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cetylpyridinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 3083 | 7773-52-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 60 | |||
| kinase-selectivity-class | AKT2,AKT3,AXL,CAMK2D,CDK4,EIF2AK3,EPHB4,GRK2,INSR,MAP2K6,MAPK10,MAPK12,MTOR,PDK4,PLK1,PLK2,PLK3,PLK4,PRKCD,PTK2,SIK2,STK33,TEK,TTK | 24 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Streptococcal sepsis | 36.62 | 33.61 | 8 | 764 | 3576 | 90624099 |
| Pseudomonal sepsis | 35.17 | 33.61 | 8 | 764 | 4294 | 90623381 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Streptococcal sepsis | 33.30 | 28.36 | 8 | 1001 | 5064 | 110583226 |
| Varicose vein | 30.81 | 28.36 | 8 | 1001 | 6932 | 110581358 |
| Metastases to lymph nodes | 28.83 | 28.36 | 9 | 1000 | 15023 | 110573267 |
| Pseudomonal sepsis | 28.71 | 28.36 | 8 | 1001 | 9038 | 110579252 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AB53 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | B05CA01 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives |
| ATC | D08AJ03 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds |
| ATC | D09AA07 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
| ATC | R02AA06 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D003902 | Detergents |
| MeSH PA | D013501 | Surface-Active Agents |
| CHEBI has role | CHEBI:35195 | surfactant |
| CHEBI has role | CHEBI:48218 | antiseptic drug |
Related Drugs by ATC class:
A01AB Antiinfectives and antiseptics for local oral treatment 22 drugs
B05CA Antiinfectives 8 drugs
D08AJ Quaternary ammonium compounds 9 drugs
D09AA Medicated dressings with antiinfectives 11 drugs
R02AA Antiseptics 15 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Local anesthesia | indication | 386761002 | |
| Mouth Irritation | indication | ||
| Suppression of the Gag Reflex | indication | ||
| Hypocupremia | contraindication | 19577007 | |
| Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Caspase-2 | Enzyme | EC50 | 4.68 | CHEMBL | |||||
| High affinity choline transporter 1 | Transporter | Ki | 4.49 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019671 | VUID |
| N0000147763 | NUI |
| D07666 | KEGG_DRUG |
| 6004-24-6 | SECONDARY_CAS_RN |
| 4019096 | VANDF |
| 4019671 | VANDF |
| C0007906 | UMLSCUI |
| CHEMBL305906 | ChEMBL_ID |
| CHEMBL2003538 | ChEMBL_ID |
| DB11073 | DRUGBANK_ID |
| D002594 | MESH_DESCRIPTOR_UI |
| 2683 | PUBCHEM_CID |
| 14498 | IUPHAR_LIGAND_ID |
| CUB7JI0JV3 | UNII |
| 2286 | RXNORM |
| 4401 | MMSL |
| 73038 | MMSL |
| 003144 | NDDF |
| 11719000 | SNOMEDCT_US |
| 387043006 | SNOMEDCT_US |
| 395927000 | SNOMEDCT_US |
| CHEBI:32915 | CHEBI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Oral-BAnti-Bacterial | HUMAN OTC DRUG LABEL | 1 | 0041-1420 | LIQUID | 500 ug | DENTAL | OTC monograph not final | 13 sections |
| Parodontax Active Gum Health Clear Mint | HUMAN OTC DRUG LABEL | 1 | 0135-0650 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Parodontax Active Gum Health Mint | HUMAN OTC DRUG LABEL | 1 | 0135-0651 | MOUTHWASH | 70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Parodontax Active Gum Health Daily Mouthwash Breath Freshener | HUMAN OTC DRUG LABEL | 1 | 0135-0652 | LIQUID | 70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Parodontax Gum Strengthen and Protect | HUMAN OTC DRUG LABEL | 1 | 0135-0654 | RINSE | 0.70 mg | ORAL | OTC Monograph Drug | 11 sections |
