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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	597	55-56-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chlorhexidine hydrochloride chlorhexidine chlorohex chlorohexidine chlorhexidine gluconate chlorhexidine acetate	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. Molecular weight: 505.45 Formula: C22H30Cl2N10 CLOGP: 4.81 LIPINSKI: 2 HAC: 10 HDO: 10 TPSA: 167.58 ALOGS: -4.29 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlorhexidine hydrochloride
chlorhexidine
chlorohex
chlorohexidine
chlorhexidine gluconate
chlorhexidine acetate

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Molecular weight: 505.45
Formula: C22H30Cl2N10
CLOGP: 4.81
LIPINSKI: 2
HAC: 10
HDO: 10
TPSA: 167.58
ALOGS: -4.29
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O
30	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)	1 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	0.03 mg/mL	Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	0.973		Moderate	0.78
caco2-efflux	Caco-2 efflux ratio (BA/AB)	14.791		Moderate	0.78
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.362	10^-6 cm/s	Moderate	0.78
dh-clint	Dog hepatocyte intrinsic clearance	8.630	uL/min/10^6 cells	Moderate	0.78
dppb	Dog plasma protein binding (% unbound)	0.150	%	Moderate	0.78
fcs-ppb	Fetal calf serum protein binding (% unbound)	6.670	%	Moderate	0.78
herg	hERG pIC50	5.170	pIC50	Moderate	0.78
hh-clint	Human hepatocyte intrinsic clearance	15.453	uL/min/10^6 cells	Moderate	0.78
hlm-clint	Human liver microsomal intrinsic clearance	8.414	uL/min/mg protein	Moderate	0.78
hppb	Human plasma protein binding (% unbound)	0.450	%	Moderate	0.78
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2	65
kinase-selectivity-class	ACVR2A,ACVR2B,AXL,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,FLT3,GRK2,MAP3K21,MAPK12,MAPK7,PDK4,SIK2,STK33,TEK,TTK	18
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	8.670		Moderate	0.78
mh-clint	Mouse hepatocyte intrinsic clearance	10.023		Moderate	0.78
mppb	Mouse plasma protein binding (% unbound)	0.110		Moderate	0.78
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	38.107		Moderate	0.78
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	1.870	%	Moderate	0.78
rh-clint	Rat hepatocyte intrinsic clearance	9.226	uL/min/10^6 cells	Moderate	0.78
rh-fuinc	Rat hepatocyte fraction unbound in incubation	0.660	%	Moderate	0.78
rppb	Rat plasma protein binding (% unbound)	0.200	%	Moderate	0.78
solubility-dd	Solubility at pH 7.4 in DMSO	292.415	uM	Moderate	0.78

Approvals:

