dexamethasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 81 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.980 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 5.152 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 27.416 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 4.416 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 42.180 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 53.280 % Moderate 0.65
herg hERG pIC50 4.353 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 2.065 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 10.544 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 29.420 % Moderate 0.65
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 15.276 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 11.220 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 8.472 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 38.410 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 18.578 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 40.890 % Moderate 0.65
rat-kpuu-brain Rat brain Kpuu 0.067 % High 1
rh-clint Rat hepatocyte intrinsic clearance 15.959 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 74.520 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 26.410 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 422.669 uM Moderate 0.65

Approvals:

DateAgencyCompanyOrphan
Aug. 25, 2021 PMDA NICHI - IKO PHARMACEUTICAL Co., Ltd.
Oct. 30, 1958 FDA
July 26, 2010 EMA AbbVie Deutschland GmbH & Co. KG

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 3104.80 9.60 2085 419467 38743 90168152
Neutropenia 2993.20 9.60 4409 417143 220495 89986400
Neuropathy peripheral 2663.26 9.60 3233 418319 133737 90073158
Febrile neutropenia 2653.72 9.60 3470 418082 154879 90052016
Thrombocytopenia 2147.13 9.60 3638 417914 205087 90001808
Disease progression 1562.34 9.60 2694 418858 153921 90052974
Diarrhoea 1127.90 9.60 7840 413712 931350 89275545
Death 932.94 9.60 4397 417155 452154 89754741
Platelet count decreased 897.60 9.60 1974 419578 134995 90071900
Systemic lupus erythematosus 801.62 9.60 340 421212 361556 89845339
Anaemia 784.79 9.60 3485 418067 349317 89857578
Rheumatoid arthritis 774.33 9.60 359 421193 362255 89844640
Plasma cell myeloma recurrent 765.10 9.60 380 421172 3848 90203047
Off label use 743.02 9.60 8102 413450 1094150 89112745
Pancytopenia 728.37 9.60 1680 419872 118583 90088312
Pemphigus 727.19 9.60 305 421247 326559 89880336
Constipation 700.71 9.60 2870 418682 277525 89929370
Sepsis 690.11 9.60 2120 419432 177694 90029201
Neutrophil count decreased 675.50 9.60 1202 420350 70330 90136565
Contraindicated product administered 666.47 9.60 328 421224 319811 89887084
White blood cell count decreased 656.01 9.60 1986 419566 165123 90041772
Pain 645.94 9.60 2423 419129 993918 89212977
Hand deformity 634.73 9.60 292 421260 296070 89910825
Cytokine release syndrome 633.79 9.60 715 420837 27258 90179637
Cytopenia 624.43 9.60 571 420981 16878 90190017
Pneumonia 621.36 9.60 5076 416476 632983 89573912
Synovitis 581.75 9.60 412 421140 329340 89877555
Arthralgia 575.43 9.60 1788 419764 776734 89430161
Mucosal inflammation 573.47 9.60 991 420561 56634 90150261
Glossodynia 572.98 9.60 398 421154 321381 89885514
Completed suicide 567.84 9.60 25 421527 145033 90061862
Arthropathy 545.91 9.60 539 421013 365703 89841192
Joint swelling 529.36 9.60 958 420594 502342 89704553
Full blood count decreased 510.85 9.60 660 420892 29029 90177866
Therapeutic product effect decreased 507.94 9.60 333 421219 277238 89929657
Abdominal discomfort 506.03 9.60 904 420648 476424 89730471
Pericarditis 499.92 9.60 320 421232 269831 89937064
Leukopenia 487.00 9.60 1291 420261 99419 90107476
Wound 475.97 9.60 425 421127 302555 89904340
Drug hypersensitivity 471.01 9.60 901 420651 462708 89744187
Swelling 465.70 9.60 770 420782 418288 89788607
Plasmacytoma 455.55 9.60 234 421318 2559 90204336
Deep vein thrombosis 453.72 9.60 1185 420367 90435 90116460
Polyneuropathy 447.77 9.60 500 421052 18841 90188054
Anti-cyclic citrullinated peptide antibody positive 438.87 9.60 279 421273 236154 89970741
Psoriatic arthropathy 409.52 9.60 280 421272 228055 89978840
Injection site pain 409.27 9.60 148 421404 173551 90033344
Hepatic enzyme increased 407.09 9.60 656 420896 360080 89846815
Psoriasis 398.80 9.60 98 421454 147656 90059239
Septic shock 392.89 9.60 1065 420487 83095 90123800
Helicobacter infection 391.31 9.60 290 421262 226560 89980335
Thrombosis 380.81 9.60 965 420587 72286 90134609
Neutropenic sepsis 369.72 9.60 439 421113 17691 90189204
Malignant neoplasm progression 367.68 9.60 1214 420338 105656 90101239
Pulmonary embolism 362.50 9.60 1384 420168 129436 90077459
Therapy partial responder 354.41 9.60 474 421078 21569 90185326
Musculoskeletal stiffness 344.20 9.60 529 421023 296003 89910892
Intentional overdose 343.05 9.60 24 421528 93810 90113085
Tumour lysis syndrome 325.18 9.60 326 421226 10826 90196069
Irritable bowel syndrome 324.44 9.60 292 421260 207156 89999739
Impaired healing 317.20 9.60 373 421179 233826 89973069
Flushing 315.87 9.60 1018 420534 87473 90119422
Duodenal ulcer perforation 312.15 9.60 341 421211 220947 89985948
Folliculitis 308.54 9.60 297 421255 204056 90002839
Condition aggravated 300.77 9.60 1587 419965 593958 89612937
Unevaluable event 300.24 9.60 737 420815 54111 90152784
Posterior reversible encephalopathy syndrome 291.89 9.60 435 421117 21904 90184991
Overdose 289.97 9.60 188 421364 157521 90049374
Mobility decreased 287.39 9.60 451 421101 250283 89956612
Muscle injury 275.80 9.60 249 421303 176405 90030490
Plasma cell myeloma refractory 274.84 9.60 122 421430 934 90205961
Treatment failure 273.62 9.60 632 420920 303296 89903599
COVID-19 pneumonia 262.31 9.60 371 421181 17806 90189089
Peripheral sensory neuropathy 259.84 9.60 265 421287 8985 90197910
Fibromyalgia 258.97 9.60 348 421204 205921 90000974
Type 2 diabetes mellitus 257.09 9.60 341 421211 202903 90003992
Anaphylactic shock 249.35 9.60 492 421060 31125 90175770
Pneumocystis jirovecii pneumonia 247.49 9.60 396 421156 21220 90185675
Discomfort 246.48 9.60 571 420981 273764 89933131
Pyrexia 244.42 9.60 4371 417181 656114 89550781
Blister 237.84 9.60 520 421032 254478 89952417
Headache 234.83 9.60 2726 418826 860020 89346875
Suicide attempt 232.88 9.60 36 421516 75363 90131532
Migraine 230.20 9.60 330 421222 190062 90016833
Haematotoxicity 227.19 9.60 286 421266 12249 90194646
Asthenia 225.28 9.60 3609 417943 530142 89676753
Injury 224.17 9.60 357 421195 196992 90009903
Febrile bone marrow aplasia 217.30 9.60 247 421305 9491 90197404
Dehydration 216.00 9.60 1597 419955 192850 90014045
Drug abuse 215.67 9.60 58 421494 82289 90124606
Drug intolerance 215.12 9.60 1212 420340 446379 89760516
Hypercholesterolaemia 214.85 9.60 100 421452 100792 90106103
Osteoarthritis 214.00 9.60 363 421189 195367 90011528
Multiple organ dysfunction syndrome 212.79 9.60 751 420801 67585 90139310
Ill-defined disorder 211.39 9.60 333 421219 184558 90022337
Pneumonitis 211.15 9.60 564 420988 43606 90163289
Rheumatoid factor positive 211.00 9.60 294 421258 171356 90035539
Light chain analysis increased 209.89 9.60 115 421437 1447 90205448
Bone pain 209.44 9.60 700 420852 61283 90145612
Injection site erythema 209.19 9.60 98 421454 98404 90108491
Bone marrow failure 208.10 9.60 462 421090 31759 90175136
Osteonecrosis 206.52 9.60 408 421144 25833 90181062
Respiratory failure 201.72 9.60 1085 420467 117333 90089562
Diffuse large B-cell lymphoma recurrent 200.63 9.60 151 421401 3375 90203520
Plasma cell leukaemia 200.45 9.60 101 421451 1057 90205838
Sinusitis 199.89 9.60 868 420684 342220 89864675
Bronchopulmonary aspergillosis 198.58 9.60 255 421297 11143 90195752
Osteolysis 197.51 9.60 150 421402 3400 90203495
Loss of personal independence in daily activities 197.14 9.60 205 421347 135900 90070995
Sleep disorder 197.14 9.60 389 421163 197641 90009254
Hyperglycaemia 196.21 9.60 602 420950 50368 90156527
Joint range of motion decreased 195.69 9.60 205 421347 135438 90071457
Alopecia 193.82 9.60 1427 420125 493644 89713251
Haemophagocytic lymphohistiocytosis 187.77 9.60 291 421261 15168 90191727
Depression 187.24 9.60 741 420811 299860 89907035
Maternal exposure during pregnancy 186.79 9.60 950 420602 359113 89847782
Laboratory test abnormal 186.67 9.60 521 421031 41333 90165562
Injection site reaction 185.90 9.60 98 421454 91982 90114913
Immune effector cell-associated neurotoxicity syndrome 185.68 9.60 178 421374 5590 90201305
Drug ineffective 185.64 9.60 4966 416586 1379332 88827563
Asthma 182.52 9.60 550 421002 241610 89965285
Fatigue 178.00 9.60 6798 414754 1147225 89059670
Neurotoxicity 174.06 9.60 338 421214 21129 90185766
Metastases to central nervous system 170.95 9.60 299 421253 17243 90189652
Endophthalmitis 170.91 9.60 155 421397 4530 90202365
Product use issue 167.98 9.60 876 420676 329043 89877852
Wheezing 167.31 9.60 558 420994 237522 89969373
Cytomegalovirus infection 166.82 9.60 377 421175 26225 90180670
Rheumatic fever 163.68 9.60 288 421264 152833 90054062
Sleep disorder due to general medical condition, insomnia type 162.61 9.60 216 421336 128478 90078417
Arthritis 161.95 9.60 334 421218 166981 90039914
Myelodysplastic syndrome 160.88 9.60 322 421230 20581 90186314
Hypokalaemia 158.95 9.60 1100 420452 130016 90076879
Drug ineffective for unapproved indication 158.86 9.60 673 420879 65971 90140924
Lymphopenia 156.77 9.60 336 421216 22545 90184350
Venoocclusive liver disease 156.30 9.60 165 421387 5828 90201067
Abortion spontaneous 153.53 9.60 32 421520 54024 90152871
Blood cholesterol increased 152.07 9.60 479 421073 207533 89999362
Weight increased 151.58 9.60 1230 420322 416697 89790198
Multiple sclerosis relapse 148.48 9.60 31 421521 52274 90154621
Hypogammaglobulinaemia 148.33 9.60 214 421338 10460 90196435
Cytomegalovirus infection reactivation 147.82 9.60 182 421370 7618 90199277
Dysgeusia 147.07 9.60 558 420994 52002 90154893
Mucormycosis 146.47 9.60 130 421422 3691 90203204
Therapeutic product effect incomplete 146.35 9.60 440 421112 193456 90013439
Hepatitis B reactivation 145.99 9.60 132 421420 3842 90203053
Nausea 144.54 9.60 6425 415127 1103891 89103004
Facet joint syndrome 139.33 9.60 151 421401 98238 90108657
Liver injury 137.57 9.60 375 421177 170192 90036703
Acute lymphocytic leukaemia recurrent 136.22 9.60 108 421444 2613 90204282
Pain in extremity 135.96 9.60 1389 420163 449140 89757755
Renal failure 133.12 9.60 1054 420498 129953 90076942
Myelosuppression 133.05 9.60 548 421004 53043 90153852
Premature delivery 132.04 9.60 439 421113 38323 90168572
Knee arthroplasty 131.27 9.60 116 421436 83066 90123829
Inflammation 130.70 9.60 411 421141 178181 90028714
Obesity 130.33 9.60 180 421372 105327 90101568
Injection site pruritus 129.95 9.60 44 421508 53790 90153105
Bursitis 129.79 9.60 260 421292 131394 90075501
Product quality issue 129.60 9.60 107 421445 79218 90127677
COVID-19 129.43 9.60 1277 420275 167566 90039329
Coeliac disease 127.54 9.60 26 421526 44584 90162311
Intentional product misuse 127.45 9.60 137 421415 89467 90117428
Injection site bruising 125.83 9.60 43 421509 52264 90154631
Injection site swelling 124.80 9.60 61 421491 59778 90147117
Breast cancer stage III 124.76 9.60 125 421427 84322 90122573
Bronchospasm 121.61 9.60 286 421266 20423 90186472
Foot deformity 121.12 9.60 63 421489 59588 90147307
Aspergillus infection 120.78 9.60 196 421356 10627 90196268
Colitis ulcerative 120.38 9.60 65 421487 60201 90146694
Hypertriglyceridaemia 119.76 9.60 165 421387 7724 90199171
Acute lymphocytic leukaemia 119.46 9.60 102 421450 2746 90204149
Back pain 119.00 9.60 2105 419447 315070 89891825
Urticaria 118.62 9.60 909 420643 311825 89895070
Grip strength decreased 118.35 9.60 154 421398 92422 90114473
Suicidal ideation 117.74 9.60 102 421450 73753 90133142
Haemoglobin decreased 117.44 9.60 1211 420341 160745 90046150
Escherichia bacteraemia 117.14 9.60 139 421413 5596 90201299
Prescribed overdose 116.19 9.60 171 421381 97454 90109441
Bacteraemia 115.02 9.60 293 421259 22007 90184888
Hypoxia 114.98 9.60 651 420901 71748 90135147
Clostridium difficile colitis 114.74 9.60 328 421224 26378 90180517
Nasopharyngitis 114.36 9.60 1276 420276 405828 89801067
B-cell type acute leukaemia 113.08 9.60 56 421496 563 90206332
Wound infection 107.58 9.60 207 421345 106195 90100700
Neoplasm progression 106.60 9.60 450 421102 44036 90162859
Systemic candida 105.96 9.60 123 421429 4836 90202059
Stress 104.46 9.60 135 421417 81260 90125635
Gait disturbance 103.13 9.60 748 420804 259748 89947147
Lower respiratory tract infection 103.02 9.60 712 420840 249947 89956948
Candida infection 102.34 9.60 370 421182 33687 90173208
Diffuse large B-cell lymphoma refractory 102.23 9.60 77 421475 1723 90205172
Cardiac amyloidosis 101.21 9.60 62 421490 974 90205921
Intentional self-injury 100.33 9.60 10 421542 29324 90177571
Ejection fraction decreased 100.03 9.60 309 421243 25944 90180951
Pathological fracture 99.83 9.60 169 421383 9491 90197404
Accidental exposure to product 96.55 9.60 38 421514 42328 90164567
Joint stiffness 95.53 9.60 134 421418 77908 90128987
Decreased appetite 95.09 9.60 2358 419194 374182 89832713
Bone marrow disorder 94.65 9.60 92 421460 2940 90203955
Disease recurrence 93.44 9.60 385 421167 37268 90169627
Rhinocerebral mucormycosis 93.42 9.60 54 421498 758 90206137
Palmar-plantar erythrodysaesthesia syndrome 93.34 9.60 315 421237 27708 90179187
Bone erosion 92.35 9.60 67 421485 52954 90153941
Ageusia 92.21 9.60 220 421332 15856 90191039
Gastrooesophageal reflux disease 90.67 9.60 431 421121 165906 90040989
Finger deformity 90.33 9.60 21 421531 32876 90174019
Corneal decompensation 90.12 9.60 26 421526 39 90206856
Corneal oedema 89.94 9.60 73 421479 1828 90205067
Acute kidney injury 89.61 9.60 2035 419517 318352 89888543
Rhinovirus infection 89.44 9.60 124 421428 5839 90201056
Blood potassium decreased 89.31 9.60 449 421103 47278 90159617
Monoclonal immunoglobulin present 88.94 9.60 76 421476 2048 90204847
Muscle spasticity 88.56 9.60 27 421525 35295 90171600
Red blood cell sedimentation rate increased 88.55 9.60 155 421397 82440 90124455
Frequent bowel movements 87.91 9.60 81 421471 56854 90150041
Swollen joint count increased 87.78 9.60 247 421305 110959 90095936
Hip arthroplasty 86.34 9.60 138 421414 76070 90130825
Osteoporosis 85.73 9.60 202 421350 96329 90110566
Thrombotic microangiopathy 85.55 9.60 211 421341 15532 90191363
Aplastic anaemia 85.38 9.60 190 421362 13079 90193816
Large intestine perforation 85.02 9.60 158 421394 9554 90197341
Atrial fibrillation 84.80 9.60 973 420579 132638 90074257
Stem cell transplant 83.99 9.60 74 421478 2080 90204815
Pulmonary fibrosis 83.95 9.60 240 421312 107263 90099632
Wrong technique in product usage process 83.57 9.60 127 421425 71444 90135451
Hospitalisation 83.39 9.60 310 421242 127790 90079105
Surgery 83.15 9.60 53 421499 44834 90162061
Incorrect dose administered 82.93 9.60 150 421402 78780 90128115
Lupus-like syndrome 82.15 9.60 64 421488 48782 90158113
Blepharospasm 81.98 9.60 82 421470 55363 90151532
Erythema 81.18 9.60 1508 420044 227738 89979157
Neutrophil count abnormal 80.95 9.60 98 421454 4030 90202865
Pleural effusion 80.02 9.60 835 420717 111156 90095739
Onychomycosis 79.63 9.60 37 421515 37339 90169556
Pneumonia fungal 79.37 9.60 128 421424 6903 90199992
Peripheral venous disease 79.10 9.60 170 421382 83751 90123144
Food allergy 79.04 9.60 12 421540 25466 90181429
Strongyloidiasis 78.94 9.60 63 421489 1539 90205356
Febrile infection 78.53 9.60 70 421482 1999 90204896
