prescribed underdose | 44.07 | 9.99 | 43 | 165236 | 74976 | 90388192 |
| Atrial flutter | 43.87 | 9.99 | 74 | 165205 | 10684 | 90452484 |
| Respiratory distress | 43.46 | 9.99 | 163 | 165116 | 38783 | 90424385 |
| Liver disorder | 42.63 | 9.99 | 99 | 165180 | 121170 | 90341998 |
| Neutropenia | 42.40 | 9.99 | 610 | 164669 | 224294 | 90238874 |
| Red blood cell sedimentation rate increased | 42.30 | 9.99 | 53 | 165226 | 82542 | 90380626 |
| PO2 increased | 42.22 | 9.99 | 24 | 165255 | 868 | 90462300 |
| Brain natriuretic peptide increased | 41.53 | 9.99 | 53 | 165226 | 5952 | 90457216 |
| Arrhythmia | 41.42 | 9.99 | 170 | 165109 | 42162 | 90421006 |
| Contusion | 41.36 | 9.99 | 278 | 165001 | 250938 | 90212230 |
| Metabolic alkalosis | 41.16 | 9.99 | 41 | 165238 | 3508 | 90459660 |
| Exostosis | 40.84 | 9.99 | 23 | 165256 | 53111 | 90410057 |
| Confusional state | 40.81 | 9.99 | 479 | 164800 | 385726 | 90077442 |
| Paraesthesia | 40.73 | 9.99 | 278 | 165001 | 250048 | 90213120 |
| Back injury | 40.67 | 9.99 | 17 | 165262 | 46605 | 90416563 |
| Multiple allergies | 40.45 | 9.99 | 87 | 165192 | 15059 | 90448109 |
| Disability | 40.44 | 9.99 | 12 | 165267 | 40733 | 90422435 |
| Hypernatraemia | 40.19 | 9.99 | 66 | 165213 | 9321 | 90453847 |
| Non-cardiogenic pulmonary oedema | 40.07 | 9.99 | 26 | 165253 | 1198 | 90461970 |
| Neuroglycopenia | 39.76 | 9.99 | 25 | 165254 | 1090 | 90462078 |
| PCO2 increased | 38.40 | 9.99 | 26 | 165253 | 1287 | 90461881 |
| Vascular device infection | 38.26 | 9.99 | 74 | 165205 | 11878 | 90451290 |
| Skin reaction | 37.96 | 9.99 | 96 | 165183 | 18457 | 90444711 |
| Clostridium difficile colitis | 37.83 | 9.99 | 121 | 165158 | 26585 | 90436583 |
| Metabolic acidosis | 37.83 | 9.99 | 201 | 165078 | 55475 | 90407693 |
| Taste disorder | 37.65 | 9.99 | 34 | 165245 | 61512 | 90401656 |
| Melaena | 37.48 | 9.99 | 144 | 165135 | 34653 | 90428515 |
| Hypovolaemia | 37.41 | 9.99 | 75 | 165204 | 12356 | 90450812 |
| Neuropathy peripheral | 37.26 | 9.99 | 398 | 164881 | 136572 | 90326596 |
| Vomiting | 37.16 | 9.99 | 1775 | 163504 | 786518 | 89676650 |
| Cardiac failure acute | 37.14 | 9.99 | 73 | 165206 | 11856 | 90451312 |
| Haematocrit decreased | 37.07 | 9.99 | 163 | 165116 | 41669 | 90421499 |
| Hepatic function abnormal | 37.02 | 9.99 | 175 | 165104 | 46113 | 90417055 |
| Asthma | 36.92 | 9.99 | 274 | 165005 | 241886 | 90221282 |
| Cellulitis | 36.86 | 9.99 | 289 | 164990 | 91048 | 90372120 |
| Gastric polyps | 36.76 | 9.99 | 44 | 165235 | 4628 | 90458540 |
| Transient ischaemic attack | 36.57 | 9.99 | 166 | 165113 | 43010 | 90420158 |
| Hypoalbuminaemia | 36.51 | 9.99 | 86 | 165193 | 15811 | 90447357 |
| Laryngitis | 36.18 | 9.99 | 24 | 165255 | 50729 | 90412439 |
| Suicidal ideation | 36.17 | 9.99 | 49 | 165230 | 73806 | 90389362 |
| Cor pulmonale | 36.09 | 9.99 | 30 | 165249 | 2030 | 90461138 |
| Adverse drug reaction | 35.84 | 9.99 | 102 | 165177 | 116599 | 90346569 |
| Tachycardia | 35.65 | 9.99 | 442 | 164837 | 157231 | 90305937 |
| Full blood count decreased | 35.43 | 9.99 | 127 | 165152 | 29562 | 90433606 |
| Pericardial effusion | 35.32 | 9.99 | 147 | 165132 | 36686 | 90426482 |
| Generalised oedema | 35.31 | 9.99 | 95 | 165184 | 18958 | 90444210 |
| Therapy non-responder | 34.70 | 9.99 | 130 | 165149 | 136574 | 90326594 |
| Prothrombin time prolonged | 34.38 | 9.99 | 63 | 165216 | 9709 | 90453459 |
| Stupor | 34.21 | 9.99 | 46 | 165233 | 5436 | 90457732 |
| Atelectasis | 34.04 | 9.99 | 110 | 165169 | 24299 | 90438869 |
| Hyperaldosteronism | 33.84 | 9.99 | 15 | 165264 | 315 | 90462853 |
| Electrocardiogram T wave peaked | 33.71 | 9.99 | 14 | 165265 | 249 | 90462919 |
| Activated partial thromboplastin time prolonged | 33.48 | 9.99 | 55 | 165224 | 7770 | 90455398 |
| Tachypnoea | 33.39 | 9.99 | 100 | 165179 | 21209 | 90441959 |
| Joint dislocation | 33.27 | 9.99 | 20 | 165259 | 44562 | 90418606 |
| Leukocytosis | 33.17 | 9.99 | 128 | 165151 | 30862 | 90432306 |
| Thrombosis | 33.07 | 9.99 | 238 | 165041 | 73013 | 90390155 |
| Oxygen saturation decreased | 32.90 | 9.99 | 320 | 164959 | 107163 | 90356005 |
| Malnutrition | 32.86 | 9.99 | 91 | 165188 | 18467 | 90444701 |
| Blood bicarbonate decreased | 32.48 | 9.99 | 34 | 165245 | 3085 | 90460083 |
| Bacteraemia | 32.47 | 9.99 | 102 | 165177 | 22198 | 90440970 |
| Blood albumin decreased | 32.37 | 9.99 | 85 | 165194 | 16718 | 90446450 |
| Intentional self-injury | 32.27 | 9.99 | 7 | 165272 | 29327 | 90433841 |
| Acute respiratory distress syndrome | 31.95 | 9.99 | 120 | 165159 | 28566 | 90434602 |
| Failure to thrive | 31.86 | 9.99 | 56 | 165223 | 8355 | 90454813 |
| Hypophosphataemia | 31.59 | 9.99 | 78 | 165201 | 14776 | 90448392 |
| Chronic kidney disease | 31.28 | 9.99 | 177 | 165102 | 50014 | 90413154 |
| Immune effector cell-associated neurotoxicity syndrome | 30.93 | 9.99 | 45 | 165234 | 5723 | 90457445 |
| Blood immunoglobulin M increased | 30.53 | 9.99 | 23 | 165256 | 1349 | 90461819 |
| Somnolence | 29.99 | 9.99 | 542 | 164737 | 208542 | 90254626 |
| Abdominal pain upper | 29.81 | 9.99 | 427 | 164852 | 332247 | 90130921 |
| Metabolic encephalopathy | 29.62 | 9.99 | 48 | 165231 | 6704 | 90456464 |
| Acute left ventricular failure | 29.44 | 9.99 | 22 | 165257 | 1274 | 90461894 |
| Oxygen consumption increased | 29.39 | 9.99 | 39 | 165240 | 4550 | 90458618 |
| Therapeutic response decreased | 29.38 | 9.99 | 76 | 165203 | 89653 | 90373515 |
| Product quality issue | 29.31 | 9.99 | 63 | 165216 | 79262 | 90383906 |
| Adverse reaction | 29.04 | 9.99 | 9 | 165270 | 29703 | 90433465 |
| Ventricular tachycardia | 28.90 | 9.99 | 105 | 165174 | 24603 | 90438565 |
| Calcium deficiency | 28.89 | 9.99 | 22 | 165257 | 1311 | 90461857 |
| Left ventricular failure | 28.54 | 9.99 | 47 | 165232 | 6653 | 90456515 |
| Product residue present | 28.31 | 9.99 | 37 | 165242 | 4254 | 90458914 |
| Chills | 28.14 | 9.99 | 366 | 164913 | 131615 | 90331553 |
| Small intestinal obstruction | 28.10 | 9.99 | 94 | 165185 | 21140 | 90442028 |
| Walking aid user | 27.82 | 9.99 | 15 | 165264 | 35491 | 90427677 |
| Neonatal gastrointestinal disorder | 27.20 | 9.99 | 9 | 165270 | 81 | 90463087 |
| Blood creatine increased | 27.19 | 9.99 | 47 | 165232 | 6920 | 90456248 |
| Emphysema | 27.10 | 9.99 | 65 | 165214 | 12090 | 90451078 |
| Injection site swelling | 27.04 | 9.99 | 42 | 165237 | 59797 | 90403371 |
| Parkinsonism | 26.94 | 9.99 | 71 | 165208 | 13994 | 90449174 |
| Fluid replacement | 26.94 | 9.99 | 16 | 165263 | 629 | 90462539 |
| Frequent bowel movements | 26.87 | 9.99 | 187 | 165092 | 56748 | 90406420 |
| Blood pH decreased | 26.85 | 9.99 | 28 | 165251 | 2530 | 90460638 |
| Arteriosclerosis coronary artery | 26.61 | 9.99 | 56 | 165223 | 9547 | 90453621 |
| Blood chloride decreased | 26.48 | 9.99 | 44 | 165235 | 6275 | 90456893 |
| Product use in unapproved indication | 26.26 | 9.99 | 443 | 164836 | 335793 | 90127375 |
| Chest discomfort | 25.94 | 9.99 | 375 | 164904 | 137990 | 90325178 |
| Epistaxis | 25.84 | 9.99 | 253 | 165026 | 84872 | 90378296 |
| Haemorrhage | 25.55 | 9.99 | 215 | 165064 | 69154 | 90394014 |
| Blood immunoglobulin A decreased | 25.55 | 9.99 | 23 | 165256 | 1733 | 90461435 |
| Upper gastrointestinal haemorrhage | 25.50 | 9.99 | 96 | 165183 | 22880 | 90440288 |
| Maternal exposure timing unspecified | 25.49 | 9.99 | 5 | 165274 | 22478 | 90440690 |
| Unresponsive to stimuli | 25.47 | 9.99 | 137 | 165142 | 37984 | 90425184 |
| Hepatitis | 25.46 | 9.99 | 57 | 165222 | 70682 | 90392486 |
| Oesophageal spasm | 25.38 | 9.99 | 31 | 165248 | 3330 | 90459838 |
| Haematoma | 25.19 | 9.99 | 139 | 165140 | 38909 | 90424259 |
| Pulse absent | 25.15 | 9.99 | 42 | 165237 | 6013 | 90457155 |
| Erythema | 25.14 | 9.99 | 571 | 164708 | 228675 | 90234493 |
| Pneumonia staphylococcal | 24.97 | 9.99 | 32 | 165247 | 3609 | 90459559 |
| Hyperlipidaemia | 24.81 | 9.99 | 95 | 165184 | 22821 | 90440347 |
| Liver function test increased | 24.73 | 9.99 | 76 | 165203 | 84779 | 90378389 |
| Shock | 24.64 | 9.99 | 111 | 165168 | 28667 | 90434501 |
| Drug tolerance decreased | 24.56 | 9.99 | 14 | 165265 | 32116 | 90431052 |
| Vitamin B1 increased | 24.49 | 9.99 | 10 | 165269 | 170 | 90462998 |
| Tonsillar haemorrhage | 23.86 | 9.99 | 11 | 165268 | 254 | 90462914 |
| Gout | 23.53 | 9.99 | 76 | 165203 | 16783 | 90446385 |
| Muscle spasticity | 23.47 | 9.99 | 18 | 165261 | 35304 | 90427864 |
| Cerebrovascular accident | 23.24 | 9.99 | 335 | 164944 | 123198 | 90339970 |
| Catheter site haemorrhage | 23.23 | 9.99 | 31 | 165248 | 3637 | 90459531 |
| Loss of personal independence in daily activities | 23.20 | 9.99 | 149 | 165130 | 135956 | 90327212 |
| Pseudomonal bacteraemia | 23.06 | 9.99 | 23 | 165256 | 1971 | 90461197 |
| Acute myocardial infarction | 23.05 | 9.99 | 125 | 165154 | 34765 | 90428403 |
| Micturition disorder | 23.04 | 9.99 | 28 | 165251 | 2992 | 90460176 |
| Urosepsis | 22.97 | 9.99 | 88 | 165191 | 21144 | 90442024 |
| Staphylococcal sepsis | 22.91 | 9.99 | 52 | 165227 | 9331 | 90453837 |
| Lethargy | 22.89 | 9.99 | 195 | 165084 | 62944 | 90400224 |
| Hospice care | 22.84 | 9.99 | 53 | 165226 | 9651 | 90453517 |
| Urine chloride decreased | 22.83 | 9.99 | 8 | 165271 | 87 | 90463081 |
| Blood loss anaemia | 22.36 | 9.99 | 54 | 165225 | 10086 | 90453082 |
| Cerebral haematoma | 22.33 | 9.99 | 33 | 165246 | 4256 | 90458912 |
| Hypercapnia | 22.18 | 9.99 | 42 | 165237 | 6635 | 90456533 |
| Injection site pain | 22.17 | 9.99 | 206 | 165073 | 173493 | 90289675 |
| Decreased appetite | 21.93 | 9.99 | 867 | 164412 | 375673 | 90087495 |
| Rheumatic disorder | 21.89 | 9.99 | 29 | 165250 | 3379 | 90459789 |
| Vitamin B1 decreased | 21.57 | 9.99 | 13 | 165266 | 525 | 90462643 |
| Pneumothorax spontaneous | 21.38 | 9.99 | 16 | 165263 | 929 | 90462239 |
| Congestive hepatopathy | 21.34 | 9.99 | 27 | 165252 | 3006 | 90460162 |
| Supraventricular tachycardia | 21.33 | 9.99 | 72 | 165207 | 16264 | 90446904 |
| Blood lactic acid decreased | 21.21 | 9.99 | 12 | 165267 | 430 | 90462738 |
| Food allergy | 21.11 | 9.99 | 10 | 165269 | 25468 | 90437700 |
| Polyarthritis | 20.97 | 9.99 | 4 | 165275 | 18346 | 90444822 |
| Torsade de pointes | 20.79 | 9.99 | 68 | 165211 | 15114 | 90448054 |
| Multiple drug therapy | 20.75 | 9.99 | 42 | 165237 | 6967 | 90456201 |
| Peripheral swelling | 20.74 | 9.99 | 584 | 164695 | 412522 | 90050646 |
| Gastrooesophageal reflux disease | 20.70 | 9.99 | 422 | 164857 | 165915 | 90297253 |
| Renal impairment | 20.67 | 9.99 | 288 | 164991 | 105133 | 90358035 |
| Nail dystrophy | 20.65 | 9.99 | 18 | 165261 | 1300 | 90461868 |
| Stevens-Johnson syndrome | 20.60 | 9.99 | 107 | 165172 | 29269 | 90433899 |
| Pain in jaw | 20.56 | 9.99 | 154 | 165125 | 47831 | 90415337 |
| Neonatal respiratory depression | 20.39 | 9.99 | 9 | 165270 | 187 | 90462981 |
| Product compounding quality issue | 20.39 | 9.99 | 6 | 165273 | 35 | 90463133 |
| Alanine aminotransferase increased | 20.34 | 9.99 | 316 | 164963 | 118022 | 90345146 |
| Thyroid disorder | 20.31 | 9.99 | 75 | 165204 | 17710 | 90445458 |
| Mental status changes postoperative | 20.30 | 9.99 | 9 | 165270 | 189 | 90462979 |
| Chronic respiratory failure | 20.24 | 9.99 | 25 | 165254 | 2716 | 90460452 |
| Ventricular fibrillation | 20.23 | 9.99 | 64 | 165215 | 13980 | 90449188 |
| Agranulocytosis | 20.23 | 9.99 | 121 | 165158 | 34881 | 90428287 |
| Myocardial infarction | 20.18 | 9.99 | 288 | 164991 | 105684 | 90357484 |
| Blood potassium abnormal | 20.04 | 9.99 | 26 | 165253 | 2968 | 90460200 |
| Initial insomnia | 19.92 | 9.99 | 49 | 165230 | 9261 | 90453907 |
| Hyperthyroidism | 19.90 | 9.99 | 76 | 165203 | 18234 | 90444934 |
| Injection site bruising | 19.78 | 9.99 | 41 | 165238 | 52266 | 90410902 |
| Subdural haematoma | 19.69 | 9.99 | 71 | 165208 | 16574 | 90446594 |
| Hiatus hernia | 19.64 | 9.99 | 95 | 165184 | 25266 | 90437902 |
| Lip erosion | 19.58 | 9.99 | 17 | 165262 | 1221 | 90461947 |
| Fatigue | 19.55 | 9.99 | 1826 | 163453 | 1152197 | 89310971 |
| Mitral valve incompetence | 19.37 | 9.99 | 87 | 165192 | 22437 | 90440731 |
| Injection site erythema | 19.37 | 9.99 | 103 | 165176 | 98399 | 90364769 |
| Ear infection | 19.28 | 9.99 | 64 | 165215 | 69711 | 90393457 |
| Insomnia | 19.23 | 9.99 | 462 | 164817 | 333012 | 90130156 |
| Lymphoedema | 19.20 | 9.99 | 62 | 165217 | 13691 | 90449477 |
| Cardiac dysfunction | 19.20 | 9.99 | 28 | 165251 | 3569 | 90459599 |
| Oesophageal pain | 19.06 | 9.99 | 31 | 165248 | 4343 | 90458825 |
| Diabetes mellitus inadequate control | 19.05 | 9.99 | 76 | 165203 | 18608 | 90444560 |
| Hypertension | 19.04 | 9.99 | 663 | 164616 | 456869 | 90006299 |
| Blood sodium decreased | 18.97 | 9.99 | 100 | 165179 | 27513 | 90435655 |
| Red blood cell count decreased | 18.88 | 9.99 | 147 | 165132 | 46204 | 90416964 |
| Haemoglobin increased | 18.87 | 9.99 | 42 | 165237 | 7439 | 90455729 |
| Staphylococcal infection | 18.84 | 9.99 | 152 | 165127 | 48287 | 90414881 |
| Polyuria | 18.54 | 9.99 | 50 | 165229 | 9990 | 90453178 |
| Renal tubular acidosis | 18.54 | 9.99 | 22 | 165257 | 2293 | 90460875 |
| Toxicity to various agents | 18.52 | 9.99 | 392 | 164887 | 287454 | 90175714 |
| Delirium | 18.43 | 9.99 | 113 | 165166 | 104246 | 90358922 |
| Cholelithiasis | 18.43 | 9.99 | 161 | 165118 | 52345 | 90410823 |
| Disseminated intravascular coagulation | 18.38 | 9.99 | 83 | 165196 | 21455 | 90441713 |
| Dysuria | 18.35 | 9.99 | 129 | 165150 | 39272 | 90423896 |
| Urine sodium decreased | 18.31 | 9.99 | 8 | 165271 | 162 | 90463006 |
| Device related sepsis | 18.27 | 9.99 | 32 | 165247 | 4761 | 90458407 |
| Wrong patient | 18.26 | 9.99 | 14 | 165265 | 843 | 90462325 |
| Catheter management | 18.23 | 9.99 | 25 | 165254 | 3011 | 90460157 |
| Skin candida | 18.17 | 9.99 | 19 | 165260 | 1722 | 90461446 |