Date	Agency	Company	Orphan
Sept. 17, 1976	FDA	MOLNLYCKE HLTH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Folliculitis	2564.53	26.98	3081	263745	201272	90160349
Muscle injury	2262.68	26.98	2692	264134	173962	90187659
Irritable bowel syndrome	2211.55	26.98	2883	263943	204565	90157056
Impaired healing	2138.85	26.98	3019	263807	231180	90130441
Lower respiratory tract infection	2025.93	26.98	3050	263776	247609	90114012
Sleep disorder due to general medical condition, insomnia type	1877.13	26.98	2098	264728	126596	90235025
Ill-defined disorder	1759.46	26.98	2432	264394	182459	90179162
Blister	1729.76	26.98	2864	263962	252134	90109487
Stomatitis	1691.39	26.98	2955	263871	271743	90089878
Helicobacter infection	1530.11	26.98	2542	264284	224308	90137313
Duodenal ulcer perforation	1496.90	26.98	2483	264343	218805	90142816
Gastrointestinal disorder	1465.11	26.98	2672	264154	254015	90107606
Pericarditis	1115.92	26.98	2458	264368	267693	90093928
Anti-cyclic citrullinated peptide antibody positive	1083.26	26.98	2244	264582	234189	90127432
Sinusitis	1083.26	26.98	2812	264014	340276	90021345
Hand deformity	1079.87	26.98	2566	264260	293796	90067825
Confusional state	969.44	26.98	2912	263914	383293	89978328
Glossodynia	963.23	26.98	2586	264240	319193	90042428
Peripheral swelling	951.77	26.98	3023	263803	410083	89951538
Wound	906.75	26.98	2435	264391	300545	90061076
Joint swelling	875.11	26.98	3355	263471	499945	89861676
Weight increased	873.53	26.98	2959	263867	414968	89946653
Synovitis	867.71	26.98	2529	264297	327223	90034398
Infection	852.25	26.98	2670	264156	359424	90002197
Swelling	834.73	26.98	2920	263906	416138	89945483
Pemphigus	808.79	26.98	2453	264373	324411	90037210
Hypersensitivity	806.62	26.98	3051	263775	451626	89909995
Hepatic enzyme increased	804.22	26.98	2611	264215	358125	90003496
Contusion	802.29	26.98	2069	264757	249147	90112474
Nasopharyngitis	784.29	26.98	2806	264020	404298	89957323
Discomfort	777.87	26.98	2162	264664	272173	90089448
Cough	769.02	26.98	92	266734	368870	89992751
Systemic lupus erythematosus	744.93	26.98	2550	264276	359346	90002275
Therapeutic product effect decreased	723.25	26.98	2122	264704	275449	90086172
Injury	695.58	26.98	1688	265138	195661	90165960
Toxicity to various agents	686.56	26.98	40	266786	287806	90073815
Night sweats	686.40	26.98	1303	265523	127463	90234158
Drug interaction	682.77	26.98	31	266795	276422	90085199
Product dose omission issue	670.69	26.98	49	266777	291638	90069983
Anaemia	670.02	26.98	116	266710	352686	90008935
Lip dry	665.60	26.98	1121	265705	99834	90261787
Nausea	656.40	26.98	1438	265388	1108878	89252743
Arthropathy	632.71	26.98	2438	264388	363804	89997817
Acute kidney injury	622.45	26.98	99	266727	320288	90041333
Joint range of motion decreased	622.25	26.98	1289	265537	134354	90227267
Facet joint syndrome	615.02	26.98	1067	265759	97322	90264299
Sleep disorder	599.19	26.98	1599	265227	196431	90165190
Rheumatic fever	591.84	26.98	1358	265468	151763	90209858
Fall	582.28	26.98	349	266477	481461	89880160
Hypotension	577.72	26.98	126	266700	325271	90036350
Death	572.65	26.98	316	266510	456235	89905386
Infusion related reaction	544.13	26.98	2548	264278	414232	89947389
Rheumatoid arthritis	532.62	26.98	2296	264530	360318	90001303
Urinary tract infection	525.29	26.98	127	266699	305505	90056116
Type 2 diabetes mellitus	522.48	26.98	1547	265279	201697	90159924
Deep vein thrombosis postoperative	514.90	26.98	822	266004	69987	90291634
C-reactive protein abnormal	507.73	26.98	1144	265682	126285	90235336
Pruritus	500.28	26.98	3009	263817	538516	89823105
Constipation	494.78	26.98	110	266716	280285	90081336
Fibromyalgia	465.11	26.98	1500	265326	204769	90156852
Peripheral venous disease	461.65	26.98	861	265965	83060	90278561
Autoimmune disorder	454.58	26.98	813	266013	75931	90285690
Dehydration	443.03	26.98	34	266792	194413	90167208
Urticaria	436.02	26.98	1950	264876	310784	90050837
Somnolence	425.92	26.98	56	266770	209028	90152593
Road traffic accident	422.86	26.98	961	265865	106665	90254956
Psoriatic arthropathy	418.53	26.98	1550	265276	226785	90134836
Blood pressure increased	416.02	26.98	47	266779	197170	90164451
Swollen joint count increased	414.96	26.98	973	265853	110233	90251388
Injection site pain	411.39	26.98	25	266801	173674	90187947
Gait inability	407.32	26.98	1147	265679	145309	90216312
Grip strength decreased	404.87	26.98	863	265963	91713	90269908
Completed suicide	404.73	26.98	4	266822	145054	90216567
Neutropenia	389.19	26.98	92	266734	224812	90136809
Feeling abnormal	387.38	26.98	27	266799	167208	90194413
COVID-19	386.11	26.98	29	266797	168814	90192807
Adjustment disorder with depressed mood	384.30	26.98	638	266188	56115	90305506
Myalgia	381.56	26.98	37	266789	175088	90186533
Blood cholesterol increased	379.45	26.98	1410	265416	206602	90155019
Wound infection	375.42	26.98	911	265915	105491	90256130
Bursitis	372.88	26.98	1038	265788	130616	90231005
Lower limb fracture	372.33	26.98	793	266033	84220	90277401
Liver injury	369.65	26.98	1224	265602	169343	90192278
Ear pain	354.21	26.98	621	266205	57081	90304540
Abdominal discomfort	353.45	26.98	2510	264316	474818	89886803
Erythema	348.26	26.98	120	266706	229126	90132495
Dislocation of vertebra	347.02	26.98	605	266221	55363	90306258
Rheumatoid factor positive	342.29	26.98	1198	265628	170452	90191169
Hypercholesterolaemia	337.07	26.98	846	265980	100046	90261575
Haemoglobin decreased	335.59	26.98	41	266785	161915	90199706
Hyperhidrosis	330.84	26.98	17	266809	136288	90225333
Contraindicated product administered	327.54	26.98	1829	264997	318310	90043311
Breast cancer stage III	323.88	26.98	747	266079	83700	90277921
Alopecia	319.92	26.98	2521	264305	492550	89869071
Influenza	318.18	26.98	24	266802	139240	90222381
Obesity	315.81	26.98	849	265977	104658	90256963
Tremor	314.38	26.98	40	266786	153133	90208488
Respiratory disorder	312.43	26.98	629	266197	64187	90297434
Sciatica	310.72	26.98	823	266003	100559	90261062
X-ray abnormal	306.66	26.98	510	266316	44914	90316707
Dry mouth	301.51	26.98	1206	265620	182853	90178768
Seizure	301.12	26.98	45	266781	152584	90209037
Insomnia	297.69	26.98	1838	264988	331636	90029985
Syncope	297.12	26.98	25	266801	132638	90228983
Muscle spasticity	294.56	26.98	437	266389	34885	90326736
Hyponatraemia	294.10	26.98	27	266799	133511	90228110
Renal failure	292.55	26.98	25	266801	130982	90230639
White blood cell count decreased	289.77	26.98	68	266758	167041	90194580
Chills	287.17	26.98	28	266798	131953	90229668
Drug ineffective	283.98	26.98	2661	264165	1381637	88979984
Myocardial infarction	278.60	26.98	7	266819	105965	90255656
Atrial fibrillation	273.94	26.98	35	266791	133576	90228045
Inappropriate schedule of product administration	272.16	26.98	55	266771	149878	90211743
Platelet count decreased	271.08	26.98	40	266786	136929	90224692
Lung disorder	269.85	26.98	1012	265814	148871	90212750
Cerebrovascular accident	269.32	26.98	26	266800	123507	90238114
Chest discomfort	267.93	26.98	43	266783	138322	90223299
Heart rate increased	265.05	26.98	17	266809	112885	90248736
Palpitations	259.19	26.98	45	266781	136683	90224938
Off label use	249.37	26.98	2065	264761	1100187	89261434
Pulmonary embolism	248.10	26.98	43	266783	130777	90230844
Sepsis	243.77	26.98	112	266714	179702	90181919
Cardiac failure	241.48	26.98	22	266804	109474	90252147
Inflammation	241.34	26.98	1104	265722	177488	90184133
Loss of consciousness	241.28	26.98	58	266768	140180	90221441
Pancytopenia	240.60	26.98	34	266792	120229	90241392
Wheezing	236.56	26.98	1350	265476	236730	90124891
Mobility decreased	235.04	26.98	1400	265426	249334	90112287
Disease progression	234.33	26.98	84	266742	156531	90205090
Injection site erythema	230.72	26.98	15	266811	98487	90263134
Renal impairment	230.31	26.98	22	266804	105399	90256222
General physical health deterioration	226.12	26.98	1803	265023	353312	90008309
Pulmonary fibrosis	224.37	26.98	762	266064	106741	90254880
Balance disorder	223.83	26.98	16	266810	97064	90264557
Oxygen saturation decreased	223.15	26.98	27	266799	107456	90254165
Drug abuse	222.13	26.98	4	266822	82343	90279278
C-reactive protein	220.91	26.98	359	266467	31008	90330613
Cardiac failure congestive	219.89	26.98	19	266807	98675	90262946
Oropharyngeal pain	215.95	26.98	39	266787	115148	90246473
Blood glucose increased	215.90	26.98	17	266809	95229	90266392
Liver disorder	215.09	26.98	815	266011	120454	90241167
Body temperature increased	214.38	26.98	433	266393	44277	90317344
Vision blurred	214.16	26.98	34	266792	110259	90251362
Pleural effusion	209.78	26.98	38	266788	111953	90249668
Incorrect dose administered	208.29	26.98	5	266821	78925	90282696
Gastrointestinal haemorrhage	207.71	26.98	15	266811	90233	90271388
Malignant neoplasm progression	207.38	26.98	33	266793	106837	90254784
Rash	206.95	26.98	3390	263436	792710	89568911
Thrombocytopenia	205.39	26.98	187	266639	208538	90153083
Respiratory failure	203.66	26.98	49	266777	118369	90243252
Osteoarthritis	199.09	26.98	1117	265709	194613	90167008
Febrile neutropenia	199.04	26.98	109	266717	158240	90203381
Suicide attempt	190.88	26.98	7	266819	75392	90286229
Interstitial lung disease	187.07	26.98	9	266817	76396	90285225
Depressed level of consciousness	186.92	26.98	6	266820	72778	90288843
Diarrhoea	184.34	26.98	1823	265003	937367	89424254
Cardiac arrest	183.27	26.98	42	266784	104893	90256728
Coma	182.99	26.98	7	266819	72625	90288996
Productive cough	182.68	26.98	11	266815	77052	90284569
Dysphagia	182.53	26.98	52	266774	112226	90249395
Illness	179.33	26.98	17	266809	81952	90279669
Herpes zoster	177.51	26.98	32	266794	94612	90267009
Rhinorrhoea	176.57	26.98	25	266801	88291	90273330
Blood creatinine increased	176.23	26.98	41	266785	101345	90260276
Influenza like illness	175.61	26.98	17	266809	80594	90281027
Nasal congestion	175.52	26.98	20	266806	83394	90278227
Prescribed underdose	174.70	26.98	552	266274	74467	90287154
Onychomadesis	174.22	26.98	405	266421	45593	90316028
Breast cancer stage II	173.95	26.98	346	266480	34988	90326633
Prescribed overdose	173.01	26.98	656	266170	96969	90264652
Bradycardia	171.76	26.98	22	266804	83825	90277796
Cognitive disorder	170.50	26.98	8	266818	69399	90292222
Wrong technique in product usage process	170.31	26.98	10	266816	71561	90290060
Bone erosion	170.14	26.98	438	266388	52583	90309038
Stress	170.06	26.98	20	266806	81375	90280246
Chronic obstructive pulmonary disease	167.83	26.98	13	266813	73816	90287805
Hypoglycaemia	162.51	26.98	11	266815	69837	90291784
Nail disorder	162.49	26.98	461	266365	58606	90303015
Suicidal ideation	162.41	26.98	15	266811	73840	90287781
Blood pressure decreased	160.02	26.98	17	266809	74878	90286743
Haematochezia	159.76	26.98	13	266813	70900	90290721
Maternal exposure timing unspecified	159.24	26.98	258	266568	22225	90339396
Electrocardiogram QT prolonged	158.58	26.98	15	266811	72441	90289180
Retinitis	158.32	26.98	350	266476	38108	90323513
Musculoskeletal pain	158.30	26.98	953	265873	170298	90191323
Abdominal pain upper	158.08	26.98	1585	265241	331089	90030532
Lupus vulgaris	157.98	26.98	385	266441	44674	90316947
Diabetes mellitus	157.68	26.98	8	266818	64867	90296754
Pyrexia	156.97	26.98	2773	264053	657712	89703909
Anti-cyclic citrullinated peptide antibody	156.79	26.98	285	266541	26936	90334685
Alanine aminotransferase increased	155.31	26.98	77	266749	118261	90243360
Cataract	154.96	26.98	16	266810	72076	90289545
Agitation	154.85	26.98	11	266815	67087	90294534
Live birth	154.84	26.98	549	266277	78558	90283063
Drug intolerance	154.31	26.98	2003	264823	445588	89916033
Swelling face	153.66	26.98	27	266799	81325	90280296
Septic shock	152.43	26.98	31	266795	84129	90277492
Hallucination	151.68	26.98	11	266815	65948	90295673
Deep vein thrombosis	151.60	26.98	41	266785	91579	90270042
Cellulitis	150.90	26.98	41	266785	91296	90270325
Cardiac disorder	148.55	26.98	4	266822	56868	90304753
Exostosis	147.43	26.98	416	266410	52718	90308903
Maternal exposure during pregnancy	145.67	26.98	1661	265165	358402	90003219
Dry skin	144.63	26.98	40	266786	88033	90273588
Cardio-respiratory arrest	143.85	26.98	11	266815	63129	90298492
Delirium	143.77	26.98	649	266177	103710	90257911
Vertigo	143.77	26.98	18	266808	69793	90291828
Flushing	141.97	26.98	42	266784	88449	90273172
Onychomycosis	141.45	26.98	329	266497	37047	90324574
Intentional product use issue	140.48	26.98	1106	265720	215786	90145835
Neuropathy peripheral	140.41	26.98	118	266708	136852	90224769
Oedema	140.14	26.98	1040	265786	199255	90162366
Burning sensation	139.22	26.98	13	266813	63439	90298182
Thrombosis	139.04	26.98	24	266802	73227	90288394
Dyspnoea exertional	138.72	26.98	23	266803	72265	90289356
Injection site swelling	137.54	26.98	10	266816	59829	90301792
Multiple organ dysfunction syndrome	137.42	26.98	19	266807	68317	90293304
Pneumonia	136.70	26.98	1211	265615	636848	89724773
Skin exfoliation	136.29	26.98	19	266807	67894	90293727
Medication error	135.54	26.98	551	266275	84101	90277520
Hyperkalaemia	133.18	26.98	17	266809	64947	90296674
Dysphonia	133.04	26.98	15	266811	63069	90298552
Angioedema	132.94	26.98	17	266809	64859	90296762
Hypoaesthesia	131.83	26.98	1460	265366	312750	90048871
Drug ineffective for unapproved indication	130.60	26.98	20	266806	66624	90294997
Walking aid user	130.51	26.98	309	266517	35197	90326424
Lupus-like syndrome	129.28	26.98	376	266450	48470	90313151
Aspartate aminotransferase increased	129.13	26.98	71	266755	102866	90258755
Metabolic acidosis	128.85	26.98	9	266817	55667	90305954
Rash erythematous	128.82	26.98	19	266807	65085	90296536
Leukopenia	128.47	26.98	68	266758	100642	90260979
Dysarthria	128.46	26.98	8	266818	54474	90307147
Product label confusion	127.52	26.98	236	266590	22614	90339007
Laryngitis	126.08	26.98	382	266444	50371	90311250
Multiple sclerosis relapse	125.40	26.98	7	266819	52298	90309323
Finger deformity	124.96	26.98	290	266536	32607	90329014
Hypokalaemia	124.79	26.98	121	266705	130995	90230626
Haemorrhage	124.70	26.98	26	266800	69343	90292278
Adverse event	124.59	26.98	678	266148	116740	90244881
Lactic acidosis	123.35	26.98	6	266820	50457	90311164
Myelosuppression	123.05	26.98	9	266817	53582	90308039
Amnesia	122.27	26.98	637	266189	107868	90253753
Cystitis	122.03	26.98	24	266802	66694	90294927
Throat irritation	121.62	26.98	5	266821	48690	90312931
Hip arthroplasty	121.18	26.98	495	266331	75713	90285908
Hepatic cirrhosis	120.39	26.98	435	266391	62818	90298803
Neutrophil count decreased	120.27	26.98	31	266795	71501	90290120
Sedation	120.13	26.98	5	266821	48166	90313455
Back pain	119.97	26.98	503	266323	316672	90044949
Blood pressure fluctuation	119.78	26.98	9	266817	52404	90309217
Lethargy	119.15	26.98	21	266805	63118	90298503
Bone pain	118.32	26.98	20	266806	61963	90299658
Hepatic function abnormal	118.20	26.98	4	266822	46284	90315337
Injection site pruritus	118.19	26.98	11	266815	53823	90307798
Pregnancy	117.49	26.98	426	266400	61621	90300000
Chronic kidney disease	116.48	26.98	8	266818	50183	90311438
Unevaluable event	115.77	26.98	13	266813	54835	90306786
Blood pressure systolic increased	115.50	26.98	17	266809	58328	90303293
Liver function test abnormal	115.43	26.98	9	266817	50836	90310785
Blepharospasm	114.75	26.98	392	266434	55053	90306568
Overdose	112.02	26.98	182	266644	157527	90204094
Porphyria acute	110.97	26.98	194	266632	17781	90343840
Therapy interrupted	110.65	26.98	10	266816	50098	90311523
Dry eye	107.74	26.98	20	266806	57911	90303710
Colitis	107.19	26.98	36	266790	69906	90291715
Dyspepsia	106.84	26.98	970	265856	197190	90164431
Hypothyroidism	106.29	26.98	15	266811	53112	90308509
Bronchitis	106.27	26.98	179	266647	152748	90208873
Dizziness	105.80	26.98	1167	265659	588117	89773504
International normalised ratio increased	105.68	26.98	9	266817	47307	90314314
Disturbance in attention	105.11	26.98	9	266817	47100	90314521
Drug reaction with eosinophilia and systemic symptoms	104.79	26.98	5	266821	42753	90318868
Flatulence	104.15	26.98	4	266822	41363	90320258
Fungal infection	101.38	26.98	6	266820	42655	90318966
Hypoxia	101.37	26.98	43	266783	72356	90289265
Nephrolithiasis	100.24	26.98	13	266813	49072	90312549
Musculoskeletal stiffness	99.94	26.98	1322	265504	295210	90066411
Intentional product misuse	99.69	26.98	71	266755	89533	90272088
Disorientation	99.61	26.98	8	266818	44106	90317515
Aphasia	98.84	26.98	7	266819	42805	90318816
Femur fracture	97.07	26.98	11	266815	46071	90315550
Swollen tongue	96.73	26.98	11	266815	45945	90315676
Pneumonia aspiration	96.56	26.98	6	266820	40934	90320687
Orthostatic hypotension	96.10	26.98	7	266819	41820	90319801
Speech disorder	95.72	26.98	11	266815	45574	90316047
Blood potassium decreased	94.26	26.98	14	266812	47713	90313908
Dyskinesia	93.85	26.98	3	266823	36531	90325090
Surgery	93.84	26.98	11	266815	44876	90316745
Cholelithiasis	93.72	26.98	20	266806	52486	90309135
Taste disorder	93.32	26.98	394	266432	61152	90300469
Restlessness	91.52	26.98	3	266823	35717	90325904
Haematocrit decreased	90.64	26.98	9	266817	41823	90319798
Red blood cell count decreased	90.62	26.98	14	266812	46337	90315284
Disease recurrence	90.38	26.98	5	266821	37648	90323973
Heart rate decreased	90.31	26.98	23	266803	53482	90308139
Ascites	89.82	26.98	16	266810	47724	90313897
Transient ischaemic attack	89.22	26.98	11	266815	43165	90318456
Generalised tonic-clonic seizure	89.18	26.98	3	266823	34900	90326721
Acute myocardial infarction	89.14	26.98	3	266823	34887	90326734
Intestinal obstruction	88.92	26.98	5	266821	37126	90324495
Hot flush	88.79	26.98	32	266794	59456	90302165
Haematoma	88.40	26.98	7	266819	39041	90322580
Urinary retention	87.63	26.98	6	266820	37738	90323883
Headache	87.46	26.98	1906	264920	860840	89500781
Tinnitus	86.62	26.98	12	266814	43090	90318531
Back injury	86.49	26.98	318	266508	46304	90315317
Weight decreased	86.14	26.98	710	266116	379200	89982421
Agranulocytosis	86.08	26.98	4	266822	34998	90326623
Breast cancer	85.35	26.98	26	266800	53735	90307886
Hepatic failure	84.91	26.98	9	266817	39719	90321902
Subcutaneous drug absorption impaired	84.68	26.98	147	266679	13398	90348223
Arrhythmia	84.57	26.98	12	266814	42320	90319301
Full blood count abnormal	84.44	26.98	6	266820	36591	90325030
Arthralgia	84.03	26.98	2937	263889	775585	89586036
Therapy cessation	83.78	26.98	6	266820	36355	90325266
Pallor	83.71	26.98	4	266822	34161	90327460