| Health | HUMAN OTC DRUG LABEL | 1 | 0363-0099 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 13 sections |
| Cetylpyridinium Chloride | HUMAN OTC DRUG LABEL | 1 | 0363-9542 | LIQUID | 0.50 mg | ORAL | OTC Monograph Drug | 12 sections |
| TheraBreath Healthy Gums | HUMAN OTC DRUG LABEL | 1 | 10237-258 | RINSE | 0.01 mg | ORAL | OTC Monograph Drug | 11 sections |
| Therabreath Plaque Control | HUMAN OTC DRUG LABEL | 1 | 10237-259 | RINSE | 0.02 mg | ORAL | OTC Monograph Drug | 11 sections |
| Therabreath Deep Clean Fresh Mint | HUMAN OTC DRUG LABEL | 1 | 10237-261 | RINSE | 20 mg | ORAL | OTC Monograph Drug | 11 sections |
| Antiseptic | HUMAN OTC DRUG LABEL | 1 | 11344-299 | RINSE | 0.70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Antigingivitis/Antiplaque | HUMAN OTC DRUG LABEL | 1 | 11344-900 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Antiseptic | HUMAN OTC DRUG LABEL | 1 | 11673-299 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 13 sections |
| Alcohol Free Antiseptic | HUMAN OTC DRUG LABEL | 1 | 11822-5761 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 12 sections |
| Mint | HUMAN OTC DRUG LABEL | 1 | 21130-299 | MOUTHWASH | 0.70 mg | ORAL | OTC Monograph Drug | 10 sections |
| Roccos Old SchoolPeircing Armor | HUMAN OTC DRUG LABEL | 1 | 24488-011 | SPRAY | 0.03 mL | TOPICAL | OTC monograph not final | 11 sections |
| Killfire mouth freshener | HUMAN OTC DRUG LABEL | 1 | 24765-134 | SPRAY | 0.05 g | ORAL | unapproved drug other | 8 sections |
| AssuredOral Health Fresh Mint | HUMAN OTC DRUG LABEL | 1 | 33992-0320 | RINSE | 0.07 g | ORAL | OTC monograph not final | 11 sections |
| Colgate Total Active Prevention Peppermint | HUMAN OTC DRUG LABEL | 1 | 35000-279 | RINSE | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 11 sections |
| Colgate Total Active Prevention Spearmint | HUMAN OTC DRUG LABEL | 1 | 35000-280 | RINSE | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Colgate Total Active Prevention Gum Health | HUMAN OTC DRUG LABEL | 1 | 35000-281 | RINSE | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Hello Clean Mintwith aloe vera | HUMAN OTC DRUG LABEL | 1 | 35000-510 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Hello Extra Mintywith extra cooling | HUMAN OTC DRUG LABEL | 1 | 35000-511 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 11 sections |
| Hello Peace Out Plaque peace out, plaque antigingivitis | HUMAN OTC DRUG LABEL | 1 | 35000-683 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Hello Peace Out Plaque peace out, plaque antigingivitis | HUMAN OTC DRUG LABEL | 1 | 35000-683 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Hello empower mint | HUMAN OTC DRUG LABEL | 1 | 35000-690 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Hello empower mint | HUMAN OTC DRUG LABEL | 1 | 35000-690 | MOUTHWASH | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Colgate Total Advanced Pro-Shield Peppermint Blast | HUMAN OTC DRUG LABEL | 1 | 35000-720 | RINSE | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Colgate Total Advanced Gum Health Mouthwash | HUMAN OTC DRUG LABEL | 1 | 35000-723 | RINSE | 0.75 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |
| Colgate Total 12 Hr Pro-Shield Spearmint Surge | HUMAN OTC DRUG LABEL | 1 | 35000-731 | RINSE | 15 mg | DENTAL | OTC MONOGRAPH DRUG | 12 sections |