Vasogenic cerebral oedema 77.32 9.60 57 421495 1233 90205662
Macular degeneration 77.23 9.60 40 421512 37930 90168965
Neutropenic colitis 75.83 9.60 95 421457 4048 90202847
Exostosis 75.82 9.60 81 421471 53053 90153842
Disseminated intravascular coagulation 75.20 9.60 246 421306 21292 90185603
Acute respiratory distress syndrome 74.91 9.60 298 421254 28388 90178507
Cytomegalovirus chorioretinitis 74.76 9.60 73 421479 2346 90204549
Inappropriate schedule of product administration 74.59 9.60 401 421151 149532 90057363
Pulmonary thrombosis 74.45 9.60 150 421402 9632 90197263
Joint dislocation 74.24 9.60 59 421493 44523 90162372
Ocular hypertension 74.23 9.60 62 421490 1618 90205277
Pneumonia influenzal 73.76 9.60 70 421482 2170 90204725
Back injury 72.37 9.60 66 421486 46556 90160339
Sleep disorder due to a general medical condition 72.27 9.60 61 421491 44677 90162218
Aplasia 72.23 9.60 91 421461 3900 90202995
Hepatic cirrhosis 72.17 9.60 114 421438 63139 90143756
Bone lesion 71.06 9.60 116 421436 6321 90200574
Blood lactate dehydrogenase increased 70.64 9.60 273 421279 25659 90181236
Dislocation of vertebra 70.61 9.60 94 421458 55874 90151021
Embolism 70.51 9.60 144 421408 9337 90197558
Eastern Cooperative Oncology Group performance status worsened 70.43 9.60 64 421488 1875 90205020
Musculoskeletal pain 69.56 9.60 488 421064 170763 90036132
Hypocalcaemia 68.60 9.60 383 421169 41985 90164910
Neutropenic infection 68.25 9.60 61 421491 1748 90205147
Contusion 67.88 9.60 794 420758 250422 89956473
Hypofibrinogenaemia 67.77 9.60 54 421498 1316 90205579
Cardiac failure 67.08 9.60 792 420760 108704 90098191
Fall 67.04 9.60 1717 419835 480093 89726802
Hypercalcaemia 66.82 9.60 326 421226 33914 90172981
Brain oedema 66.58 9.60 205 421347 17180 90189715
Dyspnoea 66.37 9.60 4853 416699 876102 89330793
C-reactive protein abnormal 66.08 9.60 336 421216 127093 90079802
Blood pressure systolic increased 65.77 9.60 106 421446 58239 90148656
Substance-induced psychotic disorder 65.21 9.60 74 421478 2838 90204057
Respiratory syncytial virus infection 65.12 9.60 148 421404 10332 90196563
Herpes simplex encephalitis 64.85 9.60 34 421518 389 90206506
Pneumatosis intestinalis 64.81 9.60 80 421472 3357 90203538
Gait inability 64.68 9.60 407 421145 146049 90060846
Lip dry 64.60 9.60 246 421306 100709 90106186
Osteonecrosis of jaw 64.32 9.60 355 421197 38748 90168147
Blood pressure fluctuation 64.14 9.60 90 421462 52323 90154572
Sleep apnoea syndrome 63.75 9.60 34 421518 31713 90175182
Drug withdrawal syndrome 63.44 9.60 27 421525 28696 90178199
Anaphylactic reaction 63.19 9.60 654 420898 86870 90120025
Intraocular pressure increased 62.85 9.60 116 421436 6977 90199918
Computerised tomogram thorax abnormal 62.67 9.60 62 421490 2025 90204870
Eczema 62.52 9.60 93 421459 52777 90154118
Brain abscess 62.19 9.60 71 421481 2741 90204154
Swelling face 62.15 9.60 615 420937 80737 90126158
Clostridium difficile infection 61.61 9.60 332 421220 35913 90170982
Paraproteinaemia 61.50 9.60 28 421524 229 90206666
C-reactive protein increased 61.08 9.60 544 421008 180845 90026050
Colitis 60.55 9.60 543 421009 69399 90137496
Hypersensitivity 60.42 9.60 1631 419921 453046 89753849
Tremor 60.39 9.60 1025 420527 152148 90054747
Injection site haemorrhage 60.38 9.60 28 421524 28290 90178605
Breast cancer metastatic 60.36 9.60 181 421371 14951 90191944
Premature baby 60.33 9.60 254 421298 24823 90182072
Acute myeloid leukaemia 60.12 9.60 222 421330 20418 90186477
Venous thrombosis 60.06 9.60 99 421453 5438 90201457
Therapy non-responder 59.93 9.60 931 420621 135773 90071122
Pseudomonal sepsis 59.41 9.60 86 421466 4216 90202679
Onychomadesis 59.32 9.60 76 421476 45922 90160973
Prescribed underdose 58.92 9.60 167 421385 74852 90132043
Laryngospasm 58.74 9.60 75 421477 3258 90203637
Cataract 58.52 9.60 552 421000 71540 90135355
Product label confusion 58.14 9.60 17 421535 22833 90184062
Blood pressure diastolic abnormal 58.06 9.60 11 421541 19870 90187025
Red blood cell sedimentation rate abnormal 58.03 9.60 20 421532 24184 90182711
Impaired work ability 57.94 9.60 10 421542 19316 90187579
Lupus vulgaris 57.54 9.60 75 421477 44984 90161911
Intestinal perforation 57.23 9.60 168 421384 13713 90193182
Pruritus 57.17 9.60 2003 419549 539522 89667373
Human chorionic gonadotropin increased 56.94 9.60 57 421495 1889 90205006
Ileus 56.88 9.60 188 421364 16358 90190537
Dysphonia 56.28 9.60 493 421059 62591 90144304
Infusion related reaction 56.17 9.60 1492 420060 415288 89791607
Brain stem glioma 56.00 9.60 24 421528 167 90206728
Gastrointestinal disorder 55.62 9.60 849 420703 255838 89951057
Epistaxis 55.39 9.60 623 420929 84502 90122393
Computerised tomogram thorax 55.37 9.60 33 421519 492 90206403
Respiratory distress 55.25 9.60 340 421212 38606 90168289
Urinary tract infection 55.20 9.60 1835 419717 303797 89903098
Road traffic accident 55.12 9.60 285 421267 107341 90099554
Hypotension 55.08 9.60 1939 419613 323458 89883437
Injection site warmth 54.91 9.60 8 421544 17507 90189388
Low birth weight baby 54.78 9.60 130 421422 9337 90197558
Peripheral sensorimotor neuropathy 54.57 9.60 57 421495 1988 90204907
Device issue 54.54 9.60 35 421517 29502 90177393
Cryptococcosis 54.31 9.60 49 421503 1422 90205473
Shock 54.03 9.60 271 421281 28507 90178388
Sedation 53.84 9.60 88 421464 48083 90158812
Primary amyloidosis 53.48 9.60 20 421532 92 90206803
Enterocolitis 53.24 9.60 137 421415 10353 90196542
Chronic sinusitis 53.17 9.60 22 421530 23780 90183115
Nasal congestion 52.89 9.60 204 421348 83210 90123685
Pneumonia pneumococcal 52.75 9.60 64 421488 2638 90204257
Leukoencephalopathy 52.69 9.60 87 421465 4786 90202109
Protein total increased 52.68 9.60 73 421479 3436 90203459
Escherichia sepsis 52.65 9.60 96 421456 5720 90201175
Injection site urticaria 52.53 9.60 10 421542 18001 90188894
Temperature regulation disorder 52.50 9.60 4 421548 14575 90192320
Acute respiratory failure 51.93 9.60 360 421192 42558 90164337
Coronary artery disease 51.71 9.60 48 421504 33575 90173320
Confusional state 51.65 9.60 1384 420168 384821 89822074
Weight fluctuation 51.44 9.60 205 421347 19544 90187351
Multiple sclerosis 51.39 9.60 33 421519 27807 90179088
Therapeutic response shortened 51.35 9.60 21 421531 22858 90184037
Pulmonary mucormycosis 51.31 9.60 33 421519 567 90206328
Cardiotoxicity 51.00 9.60 142 421410 11247 90195648
Adjustment disorder with depressed mood 51.00 9.60 118 421434 56635 90150260
Listeriosis 50.90 9.60 51 421501 1692 90205203
Amyloidosis 50.68 9.60 44 421508 1212 90205683
Ascites 50.62 9.60 388 421164 47352 90159543
Iris atrophy 50.58 9.60 20 421532 110 90206785
Nail disorder 50.55 9.60 126 421426 58941 90147954
Coma 50.44 9.60 171 421381 72461 90134434
Propofol infusion syndrome 50.22 9.60 45 421507 1294 90205601
Hyperbilirubinaemia 49.40 9.60 160 421392 13776 90193119
Parainfluenzae virus infection 49.28 9.60 63 421489 2740 90204155
Alanine aminotransferase increased 49.26 9.60 799 420753 117539 90089356
Blood pressure diastolic decreased 49.24 9.60 32 421520 26794 90180101
Hyperviscosity syndrome 49.19 9.60 24 421528 233 90206662
Ankylosing spondylitis 49.05 9.60 3 421549 13130 90193765
Carpal tunnel syndrome 48.98 9.60 25 421527 23903 90182992
Hypoglycaemia 48.81 9.60 164 421388 69684 90137211
Influenza like illness 48.67 9.60 201 421351 80410 90126485
Gastrointestinal toxicity 48.42 9.60 124 421428 9343 90197552
Sedation complication 48.17 9.60 10 421542 16934 90189961
Myocardial infarction 48.08 9.60 292 421260 105680 90101215
Human bocavirus infection 48.04 9.60 29 421523 443 90206452
Myelopathy 47.78 9.60 69 421483 3375 90203520
Vitreous haemorrhage 47.72 9.60 60 421492 2566 90204329
Procedural pain 47.44 9.60 51 421501 33309 90173586
Hypertension 47.42 9.60 1696 419856 455836 89751059
Dermatitis atopic 47.33 9.60 25 421527 23447 90183448
Ear infection 47.29 9.60 166 421386 69609 90137286
Injection site rash 46.93 9.60 27 421525 24146 90182749
Blood pressure systolic abnormal 46.87 9.60 16 421536 19462 90187433
Adrenogenital syndrome 46.60 9.60 15 421537 39 90206856
Exposure during pregnancy 46.52 9.60 804 420748 237606 89969289
Meningitis listeria 46.39 9.60 33 421519 674 90206221
Glioblastoma 46.29 9.60 37 421515 906 90205989
Chills 46.27 9.60 867 420685 131114 90075781
Neck pain 46.14 9.60 325 421227 113638 90093257
Respiratory tract infection 45.80 9.60 448 421104 58630 90148265
Peripheral motor neuropathy 45.65 9.60 51 421501 1922 90204973
Pneumonia parainfluenzae viral 45.42 9.60 26 421526 358 90206537
Throat tightness 45.41 9.60 263 421289 29221 90177674
Atelectasis 45.22 9.60 229 421323 24180 90182715
Product complaint 45.15 9.60 5 421547 13495 90193400
Tenosynovitis 44.87 9.60 7 421545 14560 90192335
Endocarditis 44.81 9.60 101 421451 7012 90199883
Nervous system disorder 44.61 9.60 209 421343 21384 90185511
Stridor 44.51 9.60 80 421472 4713 90202182
Rheumatoid nodule 44.47 9.60 19 421533 20147 90186748
White blood cell count abnormal 44.46 9.60 104 421448 7400 90199495
Pneumomediastinum 44.44 9.60 51 421501 1980 90204915
Spinal cord compression 44.38 9.60 81 421471 4830 90202065
Hyperaemia 44.29 9.60 58 421494 2584 90204311
Chronic obstructive pulmonary disease 44.01 9.60 185 421367 73644 90133251
Mantle cell lymphoma recurrent 43.95 9.60 26 421526 382 90206513
Injection site mass 43.86 9.60 24 421528 22066 90184829
Heart block congenital 43.76 9.60 12 421540 13 90206882
Human herpesvirus 6 infection 43.64 9.60 66 421486 3366 90203529
Epilepsy 43.62 9.60 215 421337 81991 90124904
Proctitis 43.40 9.60 9 421543 15250 90191645
Product storage error 43.17 9.60 20 421532 20221 90186674
Vomiting 43.05 9.60 4240 417312 784053 89422842
B precursor type acute leukaemia 42.71 9.60 22 421530 242 90206653
Dry mouth 42.56 9.60 601 420951 183458 90023437
Disability 42.29 9.60 78 421474 40667 90166228
Seronegative arthritis 42.13 9.60 16 421536 18218 90188677
Electrolyte imbalance 42.06 9.60 220 421332 23525 90183370
Tooth disorder 41.97 9.60 268 421284 30822 90176073
Tracheal deviation 41.79 9.60 22 421530 254 90206641
Alpha haemolytic streptococcal infection 41.72 9.60 46 421506 1708 90205187
Acute generalised exanthematous pustulosis 41.27 9.60 149 421403 13554 90193341
Pneumonia cytomegaloviral 41.24 9.60 61 421491 3050 90203845
Mitochondrial DNA mutation 41.18 9.60 26 421526 432 90206463
Full blood count increased 41.10 9.60 39 421513 1209 90205686
Corneal disorder 40.90 9.60 49 421503 1993 90204902
Monoclonal immunoglobulin increased 40.63 9.60 25 421527 396 90206499
Sopor 40.55 9.60 33 421519 24611 90182284
Performance status decreased 40.47 9.60 72 421480 4208 90202687
Hepatitis E 40.40 9.60 47 421505 1852 90205043
Light chain analysis abnormal 40.37 9.60 19 421533 169 90206726
Cardiopulmonary failure 40.31 9.60 71 421481 4117 90202778
Memory impairment 40.16 9.60 660 420892 196584 90010311
Pustular psoriasis 40.10 9.60 18 421534 18538 90188357
Staphylococcal sepsis 40.07 9.60 115 421437 9268 90197627
Meningitis cryptococcal 40.06 9.60 46 421506 1787 90205108
Pulmonary haemorrhage 40.00 9.60 104 421448 7909 90198986
Diffuse large B-cell lymphoma 39.91 9.60 109 421443 8536 90198359
Herpes simplex 39.87 9.60 121 421431 10060 90196835
Oxygen saturation decreased 39.75 9.60 712 420840 106771 90100124
Haemoglobin abnormal 39.47 9.60 96 421456 7004 90199891
Nocardiosis 39.38 9.60 54 421498 2516 90204379
Pneumonia bacterial 39.31 9.60 140 421412 12650 90194245
Blood lactate dehydrogenase abnormal 39.30 9.60 25 421527 421 90206474
Bone marrow infiltration 39.14 9.60 32 421520 810 90206085
Chest discomfort 38.97 9.60 880 420672 137485 90069410
Bone density decreased 38.80 9.60 16 421536 17329 90189566
Hypoalbuminaemia 38.23 9.60 161 421391 15736 90191159
Lacrimation increased 38.22 9.60 236 421316 26826 90180069
Chorioretinopathy 37.90 9.60 32 421520 848 90206047
Salmonella sepsis 37.80 9.60 21 421531 272 90206623
Bacterial sepsis 37.73 9.60 76 421476 4879 90202016
Secondary immunodeficiency 37.72 9.60 48 421504 2078 90204817
Neoplasm recurrence 37.71 9.60 60 421492 3199 90203696
Enterobacter infection 37.68 9.60 53 421499 2530 90204365
Laryngitis 37.67 9.60 116 421436 50637 90156258
Red blood cell count decreased 37.66 9.60 355 421197 45996 90160899
Adrenal insufficiency 37.40 9.60 253 421299 29668 90177227
Hordeolum 37.36 9.60 75 421477 4803 90202092
Injection site induration 37.33 9.60 3 421549 10465 90196430
Neuroleptic malignant syndrome 37.02 9.60 12 421540 15084 90191811
Circulatory collapse 36.97 9.60 220 421332 24684 90182211
Phrenic nerve paralysis 36.91 9.60 22 421530 328 90206567
Joint effusion 36.88 9.60 23 421529 19687 90187208
Walking aid user 36.82 9.60 68 421484 35438 90171457
Malaise 36.72 9.60 2292 419260 583694 89623201
Hepatotoxicity 36.70 9.60 350 421202 45492 90161403
Cystitis haemorrhagic 36.67 9.60 80 421472 5433 90201462
Infective pulmonary exacerbation of cystic fibrosis 36.51 9.60 3 421549 10276 90196619
Blood culture positive 36.50 9.60 76 421476 4996 90201899
Squamous cell carcinoma of skin 36.49 9.60 96 421456 7353 90199542
Progressive multifocal leukoencephalopathy 36.45 9.60 157 421395 15498 90191397
Adverse reaction 36.37 9.60 51 421501 29661 90177234
Ileus paralytic 36.37 9.60 76 421476 5009 90201886
Enterococcal bacteraemia 36.32 9.60 46 421506 1982 90204913
Retinitis 36.15 9.60 78 421474 38380 90168515
Jugular vein thrombosis 36.15 9.60 62 421490 3519 90203376
Enterococcal sepsis 36.07 9.60 41 421511 1575 90205320
Steroid diabetes 36.00 9.60 51 421501 2451 90204444
Medication error 35.96 9.60 238 421314 84414 90122481
Soft tissue infection 35.83 9.60 55 421497 2842 90204053
Herpes simplex reactivation 35.78 9.60 33 421519 986 90205909
Urosepsis 35.75 9.60 194 421358 21038 90185857
Adverse event 35.74 9.60 361 421191 117057 90089838
Exposure via skin contact 35.71 9.60 4 421548 10701 90196194
Pneumonia viral 35.63 9.60 106 421446 8717 90198178
Phaeochromocytoma crisis 35.62 9.60 22 421530 351 90206544
Meningitis herpes 35.60 9.60 20 421532 265 90206630
JC virus infection 35.59 9.60 53 421499 2666 90204229
Metastases to meninges 35.53 9.60 63 421489 3672 90203223
Night sweats 35.52 9.60 405 421147 128361 90078534
Keratitis fungal 35.51 9.60 18 421534 191 90206704
Palpitations 35.43 9.60 436 421116 136292 90070603
Coombs indirect test positive 35.32 9.60 12 421540 39 90206856
Tachycardia 35.24 9.60 972 420580 156701 90050194
Hyperpyrexia 35.04 9.60 72 421480 4689 90202206
Encephalopathy 34.93 9.60 350 421202 46094 90160801
Female genital tract fistula 34.63 9.60 20 421532 17848 90189047
Sternal fracture 34.58 9.60 54 421498 2833 90204062
Haematochezia 34.52 9.60 191 421361 70722 90136173
Underdose 34.31 9.60 132 421420 53885 90153010
Second primary malignancy 33.98 9.60 116 421436 10262 90196633
Pulmonary oedema 33.69 9.60 439 421113 61641 90145254
Escherichia infection 33.68 9.60 155 421397 15740 90191155
General symptom 33.68 9.60 13 421539 14655 90192240
Acute interstitial pneumonitis 33.67 9.60 29 421523 790 90206105
Rhinitis allergic 33.67 9.60 18 421534 16767 90190128
Platelet count abnormal 33.62 9.60 67 421485 4268 90202627
Enteritis 33.47 9.60 115 421437 10206 90196689
Ulcer haemorrhage 33.41 9.60 44 421508 26277 90180618
Staphylococcal bacteraemia 33.32 9.60 93 421459 7376 90199519
Cholecystectomy 33.29 9.60 7 421545 11748 90195147
International normalised ratio increased 33.12 9.60 111 421441 47205 90159690
Product dose omission in error 33.06 9.60 28 421524 20475 90186420
Drug-induced liver injury 33.03 9.60 265 421287 90053 90116842
Spinal fracture 33.01 9.60 195 421357 21821 90185074
