benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 3017 139-07-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzalkonium chloride
  • benzalkonium
  • benzyldodecyldimethylammonium chloride
  • benzododecinium
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA:
  • ALOGS: -7.85
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 55
kinase-selectivity-class AKT2,AKT3,AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,MTOR,PDK4,PLK1,PRKCD,SIK2,STK33,TEK 15
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5189.82 9.17 2851 111579 142207 90371810
Toxicity to various agents 3335.49 9.17 2814 111616 285032 90228985
Drug abuse 1881.30 9.17 1215 113215 81132 90432885
Cardio-respiratory arrest 1119.91 9.17 797 113633 62343 90451674
Local anaesthetic systemic toxicity 1025.29 9.17 313 114117 3187 90510830
Intentional overdose 702.95 9.17 722 113708 93112 90420905
Cardiac arrest 651.52 9.17 731 113699 104204 90409813
Overdose 514.64 9.17 801 113629 156908 90357109
Alcohol interaction 493.09 9.17 152 114278 1602 90512415
Suspected suicide 468.84 9.17 233 114197 9335 90504682
Suicide attempt 457.17 9.17 519 113911 74880 90439137
Exposure to toxic agent 375.58 9.17 189 114241 7778 90506239
Maternal exposure during delivery 362.66 9.17 148 114282 3698 90510319
Pemphigus 323.97 9.17 23 114407 326841 90187176
Respiratory arrest 310.33 9.17 289 114141 33022 90480995
Methaemoglobinaemia 309.94 9.17 134 114296 3881 90510136
Victim of crime 307.46 9.17 90 114340 782 90513235
Alcohol poisoning 301.15 9.17 107 114323 1805 90512212
Synovitis 297.82 9.17 34 114396 329718 90184299
Glossodynia 291.05 9.17 33 114397 321746 90192271
Hand deformity 284.81 9.17 24 114406 296338 90217679
Systemic lupus erythematosus 282.00 9.17 57 114373 361839 90152178
Death 263.92 9.17 1208 113222 455343 90058674
Anaphylactic shock 239.63 9.17 245 114185 31372 90482645
Pericarditis 238.60 9.17 30 114400 270121 90243896
Hepatic enzyme increased 231.78 9.17 83 114347 360653 90153364
Wound 221.35 9.17 55 114375 302925 90211092
Toxic anterior segment syndrome 220.44 9.17 89 114341 2161 90511856
Anti-cyclic citrullinated peptide antibody positive 216.90 9.17 23 114407 236410 90277607
Intentional product misuse 213.60 9.17 396 114034 89208 90424809
Substance use disorder 205.15 9.17 82 114348 1938 90512079
Alopecia 203.75 9.17 195 114235 494876 90019141
Duodenal ulcer perforation 199.26 9.17 23 114407 221265 90292752
Anaphylactic reaction 197.68 9.17 378 114052 87146 90426871
Generalised tonic-clonic seizure 194.25 9.17 230 114200 34673 90479344
Hypotension 188.50 9.17 862 113568 324535 90189482
Abdominal discomfort 187.25 9.17 196 114234 477132 90036885
Coma 181.96 9.17 328 114102 72304 90441713
Helicobacter infection 180.25 9.17 34 114396 226816 90287201
Joint swelling 178.65 9.17 224 114206 503076 90010941
Seizure 174.63 9.17 505 113925 152124 90361893
Drug use disorder 172.86 9.17 116 114314 8227 90505790
Rheumatoid factor positive 170.19 9.17 12 114418 171638 90342379
Mydriasis 165.00 9.17 143 114287 14869 90499148
Somnolence 164.57 9.17 609 113821 208475 90305542
Kounis syndrome 164.27 9.17 75 114355 2478 90511539
Folliculitis 163.69 9.17 30 114400 204323 90309694
Psoriatic arthropathy 161.85 9.17 44 114386 228291 90285726
General physical health deterioration 160.37 9.17 128 114302 354987 90159030
Contraindicated product administered 156.72 9.17 106 114324 320033 90193984
Alcohol use 154.83 9.17 64 114366 1653 90512364
Impaired healing 148.45 9.17 55 114375 234144 90279873
Poisoning deliberate 145.81 9.17 139 114291 16347 90497670
Muscle injury 145.72 9.17 24 114406 176630 90337387
Alcohol abuse 144.42 9.17 64 114366 1969 90512048
Rheumatic fever 142.72 9.17 14 114416 153107 90360910
Swelling 136.97 9.17 198 114232 418860 90095157
Chemical submission 132.53 9.17 42 114388 488 90513529
Mobility decreased 132.40 9.17 76 114354 250658 90263359
Agitation 131.32 9.17 273 114157 66825 90447192
Infusion site pain 128.34 9.17 141 114289 19597 90494420
Stress cardiomyopathy 124.61 9.17 116 114314 13239 90500778
Arthropathy 121.68 9.17 171 114259 366071 90147946
Drug intolerance 120.92 9.17 239 114191 447352 90066665
Gastrointestinal toxicity 120.17 9.17 98 114332 9369 90504648
Type 2 diabetes mellitus 118.64 9.17 54 114376 203190 90310827
Anaesthetic complication 117.71 9.17 59 114371 2406 90511611
Pulseless electrical activity 116.63 9.17 94 114336 8838 90505179
Sleep disorder due to general medical condition, insomnia type 114.27 9.17 14 114416 128680 90385337
Irritable bowel syndrome 110.77 9.17 62 114368 207386 90306631
Lower respiratory tract infection 109.81 9.17 93 114337 250566 90263451
Ill-defined disorder 109.68 9.17 48 114382 184843 90329174
Substance abuse 109.21 9.17 74 114356 5332 90508685
Infusion related reaction 107.09 9.17 229 114201 416551 90097466
Ventricular tachycardia 105.97 9.17 143 114287 24565 90489452
Hypersensitivity 105.43 9.17 264 114166 454413 90059604
Therapeutic product effect decreased 105.35 9.17 117 114313 277454 90236563
Poisoning 104.70 9.17 112 114318 15105 90498912
Blister 104.09 9.17 101 114329 254897 90259120
Infusion site swelling 102.10 9.17 98 114332 11622 90502395
Unresponsive to stimuli 101.69 9.17 177 114253 37944 90476073
Loss of consciousness 100.82 9.17 397 114033 139841 90374176
Tachycardia 100.45 9.17 430 114000 157243 90356774
Stomatitis 95.51 9.17 124 114306 274574 90239443
Swollen joint count increased 94.20 9.17 14 114416 111192 90402825
Pulmonary toxicity 92.19 9.17 92 114338 11439 90502578
Bradycardia 89.71 9.17 271 114159 83576 90430441
Rheumatoid arthritis 89.21 9.17 204 114226 362410 90151607
Insurance issue 88.67 9.17 88 114342 10870 90503147
Procedural hypotension 87.48 9.17 42 114388 1558 90512459
Sulphaemoglobinaemia 84.59 9.17 30 114400 503 90513514
Rash 84.31 9.17 624 113806 795476 89718541
Infusion site erythema 82.61 9.17 94 114336 13576 90500441
Lip dry 82.60 9.17 14 114416 100941 90413076
Drug interaction 82.13 9.17 614 113816 275839 90238178
Anaesthetic complication neurological 81.97 9.17 32 114398 709 90513308
Infusion site extravasation 81.83 9.17 82 114348 10246 90503771
Body tinea 81.32 9.17 44 114386 2104 90511913
Victim of sexual abuse 80.39 9.17 31 114399 664 90513353
Infusion site pruritus 79.56 9.17 67 114363 6698 90507319
Gait inability 77.83 9.17 44 114386 146412 90367605
Peripheral venous disease 77.33 9.17 8 114422 83913 90430104
Apnoea 76.91 9.17 76 114354 9338 90504679
Facet joint syndrome 75.49 9.17 16 114414 98373 90415644
Respiratory depression 74.32 9.17 95 114335 15480 90498537
Diarrhoea 74.03 9.17 794 113636 938396 89575621
Discomfort 73.56 9.17 147 114283 274188 90239829
Pulse absent 73.34 9.17 61 114369 5994 90508023
Electrocardiogram QRS complex prolonged 72.79 9.17 66 114364 7282 90506735
Sinus tachycardia 71.68 9.17 129 114301 28384 90485633
Blood alcohol increased 71.64 9.17 27 114403 542 90513475
Blood cholesterol increased 71.16 9.17 95 114335 207917 90306100
Arthralgia 69.73 9.17 638 113792 777884 89736133
Ventricular fibrillation 69.13 9.17 87 114343 13957 90500060
Abdominal pain upper 68.91 9.17 204 114226 332470 90181547
Mental status changes 68.55 9.17 165 114265 44514 90469503
Infusion site haemorrhage 66.56 9.17 55 114375 5356 90508661
Osteoarthritis 66.33 9.17 90 114340 195640 90318377
Product administration interrupted 65.69 9.17 80 114350 12412 90501605
Drug dependence 65.36 9.17 126 114304 29201 90484816
Fibromyalgia 64.83 9.17 100 114330 206169 90307848
Sleep disorder 64.18 9.17 94 114336 197936 90316081
Inhibitory drug interaction 63.19 9.17 43 114387 3120 90510897
Postmortem blood drug level abnormal 63.14 9.17 20 114410 232 90513785
Alcoholism 62.98 9.17 35 114395 1765 90512252
Nystagmus 62.14 9.17 60 114370 7167 90506850
Neoplasm malignant 60.68 9.17 133 114297 33747 90480270
Depressed level of consciousness 60.56 9.17 216 114214 72568 90441449
Phrenic nerve paralysis 60.53 9.17 21 114409 329 90513688
Prescribed underdose 60.07 9.17 11 114419 75008 90439009
Grip strength decreased 58.18 9.17 22 114408 92554 90421463
Victim of chemical submission 58.14 9.17 25 114405 714 90513303
Embolia cutis medicamentosa 58.09 9.17 24 114406 619 90513398
Inflammation 57.65 9.17 85 114345 178507 90335510
Pulmonary fibrosis 57.54 9.17 32 114398 107471 90406546
Systemic toxicity 57.32 9.17 19 114411 257 90513760
Tracheal deviation 57.32 9.17 19 114411 257 90513760
Obesity 57.06 9.17 31 114399 105476 90408541
Infusion site bruising 57.06 9.17 46 114384 4326 90509691
Infection susceptibility increased 57.03 9.17 44 114386 3882 90510135
Peripheral swelling 57.00 9.17 298 114132 412808 90101209
Asthenia 56.56 9.17 418 114012 533333 89980684
Electrocardiogram ST segment elevation 56.15 9.17 44 114386 3972 90510045
C-reactive protein increased 55.99 9.17 89 114341 181300 90332717
Corneal oedema 55.90 9.17 33 114397 1868 90512149
Cardiogenic shock 55.60 9.17 106 114324 24362 90489655
Withdrawal syndrome 55.46 9.17 101 114329 22423 90491594
Wheezing 55.28 9.17 138 114292 237942 90276075
Sinusitis 53.45 9.17 665 113765 342423 90171594
Breast cancer stage III 53.19 9.17 20 114410 84427 90429590
Joint injury 52.68 9.17 123 114307 32541 90481476
Wound infection 52.31 9.17 35 114395 106367 90407650
Suicidal ideation 52.18 9.17 208 114222 73647 90440370
Status epilepticus 52.12 9.17 89 114341 18785 90495232
Deep vein thrombosis postoperative 51.36 9.17 13 114417 70796 90443221
Night sweats 51.36 9.17 52 114378 128714 90385303
Extradural haematoma 50.81 9.17 32 114398 2036 90511981
Product use issue 50.70 9.17 229 114201 329690 90184327
Aggression 50.41 9.17 107 114323 26561 90487456
Electrocardiogram QT prolonged 50.34 9.17 203 114227 72253 90441764
Illness 50.21 9.17 221 114209 81748 90432269
Extradural abscess 50.17 9.17 27 114403 1277 90512740
Incorrect drug administration rate 49.95 9.17 46 114384 5177 90508840
Gastrointestinal disorder 49.88 9.17 162 114268 256525 90257492
Circulatory collapse 49.50 9.17 102 114328 24802 90489215
Incorrect route of product administration 48.94 9.17 158 114272 50468 90463549
Glucose tolerance impaired 48.40 9.17 55 114375 7930 90506087
Joint range of motion decreased 48.39 9.17 60 114370 135583 90378434
Weight increased 48.32 9.17 319 114111 417608 90096409
Bursitis 48.27 9.17 57 114373 131597 90382420
Dislocation of vertebra 47.50 9.17 7 114423 55961 90458056
Hypercholesterolaemia 47.21 9.17 35 114395 100857 90413160
Dermatitis contact 46.98 9.17 71 114359 13524 90500493
Lung disorder 46.77 9.17 73 114357 149810 90364207
Fear 45.40 9.17 78 114352 16544 90497473
Hepatotoxicity 45.16 9.17 144 114286 45698 90468319
Drug withdrawal syndrome 45.06 9.17 107 114323 28616 90485401
Vascular malformation 44.98 9.17 21 114409 731 90513286
Musculoskeletal stiffness 44.86 9.17 207 114223 296325 90217692
Product adhesion issue 44.79 9.17 43 114387 5099 90508918
COVID-19 44.56 9.17 365 114065 168478 90345539
Knee arthroplasty 44.17 9.17 25 114405 83157 90430860
Foetal exposure during delivery 44.13 9.17 17 114413 363 90513654
Red blood cell sedimentation rate increased 43.61 9.17 25 114405 82570 90431447
Paranasal cyst 43.49 9.17 21 114409 789 90513228
Infusion site urticaria 43.30 9.17 27 114403 1688 90512329
Hip arthroplasty 43.28 9.17 21 114409 76187 90437830
Therapy interrupted 42.79 9.17 150 114280 49958 90464059
X-ray abnormal 42.71 9.17 4 114426 45420 90468597
Hypoxia 42.69 9.17 193 114237 72206 90441811
Purtscher retinopathy 42.17 9.17 13 114417 137 90513880
Seasonal allergy 42.04 9.17 91 114339 22892 90491125
Pulmonary oedema 41.59 9.17 172 114258 61908 90452109
Thrombocytopenia 41.05 9.17 131 114299 208594 90305423
Poor quality sleep 40.93 9.17 94 114336 24599 90489418
Prescribed overdose 40.58 9.17 38 114392 97587 90416430
Areflexia 40.55 9.17 35 114395 3618 90510399
Drug level increased 39.90 9.17 100 114330 27662 90486355
Psoriasis 39.73 9.17 79 114351 147675 90366342
Brain stem syndrome 39.57 9.17 19 114411 705 90513312
Nail disorder 38.89 9.17 13 114417 59054 90454963
Liver injury 38.71 9.17 100 114330 170467 90343550
Blepharospasm 38.66 9.17 11 114419 55434 90458583
Onychomadesis 38.47 9.17 6 114424 45992 90468025
Liver disorder 37.89 9.17 59 114371 121210 90392807
Cyanosis 37.86 9.17 79 114351 19376 90494641
Emotional distress 37.80 9.17 117 114313 36545 90477472
Pain 37.78 9.17 964 113466 995377 89518640
Treatment failure 37.67 9.17 227 114203 303701 90210316
Condition aggravated 37.48 9.17 528 113902 595017 89919000
Dry mouth 37.26 9.17 114 114316 183945 90330072
Lagophthalmos 37.24 9.17 16 114414 456 90513561
Meningitis chemical 37.24 9.17 14 114416 279 90513738
Staphylococcal infection 37.13 9.17 140 114290 48299 90465718
Bronchospasm 36.75 9.17 81 114349 20628 90493389
Asphyxia 36.56 9.17 45 114385 7058 90506959
Anterior chamber cell 36.28 9.17 18 114412 718 90513299
Peripheral nerve injury 36.21 9.17 18 114412 721 90513296
Encephalopathy 35.40 9.17 134 114296 46310 90467707
Disease progression 35.40 9.17 92 114338 156523 90357494
Underdose 35.37 9.17 12 114418 54005 90460012
Pruritus 34.82 9.17 478 113952 541047 89972970
Neurotoxicity 34.79 9.17 81 114349 21386 90492631
Pneumocephalus 34.72 9.17 13 114417 256 90513761
Loss of personal independence in daily activities 34.71 9.17 75 114355 136030 90377987
Bundle branch block left 34.36 9.17 46 114384 7839 90506178
Bone erosion 34.33 9.17 12 114418 53009 90461008
Myocarditis 34.11 9.17 62 114368 13744 90500273
Restlessness 34.09 9.17 111 114319 35609 90478408
Adverse event 34.01 9.17 60 114370 117358 90396659
Neutropenia 34.00 9.17 157 114273 224747 90289270
Hypoaesthesia 33.74 9.17 245 114185 313965 90200052
Shock 33.62 9.17 96 114334 28682 90485335