| Posterior reversible encephalopathy syndrome | 18.15 | 9.99 | 9 | 165270 | 22330 | 90440838 |
| Cyanosis | 18.15 | 9.99 | 77 | 165202 | 19378 | 90443790 |
| Spontaneous haemorrhage | 17.91 | 9.99 | 13 | 165266 | 720 | 90462448 |
| Shock haemorrhagic | 17.82 | 9.99 | 56 | 165223 | 12189 | 90450979 |
| Clostridium difficile infection | 17.67 | 9.99 | 120 | 165159 | 36125 | 90427043 |
| Peptic ulcer | 17.65 | 9.99 | 34 | 165245 | 5441 | 90457727 |
| Wrong technique in product usage process | 17.55 | 9.99 | 69 | 165210 | 71502 | 90391666 |
| Multiple organ dysfunction syndrome | 17.39 | 9.99 | 196 | 165083 | 68140 | 90395028 |
| Hypotonia | 17.32 | 9.99 | 53 | 165226 | 11373 | 90451795 |
| Haemoptysis | 17.26 | 9.99 | 112 | 165167 | 33208 | 90429960 |
| Extravasation | 17.18 | 9.99 | 24 | 165255 | 2940 | 90460228 |
| Blood immunoglobulin G increased | 17.13 | 9.99 | 24 | 165255 | 2948 | 90460220 |
| Haemorrhoidal haemorrhage | 17.09 | 9.99 | 33 | 165246 | 5290 | 90457878 |
| Pyrexia | 17.05 | 9.99 | 1412 | 163867 | 659073 | 89804095 |
| Tenosynovitis | 17.02 | 9.99 | 3 | 165276 | 14564 | 90448604 |
| Bradykinesia | 17.00 | 9.99 | 38 | 165241 | 6750 | 90456418 |
| Acute pulmonary oedema | 16.99 | 9.99 | 47 | 165232 | 9533 | 90453635 |
| Rash vesicular | 16.93 | 9.99 | 6 | 165273 | 18191 | 90444977 |
| Hyperdynamic left ventricle | 16.92 | 9.99 | 9 | 165270 | 285 | 90462883 |
| Ileus | 16.62 | 9.99 | 67 | 165212 | 16479 | 90446689 |
| Foetal growth restriction | 16.61 | 9.99 | 46 | 165233 | 9334 | 90453834 |
| Haemodialysis | 16.60 | 9.99 | 44 | 165235 | 8703 | 90454465 |
| Intensive care | 16.57 | 9.99 | 16 | 165263 | 1318 | 90461850 |
| Ataxia | 16.51 | 9.99 | 71 | 165208 | 17971 | 90445197 |
| Hydronephrosis | 16.49 | 9.99 | 55 | 165224 | 12347 | 90450821 |
| Hypochloraemia | 16.36 | 9.99 | 22 | 165257 | 2600 | 90460568 |
| Oxygen therapy | 16.34 | 9.99 | 24 | 165255 | 3078 | 90460090 |
| Therapy partial responder | 16.29 | 9.99 | 10 | 165269 | 22033 | 90441135 |
| Lung infiltration | 16.26 | 9.99 | 63 | 165216 | 15219 | 90447949 |
| Blood pressure diastolic abnormal | 16.17 | 9.99 | 8 | 165271 | 19873 | 90443295 |
| Unevaluable event | 16.15 | 9.99 | 162 | 165117 | 54686 | 90408482 |
| Incision site pain | 16.13 | 9.99 | 16 | 165263 | 1362 | 90461806 |
| Device related infection | 16.11 | 9.99 | 91 | 165188 | 25695 | 90437473 |
| Abortion spontaneous | 16.05 | 9.99 | 48 | 165231 | 54008 | 90409160 |
| Left ventricular dysfunction | 16.04 | 9.99 | 61 | 165218 | 14608 | 90448560 |
| Nodule | 16.02 | 9.99 | 15 | 165264 | 26671 | 90436497 |
| Cataract operation | 16.00 | 9.99 | 35 | 165244 | 6128 | 90457040 |
| Cardiac aneurysm | 15.98 | 9.99 | 14 | 165265 | 1018 | 90462150 |
| Neck pain | 15.93 | 9.99 | 132 | 165147 | 113831 | 90349337 |
| Acinetobacter sepsis | 15.93 | 9.99 | 3 | 165276 | 0 | 90463168 |
| Alkalosis | 15.75 | 9.99 | 11 | 165268 | 573 | 90462595 |
| Orthopnoea | 15.72 | 9.99 | 37 | 165242 | 6798 | 90456370 |
| Osmotic demyelination syndrome | 15.72 | 9.99 | 14 | 165265 | 1040 | 90462128 |
| Bezoar | 15.64 | 9.99 | 22 | 165257 | 2712 | 90460456 |
| Coronary artery disease | 15.61 | 9.99 | 110 | 165169 | 33513 | 90429655 |
| Burkholderia test positive | 15.56 | 9.99 | 8 | 165271 | 236 | 90462932 |
| Schizophrenia | 15.53 | 9.99 | 4 | 165275 | 14910 | 90448258 |
| Blood glucose decreased | 15.52 | 9.99 | 84 | 165195 | 23345 | 90439823 |
| Haematemesis | 15.46 | 9.99 | 110 | 165169 | 33616 | 90429552 |
| Confusion postoperative | 15.35 | 9.99 | 8 | 165271 | 243 | 90462925 |
| Dermatitis contact | 15.25 | 9.99 | 57 | 165222 | 13538 | 90449630 |
| Haemorrhoids | 15.23 | 9.99 | 92 | 165187 | 26610 | 90436558 |
| Myositis | 15.15 | 9.99 | 13 | 165266 | 24115 | 90439053 |
| Vascular encephalopathy | 15.15 | 9.99 | 12 | 165267 | 758 | 90462410 |
| Cardio-respiratory arrest | 15.13 | 9.99 | 179 | 165100 | 62961 | 90400207 |
| Catheterisation cardiac | 15.03 | 9.99 | 30 | 165249 | 4926 | 90458242 |
| Nodal arrhythmia | 15.01 | 9.99 | 15 | 165264 | 1288 | 90461880 |
| Colitis ulcerative | 14.95 | 9.99 | 172 | 165107 | 60094 | 90403074 |
| Skin dystrophy | 14.92 | 9.99 | 5 | 165274 | 47 | 90463121 |
| Drug tolerance | 14.89 | 9.99 | 7 | 165272 | 17909 | 90445259 |
| Nutritional condition abnormal | 14.89 | 9.99 | 13 | 165266 | 941 | 90462227 |
| Drug interaction | 14.81 | 9.99 | 631 | 164648 | 275822 | 90187346 |
| Palpitations | 14.81 | 9.99 | 340 | 164939 | 136388 | 90326780 |
| Presyncope | 14.74 | 9.99 | 104 | 165175 | 31701 | 90431467 |
| Immune-mediated enterocolitis | 14.67 | 9.99 | 29 | 165250 | 4728 | 90458440 |
| Gastritis | 14.64 | 9.99 | 128 | 165151 | 41625 | 90421543 |
| Hernia | 14.60 | 9.99 | 58 | 165221 | 14173 | 90448995 |
| Leukoplakia oral | 14.58 | 9.99 | 8 | 165271 | 270 | 90462898 |
| Candida infection | 14.42 | 9.99 | 109 | 165170 | 33948 | 90429220 |
| Paracentesis | 14.41 | 9.99 | 13 | 165266 | 982 | 90462186 |
| Pustular psoriasis | 14.31 | 9.99 | 8 | 165271 | 18548 | 90444620 |
| Hepatic cirrhosis | 14.26 | 9.99 | 63 | 165216 | 63190 | 90399978 |
| Pseudomonal sepsis | 14.22 | 9.99 | 27 | 165252 | 4275 | 90458893 |
| Cardiac output increased | 14.21 | 9.99 | 10 | 165269 | 527 | 90462641 |
| Thyroxine decreased | 14.18 | 9.99 | 11 | 165268 | 674 | 90462494 |
| Pulseless electrical activity | 14.07 | 9.99 | 42 | 165237 | 8890 | 90454278 |
| Oxalosis | 14.06 | 9.99 | 5 | 165274 | 57 | 90463111 |
| Head injury | 13.88 | 9.99 | 101 | 165178 | 31087 | 90432081 |
| Headache | 13.88 | 9.99 | 1370 | 163909 | 861376 | 89601792 |
| Dermatitis exfoliative | 13.88 | 9.99 | 31 | 165248 | 5505 | 90457663 |
| Acne | 13.87 | 9.99 | 19 | 165260 | 28488 | 90434680 |
| Back pain | 13.79 | 9.99 | 709 | 164570 | 316466 | 90146702 |
| Gastroenteritis | 13.79 | 9.99 | 96 | 165183 | 29133 | 90434035 |
| Cystitis | 13.79 | 9.99 | 184 | 165095 | 66534 | 90396634 |
| Pneumonitis | 13.75 | 9.99 | 132 | 165147 | 44038 | 90419130 |
| Productive cough | 13.71 | 9.99 | 207 | 165072 | 76856 | 90386312 |
| Leukopenia | 13.70 | 9.99 | 259 | 165020 | 100451 | 90362717 |
| Posthaemorrhagic hydrocephalus | 13.68 | 9.99 | 5 | 165274 | 62 | 90463106 |
| Hyperbilirubinaemia | 13.66 | 9.99 | 56 | 165223 | 13880 | 90449288 |
| Hyperchloraemia | 13.65 | 9.99 | 12 | 165267 | 876 | 90462292 |
| Hyperpyrexia | 13.47 | 9.99 | 28 | 165251 | 4733 | 90458435 |
| Oral papilloma | 13.47 | 9.99 | 5 | 165274 | 65 | 90463103 |
| Electrocardiogram QT prolonged | 13.43 | 9.99 | 196 | 165083 | 72260 | 90390908 |
| Therapeutic product effect incomplete | 13.38 | 9.99 | 261 | 165018 | 193635 | 90269533 |
| Haemorrhage intracranial | 13.37 | 9.99 | 59 | 165220 | 15103 | 90448065 |
| Right ventricular dilatation | 13.37 | 9.99 | 16 | 165263 | 1683 | 90461485 |
| Vascular pseudoaneurysm | 13.19 | 9.99 | 16 | 165263 | 1707 | 90461461 |
| Genital erosion | 13.14 | 9.99 | 9 | 165270 | 454 | 90462714 |
| Sinus tachycardia | 13.07 | 9.99 | 93 | 165186 | 28420 | 90434748 |
| Panniculitis | 13.06 | 9.99 | 5 | 165274 | 14453 | 90448715 |
| Adenocarcinoma | 13.05 | 9.99 | 22 | 165257 | 3174 | 90459994 |
| Polyglandular disorder | 13.01 | 9.99 | 7 | 165272 | 227 | 90462941 |
| Differentiation syndrome | 12.96 | 9.99 | 14 | 165265 | 1317 | 90461851 |
| Corynebacterium test positive | 12.94 | 9.99 | 5 | 165274 | 73 | 90463095 |
| Incorrect route of product administration | 12.93 | 9.99 | 48 | 165231 | 50578 | 90412590 |
| Endocrine disorder | 12.85 | 9.99 | 12 | 165267 | 948 | 90462220 |
| Myoglobin blood increased | 12.85 | 9.99 | 15 | 165264 | 1537 | 90461631 |
| Disease progression | 12.74 | 9.99 | 375 | 164904 | 156240 | 90306928 |
| Urinary tract obstruction | 12.72 | 9.99 | 18 | 165261 | 2231 | 90460937 |
| Blood pressure abnormal | 12.72 | 9.99 | 70 | 165209 | 19575 | 90443593 |
| Central nervous system injury | 12.69 | 9.99 | 6 | 165273 | 147 | 90463021 |
| Ear pain | 12.69 | 9.99 | 58 | 165221 | 57644 | 90405524 |
| Anticoagulation drug level above therapeutic | 12.67 | 9.99 | 17 | 165262 | 2005 | 90461163 |
| Manufacturing laboratory analytical testing issue | 12.64 | 9.99 | 3 | 165276 | 6 | 90463162 |
| Cholecystitis | 12.60 | 9.99 | 63 | 165216 | 16977 | 90446191 |
| Use of accessory respiratory muscles | 12.60 | 9.99 | 8 | 165271 | 355 | 90462813 |
| Product administration error | 12.59 | 9.99 | 87 | 165192 | 26336 | 90436832 |
| Blood pressure fluctuation | 12.55 | 9.99 | 51 | 165228 | 52362 | 90410806 |
| Serratia sepsis | 12.52 | 9.99 | 5 | 165274 | 80 | 90463088 |
| International normalised ratio decreased | 12.46 | 9.99 | 27 | 165252 | 4697 | 90458471 |
| Sinoatrial block | 12.38 | 9.99 | 12 | 165267 | 993 | 90462175 |
| Atrioventricular block second degree | 12.38 | 9.99 | 26 | 165253 | 4426 | 90458742 |
| Pulmonary arterial pressure increased | 12.23 | 9.99 | 24 | 165255 | 3892 | 90459276 |
| Mitral valve disease | 12.22 | 9.99 | 19 | 165260 | 2563 | 90460605 |
| Haematuria | 12.19 | 9.99 | 107 | 165172 | 34830 | 90428338 |
| Infusion site extravasation | 12.17 | 9.99 | 44 | 165235 | 10284 | 90452884 |
| Haemodynamic instability | 12.17 | 9.99 | 48 | 165231 | 11691 | 90451477 |
| BRASH syndrome | 12.08 | 9.99 | 16 | 165263 | 1863 | 90461305 |
| Bilirubin conjugated increased | 12.06 | 9.99 | 21 | 165258 | 3109 | 90460059 |
| Lymphocyte count decreased | 12.05 | 9.99 | 107 | 165172 | 34943 | 90428225 |
| Rales | 12.05 | 9.99 | 59 | 165220 | 15768 | 90447400 |
| Hypoproteinaemia | 12.01 | 9.99 | 21 | 165258 | 3121 | 90460047 |
| Memory impairment | 11.99 | 9.99 | 271 | 165008 | 196973 | 90266195 |
| Cardioactive drug level increased | 11.92 | 9.99 | 18 | 165261 | 2366 | 90460802 |
| Soft tissue infection | 11.91 | 9.99 | 20 | 165259 | 2877 | 90460291 |
| Haematotoxicity | 11.89 | 9.99 | 4 | 165275 | 12531 | 90450637 |
| Urine output decreased | 11.85 | 9.99 | 50 | 165229 | 12553 | 90450615 |
| Product selection error | 11.81 | 9.99 | 7 | 165272 | 274 | 90462894 |
| Anaemia folate deficiency | 11.81 | 9.99 | 9 | 165270 | 537 | 90462631 |
| Foetal heart rate disorder | 11.79 | 9.99 | 6 | 165273 | 173 | 90462995 |
| Infusion site necrosis | 11.79 | 9.99 | 5 | 165274 | 94 | 90463074 |
| Abortion incomplete complicated | 11.78 | 9.99 | 3 | 165276 | 9 | 90463159 |
| Occult blood positive | 11.78 | 9.99 | 24 | 165255 | 3999 | 90459169 |
| Electrocardiogram U wave present | 11.69 | 9.99 | 5 | 165274 | 96 | 90463072 |
| Premature baby | 11.62 | 9.99 | 82 | 165197 | 24995 | 90438173 |
| Infantile apnoea | 11.60 | 9.99 | 13 | 165266 | 1274 | 90461894 |
| Systemic inflammatory response syndrome | 11.58 | 9.99 | 32 | 165247 | 6484 | 90456684 |
| Ageusia | 11.58 | 9.99 | 59 | 165220 | 16017 | 90447151 |
| Electrocardiogram Q wave abnormal | 11.49 | 9.99 | 6 | 165273 | 183 | 90462985 |
| Ischaemia | 11.47 | 9.99 | 28 | 165251 | 5267 | 90457901 |
| Blood aldosterone abnormal | 11.46 | 9.99 | 4 | 165275 | 43 | 90463125 |
| Vascular access malfunction | 11.46 | 9.99 | 4 | 165275 | 43 | 90463125 |
| Impaired work ability | 11.44 | 9.99 | 11 | 165268 | 19315 | 90443853 |
| Cardiac disorder | 11.40 | 9.99 | 156 | 165123 | 56716 | 90406452 |
| Neutropenic sepsis | 11.34 | 9.99 | 64 | 165215 | 18066 | 90445102 |
| Catheter site extravasation | 11.33 | 9.99 | 8 | 165271 | 424 | 90462744 |
| Injection site pruritus | 11.31 | 9.99 | 55 | 165224 | 53779 | 90409389 |
| Heart rate abnormal | 11.29 | 9.99 | 30 | 165249 | 5941 | 90457227 |
| Intestinal polyp | 11.23 | 9.99 | 14 | 165265 | 1535 | 90461633 |
| Arteriovenous malformation | 11.19 | 9.99 | 14 | 165265 | 1541 | 90461627 |
| Lymphangiectasia intestinal | 11.14 | 9.99 | 4 | 165275 | 47 | 90463121 |
| Aortic valve disease | 11.13 | 9.99 | 13 | 165266 | 1333 | 90461835 |
| Ischaemic hepatitis | 11.11 | 9.99 | 19 | 165260 | 2774 | 90460394 |
| Wrong product administered | 11.10 | 9.99 | 35 | 165244 | 7630 | 90455538 |
| Spondylitis | 11.09 | 9.99 | 6 | 165273 | 14172 | 90448996 |
| Tumour lysis syndrome | 11.08 | 9.99 | 45 | 165234 | 11107 | 90452061 |
| Abdominal wall haematoma | 11.03 | 9.99 | 21 | 165258 | 3331 | 90459837 |
| Cytotoxic oedema | 11.03 | 9.99 | 6 | 165273 | 199 | 90462969 |
| Affect lability | 11.02 | 9.99 | 10 | 165269 | 18053 | 90445115 |
| Retroperitoneal haemorrhage | 11.02 | 9.99 | 20 | 165259 | 3060 | 90460108 |
| Peritoneal cloudy effluent | 11.02 | 9.99 | 7 | 165272 | 311 | 90462857 |
| Deficiency anaemia | 10.99 | 9.99 | 4 | 165275 | 49 | 90463119 |
| Lung consolidation | 10.92 | 9.99 | 26 | 165253 | 4814 | 90458354 |
| Retinal ischaemia | 10.88 | 9.99 | 8 | 165271 | 452 | 90462716 |
| Sedation complication | 10.80 | 9.99 | 9 | 165270 | 16935 | 90446233 |
| Splenic injury | 10.79 | 9.99 | 6 | 165273 | 208 | 90462960 |
| Pruritus | 10.73 | 9.99 | 846 | 164433 | 540679 | 89922489 |
| Electrocardiogram ST segment abnormal | 10.73 | 9.99 | 12 | 165267 | 1174 | 90461994 |
| Intentional product misuse | 10.69 | 9.99 | 108 | 165171 | 89496 | 90373672 |
| Restrictive cardiomyopathy | 10.68 | 9.99 | 7 | 165272 | 328 | 90462840 |
| Tendonitis | 10.64 | 9.99 | 14 | 165265 | 21358 | 90441810 |
| Vitamin B1 deficiency | 10.59 | 9.99 | 8 | 165271 | 471 | 90462697 |
| Supraventricular extrasystoles | 10.54 | 9.99 | 27 | 165252 | 5230 | 90457938 |
| Staphylococcus test positive | 10.52 | 9.99 | 24 | 165255 | 4321 | 90458847 |
| Tracheal obstruction | 10.52 | 9.99 | 5 | 165274 | 124 | 90463044 |
| Complication of device insertion | 10.49 | 9.99 | 3 | 165276 | 10433 | 90452735 |
| Acute myeloid leukaemia | 10.46 | 9.99 | 69 | 165210 | 20571 | 90442597 |
| Device difficult to use | 10.34 | 9.99 | 10 | 165269 | 17515 | 90445653 |
| Electrocardiogram P wave abnormal | 10.31 | 9.99 | 6 | 165273 | 227 | 90462941 |
| Cardiac amyloidosis | 10.27 | 9.99 | 11 | 165268 | 1025 | 90462143 |
| Vulvovaginal mycotic infection | 10.24 | 9.99 | 30 | 165249 | 6284 | 90456884 |