Lactic acidosis 32.90 9.60 122 421430 50341 90156554
Pulmonary sepsis 32.87 9.60 46 421506 2185 90204710
Musculoskeletal chest pain 32.85 9.60 206 421346 23544 90183351
Refractory cytopenia with multilineage dysplasia 32.71 9.60 15 421537 125 90206770
Withdrawal syndrome 32.51 9.60 34 421518 22490 90184405
Perineal necrosis 32.50 9.60 15 421537 127 90206768
Gastrointestinal perforation 32.46 9.60 66 421486 4266 90202629
Hypothalamic pituitary adrenal axis suppression 32.44 9.60 20 421532 318 90206577
Crying 32.42 9.60 43 421509 25602 90181293
Central nervous system leukaemia 32.41 9.60 18 421534 233 90206662
Sciatica 32.40 9.60 308 421244 101074 90105821
Lymphoma 32.18 9.60 137 421415 13454 90193441
Arterial occlusive disease 32.14 9.60 9 421543 12437 90194458
Partial seizures 32.00 9.60 90 421462 7170 90199725
Type I hypersensitivity 31.96 9.60 64 421488 4091 90202804
Renal amyloidosis 31.83 9.60 19 421533 284 90206611
Cardiac arrest 31.65 9.60 674 420878 104261 90102634
Lung infiltration 31.63 9.60 148 421404 15134 90191761
Haemodynamic instability 31.50 9.60 123 421429 11616 90195279
Pregnancy 31.37 9.60 165 421387 61882 90145013
Cerebral aspergillosis 31.34 9.60 24 421528 551 90206344
Enterococcal infection 31.26 9.60 110 421442 9881 90197014
Adjustment disorder 31.18 9.60 4 421548 9638 90197257
Illness 31.14 9.60 238 421314 81731 90125164
Body height decreased 31.09 9.60 124 421428 11825 90195070
Klebsiella infection 31.04 9.60 112 421440 10185 90196710
Blood magnesium decreased 31.04 9.60 150 421402 15543 90191352
Corneal opacity 31.02 9.60 29 421523 882 90206013
Bacterial infection 30.97 9.60 201 421351 23243 90183652
Hypopyon 30.93 9.60 29 421523 885 90206010
Heavy menstrual bleeding 30.76 9.60 30 421522 20500 90186395
Peripheral swelling 30.73 9.60 1589 419963 411517 89795378
Gastroenteritis norovirus 30.65 9.60 46 421506 2330 90204565
Pupillary deformity 30.63 9.60 7 421545 0 90206895
Madarosis 30.47 9.60 58 421494 3571 90203324
Amnesia 30.43 9.60 340 421212 108165 90098730
Klebsiella bacteraemia 30.38 9.60 48 421504 2544 90204351
Feeling hot 30.36 9.60 521 421031 77487 90129408
Choroiditis 30.34 9.60 18 421534 266 90206629
Hydrocephalus 30.32 9.60 79 421473 6015 90200880
Enthesopathy 30.18 9.60 4 421548 9400 90197495
Radiculopathy 30.17 9.60 25 421527 18480 90188415
Eosinophilia 30.17 9.60 54 421498 28479 90178416
Diverticular perforation 30.10 9.60 59 421493 3713 90203182
Insurance issue 30.08 9.60 7 421545 10951 90195944
Herpes simplex oesophagitis 30.00 9.60 16 421536 190 90206705
Radiation skin injury 29.96 9.60 31 421521 1069 90205826
Tardive dyskinesia 29.96 9.60 7 421545 10923 90195972
Breast cancer female 29.80 9.60 16 421536 14870 90192025
Device breakage 29.76 9.60 14 421538 14030 90192865
Meningitis 29.72 9.60 97 421455 8384 90198511
Dyspepsia 29.72 9.60 698 420854 197462 90009433
Klebsiella sepsis 29.71 9.60 39 421513 1742 90205153
Hiatus hernia 29.60 9.60 45 421507 25316 90181579
Therapy interrupted 29.59 9.60 126 421426 49982 90156913
Neoplasm 29.58 9.60 100 421452 8803 90198092
Platelet transfusion 29.50 9.60 31 421521 1089 90205806
Lung disorder 29.37 9.60 505 421047 149378 90057517
Escherichia test positive 29.31 9.60 48 421504 2622 90204273
Liver function test increased 29.20 9.60 253 421299 84602 90122293
Pre-existing condition improved 29.18 9.60 4 421548 9165 90197730
Pseudomonas test positive 28.98 9.60 28 421524 888 90206007
Colitis microscopic 28.95 9.60 8 421544 11151 90195744
Oral pain 28.93 9.60 255 421297 32428 90174467
Pneumothorax 28.89 9.60 170 421382 18997 90187898
Product administration interrupted 28.80 9.60 11 421541 12481 90194414
Escherichia urinary tract infection 28.74 9.60 134 421418 13681 90193214
Poor venous access 28.72 9.60 29 421523 19498 90187397
Fusarium infection 28.59 9.60 30 421522 1052 90205843
Accidental overdose 28.57 9.60 55 421497 28218 90178677
Haemolytic anaemia 28.54 9.60 119 421433 11578 90195317
Neurological symptom 28.35 9.60 83 421469 6764 90200131
Parkinsonism 28.33 9.60 15 421537 14050 90192845
Obstructive airways disorder 28.22 9.60 48 421504 25821 90181074
Skin discolouration 28.22 9.60 323 421229 43992 90162903
Device leakage 28.19 9.60 6 421546 9985 90196910
Autonomic neuropathy 28.18 9.60 34 421518 1393 90205502
Blood pressure increased 28.12 9.60 700 420852 196517 90010378
Sensitivity to weather change 28.11 9.60 4 421548 8910 90197985
Pulmonary alveolar haemorrhage 28.06 9.60 76 421476 5922 90200973
Impaired quality of life 28.06 9.60 40 421512 23104 90183791
Myopathy 28.04 9.60 131 421421 13387 90193508
Perineal infection 27.99 9.60 15 421537 180 90206715
Glycosylated haemoglobin increased 27.98 9.60 19 421533 15543 90191352
Neurologic neglect syndrome 27.83 9.60 4 421548 8843 90198052
Malignant neoplasm of unknown primary site 27.80 9.60 18 421534 313 90206582
Encephalitis 27.74 9.60 114 421438 11020 90195875
Cytomegalovirus viraemia 27.71 9.60 88 421464 7498 90199397
Hypomagnesaemia 27.64 9.60 270 421282 35318 90171577
Myeloma cast nephropathy 27.58 9.60 14 421538 149 90206746
Affect lability 27.53 9.60 26 421526 18037 90188858
Chemotherapy 27.41 9.60 38 421514 1789 90205106
Labelled drug-drug interaction medication error 27.31 9.60 17 421535 14565 90192330
Disseminated cryptococcosis 27.19 9.60 25 421527 744 90206151
Eye irritation 27.15 9.60 75 421477 33903 90172992
Gene mutation 27.14 9.60 41 421511 2089 90204806
Infection reactivation 27.11 9.60 39 421513 1901 90204994
Pneumococcal sepsis 27.07 9.60 27 421525 891 90206004
Drug interaction 26.98 9.60 1032 420520 275421 89931474
Enterocolitis infectious 26.94 9.60 40 421512 2007 90204888
Hypertransaminasaemia 26.92 9.60 145 421407 15680 90191215
Compression fracture 26.84 9.60 96 421456 8693 90198202
Blood fibrinogen decreased 26.65 9.60 30 421522 1140 90205755
Leukaemic infiltration extramedullary 26.64 9.60 14 421538 161 90206734
Hypophagia 26.63 9.60 270 421282 35667 90171228
Oral candidiasis 26.57 9.60 267 421285 35188 90171707
Body dysmorphic disorder 26.54 9.60 19 421533 392 90206503
Exposure to toxic agent 26.52 9.60 3 421549 7964 90198931
Pseudomonas infection 26.52 9.60 138 421414 14727 90192168
Anxiety 26.49 9.60 1174 420378 308598 89898297
Device related infection 26.46 9.60 208 421344 25578 90181317
Pulmonary arterial hypertension 26.41 9.60 51 421501 26136 90180759
Crossmatch incompatible 26.32 9.60 9 421543 30 90206865
Ovarian cyst 26.31 9.60 25 421527 17293 90189602
Systemic mycosis 26.29 9.60 34 421518 1496 90205399
Adenocarcinoma of colon 26.27 9.60 47 421505 2759 90204136
Alveolitis 26.26 9.60 49 421503 2972 90203923
Foot operation 26.24 9.60 5 421547 8996 90197899
Erysipelas 26.06 9.60 97 421455 8955 90197940
Leukocytosis 26.00 9.60 239 421313 30751 90176144
Deformity 26.00 9.60 12 421540 12158 90194737
Hepatic failure 25.95 9.60 291 421261 39437 90167458
Paradoxical drug reaction 25.92 9.60 72 421480 5694 90201201
Spondylitis 25.91 9.60 17 421535 14161 90192734
Leukaemia recurrent 25.84 9.60 33 421519 1434 90205461
Toxic neuropathy 25.84 9.60 21 421531 527 90206368
Streptococcal bacteraemia 25.77 9.60 41 421511 2186 90204709
Bronchiectasis 25.70 9.60 40 421512 22290 90184605
Device malfunction 25.68 9.60 36 421516 20941 90185954
Phyllodes tumour 25.61 9.60 11 421541 77 90206818
Hysterectomy 25.41 9.60 11 421541 11573 90195322
Gastrointestinal fungal infection 25.31 9.60 19 421533 423 90206472
Guillain-Barre syndrome 25.26 9.60 62 421490 4550 90202345
Blood lactate dehydrogenase decreased 25.20 9.60 15 421537 223 90206672
Maternal exposure timing unspecified 25.19 9.60 41 421511 22442 90184453
Subcutaneous drug absorption impaired 25.08 9.60 16 421536 13529 90193366
Fungaemia 25.05 9.60 51 421501 3299 90203596
Chalazion 25.05 9.60 21 421531 551 90206344
Antithrombin III decreased 24.91 9.60 15 421537 228 90206667
Drug tolerance decreased 24.88 9.60 72 421480 32058 90174837
Lymphocyte count decreased 24.86 9.60 261 421291 34789 90172106
Uterine perforation 24.76 9.60 3 421549 7551 90199344
T-cell lymphoma refractory 24.71 9.60 10 421542 59 90206836
Meningitis bacterial 24.70 9.60 35 421517 1682 90205213
Cholelithiasis 24.70 9.60 143 421409 52363 90154532
Mesenteric abscess 24.58 9.60 11 421541 86 90206809
Nephrolithiasis 24.55 9.60 131 421421 48954 90157941
Hyperglycaemic hyperosmolar nonketotic syndrome 24.43 9.60 31 421521 1338 90205557
Rhabdomyolysis 24.43 9.60 139 421413 51117 90155778
Dysaesthesia pharynx 24.38 9.60 14 421538 194 90206701
Poisoning 24.27 9.60 21 421531 15196 90191699
Non-small cell lung cancer 24.10 9.60 59 421493 4322 90202573
Transplant 24.07 9.60 27 421525 1022 90205873
Lymphoedema 24.07 9.60 127 421425 13626 90193269
Infusion site reaction 23.99 9.60 32 421520 19007 90187888
SARS-CoV-2 test positive 23.94 9.60 109 421443 11019 90195876
Hyperamylasaemia 23.81 9.60 20 421532 526 90206369
Ear canal erythema 23.79 9.60 9 421543 43 90206852
Hereditary angioedema 23.77 9.60 7 421545 9358 90197537
Blood calcium abnormal 23.71 9.60 37 421515 1940 90204955
Large intestinal ulcer perforation 23.53 9.60 10 421542 68 90206827
Spinal fusion surgery 23.45 9.60 14 421538 12269 90194626
Minimal residual disease 23.40 9.60 18 421534 416 90206479
Acinetobacter infection 23.28 9.60 37 421515 1971 90204924
Palmar erythema 23.24 9.60 36 421516 1875 90205020
Alopecia areata 23.18 9.60 37 421515 1978 90204917
Atrial septal defect 23.12 9.60 5 421547 8229 90198666
Spinal compression fracture 23.12 9.60 135 421417 15043 90191852
Iridocyclitis 23.08 9.60 52 421500 3609 90203286
Sneezing 23.08 9.60 67 421485 29802 90177093
Tendonitis 23.00 9.60 40 421512 21332 90185563
Cancer pain 22.99 9.60 55 421497 3970 90202925
Breast cancer stage I 22.99 9.60 8 421544 9616 90197279
Live birth 22.93 9.60 246 421306 78861 90128034
Blood disorder 22.87 9.60 84 421468 7706 90199189
Incorrect product administration duration 22.83 9.60 34 421518 19288 90187607
CSF oligoclonal band present 22.79 9.60 18 421534 433 90206462
Soft tissue disorder 22.78 9.60 57 421495 4233 90202662
Syncope 22.77 9.60 792 420760 131871 90075024
Nasal abscess 22.77 9.60 13 421539 178 90206717
Venous thrombosis limb 22.76 9.60 50 421502 3412 90203483
Tonsillar disorder 22.70 9.60 28 421524 1174 90205721
Allergy test negative 22.69 9.60 14 421538 223 90206672
Breast cancer stage II 22.66 9.60 86 421466 35248 90171647
Alveolar proteinosis 22.63 9.60 24 421528 852 90206043
Engraftment syndrome 22.63 9.60 22 421530 703 90206192
Therapeutic response unexpected 22.60 9.60 42 421510 21838 90185057
Resuscitation 22.58 9.60 29 421523 1267 90205628
Lactose intolerance 22.53 9.60 49 421503 3320 90203575
Cardiac murmur 22.50 9.60 31 421521 18163 90188732
Miosis 22.46 9.60 8 421544 9476 90197419
Depressed mood 22.45 9.60 139 421413 50083 90156812
Multiple drug therapy 22.45 9.60 3 421549 7006 90199889
Ulcer 22.43 9.60 78 421474 32804 90174091
Listeria sepsis 22.35 9.60 22 421530 714 90206181
Cerebral toxoplasmosis 22.26 9.60 30 421522 1375 90205520
Tumour pain 22.19 9.60 35 421517 1852 90205043
Eosinophil count increased 22.17 9.60 17 421535 13064 90193831
Birdshot chorioretinopathy 22.15 9.60 10 421542 80 90206815
Intraocular pressure decreased 22.09 9.60 11 421541 112 90206783
Dysaesthesia 22.05 9.60 64 421488 5191 90201704
Extrapyramidal disorder 22.00 9.60 26 421526 16277 90190618
Nodule 22.00 9.60 58 421494 26628 90180267
Infection in an immunocompromised host 21.97 9.60 24 421528 882 90206013
Metapneumovirus infection 21.91 9.60 29 421523 1306 90205589
Gastric perforation 21.87 9.60 36 421516 1975 90204920
Intracranial tumour haemorrhage 21.84 9.60 14 421538 239 90206656
Acute monocytic leukaemia 21.83 9.60 12 421540 152 90206743
Anti-cyclic citrullinated peptide antibody 21.81 9.60 60 421492 27161 90179734
Cerebral venous thrombosis 21.80 9.60 39 421513 2289 90204606
Stress cardiomyopathy 21.80 9.60 121 421431 13234 90193661
X-ray abnormal 21.75 9.60 123 421429 45301 90161594
Necrotising retinitis 21.69 9.60 19 421533 530 90206365
Gastrointestinal necrosis 21.68 9.60 47 421505 3178 90203717
Blood gases abnormal 21.64 9.60 24 421528 897 90205998
Cranial nerve palsies multiple 21.64 9.60 10 421542 85 90206810
Balamuthia infection 21.64 9.60 10 421542 85 90206810
Meningitis pneumococcal 21.57 9.60 18 421534 469 90206426
Sinus congestion 21.57 9.60 61 421491 27363 90179532
Right ventricular failure 21.54 9.60 35 421517 19170 90187725
Respiratory tract congestion 21.53 9.60 61 421491 27349 90179546
Gastrointestinal protozoal infection 21.53 9.60 7 421545 19 90206876
Gangrene 21.49 9.60 17 421535 12859 90194036
Philadelphia chromosome positive 21.48 9.60 18 421534 472 90206423
Platelet disorder 21.43 9.60 39 421513 2320 90204575
Iron deficiency anaemia 21.42 9.60 49 421503 23613 90183282
Intracranial mass 21.39 9.60 28 421524 1247 90205648
Neoplasm skin 21.36 9.60 46 421506 3096 90203799
Blindness 21.34 9.60 203 421349 26365 90180530
Tuberculoma of central nervous system 21.32 9.60 16 421536 356 90206539
Intentional dose omission 21.30 9.60 31 421521 17752 90189143
Oral disorder 21.27 9.60 100 421452 10245 90196650
Hypophosphataemia 21.27 9.60 130 421422 14724 90192171
Candida pneumonia 21.23 9.60 13 421539 204 90206691
Plasma cell myeloma in remission 21.21 9.60 6 421546 8 90206887
Rash maculo-papular 21.18 9.60 287 421265 40646 90166249
Superficial spreading melanoma stage unspecified 21.17 9.60 12 421540 162 90206733
Device adhesion issue 21.11 9.60 3 421549 6688 90200207
Varicella zoster virus infection 21.10 9.60 52 421500 3825 90203070
Cushingoid 21.02 9.60 100 421452 10295 90196600
Acute hepatic failure 21 9.60 178 421374 22383 90184512
Cellulitis 20.95 9.60 565 420987 90772 90116123
Endocarditis bacterial 20.94 9.60 20 421532 625 90206270
B-cell aplasia 20.92 9.60 14 421538 258 90206637
White blood cell disorder 20.85 9.60 44 421508 2920 90203975
Bacillus infection 20.85 9.60 24 421528 935 90205960
Polyp 20.75 9.60 5 421547 7639 90199256
Immunodeficiency 20.74 9.60 117 421435 43117 90163778
Acute pulmonary oedema 20.73 9.60 94 421458 9486 90197409
Multiple allergies 20.71 9.60 131 421421 15015 90191880
Skin toxicity 20.66 9.60 74 421478 6705 90200190
Hypotony of eye 20.64 9.60 13 421539 215 90206680
Cerebral artery thrombosis 20.57 9.60 17 421535 437 90206458
Epstein-Barr virus infection 20.55 9.60 99 421453 10245 90196650
Subclavian vein thrombosis 20.53 9.60 36 421516 2080 90204815
Oesophageal squamous cell carcinoma 20.53 9.60 11 421541 132 90206763
Vitritis 20.47 9.60 31 421521 1583 90205312
Visual acuity reduced 20.38 9.60 182 421370 23228 90183667
Lineage switch leukaemia 20.38 9.60 8 421544 43 90206852
Product packaging confusion 20.38 9.60 13 421539 220 90206675
Meningitis candida 20.37 9.60 9 421543 68 90206827
Retinal ischaemia 20.37 9.60 17 421535 443 90206452
Movement disorder 20.36 9.60 68 421484 28951 90177944
Spinal operation 20.35 9.60 11 421541 10185 90196710
Blood pressure diastolic increased 20.35 9.60 18 421534 12888 90194007
Monoparesis 20.34 9.60 35 421517 1992 90204903
Babesiosis 20.33 9.60 14 421538 271 90206624
Diverticulitis 20.27 9.60 309 421243 44878 90162017
Nail infection 20.25 9.60 40 421512 2532 90204363
Hypertensive crisis 20.25 9.60 147 421405 17637 90189258
Pneumocystis jirovecii infection 20.18 9.60 34 421518 1902 90204993
Neurological decompensation 20.17 9.60 48 421504 3453 90203442
Amenorrhoea 20.17 9.60 15 421537 11707 90195188
Swollen tongue 20.13 9.60 313 421239 45643 90161252
Immunosuppression 20.10 9.60 110 421442 11967 90194928
Catabolic state 20.08 9.60 8 421544 45 90206850