Spinal epidural haemorrhage 33.30 9.17 13 114417 288 90513729
Administration site pain 33.29 9.17 20 114410 1169 90512848
Cauda equina syndrome 33.20 9.17 21 114409 1346 90512671
Type I hypersensitivity 32.94 9.17 33 114397 4122 90509895
Infusion site mass 32.82 9.17 25 114405 2164 90511853
Hypopyon 32.60 9.17 18 114412 896 90513121
Infusion site discharge 32.59 9.17 26 114404 2409 90511608
Amnesia 32.17 9.17 241 114189 108264 90405753
Removal of foreign body 31.73 9.17 7 114423 15 90514002
Hepatic encephalopathy 31.71 9.17 60 114370 13712 90500305
Fatigue 31.39 9.17 1167 113263 1152856 89361161
Endophthalmitis 31.38 9.17 34 114396 4651 90509366
Bursitis infective 31.29 9.17 21 114409 1489 90512528
Spinal epidural haematoma 31.17 9.17 20 114410 1314 90512703
Dyspepsia 30.75 9.17 137 114293 198023 90315994
Miosis 30.62 9.17 48 114382 9436 90504581
Paraplegia 30.61 9.17 29 114401 3383 90510634
Dysarthria 30.46 9.17 143 114287 54339 90459678
Nasopharyngitis 30.40 9.17 348 114082 406756 90107261
Respiratory tract infection 30.11 9.17 151 114279 58927 90455090
Confusional state 30.08 9.17 327 114103 385878 90128139
Decreased appetite 30.05 9.17 317 114113 376223 90137794
Infusion site rash 30.04 9.17 25 114405 2458 90511559
Accidental death 29.85 9.17 23 114407 2025 90511992
Mastoiditis 29.38 9.17 21 114409 1649 90512368
Stridor 29.03 9.17 33 114397 4760 90509257
Fear of eating 28.77 9.17 13 114417 419 90513598
Protein C increased 28.36 9.17 8 114422 60 90513957
Colitis ulcerative 28.07 9.17 21 114409 60245 90453772
Blood ethanol increased 27.99 9.17 9 114421 110 90513907
Postmortem blood drug level 27.99 9.17 9 114421 110 90513907
Gastrooesophageal reflux disease 27.65 9.17 112 114318 166225 90347792
Drug ineffective for unapproved indication 27.64 9.17 161 114269 66483 90447534
Frequent bowel movements 27.62 9.17 19 114411 56916 90457101
Platelet aggregation inhibition 27.59 9.17 10 114420 179 90513838
Respiratory acidosis 27.49 9.17 42 114388 8077 90505940
Disinhibition 27.43 9.17 17 114413 1051 90512966
Corneal epithelium defect 27.18 9.17 13 114417 478 90513539
Haemodynamic instability 26.85 9.17 51 114379 11688 90502329
Liver function test increased 26.78 9.17 41 114389 84814 90429203
Hyperthermia malignant 26.77 9.17 18 114412 1280 90512737
Somnambulism 26.63 9.17 36 114394 6192 90507825
Drug ineffective 26.41 9.17 1455 112975 1382843 89131174
Lupus vulgaris 26.23 9.17 12 114418 45047 90468970
Accidental overdose 26.21 9.17 87 114343 28186 90485831
Ventricular hypokinesia 26.15 9.17 33 114397 5308 90508709
Retinitis 26.14 9.17 8 114422 38450 90475567
Epidural haemorrhage 25.95 9.17 11 114419 303 90513714
Anal skin tags 25.94 9.17 14 114416 666 90513351
Parophthalmia 25.88 9.17 12 114418 411 90513606
Neonatal toxicity 25.75 9.17 7 114423 45 90513972
Congestive hepatopathy 25.74 9.17 25 114405 3008 90511009
Altered state of consciousness 25.73 9.17 93 114337 31439 90482578
Anxiety 25.72 9.17 541 113889 309231 90204786
Premature delivery 25.65 9.17 107 114323 38655 90475362
Vitritis 25.46 9.17 19 114411 1595 90512422
Urinary tract infection 25.45 9.17 534 113896 305098 90208919
Hyperlipidaemia 25.38 9.17 75 114355 22841 90491176
Anhedonia 25.33 9.17 49 114381 11382 90502635
Renal injury 25.31 9.17 46 114384 10197 90503820
Impaired work ability 25.08 9.17 67 114363 19259 90494758
Upper respiratory tract infection 25.03 9.17 260 114170 128058 90385959
Schizencephaly 25.02 9.17 11 114419 332 90513685
Cerebral haemorrhage foetal 24.86 9.17 11 114419 337 90513680
Back injury 24.77 9.17 14 114416 46608 90467409
Off label use 24.76 9.17 1139 113291 1101113 89412904
Breast cancer stage II 24.66 9.17 7 114423 35327 90478690
Vocal cord dysfunction 24.63 9.17 15 114415 899 90513118
Bone density decreased 24.43 9.17 62 114368 17283 90496734
Infusion site nodule 24.35 9.17 19 114411 1704 90512313
Brain oedema 24.33 9.17 62 114368 17323 90496694
Therapy partial responder 24.28 9.17 72 114358 21971 90492046
C-reactive protein 24.26 9.17 5 114425 31362 90482655
Metabolic acidosis 24.07 9.17 136 114294 55540 90458477
Substance dependence 23.96 9.17 9 114421 179 90513838
Drug hypersensitivity 23.78 9.17 427 114003 463182 90050835
Surgery 23.78 9.17 116 114314 44771 90469246
Blood lactic acid increased 23.72 9.17 41 114389 8737 90505280
Otitis media 23.70 9.17 33 114397 5837 90508180
Aqueous fibrin 23.69 9.17 8 114422 115 90513902
Arthritis 23.42 9.17 120 114310 167195 90346822
Central pain syndrome 23.37 9.17 13 114417 657 90513360
Brain death 23.20 9.17 27 114403 3994 90510023
Impaired quality of life 23.06 9.17 73 114357 23071 90490946
Malaise 22.93 9.17 564 113866 585422 89928595
Coeliac disease 22.84 9.17 14 114416 44596 90469421
Trigeminal palsy 22.60 9.17 7 114423 75 90513942
Homicide 22.52 9.17 10 114420 309 90513708
Kidney infection 22.49 9.17 78 114352 25838 90488179
Drug reaction with eosinophilia and systemic symptoms 22.49 9.17 13 114417 42745 90471272
Septic arthritis staphylococcal 22.35 9.17 12 114418 565 90513452
Medical device site cellulitis 22.35 9.17 9 114421 217 90513800
Administration site swelling 22.21 9.17 17 114413 1482 90512535
Cardiac death 22.14 9.17 12 114418 576 90513441
Ophthalmoplegia 21.98 9.17 18 114412 1731 90512286
Spinal anaesthesia 21.96 9.17 7 114423 83 90513934
Alcohol withdrawal syndrome 21.96 9.17 14 114416 910 90513107
Sciatica 21.81 9.17 61 114369 101321 90412696
Retinal vasculitis 21.80 9.17 17 114413 1524 90512493
Eyelid ptosis 21.69 9.17 40 114390 8966 90505051
Haematochezia 21.67 9.17 35 114395 70878 90443139
Urticaria 21.55 9.17 272 114158 312462 90201555
Lower limb fracture 21.54 9.17 47 114383 84966 90429051
Meningitis aseptic 21.48 9.17 34 114396 6739 90507278
Infusion site discomfort 21.38 9.17 18 114412 1798 90512219
Drug screen positive 21.30 9.17 25 114405 3732 90510285
Alcoholic 21.22 9.17 5 114425 16 90514001
Unevaluable event 21.14 9.17 130 114300 54718 90459299
Epidural analgesia 21.12 9.17 8 114422 163 90513854
Malignant neoplasm progression 21.05 9.17 67 114363 106803 90407214
Gait disturbance 20.89 9.17 219 114211 260277 90253740
Procedure aborted 20.89 9.17 8 114422 168 90513849
Serotonin syndrome 20.85 9.17 99 114331 37788 90476229
Upper airway obstruction 20.55 9.17 14 114416 1018 90512999
Electrocardiogram ST segment depression 20.44 9.17 23 114407 3280 90510737
Spinal cord compression 20.41 9.17 28 114402 4883 90509134
Pyrexia 20.40 9.17 657 113773 659828 89854189
Psychomotor hyperactivity 20.39 9.17 48 114382 12765 90501252
Orthostatic hypotension 20.23 9.17 14 114416 41813 90472204
Onychomycosis 20.18 9.17 11 114419 37365 90476652
Retrograde amnesia 20.01 9.17 11 114419 543 90513474
Purpura 19.96 9.17 52 114378 14726 90499291
Vasoplegia syndrome 19.87 9.17 21 114409 2793 90511224
Blood ethanol 19.79 9.17 5 114425 23 90513994
Induced abortion failed 19.71 9.17 8 114422 197 90513820
Intentional dose omission 19.50 9.17 58 114372 17725 90496292
Medical device site abscess 19.48 9.17 8 114422 203 90513814
Renal tubular necrosis 19.44 9.17 51 114379 14504 90499513
Ventricular extrasystoles 19.33 9.17 48 114382 13202 90500815
Adjustment disorder with depressed mood 19.31 9.17 26 114404 56727 90457290
Amphetamines positive 19.30 9.17 8 114422 208 90513809
Infusion site irritation 19.30 9.17 15 114415 1338 90512679
Blood pressure decreased 19.26 9.17 161 114269 74734 90439283
Dyspnoea 19.21 9.17 913 113517 880042 89633975
Opiates positive 19.18 9.17 9 114421 317 90513700
Multiple allergies 19.15 9.17 52 114378 15094 90498923
Arthritis bacterial 19.11 9.17 34 114396 7411 90506606
Foetal heart rate abnormal 19.03 9.17 13 114417 949 90513068
Tremor 18.94 9.17 285 114145 152888 90361129
Pupil fixed 18.92 9.17 18 114412 2110 90511907
Post procedural complication 18.92 9.17 60 114370 18982 90495035
Nerve root injury 18.83 9.17 6 114424 71 90513946
Punctate keratitis 18.76 9.17 12 114418 784 90513233
Pancytopenia 18.73 9.17 83 114347 120180 90393837
Bronchitis 18.70 9.17 284 114146 152643 90361374
Trigemino-cardiac reflex 18.68 9.17 6 114424 73 90513944
Acute respiratory failure 18.66 9.17 105 114325 42813 90471204
Foot deformity 18.65 9.17 29 114401 59622 90454395
Lethargy 18.57 9.17 140 114290 62999 90451018
Infusion site warmth 18.57 9.17 18 114412 2160 90511857
Dose calculation error 18.54 9.17 9 114421 342 90513675
Ear infection 18.48 9.17 151 114279 69624 90444393
Wrong product administered 18.40 9.17 34 114396 7631 90506386
Acute kidney injury 18.40 9.17 289 114141 320098 90193919
Neuromuscular block prolonged 18.34 9.17 11 114419 641 90513376
Product administration error 18.32 9.17 74 114356 26349 90487668
Hypoaesthesia oral 18.18 9.17 52 114378 15548 90498469
Autoimmune disorder 18.17 9.17 44 114386 76700 90437317
Atonic urinary bladder 18.11 9.17 7 114423 151 90513866
Lupus-like syndrome 18.06 9.17 21 114409 48825 90465192
Labelled drug-food interaction issue 17.90 9.17 5 114425 36 90513981
Leukopenia 17.89 9.17 66 114364 100644 90413373
Intentional self-injury 17.89 9.17 79 114351 29255 90484762
Nerve block 17.85 9.17 12 114418 853 90513164
Immunodeficiency 17.76 9.17 17 114413 43217 90470800
Muscle spasms 17.75 9.17 218 114212 251665 90262352
Haemoglobin increased 17.73 9.17 33 114397 7448 90506569
Respiratory distress 17.41 9.17 96 114334 38850 90475167
Stress 17.36 9.17 168 114262 81227 90432790
Device infusion issue 17.27 9.17 19 114411 2643 90511374
Paralysis 17.19 9.17 42 114388 11436 90502581
Glossoptosis 17.18 9.17 6 114424 96 90513921
Abortion spontaneous 17.17 9.17 26 114404 54030 90459987
Product dose omission issue 17.14 9.17 486 113944 291201 90222816
Airway peak pressure increased 17.06 9.17 9 114421 409 90513608
Inappropriate schedule of product administration 17.02 9.17 275 114155 149658 90364359
Walking aid user 17.02 9.17 12 114418 35494 90478523
Memory impairment 16.99 9.17 163 114267 197081 90316936
Brachial artery entrapment syndrome 16.92 9.17 5 114425 45 90513972
Vitamin D increased 16.88 9.17 12 114418 934 90513083
Nephrolithiasis 16.86 9.17 113 114317 48972 90465045
Eye movement disorder 16.81 9.17 29 114401 6169 90507848
Product distribution issue 16.74 9.17 22 114408 3683 90510334
Macular degeneration 16.71 9.17 14 114416 37956 90476061
Foetal death 16.67 9.17 3 114427 20720 90493297
Anaphylactoid shock 16.66 9.17 9 114421 429 90513588
Axillary nerve injury 16.64 9.17 5 114425 48 90513969
Substance abuser 16.61 9.17 7 114423 190 90513827
Skin infection 16.58 9.17 55 114375 17809 90496208
Hallucination, tactile 16.58 9.17 9 114421 433 90513584
Laboratory test abnormal 16.57 9.17 17 114413 41837 90472180
Taste disorder 16.46 9.17 33 114397 61513 90452504
Septic shock 16.41 9.17 53 114377 84107 90429910
Hypoproteinaemia 16.32 9.17 20 114410 3122 90510895
Neonatal seizure 16.30 9.17 10 114420 607 90513410
Maternal alcohol use 16.29 9.17 4 114426 16 90514001
Injection site abscess 16.28 9.17 14 114416 1440 90512577
Ataxia 16.26 9.17 55 114375 17987 90496030
Abdominal pain 16.25 9.17 378 114052 395343 90118674
Drug-induced liver injury 16.17 9.17 59 114371 90259 90423758
Coma scale abnormal 16.16 9.17 27 114403 5599 90508418
Retinal artery occlusion 16.13 9.17 17 114413 2254 90511763
Blood pressure immeasurable 15.97 9.17 14 114416 1478 90512539
Congenital umbilical hernia 15.92 9.17 8 114422 328 90513689
Inadequate analgesia 15.91 9.17 20 114410 3204 90510813
Piloerection 15.88 9.17 10 114420 636 90513381
Myelosuppression 15.87 9.17 27 114403 53564 90460453
Analgesic drug level increased 15.85 9.17 19 114411 2900 90511117
Injury 15.78 9.17 166 114264 197183 90316834
Apnoeic attack 15.76 9.17 8 114422 335 90513682
Device expulsion 15.75 9.17 17 114413 40869 90473148
Accidental exposure to product 15.44 9.17 99 114331 42267 90471750
Hypothermia 15.40 9.17 49 114381 15526 90498491
Infusion site discolouration 15.37 9.17 12 114418 1077 90512940
Pre-existing condition improved 15.30 9.17 35 114395 9134 90504883
Procedural complication 15.29 9.17 27 114403 5851 90508166
Drug tolerance decreased 15.22 9.17 11 114419 32119 90481898
Epilepsy 15.18 9.17 53 114377 82153 90431864
Anorgasmia 15.15 9.17 10 114420 690 90513327
Heliotrope rash 15.14 9.17 7 114423 238 90513779
Diplopia 15.06 9.17 74 114356 28640 90485377
Nail bed tenderness 15.03 9.17 8 114422 370 90513647
Vascular stenosis 14.97 9.17 9 114421 527 90513490
Anaphylactoid reaction 14.97 9.17 23 114407 4445 90509572
Supraventricular extrasystoles 14.79 9.17 25 114405 5232 90508785
Eye infarction 14.74 9.17 5 114425 73 90513944
Transferrin decreased 14.64 9.17 8 114422 390 90513627
Finger deformity 14.64 9.17 12 114418 32885 90481132
Brain injury 14.57 9.17 31 114399 7707 90506310
Spinal synovial cyst 14.55 9.17 5 114425 76 90513941
Product contamination 14.49 9.17 12 114418 1172 90512845
Educational problem 14.41 9.17 9 114421 564 90513453
Premenstrual dysphoric disorder 14.37 9.17 5 114425 79 90513938
Oedema peripheral 14.35 9.17 234 114196 257681 90256336
Apgar score low 14.32 9.17 12 114418 1191 90512826
Visual acuity reduced 14.24 9.17 63 114367 23347 90490670
Prescription drug used without a prescription 14.20 9.17 19 114411 3236 90510781
Ventricular arrhythmia 14.13 9.17 22 114408 4299 90509718
Administration site extravasation 14.09 9.17 12 114418 1218 90512799
Left ventricle outflow tract obstruction 14.03 9.17 8 114422 424 90513593
Acute hepatic failure 13.94 9.17 61 114369 22500 90491517
Infusion site infection 13.93 9.17 17 114413 2643 90511374
Tenderness 13.92 9.17 69 114361 26799 90487218
Monoplegia 13.87 9.17 20 114410 3654 90510363
Gastroenteritis 13.85 9.17 10 114420 29219 90484798
Right ventricular dysfunction 13.85 9.17 16 114414 2348 90511669
Delayed recovery from anaesthesia 13.79 9.17 11 114419 1019 90512998