| Neonatal hyponatraemia | 10.19 | 9.99 | 4 | 165275 | 61 | 90463107 |
| Cerebral haemorrhage | 10.18 | 9.99 | 102 | 165177 | 34420 | 90428748 |
| Electrocardiogram QRS complex prolonged | 10.14 | 9.99 | 33 | 165246 | 7315 | 90455853 |
| Congestive cardiomyopathy | 10.13 | 9.99 | 33 | 165246 | 7321 | 90455847 |
| Colitis ischaemic | 10.11 | 9.99 | 47 | 165232 | 12299 | 90450869 |
| Sinus node dysfunction | 10.04 | 9.99 | 27 | 165252 | 5385 | 90457783 |
| Diuretic therapy | 10.00 | 9.99 | 5 | 165274 | 139 | 90463029 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myelosuppression | 228.13 | 10.54 | 380 | 104787 | 40081 | 42476087 |
| Appendicolith | 214.40 | 10.54 | 212 | 104955 | 13244 | 42502924 |
| Hypokalaemia | 207.30 | 10.54 | 510 | 104657 | 71211 | 42444957 |
| Drug ineffective | 192.17 | 10.54 | 853 | 104314 | 629344 | 41886824 |
| Cardiogenic shock | 189.35 | 10.54 | 326 | 104841 | 35314 | 42480854 |
| Appendicitis | 163.56 | 10.54 | 227 | 104940 | 20386 | 42495782 |
| Drug abuse | 159.91 | 10.54 | 32 | 105135 | 104739 | 42411429 |
| Ventricular fibrillation | 143.84 | 10.54 | 263 | 104904 | 29860 | 42486308 |
| Ascites | 142.99 | 10.54 | 383 | 104784 | 56295 | 42459873 |
| Abdominal distension | 138.91 | 10.54 | 441 | 104726 | 71294 | 42444874 |
| Sepsis | 118.71 | 10.54 | 870 | 104297 | 198464 | 42317704 |
| Cardiac failure congestive | 115.06 | 10.54 | 467 | 104700 | 85135 | 42431033 |
| Hyperkalaemia | 101.11 | 10.54 | 430 | 104737 | 80028 | 42436140 |
| Blood phosphorus increased | 100.96 | 10.54 | 139 | 105028 | 12386 | 42503782 |
| Hyperphosphataemia | 99.87 | 10.54 | 141 | 105026 | 12863 | 42503305 |
| Stress | 90.34 | 10.54 | 277 | 104890 | 43935 | 42472233 |
| Hypophosphataemia | 88.98 | 10.54 | 174 | 104993 | 20771 | 42495397 |
| Heparin-induced thrombocytopenia | 88.89 | 10.54 | 95 | 105072 | 6502 | 42509666 |
| Multiple organ dysfunction syndrome | 86.68 | 10.54 | 470 | 104697 | 96565 | 42419603 |
| Hypotension | 84.41 | 10.54 | 989 | 104178 | 256642 | 42259526 |
| Hyponatraemia | 81.09 | 10.54 | 477 | 104690 | 100985 | 42415183 |
| Myasthenia gravis | 80.98 | 10.54 | 144 | 105023 | 15993 | 42500175 |
| Therapeutic product effect incomplete | 80.63 | 10.54 | 37 | 105130 | 70902 | 42445266 |
| Sleep disorder therapy | 75.31 | 10.54 | 89 | 105078 | 6805 | 42509363 |
| Analgesic therapy | 72.56 | 10.54 | 85 | 105082 | 6439 | 42509729 |
| Atrial fibrillation | 71.73 | 10.54 | 589 | 104578 | 139004 | 42377164 |
| Off label use | 69.77 | 10.54 | 1133 | 104034 | 637202 | 41878966 |
| Toxicity to various agents | 68.21 | 10.54 | 312 | 104855 | 228824 | 42287344 |
| Treatment failure | 67.62 | 10.54 | 35 | 105132 | 62589 | 42453579 |
| Activated partial thromboplastin time prolonged | 66.20 | 10.54 | 131 | 105036 | 15772 | 42500396 |
| Bacterial infection | 65.89 | 10.54 | 184 | 104983 | 27695 | 42488473 |
| Cytokine release syndrome | 64.68 | 10.54 | 249 | 104918 | 44278 | 42471890 |
| Blood potassium decreased | 64.25 | 10.54 | 150 | 105017 | 20234 | 42495934 |
| Drug therapy | 64.20 | 10.54 | 79 | 105088 | 6301 | 42509867 |
| Oedema peripheral | 58.91 | 10.54 | 553 | 104614 | 135523 | 42380645 |
| Blood uric acid increased | 58.71 | 10.54 | 123 | 105044 | 15424 | 42500744 |
| Tachypnoea | 58.28 | 10.54 | 150 | 105017 | 21512 | 42494656 |
| Aortic stenosis | 57.30 | 10.54 | 88 | 105079 | 8657 | 42507511 |
| Hypervolaemia | 56.00 | 10.54 | 154 | 105013 | 22971 | 42493197 |
| Suicide attempt | 55.65 | 10.54 | 22 | 105145 | 46078 | 42470090 |
| Arthralgia | 54.97 | 10.54 | 290 | 104877 | 204948 | 42311220 |
| Chronic obstructive pulmonary disease | 53.18 | 10.54 | 301 | 104866 | 62813 | 42453355 |
| Anaemia | 50.12 | 10.54 | 970 | 104197 | 279308 | 42236860 |
| Lung consolidation | 49.21 | 10.54 | 71 | 105096 | 6606 | 42509562 |
| Antacid therapy | 48.42 | 10.54 | 59 | 105108 | 4658 | 42511510 |
| Dyspnoea | 48.12 | 10.54 | 1430 | 103737 | 441191 | 42074977 |
| Incorrect route of product administration | 46.61 | 10.54 | 149 | 105018 | 24156 | 42492012 |
| Cardiac failure | 46.60 | 10.54 | 435 | 104732 | 106421 | 42409747 |
| Blood urea increased | 46.49 | 10.54 | 182 | 104985 | 32611 | 42483557 |
| White blood cell count decreased | 46.44 | 10.54 | 446 | 104721 | 109950 | 42406218 |
| Soft tissue mass | 44.61 | 10.54 | 29 | 105138 | 983 | 42515185 |
| Injection site pain | 44.61 | 10.54 | 46 | 105121 | 57752 | 42458416 |
| Acute kidney injury | 44.39 | 10.54 | 1203 | 103964 | 366134 | 42150034 |
| Incision site pain | 44.08 | 10.54 | 37 | 105130 | 1866 | 42514302 |
| Rheumatoid arthritis | 43.94 | 10.54 | 25 | 105142 | 42415 | 42473753 |
| Spinal muscular atrophy | 43.42 | 10.54 | 21 | 105146 | 395 | 42515773 |
| Gout | 43.31 | 10.54 | 160 | 105007 | 27895 | 42488273 |
| Intentional product use issue | 43.21 | 10.54 | 69 | 105098 | 71764 | 42444404 |
| Rales | 42.82 | 10.54 | 90 | 105077 | 11310 | 42504858 |
| Loss of personal independence in daily activities | 42.75 | 10.54 | 36 | 105131 | 49780 | 42466388 |
| Hypoglycaemia | 42.49 | 10.54 | 273 | 104894 | 59581 | 42456587 |
| Iron deficiency | 42.33 | 10.54 | 88 | 105079 | 10973 | 42505195 |
| Swelling | 41.87 | 10.54 | 255 | 104912 | 54630 | 42461538 |
| Blood cholesterol increased | 41.70 | 10.54 | 153 | 105014 | 26588 | 42489580 |
| Multimorbidity | 41.67 | 10.54 | 27 | 105140 | 910 | 42515258 |
| Psoriasis | 39.45 | 10.54 | 37 | 105130 | 48567 | 42467601 |
| Sedation | 37.68 | 10.54 | 14 | 105153 | 30461 | 42485707 |
| Headache | 37.31 | 10.54 | 394 | 104773 | 238975 | 42277193 |
| Drug resistance | 37.17 | 10.54 | 19 | 105148 | 34229 | 42481939 |
| International normalised ratio increased | 36.87 | 10.54 | 224 | 104943 | 47944 | 42468224 |
| Hyperlipidaemia | 36.02 | 10.54 | 126 | 105041 | 21390 | 42494778 |
| Administration site extravasation | 36.01 | 10.54 | 23 | 105144 | 756 | 42515412 |
| Toxic epidermal necrolysis | 35.94 | 10.54 | 146 | 105021 | 26604 | 42489564 |
| Oesophageal perforation | 34.99 | 10.54 | 27 | 105140 | 1206 | 42514962 |
| Neuralgia | 34.47 | 10.54 | 140 | 105027 | 25507 | 42490661 |
| Blood calcium increased | 34.41 | 10.54 | 69 | 105098 | 8385 | 42507783 |
| Constipation | 34.35 | 10.54 | 577 | 104590 | 161714 | 42354454 |
| Pneumonia | 33.45 | 10.54 | 1315 | 103852 | 420834 | 42095334 |
| Hypernatraemia | 32.90 | 10.54 | 75 | 105092 | 9957 | 42506211 |
| Neutrophil count decreased | 32.74 | 10.54 | 268 | 104899 | 63147 | 42453021 |
| Suicidal ideation | 32.15 | 10.54 | 43 | 105124 | 48118 | 42468050 |
| Superinfection | 32.07 | 10.54 | 38 | 105129 | 2913 | 42513255 |
| Meningitis aseptic | 32.07 | 10.54 | 47 | 105120 | 4435 | 42511733 |
| Right ventricular failure | 31.97 | 10.54 | 72 | 105095 | 9483 | 42506685 |
| Ulcer | 30.80 | 10.54 | 100 | 105067 | 16341 | 42499827 |
| Burkholderia test positive | 29.81 | 10.54 | 23 | 105144 | 1027 | 42515141 |
| Motor neurone disease | 29.62 | 10.54 | 18 | 105149 | 541 | 42515627 |
| Dehydration | 29.61 | 10.54 | 503 | 104664 | 141264 | 42374904 |
| End stage renal disease | 29.49 | 10.54 | 99 | 105068 | 16459 | 42499709 |
| Diaphragmatic spasm | 29.42 | 10.54 | 11 | 105156 | 105 | 42516063 |
| Platelet count decreased | 29.42 | 10.54 | 493 | 104674 | 138088 | 42378080 |
| Lung infiltration | 28.89 | 10.54 | 88 | 105079 | 13901 | 42502267 |
| Anticoagulant therapy | 28.82 | 10.54 | 45 | 105122 | 4490 | 42511678 |
| Respiratory failure | 28.00 | 10.54 | 458 | 104709 | 127674 | 42388494 |
| Aggression | 27.92 | 10.54 | 41 | 105126 | 44122 | 42472046 |
| Dry mouth | 27.74 | 10.54 | 181 | 104986 | 39698 | 42476470 |
| Stoma closure | 27.55 | 10.54 | 14 | 105153 | 294 | 42515874 |
| Blood creatinine increased | 27.40 | 10.54 | 402 | 104765 | 109601 | 42406567 |
| Pleural effusion | 27.40 | 10.54 | 363 | 104804 | 96803 | 42419365 |
| Serotonin syndrome | 27.07 | 10.54 | 15 | 105152 | 25830 | 42490338 |
| Vasoplegia syndrome | 26.91 | 10.54 | 33 | 105134 | 2622 | 42513546 |
| Hepatic cytolysis | 26.68 | 10.54 | 134 | 105033 | 26710 | 42489458 |
| Bone marrow failure | 26.67 | 10.54 | 156 | 105011 | 32937 | 42483231 |
| Abdominal pain | 26.51 | 10.54 | 636 | 104531 | 189835 | 42326333 |
| Total lung capacity decreased | 26.36 | 10.54 | 38 | 105129 | 3532 | 42512636 |
| Renal phospholipidosis | 26.26 | 10.54 | 11 | 105156 | 145 | 42516023 |
| Blood pressure fluctuation | 26.25 | 10.54 | 17 | 105150 | 26891 | 42489277 |
| Acute respiratory failure | 26.20 | 10.54 | 175 | 104992 | 38683 | 42477485 |
| Fluid retention | 26.10 | 10.54 | 150 | 105017 | 31469 | 42484699 |
| Therapeutic product effect decreased | 26.09 | 10.54 | 35 | 105132 | 39115 | 42477053 |
| Gastrointestinal haemorrhage | 25.87 | 10.54 | 361 | 104806 | 97365 | 42418803 |
| Mental status changes | 25.65 | 10.54 | 185 | 104982 | 41930 | 42474238 |
| Asthenia | 25.65 | 10.54 | 889 | 104278 | 279904 | 42236264 |
| Faecal volume decreased | 25.59 | 10.54 | 12 | 105155 | 210 | 42515958 |
| Thrombosis | 25.52 | 10.54 | 270 | 104897 | 68241 | 42447927 |
| Glomerular filtration rate | 25.49 | 10.54 | 10 | 105157 | 110 | 42516058 |
| Infusion site necrosis | 25.40 | 10.54 | 7 | 105160 | 21 | 42516147 |
| Pulse absent | 24.99 | 10.54 | 51 | 105116 | 6276 | 42509892 |
| Urticaria | 24.95 | 10.54 | 96 | 105071 | 73940 | 42442228 |
| Intentional self-injury | 24.56 | 10.54 | 4 | 105163 | 15198 | 42500970 |
| Bronchopulmonary aspergillosis allergic | 24.32 | 10.54 | 42 | 105125 | 4556 | 42511612 |
| Drug reaction with eosinophilia and systemic symptoms | 23.83 | 10.54 | 42 | 105125 | 42033 | 42474135 |
| Arthritis | 23.81 | 10.54 | 42 | 105125 | 42023 | 42474145 |
| Product use issue | 23.69 | 10.54 | 103 | 105064 | 76648 | 42439520 |
| Lymphocyte count decreased | 23.66 | 10.54 | 133 | 105034 | 27676 | 42488492 |
| Myalgia | 23.38 | 10.54 | 140 | 105027 | 95940 | 42420228 |
| Inappropriate schedule of product administration | 23.20 | 10.54 | 140 | 105027 | 95762 | 42420406 |
| Supraventricular extrasystoles | 23.06 | 10.54 | 38 | 105129 | 3968 | 42512200 |
| Drug dependence | 22.62 | 10.54 | 23 | 105144 | 29071 | 42487097 |
| Haemoglobin decreased | 22.43 | 10.54 | 455 | 104712 | 132016 | 42384152 |
| Obstructive airways disorder | 22.36 | 10.54 | 17 | 105150 | 24742 | 42491426 |
| Blood chloride decreased | 22.15 | 10.54 | 38 | 105129 | 4101 | 42512067 |
| General physical health deterioration | 21.94 | 10.54 | 508 | 104659 | 150738 | 42365430 |
| Anxiety | 21.91 | 10.54 | 187 | 104980 | 118373 | 42397795 |
| Therapy partial responder | 21.89 | 10.54 | 11 | 105156 | 20010 | 42496158 |
| Disturbance in attention | 21.68 | 10.54 | 25 | 105142 | 29841 | 42486327 |
| Pulmonary hypertension | 21.58 | 10.54 | 115 | 105052 | 23454 | 42492714 |
| Bacteroides infection | 21.28 | 10.54 | 29 | 105138 | 2558 | 42513610 |
| Insomnia | 21.20 | 10.54 | 188 | 104979 | 118065 | 42398103 |
| Lymphadenectomy | 21.19 | 10.54 | 14 | 105153 | 488 | 42515680 |
| Mobility decreased | 21.14 | 10.54 | 34 | 105133 | 35272 | 42480896 |
| Foetal disorder | 21.00 | 10.54 | 19 | 105148 | 1060 | 42515108 |
| Blood bilirubin increased | 20.97 | 10.54 | 177 | 104990 | 42075 | 42474093 |
| Therapeutic response shortened | 20.95 | 10.54 | 4 | 105163 | 13550 | 42502618 |
| Procalcitonin decreased | 20.70 | 10.54 | 11 | 105156 | 254 | 42515914 |
| Prostate cancer | 20.68 | 10.54 | 50 | 105117 | 44593 | 42471575 |
| Joint swelling | 20.56 | 10.54 | 92 | 105075 | 67930 | 42448238 |
| Increased bronchial secretion | 20.37 | 10.54 | 27 | 105140 | 2319 | 42513849 |
| Psoriatic arthropathy | 20.26 | 10.54 | 19 | 105148 | 24948 | 42491220 |
| Disease complication | 20.26 | 10.54 | 31 | 105136 | 3039 | 42513129 |
| Eosinophil percentage decreased | 20.25 | 10.54 | 11 | 105156 | 266 | 42515902 |
| Angioedema | 20.13 | 10.54 | 47 | 105120 | 42430 | 42473738 |
| Blood creatine decreased | 20.10 | 10.54 | 11 | 105156 | 270 | 42515898 |
| Congenital hiatus hernia | 20.07 | 10.54 | 46 | 105121 | 6128 | 42510040 |
| Pulmonary arterial hypertension | 20.03 | 10.54 | 63 | 105104 | 10124 | 42506044 |
| Compartment syndrome | 20.02 | 10.54 | 32 | 105135 | 3257 | 42512911 |
| Sleep disorder due to a general medical condition | 19.98 | 10.54 | 9 | 105158 | 17444 | 42498724 |
| Ventricular tachycardia | 19.84 | 10.54 | 135 | 105032 | 30025 | 42486143 |
| Red blood cells urine positive | 19.78 | 10.54 | 24 | 105143 | 1886 | 42514282 |
| Lower respiratory tract infection bacterial | 19.71 | 10.54 | 14 | 105153 | 550 | 42515618 |
| Pneumococcal sepsis | 19.68 | 10.54 | 21 | 105146 | 1434 | 42514734 |
| Troponin T increased | 19.67 | 10.54 | 29 | 105138 | 2751 | 42513417 |
| Troponin increased | 19.54 | 10.54 | 96 | 105071 | 18966 | 42497202 |
| Ventricular extrasystoles | 19.53 | 10.54 | 75 | 105092 | 13315 | 42502853 |
| Neutropenia neonatal | 19.50 | 10.54 | 17 | 105150 | 903 | 42515265 |
| Electrocardiogram T wave amplitude decreased | 19.47 | 10.54 | 12 | 105155 | 370 | 42515798 |
| Haemoglobin increased | 19.43 | 10.54 | 41 | 105126 | 5165 | 42511003 |
| Blood test abnormal | 19.41 | 10.54 | 73 | 105094 | 12833 | 42503335 |
| Atrial flutter | 19.22 | 10.54 | 89 | 105078 | 17162 | 42499006 |
| Blood pressure increased | 19.18 | 10.54 | 160 | 105007 | 101768 | 42414400 |
| Product dose omission issue | 19.10 | 10.54 | 267 | 104900 | 154098 | 42362070 |
| Frequent bowel movements | 18.95 | 10.54 | 15 | 105152 | 21392 | 42494776 |
| Bronchial disorder | 18.60 | 10.54 | 20 | 105147 | 1378 | 42514790 |
| Aspartate aminotransferase increased | 18.43 | 10.54 | 280 | 104887 | 76883 | 42439285 |
| Transient aphasia | 18.35 | 10.54 | 14 | 105153 | 615 | 42515553 |
| Sputum increased | 18.20 | 10.54 | 30 | 105137 | 3133 | 42513035 |
| Product substitution issue | 18.18 | 10.54 | 3 | 105164 | 11287 | 42504881 |