Bing-Neel syndrome 20.05 9.60 6 421546 11 90206884
Libido increased 20.03 9.60 32 421520 1712 90205183
Adenocarcinoma pancreas 20.00 9.60 26 421526 1150 90205745
Meningoencephalitis herpetic 19.91 9.60 29 421523 1430 90205465
Lip swelling 19.90 9.60 102 421450 38508 90168387
Precursor B-lymphoblastic lymphoma 19.89 9.60 7 421545 26 90206869
Fluid intake reduced 19.82 9.60 53 421499 4099 90202796
Tachypnoea 19.77 9.60 168 421384 21141 90185754
Recall phenomenon 19.74 9.60 22 421530 827 90206068
Eastern Cooperative Oncology Group performance status improved 19.72 9.60 6 421546 12 90206883
Appendicitis 19.67 9.60 97 421455 10134 90196761
Seasonal allergy 19.66 9.60 178 421374 22805 90184090
Product prescribing error 19.57 9.60 73 421479 30072 90176823
Akathisia 19.56 9.60 14 421538 11145 90195750
Refractory anaemia with ringed sideroblasts 19.54 9.60 5 421547 3 90206892
Soft tissue injury 19.53 9.60 35 421517 2057 90204838
Foetal growth restriction 19.53 9.60 91 421461 9289 90197606
Renal impairment 19.52 9.60 635 420917 104786 90102109
Postictal state 19.46 9.60 28 421524 1365 90205530
Aspiration bone marrow 19.45 9.60 12 421540 191 90206704
Streptococcal sepsis 19.43 9.60 48 421504 3536 90203359
Iris adhesions 19.37 9.60 16 421536 411 90206484
Clostridium bacteraemia 19.36 9.60 13 421539 241 90206654
Hyphaema 19.34 9.60 15 421537 351 90206544
Drug clearance decreased 19.34 9.60 33 421519 1865 90205030
Anaphylactoid reaction 19.31 9.60 55 421497 4413 90202482
Hepatitis 19.30 9.60 223 421329 70516 90136379
Hyperproteinaemia 19.24 9.60 11 421541 151 90206744
Pulse absent 19.23 9.60 67 421485 5988 90200907
Mania 19.22 9.60 122 421430 14002 90192893
Graft versus host disease 19.21 9.60 82 421470 8062 90198833
Nail dystrophy 19.16 9.60 27 421525 1291 90205604
Peritonitis 19.16 9.60 157 421395 19548 90187347
Ischaemic stroke 19.13 9.60 172 421380 21994 90184901
Pulse waveform abnormal 19.13 9.60 9 421543 80 90206815
Vascular pain 19.13 9.60 23 421529 939 90205956
Cardiomyopathy 19.12 9.60 160 421392 20046 90186849
Tumour pseudoprogression 19.07 9.60 20 421532 701 90206194
Device use error 19.07 9.60 5 421547 7216 90199679
Blood stem cell harvest failure 19.03 9.60 9 421543 81 90206814
Ankle brachial index decreased 19.03 9.60 9 421543 81 90206814
Necrotising fasciitis 19.00 9.60 50 421502 3830 90203065
Therapeutic response decreased 19.00 9.60 298 421254 89431 90117464
Cataract traumatic 18.96 9.60 5 421547 4 90206891
Differentiation syndrome 18.96 9.60 27 421525 1304 90205591
Bone infarction 18.95 9.60 16 421536 424 90206471
Superior sagittal sinus thrombosis 18.93 9.60 21 421531 785 90206110
Fear 18.92 9.60 30 421522 16592 90190303
Refractory anaemia with an excess of blasts 18.85 9.60 16 421536 427 90206468
Protein urine 18.81 9.60 21 421531 791 90206104
Retinal detachment 18.73 9.60 72 421480 6750 90200145
Arachnoiditis 18.70 9.60 18 421534 568 90206327
Vaginal discharge 18.69 9.60 39 421513 19425 90187470
Enlarged uvula 18.67 9.60 12 421540 206 90206689
Aortitis 18.66 9.60 27 421525 1323 90205572
Atypical haemolytic uraemic syndrome 18.58 9.60 23 421529 968 90205927
Nasal oedema 18.48 9.60 4 421548 6580 90200315
Diabetes insipidus 18.47 9.60 44 421508 3168 90203727
Maternal exposure before pregnancy 18.47 9.60 15 421537 11198 90195697
Miliary pneumonia 18.41 9.60 7 421545 34 90206861
Cerebellar haemangioma 18.39 9.60 9 421543 88 90206807
Scar 18.28 9.60 27 421525 15368 90191527
Dermatitis acneiform 18.22 9.60 68 421484 6286 90200609
Sense of oppression 18.21 9.60 24 421528 1076 90205819
Drug level increased 18.18 9.60 67 421485 27695 90179200
Porphyria acute 18.13 9.60 35 421517 17940 90188955
Bone debridement 18.03 9.60 12 421540 219 90206676
Procalcitonin abnormal 18.02 9.60 6 421546 18 90206877
Subcutaneous emphysema 18.01 9.60 24 421528 1088 90205807
Cytomegalovirus colitis 17.99 9.60 45 421507 3341 90203554
Hepatitis B 17.97 9.60 54 421498 4465 90202430
Bronchitis pneumococcal 17.96 9.60 5 421547 6 90206889
Genital haemorrhage 17.95 9.60 9 421543 8693 90198202
Bacterial colitis 17.95 9.60 11 421541 173 90206722
Eosinophilic cystitis 17.94 9.60 8 421544 62 90206833
Lividity 17.88 9.60 15 421537 394 90206501
Cyanosis 17.85 9.60 153 421399 19302 90187593
Aspergilloma 17.84 9.60 13 421539 276 90206619
Pseudomyopia 17.83 9.60 8 421544 63 90206832
Product administration error 17.81 9.60 63 421489 26360 90180535
Failure to thrive 17.81 9.60 82 421470 8329 90198566
Disturbance in attention 17.79 9.60 137 421415 46972 90159923
Device failure 17.79 9.60 5 421547 6892 90200003
Cystitis bacterial 17.72 9.60 14 421538 337 90206558
Hair texture abnormal 17.70 9.60 55 421497 4632 90202263
Myalgia 17.68 9.60 651 420901 174474 90032421
Chronic myelomonocytic leukaemia 17.65 9.60 15 421537 401 90206494
Carotid intima-media thickness increased 17.63 9.60 9 421543 97 90206798
Thrombophlebitis 17.63 9.60 56 421496 4772 90202123
Metastatic malignant melanoma 17.57 9.60 29 421523 1595 90205300
Anticipatory anxiety 17.54 9.60 25 421527 1208 90205687
Wrong technique in device usage process 17.53 9.60 3 421549 5832 90201063
Vitreous loss 17.50 9.60 4 421548 0 90206895
Colony stimulating factor therapy 17.41 9.60 15 421537 409 90206486
Plasma cells increased 17.40 9.60 9 421543 100 90206795
Abnormal dreams 17.39 9.60 16 421536 11241 90195654
Vascular device infection 17.37 9.60 105 421447 11847 90195048
Product substitution issue 17.37 9.60 36 421516 17972 90188923
Respiratory tract infection viral 17.36 9.60 42 421510 3054 90203841
Pharyngeal inflammation 17.35 9.60 23 421529 1037 90205858
Heart rate decreased 17.33 9.60 162 421390 53343 90153552
Rectal adenocarcinoma 17.31 9.60 19 421533 702 90206193
Myositis 17.30 9.60 56 421496 24072 90182823
Hyperkalaemia 17.26 9.60 206 421346 64758 90142137
Herpes zoster 17.25 9.60 569 420983 94075 90112820
Adenovirus infection 17.23 9.60 54 421498 4568 90202327
Dry skin 17.22 9.60 534 421018 87539 90119356
Hallucination 17.20 9.60 210 421342 65749 90141146
Visceral leishmaniasis 17.16 9.60 18 421534 631 90206264
Atypical pneumonia 17.15 9.60 58 421494 5106 90201789
Mucocutaneous ulceration 17.13 9.60 12 421540 239 90206656
Mood swings 17.06 9.60 45 421507 20657 90186238
Depressed level of consciousness 17.05 9.60 237 421315 72547 90134348
Septic pulmonary embolism 17.02 9.60 10 421542 145 90206750
Urinary tract infection enterococcal 17.00 9.60 41 421511 2975 90203920
Diarrhoea haemorrhagic 17.00 9.60 96 421456 10567 90196328
Tooth erosion 16.99 9.60 16 421536 491 90206404
Rotator cuff syndrome 16.94 9.60 30 421522 15889 90191006
Creatinine renal clearance 16.91 9.60 6 421546 23 90206872
Product dose omission issue 16.84 9.60 1149 420403 290538 89916357
Drug resistance 16.80 9.60 216 421336 30233 90176662
Hyperferritinaemia 16.77 9.60 14 421538 365 90206530
Light chain analysis decreased 16.77 9.60 5 421547 9 90206886
Paraplegia 16.74 9.60 44 421508 3368 90203527
Foetal exposure during pregnancy 16.71 9.60 287 421265 42688 90164207
N-terminal prohormone brain natriuretic peptide decreased 16.71 9.60 6 421546 24 90206871
Haemolytic uraemic syndrome 16.70 9.60 39 421513 2772 90204123
Paraparesis 16.63 9.60 40 421512 2898 90203997
Eye abscess 16.61 9.60 10 421542 152 90206743
Product preparation error 16.56 9.60 14 421538 10247 90196648
Thiopurine methyltransferase decreased 16.56 9.60 13 421539 310 90206585
Muscular weakness 16.49 9.60 789 420763 205877 90001018
Motor dysfunction 16.47 9.60 41 421511 19189 90187706
Malignant transformation 16.46 9.60 17 421535 585 90206310
Gastroenteritis astroviral 16.45 9.60 8 421544 77 90206818
Muscle spasms 16.44 9.60 1373 420179 250510 89956385
Chemical burns of eye 16.37 9.60 8 421544 78 90206817
Feeling jittery 16.33 9.60 125 421427 15246 90191649
Blood calcium increased 16.31 9.60 104 421448 11954 90194941
Listeria encephalitis 16.30 9.60 12 421540 259 90206636
Immune system disorder 16.30 9.60 103 421449 11802 90195093
Meniscus injury 16.28 9.60 9 421543 8228 90198667
Histiocytic sarcoma 16.28 9.60 8 421544 79 90206816
Face oedema 16.24 9.60 173 421379 23145 90183750
Disorientation 16.22 9.60 292 421260 43822 90163073
Cholangitis infective 16.21 9.60 15 421537 450 90206445
Corneal perforation 16.20 9.60 17 421535 596 90206299
Humerus fracture 16.20 9.60 89 421463 9696 90197199
Suffocation feeling 16.19 9.60 28 421524 1600 90205295
Pericardial effusion 16.19 9.60 251 421301 36582 90170313
Virilism 16.18 9.60 7 421545 50 90206845
Post-traumatic neck syndrome 16.18 9.60 36 421516 2478 90204417
Product dispensing error 16.11 9.60 20 421532 12253 90194642
Sialoadenitis 16.06 9.60 33 421519 2149 90204746
Salmonella bacteraemia 16.06 9.60 10 421542 162 90206733
Target skin lesion 16.04 9.60 9 421543 119 90206776
Capillary leak syndrome 16.01 9.60 38 421514 2729 90204166
Hepatosplenomegaly 16.00 9.60 40 421512 2969 90203926
Blood parathyroid hormone decreased 15.94 9.60 20 421532 12196 90194699
Injection site discolouration 15.94 9.60 12 421540 9308 90197587
Blood stem cell transplant failure 15.92 9.60 11 421541 214 90206681
Product blister packaging issue 15.90 9.60 13 421539 329 90206566
Nightmare 15.88 9.60 50 421502 21675 90185220
Hypogeusia 15.87 9.60 27 421525 1522 90205373
Fungal abscess central nervous system 15.81 9.60 5 421547 12 90206883
Respiratory depth decreased 15.81 9.60 6 421546 29 90206866
Gastroenteritis viral 15.75 9.60 80 421472 30275 90176620
Panic attack 15.75 9.60 66 421486 26299 90180596
Treatment noncompliance 15.75 9.60 159 421393 51568 90155327
Low density lipoprotein increased 15.74 9.60 9 421543 8076 90198819
Vision blurred 15.70 9.60 645 420907 109648 90097247
Angina pectoris 15.69 9.60 112 421440 39048 90167847
Pseudomonal bacteraemia 15.68 9.60 31 421521 1963 90204932
Blood creatinine increased 15.62 9.60 598 420954 100788 90106107
Lymphorrhoea 15.61 9.60 7 421545 55 90206840
Pulmonary trichosporonosis 15.61 9.60 7 421545 55 90206840
Panniculitis 15.61 9.60 27 421525 14431 90192464
Brain neoplasm 15.60 9.60 54 421498 4810 90202085
Oncologic complication 15.58 9.60 11 421541 222 90206673
Somnolence 15.56 9.60 804 420748 208280 89998615
Quadriplegia 15.56 9.60 33 421519 2198 90204697
Macular hole 15.55 9.60 21 421531 964 90205931
Electrophoresis protein abnormal 15.53 9.60 5 421547 13 90206882
Excessive eye blinking 15.52 9.60 25 421527 1347 90205548
Generalised oedema 15.51 9.60 146 421406 18907 90187988
Staphylococcus test positive 15.50 9.60 50 421502 4295 90202600
Infusion site swelling 15.49 9.60 19 421533 11701 90195194
Lymphangitis 15.49 9.60 21 421531 968 90205927
Dysentery 15.48 9.60 22 421530 1060 90205835
Intervertebral disc degeneration 15.45 9.60 36 421516 17238 90189657
Non-small cell lung cancer metastatic 15.36 9.60 19 421533 799 90206096
Clostridial sepsis 15.34 9.60 16 421536 557 90206338
Genital rash 15.32 9.60 17 421535 636 90206259
Haemorrhoidal haemorrhage 15.29 9.60 57 421495 5266 90201629
Oophoritis 15.29 9.60 10 421542 177 90206718
Haemophilus bacteraemia 15.28 9.60 4 421548 3 90206892
Salmonellosis 15.20 9.60 24 421528 1271 90205624
Pleocytosis 15.18 9.60 21 421531 987 90205908
Neuralgia 15.15 9.60 218 421334 31282 90175613
Klebsiella test positive 15.14 9.60 26 421526 1477 90205418
Hostility 15.14 9.60 33 421519 2240 90204655
Cerebral haemorrhage 15.08 9.60 235 421317 34287 90172608
Spinal cord injury 15.07 9.60 22 421530 1087 90205808
Anhidrosis 15.05 9.60 10 421542 182 90206713
Hypergeusia 15.01 9.60 5 421547 15 90206880
Light chain analysis 15.01 9.60 5 421547 15 90206880
Meningitis streptococcal 14.99 9.60 9 421543 136 90206759
Application site erythema 14.96 9.60 3 421549 5205 90201690
Subileus 14.92 9.60 44 421508 3600 90203295
Unintentional medical device removal 14.91 9.60 7 421545 7023 90199872
Jugular vein occlusion 14.90 9.60 7 421545 62 90206833
American trypanosomiasis 14.84 9.60 11 421541 240 90206655
Skin candida 14.84 9.60 28 421524 1713 90205182
Drug level decreased 14.83 9.60 14 421538 9716 90197179
Glioblastoma multiforme 14.82 9.60 20 421532 918 90205977
Renal disorder 14.78 9.60 253 421299 37606 90169289
Prohormone brain natriuretic peptide increased 14.77 9.60 12 421540 301 90206594
Paraesthesia 14.71 9.60 1354 420198 248972 89957923
Pneumonia cryptococcal 14.71 9.60 23 421529 1208 90205687
Product adhesion issue 14.69 9.60 3 421549 5139 90201756
Bone marrow transplant 14.60 9.60 19 421533 841 90206054
Lung abscess 14.59 9.60 32 421520 2181 90204714
Vein discolouration 14.57 9.60 12 421540 307 90206588
Ataxia 14.56 9.60 138 421414 17904 90188991
Hallucination, auditory 14.52 9.60 33 421519 15942 90190953
Mastocytosis 14.52 9.60 20 421532 936 90205959
Blood albumin abnormal 14.47 9.60 22 421530 1127 90205768
Protein total abnormal 14.47 9.60 16 421536 596 90206299
Foot fracture 14.45 9.60 69 421483 26537 90180358
Pneumonia respiratory syncytial viral 14.45 9.60 24 421528 1327 90205568
Acute polyneuropathy 14.41 9.60 14 421538 447 90206448
Sickle cell anaemia with crisis 14.38 9.60 8 421544 7289 90199606
Aortic arteriosclerosis 14.33 9.60 9 421543 7675 90199220
Bordetella infection 14.33 9.60 5 421547 18 90206877
Left ventricular dysfunction 14.33 9.60 117 421435 14552 90192343
Secretion discharge 14.32 9.60 33 421519 15863 90191032
Muscle rigidity 14.32 9.60 28 421524 14281 90192614
Natural killer cell count decreased 14.31 9.60 8 421544 105 90206790
Acne 14.30 9.60 76 421476 28431 90178464
Acute sinusitis 14.28 9.60 48 421504 4213 90202682
Botryomycosis 14.22 9.60 6 421546 40 90206855
Tumour associated fever 14.21 9.60 14 421538 455 90206440
Aspartate aminotransferase increased 14.20 9.60 600 420952 102337 90104558
Serum ferritin increased 14.20 9.60 70 421482 7311 90199584
Beta 2 microglobulin increased 14.20 9.60 11 421541 257 90206638
Bacterial endophthalmitis 14.20 9.60 10 421542 201 90206694
Unmasking of previously unidentified disease 14.18 9.60 25 421527 1451 90205444
Vanishing bile duct syndrome 14.17 9.60 24 421528 1348 90205547
Nail bed inflammation 14.17 9.60 28 421524 1773 90205122
Facial paralysis 14.16 9.60 122 421430 15412 90191483
Cerebral venous sinus thrombosis 14.15 9.60 33 421519 2343 90204552
Hernia 14.11 9.60 28 421524 14203 90192692
Overweight 14.06 9.60 5 421547 5929 90200966
Hemiparesis 14.05 9.60 217 421335 31602 90175293
Oesophageal candidiasis 14.03 9.60 66 421486 6763 90200132
Petechiae 14.03 9.60 123 421429 15618 90191277
Cerebral infarction 13.98 9.60 187 421365 26409 90180486
Gastrointestinal inflammation 13.97 9.60 65 421487 6631 90200264
Carotid artery thrombosis 13.96 9.60 13 421539 9079 90197816
Catheterisation cardiac 13.94 9.60 3 421549 4953 90201942
Panophthalmitis 13.83 9.60 9 421543 158 90206737
Microangiopathic haemolytic anaemia 13.76 9.60 18 421534 801 90206094
Superior vena cava occlusion 13.75 9.60 7 421545 75 90206820
Cholangiocarcinoma 13.74 9.60 23 421529 1280 90205615
Quadriparesis 13.68 9.60 34 421518 2515 90204380
Central nervous system vasculitis 13.64 9.60 21 421531 1088 90205807
Anhedonia 13.62 9.60 20 421532 11411 90195484
Transaminases increased 13.61 9.60 246 421306 36946 90169949
Meningitis tuberculous 13.52 9.60 16 421536 642 90206253
Somnambulism 13.52 9.60 6 421546 6222 90200673
Spinal stenosis 13.52 9.60 39 421513 17385 90189510
Sinus polyp 13.51 9.60 13 421539 410 90206485
Lipogranuloma 13.49 9.60 4 421548 7 90206888
Substance-induced mood disorder 13.49 9.60 4 421548 7 90206888
Choroidal detachment 13.47 9.60 11 421541 278 90206617
Colitis ischaemic 13.46 9.60 101 421451 12245 90194650
Infusion related hypersensitivity reaction 13.45 9.60 16 421536 646 90206249