Tonic posturing 13.74 9.17 3 114427 6 90514011
Nerve root injury cervical 13.74 9.17 3 114427 6 90514011
Drug resistance 13.68 9.17 11 114419 30438 90483579
Porphyria acute 13.63 9.17 3 114427 17972 90496045
Face oedema 13.62 9.17 62 114368 23256 90490761
Infantile apnoea 13.62 9.17 12 114418 1275 90512742
Hyperlipasaemia 13.60 9.17 10 114420 821 90513196
Genital erosion 13.52 9.17 8 114422 455 90513562
Chest pain 13.49 9.17 304 114126 319341 90194676
Injection site reaction 13.48 9.17 65 114365 92015 90422002
Device wireless communication issue 13.47 9.17 5 114425 96 90513921
Iron binding capacity total decreased 13.47 9.17 8 114422 458 90513559
Injection site atrophy 13.46 9.17 10 114420 834 90513183
Distributive shock 13.45 9.17 19 114411 3405 90510612
Poikiloderma 13.41 9.17 7 114423 311 90513706
Foreign body in respiratory tract 13.37 9.17 7 114423 313 90513704
Inappropriate antidiuretic hormone secretion 13.36 9.17 4 114426 19501 90494516
Incision site rash 13.35 9.17 4 114426 38 90513979
Dissociative amnesia 13.35 9.17 4 114426 38 90513979
Cardiotoxicity 13.31 9.17 38 114392 11351 90502666
Ejection fraction decreased 13.30 9.17 67 114363 26186 90487831
Localised infection 13.22 9.17 80 114350 33482 90480535
Osteonecrosis of jaw 13.21 9.17 18 114412 39085 90474932
Allergy to immunoglobulin therapy 13.18 9.17 6 114424 197 90513820
Eyelid contusion 13.15 9.17 5 114425 103 90513914
Cardiac failure congestive 13.13 9.17 72 114358 98622 90415395
Multiple organ dysfunction syndrome 13.10 9.17 138 114292 68198 90445819
Parasomnia 13.05 9.17 9 114421 667 90513350
Gastroenteritis viral 13.02 9.17 74 114356 30281 90483736
Intercepted medication error 12.91 9.17 10 114420 887 90513130
Anal sphincter atony 12.91 9.17 7 114423 336 90513681
Quadriparesis 12.88 9.17 16 114414 2533 90511484
Sinusitis bacterial 12.84 9.17 14 114416 1929 90512088
Hepatitis 12.80 9.17 46 114384 70693 90443324
Mean arterial pressure decreased 12.77 9.17 6 114424 212 90513805
Foetal heart rate decreased 12.77 9.17 6 114424 212 90513805
Pancreatitis acute 12.76 9.17 13 114417 32102 90481915
Orbital infection 12.76 9.17 5 114425 112 90513905
Oral herpes 12.63 9.17 79 114351 33445 90480572
Autonomic neuropathy 12.56 9.17 12 114418 1415 90512602
Cancer pain 12.48 9.17 20 114410 4005 90510012
Infusion site oedema 12.47 9.17 11 114419 1170 90512847
Toxicologic test abnormal 12.41 9.17 9 114421 723 90513294
Oedema 12.41 9.17 178 114252 200117 90313900
Infusion site inflammation 12.35 9.17 8 114422 534 90513483
Myocardial ischaemia 12.35 9.17 42 114388 13772 90500245
Vaginal abscess 12.35 9.17 8 114422 534 90513483
Conduction disorder 12.34 9.17 13 114417 1722 90512295
Muscular weakness 12.34 9.17 185 114245 206481 90307536
Alcohol intolerance 12.32 9.17 5 114425 123 90513894
Drug eruption 12.27 9.17 16 114414 35391 90478626
Floppy infant 12.17 9.17 5 114425 127 90513890
Haemangioma congenital 12.17 9.17 8 114422 548 90513469
Anterior chamber fibrin 12.03 9.17 5 114425 131 90513886
Tryptase increased 12.03 9.17 8 114422 559 90513458
Myoclonus 11.98 9.17 52 114378 19116 90494901
Disorientation 11.97 9.17 96 114334 44018 90469999
Implant site swelling 11.96 9.17 8 114422 564 90513453
Tachypnoea 11.96 9.17 56 114374 21253 90492764
Attention deficit hyperactivity disorder 11.91 9.17 20 114410 4164 90509853
Spinal operation 11.90 9.17 34 114396 10162 90503855
Incoherent 11.85 9.17 22 114408 4955 90509062
Hypertension 11.84 9.17 465 113965 457067 90056950
Vascular resistance systemic decreased 11.79 9.17 5 114425 138 90513879
Infusion site streaking 11.77 9.17 8 114422 579 90513438
Product preparation error 11.76 9.17 34 114396 10227 90503790
Interstitial lung disease 11.74 9.17 53 114377 76352 90437665
Body dysmorphic disorder 11.73 9.17 7 114423 404 90513613
Infusion site induration 11.66 9.17 12 114418 1547 90512470
Spinal stroke 11.63 9.17 4 114426 61 90513956
Bradypnoea 11.61 9.17 21 114409 4637 90509380
Multiple injuries 11.57 9.17 13 114417 1852 90512165
Infusion site scar 11.54 9.17 8 114422 598 90513419
Implant site bruising 11.50 9.17 7 114423 419 90513598
Haemoglobin decreased 11.47 9.17 140 114290 161816 90352201
Infection 11.43 9.17 359 114071 361735 90152282
Insomnia 11.43 9.17 327 114103 333147 90180870
Mixed anxiety and depressive disorder 11.40 9.17 7 114423 426 90513591
Renal impairment 11.40 9.17 82 114348 105339 90408678
Conjunctivitis 11.38 9.17 65 114365 26641 90487376
Pupillary reflex impaired 11.33 9.17 15 114415 2530 90511487
Laryngitis 11.32 9.17 30 114400 50723 90463294
Cellulitis 11.31 9.17 170 114260 91167 90422850
Feeling drunk 11.29 9.17 21 114409 4737 90509280
Arthritis fungal 11.28 9.17 4 114426 67 90513950
Tinnitus 11.26 9.17 93 114337 43009 90471008
Femur fracture 11.25 9.17 26 114404 46056 90467961
Peripheral vascular disorder 11.24 9.17 25 114405 6406 90507611
Proctalgia 11.23 9.17 29 114401 8169 90505848
Myocardial depression 11.23 9.17 8 114422 625 90513392
Product contamination microbial 11.22 9.17 6 114424 280 90513737
Asthma 11.18 9.17 227 114203 241933 90272084
Procedural anxiety 11.16 9.17 9 114421 847 90513170
Gastric mucosa erythema 11.09 9.17 7 114423 447 90513570
Cholestasis 11.01 9.17 18 114412 36281 90477736
Anaesthetic complication pulmonary 10.97 9.17 4 114426 73 90513944
Intraocular pressure fluctuation 10.97 9.17 4 114426 73 90513944
Therapy cessation 10.90 9.17 81 114349 36280 90477737
Renal cortical necrosis 10.90 9.17 6 114424 297 90513720
Ischaemia 10.89 9.17 22 114408 5273 90508744
Language disorder 10.84 9.17 15 114415 2637 90511380
Atelectasis 10.80 9.17 60 114370 24349 90489668
Pneumocystis jirovecii pneumonia 10.77 9.17 7 114423 21609 90492408
Birth mark 10.74 9.17 5 114425 173 90513844
Bone marrow failure 10.72 9.17 15 114415 32206 90481811
Upper gastrointestinal haemorrhage 10.71 9.17 8 114422 22968 90491049
Oxygen saturation decreased 10.69 9.17 193 114237 107290 90406727
Administration site erythema 10.68 9.17 9 114421 900 90513117
Hemiplegic migraine 10.68 9.17 5 114425 175 90513842
Exostosis 10.68 9.17 33 114397 53101 90460916
Drug abuser 10.68 9.17 15 114415 2675 90511342
Calcinosis 10.66 9.17 15 114415 2680 90511337
Medication error 10.65 9.17 158 114272 84494 90429523
Akinesia 10.59 9.17 12 114418 1724 90512293
Propionibacterium infection 10.58 9.17 3 114427 23 90513994
Pneumonia aspiration 10.52 9.17 88 114342 40852 90473165
Respiratory alkalosis 10.51 9.17 17 114413 3431 90510586
Sensory loss 10.51 9.17 48 114382 18027 90495990
Eclampsia 10.50 9.17 7 114423 491 90513526
Fear-related avoidance of activities 10.40 9.17 5 114425 186 90513831
Diplegia 10.40 9.17 11 114419 1464 90512553
Rash vesicular 10.35 9.17 5 114425 18192 90495825
Peritonitis 10.35 9.17 6 114424 19699 90494318
Incorrect product formulation administered 10.33 9.17 5 114425 189 90513828
Chemical burn 10.29 9.17 7 114423 508 90513509
Spinal cord oedema 10.28 9.17 5 114425 191 90513826
Hepatic enzyme decreased 10.27 9.17 9 114421 949 90513068
Accelerated idioventricular rhythm 10.27 9.17 4 114426 88 90513929
Maternal exposure timing unspecified 10.26 9.17 8 114422 22475 90491542
Nail bed inflammation 10.24 9.17 12 114418 1789 90512228
Imprisonment 10.22 9.17 6 114424 336 90513681
Blood pressure fluctuation 10.22 9.17 33 114397 52380 90461637
Conjunctival oedema 10.18 9.17 9 114421 960 90513057
Concussion 10.17 9.17 34 114396 11057 90502960
Application site alopecia 10.15 9.17 3 114427 27 90513990
Nodal rhythm 10.14 9.17 12 114418 1806 90512211
Aspiration 10.13 9.17 43 114387 15650 90498367
Impaired driving ability 10.06 9.17 21 114409 5152 90508865
Normal newborn 10.05 9.17 57 114373 23305 90490712
Drug detoxification 10.03 9.17 6 114424 348 90513669
Paraesthesia 10.02 9.17 240 114190 250086 90263931
Electrocardiogram PR shortened 9.97 9.17 7 114423 534 90513483
Nasal mucosal disorder 9.94 9.17 12 114418 1845 90512172
Retinal cyst 9.91 9.17 4 114426 97 90513920
Blood methaemoglobin present 9.91 9.17 4 114426 97 90513920
Spinal cord infarction 9.88 9.17 6 114424 358 90513659
Blood pressure systolic increased 9.87 9.17 39 114391 58306 90455711
Neuromuscular blockade 9.84 9.17 6 114424 360 90513657
Syringomyelia 9.80 9.17 5 114425 212 90513805
Repetitive strain injury 9.80 9.17 5 114425 212 90513805
Cholestasis of pregnancy 9.79 9.17 11 114419 1566 90512451
Pneumonia mycoplasmal 9.77 9.17 9 114421 1013 90513004
Hypoventilation 9.72 9.17 21 114409 5275 90508742
Alcoholic pancreatitis 9.70 9.17 3 114427 32 90513985
Allergy to metals 9.64 9.17 9 114421 1031 90512986
Haemorrhagic vasculitis 9.62 9.17 4 114426 105 90513912
Retinal haemorrhage 9.62 9.17 22 114408 5742 90508275
Coccygectomy 9.61 9.17 3 114427 33 90513984
Sympathectomy 9.61 9.17 3 114427 33 90513984
Incontinence 9.61 9.17 38 114392 13397 90500620
Viral infection 9.59 9.17 87 114343 41327 90472690
Creatinine renal clearance decreased 9.58 9.17 6 114424 18893 90495124
Red blood cell sedimentation rate decreased 9.58 9.17 9 114421 1039 90512978
Hyporesponsive to stimuli 9.57 9.17 11 114419 1606 90512411
Chills 9.52 9.17 226 114204 131755 90382262
Ependymoma 9.51 9.17 4 114426 108 90513909
Drug level above therapeutic 9.50 9.17 22 114408 5787 90508230
Depression 9.49 9.17 298 114132 300303 90213714
Metapneumovirus infection 9.49 9.17 10 114420 1325 90512692
Haemorrhoids 9.49 9.17 62 114368 26640 90487377
Hepatic failure 9.47 9.17 84 114346 39644 90474373
Multiple sclerosis relapse 9.47 9.17 34 114396 52271 90461746
Myasthenia gravis crisis 9.46 9.17 9 114421 1055 90512962
Allergy to chemicals 9.45 9.17 17 114413 3737 90510280
Genital ulceration 9.40 9.17 9 114421 1064 90512953
Disease recurrence 9.39 9.17 21 114409 37632 90476385
Diabetes mellitus inadequate control 9.38 9.17 6 114424 18678 90495339
Exposure via ingestion 9.32 9.17 14 114416 2653 90511364
Poor venous access 9.31 9.17 49 114381 19478 90494539
Foetal methotrexate syndrome 9.31 9.17 4 114426 114 90513903
Anorectal discomfort 9.31 9.17 15 114415 3019 90510998
Cerebral congestion 9.28 9.17 4 114426 115 90513902
Pustular psoriasis 9.26 9.17 6 114424 18550 90495467
Injection site infection 9.25 9.17 13 114417 2319 90511698
Kidney congestion 9.23 9.17 3 114427 38 90513979
Retinal detachment 9.21 9.17 24 114406 6798 90507219

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 5534.72 10.99 3031 76206 101740 42440358
Completed suicide 3576.50 10.99 2222 77015 94243 42447855
Toxicity to various agents 3556.96 10.99 3116 76121 226020 42316078
Cardio-respiratory arrest 727.96 10.99 708 78529 57928 42484170
Local anaesthetic systemic toxicity 600.64 10.99 207 79030 2093 42540005
Overdose 598.26 10.99 851 78386 104413 42437685
Substance use disorder 579.55 10.99 254 78983 5091 42537007
Intentional overdose 549.81 10.99 573 78664 50883 42491215
Drug use disorder 511.44 10.99 288 78949 10045 42532053
Alcohol interaction 454.15 10.99 165 79072 1970 42540128
Alcohol abuse 453.89 10.99 197 79040 3852 42538246
Intentional product misuse 414.15 10.99 542 78695 61358 42480740
Suspected suicide 388.24 10.99 202 79035 5997 42536101
Coma 373.94 10.99 479 78758 53075 42489023
Cardiac arrest 356.91 10.99 689 78548 108631 42433467
Substance abuse 312.60 10.99 199 79038 8706 42533392
Suicide attempt 301.01 10.99 399 78838 45701 42496397
Exposure to toxic agent 282.05 10.99 152 79085 4852 42537246
Poisoning 276.93 10.99 225 79012 14474 42527624
Drug dependence 275.31 10.99 304 78933 28790 42513308
Respiratory arrest 265.51 10.99 295 78942 28129 42513969
Asphyxia 234.01 10.99 162 79075 8164 42533934
Methaemoglobinaemia 232.96 10.99 141 79096 5633 42536465
Miosis 228.70 10.99 194 79043 13252 42528846
Anaphylactic shock 228.16 10.99 249 78988 23268 42518830
Respiratory depression 217.39 10.99 219 79018 18649 42523449
Alcohol poisoning 212.00 10.99 147 79090 7427 42534671
Tachycardia 167.13 10.99 489 78748 100598 42441500
Diarrhoea 161.21 10.99 390 78847 460459 42081639
Incorrect route of product administration 157.99 10.99 210 79027 24095 42518003
Anaphylactic reaction 151.12 10.99 279 78958 42464 42499634
Aggression 150.80 10.99 284 78953 43879 42498219
Inspiratory capacity decreased 150.30 10.99 84 79153 2883 42539215
Poisoning deliberate 147.81 10.99 134 79103 10000 42532098
Alcohol use 129.13 10.99 75 79162 2773 42539325
Prescription drug used without a prescription 118.79 10.99 70 79167 2660 42539438
Mydriasis 114.45 10.99 109 79128 8661 42533437
Death 108.26 10.99 1343 77894 469842 42072256
Anaesthetic complication 107.34 10.99 53 79184 1404 42540694
Agitation 106.09 10.99 311 78926 64003 42478095
Generalised tonic-clonic seizure 104.51 10.99 181 79056 26198 42515900
Fatigue 102.31 10.99 440 78797 435201 42106897
Unresponsive to stimuli 101.10 10.99 197 79040 31206 42510892
Disease progression 97.05 10.99 75 79162 143581 42398517
Hypotension 92.61 10.99 805 78432 256826 42285272
Toxic anterior segment syndrome 91.11 10.99 47 79190 1369 42540729
Blood alcohol increased 90.20 10.99 36 79201 564 42541534
Accidental death 86.65 10.99 60 79177 3023 42539075
Injury 85.64 10.99 151 79086 22165 42519933
Anaemia 81.45 10.99 259 78978 280019 42262079
Depressed level of consciousness 81.04 10.99 234 79003 47736 42494362
Interstitial lung disease 80.48 10.99 23 79214 78439 42463659
Decreased appetite 79.29 10.99 149 79088 192988 42349110
Acute kidney injury 77.83 10.99 385 78852 366952 42175146
Loss of consciousness 77.72 10.99 359 78878 91995 42450103
Weight decreased 76.40 10.99 171 79066 207777 42334321
Rash 74.26 10.99 265 78972 276689 42265409
Bradycardia 73.93 10.99 335 78902 85149 42456949
Neutropenia 69.24 10.99 169 79068 199262 42342836
Dyspnoea 66.19 10.99 517 78720 442104 42099994