| Peri-implantitis | 17.99 | 10.54 | 8 | 105159 | 123 | 42516045 |
| Metabolic alkalosis | 17.97 | 10.54 | 24 | 105143 | 2077 | 42514091 |
| Rash | 17.77 | 10.54 | 534 | 104633 | 276420 | 42239748 |
| Pruritus | 17.60 | 10.54 | 344 | 104823 | 188427 | 42327741 |
| Haematotoxicity | 17.51 | 10.54 | 3 | 105164 | 10982 | 42505186 |
| Therapeutic response decreased | 17.50 | 10.54 | 41 | 105126 | 36971 | 42479197 |
| Depression | 17.44 | 10.54 | 183 | 104984 | 111180 | 42404988 |
| Salivary hypersecretion | 17.41 | 10.54 | 3 | 105164 | 10940 | 42505228 |
| Atelectasis | 17.41 | 10.54 | 94 | 105073 | 19267 | 42496901 |
| Resuscitation | 17.40 | 10.54 | 22 | 105145 | 1803 | 42514365 |
| Arthropathy | 17.26 | 10.54 | 29 | 105138 | 29568 | 42486600 |
| Oropharyngeal pain | 17.13 | 10.54 | 51 | 105116 | 42459 | 42473709 |
| Oedema | 17.11 | 10.54 | 200 | 104967 | 51801 | 42464367 |
| Drug interaction | 17.08 | 10.54 | 515 | 104652 | 266484 | 42249684 |
| Metabolic disorder | 17.06 | 10.54 | 37 | 105130 | 4751 | 42511417 |
| Pleuritic pain | 17.00 | 10.54 | 47 | 105120 | 7030 | 42509138 |
| Febrile neutropenia | 16.94 | 10.54 | 588 | 104579 | 185115 | 42331053 |
| Overdose | 16.88 | 10.54 | 172 | 104995 | 105092 | 42411076 |
| Altered state of consciousness | 16.75 | 10.54 | 29 | 105138 | 29230 | 42486938 |
| Endotracheal intubation | 16.75 | 10.54 | 32 | 105135 | 3753 | 42512415 |
| Granulocyte count decreased | 16.70 | 10.54 | 20 | 105147 | 1550 | 42514618 |
| Methaemoglobinaemia | 16.59 | 10.54 | 41 | 105126 | 5733 | 42510435 |
| Atrial enlargement | 16.53 | 10.54 | 14 | 105153 | 715 | 42515453 |
| Peritoneal cloudy effluent | 16.51 | 10.54 | 11 | 105156 | 389 | 42515779 |
| Blood immunoglobulin M abnormal | 16.47 | 10.54 | 7 | 105160 | 96 | 42516072 |
| Transplant failure | 16.45 | 10.54 | 33 | 105134 | 4011 | 42512157 |
| Diabetes mellitus | 16.32 | 10.54 | 223 | 104944 | 59864 | 42456304 |
| Blood immunoglobulin G abnormal | 16.27 | 10.54 | 7 | 105160 | 99 | 42516069 |
| Hyperglycaemia | 16.27 | 10.54 | 179 | 104988 | 45680 | 42470488 |
| Type IIa hyperlipidaemia | 16.24 | 10.54 | 10 | 105157 | 308 | 42515860 |
| Chills | 16.22 | 10.54 | 324 | 104843 | 93742 | 42422426 |
| Cardiomegaly | 16.17 | 10.54 | 83 | 105084 | 16683 | 42499485 |
| Visual acuity reduced | 15.91 | 10.54 | 12 | 105155 | 17538 | 42498630 |
| Heparin-induced thrombocytopenia test | 15.83 | 10.54 | 8 | 105159 | 166 | 42516002 |
| Psychotic disorder | 15.79 | 10.54 | 30 | 105137 | 29178 | 42486990 |
| Cardiomyopathy | 15.76 | 10.54 | 91 | 105076 | 19119 | 42497049 |
| Hospitalisation | 15.70 | 10.54 | 113 | 105054 | 74217 | 42441951 |
| Vertigo | 15.49 | 10.54 | 39 | 105128 | 34308 | 42481860 |
| Immune effector cell-associated neurotoxicity syndrome | 15.48 | 10.54 | 55 | 105112 | 9406 | 42506762 |
| Cardiac arrest | 15.48 | 10.54 | 366 | 104801 | 108954 | 42407214 |
| Glomerular filtration rate abnormal | 15.44 | 10.54 | 17 | 105150 | 1203 | 42514965 |
| Blood albumin decreased | 15.38 | 10.54 | 77 | 105090 | 15325 | 42500843 |
| Polyneuropathy | 15.38 | 10.54 | 14 | 105153 | 18647 | 42497521 |
| Miosis | 15.29 | 10.54 | 7 | 105160 | 13439 | 42502729 |
| Bradycardia | 15.26 | 10.54 | 296 | 104871 | 85188 | 42430980 |
| Cognitive disorder | 15.26 | 10.54 | 39 | 105128 | 34133 | 42482035 |
| Aortic valve calcification | 15.23 | 10.54 | 12 | 105155 | 553 | 42515615 |
| Blood urea decreased | 15.11 | 10.54 | 18 | 105149 | 1388 | 42514780 |
| Tumour lysis syndrome | 14.91 | 10.54 | 100 | 105067 | 22131 | 42494037 |
| Injection site swelling | 14.89 | 10.54 | 12 | 105155 | 16961 | 42499207 |
| Hypovolaemia | 14.88 | 10.54 | 62 | 105105 | 11423 | 42504745 |
| Intentional overdose | 14.71 | 10.54 | 71 | 105096 | 51385 | 42464783 |
| Breath sounds abnormal | 14.68 | 10.54 | 64 | 105103 | 12029 | 42504139 |
| Ileus | 14.63 | 10.54 | 89 | 105078 | 19050 | 42497118 |
| Hyperpyrexia | 14.54 | 10.54 | 29 | 105138 | 3511 | 42512657 |
| Blood sodium abnormal | 14.50 | 10.54 | 12 | 105155 | 593 | 42515575 |
| Sensory integrative dysfunction | 14.49 | 10.54 | 5 | 105162 | 37 | 42516131 |
| Shoshin beriberi | 14.33 | 10.54 | 6 | 105161 | 79 | 42516089 |
| International normalised ratio fluctuation | 14.31 | 10.54 | 17 | 105150 | 1307 | 42514861 |
| Arrhythmia supraventricular | 14.24 | 10.54 | 18 | 105149 | 1475 | 42514693 |
| Pain in extremity | 14.16 | 10.54 | 274 | 104893 | 150330 | 42365838 |
| Nightmare | 14.13 | 10.54 | 25 | 105142 | 24987 | 42491181 |
| Lymphoma | 14.03 | 10.54 | 9 | 105158 | 14312 | 42501856 |
| Dystonia | 14.02 | 10.54 | 7 | 105160 | 12783 | 42503385 |
| Chest X-ray abnormal | 14.01 | 10.54 | 33 | 105134 | 4475 | 42511693 |
| Migraine | 13.82 | 10.54 | 26 | 105141 | 25388 | 42490780 |
| Product use in unapproved indication | 13.79 | 10.54 | 348 | 104819 | 184108 | 42332060 |
| Vasculitis | 13.78 | 10.54 | 15 | 105152 | 18379 | 42497789 |
| Prothrombin time prolonged | 13.78 | 10.54 | 53 | 105114 | 9416 | 42506752 |
| Therapeutic product effect prolonged | 13.74 | 10.54 | 9 | 105158 | 309 | 42515859 |
| Sinusitis | 13.67 | 10.54 | 65 | 105102 | 47227 | 42468941 |
| Eczema | 13.66 | 10.54 | 41 | 105126 | 34045 | 42482123 |
| Respiratory tract infection bacterial | 13.63 | 10.54 | 20 | 105147 | 1889 | 42514279 |
| Red cell distribution width increased | 13.63 | 10.54 | 43 | 105124 | 6921 | 42509247 |
| Vomiting | 13.55 | 10.54 | 858 | 104309 | 288865 | 42227303 |
| Depressed mood | 13.55 | 10.54 | 23 | 105144 | 23361 | 42492807 |
| Lymphadenopathy | 13.46 | 10.54 | 40 | 105127 | 33325 | 42482843 |
| Post transplant lymphoproliferative disorder | 13.46 | 10.54 | 3 | 105164 | 9117 | 42507051 |
| Nephropathy toxic | 13.45 | 10.54 | 13 | 105154 | 16825 | 42499343 |
| Hypomagnesaemia | 13.43 | 10.54 | 118 | 105049 | 28370 | 42487798 |
| Exercise tolerance decreased | 13.32 | 10.54 | 39 | 105128 | 6027 | 42510141 |
| Red blood cell sedimentation rate increased | 13.24 | 10.54 | 4 | 105163 | 9920 | 42506248 |
| Enterobacter pneumonia | 13.19 | 10.54 | 11 | 105156 | 550 | 42515618 |
| Tendonitis | 13.18 | 10.54 | 4 | 105163 | 9890 | 42506278 |
| Blood potassium abnormal | 13.17 | 10.54 | 19 | 105148 | 1767 | 42514401 |
| Nasopharyngitis | 13.16 | 10.54 | 138 | 105029 | 83858 | 42432310 |
| Emotional disorder of childhood | 13.08 | 10.54 | 5 | 105162 | 51 | 42516117 |
| Interstitial lung disease | 13.08 | 10.54 | 127 | 105040 | 78335 | 42437833 |
| Squamous cell carcinoma | 12.94 | 10.54 | 8 | 105159 | 12974 | 42503194 |
| Dyskinesia | 12.93 | 10.54 | 27 | 105140 | 25363 | 42490805 |
| Congestive hepatopathy | 12.92 | 10.54 | 22 | 105145 | 2360 | 42513808 |
| Ischaemic cerebral infarction | 12.89 | 10.54 | 18 | 105149 | 1625 | 42514543 |
| Alveolar lung disease | 12.86 | 10.54 | 10 | 105157 | 452 | 42515716 |
| Cytomegalovirus infection | 12.84 | 10.54 | 39 | 105128 | 32267 | 42483901 |
| Mood swings | 12.83 | 10.54 | 3 | 105164 | 8823 | 42507345 |
| Cardiovascular disorder | 12.78 | 10.54 | 66 | 105101 | 13299 | 42502869 |
| Electrolyte imbalance | 12.75 | 10.54 | 79 | 105088 | 17022 | 42499146 |
| Herpes zoster | 12.72 | 10.54 | 51 | 105116 | 38826 | 42477342 |
| Osmotic demyelination syndrome | 12.63 | 10.54 | 14 | 105153 | 998 | 42515170 |
| Hepatotoxicity | 12.62 | 10.54 | 27 | 105140 | 25140 | 42491028 |
| Hypoxia | 12.57 | 10.54 | 242 | 104925 | 69544 | 42446624 |
| Inflammatory marker increased | 12.57 | 10.54 | 41 | 105126 | 6715 | 42509453 |
| Photosensitivity reaction | 12.42 | 10.54 | 8 | 105159 | 12694 | 42503474 |
| Vocal cord paralysis | 12.36 | 10.54 | 15 | 105152 | 1179 | 42514989 |
| Catheter site extravasation | 12.36 | 10.54 | 7 | 105160 | 184 | 42515984 |
| Product storage error | 12.36 | 10.54 | 6 | 105161 | 11134 | 42505034 |
| Scrotal oedema | 12.29 | 10.54 | 19 | 105148 | 1880 | 42514288 |
| Amnesia | 12.28 | 10.54 | 33 | 105134 | 28404 | 42487764 |
| Posthaemorrhagic hydrocephalus | 12.07 | 10.54 | 6 | 105161 | 120 | 42516048 |
| Dry skin | 11.98 | 10.54 | 70 | 105097 | 48268 | 42467900 |
| Wrong patient | 11.95 | 10.54 | 11 | 105156 | 628 | 42515540 |
| Right ventricular dysfunction | 11.90 | 10.54 | 16 | 105151 | 1393 | 42514775 |
| Respiratory alkalosis | 11.86 | 10.54 | 21 | 105146 | 2323 | 42513845 |
| Pulmonary oedema | 11.84 | 10.54 | 191 | 104976 | 53081 | 42463087 |
| Cardiac pacemaker evaluation | 11.81 | 10.54 | 6 | 105161 | 126 | 42516042 |
| Intracardiac mass | 11.80 | 10.54 | 7 | 105160 | 201 | 42515967 |
| Protein total decreased | 11.79 | 10.54 | 37 | 105130 | 5939 | 42510229 |
| Mental impairment | 11.72 | 10.54 | 8 | 105159 | 12309 | 42503859 |
| Body temperature decreased | 11.66 | 10.54 | 11 | 105156 | 14402 | 42501766 |
| Pain | 11.60 | 10.54 | 490 | 104677 | 244358 | 42271810 |
| Injection site reaction | 11.58 | 10.54 | 13 | 105154 | 15708 | 42500460 |
| Failure to thrive | 11.54 | 10.54 | 50 | 105117 | 9372 | 42506796 |
| Generalised oedema | 11.53 | 10.54 | 71 | 105096 | 15265 | 42500903 |
| Pathogen resistance | 11.49 | 10.54 | 7 | 105160 | 11443 | 42504725 |
| Epididymitis | 11.45 | 10.54 | 24 | 105143 | 3010 | 42513158 |
| Oral blood blister | 11.43 | 10.54 | 4 | 105163 | 31 | 42516137 |
| Pantoea agglomerans infection | 11.42 | 10.54 | 5 | 105162 | 74 | 42516094 |
| Hallucination, auditory | 11.27 | 10.54 | 12 | 105155 | 14852 | 42501316 |
| Dry eye | 11.23 | 10.54 | 13 | 105154 | 15493 | 42500675 |
| Catheter site infection | 11.18 | 10.54 | 24 | 105143 | 3059 | 42513109 |
| Aspiration | 11.14 | 10.54 | 79 | 105088 | 17807 | 42498361 |
| Pulmonary interstitial emphysema syndrome | 11.13 | 10.54 | 10 | 105157 | 553 | 42515615 |
| Cortical visual impairment | 11.11 | 10.54 | 4 | 105163 | 34 | 42516134 |
| Plasma cell myeloma | 11.10 | 10.54 | 172 | 104995 | 47406 | 42468762 |
| Peripheral motor neuropathy | 11.10 | 10.54 | 20 | 105147 | 2244 | 42513924 |
| Akathisia | 11.04 | 10.54 | 6 | 105161 | 10445 | 42505723 |
| Pneumocystis jirovecii pneumonia | 11.04 | 10.54 | 29 | 105138 | 25152 | 42491016 |
| Lactobacillus test positive | 11.01 | 10.54 | 4 | 105163 | 35 | 42516133 |
| Poisoning | 11.00 | 10.54 | 12 | 105155 | 14687 | 42501481 |
| Cytomegalovirus infection reactivation | 10.99 | 10.54 | 7 | 105160 | 11171 | 42504997 |
| Thymus hypoplasia | 10.89 | 10.54 | 12 | 105155 | 850 | 42515318 |
| Drug chemical incompatibility | 10.88 | 10.54 | 3 | 105164 | 9 | 42516159 |
| Neoplasm progression | 10.83 | 10.54 | 36 | 105131 | 28964 | 42487204 |
| Alkalosis | 10.83 | 10.54 | 6 | 105161 | 151 | 42516017 |
| Inappropriate antidiuretic hormone secretion | 10.80 | 10.54 | 15 | 105152 | 16526 | 42499642 |
| Pulmonary fibrosis | 10.76 | 10.54 | 32 | 105135 | 26649 | 42489519 |
| Thirst decreased | 10.72 | 10.54 | 4 | 105163 | 38 | 42516130 |
| Lymphoid tissue hypoplasia | 10.71 | 10.54 | 12 | 105155 | 866 | 42515302 |
| Injection site erythema | 10.69 | 10.54 | 21 | 105146 | 20174 | 42495994 |
| Renal tubular acidosis | 10.66 | 10.54 | 22 | 105145 | 2728 | 42513440 |
| Chronic right ventricular failure | 10.65 | 10.54 | 3 | 105164 | 10 | 42516158 |
| Refeeding syndrome | 10.64 | 10.54 | 5 | 105162 | 88 | 42516080 |
| Device related infection | 10.62 | 10.54 | 86 | 105081 | 20193 | 42495975 |
| Bladder cancer | 10.60 | 10.54 | 16 | 105151 | 17031 | 42499137 |
| Hepatocellular injury | 10.59 | 10.54 | 27 | 105140 | 23651 | 42492517 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myelosuppression | 1405.33 | 9.73 | 1324 | 228167 | 93016 | 110266792 |
| Hypokalaemia | 610.13 | 9.73 | 1239 | 228252 | 181209 | 110178599 |
| Pemphigus | 427.70 | 9.73 | 3 | 229488 | 214567 | 110145241 |
| Hand deformity | 426.34 | 9.73 | 5 | 229486 | 218501 | 110141307 |
| Hyperkalaemia | 424.23 | 9.73 | 897 | 228594 | 134899 | 110224909 |
| Systemic lupus erythematosus | 374.99 | 9.73 | 44 | 229447 | 254294 | 110105514 |
| Joint swelling | 341.90 | 9.73 | 252 | 229239 | 442593 | 109917215 |
| Glossodynia | 338.48 | 9.73 | 34 | 229457 | 221970 | 110137838 |
| Duodenal ulcer perforation | 334.29 | 9.73 | 7 | 229484 | 177693 | 110182115 |
| Helicobacter infection | 331.41 | 9.73 | 10 | 229481 | 181867 | 110177941 |
| Cardiac failure congestive | 328.36 | 9.73 | 866 | 228625 | 150134 | 110209674 |
| Sepsis | 324.00 | 9.73 | 1442 | 228049 | 325904 | 110033904 |
| Arthropathy | 313.26 | 9.73 | 103 | 229388 | 287419 | 110072389 |
| Pericarditis | 308.31 | 9.73 | 44 | 229447 | 219070 | 110140738 |
| White blood cell count decreased | 307.53 | 9.73 | 1111 | 228380 | 228279 | 110131529 |
| Wound | 295.11 | 9.73 | 63 | 229428 | 234374 | 110125434 |
| Acute kidney injury | 277.66 | 9.73 | 2259 | 227232 | 633171 | 109726637 |
| Muscle injury | 275.64 | 9.73 | 3 | 229488 | 140804 | 110219004 |
| Anaemia | 274.02 | 9.73 | 2008 | 227483 | 545078 | 109814730 |
| Drug ineffective | 274.00 | 9.73 | 1942 | 227549 | 1518598 | 108841210 |
| Hypotension | 265.93 | 9.73 | 1929 | 227562 | 521920 | 109837888 |
| Rheumatoid arthritis | 260.38 | 9.73 | 149 | 229342 | 299464 | 110060344 |
| Folliculitis | 259.96 | 9.73 | 24 | 229467 | 167629 | 110192179 |
| Irritable bowel syndrome | 253.32 | 9.73 | 24 | 229467 | 164191 | 110195617 |
| Atrial fibrillation | 252.80 | 9.73 | 1045 | 228446 | 228597 | 110131211 |
| Hypervolaemia | 252.40 | 9.73 | 404 | 229087 | 49056 | 110310752 |
| Appendicolith | 247.08 | 9.73 | 218 | 229273 | 14037 | 110345771 |
| Therapeutic product effect decreased | 246.65 | 9.73 | 99 | 229392 | 244217 | 110115591 |
| Cardiogenic shock | 244.23 | 9.73 | 432 | 229059 | 56906 | 110302902 |
| Neutrophil count decreased | 230.46 | 9.73 | 661 | 228830 | 120280 | 110239528 |
| Impaired healing | 227.75 | 9.73 | 63 | 229428 | 196654 | 110163154 |
| Synovitis | 226.00 | 9.73 | 145 | 229346 | 273947 | 110085861 |