Dizziness 13.43 9.60 2475 419077 586809 89620086
Xeroderma 13.42 9.60 12 421540 344 90206551
Herpes zoster meningoencephalitis 13.41 9.60 13 421539 414 90206481
Sarcoidosis 13.39 9.60 18 421534 10655 90196240
Rales 13.35 9.60 34 421518 15793 90191102
Hypomania 13.33 9.60 13 421539 8884 90198011
Sexual dysfunction 13.32 9.60 3 421549 4801 90202094
Needle issue 13.31 9.60 28 421524 13906 90192989
Peritonitis viral 13.29 9.60 6 421546 48 90206847
Bronchitis viral 13.29 9.60 22 421530 1213 90205682
Embolism venous 13.23 9.60 42 421510 3578 90203317
Oral dysaesthesia 13.21 9.60 8 421544 123 90206772
Uterine fistula 13.20 9.60 5 421547 24 90206871
Toxic leukoencephalopathy 13.19 9.60 18 421534 835 90206060
Adenoviral haemorrhagic cystitis 13.17 9.60 9 421543 172 90206723
Free fatty acids increased 13.14 9.60 4 421548 8 90206887
Leukaemic lymphoma 13.14 9.60 7 421545 83 90206812
Anaphylactoid shock 13.13 9.60 13 421539 425 90206470
Alopecia totalis 13.13 9.60 13 421539 425 90206470
Cleft palate repair 13.13 9.60 3 421549 0 90206895
Cavernous sinus syndrome 13.13 9.60 3 421549 0 90206895
Influenza A virus test 13.13 9.60 3 421549 0 90206895
Debridement 13.10 9.60 22 421530 1227 90205668
Oedema peripheral 13.10 9.60 1381 420171 256534 89950361
Decubitus ulcer 13.08 9.60 97 421455 11716 90195179
Energy increased 13.02 9.60 38 421514 3092 90203803
Chorioretinal scar 12.98 9.60 6 421546 51 90206844
Vitrectomy 12.97 9.60 10 421542 232 90206663
Pneumopericardium 12.92 9.60 7 421545 86 90206809
Iris transillumination defect 12.88 9.60 8 421544 129 90206766
Diastolic hypotension 12.85 9.60 7 421545 87 90206808
Ileal perforation 12.82 9.60 14 421538 514 90206381
Polychromasia 12.82 9.60 10 421542 236 90206659
Mucosal infection 12.81 9.60 9 421543 180 90206715
Injection site irritation 12.74 9.60 6 421546 6009 90200886
Central nervous system infection 12.74 9.60 18 421534 863 90206032
Transplant rejection 12.73 9.60 25 421527 12733 90194162
Respiratory depression 12.73 9.60 34 421518 15541 90191354
Trichosporon infection 12.73 9.60 12 421540 369 90206526
Hyperchylomicronaemia 12.69 9.60 6 421546 54 90206841
Laryngeal inflammation 12.67 9.60 8 421544 133 90206762
Osteomyelitis bacterial 12.65 9.60 10 421542 241 90206654
Gastrointestinal motility disorder 12.61 9.60 59 421493 6032 90200863
CSF test abnormal 12.57 9.60 14 421538 526 90206369
Colorectal adenocarcinoma 12.52 9.60 9 421543 187 90206708
Major depression 12.51 9.60 17 421535 10018 90196877
Hemianopia 12.49 9.60 29 421523 2053 90204842
Bipolar disorder 12.48 9.60 14 421538 8971 90197924
Cancer fatigue 12.48 9.60 9 421543 188 90206707
Skin haemorrhage 12.48 9.60 54 421498 21326 90185569
Pseudocellulitis 12.46 9.60 8 421544 137 90206758
Vaccination site pain 12.46 9.60 12 421540 379 90206516
Grip strength 12.42 9.60 14 421538 8951 90197944
Granuloma skin 12.42 9.60 19 421533 10661 90196234
Urinary tract infection bacterial 12.38 9.60 60 421492 6225 90200670
Scleroderma-like reaction 12.36 9.60 8 421544 139 90206756
Dissociation 12.34 9.60 8 421544 6707 90200188
Cytomegalovirus myocarditis 12.32 9.60 6 421546 58 90206837
Aortic thrombosis 12.31 9.60 22 421530 1290 90205605
Autoimmune thyroiditis 12.30 9.60 6 421546 5887 90201008
Hair colour changes 12.28 9.60 40 421512 3454 90203441
VIIIth nerve injury 12.27 9.60 4 421548 11 90206884
Haemorrhage intracranial 12.25 9.60 116 421436 15046 90191849
Hypertrophic cardiomyopathy 12.25 9.60 30 421522 2198 90204697
Coronary artery occlusion 12.25 9.60 13 421539 8541 90198354
Sensory loss 12.25 9.60 43 421509 18032 90188863
Body temperature decreased 12.22 9.60 63 421489 23753 90183142
Limb operation 12.21 9.60 3 421549 4524 90202371
Nail discolouration 12.20 9.60 38 421514 3204 90203691
Ovarian cancer 12.19 9.60 63 421489 6704 90200191
Cyst 12.18 9.60 38 421514 16523 90190372
Cataract subcapsular 12.18 9.60 16 421536 715 90206180
Viral myelitis 12.15 9.60 5 421547 31 90206864
Stomatitis 12.13 9.60 1106 420446 273592 89933303
Central nervous system injury 12.07 9.60 8 421544 145 90206750
Ultrasound foetal abnormal 12.07 9.60 8 421544 145 90206750
Paronychia 12.06 9.60 71 421481 7935 90198960
Hepatic infection fungal 12.06 9.60 6 421546 61 90206834
Streptococcus test positive 12.02 9.60 23 421529 1422 90205473
Necrotising colitis 12.00 9.60 22 421530 1316 90205579
Spondylolysis 11.97 9.60 8 421544 147 90206748
Atrial rupture 11.97 9.60 6 421546 62 90206833
Oral blood blister 11.97 9.60 6 421546 62 90206833
Injury associated with device 11.96 9.60 3 421549 4461 90202434
Acute febrile neutrophilic dermatosis 11.94 9.60 40 421512 3505 90203390
Partial seizures with secondary generalisation 11.94 9.60 13 421539 476 90206419
Fluid retention 11.92 9.60 315 421237 87776 90119119
Actinomycosis 11.91 9.60 20 421532 1116 90205779
Ecthyma 11.88 9.60 12 421540 402 90206493
Device deployment issue 11.87 9.60 4 421548 4905 90201990
Nasal disorder 11.85 9.60 38 421514 3254 90203641
Menstruation irregular 11.82 9.60 12 421540 8048 90198847
Rash scarlatiniform 11.81 9.60 9 421543 205 90206690
Dysphagia 11.79 9.60 637 420915 111641 90095254
Urethral cancer 11.77 9.60 4 421548 13 90206882
Large intestine infection 11.77 9.60 33 421519 2624 90204271
Adjusted calcium increased 11.76 9.60 5 421547 34 90206861
Vitamin D deficiency 11.74 9.60 42 421510 17514 90189381
Cerebral fungal infection 11.72 9.60 10 421542 269 90206626
Human herpesvirus 7 infection 11.70 9.60 8 421544 153 90206742
Cerebral disorder 11.68 9.60 55 421497 5639 90201256
JC virus CSF test positive 11.64 9.60 5 421547 35 90206860
Hydronephrosis 11.62 9.60 98 421454 12304 90194591
Infusion site streaking 11.62 9.60 14 421538 573 90206322
Papillary cystadenoma lymphomatosum 11.61 9.60 8 421544 155 90206740
Oral fungal infection 11.58 9.60 38 421514 3294 90203601
Vitreous haze 11.57 9.60 6 421546 67 90206828
Ankle fracture 11.55 9.60 52 421500 20318 90186577
Bone neoplasm 11.51 9.60 17 421535 849 90206046
Hypersensitivity myocarditis 11.50 9.60 10 421542 276 90206619
Vertebral lesion 11.50 9.60 16 421536 756 90206139
Herpes simplex meningitis 11.49 9.60 6 421546 68 90206827
Creatinine renal clearance decreased 11.48 9.60 47 421505 18852 90188043
Hepatocellular injury 11.48 9.60 194 421358 28764 90178131
Hyperammonaemia 11.47 9.60 60 421492 6415 90200480
Blood glucose decreased 11.46 9.60 63 421489 23366 90183529
Pyomyositis 11.43 9.60 12 421540 421 90206474
Orbital infection 11.42 9.60 7 421545 110 90206785
Hepatic infarction 11.41 9.60 15 421537 671 90206224
Spinal osteoarthritis 11.40 9.60 48 421504 19100 90187795
Blood immunoglobulin A increased 11.39 9.60 21 421531 1262 90205633
Dacryostenosis acquired 11.39 9.60 16 421536 763 90206132
Neonatal respiratory distress 11.36 9.60 15 421537 674 90206221
Retinal haemorrhage 11.33 9.60 55 421497 5709 90201186
Venous oxygen saturation increased 11.29 9.60 5 421547 38 90206857
Mediastinal effusion 11.27 9.60 6 421546 71 90206824
Abortion induced 11.27 9.60 24 421528 11864 90195031
Corneal infiltrates 11.26 9.60 8 421544 163 90206732
Fungal oesophagitis 11.23 9.60 16 421536 773 90206122
Inflammatory bowel disease 11.20 9.60 5 421547 5166 90201729
Tracheal injury 11.18 9.60 8 421544 165 90206730
Sudden cardiac death 11.17 9.60 29 421523 2203 90204692
Haemophilus infection 11.14 9.60 22 421530 1392 90205503
Leukaemoid reaction 11.14 9.60 9 421543 224 90206671
Myopathy toxic 11.11 9.60 14 421538 600 90206295
Embedded device 11.11 9.60 3 421549 4245 90202650
Application site pruritus 11.10 9.60 3 421549 4244 90202651
Ligament sprain 11.09 9.60 33 421519 14566 90192329
Hepatic function abnormal 11.09 9.60 288 421264 46000 90160895
Soft tissue atrophy 11.08 9.60 5 421547 40 90206855
Hypoproteinaemia 11.07 9.60 36 421516 3106 90203789
Atrial thrombosis 11.06 9.60 29 421523 2216 90204679
Iridocele 11.06 9.60 3 421549 3 90206892
Radiotherapy to brain 11.06 9.60 3 421549 3 90206892
Plasma cells present 11.06 9.60 3 421549 3 90206892
Kernicterus 11.06 9.60 3 421549 3 90206892
Oedema 11.06 9.60 792 420760 199503 90007392
Hypothyroidism 11.06 9.60 177 421375 52950 90153945
Corneal graft rejection 11.05 9.60 6 421546 74 90206821
Non-cardiac chest pain 11.04 9.60 61 421491 6660 90200235
Atrioventricular block first degree 11.04 9.60 14 421538 8497 90198398
Crepitations 11.03 9.60 15 421537 8837 90198058
Injection site discomfort 11.02 9.60 7 421545 5933 90200962
Cachexia 11.02 9.60 62 421490 6816 90200079
Naevus haemorrhage 11.00 9.60 7 421545 118 90206777
Anterior chamber flare 11.00 9.60 7 421545 118 90206777
Sacroiliitis 10.99 9.60 3 421549 4216 90202679
Retinal vasculitis 10.98 9.60 23 421529 1518 90205377
Meningism 10.98 9.60 13 421539 522 90206373
Pulmonary infarction 10.98 9.60 34 421518 2858 90204037
Acute coronary syndrome 10.97 9.60 87 421465 10726 90196169
Lens dislocation 10.97 9.60 5 421547 41 90206854
Dysmenorrhoea 10.96 9.60 4 421548 4668 90202227
Post procedural diarrhoea 10.95 9.60 11 421541 366 90206529
Gastrointestinal amyloidosis 10.92 9.60 6 421546 76 90206819
Iris disorder 10.92 9.60 6 421546 76 90206819
Hyponatraemia 10.90 9.60 741 420811 132797 90074098
Injection site phlebitis 10.90 9.60 7 421545 120 90206775
Product availability issue 10.89 9.60 11 421541 7393 90199502
Mesenteric haemorrhage 10.87 9.60 5 421547 42 90206853
Toxoplasmosis 10.86 9.60 25 421527 1760 90205135
Lung consolidation 10.86 9.60 48 421504 4792 90202103
Dyskinesia 10.83 9.60 113 421439 36421 90170474
Infusion site pain 10.83 9.60 51 421501 19687 90187208
Complication associated with device 10.82 9.60 50 421502 19399 90187496
Sensitisation 10.82 9.60 3 421549 4172 90202723
Morganella infection 10.82 9.60 16 421536 800 90206095
CNS ventriculitis 10.80 9.60 9 421543 234 90206661
Oropharyngeal candidiasis 10.78 9.60 20 421532 1208 90205687
Endometrial adenocarcinoma 10.76 9.60 22 421530 1428 90205467
Pneumonia mycoplasmal 10.72 9.60 18 421534 1004 90205891
Disseminated blastomycosis 10.71 9.60 6 421546 79 90206816
VIth nerve paresis 10.71 9.60 6 421546 79 90206816
Gingival swelling 10.71 9.60 49 421503 4964 90201931
Wrist fracture 10.70 9.60 37 421515 15587 90191308
Clostridium colitis 10.68 9.60 27 421525 2018 90204877
Fibrin D dimer increased 10.66 9.60 52 421500 5408 90201487
Ocular lymphoma 10.65 9.60 7 421545 125 90206770
Acute lymphocytic leukaemia refractory 10.65 9.60 6 421546 80 90206815
Catheter site injury 10.64 9.60 10 421542 306 90206589
Vena cava thrombosis 10.63 9.60 31 421521 2521 90204374
Large intestine polyp 10.63 9.60 17 421535 9369 90197526
Posterior capsule rupture 10.60 9.60 3 421549 4 90206891
Oropharyngeal squamous cell carcinoma 10.60 9.60 3 421549 4 90206891
Dexamethasone suppression test positive 10.60 9.60 3 421549 4 90206891
Autologous haematopoietic stem cell transplant 10.59 9.60 4 421548 19 90206876
Renal replacement therapy 10.58 9.60 6 421546 81 90206814
Oxygen saturation 10.58 9.60 9 421543 241 90206654
Post procedural complication 10.57 9.60 49 421503 18993 90187902
Pruritus genital 10.53 9.60 4 421548 4554 90202341
Picornavirus infection 10.52 9.60 6 421546 82 90206813
Malignant pleural effusion 10.48 9.60 34 421518 2930 90203965
Tongue coated 10.43 9.60 24 421528 1689 90205206
Bradyphrenia 10.42 9.60 12 421540 7600 90199295
Blood immunoglobulin G increased 10.42 9.60 34 421518 2938 90203957
Bone marrow necrosis 10.41 9.60 7 421545 130 90206765
Drug effect less than expected 10.37 9.60 8 421544 6130 90200765
Recurrent cancer 10.37 9.60 30 421522 2429 90204466
Emphysematous cystitis 10.35 9.60 10 421542 317 90206578
Gestational diabetes 10.33 9.60 21 421531 10561 90196334
Therapeutic response delayed 10.32 9.60 16 421536 834 90206061
Herpes simplex sepsis 10.30 9.60 5 421547 48 90206847
Tessellated fundus 10.30 9.60 5 421547 48 90206847
Cystitis 10.28 9.60 234 421318 66484 90140411
Bacterial translocation 10.28 9.60 15 421537 741 90206154
Tachycardia foetal 10.25 9.60 8 421544 189 90206706
Gamma-glutamyltransferase increased 10.25 9.60 240 421312 37712 90169183
Uterine leiomyoma 10.24 9.60 22 421530 10842 90196053
Autoimmune disorder 10.24 9.60 275 421277 76469 90130426
Otitis media acute 10.23 9.60 19 421533 1148 90205747
Eye pruritus 10.23 9.60 86 421466 28941 90177954
Frustration tolerance decreased 10.23 9.60 13 421539 7883 90199012
Enterobacter sepsis 10.23 9.60 10 421542 322 90206573
Encephalitis fungal 10.21 9.60 6 421546 87 90206808
Blood iron abnormal 10.21 9.60 3 421549 4017 90202878
Ichthyosis acquired 10.21 9.60 3 421549 5 90206890
Keratitis bacterial 10.21 9.60 5 421547 49 90206846
Bundle branch block left 10.19 9.60 13 421539 7872 90199023
Mean cell haemoglobin decreased 10.17 9.60 7 421545 5688 90201207
Lung adenocarcinoma 10.16 9.60 52 421500 5513 90201382
Disinhibition 10.14 9.60 18 421534 1050 90205845
Inflammatory marker increased 10.14 9.60 17 421535 9197 90197698
Aborted pregnancy 10.12 9.60 5 421547 50 90206845
Parasitic encephalitis 10.12 9.60 5 421547 50 90206845
Tension headache 10.11 9.60 12 421540 7497 90199398
Diverticulitis intestinal perforated 10.09 9.60 11 421541 403 90206492
Reflux gastritis 10.06 9.60 21 421531 1383 90205512
Toxic skin eruption 10.05 9.60 115 421437 15659 90191236
Crohn's disease 10.03 9.60 5 421547 4846 90202049
Cholecystitis chronic 10.03 9.60 19 421533 9807 90197088
Gaze palsy 10.00 9.60 23 421529 1618 90205277
Cytomegalovirus enterocolitis 9.99 9.60 16 421536 858 90206037
Tongue oedema 9.98 9.60 51 421501 5403 90201492
Mental disorder 9.98 9.60 99 421453 32219 90174676
Coating in mouth 9.97 9.60 8 421544 197 90206698
Anterior segment ischaemia 9.95 9.60 5 421547 52 90206843
Tenosynovitis stenosans 9.95 9.60 3 421549 3950 90202945
Ulcerative keratitis 9.94 9.60 37 421515 3416 90203479
Herpes zoster reactivation 9.90 9.60 8 421544 199 90206696
Lumbar vertebral fracture 9.89 9.60 64 421488 7394 90199501
Central nervous system lesion 9.86 9.60 90 421462 11556 90195339
Epstein Barr virus positive mucocutaneous ulcer 9.86 9.60 13 421539 583 90206312
Hepatic vascular thrombosis 9.86 9.60 3 421549 6 90206889
Crowned dens syndrome 9.86 9.60 3 421549 6 90206889
Encephalitis protozoal 9.86 9.60 3 421549 6 90206889
Serology abnormal 9.86 9.60 3 421549 6 90206889
Dacryocanaliculitis 9.86 9.60 3 421549 6 90206889
Portal vein occlusion 9.83 9.60 4 421548 24 90206871
Cell-mediated cytotoxicity 9.83 9.60 4 421548 24 90206871
Upper respiratory tract infection 9.82 9.60 492 421060 127826 90079069
Portal vein embolism 9.81 9.60 6 421546 94 90206801
Pleuroparenchymal fibroelastosis 9.80 9.60 8 421544 202 90206693
Pneumonia klebsiella 9.76 9.60 34 421518 3038 90203857
Chest pain 9.76 9.60 1320 420232 318325 89888570
Splenic abscess 9.76 9.60 9 421543 269 90206626
Hyperuricaemia 9.74 9.60 59 421493 6660 90200235
Serotonin syndrome 9.74 9.60 121 421431 37766 90169129
Impaired driving ability 9.73 9.60 6 421546 5167 90201728
Central nervous system fungal infection 9.71 9.60 7 421545 146 90206749
Stenotrophomonas test positive 9.69 9.60 4 421548 25 90206870
Corneal epithelial microcysts 9.69 9.60 4 421548 25 90206870
Mouth ulceration 9.66 9.60 249 421303 39725 90167170
Dactylitis 9.64 9.60 3 421549 3870 90203025
Cystitis escherichia 9.62 9.60 14 421538 690 90206205
Coordination abnormal 9.60 9.60 59 421493 21297 90185598

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2652.67 12.00 2629 368016 44949 42205741
Neuropathy peripheral 1638.25 12.00 3070 367575 98783 42151907
Neutropenia 1514.24 12.00 4478 366167 194953 42055737
Thrombocytopenia 1285.75 12.00 4103 366542 186176 42064514
Febrile neutropenia 1213.45 12.00 3959 366686 181744 42068946