Ventricular fibrillation 66.15 10.99 162 79075 29961 42512137
Off label use 65.98 10.99 816 78421 637519 41904579
Suicidal ideation 65.63 10.99 218 79019 47943 42494155
Drug screen positive 64.95 10.99 57 79180 4074 42538024
Electrocardiogram ST segment elevation 64.87 10.99 67 79170 5872 42536226
Asthenia 63.68 10.99 287 78950 280506 42261592
Brain oedema 63.32 10.99 111 79126 16216 42525882
Arthralgia 62.88 10.99 185 79052 205053 42337045
Adulterated product 59.83 10.99 29 79208 737 42541361
Accident 58.13 10.99 66 79171 6437 42535661
Malignant neoplasm progression 57.62 10.99 70 79167 108330 42433768
Electrocardiogram QRS complex prolonged 57.05 10.99 62 79175 5761 42536337
Haemoglobin decreased 56.28 10.99 100 79137 132371 42409727
General physical health deterioration 55.82 10.99 124 79113 151122 42390976
Ventricular tachycardia 55.71 10.99 152 79085 30008 42512090
Emotional distress 55.53 10.99 104 79133 15989 42526109
Behaviour disorder 55.41 10.99 67 79170 6987 42535111
Drug withdrawal syndrome 55.08 10.99 123 79114 21426 42520672
Thrombocytopenia 55.08 10.99 176 79061 190103 42351995
Alcohol withdrawal syndrome 54.86 10.99 34 79203 1417 42540681
Fear 53.95 10.99 83 79154 10882 42531216
Accidental overdose 51.56 10.99 142 79095 28188 42513910
Medication error 51.49 10.99 157 79080 32997 42509101
Cardiac failure congestive 51.33 10.99 50 79187 85552 42456546
Impaired driving ability 50.98 10.99 43 79194 2912 42539186
Pancytopenia 50.81 10.99 88 79149 117655 42424443
Bradypnoea 50.60 10.99 51 79186 4342 42537756
Pyrexia 50.47 10.99 479 78758 393563 42148535
Anal inflammation 48.15 10.99 37 79200 2192 42539906
Pulmonary oedema 47.71 10.99 211 79026 53061 42489037
Dehydration 46.95 10.99 123 79114 141644 42400454
Pain in extremity 45.91 10.99 136 79101 150468 42391630
Altered state of consciousness 45.85 10.99 139 79098 29120 42512978
Pruritus 45.77 10.99 188 79049 188583 42353515
Anhedonia 45.07 10.99 63 79174 7577 42534521
Myocardial infarction 44.66 10.99 103 79134 123906 42418192
Alcohol intolerance 44.65 10.99 19 79218 353 42541745
Somnolence 44.51 10.99 429 78808 140676 42401422
Sinus tachycardia 44.21 10.99 110 79127 20543 42521555
Haematochezia 44.09 10.99 27 79210 58409 42483689
SARS-CoV-2 test negative 44.00 10.99 32 79205 1743 42540355
Tubulointerstitial nephritis 43.93 10.99 4 79233 31544 42510554
Infusion site pain 43.62 10.99 52 79185 5343 42536755
Condition aggravated 43.47 10.99 295 78942 260459 42281639
Cough 43.41 10.99 177 79060 177926 42364172
Rheumatoid arthritis 42.49 10.99 13 79224 42427 42499671
Intentional product use issue 42.29 10.99 253 78984 71580 42470518
White blood cell count decreased 41.96 10.99 89 79148 110307 42431791
Weight increased 41.93 10.99 86 79151 107897 42434201
Renal injury 41.92 10.99 79 79158 12201 42529897
Myalgia 41.27 10.99 72 79165 96008 42446090
Leukopenia 41.06 10.99 47 79190 74699 42467399
Abdominal discomfort 40.61 10.99 48 79189 75207 42466891
Ex-drug abuser 40.54 10.99 12 79225 70 42542028
Psoriasis 40.23 10.99 20 79217 48584 42493514
Asthma 40.21 10.99 34 79203 62280 42479818
Oedema peripheral 39.96 10.99 125 79112 135951 42406147
Spinal cord infarction 39.69 10.99 21 79216 645 42541453
Neuropathy peripheral 38.80 10.99 82 79155 101771 42440327
Apnoea 38.29 10.99 59 79178 7744 42534354
Infusion site erythema 38.01 10.99 40 79197 3582 42538516
Prostate cancer 37.51 10.99 18 79219 44625 42497473
Pneumonia 37.51 10.99 556 78681 421593 42120505
Agranulocytosis 37.43 10.99 6 79231 30606 42511492
Shock 37.18 10.99 129 79108 28992 42513106
Malaise 36.35 10.99 238 78999 211918 42330180
Seizure 36.28 10.99 363 78874 120198 42421900
Road traffic accident 36.03 10.99 97 79140 18996 42523102
Intentional self-injury 35.78 10.99 84 79153 15118 42526980
Cardiogenic shock 35.65 10.99 146 79091 35494 42506604
Behavioural addiction 35.58 10.99 11 79226 76 42542022
Alcoholism 35.56 10.99 35 79202 2895 42539203
Respiratory acidosis 35.56 10.99 51 79186 6280 42535818
Renal impairment 35.45 10.99 97 79140 110131 42431967
Withdrawal syndrome 35.17 10.99 82 79155 14693 42527405
Trigemino-cardiac reflex 35.00 10.99 16 79221 355 42541743
Cauda equina syndrome 34.63 10.99 22 79215 958 42541140
Deep vein thrombosis 34.59 10.99 56 79181 76901 42465197
Hypoxia 34.41 10.99 235 79002 69551 42472547
Platelet count decreased 34.20 10.99 137 79100 138444 42403654
Dyspnoea exertional 34.06 10.99 26 79211 50122 42491976
Hyperthermia malignant 32.72 10.99 32 79205 2626 42539472
Loss of personal independence in daily activities 32.36 10.99 27 79210 49789 42492309
Cytomegalovirus infection 32.15 10.99 10 79227 32296 42509802
Drug abuser 31.84 10.99 36 79201 3495 42538603
Myelosuppression 31.50 10.99 18 79219 40443 42501655
Kounis syndrome 31.50 10.99 35 79202 3333 42538765
Blood ethanol 30.86 10.99 10 79227 82 42542016
Nausea 30.76 10.99 536 78701 396263 42145835
Myoclonus 30.51 10.99 85 79152 16980 42525118
Status epilepticus 30.26 10.99 80 79157 15498 42526600
Restlessness 30.19 10.99 121 79116 29128 42512970
Drug resistance 30.03 10.99 13 79224 34235 42507863
Opiates positive 29.11 10.99 16 79221 531 42541567
Therapeutic product effect incomplete 28.82 10.99 55 79182 70884 42471214
Homicide 28.55 10.99 19 79218 896 42541202
Postmortem blood drug level 28.30 10.99 11 79226 160 42541938
Infusion site extravasation 27.68 10.99 42 79195 5439 42536659
Insurance issue 27.41 10.99 36 79201 4080 42538018
Blood pressure systolic increased 27.22 10.99 9 79228 27959 42514139
Myocardial fibrosis 27.18 10.99 21 79216 1254 42540844
Drug reaction with eosinophilia and systemic symptoms 27.09 10.99 23 79214 42052 42500046
Foetal alcohol syndrome 26.84 10.99 9 79228 83 42542015
Dysarthria 26.56 10.99 145 79092 39662 42502436
Pneumocystis jirovecii pneumonia 26.52 10.99 7 79230 25174 42516924
Melaena 26.42 10.99 20 79217 38726 42503372
Cardiac failure 26.13 10.99 106 79131 106750 42435348
Sensorimotor disorder 25.94 10.99 14 79223 448 42541650
Dizziness 25.79 10.99 318 78919 248936 42293162
Coronary artery disease 25.18 10.99 38 79199 53682 42488416
Amnesia 24.97 10.99 112 79125 28325 42513773
Bronchospasm 24.86 10.99 66 79171 12819 42529279
Hypertonia 24.80 10.99 38 79199 4963 42537135
Arthritis 24.71 10.99 25 79212 42040 42500058
Circulatory collapse 24.57 10.99 98 79139 23538 42518560
Removal of foreign body 24.54 10.99 6 79231 14 42542084
Frequent bowel movements 24.43 10.99 5 79232 21402 42520696
Oculocardiac reflex 24.14 10.99 9 79228 116 42541982
Eczema 24.02 10.99 17 79220 34069 42508029
Metabolic acidosis 24.02 10.99 172 79065 51686 42490412
Dyspepsia 23.81 10.99 25 79212 41327 42500771
Pulmonary fibrosis 23.60 10.99 10 79227 26671 42515427
Pupil fixed 23.45 10.99 23 79214 1894 42540204
Proctalgia 23.43 10.99 45 79192 7048 42535050
Disease recurrence 23.39 10.99 13 79224 29665 42512433
Gastrointestinal haemorrhage 23.23 10.99 98 79139 97628 42444470
Blood ethanol increased 22.97 10.99 13 79224 457 42541641
Hepatic function abnormal 22.72 10.99 38 79199 51529 42490569
Bone marrow failure 22.67 10.99 17 79220 33076 42509022
Angina pectoris 22.41 10.99 17 79220 32879 42509219
Rectal haemorrhage 22.38 10.99 36 79201 49570 42492528
Blood pressure fluctuation 22.37 10.99 11 79226 26897 42515201
Hypoxic-ischaemic encephalopathy 22.32 10.99 37 79200 5165 42536933
Anaesthetic complication neurological 22.29 10.99 15 79222 721 42541377
Toxicologic test abnormal 22.23 10.99 13 79224 487 42541611
Hypothermia 22.04 10.99 62 79175 12453 42529645
Delirium tremens 21.87 10.99 14 79223 618 42541480
Gastrointestinal disorder 21.86 10.99 33 79204 46620 42495478
Septic shock 21.75 10.99 92 79145 91580 42450518
Postmortem blood drug level increased 21.73 10.99 13 79224 508 42541590
Ventricular tachyarrhythmia 21.70 10.99 12 79225 403 42541695
Acute pulmonary oedema 21.68 10.99 49 79188 8602 42533496
Blood creatinine increased 21.66 10.99 118 79119 109885 42432213
Somnambulism 21.40 10.99 29 79208 3386 42538712
Wrong product administered 21.18 10.99 40 79197 6186 42535912
Hypercalcaemia 21.07 10.99 4 79233 18054 42524044
Dextrocardia 21.03 10.99 7 79230 63 42542035
Haemodynamic instability 20.95 10.99 61 79176 12496 42529602
Administration related reaction 20.92 10.99 9 79228 172 42541926
Colitis 20.82 10.99 34 79203 46538 42495560
Haematuria 20.80 10.99 48 79189 57751 42484347
Chronic kidney disease 20.64 10.99 35 79202 47206 42494892
Embolia cutis medicamentosa 20.64 10.99 11 79226 343 42541755
Liver disorder 20.63 10.99 26 79211 39618 42502480
Arthropathy 20.54 10.99 15 79222 29582 42512516
Macular ischaemia 20.50 10.99 9 79228 181 42541917
Diabetic ketoacidosis 20.40 10.99 8 79229 22359 42519739
Joint swelling 20.29 10.99 62 79175 67960 42474138
Drug level increased 19.94 10.99 99 79138 26101 42515997
Transient ischaemic attack 19.88 10.99 20 79217 33719 42508379
Open globe injury 19.86 10.99 7 79230 76 42542022
Tracheitis 19.76 10.99 16 79221 1023 42541075
Corneal oedema 19.74 10.99 19 79218 1529 42540569
Neoplasm progression 19.73 10.99 15 79222 28985 42513113
Alcoholic coma 19.70 10.99 7 79230 78 42542020
Full blood count abnormal 19.64 10.99 16 79221 29860 42512238
Drug ineffective for unapproved indication 19.60 10.99 150 79087 46013 42496085
Product administration interrupted 19.56 10.99 34 79203 4932 42537166
Negative pressure pulmonary oedema 19.56 10.99 13 79224 612 42541486
Abnormal behaviour 19.47 10.99 99 79138 26352 42515746
Infusion site swelling 19.20 10.99 27 79210 3265 42538833
Physical assault 19.19 10.99 16 79221 1066 42541032
Blood phosphorus increased 19.15 10.99 59 79178 12466 42529632
Retinal artery occlusion 18.99 10.99 22 79215 2193 42539905
C-reactive protein increased 18.91 10.99 58 79179 63502 42478596
Vasoplegia syndrome 18.90 10.99 24 79213 2631 42539467
Underdose 18.80 10.99 4 79233 16662 42525436
Brain stem syndrome 18.61 10.99 13 79224 664 42541434
Tryptase increased 18.53 10.99 10 79227 320 42541778
Colitis ulcerative 18.51 10.99 13 79224 26162 42515936
Plasma cell myeloma 18.36 10.99 38 79199 47540 42494558
Constipation 18.33 10.99 203 79034 162088 42380010
Dry skin 18.33 10.99 39 79198 48299 42493799
Dysgeusia 18.23 10.99 22 79215 34167 42507931
Proteinuria 18.21 10.99 10 79227 22973 42519125
Respiratory tract infection bacterial 18.13 10.99 20 79217 1889 42540209
Sleep disorder due to a general medical condition 18.10 10.99 5 79232 17448 42524650
Sinusitis 18.08 10.99 150 79087 47142 42494956
Spinal meningeal cyst 18.00 10.99 7 79230 102 42541996
Mental status changes 17.97 10.99 137 79100 41978 42500120
Substance-induced mood disorder 17.93 10.99 6 79231 55 42542043
Chemical burn 17.90 10.99 10 79227 343 42541755
Abdominal pain 17.85 10.99 248 78989 190223 42351875
Jaundice 17.67 10.99 23 79214 34566 42507532
Mean arterial pressure increased 17.64 10.99 6 79231 58 42542040
Postoperative delirium 17.62 10.99 12 79225 588 42541510
Torsade de pointes 17.58 10.99 45 79192 8549 42533549
Neutrophil count decreased 17.39 10.99 60 79177 63355 42478743
International normalised ratio increased 17.33 10.99 40 79197 48128 42493970
Visceral oedema 17.20 10.99 6 79231 63 42542035
Cerebrovascular accident 17.12 10.99 108 79129 97052 42445046
Lymphoma 17.08 10.99 3 79234 14318 42527780
Bezoar 16.91 10.99 16 79221 1260 42540838
Stress 16.77 10.99 140 79097 44072 42498026
Syncope 16.75 10.99 112 79125 99294 42442804
Amphetamines positive 16.70 10.99 8 79229 198 42541900
Hyperkalaemia 16.57 10.99 85 79152 80373 42461725
Mobility decreased 16.52 10.99 25 79212 35281 42506817
Peritonitis 16.45 10.99 7 79230 18626 42523472
Analgesic therapy 16.40 10.99 37 79200 6487 42535611
Pneumonitis 16.37 10.99 33 79204 41685 42500413
Hepatitis 16.29 10.99 16 79221 27284 42514814
Lagophthalmos 16.26 10.99 7 79230 134 42541964
Therapeutic product effect decreased 16.21 10.99 30 79207 39120 42502978
Paraesthesia oral 16.13 10.99 32 79205 5131 42536967
Brachial plexus injury 16.12 10.99 6 79231 77 42542021
Suicidal behaviour 16.09 10.99 17 79220 1529 42540569
Haemoptysis 16.08 10.99 39 79198 46128 42495970
Substance use 16.04 10.99 18 79219 1733 42540365
Chemical submission 15.98 10.99 6 79231 79 42542019
Aqueous fibrin 15.98 10.99 6 79231 79 42542019
Orthostatic hypotension 15.95 10.99 20 79217 30550 42511548
Postictal state 15.89 10.99 14 79223 1006 42541092
Appendicolith 15.80 10.99 58 79179 13398 42528700
Thrombotic microangiopathy 15.78 10.99 4 79233 14778 42527320
Cardiac disorder 15.76 10.99 43 79194 48889 42493209
Psychiatric disorder prophylaxis 15.76 10.99 5 79232 38 42542060
Ear infection 15.72 10.99 56 79181 12748 42529350
Bladder cancer 15.71 10.99 6 79231 17041 42525057
Eosinophilia 15.68 10.99 23 79214 32876 42509222
Muscular weakness 15.66 10.99 91 79146 83407 42458691
Intracranial hypotension 15.63 10.99 10 79227 441 42541657
Toxic leukoencephalopathy 15.56 10.99 12 79225 715 42541383
Brugada syndrome 15.50 10.99 14 79223 1039 42541059
Sepsis 15.47 10.99 269 78968 199065 42343033
Red blood cell count decreased 15.46 10.99 23 79214 32692 42509406
Alopecia 15.44 10.99 19 79218 29257 42512841
Diabetes insipidus 15.39 10.99 26 79211 3687 42538411
Neuromuscular blockade 15.27 10.99 9 79228 342 42541756
Infection 15.24 10.99 134 79103 111934 42430164
Hyperaesthesia 15.24 10.99 34 79203 5918 42536180
Hyperphosphataemia 15.22 10.99 56 79181 12948 42529150
Lip haemorrhage 15.08 10.99 13 79224 907 42541191
Peripheral swelling 15.06 10.99 102 79135 90168 42451930
Self-medication 15.06 10.99 24 79213 3242 42538856
Seizure like phenomena 15.01 10.99 14 79223 1083 42541015
Polyneuropathy 14.96 10.99 8 79229 18653 42523445
Multiple sclerosis relapse 14.96 10.99 4 79233 14260 42527838
Musculoskeletal stiffness 14.94 10.99 56 79181 57709 42484389