C-reactive protein increased	83.52	26.98	859	265967	180530	90181091
Nervousness	83.40	26.98	4	266822	34052	90327569
Gastritis	83.03	26.98	12	266814	41741	90319880
Epistaxis	82.81	26.98	77	266749	85048	90276573
Eye pain	82.67	26.98	15	266811	44153	90317468
Jaundice	82.36	26.98	3	266823	32514	90329107
Abdominal pain	81.55	26.98	758	266068	394963	89966658
Eczema	81.39	26.98	27	266799	52843	90308778
Sinus disorder	81.39	26.98	5	266821	34442	90327179
Angina pectoris	80.87	26.98	10	266816	39150	90322471
Transaminases increased	80.59	26.98	8	266818	37184	90324437
Plasma cell myeloma	80.58	26.98	12	266814	40816	90320805
Hyperglycaemia	80.29	26.98	25	266801	50945	90310676
Viral infection	79.85	26.98	13	266813	41401	90320220
Liver function test increased	79.49	26.98	474	266352	84381	90277240
Melaena	79.44	26.98	6	266820	34791	90326830
Acute respiratory failure	79.42	26.98	15	266811	42903	90318718
Toxic epidermal necrolysis	79.08	26.98	4	266822	32524	90329097
Procedural pain	78.35	26.98	5	266821	33355	90328266
Limb discomfort	77.91	26.98	10	266816	38050	90323571
Mental status changes	77.77	26.98	18	266808	44661	90316960
Joint dislocation	77.65	26.98	298	266528	44284	90317337
Blood creatine phosphokinase increased	77.30	26.98	6	266820	34017	90327604
Respiratory tract infection	76.66	26.98	39	266787	59039	90302582
Lymphadenopathy	76.64	26.98	20	266806	45755	90315866
Pulmonary hypertension	76.30	26.98	16	266810	42507	90319114
Oral herpes	75.92	26.98	6	266820	33518	90328103
Oral candidiasis	75.85	26.98	8	266818	35447	90326174
Knee arthroplasty	75.59	26.98	461	266365	82721	90278900
Vaginal haemorrhage	75.54	26.98	4	266822	31267	90330354
Mental disorder	75.44	26.98	5	266821	32313	90329308
Neoplasm progression	75.32	26.98	19	266807	44467	90317154
Pancreatitis acute	74.87	26.98	5	266821	32110	90329511
Pulmonary oedema	74.74	26.98	45	266781	62035	90299586
Pericardial effusion	74.63	26.98	10	266816	36823	90324798
Encephalopathy	74.57	26.98	22	266804	46422	90315199
Hemiparesis	74.04	26.98	5	266821	31814	90329807
Disability	73.98	26.98	276	266550	40469	90321152
Dysgeusia	73.93	26.98	31	266795	52529	90309092
Throat tightness	73.72	26.98	3	266823	29481	90332140
Paraesthesia oral	73.60	26.98	5	266821	31654	90329967
Unresponsive to stimuli	73.43	26.98	12	266814	38109	90323512
Hepatotoxicity	73.08	26.98	22	266804	45820	90315801
Clostridium difficile infection	73.05	26.98	10	266816	36235	90325386
Malaise	72.89	26.98	1250	265576	584736	89776885
Hepatic steatosis	72.59	26.98	11	266815	36934	90324687
Lymphocyte count decreased	72.26	26.98	9	266817	35041	90326580
Rash maculo-papular	72.23	26.98	16	266810	40917	90320704
Grip strength	71.99	26.98	109	266717	8856	90352765
Drug withdrawal syndrome	71.56	26.98	3	266823	28720	90332901
Hepatic cytolysis	71.53	26.98	5	266821	30911	90330710
Haematemesis	71.16	26.98	8	266818	33718	90327903
Full blood count decreased	71.09	26.98	4	266822	29685	90331936
Coronary artery disease	70.88	26.98	8	266818	33615	90328006
Blood bilirubin increased	70.88	26.98	20	266806	43450	90318171
Drug resistance	70.23	26.98	5	266821	30444	90331177
Haemoptysis	70.06	26.98	8	266818	33312	90328309
Skin disorder	69.71	26.98	12	266814	36694	90324927
Seronegative arthritis	69.53	26.98	161	266665	18073	90343548
Immunodeficiency	68.47	26.98	21	266805	43213	90318408
Sleep apnoea syndrome	68.34	26.98	7	266819	31740	90329881
Incorrect route of product administration	68.32	26.98	313	266513	50313	90311308
Joint injury	68.29	26.98	8	266818	32656	90328965
Hypocalcaemia	68.15	26.98	20	266806	42348	90319273
Acne	67.77	26.98	4	266822	28503	90333118
Device issue	67.70	26.98	5	266821	29532	90332089
Limb injury	67.69	26.98	7	266819	31501	90330120
Stevens-Johnson syndrome	67.25	26.98	5	266821	29371	90332250
General symptom	66.69	26.98	139	266687	14529	90347092
Abdominal pain lower	66.69	26.98	6	266820	30171	90331450
Product prescribing error	66.60	26.98	6	266820	30139	90331482
Mucosal inflammation	66.31	26.98	44	266782	57581	90304040
Multiple sclerosis	65.90	26.98	4	266822	27836	90333785
Cerebral infarction	65.53	26.98	3	266823	26593	90335028
Pneumonitis	65.51	26.98	24	266802	44146	90317475
Blood urea increased	64.71	26.98	7	266819	30406	90331215
Tachycardia	64.67	26.98	242	266584	157431	90204190
Hip fracture	64.64	26.98	10	266816	33067	90328554
Memory impairment	64.18	26.98	874	265952	196370	90165251
Mouth ulceration	64.06	26.98	19	266807	39955	90321666
Cerebral haemorrhage	64.02	26.98	12	266814	34510	90327111
Depressed mood	63.91	26.98	34	266792	50188	90311433
Migraine	63.75	26.98	848	265978	189544	90172077
Urinary incontinence	63.68	26.98	16	266810	37550	90324071
Localised infection	63.68	26.98	11	266815	33551	90328070
Accidental exposure to product	62.87	26.98	23	266803	42343	90319278
Crying	62.84	26.98	3	266823	25642	90335979
Diplopia	62.68	26.98	6	266820	28708	90332913
Blood sodium decreased	62.37	26.98	5	266821	27608	90334013
Neoplasm malignant	62.35	26.98	12	266814	33868	90327753
Gastroenteritis viral	62.08	26.98	8	266818	30347	90331274
Sinus congestion	61.84	26.98	5	266821	27419	90334202
Eye disorder	61.75	26.98	5	266821	27385	90334236
Gastric disorder	61.07	26.98	12	266814	33372	90328249
Respiratory arrest	60.88	26.98	12	266814	33299	90328322
Swollen joint count	60.87	26.98	99	266727	8554	90353067
Metastases to liver	60.36	26.98	7	266819	28800	90332821
Drug-induced liver injury	60.30	26.98	464	266362	89854	90271767
Acute respiratory distress syndrome	60.04	26.98	7	266819	28679	90332942
Head injury	59.66	26.98	10	266816	31178	90330443
Rash macular	59.52	26.98	9	266817	30271	90331350
Blindness	59.48	26.98	5	266821	26563	90335058
Blood calcium decreased	59.26	26.98	9	266817	30173	90331448
Epilepsy	59.23	26.98	430	266396	81776	90279845
Gastric ulcer	59.22	26.98	6	266820	27442	90334179
Dysuria	59.13	26.98	21	266805	39380	90322241
Haematuria	59.00	26.98	15	266811	34922	90326699
Eye irritation	58.52	26.98	14	266812	33964	90327657
Device dislocation	58.26	26.98	11	266815	31471	90330150
Dysstasia	58.11	26.98	4	266822	25048	90336573
Bone marrow failure	58.07	26.98	12	266814	32209	90329412
Ocular hyperaemia	58.07	26.98	14	266812	33784	90327837
Pollakiuria	58.04	26.98	13	266813	32992	90328629
Rash vesicular	58.03	26.98	150	266676	18047	90343574
Carpal tunnel syndrome	57.99	26.98	3	266823	23925	90337696
Foetal exposure during pregnancy	57.84	26.98	27	266799	42948	90318673
Hypoacusis	57.78	26.98	7	266819	27843	90333778
No adverse event	57.70	26.98	69	266757	67913	90293708
Eosinophilia	57.21	26.98	8	266818	28525	90333096
Eye pruritus	56.21	26.98	9	266817	29018	90332603
Eating disorder	55.98	26.98	8	266818	28065	90333556
Coeliac disease	55.95	26.98	270	266556	44340	90317281
Lung neoplasm malignant	55.94	26.98	4	266822	24269	90337352
Lip swelling	55.56	26.98	22	266804	38588	90323033
Blood alkaline phosphatase increased	54.93	26.98	37	266789	48042	90313579
Poor quality sleep	54.33	26.98	5	266821	24688	90336933
Iron deficiency anaemia	54.24	26.98	4	266822	23658	90337963
Acute hepatic failure	54.14	26.98	3	266823	22558	90339063
Anaphylactic reaction	54.09	26.98	110	266716	87414	90274207
Withdrawal syndrome	54.04	26.98	3	266823	22521	90339100
Restless legs syndrome	53.88	26.98	3	266823	22467	90339154
Palmar-plantar erythrodysaesthesia syndrome	53.57	26.98	9	266817	28014	90333607
Posterior reversible encephalopathy syndrome	53.52	26.98	3	266823	22336	90339285
Face oedema	53.29	26.98	4	266822	23314	90338307
Proteinuria	53.21	26.98	4	266822	23287	90338334
Foot deformity	53.19	26.98	329	266497	59322	90302299
Leukocytosis	52.92	26.98	13	266813	30977	90330644
Fracture	52.78	26.98	3	266823	22073	90339548
Chronic sinusitis	51.88	26.98	5	266821	23797	90337824
Irritability	51.85	26.98	20	266806	35642	90325979
Ventricular tachycardia	51.78	26.98	6	266820	24702	90336919
Product administration error	51.61	26.98	8	266818	26415	90335206
Upper limb fracture	51.38	26.98	3	266823	21575	90340046
Shock	51.28	26.98	11	266815	28767	90332854
Hypersomnia	51.25	26.98	3	266823	21528	90340093
Pain in jaw	50.82	26.98	40	266786	47945	90313676
Injection site rash	50.34	26.98	6	266820	24167	90337454
Pustular psoriasis	50.21	26.98	144	266682	18412	90343209
Accidental overdose	49.99	26.98	11	266815	28262	90333359
Cytomegalovirus infection	49.86	26.98	9	266817	26593	90335028
Skin discolouration	49.44	26.98	35	266791	44280	90317341
Mood swings	48.92	26.98	3	266823	20699	90340922
Vasculitis	48.86	26.98	5	266821	22688	90338933
Pulmonary arterial hypertension	48.78	26.98	9	266817	26178	90335443
Bacterial infection	48.38	26.98	6	266820	23438	90338183
Blood pressure diastolic decreased	48.32	26.98	10	266816	26816	90334805
Premature baby	48.06	26.98	8	266818	25069	90336552
Haemorrhoids	48.00	26.98	10	266816	26692	90334929
Skin ulcer	47.87	26.98	46	266780	50029	90311592
Treatment noncompliance	47.75	26.98	49	266777	51678	90309943
Product storage error	47.63	26.98	3	266823	20238	90341383
Rib fracture	47.32	26.98	10	266816	26425	90335196
Pharyngitis	46.83	26.98	5	266821	21942	90339679
Candida infection	46.45	26.98	21	266805	34036	90327585
Adverse reaction	46.43	26.98	192	266634	29520	90332101
Gallbladder disorder	46.41	26.98	3	266823	19800	90341821
Glaucoma	46.21	26.98	4	266822	20751	90340870
Presyncope	45.97	26.98	18	266808	31787	90329834
Ankle fracture	45.15	26.98	4	266822	20366	90341255
Hypervolaemia	44.99	26.98	20	266806	32737	90328884
Ejection fraction decreased	44.86	26.98	11	266815	26242	90335379
Hypophagia	44.75	26.98	25	266801	35912	90325709
Hyperlipidaemia	44.62	26.98	7	266819	22909	90338712
Rash pruritic	44.55	26.98	111	266715	82103	90279518
Therapeutic response shortened	44.52	26.98	7	266819	22872	90338749
Respiratory distress	44.45	26.98	30	266796	38916	90322705
Skin laceration	44.31	26.98	11	266815	26024	90335597
Pain in extremity	44.14	26.98	1000	265826	449529	89912092
Myelodysplastic syndrome	44.00	26.98	5	266821	20898	90340723
Intervertebral disc protrusion	43.45	26.98	13	266813	27183	90334438
Impaired quality of life	43.01	26.98	8	266818	23136	90338485
Heavy menstrual bleeding	42.99	26.98	5	266821	20525	90341096
Ischaemic stroke	42.64	26.98	7	266819	22159	90339462
Neutrophil count increased	42.46	26.98	4	266822	19386	90342235
Gamma-glutamyltransferase increased	42.30	26.98	30	266796	37922	90323699
Cardiogenic shock	42.30	26.98	10	266816	24458	90337163
Spondylitis	42.29	26.98	114	266712	14064	90347557
Hyperthyroidism	42.25	26.98	3	266823	18307	90343314
Spinal fracture	42.25	26.98	7	266819	22009	90339612
Motor dysfunction	42.02	26.98	4	266822	19226	90342395
Foot fracture	41.99	26.98	13	266813	26593	90335028
Retching	41.83	26.98	4	266822	19155	90342466
Red blood cell sedimentation rate increased	41.80	26.98	399	266427	82196	90279425
Red blood cell sedimentation rate abnormal	41.63	26.98	10	266816	24194	90337427
Hepatic enzyme	41.54	26.98	64	266762	5280	90356341
Post procedural complication	41.51	26.98	4	266822	19038	90342583
Nightmare	41.48	26.98	7	266819	21718	90339903
Product substitution issue	41.41	26.98	3	266823	18005	90343616
Hypomagnesaemia	41.18	26.98	27	266799	35561	90326060
Subarachnoid haemorrhage	41.12	26.98	3	266823	17901	90343720
Disseminated intravascular coagulation	40.99	26.98	7	266819	21531	90340090
Infusion site pain	40.85	26.98	5	266821	19733	90341888
Coordination abnormal	40.52	26.98	7	266819	21349	90340272
Conjunctivitis	40.48	26.98	14	266812	26692	90334929
Basal cell carcinoma	40.47	26.98	24	266802	33365	90328256
Pyelonephritis	40.41	26.98	7	266819	21309	90340312
Underdose	40.32	26.98	285	266541	53732	90307889
Poor venous access	40.29	26.98	5	266821	19522	90342099
Ulcer haemorrhage	40.28	26.98	169	266657	26152	90335469
Rash papular	40.13	26.98	6	266820	20349	90341272
Injection site warmth	40.04	26.98	3	266823	17512	90344109
Skin lesion	39.76	26.98	31	266795	37334	90324287
Visual acuity reduced	39.63	26.98	10	266816	23400	90338221
Blood test abnormal	39.46	26.98	7	266819	20945	90340676
Drug eruption	39.45	26.98	28	266798	35379	90326242
Myositis	39.36	26.98	158	266668	23970	90337651
Oesophagitis	39.30	26.98	3	266823	17246	90344375
Oral pain	38.91	26.98	24	266802	32659	90328962
Ataxia	38.78	26.98	4	266822	18038	90343583
Tachypnoea	38.27	26.98	8	266818	21301	90340320
Photosensitivity reaction	38.14	26.98	4	266822	17803	90343818
Overlap syndrome	37.69	26.98	80	266746	8468	90353153
Radiculopathy	37.54	26.98	5	266821	18500	90343121
Vitamin D deficiency	37.46	26.98	4	266822	17552	90344069
Coagulopathy	37.44	26.98	11	266815	23278	90338343
Impaired work ability	37.41	26.98	6	266820	19320	90342301
Deafness	37.38	26.98	10	266816	22504	90339117
Hiatus hernia	37.24	26.98	14	266812	25347	90336274
Clostridium difficile colitis	37.16	26.98	16	266810	26690	90334931
Nodule	37.11	26.98	16	266810	26670	90334951
Adrenal insufficiency	36.99	26.98	21	266805	29900	90331721
Nervous system disorder	36.98	26.98	9	266817	21584	90340037
Bronchospasm	36.73	26.98	8	266818	20701	90340920
Extrapyramidal disorder	36.69	26.98	3	266823	16300	90345321
Cardiomegaly	36.35	26.98	6	266820	18919	90342702
Ear infection	36.27	26.98	339	266487	69436	90292185
Staphylococcal infection	36.19	26.98	54	266772	48385	90313236
Joint stiffness	36.08	26.98	370	266456	77672	90283949
Tenderness	35.97	26.98	17	266809	26851	90334770
Skin burning sensation	35.97	26.98	7	266819	19604	90342017
Therapy non-responder	35.94	26.98	584	266242	136120	90225501
Glomerular filtration rate decreased	35.76	26.98	4	266822	16928	90344693
Back disorder	35.72	26.98	160	266666	25471	90336150
Intentional dose omission	35.62	26.98	5	266821	17778	90343843
Uveitis	35.58	26.98	3	266823	15900	90345721
Rhinitis allergic	35.37	26.98	4	266822	16781	90344840
Polyneuropathy	35.28	26.98	7	266819	19334	90342287
Osteopenia	34.96	26.98	12	266814	22990	90338631
Lacrimation increased	34.91	26.98	18	266808	27044	90334577
Toothache	34.84	26.98	11	266815	22219	90339402
Cyst	34.76	26.98	4	266822	16557	90345064
Ileus	34.72	26.98	4	266822	16542	90345079
Glycosylated haemoglobin increased	34.64	26.98	3	266823	15559	90346062
Vomiting	34.49	26.98	1934	264892	786359	89575262
Dermatitis atopic	34.39	26.98	13	266813	23459	90338162
Small intestinal obstruction	34.19	26.98	10	266816	21224	90340397
Abscess	34.12	26.98	7	266819	18884	90342737
Thirst	34.04	26.98	4	266822	16291	90345330
Aggression	34.01	26.98	18	266808	26650	90334971
Anal incontinence	33.87	26.98	4	266822	16226	90345395
Sinus tachycardia	33.86	26.98	21	266805	28492	90333129
Mitral valve incompetence	33.81	26.98	12	266814	22512	90339109
Musculoskeletal disorder	33.71	26.98	11	266815	21758	90339863
Cholecystitis	33.64	26.98	5	266821	17035	90344586
Spinal compression fracture	33.59	26.98	3	266823	15175	90346446
Seasonal allergy	33.23	26.98	13	266813	22970	90338651
Secretion discharge	32.97	26.98	4	266822	15892	90345729
Ulcer	32.86	26.98	29	266797	32853	90328768
Metastases to central nervous system	32.74	26.98	6	266820	17536	90344085
Pseudomonas infection	32.73	26.98	3	266823	14862	90346759
Therapeutic product effect incomplete	32.72	26.98	389	266437	193507	90168114
Feeding disorder	32.66	26.98	6	266820	17506	90344115
Subdural haematoma	32.60	26.98	5	266821	16640	90344981
Photophobia	32.49	26.98	11	266815	21258	90340363
Spinal stenosis	32.43	26.98	6	266820	17418	90344203
Bone density decreased	32.22	26.98	6	266820	17339	90344282
Renal tubular necrosis	31.88	26.98	3	266823	14552	90347069
Feeling jittery	31.55	26.98	4	266822	15367	90346254
Pelvic pain	31.52	26.98	4	266822	15353	90346268
Skin fissures	31.38	26.98	11	266815	20798	90340823
Malnutrition	31.27	26.98	8	266818	18550	90343071
Pelvic fracture	31.15	26.98	4	266822	15215	90346406
Poisoning	31.14	26.98	4	266822	15213	90346408
Flank pain	31.05	26.98	9	266817	19213	90342408
Right ventricular failure	31.01	26.98	9	266817	19196	90342425
Hypercalcaemia	30.97	26.98	33	266793	34207	90327414
Escherichia infection	30.62	26.98	5	266821	15890	90345731
Mental impairment	30.60	26.98	6	266820	16714	90344907
Ventricular fibrillation	30.48	26.98	3	266823	14041	90347580
Normal newborn	30.46	26.98	143	266683	23219	90338402
Joint effusion	30.45	26.98	10	266816	19700	90341921
Cytopenia	30.42	26.98	7	266819	17442	90344179
Electrolyte imbalance	30.32	26.98	16	266810	23729	90337892
Blood pressure abnormal	30.29	26.98	10	266816	19635	90341986
Brain oedema	30.26	26.98	7	266819	17378	90344243
Needle issue	30.18	26.98	3	266823	13931	90347690
Circulatory collapse	30.05	26.98	18	266808	24886	90336735
Intestinal perforation	30.04	26.98	3	266823	13878	90347743
Neuralgia	30.04	26.98	29	266797	31471	90330150
Cardiomyopathy	29.93	26.98	11	266815	20195	90341426
Muscle twitching	29.90	26.98	17	266809	24185	90337436
Therapeutic response decreased	29.87	26.98	149	266677	89580	90272041
Complication associated with device	29.82	26.98	10	266816	19439	90342182
Facial paralysis	29.67	26.98	5	266821	15529	90346092
Ligament sprain	29.49	26.98	4	266822	14595	90347026
Infusion site erythema	29.46	26.98	3	266823	13667	90347954
Labelled drug-drug interaction medication error	29.44	26.98	4	266822	14578	90347043
Product quality issue	29.36	26.98	360	266466	78965	90282656
Lymphoma	29.25	26.98	3	266823	13588	90348033
Cardiovascular disorder	28.98	26.98	3	266823	13489	90348132
Upper respiratory tract infection	28.94	26.98	240	266586	128078	90233543
Osteonecrosis	28.91	26.98	21	266805	26220	90335401
Muscle tightness	28.83	26.98	3	266823	13436	90348185
Incontinence	28.82	26.98	3	266823	13432	90348189
Torsade de pointes	28.75	26.98	5	266821	15177	90346444
Hallucination, auditory	28.68	26.98	6	266820	15969	90345652
Premature labour	28.66	26.98	3	266823	13373	90348248
Upper-airway cough syndrome	28.63	26.98	5	266821	15130	90346491
Rotator cuff syndrome	28.54	26.98	6	266820	15913	90345708
Emotional distress	28.24	26.98	40	266786	36622	90324999
Mania	28.22	26.98	4	266822	14120	90347501
Spinal pain	28.15	26.98	6	266820	15761	90345860
Aphthous ulcer	28.10	26.98	8	266818	17279	90344342
Skin infection	27.71	26.98	9	266817	17855	90343766
Musculoskeletal chest pain	27.50	26.98	18	266808	23732	90337889
Splenomegaly	27.43	26.98	3	266823	12921	90348700
Escherichia urinary tract infection	27.40	26.98	4	266822	13811	90347810
Gangrene	27.30	26.98	3	266823	12873	90348748
Pharyngeal oedema	27.28	26.98	4	266822	13767	90347854
Generalised oedema	27.18	26.98	11	266815	19042	90342579