Pneumonia 1051.94 12.00 6761 363884 415388 41835302
Disease progression 929.64 12.00 3054 367591 140602 42110088
Off label use 874.54 12.00 8914 361731 629421 41621269
Plasma cell myeloma recurrent 861.99 12.00 568 370077 5189 42245501
Completed suicide 706.52 12.00 31 370614 96434 42154256
Drug abuse 637.44 12.00 80 370565 104691 42145999
Drug interaction 596.78 12.00 874 369771 266125 41984565
Platelet count decreased 516.35 12.00 2479 368166 136102 42114588
Pancytopenia 509.16 12.00 2201 368444 115542 42135148
Deep vein thrombosis 430.54 12.00 1560 369085 75397 42175293
Unevaluable event 427.73 12.00 931 369714 33357 42217333
Intentional overdose 420.27 12.00 5 370640 51451 42199239
Plasmacytoma 404.58 12.00 322 370323 4042 42246648
Overdose 396.90 12.00 210 370435 105054 42145636
Polyneuropathy 365.59 12.00 614 370031 18047 42232643
Cytopenia 364.70 12.00 592 370053 16905 42233785
Septic shock 344.79 12.00 1645 369000 90027 42160663
Therapy partial responder 344.35 12.00 622 370023 19399 42231291
White blood cell count decreased 341.29 12.00 1875 368770 108521 42142169
Full blood count decreased 318.88 12.00 611 370034 19949 42230741
Arthralgia 318.26 12.00 833 369812 204405 42046285
Tumour lysis syndrome 311.38 12.00 633 370012 21598 42229092
Cytokine release syndrome 308.44 12.00 970 369675 43557 42207133
Injection site pain 304.93 12.00 65 370580 57733 42192957
Fatigue 296.37 12.00 5373 365272 430268 41820422
Sepsis 296.20 12.00 2838 367807 196496 42054194
Inappropriate schedule of product administration 290.57 12.00 244 370401 95658 42155032
Neutropenic sepsis 272.44 12.00 494 370151 15452 42235238
Suicide attempt 271.20 12.00 39 370606 46061 42204629
Rheumatoid arthritis 261.44 12.00 31 370614 42409 42208281
Suicidal ideation 260.62 12.00 51 370594 48110 42202580
Rhabdomyolysis 259.97 12.00 180 370465 77839 42172851
Pneumocystis jirovecii pneumonia 251.79 12.00 627 370018 24554 42226136
Constipation 242.09 12.00 2313 368332 159978 42090712
Stress 232.64 12.00 50 370595 44162 42206528
Neutrophil count decreased 219.07 12.00 1111 369534 62304 42188386
Psoriasis 218.15 12.00 75 370570 48529 42202161
Depression 215.19 12.00 400 370245 110963 42139727
Loss of personal independence in daily activities 214.89 12.00 82 370563 49734 42200956
Plasma cell myeloma refractory 213.21 12.00 140 370505 1270 42249420
Pyrexia 212.04 12.00 4694 365951 389348 41861342
Endophthalmitis 208.77 12.00 224 370421 4209 42246481
Laboratory test abnormal 203.83 12.00 547 370098 22431 42228259
Mucormycosis 200.79 12.00 278 370367 6865 42243825
Plasma cell leukaemia 197.01 12.00 127 370518 1113 42249577
Pulmonary embolism 194.52 12.00 1737 368908 117875 42132815
Intentional product misuse 194.29 12.00 152 370493 61748 42188942
Death 194.26 12.00 5414 365231 465771 41784919
Drug hypersensitivity 193.78 12.00 355 370290 99034 42151656
Asthma 190.60 12.00 157 370488 62157 42188533
Wrong technique in product usage process 189.26 12.00 67 370578 42568 42208122
Mucosal inflammation 188.38 12.00 890 369755 48484 42202206
Thrombosis 188.19 12.00 1128 369517 67383 42183307
Intraocular pressure increased 187.81 12.00 255 370390 6178 42244512
Anxiety 182.94 12.00 482 370163 118078 42132612
Blood creatine phosphokinase increased 182.73 12.00 96 370549 48242 42202448
Incorrect dose administered 182.12 12.00 118 370527 52856 42197834
Myelodysplastic syndrome 181.53 12.00 521 370124 22224 42228466
COVID-19 pneumonia 178.28 12.00 501 370144 21112 42229578
Leukopenia 177.00 12.00 1185 369460 73561 42177129
Hiccups 176.92 12.00 352 370293 11819 42238871
Osteonecrosis 176.80 12.00 412 370233 15453 42235237
Anaemia 175.41 12.00 3415 367230 276863 41973827
Headache 173.28 12.00 1294 369351 238075 42012615
Bronchopulmonary aspergillosis 170.80 12.00 461 370184 18968 42231722
Somnolence 166.43 12.00 647 369998 140458 42110232
Sedation 165.44 12.00 32 370613 30443 42220247
Light chain analysis increased 162.09 12.00 131 370514 1683 42249007
Peripheral sensory neuropathy 159.37 12.00 279 370366 8483 42242207
Rhinocerebral mucormycosis 157.03 12.00 89 370556 601 42250089
Haematotoxicity 154.06 12.00 313 370332 10672 42240018
COVID-19 150.34 12.00 1606 369039 114342 42136348
Strongyloidiasis 148.76 12.00 166 370479 3265 42247425
Infection 147.99 12.00 1558 369087 110510 42140180
Musculoskeletal stiffness 147.22 12.00 171 370474 57594 42193096
Therapy non-responder 146.17 12.00 878 369767 52481 42198209
Complication of device insertion 142.91 12.00 50 370595 74 42250616
Cytomegalovirus chorioretinitis 141.07 12.00 187 370458 4424 42246266
Diarrhoea 140.27 12.00 5107 365538 455742 41794948
Coronary artery disease 140.19 12.00 156 370489 53564 42197126
Diffuse large B-cell lymphoma recurrent 140.10 12.00 192 370453 4694 42245996
Hypoglycaemia 139.18 12.00 190 370455 59664 42191026
Hospitalisation 136.55 12.00 275 370370 74055 42176635
Venoocclusive liver disease 135.62 12.00 286 370359 10016 42240674
Colitis ulcerative 134.87 12.00 31 370614 26144 42224546
Malignant neoplasm progression 134.76 12.00 1489 369156 106911 42143779
Osteonecrosis of jaw 134.63 12.00 418 370227 18631 42232059
Eczema 132.86 12.00 65 370580 34021 42216669
Febrile bone marrow aplasia 132.13 12.00 281 370364 9900 42240790
Psoriatic arthropathy 129.79 12.00 29 370616 24938 42225752
Hyperglycaemia 129.07 12.00 760 369885 45099 42205591
Neuroleptic malignant syndrome 129.03 12.00 17 370628 21455 42229235
Myelosuppression 128.73 12.00 693 369952 39768 42210922
Serotonin syndrome 126.59 12.00 34 370611 25811 42224879
Pain 125.11 12.00 1444 369201 243404 42007286
Aggression 124.55 12.00 120 370525 44043 42206647
Lactic acidosis 124.18 12.00 126 370519 45135 42205555
Disseminated aspergillosis 123.90 12.00 110 370535 1620 42249070
Squamous cell carcinoma of skin 122.10 12.00 312 370333 12414 42238276
Acute lymphocytic leukaemia 120.48 12.00 149 370496 3282 42247408
Myalgia 118.79 12.00 432 370213 95648 42155042
Hallucination 118.77 12.00 198 370447 57309 42193381
Nightmare 118.61 12.00 35 370610 24977 42225713
Diffuse large B-cell lymphoma refractory 117.89 12.00 114 370531 1883 42248807
Haemophagocytic lymphohistiocytosis 115.31 12.00 385 370260 17837 42232853
Bone marrow failure 115.08 12.00 581 370064 32512 42218178
Obstructive airways disorder 114.97 12.00 36 370609 24723 42225967
Coma 114.72 12.00 180 370465 53374 42197316
Hypogammaglobulinaemia 114.58 12.00 292 370353 11599 42239091
Drug dependence 114.13 12.00 55 370590 29039 42221651
Electrocardiogram QT prolonged 113.69 12.00 150 370495 47795 42202895
Accidental overdose 111.98 12.00 53 370592 28277 42222413
Sleep disorder due to a general medical condition 111.93 12.00 11 370634 17442 42233248
Medication error 111.04 12.00 76 370569 33078 42217612
Wheezing 110.02 12.00 192 370453 54589 42196101
Infusion related reaction 108.67 12.00 902 369743 59904 42190786
Cytomegalovirus infection reactivation 108.23 12.00 275 370370 10903 42239787
Angioedema 107.95 12.00 126 370519 42351 42208339
Bacteraemia 107.91 12.00 468 370177 24572 42226118
Drug ineffective for unapproved indication 107.51 12.00 729 369916 45434 42205256
Product prescribing error 106.09 12.00 47 370598 26065 42224625
Hypercalcaemia 105.92 12.00 372 370273 17686 42233004
Blood pressure increased 104.97 12.00 492 370153 101436 42149254
Bone lesion 103.63 12.00 139 370506 3327 42247363
Neurotoxicity 101.89 12.00 442 370203 23209 42227481
Poisoning 100.51 12.00 7 370638 14692 42235998
Lymphopenia 99.89 12.00 412 370233 21151 42229539
Condition aggravated 99.35 12.00 1632 369013 259122 41991568
Myasthenia gravis 98.84 12.00 12 370633 16125 42234565
Synovitis 96.78 12.00 11 370634 15556 42235134
Corneal oedema 96.37 12.00 91 370554 1457 42249233
Hypofibrinogenaemia 95.46 12.00 101 370544 1866 42248824
Drug withdrawal syndrome 95.39 12.00 34 370611 21515 42229175
Multiple sclerosis relapse 94.13 12.00 8 370637 14256 42236434
Disseminated strongyloidiasis 93.80 12.00 58 370587 469 42250221
Myocardial infarction 93.12 12.00 663 369982 123346 42127344
Blood pressure fluctuation 92.38 12.00 60 370585 26848 42223842
Immune effector cell-associated neurotoxicity syndrome 91.85 12.00 233 370412 9228 42241462
Intentional self-injury 91.43 12.00 12 370633 15190 42235500
Blood pressure systolic increased 91.18 12.00 66 370579 27902 42222788
Frequent bowel movements 91.04 12.00 36 370609 21371 42229319
Respiratory tract infection 89.33 12.00 459 370186 25863 42224827
Pruritus 87.72 12.00 1136 369509 187635 42063055
Acute myeloid leukaemia 87.65 12.00 405 370240 21851 42228839
Monoclonal immunoglobulin present 87.56 12.00 77 370568 1119 42249571
Parainfluenzae virus infection 86.65 12.00 131 370514 3512 42247178
Therapeutic response shortened 85.73 12.00 9 370636 13545 42237145
Injection site swelling 85.67 12.00 21 370624 16952 42233738
Osteolysis 85.53 12.00 129 370516 3451 42247239
Cataract 85.33 12.00 506 370139 30098 42220592
Respiratory failure 84.95 12.00 1576 369069 126556 42124134
Ocular hypertension 84.61 12.00 74 370571 1067 42249623
Acute lymphocytic leukaemia recurrent 83.95 12.00 130 370515 3561 42247129
Contraindicated product administered 83.22 12.00 59 370586 25213 42225477
Hyperkalaemia 82.45 12.00 389 370256 80069 42170621
Haematochezia 82.35 12.00 248 370397 58188 42192502
Stomatitis 81.24 12.00 730 369915 49599 42201091
International normalised ratio increased 81.14 12.00 187 370458 47981 42202709
Tooth disorder 80.19 12.00 258 370387 11721 42238969
Arthritis 78.63 12.00 154 370491 41911 42208779
Pathological fracture 78.03 12.00 154 370491 5139 42245551
B-cell type acute leukaemia 77.86 12.00 61 370584 747 42249943
Ageusia 77.73 12.00 250 370395 11355 42239335
Bone pain 77.36 12.00 410 370235 23382 42227308
Dyskinesia 76.34 12.00 65 370580 25325 42225365
Metabolic acidosis 76.04 12.00 216 370429 51642 42199048
Rash 75.99 12.00 3036 367609 273918 41976772
Cardiac murmur 74.67 12.00 11 370634 12764 42237926
Surgery 74.30 12.00 30 370615 17586 42233104
Candida infection 74.14 12.00 378 370267 21232 42229458
Accidental exposure to product 73.44 12.00 43 370602 20350 42230340
Erectile dysfunction 73.43 12.00 65 370580 24848 42225842
Hallucination, visual 73.35 12.00 46 370599 20974 42229716
Product dose omission issue 73.15 12.00 925 369720 153440 42097250
Sleep disorder 73.00 12.00 197 370448 47898 42202792
Neoplasm progression 72.99 12.00 467 370178 28533 42222157
Aspergillus infection 72.10 12.00 301 370344 15536 42235154
Dermatitis atopic 71.77 12.00 11 370634 12393 42238297
Posterior reversible encephalopathy syndrome 71.67 12.00 260 370385 12561 42238129
Sopor 71.36 12.00 14 370631 13188 42237502
Body height decreased 71.27 12.00 128 370517 3972 42246718
Treatment noncompliance 71.21 12.00 137 370508 37535 42213155
Spinal cord compression 71.05 12.00 130 370515 4094 42246596
Dizziness 70.53 12.00 1640 369005 247614 42003076
Respiratory arrest 70.42 12.00 86 370559 28338 42222352
Device leakage 70.03 12.00 5 370640 10280 42240410
Listeriosis 69.45 12.00 73 370572 1338 42249352
Stem cell transplant 69.19 12.00 100 370545 2572 42248118
Sleep apnoea syndrome 69.13 12.00 52 370593 21556 42229134
Visceral leishmaniasis 68.35 12.00 66 370579 1088 42249602
Labelled drug-drug interaction medication error 68.27 12.00 25 370620 15557 42235133
Escherichia sepsis 68.18 12.00 153 370492 5594 42245096
Injection site erythema 68.02 12.00 46 370599 20149 42230541
Pain in extremity 67.85 12.00 912 369733 149692 42100998
Ventricular fibrillation 67.64 12.00 98 370547 30025 42220665
Incorrect route of product administration 67.42 12.00 67 370578 24238 42226452
Product quality issue 66.85 12.00 36 370609 17846 42232844
Eosinophilia 66.33 12.00 115 370530 32784 42217906
Progressive multifocal leukoencephalopathy 66.24 12.00 236 370409 11300 42239390
Blood cholesterol increased 66.15 12.00 81 370564 26660 42224030
Toxicity to various agents 66.12 12.00 1503 369142 227633 42023057
Substance-induced psychotic disorder 66.05 12.00 102 370543 2787 42247903
Intentional product use issue 65.30 12.00 931 369714 70902 42179788
Systemic lupus erythematosus 65.06 12.00 4 370641 9320 42241370
Hepatitis B reactivation 64.85 12.00 131 370514 4447 42246243
Obesity 64.73 12.00 31 370614 16428 42234262
Rectal haemorrhage 64.66 12.00 218 370427 49388 42201302
Bone disorder 64.34 12.00 163 370482 6450 42244240
Swollen tongue 64.27 12.00 54 370591 21177 42229513
Adverse drug reaction 64.05 12.00 550 370095 36884 42213806
Respiratory symptom 63.91 12.00 10 370635 11096 42239594
Bronchiectasis 63.48 12.00 39 370606 17980 42232710
Chest pain 63.18 12.00 844 369801 138686 42112004
Palpitations 62.35 12.00 229 370416 50568 42200122
Respiratory depression 62.19 12.00 44 370601 18824 42231866
Abnormal behaviour 61.43 12.00 84 370561 26367 42224323
Hyperlipidaemia 61.20 12.00 58 370587 21458 42229232
Akathisia 61.08 12.00 9 370636 10442 42240248
Drug level increased 61.06 12.00 83 370562 26117 42224573
Blood lactate dehydrogenase increased 60.79 12.00 412 370233 25669 42225021
Blood phosphorus increased 60.36 12.00 17 370628 12508 42238182
Ventricular tachycardia 60.28 12.00 106 370539 30054 42220636
Pemphigoid 60.24 12.00 13 370632 11454 42239236
Pneumonia influenzal 60.20 12.00 79 370566 1850 42248840
Asthenia 60.05 12.00 3001 367644 277792 41972898
Melaena 59.33 12.00 158 370487 38588 42212102
Injury 59.09 12.00 64 370581 22252 42228438
Large intestine perforation 59.02 12.00 200 370445 9336 42241354
Abdominal discomfort 58.59 12.00 398 370247 74857 42175833
Heart rate decreased 58.22 12.00 146 370499 36386 42214304
Hepatic cirrhosis 57.35 12.00 52 370593 19650 42231040
Arteriosclerosis coronary artery 57.16 12.00 47 370598 18630 42232060
Hypertriglyceridaemia 57.15 12.00 206 370439 9920 42240770
Atrial fibrillation 56.51 12.00 1602 369043 137991 42112699
Myelopathy 56.44 12.00 95 370550 2796 42247894
Multiple organ dysfunction syndrome 56.01 12.00 1169 369476 95866 42154824
Transplant rejection 55.92 12.00 24 370621 13564 42237126
Cushingoid 55.90 12.00 104 370541 3318 42247372
Agitation 55.79 12.00 329 370316 63985 42186705
Extrapyramidal disorder 55.79 12.00 37 370608 16375 42234315
Disseminated cryptococcosis 55.73 12.00 76 370569 1849 42248841
Infective pulmonary exacerbation of cystic fibrosis 55.63 12.00 3 370642 7815 42242875
Pneumonia bacterial 55.60 12.00 277 370368 15415 42235275
Corneal decompensation 55.50 12.00 20 370625 34 42250656
Spinal fracture 55.35 12.00 191 370454 8999 42241691
Embolism 55.30 12.00 185 370460 8578 42242112
Tubulointerstitial nephritis 55.15 12.00 120 370525 31428 42219262
Injection site haemorrhage 54.60 12.00 17 370628 11719 42238971
Systemic candida 53.74 12.00 133 370512 5186 42245504
Impaired work ability 53.65 12.00 19 370626 12072 42238618
Device malfunction 53.63 12.00 20 370625 12307 42238383
Hyperviscosity syndrome 53.45 12.00 33 370612 266 42250424
H1N1 influenza 53.38 12.00 58 370587 1106 42249584
Therapeutic product effect incomplete 53.34 12.00 379 370266 70560 42180130
Bacterial sepsis 53.19 12.00 150 370495 6332 42244358
Product substitution issue 53.16 12.00 16 370629 11274 42239416
Glioblastoma 53.11 12.00 64 370581 1371 42249319
Arteriosclerosis 52.94 12.00 47 370598 17942 42232748
Visual acuity reduced 52.72 12.00 296 370349 17254 42233436
Gastrooesophageal reflux disease 52.65 12.00 207 370438 44816 42205874
Underdose 52.18 12.00 41 370604 16625 42234065
Choroiditis 52 12.00 62 370583 1313 42249377
Miosis 51.85 12.00 26 370619 13420 42237270
Syringe issue 50.87 12.00 7 370638 8549 42242141
Device issue 50.79 12.00 27 370618 13482 42237208