Pulse absent 14.93 10.99 35 79202 6292 42535806
Wheezing 14.91 10.99 52 79185 54729 42487369
Analgesic drug level increased 14.89 10.99 14 79223 1094 42541004
Reperfusion arrhythmia 14.86 10.99 6 79231 97 42542001
Accidental poisoning 14.84 10.99 15 79222 1281 42540817
Electrocution 14.75 10.99 4 79233 16 42542082
Hypothyroidism 14.74 10.99 23 79214 32061 42510037
Drug therapy 14.74 10.99 35 79202 6345 42535753
Mucosal inflammation 14.73 10.99 45 79192 49329 42492769
Drowning 14.65 10.99 10 79227 492 42541606
Cardiac murmur 14.55 10.99 3 79234 12772 42529326
Postmortem blood drug level abnormal 14.52 10.99 9 79228 375 42541723
Endophthalmitis 14.49 10.99 28 79209 4405 42537693
Product administration error 14.45 10.99 70 79167 18273 42523825
Product adhesion issue 14.45 10.99 17 79220 1722 42540376
Neurotoxicity 14.36 10.99 84 79153 23567 42518531
Injection site ulcer 14.35 10.99 9 79228 383 42541715
Haemophagocytic lymphohistiocytosis 14.33 10.99 8 79229 18214 42523884
Dysphagia 14.31 10.99 78 79159 72641 42469457
Infusion site irritation 14.27 10.99 9 79228 387 42541711
Patient uncooperative 14.19 10.99 11 79226 660 42541438
Acute myocardial infarction 14.02 10.99 58 79179 58107 42483991
Sleep disorder therapy 14 10.99 36 79201 6858 42535240
Blood glucose increased 13.99 10.99 80 79157 73619 42468479
Respiratory paralysis 13.88 10.99 6 79231 116 42541982
Anxiety 13.88 10.99 303 78934 118257 42423841
Ventricular asystole 13.87 10.99 8 79229 292 42541806
Clostridium difficile infection 13.85 10.99 13 79224 22646 42519452
Hepatic fibrosis 13.81 10.99 29 79208 4843 42537255
Gun shot wound 13.74 10.99 13 79224 1024 42541074
Pericarditis 13.67 10.99 4 79233 13440 42528658
Lymphopenia 13.62 10.99 12 79225 21551 42520547
Full blood count decreased 13.53 10.99 11 79226 20549 42521549
Synovitis 13.50 10.99 6 79231 15561 42526537
Benzodiazepine drug level therapeutic 13.42 10.99 4 79233 24 42542074
Accidental exposure to product 13.41 10.99 74 79163 20319 42521779
Psoriatic arthropathy 13.38 10.99 16 79221 24951 42517147
Alcoholic pancreatitis 13.32 10.99 7 79230 212 42541886
Insomnia 13.31 10.99 148 79089 118105 42423993
Type 2 diabetes mellitus 13.29 10.99 9 79228 18462 42523636
Pneumonia aspiration 13.26 10.99 147 79090 49931 42492167
Vasculitis 13.19 10.99 9 79228 18385 42523713
Metastases to liver 13.09 10.99 7 79230 16319 42525779
Catecholamine crisis 13.04 10.99 5 79232 70 42542028
Respiratory tract infection viral 13.00 10.99 23 79214 3383 42538715
Type I hypersensitivity 12.98 10.99 18 79219 2148 42539950
Screaming 12.92 10.99 17 79220 1930 42540168
Nystagmus 12.90 10.99 30 79207 5366 42536732
Pleural effusion 12.85 10.99 117 79120 97049 42445049
Drug interaction 12.83 10.99 613 78624 266386 42275712
Kidney congestion 12.81 10.99 9 79228 464 42541634
Administration site pain 12.80 10.99 9 79228 465 42541633
Ophthalmoplegia 12.76 10.99 18 79219 2182 42539916
Infusion site bruising 12.74 10.99 12 79225 940 42541158
Psychotic behaviour 12.72 10.99 12 79225 942 42541156
Unevaluable event 12.70 10.99 108 79129 34180 42507918
Lung disorder 12.70 10.99 46 79191 47877 42494221
Product prescribing error 12.69 10.99 18 79219 26094 42516004
Muscle spasms 12.54 10.99 101 79136 85943 42456155
Prostatic pain 12.54 10.99 8 79229 351 42541747
Abdominal pain upper 12.49 10.99 96 79141 82513 42459585
Drug diversion 12.37 10.99 12 79225 975 42541123
Potentiating drug interaction 12.34 10.99 33 79204 6435 42535663
Myasthenia gravis 12.30 10.99 61 79176 16076 42526022
Pulmonary embolism 12.19 10.99 153 79084 119459 42422639
Blood pH decreased 12.16 10.99 18 79219 2280 42539818
Gastritis 12.15 10.99 16 79221 23931 42518167
Corneal opacity 12.14 10.99 10 79227 655 42541443
Thyrotoxic crisis 12.10 10.99 11 79226 823 42541275
Anal sphincter atony 12.05 10.99 6 79231 162 42541936
Vitreous disorder 11.98 10.99 6 79231 164 42541934
Intestinal obstruction 11.98 10.99 20 79217 27138 42514960
Electrocardiogram QT prolonged 11.91 10.99 139 79098 47806 42494292
Upper gastrointestinal haemorrhage 11.86 10.99 24 79213 30275 42511823
Gastroenteritis 11.86 10.99 8 79229 16441 42525657
Device effect incomplete 11.82 10.99 4 79233 38 42542060
Spinal operation 11.82 10.99 25 79212 4195 42537903
Diabetes mellitus inadequate control 11.76 10.99 7 79230 15383 42526715
Painful ejaculation 11.69 10.99 6 79231 173 42541925
Encephalomalacia 11.64 10.99 12 79225 1049 42541049
Coma scale abnormal 11.60 10.99 26 79211 4539 42537559
Sopor 11.59 10.99 52 79185 13150 42528948
Phlebitis superficial 11.58 10.99 7 79230 279 42541819
Impaired work ability 11.58 10.99 4 79233 12087 42530011
Blood lactic acid increased 11.49 10.99 37 79200 8002 42534096
Enterobacter pneumonia 11.44 10.99 9 79228 552 42541546
Palpitations 11.42 10.99 52 79185 50745 42491353
Electrocardiogram T wave amplitude increased 11.32 10.99 5 79232 102 42541996
Hanging 11.32 10.99 6 79231 185 42541913
Pulseless electrical activity 11.31 10.99 38 79199 8399 42533699
Chemical poisoning 11.28 10.99 5 79232 103 42541995
Phaeochromocytoma crisis 11.23 10.99 5 79232 104 42541994
Alcoholic liver disease 11.22 10.99 9 79228 568 42541530
Hypoventilation 11.21 10.99 23 79214 3779 42538319
Pancreatitis acute 11.18 10.99 29 79208 33535 42508563
Graft versus host disease 11.18 10.99 5 79232 12920 42529178
Laryngospasm 11.14 10.99 16 79221 1972 42540126
Conjunctival scar 11.14 10.99 7 79230 299 42541799
Nephropathy toxic 11.09 10.99 9 79228 16829 42525269
Aspergillus infection 11.02 10.99 8 79229 15829 42526269
Laboratory test abnormal 11.01 10.99 16 79221 22962 42519136

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8651.90 9.65 5014 158103 237367 110188815
Drug abuse 7522.27 9.65 4112 159005 173299 110252883
Toxicity to various agents 7066.25 9.65 5746 157371 474809 109951373
Cardio-respiratory arrest 1874.10 9.65 1472 161645 114364 110311818
Local anaesthetic systemic toxicity 1586.78 9.65 505 162612 5032 110421150
Intentional overdose 1125.69 9.65 1172 161945 131329 110294853
Cardiac arrest 1054.68 9.65 1373 161744 195380 110230802
Overdose 1026.21 9.65 1481 161636 232313 110193869
Alcohol interaction 828.72 9.65 280 162837 3414 110422768
Substance use disorder 824.70 9.65 334 162783 6956 110419226
Suspected suicide 819.03 9.65 415 162702 14784 110411398
Drug use disorder 707.72 9.65 399 162718 17675 110408507
Intentional product misuse 652.52 9.65 889 162228 132015 110294167
Exposure to toxic agent 651.98 9.65 337 162780 12521 110413661
Respiratory arrest 594.81 9.65 570 162547 57729 110368453
Suicide attempt 550.98 9.65 720 162397 102674 110323508
Coma 541.91 9.65 764 162353 117105 110309077
Death 541.72 9.65 2250 160867 696619 109729563
Anaphylactic shock 493.98 9.65 487 162630 51059 110375123
Alcohol abuse 470.29 9.65 200 162917 4729 110421453
Methaemoglobinaemia 469.75 9.65 242 162875 8926 110417256
Alcohol poisoning 388.35 9.65 212 162905 8808 110417374
Substance abuse 379.80 9.65 234 162883 12229 110413953
Poisoning 370.00 9.65 322 162795 28783 110397399
Anaphylactic reaction 369.74 9.65 630 162487 113670 110312512
Drug dependence 331.80 9.65 389 162728 49631 110376551
Synovitis 318.69 9.65 22 163095 274070 110152112
Maternal exposure during delivery 305.21 9.65 134 162983 3431 110422751
Toxic anterior segment syndrome 302.75 9.65 132 162985 3322 110422860
Hypotension 283.53 9.65 1521 161596 522328 109903854
Generalised tonic-clonic seizure 282.21 9.65 375 162742 54305 110371877
Victim of crime 275.81 9.65 96 163021 1287 110424895
Poisoning deliberate 275.23 9.65 261 162856 26070 110400112
Miosis 266.98 9.65 237 162880 21746 110404436
Tachycardia 256.21 9.65 826 162291 225819 110200363
Respiratory depression 255.25 9.65 274 162843 31727 110394455
Asphyxia 249.83 9.65 190 162927 14025 110412157
Mydriasis 247.70 9.65 228 162889 21929 110404253
Alcohol use 244.02 9.65 120 162997 4002 110422180
Hand deformity 238.85 9.65 23 163094 218483 110207699
Systemic lupus erythematosus 237.18 9.65 44 163073 254294 110171888
Pericarditis 237.06 9.65 24 163093 219090 110207092
Pemphigus 236.10 9.65 22 163095 214548 110211634
Hepatic enzyme increased 234.37 9.65 90 163027 320802 110105380
Agitation 234.01 9.65 516 162601 112535 110313647
Joint swelling 230.47 9.65 189 162928 442656 109983526
Glossodynia 216.71 9.65 34 163083 221970 110204212
Anaesthetic complication 213.54 9.65 105 163012 3501 110422681
Helicobacter infection 210.20 9.65 15 163102 181862 110244320
Diarrhoea 209.95 9.65 917 162200 1138588 109287594
Incorrect route of product administration 203.00 9.65 350 162767 63711 110362471
Abdominal discomfort 201.32 9.65 171 162946 393687 110032495
Seizure 201.12 9.65 750 162367 220435 110205747
General physical health deterioration 200.39 9.65 199 162918 425096 110001086
Unresponsive to stimuli 200.15 9.65 347 162770 63443 110362739
Anti-cyclic citrullinated peptide antibody positive 194.10 9.65 21 163096 181963 110244219
Aggression 192.22 9.65 327 162790 58883 110367299
Infusion related reaction 184.60 9.65 174 162943 380988 110045194
Duodenal ulcer perforation 183.32 9.65 23 163094 177677 110248505
Mobility decreased 182.85 9.65 61 163056 237361 110188821
Arthralgia 180.23 9.65 571 162546 779061 109647121
Loss of consciousness 175.41 9.65 662 162455 195644 110230538
Alopecia 172.57 9.65 170 162947 364583 110061599
Kounis syndrome 172.32 9.65 108 163009 5817 110420365
Psoriatic arthropathy 165.30 9.65 43 163074 196718 110229464
Bradycardia 164.21 9.65 554 162563 154963 110271219
Arthropathy 156.71 9.65 117 163000 287405 110138777
Somnolence 156.07 9.65 857 162260 296592 110129590
Folliculitis 154.15 9.65 30 163087 167623 110258559
Wound 153.36 9.65 77 163040 234360 110191822
Rheumatoid factor positive 151.69 9.65 11 163106 131629 110294553
Rash 148.87 9.65 664 162453 820300 109605882
Blood alcohol increased 147.74 9.65 56 163061 970 110425212
Muscle injury 143.36 9.65 19 163098 140788 110285394
Ventricular fibrillation 143.22 9.65 235 162882 41078 110385104
Inspiratory capacity decreased 143.12 9.65 72 163045 2523 110423659
Type 2 diabetes mellitus 142.77 9.65 42 163075 177190 110248992
Ventricular tachycardia 142.69 9.65 261 162856 49748 110376434
Chemical submission 142.16 9.65 47 163070 533 110425649
Electrocardiogram QRS complex prolonged 141.69 9.65 132 162985 12889 110413293
Depressed level of consciousness 141.36 9.65 425 162692 111853 110314329
Drug intolerance 138.42 9.65 242 162875 406270 110019912
Rheumatic fever 136.34 9.65 12 163105 122567 110303615
Impaired healing 135.75 9.65 60 163057 196657 110229525
Fatigue 134.62 9.65 1148 161969 1214810 109211372
Therapeutic product effect decreased 124.85 9.65 106 163011 244210 110181972
Rheumatoid arthritis 123.74 9.65 156 162961 299457 110126725
Sinus tachycardia 122.90 9.65 229 162888 44264 110381918
Prescription drug used without a prescription 120.53 9.65 84 163033 5412 110420770
Contraindicated product administered 118.19 9.65 115 163002 248152 110178030
Accidental death 117.98 9.65 80 163037 4929 110421253
Irritable bowel syndrome 116.64 9.65 48 163069 164167 110262015
Asthenia 115.54 9.65 573 162544 688426 109737756
Anaesthetic complication neurological 112.28 9.65 46 163071 987 110425195
Pulseless electrical activity 112.22 9.65 131 162986 16626 110409556
Stress cardiomyopathy 111.63 9.65 127 162990 15679 110410503
Pulmonary oedema 111.04 9.65 364 162753 100295 110325887
Osteoarthritis 106.51 9.65 69 163048 182554 110243628
Sleep disorder due to general medical condition, insomnia type 105.77 9.65 15 163102 105628 110320554
Lower respiratory tract infection 105.22 9.65 122 162995 242984 110183198
Ill-defined disorder 104.86 9.65 50 163067 156803 110269379
Apnoea 103.89 9.65 114 163003 13525 110412657
Electrocardiogram ST segment elevation 103.82 9.65 95 163022 9065 110417117
Decreased appetite 103.22 9.65 358 162759 475488 109950694
Fear 100.11 9.65 146 162971 23047 110403135
Abdominal pain upper 99.81 9.65 230 162887 348881 110077301
Cardiogenic shock 99.18 9.65 244 162873 57094 110369088
Peripheral venous disease 96.99 9.65 7 163110 84110 110342072
Suicidal ideation 95.92 9.65 331 162786 93606 110332576
Swelling 95.81 9.65 237 162880 350804 110075378
Weight increased 92.84 9.65 313 162804 419331 110006851
Facet joint syndrome 91.85 9.65 16 163101 96812 110329370
Lip dry 91.80 9.65 18 163099 100065 110326117
Fibromyalgia 91.22 9.65 71 163046 170838 110255344
Nasopharyngitis 90.79 9.65 289 162828 394072 110032110
Disease progression 90.76 9.65 137 162980 243897 110182285
Inflammation 90.24 9.65 91 163026 193147 110233035
Brain oedema 89.59 9.65 163 162954 30935 110395247
Obesity 89.22 9.65 28 163089 113323 110312859
Procedural hypotension 89.21 9.65 52 163065 2453 110423729
Stomatitis 89.12 9.65 164 162953 270078 110156104
Accidental overdose 89.04 9.65 220 162897 51614 110374568
Hypersensitivity 88.91 9.65 302 162815 403696 110022486
Gait inability 88.84 9.65 45 163072 136331 110289851
Withdrawal syndrome 88.53 9.65 163 162954 31217 110394965
Drug interaction 87.88 9.65 1125 161992 499058 109927124
Pruritus 87.23 9.65 502 162615 581058 109845124
Peripheral swelling 86.90 9.65 305 162812 403729 110022453
Musculoskeletal stiffness 86.90 9.65 176 162941 279646 110146536
Blister 86.16 9.65 126 162991 227250 110198932
Mental status changes 85.50 9.65 277 162840 75845 110350337
Status epilepticus 85.33 9.65 161 162956 31410 110394772
Gastrointestinal disorder 84.16 9.65 142 162975 241810 110184372
Swollen joint count increased 83.47 9.65 12 163105 83649 110342533
Shock 83.29 9.65 219 162898 53369 110372813
Condition aggravated 83.20 9.65 689 162428 734147 109692035
Emotional distress 83.10 9.65 196 162921 44651 110381531