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic reaction	247.22	14.66	150	11347	42593	42567245
Burkholderia test positive	193.63	14.66	47	11450	1003	42608835
Recalled product administered	131.36	14.66	32	11465	693	42609145
Product contamination microbial	130.28	14.66	32	11465	718	42609120
Burkholderia infection	122.46	14.66	22	11475	93	42609745
Osteonecrosis of jaw	92.73	14.66	60	11437	18989	42590849
Burkholderia cepacia complex infection	83.07	14.66	19	11478	310	42609528
Recalled product	79.47	14.66	19	11478	379	42609459
Mechanical ventilation complication	78.03	14.66	21	11476	683	42609155
Anaphylactic shock	76.81	14.66	58	11439	23459	42586379
Respiratory tract infection bacterial	68.74	14.66	24	11473	1885	42607953
Sputum culture positive	62.81	14.66	22	11475	1744	42608094
Respiratory tract infection viral	58.53	14.66	25	11472	3381	42606457
Inspiratory capacity decreased	48.43	14.66	21	11476	2946	42606892
Haemothorax	48.28	14.66	25	11472	5211	42604627
Cytokine release syndrome	45.43	14.66	58	11439	44469	42565369
Adverse reaction	42.47	14.66	21	11476	3972	42605866
Hypotension	42.44	14.66	159	11338	257472	42352366
Chemical burn of skin	41.62	14.66	7	11490	18	42609820
Angiopathy	39.29	14.66	22	11475	5355	42604483
Drug interaction	38.68	14.66	12	11485	266987	42342851
Culture positive	37.22	14.66	12	11485	737	42609101
Hypovolaemia	36.77	14.66	28	11469	11457	42598381
Suspected transmission of an infectious agent via product	34.37	14.66	12	11485	942	42608896
Epistaxis	33.95	14.66	63	11434	66763	42543075
Emphysema	33.86	14.66	27	11470	11808	42598030
Face oedema	32.48	14.66	28	11469	13638	42596200
Tachycardia	29.27	14.66	76	11421	101011	42508827
Sensitisation	29.21	14.66	8	11489	278	42609560
Pain in jaw	29.09	14.66	27	11470	14475	42595363
Shock haemorrhagic	26.50	14.66	27	11470	16215	42593623
Off label use	26.12	14.66	87	11410	638248	41971590
Drug ineffective	25.70	14.66	86	11411	630111	41979727
Capillary nail refill test abnormal	24.80	14.66	5	11492	43	42609795
Pneumothorax	24.53	14.66	31	11466	23512	42586326
Osteomyelitis	23.93	14.66	27	11470	18196	42591642
Dermatitis contact	23.93	14.66	15	11482	4488	42605350
Hypersensitivity	23.66	14.66	57	11440	72313	42537525
Osteonecrosis	23.42	14.66	25	11472	15840	42593998
Respiratory tract infection	23.31	14.66	32	11465	26290	42583548
Chemical burn	23.18	14.66	7	11490	346	42609492
Bone disorder	23.12	14.66	17	11480	6596	42603242
Jaw disorder	22.04	14.66	11	11486	2122	42607716
Corneal epithelium defect	21.95	14.66	7	11490	415	42609423
Steroid diabetes	21.74	14.66	12	11485	2840	42606998
Tooth disorder	21.55	14.66	21	11476	11958	42597880
Stomatitis	20.19	14.66	43	11454	50286	42559552
Exposed bone in jaw	18.83	14.66	9	11488	1580	42608258
Postoperative wound infection	18.60	14.66	14	11483	5628	42604210
Cardiac arrest	18.37	14.66	68	11429	109252	42500586
Oral disorder	18.26	14.66	13	11484	4799	42605039
Neutropenic sepsis	18.22	14.66	22	11475	15924	42593914
Anterior chamber inflammation	18.16	14.66	6	11491	398	42609440
Gingivitis	18.07	14.66	12	11485	3961	42605877
Serum procollagen type III N-terminal propeptide increased	18.06	14.66	4	11493	56	42609782
Application site reaction	17.99	14.66	6	11491	410	42609428
Transmission of an infectious agent via product	17.96	14.66	5	11492	185	42609653
Serratia infection	17.56	14.66	8	11489	1261	42608577
Catheter site discharge	17.36	14.66	7	11490	818	42609020
Toxicity to various agents	17.15	14.66	22	11475	229114	42380724
Respiratory distress	17.08	14.66	36	11461	41784	42568054
Catheter site rash	16.90	14.66	5	11492	230	42609608
Thrombocytopenia	16.80	14.66	98	11399	190181	42419657
Keratic precipitates	16.80	14.66	5	11492	235	42609603
Lip haemorrhage	16.63	14.66	7	11490	913	42608925
Product quality issue	16.22	14.66	22	11475	17860	42591978
Corneal oedema	16.04	14.66	8	11489	1540	42608298
Febrile neutropenia	15.98	14.66	95	11402	185608	42424230
Flatulence	15.73	14.66	26	11471	25126	42584712
Vascular device infection	15.50	14.66	13	11484	6097	42603741
Catheter site irritation	15.20	14.66	4	11493	119	42609719
Peri-implantitis	14.95	14.66	4	11493	127	42609711
Loose tooth	14.84	14.66	7	11490	1194	42608644
Somnolence	14.73	14.66	10	11487	141095	42468743