Gynaecomastia 50.45 12.00 23 370622 12544 42238146
Dystonia 50.43 12.00 24 370621 12766 42237924
Microsporidia infection 50.40 12.00 56 370589 1096 42249594
Monoclonal immunoglobulin increased 50.18 12.00 37 370608 411 42250279
Hyperhidrosis 50.00 12.00 524 370121 89988 42160702
Gastrointestinal haemorrhage 49.91 12.00 576 370069 97150 42153540
Adrenal insufficiency 49.64 12.00 308 370337 18616 42232074
Autonomic neuropathy 49.63 12.00 53 370592 990 42249700
Primary amyloidosis 49.29 12.00 29 370616 212 42250478
Substance abuse 49.08 12.00 9 370636 8896 42241794
Injection site reaction 48.81 12.00 39 370606 15682 42235008
Dry mouth 48.79 12.00 180 370465 39699 42210991
Benign prostatic hyperplasia 48.74 12.00 67 370578 20985 42229705
Injection site pruritus 48.73 12.00 11 370634 9394 42241296
Anaphylactic shock 48.69 12.00 361 370284 23156 42227534
Influenza 48.45 12.00 785 369860 61390 42189300
Glycosylated haemoglobin increased 48.34 12.00 26 370619 12898 42237792
B precursor type acute leukaemia 48.31 12.00 29 370616 221 42250469
Amyloidosis 47.90 12.00 80 370565 2339 42248351
Abdominal pain 47.66 12.00 1276 369369 189195 42061495
Pulmonary mucormycosis 47.61 12.00 61 370584 1394 42249296
Chronic obstructive pulmonary disease 47.54 12.00 337 370308 62777 42187913
Minimal residual disease 47.51 12.00 41 370604 580 42250110
Activated partial thromboplastin time prolonged 47.46 12.00 41 370604 15862 42234828
Fear 47.35 12.00 18 370627 10947 42239743
Staphylococcal bacteraemia 47.25 12.00 207 370438 10914 42239776
Foetal exposure during pregnancy 47.14 12.00 231 370414 47080 42203610
Pulmonary fibrosis 47.04 12.00 101 370544 26580 42224110
Cardiogenic shock 46.87 12.00 156 370489 35484 42215206
Loss of consciousness 46.52 12.00 546 370099 91808 42158882
Injection site bruising 46.41 12.00 21 370624 11504 42239186
Cataract subcapsular 46.23 12.00 39 370606 534 42250156
Hypertension 46.16 12.00 1104 369541 166100 42084590
Joint injury 46.08 12.00 36 370609 14640 42236050
Lymphoid tissue hypoplasia 46.05 12.00 47 370598 831 42249859
Hypothyroidism 46.03 12.00 135 370510 31949 42218741
Forced expiratory volume decreased 45.94 12.00 6 370639 7624 42243066
Nephrolithiasis 45.88 12.00 165 370480 36665 42214025
Psychotic disorder 45.56 12.00 118 370527 29090 42221600
Spinal compression fracture 45.48 12.00 156 370489 7327 42243363
Product storage error 45.33 12.00 20 370625 11120 42239570
Fall 45.30 12.00 1626 369019 232894 42017796
Delusion 45.18 12.00 37 370608 14697 42235993
Escherichia bacteraemia 45.07 12.00 122 370523 5027 42245663
Muscle spasms 44.99 12.00 1022 369623 85022 42165668
Thymus hypoplasia 44.95 12.00 46 370599 816 42249874
Panic attack 44.68 12.00 20 370625 11025 42239665
Impaired quality of life 44.23 12.00 35 370610 14142 42236548
Pseudomonas infection 44.21 12.00 263 370382 15660 42235030
Intercepted product preparation error 44.03 12.00 6 370639 7383 42243307
Full blood count increased 43.94 12.00 49 370596 963 42249727
Hallucination, auditory 43.54 12.00 39 370606 14825 42235865
Neutropenic colitis 43.30 12.00 110 370535 4360 42246330
Therapeutic product effect decreased 43.27 12.00 184 370461 38966 42211724
Blood immunoglobulin M decreased 42.98 12.00 45 370600 821 42249869
Product administration error 42.85 12.00 58 370587 18285 42232405
Tardive dyskinesia 42.78 12.00 5 370640 6919 42243771
Injection site mass 42.52 12.00 11 370634 8564 42242126
Febrile infection 42.52 12.00 82 370563 2689 42248001
Immunosuppressant drug level increased 42.21 12.00 8 370637 7723 42242967
Paranoia 42.05 12.00 36 370609 13990 42236700
C-reactive protein abnormal 42.05 12.00 14 370631 9247 42241443
Parkinsonism 41.78 12.00 20 370625 10603 42240087
Migraine 41.72 12.00 100 370545 25314 42225376
Red blood cell sedimentation rate increased 41.69 12.00 17 370628 9907 42240783
Bradycardia 41.67 12.00 509 370136 84975 42165715
Sexual dysfunction 41.59 12.00 5 370640 6770 42243920
Keratopathy 41.49 12.00 40 370605 658 42250032
Lower respiratory tract infection 41.49 12.00 544 370101 40662 42210028
Ankylosing spondylitis 41.42 12.00 6 370639 7050 42243640
Atypical haemolytic uraemic syndrome 40.94 12.00 36 370609 523 42250167
Pneumonia pneumococcal 40.37 12.00 77 370568 2504 42248186
Prescribed overdose 40.22 12.00 32 370613 12895 42237795
Muscle rigidity 39.90 12.00 28 370617 12031 42238659
Peripheral motor neuropathy 39.76 12.00 71 370574 2193 42248497
Drug dose omission by device 39.68 12.00 3 370642 5883 42244807
Blood immunoglobulin A decreased 39.57 12.00 39 370606 660 42250030
Heart block congenital 39.55 12.00 16 370629 43 42250647
Pneumonia fungal 39.44 12.00 171 370474 8975 42241715
Osteoarthritis 39.30 12.00 97 370548 24308 42226382
Paraproteinaemia 39.02 12.00 31 370614 388 42250302
Disseminated mucormycosis 38.89 12.00 54 370591 1337 42249353
Bladder cancer 38.72 12.00 55 370590 16992 42233698
Gait disturbance 38.66 12.00 609 370036 97391 42153299
Swelling 38.50 12.00 299 370346 54586 42196104
Emotional distress 38.50 12.00 50 370595 16043 42234647
Cytomegalovirus infection 38.37 12.00 440 370205 31866 42218824
Pseudomyopia 38.11 12.00 18 370627 78 42250612
Cholestasis 37.91 12.00 152 370493 32727 42217963
Adenocarcinoma of colon 37.61 12.00 95 370550 3752 42246938
Micturition urgency 37.59 12.00 29 370616 11869 42238821
Disease recurrence 37.43 12.00 409 370236 29269 42221421
Neuritis 37.19 12.00 5 370640 6215 42244475
Paraplegia 37.14 12.00 86 370559 3211 42247479
Normochromic normocytic anaemia 37.09 12.00 16 370629 9015 42241675
Salivary hypersecretion 36.75 12.00 25 370620 10918 42239772
Malignant neoplasm of unknown primary site 36.70 12.00 30 370615 392 42250298
Dyslipidaemia 36.63 12.00 18 370627 9400 42241290
Steroid dependence 36.60 12.00 7 370638 6715 42243975
Hypertransaminasaemia 36.39 12.00 168 370477 9059 42241631
Kidney transplant rejection 36.27 12.00 15 370630 8668 42242022
Clostridium difficile colitis 36.22 12.00 312 370333 20940 42229750
Iron deficiency anaemia 36.10 12.00 36 370609 13003 42237687
Drug level decreased 35.98 12.00 21 370624 9956 42240734
JC virus infection 35.66 12.00 80 370565 2924 42247766
Torsade de pointes 35.65 12.00 15 370630 8579 42242111
Pulmonary sepsis 35.59 12.00 85 370560 3239 42247451
Road traffic accident 35.59 12.00 70 370575 19023 42231667
Metastases to central nervous system 35.42 12.00 181 370464 10174 42240516
Therapy interrupted 35.39 12.00 89 370556 22161 42228529
Middle insomnia 35.29 12.00 12 370633 7821 42242869
Leukoencephalopathy 35.27 12.00 109 370536 4845 42245845
Pneumonia escherichia 35.03 12.00 36 370609 642 42250048
Infection reactivation 34.99 12.00 66 370579 2128 42248562
Needle issue 34.99 12.00 16 370629 8711 42241979
Hypercholesterolaemia 34.97 12.00 36 370609 12813 42237877
Refractory anaemia with an excess of blasts 34.84 12.00 27 370618 325 42250365
Discomfort 34.83 12.00 108 370537 25111 42225579
Abdominal distension 34.63 12.00 428 370217 71307 42179383
Herpes zoster 34.56 12.00 502 370143 38375 42212315
Depressed level of consciousness 34.27 12.00 260 370385 47710 42202980
Nodule 34.25 12.00 35 370610 12499 42238191
Meningitis pneumococcal 34.22 12.00 24 370621 245 42250445
Atrial septal defect 34.20 12.00 13 370632 7906 42242784
Blood pressure systolic abnormal 34.13 12.00 4 370641 5524 42245166
Back pain 33.99 12.00 1533 369112 140243 42110447
Hypopnoea 33.94 12.00 13 370632 7869 42242821
Joint swelling 33.92 12.00 403 370242 67619 42183071
Productive cough 33.84 12.00 286 370359 51281 42199409
Mobility decreased 33.68 12.00 175 370470 35131 42215559
Nasal congestion 33.62 12.00 137 370508 29364 42221326
Ulcerative keratitis 33.54 12.00 63 370582 2025 42248665
Cellulitis orbital 33.51 12.00 30 370615 447 42250243
Familial periodic paralysis 33.47 12.00 20 370625 151 42250539
Haematuria 33.40 12.00 331 370314 57468 42193222
Pulmonary function test decreased 33.35 12.00 5 370640 5727 42244963
Type 2 diabetes mellitus 33.34 12.00 69 370576 18402 42232288
Enterocolitis infectious 33.31 12.00 61 370584 1922 42248768
Pneumonia viral 33.22 12.00 97 370548 4177 42246513
Skin striae 33.22 12.00 37 370608 726 42249964
Aplasia 33.04 12.00 105 370540 4738 42245952
Malaise 32.99 12.00 1508 369137 210648 42040042
Pulmonary thrombosis 32.93 12.00 152 370493 8196 42242494
Sputum discoloured 32.90 12.00 24 370621 10108 42240582
Chronic kidney disease 32.83 12.00 258 370387 46983 42203707
Exposure via skin contact 32.77 12.00 3 370642 5035 42245655
Tendonitis 32.70 12.00 23 370622 9871 42240819
Anger 32.65 12.00 39 370606 12979 42237711
Peripheral sensorimotor neuropathy 32.60 12.00 60 370585 1898 42248792
Exposure to toxic agent 32.50 12.00 3 370642 5001 42245689
Diverticular perforation 32.48 12.00 88 370557 3628 42247062
Autologous haematopoietic stem cell transplant 32.45 12.00 17 370628 96 42250594
Anhedonia 32.24 12.00 13 370632 7627 42243063
Compression fracture 32.09 12.00 88 370557 3654 42247036
Blood pressure diastolic abnormal 32.08 12.00 7 370638 6121 42244569
Mantle cell lymphoma recurrent 32.08 12.00 42 370603 981 42249709
Coronary artery occlusion 32.04 12.00 29 370616 10968 42239722
Blood immunoglobulin A increased 32 12.00 28 370617 404 42250286
Joint stiffness 31.90 12.00 36 370609 12286 42238404
Refractory cytopenia with multilineage dysplasia 31.70 12.00 18 370627 122 42250568
Coombs positive haemolytic anaemia 31.66 12.00 46 370599 1189 42249501
Atrial flutter 31.38 12.00 257 370388 16994 42233696
Ascites 31.34 12.00 328 370317 56350 42194340
Troponin increased 31.30 12.00 75 370570 18987 42231703
Tracheobronchitis 31.26 12.00 48 370597 1305 42249385
Iron deficiency 31.24 12.00 30 370615 11031 42239659
Steroid withdrawal syndrome 31.24 12.00 24 370621 285 42250405
Ischaemic cardiomyopathy 31.15 12.00 9 370636 6513 42244177
Pseudomonal bacteraemia 30.94 12.00 66 370579 2330 42248360
Mydriasis 30.86 12.00 19 370626 8751 42241939
Cardiac failure congestive 30.80 12.00 541 370104 85061 42165629
Euglycaemic diabetic ketoacidosis 30.60 12.00 6 370639 5654 42245036
Intestinal perforation 30.44 12.00 180 370465 10694 42239996
Drug level above therapeutic 30.41 12.00 7 370638 5899 42244791
Complications of transplanted kidney 30.37 12.00 5 370640 5345 42245345
Depressed mood 30.30 12.00 103 370542 23281 42227409
Mitral valve incompetence 30.26 12.00 61 370584 16428 42234262
Skin exfoliation 30.26 12.00 224 370421 41329 42209361
Aeromonas infection 30.07 12.00 25 370620 335 42250355
Taste disorder 29.90 12.00 171 370474 10036 42240654
Joint range of motion decreased 29.88 12.00 15 370630 7738 42242952
Second primary malignancy 29.76 12.00 163 370482 9412 42241278
Vertebral lesion 29.65 12.00 21 370624 218 42250472
Hyponatraemia 29.63 12.00 664 369981 100798 42149892
Cellulitis enterococcal 29.62 12.00 16 370629 97 42250593
Cardiac failure chronic 29.58 12.00 24 370621 9577 42241113
Product dose omission in error 29.54 12.00 18 370627 8336 42242354
Eosinophil count increased 29.47 12.00 30 370615 10733 42239957
Exposure during pregnancy 29.42 12.00 19 370626 8529 42242161
Tricuspid valve incompetence 29.28 12.00 32 370613 11081 42239609
Acute respiratory distress syndrome 29.28 12.00 395 370250 29713 42220977
Oral candidiasis 29.18 12.00 220 370425 14185 42236505
Blood loss anaemia 29.18 12.00 25 370620 9711 42240979
Cardiomegaly 29.12 12.00 64 370581 16702 42233988
Catarrh 29.08 12.00 8 370637 5978 42244712
Blood triglycerides increased 29.01 12.00 59 370586 15837 42234853
Light chain disease 28.96 12.00 18 370627 147 42250543
Meningitis cryptococcal 28.95 12.00 78 370567 3205 42247485
Implantation complication 28.90 12.00 10 370635 14 42250676
Klebsiella infection 28.83 12.00 183 370462 11149 42239541
Hypopyon 28.72 12.00 29 370616 506 42250184
Pneumonia cryptococcal 28.71 12.00 49 370596 1459 42249231
Hypoalbuminaemia 28.64 12.00 233 370412 15377 42235313
Vertigo 28.57 12.00 178 370467 34169 42216521
Blood immunoglobulin G increased 28.50 12.00 42 370603 1100 42249590
Pasteurella infection 28.48 12.00 16 370629 106 42250584
Crying 28.45 12.00 10 370635 6384 42244306
Memory impairment 28.44 12.00 289 370356 49933 42200757
Negative pressure pulmonary oedema 28.41 12.00 31 370614 594 42250096
Vanishing bile duct syndrome 28.26 12.00 55 370590 1816 42248874
Meningitis listeria 28.26 12.00 32 370613 640 42250050
Blood uric acid increased 28.12 12.00 58 370587 15489 42235201
Metapneumovirus infection 28.11 12.00 43 370602 1165 42249525
B-cell lymphoma recurrent 27.99 12.00 36 370609 826 42249864
Fibrinous bronchitis 27.88 12.00 16 370629 111 42250579
Guillain-Barre syndrome 27.73 12.00 131 370514 7132 42243558
Obsessive-compulsive disorder 27.60 12.00 12 370633 6731 42243959
Pneumonitis 27.55 12.00 513 370132 41205 42209485
Product administration interrupted 27.41 12.00 5 370640 4961 42245729
Viral haemorrhagic cystitis 27.40 12.00 54 370591 1800 42248890
Necrotising retinitis 27.33 12.00 39 370606 991 42249699
Blood potassium increased 27.32 12.00 77 370568 18459 42232231
Herpes simplex reactivation 27.26 12.00 28 370617 499 42250191
Hydrocephalus 27.26 12.00 115 370530 5963 42244727
Peritonitis bacterial 27.23 12.00 13 370632 6902 42243788
Coronary artery stenosis 27.22 12.00 30 370615 10349 42240341
Basal cell carcinoma 27.17 12.00 310 370335 22423 42228267
Rectal adenocarcinoma 27.15 12.00 38 370607 948 42249742
Disturbance in attention 26.85 12.00 151 370494 29715 42220975
Ureteric compression 26.82 12.00 22 370623 289 42250401
Enterococcal infection 26.76 12.00 188 370457 11851 42238839
Ecthyma 26.72 12.00 31 370614 637 42250053
Choroidal detachment 26.69 12.00 28 370617 512 42250178
Platelet count abnormal 26.64 12.00 81 370564 3568 42247122
Protein total increased 26.61 12.00 65 370580 2513 42248177
Steroid diabetes 26.41 12.00 69 370576 2783 42247907
Central nervous system vasculitis 26.34 12.00 30 370615 604 42250086
Faeces discoloured 26.33 12.00 69 370576 16945 42233745
Electrocardiogram QRS complex prolonged 26.09 12.00 9 370636 5814 42244876
Pallor 25.99 12.00 146 370499 28740 42221950
Staphylococcal infection 25.95 12.00 466 370179 37177 42213513
Mental disorder 25.76 12.00 76 370569 17953 42232737
Eye pruritus 25.74 12.00 37 370608 11375 42239315
Hyperphosphataemia 25.72 12.00 46 370599 12958 42237732
Breath sounds abnormal 25.55 12.00 41 370604 12052 42238638
Flushing 25.39 12.00 458 370187 36570 42214120
Insurance issue 25.36 12.00 3 370642 4113 42246577
Pneumonia parainfluenzae viral 25.35 12.00 21 370624 280 42250410
Alpha tumour necrosis factor increased 25.30 12.00 23 370622 350 42250340
Restlessness 25.16 12.00 150 370495 29099 42221591
Muscle spasticity 25.11 12.00 14 370631 6808 42243882
Secondary immunodeficiency 25.09 12.00 34 370611 822 42249868
Bradykinesia 25.06 12.00 8 370637 5428 42245262
Blood pressure diastolic decreased 25.06 12.00 32 370613 10343 42240347
Body temperature decreased 25.04 12.00 55 370590 14358 42236332
Varices oesophageal 24.96 12.00 4 370641 4361 42246329
Performance status decreased 24.94 12.00 94 370551 4626 42246064
Blood pressure decreased 24.88 12.00 357 370288 57975 42192715
Escherichia infection 24.77 12.00 177 370468 11219 42239471
Dehydration 24.65 12.00 1487 369158 140280 42110410
Blood immunoglobulin G decreased 24.59 12.00 59 370586 2255 42248435
Device difficult to use 24.58 12.00 5 370640 4591 42246099
Meningitis bacterial 24.51 12.00 44 370601 1365 42249325
Urticaria 24.41 12.00 475 370170 73561 42177129
Aspiration 24.41 12.00 77 370568 17809 42232881
Decreased appetite 24.38 12.00 1973 368672 191164 42059526