Hypoxia 80.22 9.65 391 162726 129124 110297058
Hypercholesterolaemia 79.89 9.65 18 163099 90819 110335363
Behaviour disorder 79.39 9.65 84 163033 9563 110416619
Pulse absent 78.51 9.65 90 163027 11202 110414980
Nystagmus 78.35 9.65 91 163026 11486 110414696
Body tinea 78.23 9.65 45 163072 2070 110424112
C-reactive protein increased 77.55 9.65 126 162991 217793 110208389
Sulphaemoglobinaemia 76.83 9.65 30 163087 565 110425617
Renal injury 76.74 9.65 115 163002 18598 110407584
Wheezing 76.32 9.65 164 162953 255066 110171116
Off label use 75.14 9.65 1665 161452 1498520 108927662
Neutropenia 74.53 9.65 292 162825 374328 110051854
Malaise 74.18 9.65 634 162483 671185 109754997
Pulmonary fibrosis 73.80 9.65 29 163088 102013 110324169
Embolia cutis medicamentosa 72.23 9.65 33 163084 930 110425252
Bursitis 71.86 9.65 52 163065 129866 110296316
Drug screen positive 71.71 9.65 66 163051 6344 110419838
Postmortem blood drug level abnormal 71.27 9.65 29 163088 611 110425571
Circulatory collapse 71.25 9.65 180 162937 42813 110383369
Thrombocytopenia 70.64 9.65 270 162847 348615 110077567
Altered state of consciousness 69.57 9.65 215 162902 57411 110368771
Anhedonia 69.33 9.65 99 163018 15329 110410853
Victim of chemical submission 68.70 9.65 31 163086 848 110425334
Corneal oedema 68.42 9.65 48 163069 3125 110423057
Joint range of motion decreased 68.39 9.65 48 163069 121784 110304398
Cauda equina syndrome 67.61 9.65 41 163076 2081 110424101
Restlessness 66.17 9.65 208 162909 56051 110370131
Drug level increased 66.15 9.65 187 162930 47532 110378650
Alcoholism 66.13 9.65 50 163067 3657 110422525
Dyspnoea 65.64 9.65 1194 161923 1105678 109320504
Alcohol withdrawal syndrome 64.91 9.65 40 163077 2090 110424092
Weight decreased 64.90 9.65 414 162703 467643 109958539
Bronchospasm 64.77 9.65 140 162977 30099 110396083
Lung disorder 64.15 9.65 104 163013 179943 110246239
Respiratory acidosis 64.02 9.65 90 163027 13736 110412446
Pyrexia 63.44 9.65 938 162179 897327 109528855
Electrocardiogram QT prolonged 63.26 9.65 323 162794 108637 110317545
Breast cancer stage III 63.24 9.65 19 163098 79098 110347084
Psoriasis 63.02 9.65 68 163049 139925 110286257
Interstitial lung disease 62.36 9.65 68 163049 139266 110286916
Victim of sexual abuse 62.00 9.65 25 163092 514 110425668
Liver disorder 61.94 9.65 71 163046 142172 110284010
Acute kidney injury 61.77 9.65 619 162498 634811 109791371
Grip strength decreased 60.99 9.65 21 163096 80153 110346029
Drug withdrawal syndrome 60.65 9.65 157 162960 37897 110388285
Bradypnoea 60.24 9.65 69 163048 8580 110417602
Hyperthermia malignant 59.59 9.65 48 163069 3852 110422330
Underdose 59.19 9.65 11 163106 63543 110362639
Haematochezia 57.92 9.65 51 163066 115473 110310709
Dyspepsia 57.67 9.65 122 162995 190843 110235339
Arthritis 57.67 9.65 99 163018 167487 110258695
Prescribed underdose 57.14 9.65 13 163104 65161 110361021
Wound infection 56.84 9.65 36 163081 96429 110329753
Tracheal deviation 56.80 9.65 20 163097 278 110425904
Metabolic acidosis 56.73 9.65 294 162823 99450 110326732
Insurance issue 56.62 9.65 74 163043 10538 110415644
Adverse event 55.81 9.65 47 163070 108762 110317420
Deep vein thrombosis postoperative 55.79 9.65 10 163107 59281 110366901
Postmortem blood drug level 55.40 9.65 20 163097 300 110425882
Night sweats 55.02 9.65 70 163047 133913 110292269
Adulterated product 54.91 9.65 29 163088 1126 110425056
Extradural haematoma 54.77 9.65 43 163074 3326 110422856
Trigemino-cardiac reflex 54.71 9.65 22 163095 449 110425733
Product adhesion issue 54.64 9.65 41 163076 2965 110423217
Medication error 54.11 9.65 302 162815 105064 110321118
Nail disorder 54.02 9.65 10 163107 57925 110368257
Red blood cell sedimentation rate increased 53.81 9.65 24 163093 78278 110347904
Pancytopenia 53.71 9.65 146 162971 209467 110216715
Phrenic nerve paralysis 53.30 9.65 23 163094 564 110425618
Myelosuppression 53.17 9.65 37 163080 94303 110331879
Malignant neoplasm progression 53.15 9.65 111 163006 174456 110251726
Pain in extremity 53.12 9.65 461 162656 486657 109939525
Loss of personal independence in daily activities 53.12 9.65 87 163030 149933 110276249
Drug hypersensitivity 53.03 9.65 422 162695 453668 109972514
Colitis ulcerative 52.72 9.65 24 163093 77339 110348843
Haemodynamic instability 52.54 9.65 109 163008 22779 110403403
Anal inflammation 52.07 9.65 37 163080 2459 110423723
Blood ethanol 51.41 9.65 15 163102 108 110426074
Dysarthria 51.39 9.65 253 162864 83868 110342314
Blood cholesterol increased 50.97 9.65 124 162993 184661 110241521
Spinal cord infarction 50.59 9.65 27 163090 1071 110425111
Therapy interrupted 50.36 9.65 175 162942 49647 110376535
Accident 50.28 9.65 71 163046 10881 110415301
Lagophthalmos 50.15 9.65 22 163095 562 110425620
Oedema peripheral 50.12 9.65 282 162835 328378 110097804
Dislocation of vertebra 49.38 9.65 4 163113 43717 110382465
Onychomadesis 49.36 9.65 5 163112 45658 110380524
Extradural abscess 49.13 9.65 33 163084 2001 110424181
Anaemia 49.05 9.65 543 162574 546543 109879639
Opiates positive 48.72 9.65 25 163092 914 110425268
Asthma 48.54 9.65 197 162920 250094 110176088
Drug ineffective for unapproved indication 48.40 9.65 288 162829 102550 110323632
Blood ethanol increased 48.18 9.65 22 163095 619 110425563
Unevaluable event 48.17 9.65 194 162923 59033 110367149
Bone erosion 47.81 9.65 6 163111 46365 110379817
Frequent bowel movements 47.33 9.65 23 163094 71367 110354815
C-reactive protein abnormal 47.06 9.65 74 163043 129621 110296561
Neurotoxicity 46.86 9.65 153 162964 42054 110384128
Removal of foreign body 46.85 9.65 11 163106 28 110426154
Endophthalmitis 46.68 9.65 59 163058 8128 110418054
Drug reaction with eosinophilia and systemic symptoms 46.53 9.65 32 163085 82063 110344119
Infusion site pain 46.04 9.65 88 163029 17331 110408851
Brain stem syndrome 45.59 9.65 27 163090 1312 110424870
SARS-CoV-2 test negative 45.11 9.65 32 163085 2121 110424061
Homicide 44.87 9.65 25 163092 1081 110425101
Infection susceptibility increased 44.82 9.65 43 163074 4355 110421827
Lower limb fracture 44.56 9.65 28 163089 75320 110350862
Amnesia 44.46 9.65 287 162830 105121 110321061
Blepharospasm 44.15 9.65 13 163104 54838 110371344
Paranasal cyst 43.83 9.65 23 163094 881 110425301
Intentional self-injury 43.66 9.65 138 162979 37291 110388891
Cyanosis 43.64 9.65 119 162998 29622 110396560
Coeliac disease 43.54 9.65 6 163111 43181 110383001
Discomfort 43.53 9.65 166 162951 214541 110211641
Prescribed overdose 43.50 9.65 39 163078 87542 110338640
Hypoaesthesia 43.49 9.65 278 162839 313945 110112237
Vascular malformation 43.18 9.65 22 163095 792 110425390
Infection 43.01 9.65 335 162782 361865 110064317
Impaired driving ability 42.99 9.65 50 163067 6320 110419862
Cardiac failure congestive 42.69 9.65 100 163017 150900 110275282
Drug abuser 42.57 9.65 46 163071 5363 110420819
Headache 42.36 9.65 985 162132 881392 109544790
Therapeutic product effect incomplete 42.24 9.65 178 162939 223627 110202555
Wrong product administered 41.62 9.65 65 163052 10895 110415287
Treatment failure 41.11 9.65 240 162877 276994 110149188
Inhibitory drug interaction 40.57 9.65 43 163074 4904 110421278
Nausea 40.27 9.65 1455 161662 1234235 109191947
Product administration interrupted 40.17 9.65 65 163052 11227 110414955
Leukopenia 40.12 9.65 101 163016 148690 110277492
Behavioural addiction 40 9.65 11 163106 62 110426120
Anterior chamber cell 39.96 9.65 24 163093 1197 110424985
Gastrooesophageal reflux disease 39.91 9.65 134 162983 179842 110246340
Infusion site swelling 39.50 9.65 60 163057 9817 110416365
Infusion site bruising 39.33 9.65 37 163080 3657 110422525
X-ray abnormal 39.13 9.65 5 163112 38112 110388070
Systemic toxicity 38.94 9.65 16 163101 346 110425836
Hypopyon 38.77 9.65 25 163092 1415 110424767
Product administration error 38.73 9.65 132 162985 37085 110389097
Haemoglobin decreased 38.68 9.65 212 162905 248515 110177667
Meningitis chemical 38.60 9.65 16 163101 354 110425828
Retinal artery occlusion 38.57 9.65 39 163078 4210 110421972
Amphetamines positive 38.15 9.65 15 163102 288 110425894
Purtscher retinopathy 38.13 9.65 14 163103 221 110425961
Lupus-like syndrome 38.12 9.65 7 163110 40785 110385397
Muscle spasms 38.02 9.65 247 162870 277910 110148272
Type I hypersensitivity 37.93 9.65 47 163070 6346 110419836
Pneumonia 37.90 9.65 994 162123 875720 109550462
Myoclonus 37.88 9.65 121 162996 32877 110393305
Proctalgia 37.70 9.65 69 163048 13153 110413029
Infusion site erythema 37.42 9.65 65 163052 11894 110414288
Hypothermia 37.36 9.65 104 163013 26198 110399984
Retinitis 36.39 9.65 3 163114 32324 110393858
Blood pressure fluctuation 36.35 9.65 34 163083 74790 110351392
Dermatitis contact 36.28 9.65 70 163047 13883 110412299
Paraplegia 35.86 9.65 45 163072 6155 110420027
Aqueous fibrin 35.65 9.65 13 163104 201 110425981
Hip arthroplasty 35.48 9.65 19 163098 55794 110370388
Cough 34.99 9.65 475 162642 461166 109965016
Ophthalmoplegia 34.85 9.65 34 163083 3516 110422666
Foot deformity 34.69 9.65 14 163103 48466 110377716
Accidental exposure to product 34.63 9.65 156 162961 49852 110376330
Injection site reaction 34.07 9.65 49 163068 89021 110337161
Hepatitis 34.00 9.65 50 163067 90004 110336178
Brain death 33.78 9.65 45 163072 6528 110419654
Musculoskeletal pain 33.65 9.65 147 162970 182876 110243306
Blood lactic acid increased 33.60 9.65 73 163044 15748 110410434
Myocardial fibrosis 33.59 9.65 26 163091 1969 110424213
Orthostatic hypotension 33.50 9.65 29 163088 66220 110359962
Lupus vulgaris 33.47 9.65 5 163112 33878 110392304
Blood pressure systolic increased 33.41 9.65 44 163073 82947 110343235
Serotonin syndrome 33.38 9.65 174 162943 58979 110367203
Drug resistance 33.26 9.65 21 163096 56353 110369829
Fear of eating 33.14 9.65 16 163101 512 110425670
Sleep disorder 32.73 9.65 166 162951 198478 110227704
Pupil fixed 32.62 9.65 34 163083 3804 110422378
Alcohol intolerance 32.53 9.65 15 163102 432 110425750
Cytomegalovirus infection 32.51 9.65 20 163097 54424 110371758
Vasoplegia syndrome 32.29 9.65 40 163077 5399 110420783
Muscular weakness 31.78 9.65 225 162892 248243 110177939
Infusion site pruritus 31.63 9.65 38 163079 4970 110421212
Urticaria 31.59 9.65 309 162808 318548 110107634
Agranulocytosis 31.27 9.65 27 163090 61733 110364449
Onychomycosis 31.25 9.65 9 163108 38522 110387660
Areflexia 31.25 9.65 44 163073 6725 110419457
Toxicologic test abnormal 31.08 9.65 21 163096 1286 110424896
Insomnia 31.06 9.65 361 162756 360229 110065953
Tubulointerstitial nephritis 30.97 9.65 21 163096 54263 110371919
Pain 30.92 9.65 1125 161992 953830 109472352
Retinal vasculitis 30.85 9.65 25 163092 2024 110424158
Abdominal pain 30.70 9.65 552 162565 512437 109913745
Analgesic drug level increased 30.08 9.65 33 163084 3913 110422269
Bone marrow failure 29.65 9.65 25 163092 57823 110368359
Tryptase increased 29.48 9.65 18 163099 925 110425257
Coma scale abnormal 29.32 9.65 52 163065 9674 110416508
Infusion site haemorrhage 29.22 9.65 35 163082 4563 110421619
Taste disorder 29.15 9.65 32 163085 65355 110360827
Vitritis 29.07 9.65 27 163090 2626 110423556
Hypoaesthesia oral 29.02 9.65 72 163045 16930 110409252
Glucose tolerance impaired 28.89 9.65 52 163065 9785 110416397
Hypoxic-ischaemic encephalopathy 28.89 9.65 49 163068 8798 110417384
Sciatica 28.76 9.65 58 163059 92341 110333841
Knee arthroplasty 28.72 9.65 32 163085 64916 110361266
Peripheral nerve injury 28.63 9.65 19 163098 1129 110425053
Infusion site extravasation 28.59 9.65 57 163060 11577 110414605
Renal impairment 28.54 9.65 162 162955 188283 110237899
Sensorimotor disorder 28.27 9.65 19 163098 1153 110425029
Appendicolith 28.27 9.65 64 163053 14191 110411991
Pneumocystis jirovecii pneumonia 27.98 9.65 14 163103 42721 110383461
Gastrointestinal toxicity 27.86 9.65 55 163062 11093 110415089
Septic shock 27.48 9.65 129 162988 157399 110268783
Dizziness 27.46 9.65 802 162315 697391 109728791
Postoperative delirium 27.42 9.65 17 163100 898 110425284
Analgesic therapy 27.38 9.65 43 163074 7241 110418941
Cardiotoxicity 27.26 9.65 70 163047 16811 110409371
Liver injury 26.93 9.65 122 162995 150291 110275891
C-reactive protein 26.69 9.65 6 163111 30325 110395857
Hypercalcaemia 26.69 9.65 18 163099 46639 110379543
Spinal epidural haemorrhage 26.67 9.65 12 163105 326 110425856
Anxiety 26.64 9.65 682 162435 344396 110081786
Pneumonia aspiration 26.57 9.65 208 162909 81025 110345157
Surgery 26.53 9.65 126 162991 41157 110385025
Product use issue 26.47 9.65 313 162804 311382 110114800
Multiple organ dysfunction syndrome 26.46 9.65 341 162776 151369 110274813
Drug therapy 25.98 9.65 42 163075 7249 110418933
Oculocardiac reflex 25.76 9.65 9 163108 122 110426060
Gait disturbance 25.74 9.65 274 162843 277934 110148248
Disease recurrence 25.74 9.65 31 163086 60753 110365429
Mastoiditis 25.62 9.65 25 163092 2586 110423596
Epilepsy 25.51 9.65 70 163047 100139 110326043
Hyperphosphataemia 25.50 9.65 67 163050 16314 110409868
Premature delivery 25.44 9.65 101 163016 30531 110395651
Respiratory tract infection bacterial 25.34 9.65 24 163093 2392 110423790
Postmortem blood drug level increased 25.29 9.65 18 163099 1199 110424983
Stress 25.26 9.65 252 162865 105096 110321086
Chemical burn 25.25 9.65 15 163102 733 110425449
Laboratory test abnormal 25.22 9.65 17 163100 44062 110382120
Sleep disorder therapy 25.22 9.65 42 163075 7429 110418753
Delirium tremens 25.20 9.65 15 163102 736 110425446
Pneumocephalus 25.09 9.65 13 163104 485 110425697
Corneal epithelium defect 24.96 9.65 16 163101 896 110425286
Back injury 24.89 9.65 20 163097 47379 110378803
Anal sphincter atony 24.68 9.65 13 163104 502 110425680
Dry mouth 24.63 9.65 183 162934 199765 110226417
Paralysis 24.49 9.65 64 163053 15536 110410646