| Psoriatic arthropathy | 225.97 | 9.73 | 64 | 229427 | 196697 | 110163111 |
| Alopecia | 223.95 | 9.73 | 256 | 229235 | 364497 | 109995311 |
| Arthralgia | 213.13 | 9.73 | 864 | 228627 | 778768 | 109581040 |
| Contraindicated product administered | 206.51 | 9.73 | 130 | 229361 | 248137 | 110111671 |
| Blood potassium decreased | 204.29 | 9.73 | 387 | 229104 | 53727 | 110306081 |
| Hyponatraemia | 201.15 | 9.73 | 940 | 228551 | 216713 | 110143095 |
| Sleep disorder due to general medical condition, insomnia type | 195.42 | 9.73 | 5 | 229486 | 105638 | 110254170 |
| Ascites | 193.31 | 9.73 | 524 | 228967 | 92284 | 110267524 |
| Ill-defined disorder | 191.63 | 9.73 | 45 | 229446 | 156808 | 110203000 |
| Drug abuse | 190.64 | 9.73 | 65 | 229426 | 177346 | 110182462 |
| Cytokine release syndrome | 189.59 | 9.73 | 438 | 229053 | 69868 | 110289940 |
| Hepatic enzyme increased | 188.64 | 9.73 | 233 | 229258 | 320659 | 110039149 |
| Ventricular fibrillation | 187.32 | 9.73 | 320 | 229171 | 40993 | 110318815 |
| Fibromyalgia | 184.72 | 9.73 | 62 | 229429 | 170847 | 110188961 |
| Treatment failure | 184.18 | 9.73 | 182 | 229309 | 277052 | 110082756 |
| Facet joint syndrome | 181.35 | 9.73 | 4 | 229487 | 96824 | 110262984 |
| Musculoskeletal stiffness | 181.00 | 9.73 | 188 | 229303 | 279634 | 110080174 |
| Appendicitis | 180.05 | 9.73 | 257 | 229234 | 28207 | 110331601 |
| Dehydration | 176.96 | 9.73 | 1088 | 228403 | 278423 | 110081385 |
| Joint range of motion decreased | 174.80 | 9.73 | 23 | 229468 | 121809 | 110237999 |
| Abdominal discomfort | 172.67 | 9.73 | 348 | 229143 | 393510 | 109966298 |
| Intentional product use issue | 171.39 | 9.73 | 157 | 229334 | 247749 | 110112059 |
| C-reactive protein abnormal | 167.00 | 9.73 | 33 | 229458 | 129662 | 110230146 |
| Pneumonia | 166.35 | 9.73 | 2647 | 226844 | 874067 | 109485741 |
| Hypersensitivity | 166.20 | 9.73 | 370 | 229121 | 403628 | 109956180 |
| Bone marrow failure | 162.18 | 9.73 | 366 | 229125 | 57482 | 110302326 |
| Lip dry | 161.56 | 9.73 | 12 | 229479 | 100071 | 110259737 |
| Drug intolerance | 152.37 | 9.73 | 391 | 229100 | 406121 | 109953687 |
| Hypoglycaemia | 151.78 | 9.73 | 558 | 228933 | 115546 | 110244262 |
| Nasopharyngitis | 151.15 | 9.73 | 375 | 229116 | 393986 | 109965822 |
| Acute respiratory failure | 150.83 | 9.73 | 419 | 229072 | 74841 | 110284967 |
| Bursitis | 149.63 | 9.73 | 42 | 229449 | 129876 | 110229932 |
| Respiratory failure | 147.66 | 9.73 | 856 | 228635 | 214476 | 110145332 |
| Inflammation | 147.61 | 9.73 | 111 | 229380 | 193127 | 110166681 |
| Grip strength decreased | 147.52 | 9.73 | 4 | 229487 | 80170 | 110279638 |
| Platelet count decreased | 145.18 | 9.73 | 896 | 228595 | 229547 | 110130261 |
| Discomfort | 143.68 | 9.73 | 140 | 229351 | 214567 | 110145241 |
| Pulmonary hypertension | 136.93 | 9.73 | 333 | 229158 | 54887 | 110304921 |
| Lower respiratory tract infection | 136.14 | 9.73 | 183 | 229308 | 242923 | 110116885 |
| Heparin-induced thrombocytopenia | 135.93 | 9.73 | 142 | 229349 | 11282 | 110348526 |
| Chronic obstructive pulmonary disease | 133.87 | 9.73 | 514 | 228977 | 108644 | 110251164 |
| Hypophosphataemia | 132.35 | 9.73 | 243 | 229248 | 32939 | 110326869 |
| Colitis microscopic | 130.70 | 9.73 | 150 | 229341 | 13244 | 110346564 |
| Vaginal flatulence | 128.74 | 9.73 | 142 | 229349 | 12002 | 110347806 |
| Hypoxia | 128.24 | 9.73 | 571 | 228920 | 128944 | 110230864 |
| Constipation | 126.37 | 9.73 | 1215 | 228276 | 356571 | 110003237 |
| Osteoarthritis | 125.79 | 9.73 | 116 | 229375 | 182507 | 110177301 |
| Type 2 diabetes mellitus | 123.96 | 9.73 | 111 | 229380 | 177121 | 110182687 |
| Blood phosphorus increased | 123.74 | 9.73 | 161 | 229330 | 16179 | 110343629 |
| Gastrointestinal haemorrhage | 123.39 | 9.73 | 673 | 228818 | 164845 | 110194963 |
| Mobility decreased | 122.80 | 9.73 | 189 | 229302 | 237233 | 110122575 |
| Pleural effusion | 121.52 | 9.73 | 706 | 228785 | 177003 | 110182805 |
| Product use issue | 121.28 | 9.73 | 294 | 229197 | 311401 | 110048407 |
| Febrile neutropenia | 121.03 | 9.73 | 1094 | 228397 | 315673 | 110044135 |
| Oedema peripheral | 120.49 | 9.73 | 1125 | 228366 | 327535 | 110032273 |
| Cardiac failure | 120.35 | 9.73 | 733 | 228758 | 186893 | 110172915 |
| Blood urea increased | 119.17 | 9.73 | 315 | 229176 | 54642 | 110305166 |
| Right ventricular failure | 118.93 | 9.73 | 202 | 229289 | 25752 | 110334056 |
| Urticaria | 117.67 | 9.73 | 309 | 229182 | 318548 | 110041260 |
| Night sweats | 117.22 | 9.73 | 66 | 229425 | 133917 | 110225891 |
| Blister | 116.65 | 9.73 | 182 | 229309 | 227194 | 110132614 |
| Dyspnoea | 115.36 | 9.73 | 3058 | 226433 | 1103814 | 109255994 |
| Stomatitis | 114.80 | 9.73 | 243 | 229248 | 269999 | 110089809 |
| Multiple organ dysfunction syndrome | 112.50 | 9.73 | 616 | 228875 | 151094 | 110208714 |
| Radiculopathy | 109.88 | 9.73 | 166 | 229325 | 19170 | 110340638 |
| Cardiac arrest | 109.18 | 9.73 | 741 | 228750 | 196012 | 110163796 |
| Female genital tract fistula | 108.69 | 9.73 | 152 | 229339 | 16367 | 110343441 |
| Rash | 107.98 | 9.73 | 1136 | 228355 | 819828 | 109539980 |
| Proctitis | 107.29 | 9.73 | 153 | 229338 | 16774 | 110343034 |
| Hyperphosphataemia | 106.69 | 9.73 | 150 | 229341 | 16231 | 110343577 |
| Activated partial thromboplastin time prolonged | 102.37 | 9.73 | 174 | 229317 | 22194 | 110337614 |
| Psoriasis | 101.14 | 9.73 | 85 | 229406 | 139908 | 110219900 |
| Blepharospasm | 99.94 | 9.73 | 3 | 229488 | 54848 | 110304960 |
| Infusion related reaction | 99.18 | 9.73 | 430 | 229061 | 380732 | 109979076 |
| International normalised ratio increased | 98.63 | 9.73 | 399 | 229092 | 86373 | 110273435 |
| Macular degeneration | 97.17 | 9.73 | 167 | 229324 | 21492 | 110338316 |
| Pulmonary arterial hypertension | 95.71 | 9.73 | 210 | 229281 | 32358 | 110327450 |
| Pain | 94.92 | 9.73 | 1403 | 228088 | 953552 | 109406256 |
| Sleep disorder therapy | 94.55 | 9.73 | 96 | 229395 | 7375 | 110352433 |
| Wheezing | 94.40 | 9.73 | 247 | 229244 | 254983 | 110104825 |
| Drug hypersensitivity | 94.37 | 9.73 | 554 | 228937 | 453536 | 109906272 |
| Chronic sinusitis | 94.17 | 9.73 | 179 | 229312 | 24905 | 110334903 |
| Peripheral venous disease | 93.55 | 9.73 | 29 | 229462 | 84088 | 110275720 |
| Haemoglobin decreased | 92.42 | 9.73 | 854 | 228637 | 247873 | 110111935 |
| Myasthenia gravis | 91.49 | 9.73 | 162 | 229329 | 21349 | 110338459 |
| Analgesic therapy | 91.10 | 9.73 | 93 | 229398 | 7191 | 110352617 |
| Toxic epidermal necrolysis | 90.15 | 9.73 | 291 | 229200 | 56436 | 110303372 |
| Abdominal distension | 89.24 | 9.73 | 646 | 228845 | 174457 | 110185351 |
| Paraesthesia oral | 88.81 | 9.73 | 208 | 229283 | 33463 | 110326345 |
| Vaginal discharge | 88.24 | 9.73 | 144 | 229347 | 17764 | 110342044 |
| Glaucoma | 87.42 | 9.73 | 163 | 229328 | 22354 | 110337454 |
| Live birth | 86.72 | 9.73 | 19 | 229472 | 69465 | 110290343 |
| Tachypnoea | 86.63 | 9.73 | 227 | 229264 | 39168 | 110320640 |
| Obesity | 84.14 | 9.73 | 67 | 229424 | 113284 | 110246524 |
| Blood creatinine increased | 83.78 | 9.73 | 658 | 228833 | 182231 | 110177577 |
| Lower limb fracture | 83.75 | 9.73 | 26 | 229465 | 75322 | 110284486 |
| Onychomadesis | 81.42 | 9.73 | 3 | 229488 | 45660 | 110314148 |
| Nail disorder | 80.60 | 9.73 | 12 | 229479 | 57923 | 110301885 |
| Gait inability | 80.09 | 9.73 | 99 | 229392 | 136277 | 110223531 |
| Granulocyte count decreased | 79.52 | 9.73 | 66 | 229425 | 3908 | 110355900 |
| Off label use | 79.18 | 9.73 | 2442 | 227049 | 1497743 | 108862065 |
| Road traffic accident | 79.07 | 9.73 | 64 | 229427 | 107334 | 110252474 |
| Pneumonia aspiration | 78.78 | 9.73 | 356 | 229135 | 80877 | 110278931 |
| Drug therapy | 78.58 | 9.73 | 86 | 229405 | 7205 | 110352603 |
| Maternal exposure during pregnancy | 78.19 | 9.73 | 269 | 229222 | 254614 | 110105194 |
| Mental status changes | 77.91 | 9.73 | 339 | 229152 | 75783 | 110284025 |
| Injury | 77.28 | 9.73 | 157 | 229334 | 177108 | 110182700 |
| Pulmonary fibrosis | 76.14 | 9.73 | 60 | 229431 | 101982 | 110257826 |
| Blood bilirubin increased | 75.98 | 9.73 | 336 | 229155 | 75636 | 110284172 |
| Wound infection | 75.48 | 9.73 | 54 | 229437 | 96411 | 110263397 |
| Sinusitis | 74.56 | 9.73 | 339 | 229152 | 296349 | 110063459 |
| Autoimmune disorder | 73.86 | 9.73 | 22 | 229469 | 65461 | 110294347 |
| Hyperlipidaemia | 73.22 | 9.73 | 201 | 229290 | 35647 | 110324161 |
| Pulmonary oedema | 72.79 | 9.73 | 406 | 229085 | 100253 | 110259555 |
| Prescribed overdose | 72.58 | 9.73 | 46 | 229445 | 87535 | 110272273 |
| Bacterial infection | 72.10 | 9.73 | 235 | 229256 | 45801 | 110314007 |
| Arthritis | 71.72 | 9.73 | 150 | 229341 | 167436 | 110192372 |
| Abdominal pain | 71.59 | 9.73 | 1477 | 228014 | 511512 | 109848296 |
| Renal failure | 71.04 | 9.73 | 751 | 228740 | 225823 | 110133985 |
| Gout | 70.72 | 9.73 | 201 | 229290 | 36365 | 110323443 |
| Hypomagnesaemia | 70.52 | 9.73 | 280 | 229211 | 60090 | 110299718 |
| Plasma cell myeloma | 70.41 | 9.73 | 288 | 229203 | 62648 | 110297160 |
| Procedural pain | 70.25 | 9.73 | 197 | 229294 | 35368 | 110324440 |
| Injection site reaction | 69.50 | 9.73 | 50 | 229441 | 89020 | 110270788 |
| Toxicity to various agents | 68.43 | 9.73 | 652 | 228839 | 479903 | 109879905 |
| Hyperglycaemia | 68.17 | 9.73 | 353 | 229138 | 84737 | 110275071 |
| Migraine | 67.44 | 9.73 | 161 | 229330 | 171491 | 110188317 |
| Colitis | 66.37 | 9.73 | 401 | 229090 | 101922 | 110257886 |
| Aspartate aminotransferase increased | 66.01 | 9.73 | 562 | 228929 | 159374 | 110200434 |
| Infection | 65.45 | 9.73 | 461 | 229030 | 361739 | 109998069 |
| Hypernatraemia | 65.40 | 9.73 | 126 | 229365 | 17707 | 110342101 |
| Paraesthesia | 65.34 | 9.73 | 323 | 229168 | 276198 | 110083610 |
| Atrial flutter | 65.22 | 9.73 | 151 | 229340 | 24111 | 110335697 |
| Epilepsy | 65.11 | 9.73 | 67 | 229424 | 100142 | 110259666 |
| Swelling | 64.81 | 9.73 | 444 | 229047 | 350597 | 110009211 |
| Coeliac disease | 64.79 | 9.73 | 7 | 229484 | 43180 | 110316628 |
| Injection site pain | 64.40 | 9.73 | 174 | 229317 | 177748 | 110182060 |
| Pregnancy | 63.65 | 9.73 | 14 | 229477 | 51053 | 110308755 |
| Musculoskeletal pain | 63.27 | 9.73 | 183 | 229308 | 182840 | 110176968 |
| Product use in unapproved indication | 62.84 | 9.73 | 609 | 228882 | 446768 | 109913040 |
| Diverticulitis | 62.33 | 9.73 | 248 | 229243 | 53274 | 110306534 |
| Death | 62.02 | 9.73 | 1893 | 227598 | 696976 | 109662832 |
| Oral candidiasis | 61.76 | 9.73 | 219 | 229272 | 44541 | 110315267 |
| Bronchitis | 61.26 | 9.73 | 545 | 228946 | 156487 | 110203321 |
| Blood uric acid increased | 61.21 | 9.73 | 137 | 229354 | 21392 | 110338416 |
| Hip arthroplasty | 60.72 | 9.73 | 20 | 229471 | 55793 | 110304015 |
| Fluid retention | 60.16 | 9.73 | 368 | 229123 | 93939 | 110265869 |
| Antacid therapy | 59.65 | 9.73 | 65 | 229426 | 5419 | 110354389 |
| Suicidal ideation | 58.58 | 9.73 | 65 | 229426 | 93872 | 110265936 |
| Incision site pain | 58.48 | 9.73 | 50 | 229441 | 3085 | 110356723 |
| Thrombosis | 58.32 | 9.73 | 406 | 229085 | 108256 | 110251552 |
| Weight increased | 57.35 | 9.73 | 575 | 228916 | 419069 | 109940739 |
| Blood alkaline phosphatase increased | 57.33 | 9.73 | 295 | 229196 | 70640 | 110289168 |
| Cardiomegaly | 57.19 | 9.73 | 161 | 229330 | 28969 | 110330839 |
| Lung consolidation | 56.79 | 9.73 | 88 | 229403 | 10388 | 110349420 |
| Gastrointestinal disorder | 55.80 | 9.73 | 285 | 229206 | 241667 | 110118141 |
| Knee arthroplasty | 55.37 | 9.73 | 33 | 229458 | 64915 | 110294893 |
| Electrolyte imbalance | 55.30 | 9.73 | 186 | 229305 | 36842 | 110322966 |
| Bradycardia | 55.24 | 9.73 | 529 | 228962 | 154988 | 110204820 |
| Lung disorder | 55.22 | 9.73 | 190 | 229301 | 179857 | 110179951 |
| Aortic stenosis | 55.09 | 9.73 | 98 | 229393 | 12961 | 110346847 |
| Sleep disorder | 54.79 | 9.73 | 219 | 229272 | 198425 | 110161383 |
| Encephalopathy | 54.06 | 9.73 | 320 | 229171 | 80735 | 110279073 |
| Intentional self-injury | 53.84 | 9.73 | 7 | 229484 | 37422 | 110322386 |
| Ventricular tachycardia | 53.70 | 9.73 | 226 | 229265 | 49783 | 110310025 |
| Red blood cell sedimentation rate increased | 53.59 | 9.73 | 50 | 229441 | 78252 | 110281556 |
| Onychomycosis | 53.55 | 9.73 | 8 | 229483 | 38523 | 110321285 |
| Bone erosion | 53.36 | 9.73 | 15 | 229476 | 46356 | 110313452 |
| Finger deformity | 53.31 | 9.73 | 4 | 229487 | 33088 | 110326720 |
| Adverse drug reaction | 52.68 | 9.73 | 86 | 229405 | 105473 | 110254335 |
| Hypercholesterolaemia | 52.23 | 9.73 | 67 | 229424 | 90770 | 110269038 |
| Taste disorder | 51.94 | 9.73 | 36 | 229455 | 65351 | 110294457 |
| Metabolic alkalosis | 51.81 | 9.73 | 61 | 229430 | 5534 | 110354274 |
| Foot deformity | 51.64 | 9.73 | 18 | 229473 | 48462 | 110311346 |
| Therapeutic response decreased | 50.65 | 9.73 | 76 | 229415 | 96423 | 110263385 |
| Diabetes insipidus | 50.16 | 9.73 | 65 | 229426 | 6505 | 110353303 |
| End stage renal disease | 49.55 | 9.73 | 126 | 229365 | 21347 | 110338461 |
| Hypoaesthesia | 49.21 | 9.73 | 416 | 229075 | 313807 | 110046001 |
| Injection site swelling | 49.11 | 9.73 | 34 | 229457 | 61756 | 110298052 |
| Coagulopathy | 48.79 | 9.73 | 191 | 229300 | 40720 | 110319088 |
| Immune effector cell-associated neurotoxicity syndrome | 47.68 | 9.73 | 99 | 229392 | 14683 | 110345125 |
| Loss of personal independence in daily activities | 47.58 | 9.73 | 156 | 229335 | 149864 | 110209944 |
| Hypocalcaemia | 47.48 | 9.73 | 264 | 229227 | 65102 | 110294706 |
| Exostosis | 47.37 | 9.73 | 18 | 229473 | 45938 | 110313870 |
| Joint stiffness | 47.13 | 9.73 | 42 | 229449 | 67201 | 110292607 |
| Urinary tract infection | 46.96 | 9.73 | 944 | 228547 | 325338 | 110034470 |
| Insomnia | 46.83 | 9.73 | 500 | 228991 | 360090 | 109999718 |
| Atelectasis | 46.74 | 9.73 | 175 | 229316 | 36537 | 110323271 |