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Folliculitis	2393.19	23.46	2273	222080	165380	110199566
Muscle injury	2043.19	23.46	1927	222426	138880	110226066
Irritable bowel syndrome	2007.34	23.46	2046	222307	162169	110202777
Sleep disorder due to general medical condition, insomnia type	1906.04	23.46	1635	222718	104008	110260938
Impaired healing	1903.80	23.46	2166	222187	194551	110170395
Helicobacter infection	1901.36	23.46	2085	222268	179792	110185154
Duodenal ulcer perforation	1831.31	23.46	2022	222331	175678	110189268
Hand deformity	1642.58	23.46	2117	222236	216389	110148557
Glossodynia	1636.26	23.46	2130	222223	219874	110145072
Lower respiratory tract infection	1616.54	23.46	2218	222135	240888	110124058
Ill-defined disorder	1579.97	23.46	1764	222589	155089	110209857
Blister	1500.24	23.46	2067	222286	225309	110139637
Stomatitis	1494.46	23.46	2259	222094	267983	110096963
Anti-cyclic citrullinated peptide antibody positive	1447.70	23.46	1814	222539	180170	110184776
Pemphigus	1444.79	23.46	1970	222383	212600	110152346
Systemic lupus erythematosus	1430.32	23.46	2143	222210	252195	110112751
Pericarditis	1429.14	23.46	1981	222372	217133	110147813
Wound	1396.96	23.46	2030	222323	232407	110132539
Synovitis	1308.46	23.46	2142	222211	271950	110092996
Gastrointestinal disorder	1210.68	23.46	1932	222421	240020	110124926
Hepatic enzyme increased	1095.17	23.46	2167	222186	318725	110046221
Discomfort	1092.58	23.46	1728	222625	212979	110151967
Arthropathy	1052.20	23.46	2000	222353	285522	110079424
Sinusitis	1004.30	23.46	1997	222356	294691	110070255
Lip dry	977.05	23.46	1108	223245	98975	110265971
Swelling	974.80	23.46	2179	222174	348862	110016084
Joint swelling	915.75	23.46	2454	221899	440391	109924555
Rheumatic fever	911.14	23.46	1182	223171	121397	110243549
Rheumatoid arthritis	910.48	23.46	1929	222424	297684	110067262
Facet joint syndrome	909.77	23.46	1051	223302	95777	110269169
Hypersensitivity	846.41	23.46	2250	222103	401748	109963198
Drug interaction	844.28	23.46	41	224312	500142	109864804
Alopecia	808.50	23.46	2075	222278	362678	110002268
Night sweats	808.48	23.46	1168	223185	132815	110232131
C-reactive protein abnormal	806.61	23.46	1147	223206	128548	110236398
Joint range of motion decreased	786.63	23.46	1097	223256	120735	110244211
Type 2 diabetes mellitus	777.97	23.46	1335	223018	175897	110189049
Toxicity to various agents	769.47	23.46	53	224300	480502	109884444
Injury	767.29	23.46	1327	223026	175938	110189008
Contusion	757.22	23.46	1544	222809	231817	110133129
Infusion related reaction	752.27	23.46	2077	222276	379085	109985861
Fibromyalgia	745.71	23.46	1284	223069	169625	110195321
Acute kidney injury	738.02	23.46	190	224163	635240	109729706
Weight increased	726.99	23.46	2182	222171	417462	109947484
Peripheral swelling	724.74	23.46	2127	222226	401907	109963039
Psoriatic arthropathy	719.50	23.46	1369	222984	195392	110169554
Therapeutic product effect decreased	708.51	23.46	1544	222809	242772	110122174
Abdominal discomfort	695.46	23.46	2062	222291	391796	109973150
Peripheral venous disease	673.63	23.46	842	223511	83275	110281671
Deep vein thrombosis postoperative	668.05	23.46	708	223645	58583	110306363
Nasopharyngitis	643.13	23.46	2008	222345	392353	109972593
Bursitis	626.52	23.46	1021	223332	128897	110236049
Anaemia	615.42	23.46	174	224179	546912	109818034
Autoimmune disorder	613.60	23.46	710	223643	64773	110300173
Swollen joint count increased	607.86	23.46	798	223555	82863	110282083
Rheumatoid factor positive	603.17	23.46	1011	223342	130629	110234317
Cough	592.47	23.46	110	224243	461531	109903415
Infection	591.14	23.46	1845	222508	360355	110004591
Death	580.73	23.46	350	224003	698519	109666427
Contraindicated product administered	579.39	23.46	1441	222912	246826	110118120
Confusional state	570.61	23.46	2165	222188	466515	109898431
Road traffic accident	570.12	23.46	882	223471	106516	110258430
Blood cholesterol increased	555.17	23.46	1185	223168	183600	110181346
Liver injury	536.68	23.46	1036	223317	149377	110215569
Lower limb fracture	529.33	23.46	707	223646	74641	110290305
Sleep disorder	510.53	23.46	1197	223156	197447	110167499
Maternal exposure during pregnancy	504.29	23.46	1391	222962	253492	110111454
Gait inability	502.12	23.46	952	223401	135424	110229522
Urticaria	500.62	23.46	1603	222750	317254	110047692
Dry mouth	493.44	23.46	1186	223167	198762	110166184
Obesity	493.37	23.46	851	223502	112500	110252446
Sciatica	482.25	23.46	753	223600	91646	110273300
Grip strength decreased	477.64	23.46	695	223658	79479	110285467
Product dose omission issue	475.15	23.46	50	224303	321732	110043214
Completed suicide	469.00	23.46	4	224349	242377	110122569
Breast cancer stage III	467.21	23.46	683	223670	78434	110286512
Hypotension	455.34	23.46	248	224105	523601	109841345
Wound infection	454.01	23.46	750	223603	95715	110269231
Inflammation	424.96	23.46	1097	223256	192141	110172805
Fall	411.98	23.46	371	223982	603111	109761835
Adjustment disorder with depressed mood	411.37	23.46	476	223877	43407	110321539
X-ray abnormal	409.64	23.46	444	223909	37673	110327273
Somnolence	405.60	23.46	60	224293	297389	110067557
Dehydration	403.61	23.46	47	224306	279464	110085482
Mobility decreased	392.06	23.46	1215	223138	236207	110128739
Osteoarthritis	384.42	23.46	1020	223333	181603	110183343
Drug intolerance	384.20	23.46	1738	222615	404774	109960172
Nausea	383.57	23.46	1260	223093	1234430	109130516
Lung disorder	382.43	23.46	1009	223344	179038	110185908
Constipation	367.93	23.46	133	224220	357653	110007293
Neutropenia	362.58	23.46	153	224200	374467	109990479
Dislocation of vertebra	353.65	23.46	440	223913	43281	110321665
Hypercholesterolaemia	346.55	23.46	644	223709	90193	110274753
Drug abuse	342.84	23.46	3	224350	177408	110187538
Renal failure	329.83	23.46	37	224316	226537	110138409
Pruritus	328.84	23.46	2161	222192	579399	109785547
C-reactive protein	327.13	23.46	354	223999	29977	110334969
Myalgia	322.00	23.46	37	224316	222344	110142602
Myocardial infarction	316.64	23.46	18	224335	192065	110172881
Urinary tract infection	316.12	23.46	133	224220	326149	110038797
Musculoskeletal pain	315.47	23.46	951	223402	182072	110182874
Wheezing	304.16	23.46	1172	223181	254058	110110888
Haemoglobin decreased	302.74	23.46	67	224286	248660	110116286
Blood pressure increased	299.92	23.46	77	224276	258296	110106650
Liver disorder	290.71	23.46	786	223567	141457	110223489
Nail disorder	282.74	23.46	458	223895	57477	110307469
Live birth	281.95	23.46	506	223847	68978	110295968
Seizure	280.73	23.46	54	224299	221131	110143815
Onychomadesis	279.42	23.46	401	223952	45262	110319684
Atrial fibrillation	277.19	23.46	63	224290	229579	110135367
COVID-19	276.94	23.46	77	224276	244983	110119963
Ear pain	275.17	23.46	432	223921	52794	110312152
Hyperhidrosis	274.08	23.46	30	224323	187268	110177678
Hyponatraemia	268.19	23.46	57	224296	217596	110147350
Syncope	266.66	23.46	45	224308	202491	110162455
Tremor	263.91	23.46	46	224307	202186	110162760
Renal impairment	263.89	23.46	35	224318	188410	110176536
Pregnancy	263.34	23.46	414	223939	50653	110314293
Cardiac failure	257.66	23.46	37	224316	187589	110177357
Insomnia	257.11	23.46	1424	222929	359166	110005780
Injection site pain	254.10	23.46	31	224322	177891	110187055
Respiratory disorder	247.51	23.46	486	223867	70896	110294050
Maternal exposure timing unspecified	247.44	23.46	257	224096	20756	110344190
Sepsis	245.73	23.46	183	224170	327163	110037783
Off label use	245.08	23.46	1913	222440	1498272	108866674
Feeling abnormal	245.00	23.46	37	224316	180674	110184272
Disease progression	243.60	23.46	95	224258	243939	110121007
Inappropriate schedule of product administration	243.50	23.46	57	224296	203580	110161366
Interstitial lung disease	242.81	23.46	9	224344	139325	110225621
Pulmonary fibrosis	241.60	23.46	596	223757	101446	110263500
Cerebrovascular accident	241.50	23.46	39	224314	181245	110183701
Chills	240.84	23.46	47	224306	190533	110174413
White blood cell count decreased	237.88	23.46	84	224269	229306	110135640
Erythema	233.22	23.46	152	224201	291295	110073651
Pancytopenia	231.05	23.46	69	224284	209544	110155402
Hypoaesthesia	226.68	23.46	1245	223108	312978	110051968
Onychomycosis	225.03	23.46	331	224022	38200	110326746
Gastrointestinal haemorrhage	224.13	23.46	34	224319	165484	110199462
Febrile neutropenia	224.01	23.46	188	224165	316579	110048367
Prescribed overdose	223.92	23.46	527	223826	87054	110277892
Influenza	219.46	23.46	39	224314	169062	110195884
Pulmonary embolism	214.87	23.46	83	224270	214391	110150555
Malignant neoplasm progression	214.47	23.46	46	224307	174521	110190425
Muscle spasticity	213.32	23.46	311	224042	35604	110329342
Rash	212.60	23.46	2571	221782	818393	109546553
Chest discomfort	211.17	23.46	47	224306	173801	110191145
Platelet count decreased	210.51	23.46	102	224251	230341	110134605
Lupus vulgaris	209.43	23.46	299	224054	33584	110331362
Abdominal pain upper	209.04	23.46	1317	223036	347794	110017152
Loss of consciousness	208.53	23.46	69	224284	196237	110168709
Retinitis	206.80	23.46	290	224063	32037	110332909
Finger deformity	205.98	23.46	293	224060	32799	110332147
Heart rate increased	205.53	23.46	25	224328	143809	110221137
Adverse event	204.24	23.46	583	223770	108226	110256720
Coma	204.06	23.46	8	224345	117861	110247085
Respiratory failure	203.36	23.46	91	224262	215241	110149705
Musculoskeletal stiffness	203.33	23.46	1111	223242	278711	110086235
Blepharospasm	203.07	23.46	384	223969	54467	110310479
Cardiac failure congestive	199.97	23.46	33	224320	150967	110213979
Rhabdomyolysis	199.28	23.46	11	224342	120390	110244556
Blood creatinine increased	198.31	23.46	62	224291	182827	110182119
Product label confusion	197.60	23.46	237	224116	22440	110342506
Bone erosion	196.23	23.46	344	224009	46027	110318919
Bradycardia	193.06	23.46	40	224313	155477	110209469
Palpitations	191.46	23.46	44	224309	159168	110205778
Blood glucose increased	189.39	23.46	23	224330	132473	110232473
Thrombocytopenia	188.86	23.46	259	224094	348626	110016320
Suicide attempt	186.17	23.46	5	224348	103389	110261557
Balance disorder	185.87	23.46	13	224340	116547	110248399
Haematochezia	183.88	23.46	13	224340	115511	110249435
Depressed level of consciousness	183.55	23.46	11	224342	112267	110252679
Drug ineffective	183.32	23.46	2090	222263	1518450	108846496
General physical health deterioration	179.58	23.46	1475	222878	423820	109941126
Incorrect dose administered	179.53	23.46	7	224346	103634	110261312
Hyperkalaemia	179.10	23.46	30	224323	135766	110229180
Productive cough	178.70	23.46	14	224339	114291	110250655
Oxygen saturation decreased	177.92	23.46	49	224304	156933	110208013
Prescribed underdose	177.40	23.46	402	223951	64772	110300174
Agitation	176.30	23.46	14	224339	113037	110251909
Multiple organ dysfunction syndrome	174.49	23.46	46	224307	151664	110213282
Vision blurred	173.54	23.46	27	224326	128995	110235951
Lupus-like syndrome	173.11	23.46	303	224050	40489	110324457
Exostosis	171.70	23.46	323	224030	45633	110319313
Hip arthroplasty	168.62	23.46	359	223994	55454	110309492
Breast cancer stage II	168.35	23.46	241	224112	27134	110337812
Porphyria acute	166.48	23.46	198	224155	18582	110346364
Anti-cyclic citrullinated peptide antibody	166.39	23.46	204	224149	19760	110345186
Cardiac arrest	165.14	23.46	97	224256	196656	110168290
Hypoglycaemia	163.88	23.46	21	224332	116083	110248863
Chronic obstructive pulmonary disease	163.50	23.46	16	224337	109142	110255804
Cardio-respiratory arrest	163.38	23.46	21	224332	115815	110249131
Taste disorder	162.31	23.46	389	223964	64998	110299948
Diabetes mellitus	161.66	23.46	10	224343	99371	110265575
Laryngitis	158.34	23.46	298	224055	42113	110322833
Deep vein thrombosis	157.90	23.46	44	224309	139843	110225103
Pleural effusion	157.26	23.46	82	224271	177627	110187319
Migraine	155.93	23.46	726	223627	170926	110194020
Electrocardiogram QT prolonged	155.51	23.46	19	224334	108941	110256005
Oedema	152.00	23.46	833	223520	209143	110155803
Oropharyngeal pain	151.85	23.46	43	224310	135233	110229713
Back injury	151.49	23.46	312	224041	47087	110317859
Cognitive disorder	151.28	23.46	6	224347	87505	110277441
Metabolic acidosis	151.04	23.46	14	224339	99730	110265216
Intentional product use issue	149.39	23.46	937	223416	246969	110117977
Dysphagia	146.44	23.46	64	224289	153536	110211410
Dyspepsia	145.97	23.46	769	223584	190196	110174750
Suicidal ideation	145.46	23.46	12	224341	93925	110271021
Septic shock	144.95	23.46	69	224284	157459	110207487
Rhinorrhoea	143.87	23.46	19	224334	102647	110262299
Myelosuppression	143.50	23.46	13	224340	94327	110270619
Injection site erythema	143.19	23.46	13	224340	94163	110270783
Pneumonia	142.51	23.46	1118	223235	875596	109489350
Stress	139.53	23.46	23	224330	105325	110259621
Alanine aminotransferase increased	138.78	23.46	102	224251	183671	110181275
Nasal congestion	138.17	23.46	18	224335	98264	110266682
Lactic acidosis	137.97	23.46	14	224339	92797	110272149
Diarrhoea	137.46	23.46	1565	222788	1137940	109227006
Thrombosis	136.83	23.46	27	224326	108635	110256311
Acute myocardial infarction	134.57	23.46	9	224344	83768	110281178
Herpes zoster	134.25	23.46	28	224325	108351	110256595
Influenza like illness	132.31	23.46	13	224340	88399	110276547
Hepatic function abnormal	131.37	23.46	14	224339	89281	110275665
Neuropathy peripheral	130.91	23.46	103	224250	179174	110185772
Wrong technique in product usage process	130.30	23.46	13	224340	87335	110277611
Blood pressure decreased	130.27	23.46	36	224317	115055	110249891