Somnambulism 24.34 9.65 38 163079 6367 110419815
Abnormal behaviour 24.26 9.65 118 162999 38921 110387261
Rectal haemorrhage 24.05 9.65 93 163024 119740 110306442
Psychomotor hyperactivity 23.87 9.65 75 163042 20202 110405980
Anaphylactoid shock 23.82 9.65 16 163101 970 110425212
Spinal epidural haematoma 23.78 9.65 20 163097 1705 110424477
Paraesthesia 23.74 9.65 277 162840 276244 110149938
Macular ischaemia 23.73 9.65 10 163107 231 110425951
Blood phosphorus increased 23.60 9.65 65 163052 16275 110409907
Stridor 23.59 9.65 39 163078 6856 110419326
Full blood count abnormal 23.30 9.65 29 163088 56023 110370159
Dehydration 23.23 9.65 282 162835 279229 110146953
Delayed recovery from anaesthesia 23.23 9.65 22 163095 2193 110423989
Migraine 23.15 9.65 153 162964 171499 110254683
Protein C increased 23.03 9.65 7 163110 59 110426123
Breast cancer stage II 22.94 9.65 6 163111 27369 110398813
Osteoporosis 22.85 9.65 60 163057 87092 110339090
Chest pain 22.82 9.65 404 162713 375971 110050211
Neuromuscular blockade 22.74 9.65 14 163103 730 110425452
Hyperaesthesia 22.69 9.65 60 163057 14667 110411515
Myocardial infarction 22.62 9.65 178 162939 191905 110234277
Metastases to liver 22.56 9.65 12 163105 35374 110390808
Melaena 22.40 9.65 42 163075 68715 110357467
Spinal anaesthesia 22.35 9.65 8 163109 117 110426065
Poor quality sleep 22.06 9.65 91 163026 27986 110398196
Tremor 22.06 9.65 420 162697 201812 110224370
Hyperlipidaemia 22.02 9.65 108 163009 35740 110390442
Vocal cord dysfunction 21.96 9.65 15 163102 935 110425247
Arthritis bacterial 21.93 9.65 49 163068 10771 110415411
Brain injury 21.89 9.65 56 163061 13420 110412762
Infusion site mass 21.72 9.65 19 163098 1709 110424473
Platelet aggregation inhibition 21.63 9.65 9 163108 201 110425981
Kidney congestion 21.58 9.65 12 163105 517 110425665
Trigeminal palsy 21.53 9.65 7 163110 75 110426107
Epidural haemorrhage 21.44 9.65 11 163106 402 110425780
Bundle branch block left 21.39 9.65 54 163063 12834 110413348
Congestive hepatopathy 21.29 9.65 32 163085 5188 110420994
Respiratory distress 21.24 9.65 174 162943 68700 110357482
Negative pressure pulmonary oedema 20.98 9.65 13 163104 686 110425496
Substance use 20.94 9.65 22 163095 2484 110423698
Diabetes insipidus 20.94 9.65 36 163081 6534 110419648
Prostate cancer 20.89 9.65 15 163102 37626 110388556
Peritonitis 20.87 9.65 11 163106 32596 110393586
Haemorrhoids 20.87 9.65 106 163011 35566 110390616
Gastroenteritis 20.84 9.65 16 163101 38784 110387398
Medical device site cellulitis 20.81 9.65 9 163108 222 110425960
Ventricular arrhythmia 20.80 9.65 46 163071 10041 110416141
Ventricular extrasystoles 20.73 9.65 77 163040 22564 110403618
Post procedural complication 20.63 9.65 86 163031 26572 110399610
Gastrointestinal haemorrhage 20.62 9.65 151 162966 165367 110260815
Alcoholic coma 20.52 9.65 7 163110 88 110426094
Neuromuscular block prolonged 20.45 9.65 16 163101 1231 110424951
Hyperkalaemia 20.42 9.65 117 163000 135679 110290503
Bursitis infective 20.12 9.65 17 163100 1459 110424723
Therapy cessation 20.07 9.65 124 162993 44733 110381449
Incorrect drug administration rate 19.99 9.65 32 163085 5476 110420706
Torsade de pointes 19.98 9.65 76 163041 22524 110403658
Substance abuser 19.95 9.65 11 163106 466 110425716
Exostosis 19.93 9.65 23 163094 45933 110380249
Pupillary reflex impaired 19.89 9.65 27 163090 3988 110422194
Epidural analgesia 19.82 9.65 8 163109 165 110426017
Seasonal allergy 19.69 9.65 69 163048 19653 110406529
Mean arterial pressure decreased 19.65 9.65 11 163106 480 110425702
Cholestasis 19.65 9.65 41 163076 64477 110361705
Drug tolerance decreased 19.63 9.65 8 163109 27532 110398650
White blood cell count decreased 19.60 9.65 230 162887 229160 110197022
Anaesthetic complication pulmonary 19.60 9.65 8 163109 170 110426012
Myasthenia gravis 19.56 9.65 73 163044 21438 110404744
Product preparation error 19.56 9.65 47 163070 10832 110415350
Procedure aborted 19.47 9.65 8 163109 173 110426009
Airway peak pressure increased 19.37 9.65 12 163105 633 110425549
Oedema 19.34 9.65 207 162910 209769 110216413
Accidental poisoning 19.31 9.65 21 163096 2466 110423716
Hypertonia 19.25 9.65 40 163077 8366 110417816
Acute pulmonary oedema 19.22 9.65 62 163055 16934 110409248
Hypoventilation 19.15 9.65 39 163078 8042 110418140
Diabetes mellitus inadequate control 19.12 9.65 10 163107 29765 110396417
Upper airway obstruction 19.09 9.65 18 163099 1784 110424398
Central pain syndrome 19.08 9.65 13 163104 807 110425375
Encephalopathy 19.00 9.65 193 162924 80862 110345320
Glossoptosis 19.00 9.65 9 163108 276 110425906
Adjustment disorder with depressed mood 18.99 9.65 22 163095 43861 110382321
Haematotoxicity 18.90 9.65 4 163113 21078 110405104
Alcoholic pancreatitis 18.89 9.65 8 163109 187 110425995
Product prescribing error 18.89 9.65 29 163088 51302 110374880
Foetal heart rate abnormal 18.87 9.65 12 163105 663 110425519
Multiple sclerosis relapse 18.86 9.65 28 163089 50212 110375970
Otitis media 18.82 9.65 37 163080 7439 110418743
Pulmonary congestion 18.81 9.65 93 163024 30873 110395309
Ventricular tachyarrhythmia 18.81 9.65 11 163106 522 110425660
Autoimmune disorder 18.80 9.65 43 163074 65440 110360742
Punctate keratitis 18.78 9.65 15 163102 1189 110424993
Parophthalmia 18.75 9.65 11 163106 525 110425657
Infusion site urticaria 18.65 9.65 15 163102 1201 110424981
Finger deformity 18.62 9.65 13 163104 33079 110393103
Anticholinergic syndrome 18.55 9.65 27 163090 4253 110421929
Thrombotic microangiopathy 18.41 9.65 10 163107 29139 110397043
Piloerection 18.40 9.65 13 163104 856 110425326
Medical device site abscess 18.32 9.65 8 163109 202 110425980
Nerve root injury 18.31 9.65 6 163111 66 110426116
Diabetic ketoacidosis 18.29 9.65 21 163096 42037 110384145
Liver function test increased 18.24 9.65 68 163049 88480 110337702
Bezoar 18.19 9.65 26 163091 4028 110422154
Progressive multifocal leukoencephalopathy 18.19 9.65 7 163110 24949 110401233
Drug eruption 18.18 9.65 32 163085 53627 110372555
Lung neoplasm malignant 18.12 9.65 14 163103 33828 110392354
Substance dependence 18.08 9.65 12 163105 713 110425469
Porphyria acute 18.03 9.65 3 163114 18777 110407405
Bladder cancer 17.88 9.65 4 163113 20288 110405894
Spinal meningeal cyst 17.87 9.65 7 163110 133 110426049
Tracheitis 17.87 9.65 17 163100 1704 110424478
Product contamination microbial 17.86 9.65 14 163103 1080 110425102
Osteonecrosis of jaw 17.79 9.65 27 163090 47990 110378192
Upper gastrointestinal haemorrhage 17.77 9.65 29 163088 50067 110376115
Inadequate analgesia 17.75 9.65 29 163088 5048 110421134
Deep vein thrombosis 17.72 9.65 127 162990 139760 110286422
Acute hepatic failure 17.71 9.65 103 163014 36365 110389817
Infusion site discharge 17.71 9.65 18 163099 1955 110424227
Bone density decreased 17.67 9.65 58 163059 15984 110410198
Intellectual disability 17.66 9.65 18 163099 1961 110424221
Brachial plexus injury 17.63 9.65 7 163110 138 110426044
Visceral oedema 17.62 9.65 6 163111 75 110426107
Staphylococcal infection 17.59 9.65 169 162948 69775 110356407
Laryngitis 17.57 9.65 22 163095 42389 110383793
Illness 17.55 9.65 192 162925 81979 110344203
Disorientation 17.40 9.65 170 162947 70501 110355681
Incorrect product formulation administered 17.36 9.65 8 163109 230 110425952
Abortion spontaneous 17.34 9.65 15 163102 34267 110391915
Immunodeficiency 17.32 9.65 19 163098 38819 110387363
Retrograde amnesia 17.19 9.65 12 163105 775 110425407
Incoherent 17.11 9.65 38 163079 8320 110417862
Substance-induced mood disorder 17.07 9.65 6 163111 83 110426099
Jaundice 16.92 9.65 39 163078 59197 110366985
Psychiatric disorder prophylaxis 16.90 9.65 5 163112 38 110426144
Apnoeic attack 16.85 9.65 12 163105 800 110425382
Induced abortion failed 16.84 9.65 7 163110 156 110426026
Physical assault 16.75 9.65 16 163101 1612 110424570
Walking aid user 16.74 9.65 8 163109 25067 110401115
Atonic urinary bladder 16.72 9.65 7 163110 159 110426023
Aspiration 16.67 9.65 89 163028 30444 110395738
Vasculitis 16.61 9.65 17 163100 35856 110390326
Dry skin 16.59 9.65 92 163025 107561 110318621
Eczema 16.59 9.65 53 163064 72240 110353942
Food interaction 16.41 9.65 18 163099 2134 110424048
Quadriplegia 16.41 9.65 25 163092 4102 110422080
Sexual abuse 16.34 9.65 8 163109 264 110425918
Pancreatitis acute 16.18 9.65 41 163076 60233 110365949
Postictal state 16.17 9.65 19 163098 2427 110423755
Acidosis 16.14 9.65 71 163046 22460 110403722
Creatinine renal clearance decreased 16.10 9.65 6 163111 21809 110404373
Foreign body in respiratory tract 16.09 9.65 9 163108 392 110425790
Depression 16.08 9.65 351 162766 316984 110109198
Colitis 16.01 9.65 87 163030 102236 110323946
Injection site ulcer 15.99 9.65 12 163105 868 110425314
Uveitis 15.98 9.65 6 163111 21704 110404478
Multiple injuries 15.96 9.65 23 163094 3591 110422591
Pregnancy 15.94 9.65 32 163085 51035 110375147
Painful ejaculation 15.88 9.65 6 163111 103 110426079
Eosinophilia 15.87 9.65 39 163078 57897 110368285
Memory impairment 15.86 9.65 200 162917 196744 110229438
Axillary nerve injury 15.78 9.65 5 163112 49 110426133
Blood creatinine increased 15.77 9.65 183 162934 182706 110243476
Oxygen saturation decreased 15.76 9.65 322 162795 156660 110269522
Therapy partial responder 15.68 9.65 101 163016 36960 110389222
Maternal alcohol use 15.67 9.65 4 163113 16 110426166
Intelligence test abnormal 15.67 9.65 4 163113 16 110426166
Hypophosphataemia 15.65 9.65 93 163024 33089 110393093
Prostatic pain 15.63 9.65 8 163109 291 110425891
Drowning 15.55 9.65 12 163105 905 110425277
Ventricular asystole 15.53 9.65 9 163108 420 110425762
Electrocution 15.48 9.65 4 163113 17 110426165
Lymphopenia 15.46 9.65 22 163095 40148 110386034
Blood pH decreased 15.43 9.65 26 163091 4643 110421539
Fluid retention 15.42 9.65 79 163038 94228 110331954
Confusional state 15.37 9.65 551 162566 468129 109958053
Hyporesponsive to stimuli 15.35 9.65 20 163097 2840 110423342
Gastritis alcoholic 15.29 9.65 4 163113 18 110426164
Mean arterial pressure increased 15.27 9.65 6 163111 115 110426067
Pemphigoid 15.27 9.65 5 163112 19702 110406480
Administration related reaction 15.23 9.65 8 163109 307 110425875
Neuropathy peripheral 15.22 9.65 180 162937 179097 110247085
Brugada syndrome 15.20 9.65 15 163102 1573 110424609
Nasal congestion 15.14 9.65 84 163033 98198 110327984
Sleep disorder due to a general medical condition 15.14 9.65 34 163083 52078 110374104
Suicidal behaviour 15.07 9.65 22 163095 3475 110422707
Myelodysplastic syndrome 14.96 9.65 20 163097 37464 110388718
Brachial artery entrapment syndrome 14.94 9.65 5 163112 59 110426123
Labelled drug-food interaction issue 14.90 9.65 6 163111 123 110426059
Neuroleptic malignant syndrome 14.82 9.65 17 163100 34042 110392140
Procedural complication 14.78 9.65 36 163081 8369 110417813
Intracranial hypotension 14.58 9.65 10 163107 628 110425554
Potentiating drug interaction 14.57 9.65 44 163073 11599 110414583
Seizure like phenomena 14.57 9.65 18 163099 2423 110423759
Brain herniation 14.57 9.65 37 163080 8826 110417356
Lethargy 14.53 9.65 206 162911 93370 110332812
Open globe injury 14.50 9.65 7 163110 224 110425958
Foetal death 14.47 9.65 3 163114 16042 110410140
Cerebral congestion 14.47 9.65 7 163110 225 110425957
Visual acuity reduced 14.43 9.65 89 163028 32084 110394098
Consciousness fluctuating 14.42 9.65 17 163100 2179 110424003
Conjunctival scar 14.40 9.65 8 163109 344 110425838
Cardiac death 14.37 9.65 15 163102 1681 110424501
Alcoholic 14.33 9.65 4 163113 24 110426158
Benzodiazepine drug level therapeutic 14.33 9.65 4 163113 24 110426158
Constipation 14.28 9.65 410 162707 357376 110068806
Injection site atrophy 14.27 9.65 9 163108 490 110425692
Cytopenia 14.26 9.65 14 163103 30102 110396080
Spinal operation 14.24 9.65 42 163075 10930 110415252
Chronic kidney disease 14.18 9.65 61 163056 76230 110349952
Graft versus host disease 14.17 9.65 5 163112 18801 110407381
Gastric disorder 14.14 9.65 17 163100 33340 110392842
Anterior chamber fibrin 13.97 9.65 7 163110 243 110425939
Hepatocellular injury 13.94 9.65 34 163083 50608 110375574
Injection site joint infection 13.91 9.65 5 163112 74 110426108
Device expulsion 13.90 9.65 15 163102 30876 110395306
Environmental exposure 13.75 9.65 8 163109 376 110425806
Nail bed tenderness 13.75 9.65 8 163109 376 110425806
Adverse reaction 13.73 9.65 14 163103 29580 110396602
Ventricular hypokinesia 13.68 9.65 42 163075 11172 110415010
Ear pain 13.68 9.65 37 163080 53189 110372993
Blood pressure systolic abnormal 13.67 9.65 10 163107 24840 110401342
Maternal exposure timing unspecified 13.58 9.65 7 163110 21006 110405176
Left ventricle outflow tract obstruction 13.57 9.65 9 163108 534 110425648
Sinus bradycardia 13.50 9.65 82 163035 29401 110396781
Educational problem 13.50 9.65 9 163108 539 110425643
Skin exfoliation 13.45 9.65 75 163042 87576 110338606
Blood pressure diastolic abnormal 13.42 9.65 11 163106 25804 110400378
Palmar-plantar erythrodysaesthesia syndrome 13.42 9.65 25 163092 41000 110385182
Hepatic function abnormal 13.39 9.65 77 163040 89218 110336964
Angina pectoris 13.38 9.65 47 163070 62248 110363934
Infusion site discomfort 13.38 9.65 15 163102 1822 110424360
Hypoproteinaemia 13.28 9.65 28 163089 5917 110420265
Nerve root injury cervical 13.28 9.65 3 163114 6 110426176
Hallucination, visual 13.27 9.65 102 163015 39503 110386679
Anal skin tags 13.25 9.65 9 163108 556 110425626
Blood pressure decreased 13.23 9.65 241 162876 114850 110311332
Foreign body 13.14 9.65 19 163098 2976 110423206
Long QT syndrome congenital 13.14 9.65 6 163111 169 110426013
Neuralgia 13.13 9.65 119 162998 48359 110377823
Metastases to lung 13.05 9.65 9 163108 23054 110403128