| Blood cholesterol increased | 46.48 | 9.73 | 211 | 229280 | 184574 | 110175234 |
| Spinal muscular atrophy | 46.36 | 9.73 | 21 | 229470 | 406 | 110359402 |
| Headache | 46.17 | 9.73 | 1437 | 228054 | 880940 | 109478868 |
| Diarrhoea | 46.10 | 9.73 | 2844 | 226647 | 1136661 | 109223147 |
| Pulmonary embolism | 46.01 | 9.73 | 662 | 228829 | 213812 | 110145996 |
| Contusion | 45.65 | 9.73 | 290 | 229201 | 233071 | 110126737 |
| Electrocardiogram abnormal | 45.50 | 9.73 | 112 | 229379 | 18597 | 110341211 |
| Sciatica | 45.44 | 9.73 | 76 | 229415 | 92323 | 110267485 |
| Pulse absent | 45.41 | 9.73 | 83 | 229408 | 11209 | 110348599 |
| Liver injury | 45.26 | 9.73 | 160 | 229331 | 150253 | 110209555 |
| Septic shock | 45.15 | 9.73 | 513 | 228978 | 157015 | 110202793 |
| Thrombocytopenia | 44.89 | 9.73 | 993 | 228498 | 347892 | 110011916 |
| Lymphocyte count decreased | 44.83 | 9.73 | 236 | 229255 | 57007 | 110302801 |
| PO2 increased | 44.57 | 9.73 | 32 | 229459 | 1527 | 110358281 |
| Iron deficiency | 44.29 | 9.73 | 110 | 229381 | 18366 | 110341442 |
| Asthenia | 44.10 | 9.73 | 1798 | 227693 | 687201 | 109672607 |
| Generalised oedema | 43.89 | 9.73 | 152 | 229339 | 30552 | 110329256 |
| Transfusion | 43.52 | 9.73 | 134 | 229357 | 25338 | 110334470 |
| Blood glucose increased | 43.31 | 9.73 | 443 | 229048 | 132053 | 110227755 |
| Chills | 42.78 | 9.73 | 593 | 228898 | 189987 | 110169821 |
| Back injury | 41.95 | 9.73 | 23 | 229468 | 47376 | 110312432 |
| Coma | 41.88 | 9.73 | 401 | 229090 | 117468 | 110242340 |
| Syncope | 41.81 | 9.73 | 621 | 228870 | 201915 | 110157893 |
| Rales | 41.21 | 9.73 | 129 | 229362 | 24610 | 110335198 |
| Vomiting | 41.19 | 9.73 | 2296 | 227195 | 908379 | 109451429 |
| Therapy non-responder | 41.15 | 9.73 | 177 | 229314 | 157130 | 110202678 |
| Hypoalbuminaemia | 41.04 | 9.73 | 143 | 229348 | 28831 | 110330977 |
| Injection site bruising | 41.02 | 9.73 | 28 | 229463 | 51235 | 110308573 |
| Multimorbidity | 40.73 | 9.73 | 30 | 229461 | 1490 | 110358318 |
| Blood magnesium decreased | 40.71 | 9.73 | 112 | 229379 | 19884 | 110339924 |
| Tachycardia | 40.38 | 9.73 | 678 | 228813 | 225967 | 110133841 |
| Dementia | 40.34 | 9.73 | 151 | 229340 | 31522 | 110328286 |
| Blood potassium increased | 40.28 | 9.73 | 156 | 229335 | 33093 | 110326715 |
| Asthma | 40.25 | 9.73 | 329 | 229162 | 249962 | 110109846 |
| Blood cholesterol decreased | 40.16 | 9.73 | 38 | 229453 | 2678 | 110357130 |
| Sopor | 39.92 | 9.73 | 13 | 229478 | 36533 | 110323275 |
| Therapeutic product effect incomplete | 39.84 | 9.73 | 286 | 229205 | 223519 | 110136289 |
| Stress | 39.74 | 9.73 | 363 | 229128 | 104985 | 110254823 |
| Administration site extravasation | 39.44 | 9.73 | 31 | 229460 | 1698 | 110358110 |
| Nausea | 39.42 | 9.73 | 3024 | 226467 | 1232666 | 109127142 |
| Inappropriate schedule of product administration | 39.35 | 9.73 | 254 | 229237 | 203383 | 110156425 |
| Renal ischaemia | 39.21 | 9.73 | 35 | 229456 | 2288 | 110357520 |
| Abdominal pain upper | 39.16 | 9.73 | 500 | 228991 | 348611 | 110011197 |
| Hepatic function abnormal | 39.08 | 9.73 | 318 | 229173 | 88977 | 110270831 |
| Malnutrition | 38.95 | 9.73 | 135 | 229356 | 27144 | 110332664 |
| Blood pressure decreased | 38.67 | 9.73 | 387 | 229104 | 114704 | 110245104 |
| Soft tissue mass | 38.27 | 9.73 | 29 | 229462 | 1504 | 110358304 |
| Adverse event | 38.18 | 9.73 | 108 | 229383 | 108701 | 110251107 |
| Exposure during pregnancy | 38.15 | 9.73 | 198 | 229293 | 167226 | 110192582 |
| Peripheral circulatory failure | 38.05 | 9.73 | 31 | 229460 | 1788 | 110358020 |
| Hypovolaemia | 37.95 | 9.73 | 115 | 229376 | 21559 | 110338249 |
| Ileus | 37.90 | 9.73 | 145 | 229346 | 30584 | 110329224 |
| Therapy partial responder | 37.40 | 9.73 | 15 | 229476 | 37046 | 110322762 |
| Granulocytopenia | 37.37 | 9.73 | 82 | 229409 | 12633 | 110347175 |
| Blood pressure fluctuation | 37.30 | 9.73 | 61 | 229430 | 74763 | 110285045 |
| Lupus-like syndrome | 37.27 | 9.73 | 19 | 229472 | 40773 | 110319035 |
| Injection site erythema | 37.24 | 9.73 | 88 | 229403 | 94088 | 110265720 |
| Deep vein thrombosis | 37.17 | 9.73 | 449 | 229042 | 139438 | 110220370 |
| Failure to thrive | 37.05 | 9.73 | 85 | 229406 | 13489 | 110346319 |
| Neuroglycopenia | 36.59 | 9.73 | 25 | 229466 | 1101 | 110358707 |
| Pyrexia | 36.28 | 9.73 | 2242 | 227249 | 896023 | 109463785 |
| Anticoagulant therapy | 36.27 | 9.73 | 50 | 229441 | 5311 | 110354497 |
| Vascular device infection | 36.15 | 9.73 | 95 | 229396 | 16417 | 110343391 |
| PCO2 increased | 35.80 | 9.73 | 31 | 229460 | 1946 | 110357862 |
| Hyperaldosteronism | 35.14 | 9.73 | 20 | 229471 | 635 | 110359173 |
| Clostridium difficile colitis | 34.63 | 9.73 | 181 | 229310 | 43597 | 110316211 |
| Prescribed underdose | 34.52 | 9.73 | 51 | 229440 | 65123 | 110294685 |
| Liver disorder | 34.25 | 9.73 | 165 | 229326 | 142078 | 110217730 |
| Cardiac failure acute | 34.24 | 9.73 | 119 | 229372 | 23959 | 110335849 |
| Hepatitis | 34.15 | 9.73 | 86 | 229405 | 89968 | 110269840 |
| Pancytopenia | 34.09 | 9.73 | 618 | 228873 | 208995 | 110150813 |
| Confusional state | 33.56 | 9.73 | 729 | 228762 | 467951 | 109891857 |
| Full blood count decreased | 32.87 | 9.73 | 143 | 229348 | 31956 | 110327852 |
| Laryngitis | 32.83 | 9.73 | 24 | 229467 | 42387 | 110317421 |
| Respiratory distress | 32.74 | 9.73 | 250 | 229241 | 68624 | 110291184 |
| Lung infiltration | 32.70 | 9.73 | 119 | 229372 | 24509 | 110335299 |
| Lactic acidosis | 32.60 | 9.73 | 315 | 229176 | 92496 | 110267312 |
| Prothrombin time prolonged | 32.52 | 9.73 | 94 | 229397 | 17167 | 110342641 |
| Muscle spasticity | 32.41 | 9.73 | 17 | 229474 | 35898 | 110323910 |
| Oesophageal perforation | 32.05 | 9.73 | 27 | 229464 | 1632 | 110358176 |
| Non-cardiogenic pulmonary oedema | 31.73 | 9.73 | 29 | 229462 | 1955 | 110357853 |
| Oxygen saturation abnormal | 31.64 | 9.73 | 48 | 229443 | 5563 | 110354245 |
| Product quality issue | 31.56 | 9.73 | 71 | 229420 | 77228 | 110282580 |
| Cellulitis | 31.55 | 9.73 | 400 | 229091 | 125616 | 110234192 |
| Drug tolerance decreased | 31.52 | 9.73 | 9 | 229482 | 27531 | 110332277 |
| Adverse reaction | 31.50 | 9.73 | 11 | 229480 | 29583 | 110330225 |
| Hepatic cytolysis | 31.50 | 9.73 | 209 | 229282 | 54844 | 110304964 |
| Pneumonia staphylococcal | 31.40 | 9.73 | 50 | 229441 | 6041 | 110353767 |
| Congestive hepatopathy | 31.36 | 9.73 | 46 | 229445 | 5174 | 110354634 |
| Bacteraemia | 31.32 | 9.73 | 172 | 229319 | 42218 | 110317590 |
| Dyspnoea exertional | 31.23 | 9.73 | 342 | 229149 | 103718 | 110256090 |
| Rheumatoid nodule | 31.20 | 9.73 | 3 | 229488 | 20293 | 110339515 |
| Blood potassium abnormal | 31.17 | 9.73 | 40 | 229451 | 3965 | 110355843 |
| Rectal haemorrhage | 30.70 | 9.73 | 382 | 229109 | 119451 | 110240357 |
| Diaphragmatic spasm | 30.57 | 9.73 | 11 | 229480 | 113 | 110359695 |
| Wrong patient | 30.21 | 9.73 | 25 | 229466 | 1474 | 110358334 |
| Cor pulmonale | 29.99 | 9.73 | 30 | 229461 | 2264 | 110357544 |
| Alanine aminotransferase increased | 29.94 | 9.73 | 542 | 228949 | 183231 | 110176577 |
| Memory impairment | 29.81 | 9.73 | 263 | 229228 | 196681 | 110163127 |
| Hyperpyrexia | 29.57 | 9.73 | 57 | 229434 | 8012 | 110351796 |
| Drug reaction with eosinophilia and systemic symptoms | 29.16 | 9.73 | 81 | 229410 | 82014 | 110277794 |
| Hypophagia | 29.04 | 9.73 | 198 | 229293 | 52428 | 110307380 |
| Blood albumin decreased | 28.94 | 9.73 | 124 | 229367 | 27528 | 110332280 |
| Arrhythmia | 28.43 | 9.73 | 244 | 229247 | 69331 | 110290477 |
| Haematocrit decreased | 28.15 | 9.73 | 234 | 229257 | 65883 | 110293925 |
| Neck pain | 27.83 | 9.73 | 146 | 229345 | 122984 | 110236824 |
| Disability | 27.73 | 9.73 | 14 | 229477 | 30209 | 110329599 |
| Bacteroides infection | 27.32 | 9.73 | 32 | 229459 | 2887 | 110356921 |
| Neuralgia | 27.11 | 9.73 | 183 | 229308 | 48295 | 110311513 |
| Osmotic demyelination syndrome | 27.01 | 9.73 | 27 | 229464 | 2036 | 110357772 |
| Blood creatine increased | 26.99 | 9.73 | 68 | 229423 | 11453 | 110348355 |
| Blood pressure diastolic abnormal | 26.79 | 9.73 | 10 | 229481 | 25805 | 110334003 |
| Gastric polyps | 26.65 | 9.73 | 44 | 229447 | 5479 | 110354329 |
| Peritonitis bacterial | 26.62 | 9.73 | 64 | 229427 | 10469 | 110349339 |
| Calcium deficiency | 26.55 | 9.73 | 21 | 229470 | 1161 | 110358647 |
| Left ventricular failure | 26.45 | 9.73 | 67 | 229424 | 11322 | 110348486 |
| Congenital hiatus hernia | 26.44 | 9.73 | 47 | 229444 | 6212 | 110353596 |
| Electrocardiogram T wave peaked | 26.39 | 9.73 | 21 | 229470 | 1171 | 110358637 |
| Atrioventricular block first degree | 26.35 | 9.73 | 77 | 229414 | 14148 | 110345660 |
| Tumour lysis syndrome | 26.22 | 9.73 | 130 | 229361 | 30671 | 110329137 |
| Ear infection | 26.12 | 9.73 | 57 | 229434 | 62675 | 110297133 |
| Renal tubular acidosis | 26.11 | 9.73 | 40 | 229451 | 4675 | 110355133 |
| Sedation | 26.07 | 9.73 | 67 | 229424 | 69616 | 110290192 |
| Small intestinal obstruction | 26.05 | 9.73 | 134 | 229357 | 32079 | 110327729 |
| Blood chloride decreased | 25.91 | 9.73 | 58 | 229433 | 9057 | 110350751 |
| Haematotoxicity | 25.83 | 9.73 | 6 | 229485 | 21076 | 110338732 |
| Anxiety | 25.78 | 9.73 | 533 | 228958 | 344545 | 110015263 |
| Motor neurone disease | 25.75 | 9.73 | 17 | 229474 | 707 | 110359101 |
| Oxygen consumption increased | 25.72 | 9.73 | 44 | 229447 | 5641 | 110354167 |
| Stoma closure | 25.71 | 9.73 | 14 | 229477 | 407 | 110359401 |
| Joint dislocation | 25.63 | 9.73 | 20 | 229471 | 34170 | 110325638 |
| Walking aid user | 25.55 | 9.73 | 10 | 229481 | 25065 | 110334743 |
| Blood calcium increased | 25.52 | 9.73 | 89 | 229402 | 17951 | 110341857 |
| Suicide attempt | 25.43 | 9.73 | 119 | 229372 | 103275 | 110256533 |
| Multiple allergies | 25.28 | 9.73 | 69 | 229422 | 12194 | 110347614 |
| Hypercapnia | 25.25 | 9.73 | 65 | 229426 | 11094 | 110348714 |
| Brain natriuretic peptide increased | 25.06 | 9.73 | 65 | 229426 | 11144 | 110348664 |
| Troponin increased | 24.89 | 9.73 | 125 | 229366 | 29641 | 110330167 |
| Atrial enlargement | 24.89 | 9.73 | 20 | 229471 | 1131 | 110358677 |
| Acute left ventricular failure | 24.55 | 9.73 | 27 | 229464 | 2274 | 110357534 |
| Aggression | 24.49 | 9.73 | 54 | 229437 | 59156 | 110300652 |
| Compartment syndrome | 24.48 | 9.73 | 44 | 229447 | 5866 | 110353942 |
| Serotonin syndrome | 24.42 | 9.73 | 54 | 229437 | 59099 | 110300709 |
| Urine chloride decreased | 24.38 | 9.73 | 9 | 229482 | 100 | 110359708 |
| Fatigue | 24.31 | 9.73 | 2183 | 227308 | 1213775 | 109146033 |
| Alkalosis | 24.09 | 9.73 | 17 | 229474 | 789 | 110359019 |
| Ventricular extrasystoles | 24.06 | 9.73 | 102 | 229389 | 22539 | 110337269 |
| Haemoptysis | 24.00 | 9.73 | 240 | 229251 | 71114 | 110288694 |
| Therapeutic response shortened | 23.88 | 9.73 | 16 | 229475 | 29567 | 110330241 |
| Electrocardiogram T wave amplitude decreased | 23.81 | 9.73 | 17 | 229474 | 804 | 110359004 |
| Blood bicarbonate decreased | 23.81 | 9.73 | 43 | 229448 | 5754 | 110354054 |
| Supraventricular extrasystoles | 23.66 | 9.73 | 52 | 229439 | 8021 | 110351787 |
| Supraventricular tachycardia | 23.65 | 9.73 | 107 | 229384 | 24315 | 110335493 |
| Blood pH decreased | 23.62 | 9.73 | 38 | 229453 | 4631 | 110355177 |
| Schizophrenia | 23.43 | 9.73 | 8 | 229483 | 21818 | 110337990 |
| Upper gastrointestinal haemorrhage | 23.34 | 9.73 | 181 | 229310 | 49915 | 110309893 |
| Vitamin B1 increased | 23.25 | 9.73 | 10 | 229481 | 170 | 110359638 |
| Lymphoedema | 23.19 | 9.73 | 76 | 229415 | 14853 | 110344955 |
| Depressed mood | 23.11 | 9.73 | 58 | 229433 | 60751 | 110299057 |
| Oesophageal spasm | 23.03 | 9.73 | 33 | 229458 | 3633 | 110356175 |
| Fall | 22.97 | 9.73 | 1499 | 227992 | 601983 | 109757825 |
| Faecal volume decreased | 22.86 | 9.73 | 13 | 229478 | 412 | 110359396 |
| Device related infection | 22.59 | 9.73 | 150 | 229341 | 39369 | 110320439 |
| Tendonitis | 22.59 | 9.73 | 13 | 229478 | 26070 | 110333738 |
| Catheter management | 22.56 | 9.73 | 33 | 229458 | 3702 | 110356106 |
| Blood immunoglobulin M increased | 22.50 | 9.73 | 22 | 229469 | 1615 | 110358193 |
| Glomerular filtration rate | 22.48 | 9.73 | 10 | 229481 | 185 | 110359623 |
| Drug use disorder | 22.43 | 9.73 | 5 | 229486 | 18069 | 110341739 |
| Transient ischaemic attack | 22.39 | 9.73 | 217 | 229274 | 63765 | 110296043 |
| Oesophageal pain | 22.31 | 9.73 | 39 | 229452 | 5086 | 110354722 |
| Chest discomfort | 22.07 | 9.73 | 494 | 228997 | 173354 | 110186454 |
| Miosis | 22.01 | 9.73 | 9 | 229482 | 21974 | 110337834 |
| Pericardial effusion | 22.00 | 9.73 | 198 | 229293 | 57019 | 110302789 |
| Pain in extremity | 21.96 | 9.73 | 808 | 228683 | 486310 | 109873498 |
| Vasoplegia syndrome | 21.90 | 9.73 | 40 | 229451 | 5399 | 110354409 |
| Peripheral swelling | 21.79 | 9.73 | 655 | 228836 | 403379 | 109956429 |
| Condition aggravated | 21.66 | 9.73 | 1276 | 228215 | 733560 | 109626248 |
| Metabolic encephalopathy | 21.58 | 9.73 | 61 | 229430 | 10999 | 110348809 |
| Pruritus | 21.07 | 9.73 | 989 | 228502 | 580571 | 109779237 |
| Nodule | 20.99 | 9.73 | 22 | 229469 | 32609 | 110327199 |
| Electrocardiogram QT prolonged | 20.90 | 9.73 | 330 | 229161 | 108630 | 110251178 |
| Cyanosis | 20.86 | 9.73 | 119 | 229372 | 29622 | 110330186 |
| Cardiomyopathy | 20.85 | 9.73 | 130 | 229361 | 33395 | 110326413 |
| Unresponsive to stimuli | 20.70 | 9.73 | 213 | 229278 | 63577 | 110296231 |
| Product substitution issue | 20.69 | 9.73 | 11 | 229480 | 23050 | 110336758 |
| Wrong technique in product usage process | 20.63 | 9.73 | 102 | 229389 | 87246 | 110272562 |
| Hypoproteinaemia | 20.58 | 9.73 | 41 | 229450 | 5904 | 110353904 |
| Drug ineffective for unapproved indication | 20.51 | 9.73 | 127 | 229364 | 102711 | 110257097 |