Leukopenia	126.78	23.46	72	224281	148719	110216227
Cardiac disorder	126.13	23.46	7	224346	76273	110288673
Dyspnoea exertional	124.61	23.46	29	224324	104031	110260915
Dysarthria	124.24	23.46	13	224340	84108	110280838
Coeliac disease	121.57	23.46	270	224083	42917	110322029
Blood pressure fluctuation	120.30	23.46	8	224345	74816	110290130
Adverse reaction	118.09	23.46	214	224139	29380	110335566
Cellulitis	117.78	23.46	54	224299	125962	110238984
International normalised ratio increased	117.05	23.46	18	224335	86754	110278192
Overdose	116.26	23.46	184	224169	233610	110131336
Vertigo	114.97	23.46	19	224334	86851	110278095
Angioedema	114.92	23.46	29	224324	98471	110266475
Amnesia	114.90	23.46	471	223882	104937	110260009
Swelling face	114.04	23.46	24	224329	92297	110272649
Cholestasis	112.97	23.46	4	224349	64514	110300432
Hallucination	112.44	23.46	33	224320	101399	110263547
Aspartate aminotransferase increased	111.67	23.46	96	224257	159840	110205106
Memory impairment	111.60	23.46	733	223620	196211	110168735
Dysphonia	111.46	23.46	12	224341	75917	110289029
Neutrophil count decreased	111.22	23.46	53	224300	120888	110244058
Haemoptysis	110.80	23.46	9	224344	71345	110293601
Sedation	110.43	23.46	8	224345	69675	110295271
C-reactive protein increased	110.39	23.46	789	223564	217130	110147816
Blood pressure systolic increased	110.17	23.46	18	224335	82973	110281973
Skin exfoliation	109.90	23.46	22	224331	87629	110277317
Knee arthroplasty	109.46	23.46	335	224018	64613	110300333
Treatment failure	109.18	23.46	947	223406	276287	110088659
Coronary artery disease	108.71	23.46	10	224343	71680	110293266
Illness	108.69	23.46	18	224335	82153	110282793
Blood creatine phosphokinase increased	108.68	23.46	11	224342	73066	110291880
Intentional product misuse	108.04	23.46	68	224285	132836	110232110
Haematuria	107.99	23.46	19	224334	82986	110281960
Grip strength	107.98	23.46	112	224241	9029	110355917
Ascites	106.98	23.46	28	224325	92780	110272166
Liver function test increased	106.45	23.46	408	223945	88140	110276806
Drug ineffective for unapproved indication	105.98	23.46	38	224315	102800	110262146
Back pain	103.92	23.46	394	223959	370602	109994344
Cataract	103.83	23.46	18	224335	79467	110285479
Walking aid user	103.47	23.46	184	224169	24891	110340055
Hepatic cirrhosis	103.14	23.46	337	224016	67289	110297657
Hypoxia	102.92	23.46	68	224285	129447	110235499
Lethargy	102.72	23.46	31	224322	93545	110271401
Chronic kidney disease	102.51	23.46	16	224337	76275	110288671
Disorientation	101.64	23.46	12	224341	70659	110294287
Hypothyroidism	100.93	23.46	14	224339	72885	110292061
Drug reaction with eosinophilia and systemic symptoms	100.06	23.46	22	224331	82073	110282873
Burkholderia test positive	99.39	23.46	40	224313	584	110364362
Disease recurrence	99.21	23.46	6	224347	60778	110304168
Paraesthesia	98.88	23.46	925	223428	275596	110089350
Pneumonia aspiration	98.54	23.46	22	224331	81211	110283735
Colitis	98.53	23.46	42	224311	102281	110262665
Orthostatic hypotension	98.45	23.46	10	224343	66239	110298707
Urinary retention	97.38	23.46	13	224340	69670	110295276
Weight decreased	96.31	23.46	556	223797	467501	109897445
Dry skin	96.23	23.46	49	224304	107604	110257342
Disturbance in attention	95.76	23.46	8	224345	61987	110302959
Muscle spasms	95.75	23.46	923	223430	277234	110087712
Melaena	95.67	23.46	13	224340	68744	110296202
Injection site swelling	95.37	23.46	8	224345	61782	110303164
Agranulocytosis	95.31	23.46	8	224345	61752	110303194
Transient ischaemic attack	94.20	23.46	10	224343	63972	110300974
Generalised tonic-clonic seizure	93.67	23.46	4	224349	54676	110310270
Product quality issue	93.60	23.46	357	223996	76942	110288004
Hyperglycaemia	91.94	23.46	29	224324	85061	110279885
Epilepsy	91.81	23.46	425	223928	99784	110265162
Hepatic cytolysis	91.18	23.46	5	224348	55048	110309898
Hepatic failure	91.04	23.46	15	224338	68724	110296222
Arthralgia	90.58	23.46	2144	222209	777488	109587458
Jaundice	90.53	23.46	8	224345	59228	110305718
Burkholderia infection	90.43	23.46	25	224328	98	110364848
Arrhythmia	90.35	23.46	16	224337	69559	110295387
Pancreatitis acute	89.83	23.46	9	224344	60265	110304681
Heart rate decreased	89.78	23.46	28	224325	82728	110282218
Swollen joint count	89.62	23.46	99	224254	8575	110356371
Angina pectoris	88.55	23.46	11	224342	62284	110302662
Bronchitis	87.51	23.46	114	224239	156918	110208028
Hypokalaemia	87.50	23.46	147	224206	182301	110182645
Body temperature increased	87.38	23.46	277	224076	54436	110310510
Renal disorder	86.87	23.46	3	224350	49476	110315470
Nephrolithiasis	86.47	23.46	15	224338	66197	110298749
Haematocrit decreased	86.30	23.46	15	224338	66102	110298844
Medication error	85.81	23.46	432	223921	104934	110260012
Burning sensation	85.47	23.46	18	224335	69194	110295752
Restlessness	84.90	23.46	8	224345	56251	110308695
Speech disorder	84.82	23.46	12	224341	61557	110303389
Intestinal obstruction	84.66	23.46	6	224347	53221	110311725
Pneumonitis	84.64	23.46	25	224328	76506	110288440
Flushing	84.56	23.46	54	224299	104682	110260264
Dyskinesia	84.20	23.46	5	224348	51441	110313505
Toxic epidermal necrolysis	83.17	23.46	9	224344	56718	110308228
Liver function test abnormal	82.98	23.46	19	224334	68931	110296015
Throat irritation	82.47	23.46	7	224346	53545	110311401
Haemorrhage	82.12	23.46	58	224295	106634	110258312
Haematoma	81.50	23.46	11	224342	58465	110306481
Rash erythematous	81.37	23.46	32	224321	81800	110283146
Respiratory arrest	81.17	23.46	11	224342	58288	110306658
Obstructive airways disorder	80.32	23.46	3	224350	46146	110318800
Unresponsive to stimuli	79.99	23.46	16	224337	63774	110301172
Blood urea increased	79.86	23.46	9	224344	54948	110309998
Foot deformity	79.77	23.46	248	224105	48232	110316714
Diverticulitis	79.74	23.46	8	224345	53514	110311432
Red blood cell count decreased	79.67	23.46	18	224335	65905	110299041
Full blood count abnormal	79.43	23.46	10	224343	56042	110308904
Tinnitus	78.44	23.46	14	224339	60526	110304420
Bone pain	78.28	23.46	18	224335	65115	110299831
Product contamination microbial	77.89	23.46	40	224313	1054	110363892
Aphasia	77.85	23.46	13	224340	58984	110305962
Drug resistance	77.63	23.46	11	224342	56363	110308583
Psychotic disorder	77.51	23.46	7	224346	50930	110314016
Hepatotoxicity	77.25	23.46	17	224336	63383	110301563
Mental status changes	76.96	23.46	29	224324	76093	110288853
Cerebral infarction	76.58	23.46	8	224345	51830	110313116
Delirium	76.13	23.46	502	223851	134523	110230423
Swollen tongue	75.99	23.46	15	224338	60347	110304599
Pallor	75.51	23.46	12	224341	56455	110308491
Transaminases increased	75.23	23.46	18	224335	63372	110301574
Blood bilirubin increased	75.06	23.46	30	224323	75942	110289004
Pericardial effusion	74.64	23.46	13	224340	57204	110307742
Viral infection	74.05	23.46	10	224343	53129	110311817
Eczema	74.00	23.46	27	224326	72266	110292680
Joint dislocation	73.90	23.46	193	224160	33997	110330949
Haematemesis	73.76	23.46	15	224338	59093	110305853
Multiple sclerosis relapse	73.58	23.46	8	224345	50232	110314714
Cholelithiasis	73.35	23.46	19	224334	63403	110301543
Product prescribing error	73.12	23.46	9	224344	51322	110313624
Rash maculo-papular	72.21	23.46	30	224323	74192	110290754
Pulmonary oedema	72	23.46	59	224294	100600	110264346
Mucosal inflammation	71.74	23.46	54	224299	96087	110268859
Neoplasm progression	71.62	23.46	21	224332	64574	110300372
Normal newborn	70.98	23.46	145	224208	21751	110343195
Injection site pruritus	70.59	23.46	10	224343	51248	110313698
Lymphocyte count decreased	70.45	23.46	15	224338	57228	110307718
Cerebral haemorrhage	70.44	23.46	22	224331	64946	110300000
Pneumocystis jirovecii pneumonia	70.41	23.46	4	224349	42731	110322215
Lymphadenopathy	70.33	23.46	21	224332	63814	110301132
Therapy interrupted	70.33	23.46	9	224344	49813	110315133
Dysgeusia	70.19	23.46	27	224326	69958	110294988
Tubulointerstitial nephritis	69.37	23.46	13	224340	54271	110310675
Encephalopathy	69.35	23.46	39	224314	81016	110283930
Incorrect route of product administration	68.81	23.46	285	224068	63776	110301170
Plasma cell myeloma	68.80	23.46	21	224332	62915	110302031
Ventricular tachycardia	68.30	23.46	10	224343	49999	110314947
Underdose	67.68	23.46	282	224071	63272	110301674
Hypocalcaemia	67.61	23.46	24	224329	65342	110299604
Hallucination, visual	67.50	23.46	3	224350	39602	110325344
Subcutaneous drug absorption impaired	66.65	23.46	80	224273	7579	110357367
Drug hypersensitivity	66.55	23.46	1292	223061	452798	109912148
Gastritis	66.24	23.46	14	224339	53685	110311261
Unevaluable event	66.14	23.46	19	224334	59208	110305738
Therapy non-responder	65.92	23.46	545	223808	156762	110208184
Red blood cell sedimentation rate increased	65.85	23.46	324	224029	77978	110286968
Diplopia	65.84	23.46	5	224348	41889	110323057
Bone marrow failure	65.63	23.46	18	224335	57830	110307116
Cystitis	65.37	23.46	26	224327	66010	110298936
Femur fracture	65.34	23.46	7	224346	44462	110320484
Proteinuria	65.16	23.46	4	224349	40014	110324932
Accidental overdose	65.00	23.46	13	224340	51821	110313125
Blood potassium decreased	64.95	23.46	15	224338	54099	110310847
Drug withdrawal syndrome	64.47	23.46	3	224350	38051	110326895
Aggression	64.29	23.46	20	224333	59190	110305756
Hemiparesis	64.28	23.46	7	224346	43896	110321050
Ear infection	64.20	23.46	275	224078	62457	110302489
Seronegative arthritis	64.03	23.46	104	224249	13073	110351873
Upper gastrointestinal haemorrhage	64.01	23.46	12	224341	50084	110314862
Dry eye	63.98	23.46	17	224336	55776	110309170
Recalled product administered	63.84	23.46	37	224316	1245	110363701
Therapy cessation	63.57	23.46	8	224345	44849	110320097
Oral candidiasis	63.39	23.46	8	224345	44752	110320194
Abnormal behaviour	63.27	23.46	4	224349	39035	110325911
Acute respiratory failure	63.27	23.46	37	224316	75223	110289723
Fungal infection	63.17	23.46	13	224340	50793	110314153
Cardiogenic shock	62.92	23.46	19	224334	57319	110307627
Gastroenteritis	62.81	23.46	4	224349	38796	110326150
Eosinophilia	62.14	23.46	20	224333	57916	110307030
Cytomegalovirus infection	61.66	23.46	17	224336	54427	110310519
Palmar-plantar erythrodysaesthesia syndrome	61.46	23.46	6	224347	41019	110323927
Acute hepatic failure	61.38	23.46	3	224350	36465	110328481
Tachycardia	61.30	23.46	244	224109	226401	110138545
Limb discomfort	61.14	23.46	6	224347	40848	110324098
Pulmonary hypertension	61.13	23.46	18	224335	55202	110309744
Metastases to liver	59.27	23.46	3	224350	35383	110329563
Overlap syndrome	59.02	23.46	82	224271	8977	110355969
Bacterial infection	58.88	23.46	11	224342	46025	110318921
Shock	58.36	23.46	18	224335	53570	110311376
Sleep apnoea syndrome	57.84	23.46	7	224346	40440	110324506
Hepatic steatosis	57.69	23.46	14	224339	48817	110316129
Urinary incontinence	57.26	23.46	14	224339	48573	110316373
Ventricular fibrillation	57.03	23.46	8	224345	41305	110323641
Joint injury	57.00	23.46	7	224346	39987	110324959
Ischaemic stroke	56.94	23.46	8	224345	41255	110323691
Neuroleptic malignant syndrome	56.70	23.46	3	224350	34056	110330890
Gastric ulcer	56.69	23.46	7	224346	39820	110325126
Nervousness	56.25	23.46	5	224348	36846	110328100
Hot flush	56.17	23.46	32	224321	66004	110298942
Acute respiratory distress syndrome	55.94	23.46	19	224334	53179	110311767
Subdural haematoma	55.50	23.46	5	224348	36449	110328497
Hepatic enzyme	55.21	23.46	60	224293	5103	110359843
Blood potassium increased	55.12	23.46	3	224350	33246	110331700
Dysstasia	54.61	23.46	3	224350	32983	110331963
Dysuria	54.45	23.46	27	224326	60204	110304742
Vasculitis	54.40	23.46	5	224348	35868	110329078
Procedural pain	53.81	23.46	5	224348	35560	110329386
Tachypnoea	53.52	23.46	8	224345	39387	110325559
Lung neoplasm malignant	53.29	23.46	4	224349	33838	110331108
Mental disorder	52.42	23.46	8	224345	38783	110326163
Myelodysplastic syndrome	52.36	23.46	7	224346	37477	110327469
Neutrophil count increased	52.09	23.46	5	224348	34647	110330299
Abdominal pain lower	51.99	23.46	7	224346	37276	110327670
Iron deficiency anaemia	51.85	23.46	3	224350	31556	110333390
Eye swelling	51.78	23.46	4	224349	33044	110331902
Blood sodium decreased	51.56	23.46	8	224345	38311	110326635
Head injury	51.47	23.46	12	224341	43005	110321941
Skin disorder	51.29	23.46	12	224341	42901	110322045
Stevens-Johnson syndrome	50.64	23.46	16	224337	46885	110318061
Posterior reversible encephalopathy syndrome	50.60	23.46	5	224348	33856	110331090
Exposure during pregnancy	50.58	23.46	541	223812	166883	110198063
Respiratory tract congestion	50.49	23.46	3	224350	30854	110334092
Nightmare	50.32	23.46	9	224344	38854	110326092
Limb injury	50.32	23.46	8	224345	37628	110327318
Blindness	50.29	23.46	7	224346	36352	110328594
Full blood count decreased	49.97	23.46	4	224349	32095	110332851
Throat tightness	49.90	23.46	5	224348	33484	110331462
Sinus congestion	49.73	23.46	3	224350	30456	110334490
Pollakiuria	49.67	23.46	14	224339	44181	110320765
Device issue	49.33	23.46	6	224347	34529	110330417
Status epilepticus	48.96	23.46	4	224349	31567	110333379
Myocarditis	48.95	23.46	3	224350	30052	110334894
Disseminated intravascular coagulation	48.45	23.46	12	224341	41274	110323672
Surgery	48.45	23.46	12	224341	41271	110323675
Gout	48.38	23.46	8	224345	36558	110328388
Cyanosis	48.34	23.46	3	224350	29738	110335208
Ejection fraction decreased	47.75	23.46	12	224341	40868	110324078
Paraesthesia oral	47.72	23.46	6	224347	33665	110331281
Localised infection	47.71	23.46	14	224339	43034	110321912
Eye pain	47.54	23.46	21	224332	50078	110314868
Oral herpes	47.50	23.46	8	224345	36072	110328874