Logorrhoea 13.05 9.65 25 163092 4932 110421250
Patient uncooperative 12.97 9.65 11 163106 949 110425233
Infusion site irritation 12.95 9.65 12 163105 1163 110425019
Accelerated idioventricular rhythm 12.95 9.65 7 163110 285 110425897
Full blood count decreased 12.94 9.65 17 163100 32082 110394100
Coronary artery disease 12.92 9.65 58 163059 71632 110354550
International normalised ratio increased 12.91 9.65 75 163042 86697 110339485
Spinal cord compression 12.91 9.65 32 163085 7520 110418662
End-tidal CO2 decreased 12.86 9.65 5 163112 93 110426089
Syphilis 12.84 9.65 10 163107 764 110425418
Application site alopecia 12.83 9.65 4 163113 37 110426145
Spinal cord injury 12.82 9.65 14 163103 1651 110424531
Eyelid ptosis 12.77 9.65 46 163071 13281 110412901
Device effect incomplete 12.73 9.65 4 163113 38 110426144
Incision site rash 12.73 9.65 4 163113 38 110426144
Catecholamine crisis 12.72 9.65 5 163112 96 110426086
Opisthotonus 12.71 9.65 10 163107 776 110425406
Enterobacter pneumonia 12.69 9.65 9 163108 596 110425586
Dose calculation error 12.66 9.65 8 163109 437 110425745
Euphoric mood 12.63 9.65 35 163082 8792 110417390
Lip haemorrhage 12.59 9.65 13 163104 1439 110424743
Proteinuria 12.55 9.65 25 163092 39993 110386189
Supraventricular extrasystoles 12.55 9.65 33 163084 8040 110418142
Hypothyroidism 12.53 9.65 60 163057 72839 110353343
Reperfusion arrhythmia 12.47 9.65 7 163110 307 110425875
Cardiac failure 12.47 9.65 198 162919 187428 110238754
Inflammatory marker increased 12.46 9.65 3 163114 14466 110411716
Non-cardiogenic pulmonary oedema 12.44 9.65 15 163102 1969 110424213
Self-medication 12.38 9.65 28 163089 6204 110419978
Diffuse large B-cell lymphoma 12.38 9.65 4 163113 15894 110410288
Economic problem 12.34 9.65 22 163095 4109 110422073
Palpitations 12.33 9.65 163 162954 159049 110267133
Multiple allergies 12.33 9.65 43 163074 12220 110413962
Iron deficiency 12.32 9.65 57 163060 18419 110407763
Eyelid contusion 12.30 9.65 5 163112 105 110426077
Respiratory rate decreased 12.30 9.65 28 163089 6230 110419952
Air embolism 12.24 9.65 9 163108 631 110425551
Encephalomalacia 12.22 9.65 13 163104 1489 110424693
Spinal cord oedema 12.14 9.65 8 163109 470 110425712
Fall 12.07 9.65 748 162369 602734 109823448
Exposure via ingestion 12.03 9.65 24 163093 4876 110421306
Drug-induced liver injury 12.03 9.65 116 163001 119951 110306231
Transient ischaemic attack 11.99 9.65 51 163066 63931 110362251
Vitamin D increased 11.99 9.65 10 163107 843 110425339
Implant site bruising 11.97 9.65 7 163110 332 110425850
Hanging 11.96 9.65 6 163111 209 110425973
Vaginal abscess 11.91 9.65 8 163109 485 110425697
Fatty liver alcoholic 11.89 9.65 4 163113 48 110426134
Mucosal inflammation 11.83 9.65 88 163029 96053 110330129
Neoplasm progression 11.79 9.65 52 163065 64543 110361639
Airway complication of anaesthesia 11.70 9.65 9 163108 675 110425507
Laryngospasm 11.63 9.65 23 163094 4645 110421537
Blood pressure diastolic decreased 11.62 9.65 22 163095 35863 110390319
Familial periodic paralysis 11.60 9.65 7 163110 352 110425830
Gun shot wound 11.57 9.65 11 163106 1101 110425081
Contusion 11.57 9.65 259 162858 233102 110193080
Blood pressure immeasurable 11.56 9.65 16 163101 2407 110423775
Repetitive strain injury 11.53 9.65 6 163111 226 110425956
Suspected suicide attempt 11.51 9.65 7 163110 357 110425825
Rash erythematous 11.51 9.65 72 163045 81760 110344422
Abnormal sleep-related event 11.46 9.65 10 163107 896 110425286
Acute respiratory failure 11.41 9.65 165 162952 75095 110351087
Ependymoma 11.39 9.65 5 163112 128 110426054
Eclampsia 11.37 9.65 7 163110 365 110425817
Myopathy 11.37 9.65 12 163105 24948 110401234
Cytomegalovirus viraemia 11.36 9.65 6 163111 17758 110408424
Drug diversion 11.33 9.65 12 163105 1368 110424814
Pulmonary toxicity 11.28 9.65 54 163063 17692 110408490
Heliotrope rash 11.24 9.65 6 163111 238 110425944
Spinal cord ischaemia 11.24 9.65 6 163111 238 110425944
Pancreatic carcinoma 11.13 9.65 4 163113 14868 110411314
Tenderness 11.12 9.65 78 163039 29359 110396823
Drug-disease interaction 11.11 9.65 14 163103 1922 110424260
Appendicitis 11.09 9.65 76 163041 28388 110397794
Dyspnoea exertional 11.09 9.65 99 163018 103961 110322221
Vitreous disorder 11.05 9.65 7 163110 384 110425798
Epstein-Barr virus infection 11.03 9.65 7 163110 18731 110407451
Impaired quality of life 11.02 9.65 79 163038 29938 110396244
Febrile bone marrow aplasia 11.02 9.65 6 163111 17459 110408723
Visual impairment 11.02 9.65 136 162981 134292 110291890
Transplant rejection 10.98 9.65 12 163105 24555 110401627
Oxidative stress 10.96 9.65 4 163113 62 110426120
Acute myeloid leukaemia 10.96 9.65 25 163092 38085 110388097
Hypertension 10.94 9.65 628 162489 509456 109916726
Aspergillus infection 10.92 9.65 13 163104 25603 110400579
Foetal heart rate decreased 10.90 9.65 4 163113 63 110426119
Imprisonment 10.88 9.65 9 163108 750 110425432
Intestinal obstruction 10.88 9.65 41 163076 53186 110372996
Spinal stroke 10.84 9.65 4 163113 64 110426118
Tachypnoea 10.82 9.65 97 163020 39298 110386884
Vascular resistance systemic decreased 10.76 9.65 6 163111 260 110425922
Inappropriate antidiuretic hormone secretion 10.74 9.65 21 163096 33830 110392352
Anaphylactoid reaction 10.71 9.65 28 163089 6798 110419384
Allergy to immunoglobulin therapy 10.69 9.65 5 163112 149 110426033
Vascular stenosis 10.68 9.65 9 163108 769 110425413
Bacteroides infection 10.65 9.65 17 163100 2902 110423280
Harlequin syndrome 10.65 9.65 6 163111 265 110425917
Myokymia 10.62 9.65 5 163112 151 110426031
Infusion site streaking 10.62 9.65 8 163109 582 110425600
Hepatic fibrosis 10.59 9.65 31 163086 8035 110418147
Hepatitis C virus test positive 10.58 9.65 7 163110 414 110425768
Nerve block 10.57 9.65 9 163108 780 110425402
Femoral nerve injury 10.57 9.65 4 163113 69 110426113
Poor quality product administered 10.53 9.65 22 163095 4619 110421563
Basal cell carcinoma 10.52 9.65 33 163084 45237 110380945
Platelet count decreased 10.52 9.65 259 162858 230184 110195998
Blood methaemoglobin present 10.50 9.65 5 163112 155 110426027
Blood glucose increased 10.50 9.65 135 162982 132361 110293821
Hallucination, tactile 10.49 9.65 10 163107 1005 110425177
Corneal opacity 10.48 9.65 11 163106 1240 110424942
Infusion site rash 10.48 9.65 15 163102 2328 110423854
Respiratory tract infection 10.46 9.65 156 162961 71461 110354721
Feeling hot 10.46 9.65 85 163032 91021 110335161
Chronic sinusitis 10.40 9.65 13 163104 25071 110401111
Temperature regulation disorder 10.39 9.65 3 163114 12823 110413359
Cholestasis of pregnancy 10.38 9.65 11 163106 1254 110424928
Body dysmorphic disorder 10.37 9.65 7 163110 428 110425754
Metastases to bone 10.36 9.65 19 163098 31353 110394829
Panniculitis 10.36 9.65 5 163112 15577 110410605
Dextrocardia 10.35 9.65 3 163114 21 110426161
Syringomyelia 10.35 9.65 6 163111 280 110425902
Middle insomnia 10.33 9.65 9 163108 20493 110405689
Macular degeneration 10.33 9.65 10 163107 21649 110404533
Product distribution issue 10.33 9.65 21 163096 4325 110421857
Second primary malignancy 10.29 9.65 7 163110 18061 110408121
Abdominal pain lower 10.29 9.65 25 163092 37258 110388924
Nervous system disorder 10.25 9.65 81 163036 31640 110394542
Administration site pain 10.17 9.65 9 163108 822 110425360
Injection site bruising 10.15 9.65 40 163077 51223 110374959
Respiratory tract infection viral 10.15 9.65 25 163092 5853 110420329
Arterial injury 10.14 9.65 9 163108 825 110425357
Injection site inflammation 10.11 9.65 22 163095 4749 110421433
Distributive shock 10.07 9.65 25 163092 5879 110420303
Irregular breathing 10.03 9.65 8 163109 633 110425549
Sensory loss 10.03 9.65 60 163057 21397 110404785
Lymphoma 9.99 9.65 9 163108 20162 110406020
Tuberculosis 9.97 9.65 7 163110 17767 110408415
Neoplasm malignant 9.97 9.65 91 163026 37052 110389130
Enterocolitis 9.94 9.65 8 163109 18941 110407241
Amaurosis 9.94 9.65 12 163105 1577 110424605
Intentional dose omission 9.94 9.65 57 163060 20023 110406159
Stab wound 9.90 9.65 6 163111 304 110425878
Hypogammaglobulinaemia 9.89 9.65 9 163108 20067 110406115
Procedural anxiety 9.89 9.65 9 163108 852 110425330
Chemical poisoning 9.89 9.65 5 163112 177 110426005
Anal ulcer 9.88 9.65 13 163104 1863 110424319
Angina unstable 9.86 9.65 6 163111 16426 110409756
Photosensitivity reaction 9.86 9.65 14 163103 25575 110400607
Hepatitis alcoholic 9.86 9.65 8 163109 649 110425533
Attention deficit hyperactivity disorder 9.86 9.65 21 163096 4470 110421712
Premature baby 9.85 9.65 22 163095 4833 110421349
Nasal mucosal disorder 9.84 9.65 13 163104 1870 110424312
Neutropenic sepsis 9.82 9.65 19 163098 30727 110395455
Nasal flaring 9.80 9.65 4 163113 85 110426097
Oxygen therapy 9.79 9.65 20 163097 4133 110422049
Toxic leukoencephalopathy 9.77 9.65 12 163105 1605 110424577
Skin lesion 9.77 9.65 41 163076 51590 110374592
Orbital infection 9.71 9.65 5 163112 184 110425998
Pulmonary haemorrhage 9.70 9.65 49 163068 16407 110409775
Infusion site inflammation 9.68 9.65 7 163110 478 110425704
Haemophagocytic lymphohistiocytosis 9.66 9.65 20 163097 31539 110394643

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 35.96 34.40 10 73 139 113731

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA05 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D09AA11 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA16 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
CHEBI has role CHEBI:27780 detergent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:48219 disinfectant
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D011310 Preservatives, Pharmaceutical
MeSH PA D013501 Surface-Active Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Uveitis indication 128473001 DOID:13141
Skin irritation indication 367466007
Local anesthesia indication 386761002
Allergic otitis externa indication 405821001
Itching of skin indication 418363000
Itching of ear indication 699392007
Post-Op Ocular Inflammation indication
Suppression of the Gag Reflex indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Conduction disorder of the heart contraindication 44808001
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018249 VUID
N0000178890 NUI
D00857 KEGG_DRUG
8001-54-5 SECONDARY_CAS_RN
4018249 VANDF
4023321 VANDF
C0005025 UMLSCUI
CHEBI:188978 CHEBI
CHEMBL1187417 ChEMBL_ID
CHEMBL502109 ChEMBL_ID
CHEMBL1907001 ChEMBL_ID
DB11105 DRUGBANK_ID
7N6JUD5X6Y UNII
2330 PUBCHEM_CID
DB13282 DRUGBANK_ID
1311593 RXNORM
4255 MMSL
5003 MMSL
003141 NDDF
005466 NDDF
006369 NDDF
373549009 SNOMEDCT_US
64686009 SNOMEDCT_US
735078001 SNOMEDCT_US
90370005 SNOMEDCT_US
D001548 MESH_DESCRIPTOR_UI
1168 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
HurriCaine One HUMAN OTC DRUG LABEL 2 0283-1024 SPRAY 1.30 mg TOPICAL OTC Monograph Drug 12 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC Monograph Drug 12 sections
Walgreen HUMAN OTC DRUG LABEL 1 0363-0242 SOAP 130 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Nicefresh scent HUMAN OTC DRUG LABEL 1 0363-0554 CLOTH 0.12 g TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.13 g ORAL OTC Monograph Drug 10 sections
PM Toothache Relief HUMAN OTC DRUG LABEL 4 0363-1623 PASTE 0.13 g DENTAL OTC Monograph Drug 8 sections
Antibacterial Lidocaine Wound Gel HUMAN OTC DRUG LABEL 2 0363-1652 GEL 0.13 g TOPICAL OTC Monograph Drug 12 sections
Antibacterial Lidocaine Wound Gel HUMAN OTC DRUG LABEL 2 0363-1652 GEL 0.13 g TOPICAL OTC Monograph Drug 12 sections
First Aid AntisepticWell at Walgreens HUMAN OTC DRUG LABEL 2 0363-3286 SPRAY 0.13 g TOPICAL OTC monograph not final 11 sections
Walgreens Antibacterial Hand Wipes HUMAN OTC DRUG LABEL 1 0363-5189 CLOTH 0.11 g TOPICAL OTC Monograph Drug 9 sections
Walgreens Fresh Scent Antibacterial Hand Wipes HUMAN OTC DRUG LABEL 1 0363-5197 CLOTH 0.11 g TOPICAL OTC Monograph Drug 9 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.13 g ORAL OTC Monograph Drug 9 sections
Walgreen Maximum strength pain relieving cleansing HUMAN OTC DRUG LABEL 2 0363-7020 LIQUID 0.13 g TOPICAL OTC Monograph Drug 14 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0363-7110 LIQUID 1.25 g TOPICAL OTC monograph not final 11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL HUMAN OTC DRUG LABEL 1 0363-7210 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Walgreens ANTIBACTERIAL HAND REFILL HUMAN OTC DRUG LABEL 1 0363-7211 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
STUDIO 35AMBER HUMAN OTC DRUG LABEL 1 0363-7215 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Antiseptic Pain Relieving HUMAN OTC DRUG LABEL 2 0363-7779 SPRAY 0.10 g TOPICAL OTC monograph not final 7 sections
Walgreens HUMAN OTC DRUG LABEL 2 0363-7950 SPRAY 0.13 g TOPICAL OTC Monograph Drug 12 sections
Walgreens Fresh Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9000 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
Walgreens Citrus Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9002 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
Walgreens Max Strength Burn Gel HUMAN OTC DRUG LABEL 2 0363-9654 GEL 13 mg TOPICAL OTC Monograph Drug 13 sections
Walgreens Advanced Wound Wash HUMAN OTC DRUG LABEL 1 0363-9656 LIQUID 1.30 mg TOPICAL OTC Monograph Drug 12 sections
HUMCO Merthiolate HUMAN OTC DRUG LABEL 1 0395-8010 LIQUID 1.30 mg TOPICAL OTC Monograph Drug 13 sections
Merthiolate HUMAN OTC DRUG LABEL 1 0395-9122 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0404-4445 LIQUID 7.49 g TOPICAL OTC monograph not final 11 sections
BZK Towelette HUMAN OTC DRUG LABEL 1 0404-5824 SWAB 0.00 mL TOPICAL OTC monograph not final 8 sections
BZK HUMAN OTC DRUG LABEL 1 0404-6735 LIQUID 0.00 g TOPICAL OTC Monograph Drug 12 sections