| Dry mouth | 20.37 | 9.73 | 292 | 229199 | 199656 | 110160152 |
| Pneumococcal sepsis | 20.29 | 9.73 | 24 | 229467 | 2188 | 110357620 |
| Lip erosion | 20.09 | 9.73 | 22 | 229469 | 1844 | 110357964 |
| Breath sounds abnormal | 20.07 | 9.73 | 105 | 229386 | 25299 | 110334509 |
| Chronic respiratory failure | 20.07 | 9.73 | 32 | 229459 | 3871 | 110355937 |
| Pseudomonal bacteraemia | 20.00 | 9.73 | 34 | 229457 | 4337 | 110355471 |
| Congestive cardiomyopathy | 19.98 | 9.73 | 70 | 229421 | 14149 | 110345659 |
| Haematochezia | 19.98 | 9.73 | 344 | 229147 | 115180 | 110244628 |
| Arrhythmia supraventricular | 19.94 | 9.73 | 25 | 229466 | 2421 | 110357387 |
| Total lung capacity decreased | 19.92 | 9.73 | 45 | 229446 | 7069 | 110352739 |
| Chronic kidney disease | 19.88 | 9.73 | 244 | 229247 | 76047 | 110283761 |
| Hospice care | 19.82 | 9.73 | 64 | 229427 | 12409 | 110347399 |
| Nail dystrophy | 19.74 | 9.73 | 18 | 229473 | 1210 | 110358598 |
| Amnesia | 19.58 | 9.73 | 133 | 229358 | 105275 | 110254533 |
| Right ventricular dysfunction | 19.55 | 9.73 | 29 | 229462 | 3294 | 110356514 |
| Gait disturbance | 19.52 | 9.73 | 434 | 229057 | 277774 | 110082034 |
| Resuscitation | 19.31 | 9.73 | 27 | 229464 | 2906 | 110356902 |
| Blood sodium decreased | 19.29 | 9.73 | 141 | 229350 | 38178 | 110321630 |
| Exercise tolerance decreased | 19.25 | 9.73 | 62 | 229429 | 12005 | 110347803 |
| Anhedonia | 19.19 | 9.73 | 73 | 229418 | 15355 | 110344453 |
| Impaired work ability | 19.12 | 9.73 | 16 | 229475 | 26403 | 110333405 |
| Nightmare | 19.07 | 9.73 | 32 | 229459 | 38831 | 110320977 |
| Transient aphasia | 19.01 | 9.73 | 14 | 229477 | 695 | 110359113 |
| Blood lactic acid decreased | 18.98 | 9.73 | 13 | 229478 | 575 | 110359233 |
| Unevaluable event | 18.86 | 9.73 | 197 | 229294 | 59030 | 110300778 |
| Akathisia | 18.85 | 9.73 | 6 | 229485 | 17107 | 110342701 |
| Epistaxis | 18.66 | 9.73 | 377 | 229114 | 129995 | 110229813 |
| Sedation complication | 18.51 | 9.73 | 9 | 229482 | 19846 | 110339962 |
| Renal phospholipidosis | 18.31 | 9.73 | 11 | 229480 | 387 | 110359421 |
| Burkholderia test positive | 18.28 | 9.73 | 13 | 229478 | 611 | 110359197 |
| Blood loss anaemia | 18.23 | 9.73 | 80 | 229411 | 17945 | 110341863 |
| Cardiac disorder | 18.19 | 9.73 | 240 | 229251 | 76040 | 110283768 |
| Wrong product administered | 18.12 | 9.73 | 57 | 229434 | 10903 | 110348905 |
| Blood pressure systolic abnormal | 18.05 | 9.73 | 15 | 229476 | 24835 | 110334973 |
| Foetal heart rate disorder | 18.00 | 9.73 | 6 | 229485 | 48 | 110359760 |
| Acne | 17.98 | 9.73 | 26 | 229465 | 33494 | 110326314 |
| Rheumatic disorder | 17.86 | 9.73 | 29 | 229462 | 3562 | 110356246 |
| Torsade de pointes | 17.57 | 9.73 | 93 | 229398 | 22507 | 110337301 |
| Vitamin B1 decreased | 17.56 | 9.73 | 15 | 229476 | 924 | 110358884 |
| Somnolence | 17.56 | 9.73 | 770 | 228721 | 296679 | 110063129 |
| Catheter site infection | 17.49 | 9.73 | 46 | 229445 | 7954 | 110351854 |
| Vertigo | 17.47 | 9.73 | 107 | 229384 | 86763 | 110273045 |
| Renal injury | 17.39 | 9.73 | 81 | 229410 | 18632 | 110341176 |
| Catheter site haemorrhage | 17.37 | 9.73 | 38 | 229453 | 5842 | 110353966 |
| Blood pressure systolic increased | 17.33 | 9.73 | 101 | 229390 | 82890 | 110276918 |
| Diabetes mellitus | 17.21 | 9.73 | 296 | 229195 | 99085 | 110260723 |
| Pneumothorax spontaneous | 17.14 | 9.73 | 20 | 229471 | 1797 | 110358011 |
| Skin reaction | 17.12 | 9.73 | 88 | 229403 | 21056 | 110338752 |
| Fluid replacement | 17.10 | 9.73 | 15 | 229476 | 958 | 110358850 |
| Melaena | 17.10 | 9.73 | 218 | 229273 | 68539 | 110291269 |
| Respiratory tract infection bacterial | 17.05 | 9.73 | 23 | 229468 | 2393 | 110357415 |
| Cardiac dysfunction | 17.02 | 9.73 | 39 | 229452 | 6184 | 110353624 |
| Angioedema | 16.98 | 9.73 | 127 | 229364 | 98373 | 110261435 |
| Gastritis erosive | 16.80 | 9.73 | 59 | 229432 | 11941 | 110347867 |
| Blood immunoglobulin A decreased | 16.79 | 9.73 | 22 | 229469 | 2226 | 110357582 |
| Hepatotoxicity | 16.78 | 9.73 | 71 | 229420 | 63329 | 110296479 |
| Superinfection | 16.75 | 9.73 | 37 | 229454 | 5726 | 110354082 |
| Familial periodic paralysis | 16.72 | 9.73 | 10 | 229481 | 349 | 110359459 |
| Blood fibrinogen decreased | 16.69 | 9.73 | 24 | 229467 | 2651 | 110357157 |
| Middle insomnia | 16.67 | 9.73 | 11 | 229480 | 20491 | 110339317 |
| Leukocytosis | 16.65 | 9.73 | 178 | 229313 | 53650 | 110306158 |
| Hyperuricaemia | 16.65 | 9.73 | 67 | 229424 | 14464 | 110345344 |
| Sleep disorder due to a general medical condition | 16.65 | 9.73 | 54 | 229437 | 52058 | 110307750 |
| Basal cell carcinoma | 16.57 | 9.73 | 44 | 229447 | 45226 | 110314582 |
| Leukoplakia oral | 16.54 | 9.73 | 11 | 229480 | 463 | 110359345 |
| Stupor | 16.54 | 9.73 | 46 | 229445 | 8219 | 110351589 |
| Posterior reversible encephalopathy syndrome | 16.51 | 9.73 | 28 | 229463 | 33833 | 110325975 |
| Troponin T increased | 16.50 | 9.73 | 31 | 229460 | 4275 | 110355533 |
| Disease complication | 16.47 | 9.73 | 37 | 229454 | 5790 | 110354018 |
| Left ventricular dysfunction | 16.47 | 9.73 | 94 | 229397 | 23399 | 110336409 |
| Visual impairment | 16.40 | 9.73 | 189 | 229302 | 134239 | 110225569 |
| Hypochloraemia | 16.36 | 9.73 | 28 | 229463 | 3590 | 110356218 |
| Enterobacter pneumonia | 16.34 | 9.73 | 12 | 229479 | 593 | 110359215 |
| Urine output decreased | 16.29 | 9.73 | 83 | 229408 | 19793 | 110340015 |
| Urine sodium decreased | 16.27 | 9.73 | 9 | 229482 | 270 | 110359538 |
| Benign prostatic hyperplasia | 16.27 | 9.73 | 78 | 229413 | 18156 | 110341652 |
| Panniculitis | 16.23 | 9.73 | 6 | 229485 | 15576 | 110344232 |
| Haematoma | 16.10 | 9.73 | 189 | 229302 | 58287 | 110301521 |
| Catheterisation cardiac | 16.06 | 9.73 | 38 | 229453 | 6153 | 110353655 |
| Oxygen therapy | 16.04 | 9.73 | 30 | 229461 | 4123 | 110355685 |
| Bronchopulmonary aspergillosis allergic | 15.98 | 9.73 | 46 | 229445 | 8380 | 110351428 |
| Red blood cells urine positive | 15.88 | 9.73 | 34 | 229457 | 5151 | 110354657 |
| Extrapyramidal disorder | 15.87 | 9.73 | 22 | 229469 | 28845 | 110330963 |
| Mitral valve incompetence | 15.85 | 9.73 | 121 | 229370 | 33208 | 110326600 |
| Hepatocellular injury | 15.82 | 9.73 | 53 | 229438 | 50589 | 110309219 |
| Type IIa hyperlipidaemia | 15.77 | 9.73 | 11 | 229480 | 501 | 110359307 |
| Electrocardiogram ST segment abnormal | 15.77 | 9.73 | 19 | 229472 | 1766 | 110358042 |
| Multiple-drug resistance | 15.76 | 9.73 | 4 | 229487 | 13231 | 110346577 |
| Mental status changes postoperative | 15.75 | 9.73 | 8 | 229483 | 201 | 110359607 |
| Ear pain | 15.75 | 9.73 | 57 | 229434 | 53169 | 110306639 |
| Hallucination, auditory | 15.66 | 9.73 | 19 | 229472 | 26378 | 110333430 |
| Photosensitivity reaction | 15.63 | 9.73 | 18 | 229473 | 25571 | 110334237 |
| Peri-implantitis | 15.54 | 9.73 | 8 | 229483 | 207 | 110359601 |
| Blood parathyroid hormone decreased | 15.50 | 9.73 | 4 | 229487 | 13085 | 110346723 |
| Cardiac pacemaker evaluation | 15.47 | 9.73 | 7 | 229484 | 135 | 110359673 |
| Acute pulmonary oedema | 15.38 | 9.73 | 73 | 229418 | 16923 | 110342885 |
| Shoshin beriberi | 15.34 | 9.73 | 6 | 229485 | 79 | 110359729 |
| Haemodialysis | 15.23 | 9.73 | 75 | 229416 | 17644 | 110342164 |
| Osteonecrosis of jaw | 15.17 | 9.73 | 50 | 229441 | 47967 | 110311841 |
| Vitamin B1 deficiency | 15.17 | 9.73 | 14 | 229477 | 956 | 110358852 |
| Lymphoid tissue hypoplasia | 15.17 | 9.73 | 18 | 229473 | 1647 | 110358161 |
| Affect lability | 15.15 | 9.73 | 10 | 229481 | 18627 | 110341181 |
| Polyneuropathy | 15.13 | 9.73 | 27 | 229464 | 31985 | 110327823 |
| Epididymitis | 15.08 | 9.73 | 22 | 229469 | 2462 | 110357346 |
| Refeeding syndrome | 15.03 | 9.73 | 8 | 229483 | 222 | 110359586 |
| Body temperature decreased | 15.01 | 9.73 | 34 | 229457 | 36901 | 110322907 |
| Drug resistance | 15 | 9.73 | 63 | 229428 | 56311 | 110303497 |
| Thymus hypoplasia | 14.97 | 9.73 | 18 | 229473 | 1669 | 110358139 |
| Ischaemic cerebral infarction | 14.94 | 9.73 | 24 | 229467 | 2921 | 110356887 |
| Cardioactive drug level increased | 14.94 | 9.73 | 28 | 229463 | 3854 | 110355954 |
| Heparin-induced thrombocytopenia test | 14.93 | 9.73 | 8 | 229483 | 225 | 110359583 |
| Blood immunoglobulin M abnormal | 14.93 | 9.73 | 7 | 229484 | 147 | 110359661 |
| Pantoea agglomerans infection | 14.84 | 9.73 | 7 | 229484 | 149 | 110359659 |
| Haemorrhage | 14.77 | 9.73 | 307 | 229184 | 106385 | 110253423 |
| Drug tolerance | 14.75 | 9.73 | 8 | 229483 | 16577 | 110343231 |
| International normalised ratio decreased | 14.70 | 9.73 | 44 | 229447 | 8192 | 110351616 |
| Catheter site extravasation | 14.68 | 9.73 | 11 | 229480 | 561 | 110359247 |
| Oesophagitis | 14.65 | 9.73 | 106 | 229385 | 28609 | 110331199 |
| Lymphadenectomy | 14.65 | 9.73 | 17 | 229474 | 1519 | 110358289 |
| Circulatory collapse | 14.64 | 9.73 | 145 | 229346 | 42848 | 110316960 |
| Sputum increased | 14.59 | 9.73 | 35 | 229456 | 5716 | 110354092 |
| Methaemoglobinaemia | 14.53 | 9.73 | 47 | 229444 | 9121 | 110350687 |
| COVID-19 pneumonia | 14.52 | 9.73 | 129 | 229362 | 37014 | 110322794 |
| Ischaemic cardiomyopathy | 14.49 | 9.73 | 43 | 229448 | 7968 | 110351840 |
| Blood sodium abnormal | 14.49 | 9.73 | 16 | 229475 | 1354 | 110358454 |
| Myocardial ischaemia | 14.49 | 9.73 | 100 | 229391 | 26584 | 110333224 |
| Emphysema | 14.48 | 9.73 | 80 | 229411 | 19676 | 110340132 |
| Neonatal gastrointestinal disorder | 14.48 | 9.73 | 5 | 229486 | 45 | 110359763 |
| Polyarthritis | 14.33 | 9.73 | 11 | 229480 | 18952 | 110340856 |
| Poisoning | 14.25 | 9.73 | 24 | 229467 | 29081 | 110330727 |
| Hypertension | 14.25 | 9.73 | 890 | 228601 | 509194 | 109850614 |
| Muscle spasms | 14.24 | 9.73 | 454 | 229037 | 277703 | 110082105 |
| Acute respiratory distress syndrome | 14.23 | 9.73 | 171 | 229320 | 53027 | 110306781 |
| Temperature intolerance | 14.17 | 9.73 | 62 | 229429 | 13888 | 110345920 |
| Metabolic acidosis | 14.13 | 9.73 | 288 | 229203 | 99456 | 110260352 |
| Blood immunoglobulin G increased | 14.08 | 9.73 | 27 | 229464 | 3781 | 110356027 |
| Feeling hot | 14.07 | 9.73 | 121 | 229370 | 90985 | 110268823 |
| Cardiac output increased | 14.03 | 9.73 | 11 | 229480 | 600 | 110359208 |
| Cardiovascular disorder | 14.00 | 9.73 | 88 | 229403 | 22672 | 110337136 |
| Mood swings | 13.99 | 9.73 | 16 | 229475 | 22796 | 110337012 |
| Transplant failure | 13.98 | 9.73 | 34 | 229457 | 5601 | 110354207 |
| Accidental exposure to product | 13.86 | 9.73 | 55 | 229436 | 49953 | 110309855 |
| Forced expiratory volume decreased | 13.85 | 9.73 | 5 | 229486 | 13171 | 110346637 |
| Lower respiratory tract infection bacterial | 13.84 | 9.73 | 14 | 229477 | 1071 | 110358737 |
| Polyuria | 13.80 | 9.73 | 73 | 229418 | 17665 | 110342143 |
| Injection site rash | 13.74 | 9.73 | 17 | 229474 | 23402 | 110336406 |
| Blood phosphorus decreased | 13.73 | 9.73 | 41 | 229450 | 7624 | 110352184 |
| Movement disorder | 13.62 | 9.73 | 35 | 229456 | 36369 | 110323439 |
| Chronic kidney disease-mineral and bone disorder | 13.61 | 9.73 | 11 | 229480 | 627 | 110359181 |
| Mitral valve disease | 13.55 | 9.73 | 25 | 229466 | 3400 | 110356408 |
| Multiple drug therapy | 13.54 | 9.73 | 42 | 229449 | 7972 | 110351836 |
| Psychotic disorder | 13.51 | 9.73 | 57 | 229434 | 50880 | 110308928 |
| Occult blood positive | 13.50 | 9.73 | 40 | 229451 | 7405 | 110352403 |
| Scrotal oedema | 13.41 | 9.73 | 17 | 229474 | 1664 | 110358144 |
| Increased bronchial secretion | 13.39 | 9.73 | 27 | 229464 | 3921 | 110355887 |
| Neutrophil count increased | 13.37 | 9.73 | 120 | 229371 | 34532 | 110325276 |
| Pneumonia klebsiella | 13.36 | 9.73 | 37 | 229454 | 6595 | 110353213 |
| Injection site warmth | 13.28 | 9.73 | 10 | 229481 | 17395 | 110342413 |
| Personality disorder | 13.28 | 9.73 | 5 | 229486 | 12832 | 110346976 |
| Skin dystrophy | 13.27 | 9.73 | 5 | 229486 | 59 | 110359749 |
| Acute myocardial infarction | 13.26 | 9.73 | 246 | 229245 | 83531 | 110276277 |
| Skin candida | 13.25 | 9.73 | 20 | 229471 | 2308 | 110357500 |
| Electrocardiogram P wave abnormal | 13.24 | 9.73 | 9 | 229482 | 393 | 110359415 |
| Post transplant lymphoproliferative disorder | 13.21 | 9.73 | 8 | 229483 | 15605 | 110344203 |
| Injection site pruritus | 13.20 | 9.73 | 58 | 229433 | 51200 | 110308608 |
| Nutritional condition abnormal | 13.18 | 9.73 | 15 | 229476 | 1312 | 110358496 |
| Hepatic failure | 13.11 | 9.73 | 208 | 229283 | 68531 | 110291277 |
| Tonsillar haemorrhage | 13.10 | 9.73 | 8 | 229483 | 290 | 110359518 |
| Vascular encephalopathy | 13.09 | 9.73 | 12 | 229479 | 812 | 110358996 |
| Pulseless electrical activity | 13.06 | 9.73 | 69 | 229422 | 16688 | 110343120 |
| Intracardiac mass | 13.03 | 9.73 | 8 | 229483 | 293 | 110359515 |
| Cardiovascular insufficiency | 13.01 | 9.73 | 24 | 229467 | 3264 | 110356544 |
| Lower gastrointestinal haemorrhage | 12.98 | 9.73 | 74 | 229417 | 18412 | 110341396 |
| Mucosal erosion | 12.96 | 9.73 | 22 | 229469 | 2802 | 110357006 |
| Product administration error | 12.91 | 9.73 | 126 | 229365 | 37091 | 110322717 |
| Arteriovenous malformation | 12.91 | 9.73 | 18 | 229473 | 1933 | 110357875 |
| Diuretic therapy | 12.90 | 9.73 | 7 | 229484 | 202 | 110359606 |
| Dystonia | 12.89 | 9.73 | 21 | 229470 | 25784 | 110334024 |
| Glomerular filtration rate abnormal | 12.89 | 9.73 | 20 | 229471 | 2363 | 110357445 |
| Epidermolysis | 12.88 | 9.73 | 14 | 229477 | 1164 | 110358644 |
| Right ventricular dilatation | 12.87 | 9.73 | 20 | 229471 | 2367 | 110357441 |
| Depression | 12.84 | 9.73 | 533 | 228958 | 316802 | 110043006 |
| Bilirubin conjugated increased | 12.81 | 9.73 | 35 | 229456 | 6189 | 110353619 |
| Pulmonary arterial pressure increased | 12.79 | 9.73 | 31 | 229460 | 5096 | 110354712 |
| Initial insomnia | 12.79 | 9.73 | 49 | 229442 | 10340 | 110349468 |