Leukocytosis	47.36	23.46	25	224328	53803	110311143
Candida infection	47.36	23.46	19	224334	47990	110316956
Thrombotic microangiopathy	47.20	23.46	3	224350	29146	110335800
Sneezing	47.08	23.46	5	224348	31979	110332967
Hyperlipidaemia	47.08	23.46	8	224345	35840	110329106
Depressed mood	46.87	23.46	33	224320	60776	110304170
Extrapyramidal disorder	46.66	23.46	3	224350	28864	110336082
Injection site reaction	46.52	23.46	325	224028	88745	110276201
Ulcer haemorrhage	46.34	23.46	125	224228	22446	110342500
Eye pruritus	46.07	23.46	6	224347	32769	110332177
Rib fracture	45.55	23.46	7	224346	33763	110331183
Abdominal pain	45.54	23.46	749	223604	512240	109852706
Blood alkaline phosphatase increased	45.46	23.46	46	224307	70889	110294057
Product administration error	45.30	23.46	10	224343	37207	110327739
Neoplasm malignant	45.17	23.46	10	224343	37133	110327813
Acne	45.10	23.46	7	224346	33513	110331433
Ocular hyperaemia	44.99	23.46	12	224341	39274	110325672
Eating disorder	44.97	23.46	5	224348	30853	110334093
Hypomagnesaemia	44.92	23.46	34	224319	60336	110304610
Treatment noncompliance	44.91	23.46	49	224304	72941	110292005
Flatulence	44.74	23.46	25	224328	52124	110312822
Labelled drug-drug interaction medication error	44.66	23.46	4	224349	29298	110335648
Drug tolerance decreased	44.49	23.46	140	224213	27400	110337546
Mouth ulceration	44.40	23.46	21	224332	48117	110316829
Accidental exposure to product	44.33	23.46	23	224330	49985	110314961
Drug eruption	44.23	23.46	27	224326	53632	110311314
Hypophagia	44.05	23.46	26	224327	52600	110312346
Nephropathy toxic	43.98	23.46	3	224350	27475	110337471
Lip swelling	43.89	23.46	24	224329	50643	110314303
Irritability	43.87	23.46	21	224332	47788	110317158
Sinus disorder	43.66	23.46	7	224346	32721	110332225
Hypertension	43.45	23.46	1348	223005	508736	109856210
Adverse drug reaction	43.30	23.46	364	223989	105195	110259751
Clostridium difficile infection	43.29	23.46	26	224327	52103	110312843
Gastroenteritis viral	43.21	23.46	6	224347	31220	110333726
Appendicitis	43.07	23.46	4	224349	28460	110336486
Product use issue	42.98	23.46	879	223474	310816	110054130
Spondylitis	42.73	23.46	80	224273	11258	110353688
Therapeutic response shortened	42.60	23.46	5	224348	29578	110335368
Presyncope	42.58	23.46	23	224330	48864	110316082
Gamma-glutamyltransferase increased	42.54	23.46	37	224316	61272	110303674
Sinus bradycardia	42.41	23.46	5	224348	29478	110335468
Polyneuropathy	42.36	23.46	7	224346	32005	110332941
Epistaxis	42.19	23.46	130	224223	130242	110234704
Drug-induced liver injury	42.04	23.46	400	223953	119667	110245279
Disability	42	23.46	146	224207	30077	110334869
Dizziness	41.92	23.46	1087	223266	697106	109667840
Blood albumin decreased	41.54	23.46	4	224349	27648	110337298
Hepatitis	41.54	23.46	319	224034	89735	110275211
Eye disorder	41.34	23.46	5	224348	28901	110336045
Skin lesion	41.15	23.46	27	224326	51604	110313342
Blood pressure diastolic decreased	41.02	23.46	11	224342	35874	110329072
Blood calcium decreased	40.95	23.46	11	224342	35834	110329112
General symptom	40.54	23.46	68	224285	8778	110356168
Mitral valve incompetence	40.47	23.46	9	224344	33320	110331626
Pulmonary congestion	40.47	23.46	7	224346	30959	110333987
Crying	40.44	23.46	3	224350	25625	110339321
Aspergillus infection	40.42	23.46	3	224350	25613	110339333
Photosensitivity reaction	40.37	23.46	3	224350	25586	110339360
Rash macular	40.36	23.46	14	224339	38672	110326274
Hepatic encephalopathy	40.13	23.46	5	224348	28251	110336695
Hypoacusis	39.83	23.46	11	224342	35180	110329766
Hypersomnia	39.77	23.46	5	224348	28056	110336890
Hip fracture	39.76	23.46	11	224342	35140	110329806
Myocardial ischaemia	39.72	23.46	4	224349	26680	110338266
Pseudomonas infection	39.39	23.46	5	224348	27848	110337098
Asthma	39.31	23.46	720	223633	249571	110115375
Impaired work ability	39.22	23.46	4	224349	26415	110338531
Coagulopathy	39.05	23.46	17	224336	40894	110324052
Ataxia	38.92	23.46	7	224346	30101	110334845
Restless legs syndrome	38.53	23.46	3	224350	24623	110340323
Troponin increased	38.31	23.46	7	224346	29759	110335187
Subarachnoid haemorrhage	38.19	23.46	7	224346	29695	110335251
Tumour lysis syndrome	38.05	23.46	8	224345	30793	110334153
Ileus	37.92	23.46	8	224345	30721	110334225
Blood urine present	37.80	23.46	3	224350	24242	110340704
Mechanical ventilation complication	37.73	23.46	22	224331	749	110364197
Cardiac failure acute	37.48	23.46	3	224350	24075	110340871
Haemophagocytic lymphohistiocytosis	37.37	23.46	9	224344	31550	110333396
Pulmonary arterial hypertension	37.20	23.46	10	224343	32558	110332388
Blood triglycerides increased	37.19	23.46	3	224350	23923	110341023
Vaginal haemorrhage	36.70	23.46	4	224349	25070	110339876
Gastric disorder	36.69	23.46	11	224342	33346	110331600
Glycosylated haemoglobin increased	36.61	23.46	3	224350	23616	110341330
Pain	36.59	23.46	2324	222029	952631	109412315
Neuralgia	36.46	23.46	27	224326	48451	110316495
Toxic skin eruption	36.44	23.46	6	224347	27509	110337437
Circulatory collapse	36.33	23.46	21	224332	42972	110321974
Recalled product	36.26	23.46	24	224329	1026	110363920
Skin haemorrhage	36.24	23.46	4	224349	24823	110340123
Blood test abnormal	36.14	23.46	7	224346	28547	110336399
Arteriosclerosis	36.13	23.46	4	224349	24763	110340183
Transplant rejection	35.75	23.46	4	224349	24563	110340383
Device dislocation	35.71	23.46	10	224343	31694	110333252
Metastases to lung	35.55	23.46	3	224350	23060	110341886
Multiple sclerosis	35.42	23.46	5	224348	25693	110339253
Haemorrhoids	35.38	23.46	14	224339	35658	110329288
Poor quality sleep	35.29	23.46	7	224346	28070	110336876
Rash vesicular	35.10	23.46	86	224267	14566	110350380
Eye irritation	35.08	23.46	12	224341	33440	110331506
Cardiovascular disorder	34.98	23.46	3	224350	22757	110342189
Clostridium difficile colitis	34.75	23.46	23	224330	43755	110321191
Carpal tunnel syndrome	34.69	23.46	3	224350	22607	110342339
Brain oedema	34.68	23.46	10	224343	31088	110333858
Hallucination, auditory	34.42	23.46	6	224347	26391	110338555
Therapeutic response unexpected	34.40	23.46	4	224349	23839	110341107
Basal cell carcinoma	34.32	23.46	25	224328	45245	110319701
Joint stiffness	34.32	23.46	244	224109	66999	110297947
Chronic sinusitis	34.29	23.46	5	224348	25079	110339867
Skin ulcer	33.64	23.46	48	224305	63597	110301349
Renal tubular necrosis	33.61	23.46	10	224343	30465	110334481
Hyperthyroidism	33.39	23.46	9	224344	29252	110335694
Small intestinal obstruction	33.02	23.46	12	224341	32201	110332745
Cytopenia	33.00	23.46	10	224343	30106	110334840
Visual acuity reduced	32.95	23.46	12	224341	32161	110332785
Glomerular filtration rate decreased	32.87	23.46	9	224344	28947	110335999
Atrial flutter	32.79	23.46	5	224348	24257	110340689
Blood uric acid increased	32.65	23.46	3	224350	21526	110343420
Intervertebral disc protrusion	32.60	23.46	8	224345	27690	110337256
End stage renal disease	32.54	23.46	3	224350	21470	110343476
Metastases to central nervous system	32.50	23.46	4	224349	22813	110342133
Ulcer	32.44	23.46	24	224329	43092	110321854
Skin discolouration	32.36	23.46	31	224322	49015	110315931
Mood altered	32.35	23.46	3	224350	21372	110343574
Conjunctivitis	32.32	23.46	14	224339	33778	110331168
Skin laceration	32.26	23.46	14	224339	33739	110331207
Nervous system disorder	32.21	23.46	12	224341	31709	110333237
Ventricular extrasystoles	32.17	23.46	4	224349	22637	110342309
Eosinophil count increased	31.76	23.46	3	224350	21055	110343891
Pustular psoriasis	31.68	23.46	79	224274	13526	110351420
Paranoia	31.68	23.46	4	224349	22370	110342576
Injection site rash	31.26	23.46	5	224348	23414	110341532
Staphylococcal infection	31.14	23.46	59	224294	69885	110295061
Impaired quality of life	31.08	23.46	11	224342	30006	110334940
Poor venous access	31.06	23.46	6	224347	24516	110340430
Cold sweat	31.04	23.46	4	224349	22027	110342919
Splenomegaly	31.02	23.46	6	224347	24492	110340454
Foot fracture	30.82	23.46	7	224346	25539	110339407
Post procedural complication	30.80	23.46	8	224345	26650	110338296
Anuria	30.74	23.46	6	224347	24335	110340611
Flank pain	30.73	23.46	5	224348	23125	110341821
Middle insomnia	30.71	23.46	3	224350	20499	110344447
Rash papular	30.61	23.46	9	224344	27630	110337316
Product substitution issue	30.61	23.46	5	224348	23056	110341890
Generalised oedema	30.53	23.46	12	224341	30692	110334254
Uveitis	30.45	23.46	4	224349	21706	110343240
Thirst	30.45	23.46	4	224349	21703	110343243
Cardiomyopathy	30.34	23.46	15	224338	33510	110331436
Secretion discharge	30.22	23.46	3	224350	20241	110344705
COVID-19 pneumonia	30.18	23.46	19	224334	37124	110327822
Arteriosclerosis coronary artery	30.07	23.46	7	224346	25111	110339835
Pharyngitis	30.03	23.46	7	224346	25091	110339855
Electrolyte imbalance	30.01	23.46	19	224334	37009	110327937
Respiratory distress	29.87	23.46	59	224294	68815	110296131
Torsade de pointes	29.77	23.46	5	224348	22595	110342351
Hyperthermia	29.64	23.46	4	224349	21268	110343678
Glaucoma	29.62	23.46	5	224348	22512	110342434
Cardiomegaly	29.61	23.46	11	224342	29119	110335827
Breast cancer	29.59	23.46	21	224332	38521	110326425
Sinus tachycardia	29.50	23.46	28	224325	44465	110320481
Gallbladder disorder	29.20	23.46	4	224349	21025	110343921
Petechiae	28.92	23.46	6	224347	23311	110341635
Motor dysfunction	28.82	23.46	7	224346	24399	110340547
Mania	28.77	23.46	4	224349	20792	110344154
Hypervolaemia	28.49	23.46	35	224318	49425	110315521
Coordination abnormal	28.34	23.46	8	224345	25220	110339726
Urticaria thermal	28.25	23.46	16	224337	515	110364431
Product storage error	28.20	23.46	5	224348	21723	110343223
Atelectasis	28.19	23.46	20	224333	36692	110328254
Rash pruritic	28.17	23.46	103	224250	97966	110266980
Haemodynamic instability	28.16	23.46	6	224347	22882	110342064
Acute generalised exanthematous pustulosis	28.09	23.46	5	224348	21659	110343287
Sleep disorder due to general medical condition, hypersomnia type	28.02	23.46	27	224326	1992	110362954
Spinal stenosis	27.99	23.46	3	224350	19053	110345893
Tricuspid valve incompetence	27.90	23.46	7	224346	23866	110341080
Cholecystitis	27.64	23.46	9	224344	25873	110339073
Lymphoma	27.62	23.46	4	224349	20167	110344779
Deafness	27.29	23.46	10	224343	26699	110338247
Product dose omission in error	27.27	23.46	7	224346	23505	110341441
Oliguria	27.25	23.46	3	224350	18654	110346292
Activated partial thromboplastin time prolonged	27.24	23.46	6	224347	22362	110342584
Ankle fracture	26.98	23.46	4	224349	19815	110345131
Osteopenia	26.96	23.46	6	224347	22203	110342743
Lower gastrointestinal haemorrhage	26.93	23.46	3	224350	18483	110346463
Intestinal perforation	26.79	23.46	5	224348	20939	110344007
Joint effusion	26.72	23.46	5	224348	20900	110344046
Fear	26.72	23.46	7	224346	23186	110341760
Cytomegalovirus infection reactivation	26.64	23.46	3	224350	18330	110346616
Adrenal insufficiency	26.59	23.46	28	224325	42362	110322584
Pyelonephritis	26.58	23.46	9	224344	25241	110339705
Skin burning sensation	26.29	23.46	6	224347	21819	110343127
Haemorrhage intracranial	26.16	23.46	13	224340	28956	110335990
Radiculopathy	26.10	23.46	4	224349	19332	110345614
Micturition urgency	26.07	23.46	4	224349	19316	110345630
Escherichia infection	25.93	23.46	8	224345	23808	110341138
Upper respiratory tract infection	25.90	23.46	158	224195	131170	110233776
Retching	25.84	23.46	7	224346	22675	110342271
Mental impairment	25.76	23.46	7	224346	22632	110342314
Weight fluctuation	25.75	23.46	101	224252	22044	110342902
Photophobia	25.75	23.46	10	224343	25761	110339185
Needle issue	25.72	23.46	3	224350	17837	110347109
Intentional dose omission	25.25	23.46	5	224348	20075	110344871
Encephalitis	25.19	23.46	4	224349	18835	110346111
Renal injury	24.96	23.46	4	224349	18709	110346237
Respiratory tract infection	24.92	23.46	69	224284	71548	110293398
Injection site warmth	24.92	23.46	3	224350	17402	110347544
Peritonitis	24.73	23.46	18	224335	32589	110332357
Vitamin D deficiency	24.67	23.46	4	224349	18548	110346398
Upper limb fracture	24.65	23.46	6	224347	20882	110344064
Bronchopulmonary aspergillosis	24.65	23.46	15	224338	29848	110335098
Anal incontinence	24.61	23.46	7	224346	21957	110342989
Iron deficiency	24.54	23.46	4	224349	18472	110346474
Squamous cell carcinoma	24.51	23.46	4	224349	18459	110346487
Hyperbilirubinaemia	24.50	23.46	16	224337	30655	110334291
Premature delivery	24.44	23.46	16	224337	30616	110334330
Right ventricular failure	24.43	23.46	11	224342	25943	110339003
Aspiration	24.29	23.46	16	224337	30517	110334429
Duodenal ulcer	24.25	23.46	5	224348	19509	110345437
Pyrexia	24.21	23.46	2126	222227	896139	109468807
Benign prostatic hyperplasia	24.10	23.46	4	224349	18230	110346716
Hiatus hernia	24.02	23.46	13	224340	27593	110337353
Musculoskeletal disorder	23.99	23.46	8	224345	22656	110342290
Renal cyst	23.98	23.46	4	224349	18168	110346778
Malignant melanoma	23.96	23.46	3	224350	16888	110348058
Spinal fracture	23.94	23.46	8	224345	22625	110342321
Lung infiltration	23.88	23.46	10	224343	24618	110340328
Bronchospasm	23.85	23.46	16	224337	30223	110334723
Rhinitis	23.79	23.46	8	224345	22537	110342409
Acidosis	23.77	23.46	8	224345	22523	110342423
Red blood cell sedimentation rate abnormal	23.69	23.46	10	224343	24499	110340447
Enteritis	23.61	23.46	5	224348	19151	110345795
Lacrimation increased	23.58	23.46	17	224336	30933	110334013
Malnutrition	23.51	23.46	13	224340	27266	110337680
Incontinence	23.49	23.46	3	224350	16632	110348314
Nodule	23.49	23.46	19	224334	32612	110332334
Large intestine perforation	23.48	23.46	3	224350	16626	110348320