| Sinus tachycardia | 12.78 | 9.73 | 145 | 229346 | 44348 | 110315460 |
| Stevens-Johnson syndrome | 12.65 | 9.73 | 151 | 229340 | 46750 | 110313058 |
| Disturbance in attention | 12.65 | 9.73 | 76 | 229415 | 61919 | 110297889 |
| Obstructive airways disorder | 12.64 | 9.73 | 51 | 229440 | 46098 | 110313710 |
| Ulcer | 12.61 | 9.73 | 141 | 229350 | 42975 | 110316833 |
| Oropharyngeal pain | 12.59 | 9.73 | 201 | 229290 | 135075 | 110224733 |
| Coronary artery disease | 12.59 | 9.73 | 214 | 229277 | 71476 | 110288332 |
| Benign soft tissue neoplasm | 12.58 | 9.73 | 6 | 229485 | 131 | 110359677 |
| Product storage error | 12.51 | 9.73 | 16 | 229475 | 21712 | 110338096 |
| Drug eruption | 12.47 | 9.73 | 63 | 229428 | 53596 | 110306212 |
| Alveolar lung disease | 12.47 | 9.73 | 11 | 229480 | 708 | 110359100 |
| Electrocardiogram U wave present | 12.42 | 9.73 | 6 | 229485 | 135 | 110359673 |
| Malaise | 12.39 | 9.73 | 1213 | 228278 | 670606 | 109689202 |
| Retroperitoneal haemorrhage | 12.38 | 9.73 | 34 | 229457 | 6031 | 110353777 |
| Cerebral haematoma | 12.33 | 9.73 | 46 | 229445 | 9586 | 110350222 |
| Mania | 12.31 | 9.73 | 15 | 229476 | 20781 | 110339027 |
| Blood immunoglobulin G abnormal | 12.26 | 9.73 | 6 | 229485 | 139 | 110359669 |
| Manufacturing laboratory analytical testing issue | 12.26 | 9.73 | 3 | 229488 | 6 | 110359802 |
| Hyperdynamic left ventricle | 12.20 | 9.73 | 10 | 229481 | 582 | 110359226 |
| Drug chemical incompatibility | 12.18 | 9.73 | 6 | 229485 | 141 | 110359667 |
| N-terminal prohormone brain natriuretic peptide increased | 12.18 | 9.73 | 34 | 229457 | 6087 | 110353721 |
| Injection site haemorrhage | 12.17 | 9.73 | 32 | 229459 | 32996 | 110326812 |
| Decubitus ulcer | 12.16 | 9.73 | 72 | 229419 | 18164 | 110341644 |
| Hydronephrosis | 12.15 | 9.73 | 79 | 229412 | 20586 | 110339222 |
| Prostate cancer | 12.03 | 9.73 | 39 | 229452 | 37602 | 110322206 |
| Thyroid disorder | 11.97 | 9.73 | 68 | 229423 | 16901 | 110342907 |
| Aspiration | 11.91 | 9.73 | 106 | 229385 | 30427 | 110329381 |
| Adenocarcinoma | 11.90 | 9.73 | 27 | 229464 | 4253 | 110355555 |
| Incorrect route of product administration | 11.90 | 9.73 | 193 | 229298 | 63868 | 110295940 |
| Ankylosing spondylitis | 11.87 | 9.73 | 9 | 229482 | 15603 | 110344205 |
| Polyglandular disorder | 11.84 | 9.73 | 7 | 229484 | 239 | 110359569 |
| Chronic left ventricular failure | 11.79 | 9.73 | 14 | 229477 | 1282 | 110358526 |
| Injection site urticaria | 11.77 | 9.73 | 11 | 229480 | 17204 | 110342604 |
| Influenza like illness | 11.70 | 9.73 | 122 | 229369 | 88290 | 110271518 |
| Staphylococcal sepsis | 11.69 | 9.73 | 69 | 229422 | 17385 | 110342423 |
| Mastoid effusion | 11.68 | 9.73 | 4 | 229487 | 35 | 110359773 |
| Inability to afford medication | 11.66 | 9.73 | 26 | 229465 | 4050 | 110355758 |
| Haematoma muscle | 11.60 | 9.73 | 26 | 229465 | 4064 | 110355744 |
| Pleuritic pain | 11.59 | 9.73 | 65 | 229426 | 16075 | 110343733 |
| Rhinitis | 11.59 | 9.73 | 18 | 229473 | 22527 | 110337281 |
| Oral papilloma | 11.57 | 9.73 | 5 | 229486 | 86 | 110359722 |
| Central nervous system injury | 11.52 | 9.73 | 6 | 229485 | 159 | 110359649 |
| Neonatal respiratory depression | 11.52 | 9.73 | 5 | 229486 | 87 | 110359721 |
| Lactobacillus test positive | 11.49 | 9.73 | 4 | 229487 | 37 | 110359771 |
| Subdural haematoma | 11.49 | 9.73 | 121 | 229370 | 36333 | 110323475 |
| Pustular psoriasis | 11.47 | 9.73 | 7 | 229484 | 13598 | 110346210 |
| Tardive dyskinesia | 11.43 | 9.73 | 7 | 229484 | 13572 | 110346236 |
| Pseudomonal sepsis | 11.41 | 9.73 | 43 | 229448 | 9003 | 110350805 |
| Abortion incomplete complicated | 11.40 | 9.73 | 3 | 229488 | 9 | 110359799 |
| Paranoia | 11.38 | 9.73 | 18 | 229473 | 22356 | 110337452 |
| Micturition disorder | 11.29 | 9.73 | 28 | 229463 | 4670 | 110355138 |
| Red blood cell count decreased | 11.29 | 9.73 | 196 | 229295 | 65727 | 110294081 |
| Intestinal polyp | 11.25 | 9.73 | 19 | 229472 | 2410 | 110357398 |
| Lung opacity | 11.24 | 9.73 | 51 | 229440 | 11601 | 110348207 |
| Ejection fraction decreased | 11.20 | 9.73 | 132 | 229359 | 40748 | 110319060 |
| Food allergy | 11.17 | 9.73 | 15 | 229476 | 19933 | 110339875 |
| Sensory loss | 11.16 | 9.73 | 17 | 229474 | 21440 | 110338368 |
| Peptic ulcer | 11.13 | 9.73 | 38 | 229453 | 7581 | 110352227 |
| Iatrogenic infection | 11.12 | 9.73 | 5 | 229486 | 95 | 110359713 |
| Cytomegalovirus infection reactivation | 11.09 | 9.73 | 13 | 229478 | 18320 | 110341488 |
| Photophobia | 11.07 | 9.73 | 23 | 229468 | 25748 | 110334060 |
| Splenic injury | 11.07 | 9.73 | 7 | 229484 | 270 | 110359538 |
| Device related sepsis | 11.05 | 9.73 | 38 | 229453 | 7609 | 110352199 |
| Hyponatraemic encephalopathy | 10.99 | 9.73 | 8 | 229483 | 390 | 110359418 |
| Progressive multifocal leukoencephalopathy | 10.96 | 9.73 | 22 | 229469 | 24934 | 110334874 |
| Blood aldosterone abnormal | 10.95 | 9.73 | 4 | 229487 | 43 | 110359765 |
| Renal impairment | 10.93 | 9.73 | 487 | 229004 | 187958 | 110171850 |
| Salivary hypersecretion | 10.92 | 9.73 | 12 | 229479 | 17409 | 110342399 |
| Neutropenia | 10.91 | 9.73 | 911 | 228580 | 373709 | 109986099 |
| Spontaneous haemorrhage | 10.90 | 9.73 | 13 | 229478 | 1195 | 110358613 |
| Vasculitis | 10.89 | 9.73 | 38 | 229453 | 35835 | 110323973 |
| Ageusia | 10.89 | 9.73 | 74 | 229417 | 19571 | 110340237 |
| Potassium wasting nephropathy | 10.88 | 9.73 | 6 | 229485 | 179 | 110359629 |
| Cortical visual impairment | 10.87 | 9.73 | 4 | 229487 | 44 | 110359764 |
| Throat irritation | 10.75 | 9.73 | 66 | 229425 | 53486 | 110306322 |
| Eczema | 10.73 | 9.73 | 97 | 229394 | 72196 | 110287612 |
| Agranulocytosis | 10.71 | 9.73 | 184 | 229307 | 61576 | 110298232 |
| Multiple sclerosis relapse | 10.57 | 9.73 | 61 | 229430 | 50179 | 110309629 |
| Dry eye | 10.56 | 9.73 | 70 | 229421 | 55723 | 110304085 |
| Hernia | 10.54 | 9.73 | 73 | 229418 | 19427 | 110340381 |
| Head injury | 10.53 | 9.73 | 136 | 229355 | 42881 | 110316927 |
| Encapsulating peritoneal sclerosis | 10.50 | 9.73 | 11 | 229480 | 877 | 110358931 |
| Pharyngeal swelling | 10.41 | 9.73 | 6 | 229485 | 12026 | 110347782 |
| Hypotonia | 10.39 | 9.73 | 62 | 229429 | 15683 | 110344125 |
| Pulmonary interstitial emphysema syndrome | 10.38 | 9.73 | 9 | 229482 | 566 | 110359242 |
| Lethargy | 10.38 | 9.73 | 261 | 229230 | 93315 | 110266493 |
| Deficiency anaemia | 10.37 | 9.73 | 5 | 229486 | 112 | 110359696 |
| Exposure to toxic agent | 10.32 | 9.73 | 7 | 229484 | 12851 | 110346957 |
| Carbon dioxide increased | 10.31 | 9.73 | 20 | 229471 | 2824 | 110356984 |
| Urosepsis | 10.23 | 9.73 | 103 | 229388 | 30572 | 110329236 |
| Biliary obstruction | 10.21 | 9.73 | 30 | 229461 | 5528 | 110354280 |
| Endotracheal intubation | 10.20 | 9.73 | 32 | 229459 | 6112 | 110353696 |
| Pain in jaw | 10.19 | 9.73 | 156 | 229335 | 51021 | 110308787 |
| Cardiac failure chronic | 10.17 | 9.73 | 56 | 229435 | 13755 | 110346053 |
| Thyroxine decreased | 10.17 | 9.73 | 11 | 229480 | 909 | 110358899 |
| Cor pulmonale chronic | 10.13 | 9.73 | 8 | 229483 | 441 | 110359367 |
| Staphylococcus test positive | 10.11 | 9.73 | 36 | 229455 | 7334 | 110352474 |
| Cataract operation | 10.10 | 9.73 | 31 | 229460 | 5852 | 110353956 |
| Poisoning deliberate | 10.10 | 9.73 | 25 | 229466 | 26306 | 110333502 |
| Hallucination, visual | 10.09 | 9.73 | 45 | 229446 | 39560 | 110320248 |
| Deposit eye | 10.07 | 9.73 | 4 | 229487 | 55 | 110359753 |
| Cardiomyopathy alcoholic | 10.07 | 9.73 | 4 | 229487 | 55 | 110359753 |
| Unintentional medical device removal | 10.06 | 9.73 | 3 | 229488 | 8920 | 110350888 |
| Extrasystoles | 10.05 | 9.73 | 39 | 229452 | 8279 | 110351529 |
| Fear of injection | 10.04 | 9.73 | 3 | 229488 | 8908 | 110350900 |
| Enterococcus test positive | 10.02 | 9.73 | 20 | 229471 | 2884 | 110356924 |
| Diverticulum intestinal haemorrhagic | 10.02 | 9.73 | 27 | 229464 | 4736 | 110355072 |
| Endocrine disorder | 9.99 | 9.73 | 12 | 229479 | 1112 | 110358696 |
| Staphylococcal infection | 9.92 | 9.73 | 202 | 229289 | 69742 | 110290066 |
| Complication of device insertion | 9.91 | 9.73 | 3 | 229488 | 8835 | 110350973 |
| Adjustment disorder | 9.90 | 9.73 | 5 | 229486 | 10790 | 110349018 |
| Dissociation | 9.90 | 9.73 | 4 | 229487 | 9838 | 110349970 |
| Euphoric mood | 9.89 | 9.73 | 3 | 229488 | 8824 | 110350984 |
| Haemorrhoidal haemorrhage | 9.82 | 9.73 | 38 | 229453 | 8055 | 110351753 |
| Blood glucose decreased | 9.82 | 9.73 | 99 | 229392 | 29389 | 110330419 |
| Hyperbilirubinaemia | 9.76 | 9.73 | 102 | 229389 | 30569 | 110329239 |
| Myalgia | 9.75 | 9.73 | 370 | 229121 | 222011 | 110137797 |
| Sensory integrative dysfunction | 9.74 | 9.73 | 3 | 229488 | 18 | 110359790 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product preparation error | 34.50 | 34.24 | 13 | 342 | 100 | 113498 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B05CX01 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Other irrigating solutions |
| ATC | C05BB56 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Sclerosing agents for local injection |
| ATC | V04CA02 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for diabetes |
| ATC | V06DC01 | VARIOUS GENERAL NUTRIENTS OTHER NUTRIENTS Carbohydrates |
| MeSH PA | D005421 | Flavoring Agents |
| MeSH PA | D005503 | Food Additives |
| MeSH PA | D013549 | Sweetening Agents |
| CHEBI has role | CHEBI:78675 | fundamental metabolite |
Related Drugs by ATC class:
C05BB Sclerosing agents for local injection 4 drugs
V04CA Tests for diabetes 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypoglycemia | indication | 302866003 | DOID:9993 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Dehydration associated with diarrhea | Indication |
| Cattle | Early treatment of scouring | Indication |
| Cattle | Followup treatment following intravenous fluid therapy | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Re-Sorb, Vytrate | Zoetis Inc. | 6 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.87 | acidic |
| pKa2 | 13.08 | acidic |
| pKa3 | 13.91 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019541 | VUID |
| N0000147647 | NUI |
| D00009 | KEGG_DRUG |
| 77938-63-7 | SECONDARY_CAS_RN |
| 50-99-7 | SECONDARY_CAS_RN |
| 1299920 | RXNORM |
| 4017760 | VANDF |
| 4019541 | VANDF |
| C0017725 | UMLSCUI |
| CHEBI:4167 | CHEBI |
| BGC | PDB_CHEM_ID |
| CHEMBL1222250 | ChEMBL_ID |
| D005947 | MESH_DESCRIPTOR_UI |
| DB09341 | DRUGBANK_ID |
| 5793 | PUBCHEM_CID |
| DB01914 | DRUGBANK_ID |
| 11133 | MMSL |
| 4567 | MMSL |
| 4787 | MMSL |
| 71873 | MMSL |
| 71874 | MMSL |
| 9763 | MMSL |
| d00595 | MMSL |
| 000915 | NDDF |
| 002597 | NDDF |
| 111138002 | SNOMEDCT_US |
| 67079006 | SNOMEDCT_US |
| 725859007 | SNOMEDCT_US |
| 768547002 | SNOMEDCT_US |
| 4536 | IUPHAR_LIGAND_ID |
| LX22YL083G | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-1510 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | NDA | 24 sections |
| Isolyte P in Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0264-7730 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 23 sections |
| Dextrose in Lactated Ringers | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0264-7751 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 24 sections |
| Heparin Sodium in Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9567 | INJECTION | 5 g | INTRAVENOUS | NDA | 19 sections |
| Heparin Sodium in Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9577 | INJECTION | 5 g | INTRAVENOUS | NDA | 19 sections |
| Heparin Sodium in Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9587 | INJECTION | 5 g | INTRAVENOUS | NDA | 19 sections |
| Lidocaine Hydrochloride and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9594 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 23 sections |
| Lidocaine Hydrochloride and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9598 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 23 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0017 | INJECTION, SOLUTION | 50 g | INTRAVENOUS | NDA | 25 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0023 | INJECTION, SOLUTION | 100 g | INTRAVENOUS | NDA | 25 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0062 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0066 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0070 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0338-0073 | INJECTION, SOLUTION | 2.50 g | INTRAVENOUS | NDA | 21 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0074 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0338-0077 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0078 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0082 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0338-0085 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0338-0089 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Lactated Ringers and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0338-0125 | INJECTION, SOLUTION | 5 g | INTRAVENOUS | NDA | 26 sections |
| Dextrose and Electrolyte No. 48 | HUMAN PRESCRIPTION DRUG LABEL | 6 | 0338-0143 | INJECTION | 5 g | INTRAVENOUS | NDA | 19 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0170 | INJECTION | 2.50 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0172 | INJECTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0174 | INJECTION | 2.50 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0176 | INJECTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0204 | INJECTION | 2.50 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0208 | INJECTION | 5 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0211 | INJECTION | 2.50 g | INTRAVENOUS | NDA | 21 sections |
| Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0216 | INJECTION | 5 g | INTRAVENOUS | NDA | 21 sections |