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AB03	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment
ATC	A01AB53	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment
ATC	B05CA02	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives
ATC	D08AC02	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Biguanides and amidines
ATC	D08AC52	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Biguanides and amidines
ATC	D09AA12	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA05	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
ATC	S01AX09	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
ATC	S02AA09	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
ATC	S03AA04	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives
FDA PE	N0000008478	Decreased Cell Wall Integrity
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:33281	antimicrobial agent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D003358	Cosmetics
MeSH PA	D004202	Disinfectants
MeSH PA	D009067	Mouthwashes
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:64946	anti-HIV agent
CHEBI has role	CHEBI:86327	antifungal drug
CHEBI has role	CHEBI:35718	antifungal agent
CHEBI has role	CHEBI:51076	antifouling biocide

Related Drugs by ATC class:

A01AB Antiinfectives and antiseptics for local oral treatment 22 drugs

amphotericin B benzoxonium chloride cetylpyridinium chlortetracycline clotrimazole domiphen doxycycline hexetidine hydrogen peroxide mepartricin metronidazole miconazole show all 22 →

B05CA Antiinfectives 8 drugs

cetylpyridinium ethacridine mandelic acid neomycin nitrofurazone noxytiolin sulfamethizole taurolidine

D08AC Biguanides and amidines 4 drugs

dibrompropamidine hexamidine polihexanide propamidine

D09AA Medicated dressings with antiinfectives 11 drugs

aluminium chlorohydrate benzalkonium cetylpyridinium clioquinol framycetin fusidic acid iodoform nitrofurazone phenylmercuric nitrate povidone-iodine triclosan

R02AA Antiseptics 15 drugs

ambazone benzalkonium benzethonium cetrimonium cetylpyridinium chlorquinaldol dequalinium dichlorobenzyl alcohol euflavine hexamidine hexylresorcinol octenidine show all 15 →

S01AX Other antiinfectives 13 drugs

bibrocathol cethexonium dibrompropamidine hexamidine lotilaner nitrofurazone picloxydine polihexanide povidone-iodine propamidine resorcinol sodium borate show all 13 →

S02AA Antiinfectives 17 drugs

acetic acid aluminium acetotartrate boric acid cefmenoxime chloramphenicol ciprofloxacin clioquinol fosfomycin gentamicin hydrogen peroxide miconazole neomycin show all 17 →

S03AA Antiinfectives 7 drugs

chloramphenicol ciprofloxacin gentamicin hexamidine neomycin Polymyxin B tetracycline

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Gingivitis	indication	66383009	DOID:3087
Mouth Infection Prevention	indication
Denture stomatitis	off-label use	69254008	DOID:11875
Aphthous ulcer of mouth	off-label use	426965005	DOID:9663
Dental Plaque Prevention	off-label use
Periodontitis	contraindication	41565005	DOID:824
Open wound	contraindication	125643001
Front Tooth Fillings	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Topical antiseptic for surface wounds	Indication
Cattle	Metritis	Indication
Cattle	Vaginitis	Indication
Dogs	Topical antiseptic for surface wounds	Indication
Horses	Topical antiseptic for surface wounds	Indication
Horses	Metritis	Indication
Horses	Vaginitis	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Nolvasan Antiseptic Ointment	Zoetis Inc.	1
Nolvasan Cap-Tabs	Zoetis Inc.	1
Nolvasan Suspension	Zoetis Inc.	1
Privasan Antiseptic Ointment	First Priority Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.17	Basic
pKa2	10.57	Basic
pKa3	3.32	Basic
pKa4	2.72	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
2%;70% (10.5ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	April 3, 2006	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (26ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	May 3, 2005	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (3ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	Oct. 10, 2006	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%	CHLORHEXIDINE GLUCONATE	SAGE PRODS	N021669	April 25, 2005	OTC	CLOTH	TOPICAL	7935093	Oct. 2, 2027	FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
2%;70%	SOLUPREP S	SOLVENTUM	N208288	Aug. 8, 2018	OTC	SOLUTION	TOPICAL	Jan. 20, 2026	REVISIONS TO THE LABELING TO DESCRIBE MODIFIED FORMULATION BASED ON RESULTS OF STUDIES EM-05-014624 AND EM-05-014815

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
72 kDa type IV collagenase	Enzyme	P08253	MMP2_HUMAN	IC50	5.12	CHEMBL
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN	IC50	5.12	CHEMBL
Dual specificity protein kinase CLK2	Kinase	P49760	CLK2_HUMAN	IC50	5.04	CHEMBL
Solute carrier family 22 member 1	Transporter	O15245	S22A1_HUMAN	IC50	6.68	CHEMBL
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN	IC50	6.40	CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN	IC50	6.15	CHEMBL
Multidrug and toxin extrusion protein 2	Transporter	Q86VL8	S47A2_HUMAN	IC50	6.30	CHEMBL
Solute carrier family 22 member 3	Transporter	O75751	S22A3_HUMAN	IC50	6.39	CHEMBL
Synaptojanin-2	Enzyme	O15056	SYNJ2_HUMAN	IC50	5	CHEMBL
Trypanothione reductase	Enzyme		TYTR_TRYCR	Ki	5.70	CHEMBL
CAAX prenyl protease 2	Enzyme		RCE1_YEAST	AC50	5.24	CHEMBL

External reference:

ID	Source
D00858	KEGG_DRUG
3697-42-5	SECONDARY_CAS_RN
18472-51-0	SECONDARY_CAS_RN
20791	RXNORM
C0008196	UMLSCUI
CHEBI:3614	CHEBI
XC9	PDB_CHEM_ID
CHEMBL790	ChEMBL_ID
CHEMBL1484251	ChEMBL_ID
CHEMBL4297088	ChEMBL_ID
D002710	MESH_DESCRIPTOR_UI
DB00878	DRUGBANK_ID
14052	IUPHAR_LIGAND_ID
C010882	MESH_SUPPLEMENTAL_RECORD_UI
500	INN_ID
R4KO0DY52L	UNII
9552079	PUBCHEM_CID
4411	MMSL
6085	MMSL
003177	NDDF
003674	NDDF
003722	NDDF
003723	NDDF
108895000	SNOMEDCT_US
373568007	SNOMEDCT_US
96316004	SNOMEDCT_US
96317008	SNOMEDCT_US
96318003	SNOMEDCT_US
CHEMBL486819	ChEMBL_ID
56-95-1	SECONDARY_CAS_RN
4019393	VANDF
4019673	VANDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Chlorhexidine Gluconate 0.12% Oral Rinse	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0003	LIQUID	1.20 [iU]	BUCCAL	ANDA	18 sections
Bactoshield CHG	HUMAN OTC DRUG LABEL	1	0116-0038	SOLUTION	2 mg	TOPICAL	NDA	14 sections
Bactoshield CHG	HUMAN OTC DRUG LABEL	1	0116-0039	SOLUTION	2 mg	TOPICAL	NDA	14 sections
Bactoshield CHG	HUMAN OTC DRUG LABEL	1	0116-0039	SOLUTION	2 mg	TOPICAL	NDA	14 sections
Cardinal Health	HUMAN OTC DRUG LABEL	1	0116-0061	LIQUID	4 g	TOPICAL	NDA	13 sections
Chlorhexidine Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0101	LIQUID	0.12 mg	ORAL	ANDA	17 sections
Antiseptic Skin Cleanser	HUMAN OTC DRUG LABEL	1	0116-0137	LIQUID	4 mg	TOPICAL	NDA	14 sections
Antiseptic Skin Cleanser	HUMAN OTC DRUG LABEL	1	0116-0161	LIQUID	4 mg	TOPICAL	NDA	15 sections
Chlorhexidine Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0175	RINSE	1.20 mg	ORAL	ANDA	17 sections
BETASEPT	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0200	SOLUTION	0.04 mg	TOPICAL	NDA	14 sections
Chlorhexidine Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0301	RINSE	1.20 mg	ORAL	ANDA	19 sections
Antiseptic Skin Cleanser	HUMAN OTC DRUG LABEL	1	0116-0401	LIQUID	4 mg	TOPICAL	NDA	14 sections
ANTISEPTIC SKIN CLEANSER	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0407	SOLUTION	4 g	TOPICAL	NDA	15 sections
Antiseptic Skin Cleanser	HUMAN OTC DRUG LABEL	1	0116-0767	LIQUID	4 g	TOPICAL	NDA	14 sections
NUPRO Chlorhexidine Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0116-0800	RINSE	1.20 mg	ORAL	ANDA	20 sections
CliniClean	HUMAN OTC DRUG LABEL	1	0116-0901	SOLUTION	4 g	TOPICAL	NDA	14 sections
DYNA-HEX2	HUMAN OTC DRUG LABEL	1	0116-1021	LIQUID	2 g	TOPICAL	NDA	14 sections
DYNA-HEX2	HUMAN OTC DRUG LABEL	1	0116-1021	LIQUID	2 g	TOPICAL	NDA	14 sections
Dyna-Hex 2	HUMAN OTC DRUG LABEL	1	0116-1022	SOLUTION	20 mg	TOPICAL	NDA	14 sections
Dyna-Hex 2	HUMAN OTC DRUG LABEL	1	0116-1022	SOLUTION	20 mg	TOPICAL	NDA	14 sections
DYNA-HEX 4	HUMAN OTC DRUG LABEL	1	0116-1060	LIQUID	4 g	TOPICAL	NDA	15 sections
DYNA-HEX 4	HUMAN OTC DRUG LABEL	1	0116-1060	LIQUID	4 g	TOPICAL	NDA	15 sections
ANTISEPTIC SKIN CLEANSER	HUMAN OTC DRUG LABEL	1	0116-1061	SOLUTION	4 g	TOPICAL	NDA	13 sections
ANTISEPTIC SKIN CLEANSER	HUMAN OTC DRUG LABEL	1	0116-1061	SOLUTION	4 g	TOPICAL	NDA	13 sections
ANTISEPTIC SKIN CLEANSER	HUMAN OTC DRUG LABEL	1	0116-1061	SOLUTION	4 g	TOPICAL	NDA	13 sections
Foster and Thrive	HUMAN OTC DRUG LABEL	1	0116-1221	SOLUTION	4 g	TOPICAL	NDA	16 sections
Bactoshield CHG	HUMAN OTC DRUG LABEL	1	0116-1344	SOLUTION	40 mg	TOPICAL	NDA	15 sections
Chlorhexidine Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0116-2001	RINSE	1.20 mg	ORAL	ANDA	17 sections
Scrub CareExidine -4 CHG	HUMAN OTC DRUG LABEL	1	0116-2994	LIQUID	4 mg	TOPICAL	NDA	13 sections
Antiseptic Skin Cleanser	HUMAN OTC DRUG LABEL	1	0116-3678	LIQUID	4 mg	TOPICAL	NDA	15 sections