Myoclonus 24.34 12.00 72 370573 16993 42233697
Hypokinesia 24.31 12.00 30 370615 9841 42240849
Neck pain 24.22 12.00 157 370488 29857 42220833
Foot deformity 24.20 12.00 7 370638 5061 42245629
Coronary artery bypass 24.18 12.00 6 370639 4804 42245886
Drug intolerance 24.14 12.00 524 370121 79900 42170790
Pneumonia respiratory syncytial viral 23.95 12.00 44 370601 1390 42249300
Appendicitis 23.95 12.00 95 370550 20518 42230172
Vitamin D deficiency 23.86 12.00 21 370624 8052 42242638
Monocyte chemotactic protein-1 increased 23.61 12.00 22 370623 346 42250344
Acute erythroid leukaemia 23.45 12.00 19 370626 245 42250445
Pneumonia aspiration 23.34 12.00 301 370344 49777 42200913
Streptococcal bacteraemia 23.33 12.00 64 370581 2658 42248032
Weight increased 23.30 12.00 738 369907 107245 42143445
Neoplasm recurrence 23.30 12.00 64 370581 2660 42248030
Nervous system disorder 23.09 12.00 240 370405 16955 42233735
Psychomotor retardation 23.08 12.00 5 370640 4394 42246296
Large intestine polyp 22.98 12.00 28 370617 9237 42241453
Cerebral haematoma 22.94 12.00 10 370635 5600 42245090
Haematoma 22.91 12.00 146 370499 27877 42222813
Dissociation 22.83 12.00 3 370642 3795 42246895
Stent placement 22.81 12.00 9 370636 5351 42245339
Heart rate irregular 22.68 12.00 68 370577 15982 42234708
Metastatic malignant melanoma 22.58 12.00 58 370587 2315 42248375
Tinnitus 22.53 12.00 153 370492 28785 42221905
Renal failure 22.51 12.00 1494 369151 142232 42108458
Poor venous access 22.50 12.00 18 370627 7234 42243456
Bile acid malabsorption 22.46 12.00 14 370631 115 42250575
Renal amyloidosis 22.44 12.00 13 370632 92 42250598
Hypothermia 22.37 12.00 47 370598 12468 42238222
Cardiac amyloidosis 22.26 12.00 52 370593 1953 42248737
Angina pectoris 22.24 12.00 181 370464 32715 42217975
Skin fissures 22.19 12.00 31 370614 9645 42241045
Transient ischaemic attack 22.19 12.00 187 370458 33552 42217138
Vascular pain 22.12 12.00 17 370628 202 42250488
Gallbladder oedema 22.10 12.00 18 370627 234 42250456
Disability 22.10 12.00 12 370633 5921 42244769
Rhinovirus infection 22.08 12.00 114 370531 6434 42244256
Pseudomonal sepsis 21.94 12.00 84 370561 4165 42246525
Cytomegalovirus viraemia 21.88 12.00 160 370485 10217 42240473
Seizure 21.86 12.00 842 369803 119719 42130971
Pulmonary hypertension 21.82 12.00 118 370527 23451 42227239
Human polyomavirus infection 21.79 12.00 40 370605 1263 42249427
Blood glucose decreased 21.75 12.00 58 370587 14161 42236529
Spinal operation 21.73 12.00 5 370640 4215 42246475
Hypotony of eye 21.66 12.00 18 370627 241 42250449
Pneumomediastinum 21.66 12.00 68 370577 3048 42247642
Skin plaque 21.63 12.00 12 370633 5851 42244839
Disorientation 21.61 12.00 207 370438 36182 42214508
Parosmia 21.56 12.00 21 370624 7670 42243020
Lymphadenitis 21.48 12.00 59 370586 2452 42248238
Microangiopathic haemolytic anaemia 21.48 12.00 37 370608 1110 42249580
Neoplasm 21.42 12.00 110 370535 6195 42244495
Hyperglycaemic hyperosmolar nonketotic syndrome 21.39 12.00 45 370600 1573 42249117
Lip swelling 21.39 12.00 89 370556 18964 42231726
Haemorrhage 21.38 12.00 384 370261 60179 42190511
Dyspnoea exertional 21.36 12.00 307 370338 49841 42200849
Expired product administered 21.31 12.00 5 370640 4158 42246532
Neutropenic infection 21.26 12.00 49 370596 1824 42248866
Product dispensing error 21.25 12.00 21 370624 7618 42243072
Blood pressure measurement 21.25 12.00 16 370629 184 42250506
Renal cyst 21.24 12.00 34 370611 10005 42240685
Candida pneumonia 21.21 12.00 30 370615 756 42249934
Immunosuppression 21.19 12.00 136 370509 8317 42242373
Diabetes mellitus inadequate control 21.18 12.00 66 370579 15324 42235366
Necrotising fasciitis 21.16 12.00 87 370558 4459 42246231
Blood creatinine increased 21.12 12.00 763 369882 109240 42141450
Pulmonary arterial hypertension 21.09 12.00 35 370610 10152 42240538
Hepatitis cholestatic 21.05 12.00 33 370612 9791 42240899
Depressive symptom 21.01 12.00 4 370641 3849 42246841
Product complaint 20.96 12.00 13 370632 5964 42244726
Hepatic cytolysis 20.86 12.00 142 370503 26702 42223988
Gastrointestinal toxicity 20.82 12.00 79 370566 3900 42246790
Epstein-Barr virus infection reactivation 20.78 12.00 60 370585 2567 42248123
Head injury 20.78 12.00 100 370545 20482 42230208
Intraocular pressure decreased 20.70 12.00 12 370633 85 42250605
Hepatic steatosis 20.63 12.00 106 370539 21342 42229348
Pancreatitis 20.56 12.00 259 370386 43009 42207681
Blood immunoglobulin M increased 20.56 12.00 18 370627 260 42250430
Platelet disorder 20.54 12.00 53 370592 2121 42248569
Fungal infection 20.53 12.00 262 370383 19460 42231230
Abnormal dreams 20.51 12.00 25 370620 8246 42242444
Mucosal haemorrhage 20.51 12.00 47 370598 1743 42248947
Haematemesis 20.48 12.00 166 370479 30033 42220657
Alcohol abuse 20.45 12.00 5 370640 4044 42246646
Cryptococcosis 20.45 12.00 68 370577 3143 42247547
Injection site induration 20.39 12.00 3 370642 3484 42247206
Umbilical hernia 20.31 12.00 11 370634 5436 42245254
Dysentery 20.31 12.00 22 370623 418 42250272
Heart rate increased 20.30 12.00 333 370312 52922 42197768
Weight decreased 20.28 12.00 1545 369100 206403 42044287
Acute kidney injury 20.25 12.00 2843 367802 364494 41886196
Respiratory rate increased 20.24 12.00 41 370604 11021 42239669
Enterococcal bacteraemia 20.23 12.00 60 370585 2607 42248083
Taeniasis 20.21 12.00 10 370635 49 42250641
Light chain analysis abnormal 20.20 12.00 14 370631 140 42250550
Aplastic anaemia 20.16 12.00 180 370465 12204 42238486
Blood urea increased 20.13 12.00 185 370460 32608 42218082
Autoimmune lymphoproliferative syndrome 20.09 12.00 16 370629 201 42250489
Electrocardiogram abnormal 19.96 12.00 36 370609 10109 42240581
Oral pain 19.95 12.00 182 370463 12414 42238276
Status epilepticus 19.93 12.00 69 370576 15509 42235181
Actinomycosis 19.93 12.00 25 370620 559 42250131
Immunoglobulins increased 19.83 12.00 16 370629 205 42250485
Keratitis fungal 19.83 12.00 16 370629 205 42250485
Respiratory tract infection viral 19.83 12.00 70 370575 3336 42247354
Cerebral haemorrhage 19.75 12.00 230 370415 38736 42211954
Thrombotic microangiopathy 19.70 12.00 206 370439 14576 42236114
IVth nerve paralysis 19.69 12.00 25 370620 566 42250124
Cerebral toxoplasmosis 19.67 12.00 51 370594 2047 42248643
Fungaemia 19.61 12.00 66 370579 3070 42247620
Cerebrovascular accident 19.55 12.00 670 369975 96490 42154200
Papilloedema 19.53 12.00 68 370577 3218 42247472
Tuberculosis of central nervous system 19.52 12.00 16 370629 210 42250480
Acinetobacter bacteraemia 19.40 12.00 15 370630 180 42250510
Vasculitis 19.38 12.00 88 370557 18306 42232384
Human herpesvirus 6 encephalitis 19.36 12.00 25 370620 576 42250114
Liver function test abnormal 19.34 12.00 184 370461 32207 42218483
Cardiac arrest 19.27 12.00 766 369879 108554 42142136
Body tinea 19.26 12.00 15 370630 182 42250508
Malignant syphilis 19.24 12.00 9 370636 38 42250652
Hypothalamic pituitary adrenal axis suppression 19.22 12.00 18 370627 285 42250405
Staphylococcal sepsis 19.15 12.00 167 370478 11247 42239443
Cardio-respiratory arrest 19.09 12.00 377 370268 58259 42192431
Colorectal cancer 19.04 12.00 10 370635 5028 42245662
Blood stem cell transplant failure 19.00 12.00 22 370623 451 42250239
Vitreous loss 18.93 12.00 6 370639 5 42250685
Dry skin 18.84 12.00 301 370344 48037 42202653
Clostridium difficile infection 18.74 12.00 289 370356 22370 42228320
Immune-mediated myositis 18.55 12.00 5 370640 3788 42246902
Intentional dose omission 18.49 12.00 31 370614 8955 42241735
Thinking abnormal 18.45 12.00 21 370624 7140 42243550
Cystitis haemorrhagic 18.42 12.00 118 370527 7211 42243479
Oroantral fistula 18.41 12.00 15 370630 195 42250495
Encephalitis brain stem 18.38 12.00 14 370631 164 42250526
Gastric perforation 18.38 12.00 64 370581 3029 42247661
Knee arthroplasty 18.34 12.00 30 370615 8751 42241939
Nephrogenic systemic fibrosis 18.33 12.00 4 370641 3497 42247193
Pneumonia streptococcal 18.30 12.00 44 370601 1684 42249006
Drug specific antibody present 18.29 12.00 6 370639 4000 42246690
Protein total abnormal 18.26 12.00 20 370625 385 42250305
Precursor B-lymphoblastic lymphoma 18.24 12.00 8 370637 28 42250662
Renal cancer 18.22 12.00 27 370618 8197 42242493
Abdominal pain upper 18.20 12.00 563 370082 82046 42168644
Antithrombin III deficiency 18.19 12.00 13 370632 137 42250553
Lung disorder 18.16 12.00 300 370345 47623 42203067
Myocardial ischaemia 18.11 12.00 86 370559 17676 42233014
Hiatus hernia 18.10 12.00 29 370616 8531 42242159
Unintentional medical device removal 18.08 12.00 3 370642 3188 42247502
Snoring 18.05 12.00 6 370639 3967 42246723
Diabetic ketoacidosis 18.05 12.00 117 370528 22250 42228440
Post procedural complication 18.04 12.00 53 370592 12537 42238153
C-reactive protein increased 17.97 12.00 418 370227 63142 42187548
Carotid artery occlusion 17.92 12.00 7 370638 4187 42246503
Spinal column injury 17.91 12.00 25 370620 622 42250068
Retinal injury 17.91 12.00 12 370633 113 42250577
Long QT syndrome 17.89 12.00 3 370642 3164 42247526
Hypocalcaemia 17.88 12.00 365 370280 29808 42220882
Joint effusion 17.84 12.00 15 370630 5882 42244808
Photosensitivity reaction 17.82 12.00 54 370591 12648 42238042
Klebsiella bacteraemia 17.75 12.00 53 370592 2311 42248379
Device related thrombosis 17.74 12.00 39 370606 1406 42249284
Ventricular septal defect 17.74 12.00 8 370637 4391 42246299
Myoglobin blood increased 17.74 12.00 5 370640 3677 42247013
Respirovirus test positive 17.71 12.00 10 370635 67 42250623
Venous thrombosis limb 17.68 12.00 53 370592 2316 42248374
Enthesopathy 17.64 12.00 10 370635 4818 42245872
Malignant transformation 17.60 12.00 31 370614 947 42249743
Corneal abscess 17.52 12.00 7 370638 18 42250672
Retinal vein thrombosis 17.51 12.00 20 370625 404 42250286
Cavernous sinus thrombosis 17.50 12.00 14 370631 177 42250513
Disinhibition 17.49 12.00 6 370639 3889 42246801
Cerebral venous thrombosis 17.46 12.00 32 370613 1009 42249681
Hepatitis B 17.46 12.00 109 370536 6602 42244088
Lymphocyte count decreased 17.34 12.00 339 370306 27470 42223220
Gout 17.34 12.00 158 370487 27897 42222793
Septic embolus 17.34 12.00 38 370607 1367 42249323
Psychomotor skills impaired 17.33 12.00 12 370633 5192 42245498
Blood immunoglobulin E increased 17.32 12.00 5 370640 3620 42247070
Posterior capsule rupture 17.26 12.00 7 370638 19 42250671
Hepatitis viral 17.20 12.00 28 370617 801 42249889
Encephalitis enteroviral 17.19 12.00 14 370631 182 42250508
Nasal polyps 17.17 12.00 6 370639 3845 42246845
Plantar fasciitis 17.14 12.00 3 370642 3067 42247623
Altered state of consciousness 17.13 12.00 167 370478 29092 42221598
Drug level below therapeutic 17.07 12.00 19 370626 6526 42244164
Inflammation 17.07 12.00 200 370445 33647 42217043
Lymphodepletion 17.06 12.00 8 370637 34 42250656
Blood culture positive 17.06 12.00 88 370557 4965 42245725
Lymphocytic leukaemia 17.06 12.00 15 370630 218 42250472
Central nervous system leukaemia 17.01 12.00 19 370626 374 42250316
Plasmacytosis 17.01 12.00 10 370635 73 42250617
Secretion discharge 16.98 12.00 25 370620 7610 42243080
Allergy test negative 16.95 12.00 13 370632 154 42250536
Epstein-Barr virus associated lymphoma 16.92 12.00 32 370613 1034 42249656
Device related infection 16.91 12.00 259 370386 20020 42230670
Chorioretinitis 16.90 12.00 24 370621 607 42250083
Persecutory delusion 16.87 12.00 5 370640 3559 42247131
Vena cava thrombosis 16.80 12.00 40 370605 1521 42249169
Musculoskeletal chest pain 16.80 12.00 160 370485 11044 42239646
Upper respiratory tract infection 16.76 12.00 483 370162 41690 42209000
Sternal fracture 16.71 12.00 28 370617 821 42249869
Eosinophil percentage decreased 16.70 12.00 16 370629 261 42250429
Inflammatory bowel disease 16.62 12.00 5 370640 3524 42247166
Interleukin level increased 16.58 12.00 29 370616 881 42249809
Chromaturia 16.54 12.00 77 370568 15912 42234778
Angina unstable 16.54 12.00 48 370597 11400 42239290
Fungal oesophagitis 16.54 12.00 20 370625 430 42250260
Colitis 16.52 12.00 526 370119 46046 42204644
Autism spectrum disorder 16.51 12.00 3 370642 2985 42247705
Influenza like illness 16.50 12.00 187 370458 31653 42219037
Blood immunoglobulin D increased 16.44 12.00 5 370640 3 42250687
Tearfulness 16.41 12.00 5 370640 3495 42247195
Pneumonia acinetobacter 16.41 12.00 15 370630 230 42250460
Depression suicidal 16.41 12.00 4 370641 3241 42247449
Critical illness 16.30 12.00 15 370630 232 42250458
Treatment failure 16.30 12.00 417 370228 62207 42188483
Anaphylactic reaction 16.29 12.00 487 370158 42256 42208434
Irritability 16.28 12.00 161 370484 27967 42222723
Pneumococcal infection 16.23 12.00 22 370623 532 42250158
Exostosis 16.22 12.00 15 370630 5616 42245074
Meibomian gland dysfunction 16.20 12.00 11 370634 106 42250584
Brain oedema 16.20 12.00 215 370430 16112 42234578
Jaw disorder 16.19 12.00 48 370597 2085 42248605
Hepatocellular carcinoma 16.19 12.00 29 370616 8165 42242525
Idiopathic pulmonary fibrosis 16.17 12.00 10 370635 4594 42246096
Glaucoma 16.16 12.00 125 370520 8123 42242567
Gingivitis 16.16 12.00 73 370572 3900 42246790
Cell-mediated immune deficiency 16.16 12.00 10 370635 81 42250609
Musculoskeletal pain 16.05 12.00 199 370446 33141 42217549
Tear break up time decreased 16.03 12.00 6 370639 12 42250678
Sleep terror 16.03 12.00 3 370642 2923 42247767
Withdrawal syndrome 15.98 12.00 70 370575 14705 42235985
Refeeding syndrome 15.96 12.00 10 370635 83 42250607
Developmental delay 15.94 12.00 4 370641 3178 42247512
Glioblastoma multiforme 15.93 12.00 28 370617 854 42249836
Differentiation syndrome 15.91 12.00 43 370602 1770 42248920
Chalazion 15.83 12.00 13 370632 171 42250519
Somnambulism 15.79 12.00 5 370640 3410 42247280
Pneumonia staphylococcal 15.77 12.00 66 370579 3410 42247280
Vomiting 15.75 12.00 2244 368401 287479 41963211
Device occlusion 15.73 12.00 31 370614 8419 42242271
Lupus-like syndrome 15.73 12.00 4 370641 3150 42247540
Lumbar vertebral fracture 15.72 12.00 62 370583 3117 42247573
Full blood count abnormal 15.67 12.00 175 370470 29701 42220989
VIth nerve disorder 15.65 12.00 7 370638 26 42250664
Glomerular filtration rate decreased 15.62 12.00 81 370564 16270 42234420
Injection site urticaria 15.56 12.00 5 370640 3378 42247312
Pulmonary congestion 15.55 12.00 77 370568 15653 42235037
Neuralgic amyotrophy 15.54 12.00 16 370629 286 42250404
Therapeutic response unexpected 15.53 12.00 49 370596 11332 42239358
Mental impairment 15.46 12.00 55 370590 12262 42238428
Congenital herpes simplex infection 15.45 12.00 7 370638 27 42250663
Immunoglobulins decreased 15.45 12.00 30 370615 989 42249701
POEMS syndrome 15.44 12.00 8 370637 44 42250646
Bronchitis 15.44 12.00 528 370117 46673 42204017
Bacterial endophthalmitis 15.39 12.00 11 370634 116 42250574
Testicular germ cell cancer metastatic 15.39 12.00 9 370636 65 42250625
Blood thyroid stimulating hormone increased 15.36 12.00 14 370631 5278 42245412
Pneumonia legionella 15.32 12.00 49 370596 2219 42248471
Post-acute COVID-19 syndrome 15.31 12.00 19 370626 420 42250270
Confusional state 15.27 12.00 1252 369393 166345 42084345
Nocardiosis 15.23 12.00 87 370558 5103 42245587
Phrenic nerve paralysis 15.23 12.00 13 370632 181 42250509
Presyncope 15.21 12.00 123 370522 22264 42228426
SARS-CoV-2 viraemia 15.20 12.00 10 370635 91 42250599
Dysuria 15.20 12.00 185 370460 30911 42219779
Keratitis bacterial 15.16 12.00 11 370634 119 42250571
Amnesia 15.14 12.00 166 370479 28271 42222419
Fungal sepsis 15.13 12.00 31 370614 1063 42249627
Lower gastrointestinal haemorrhage 15.12 12.00 46 370599 10762 42239928
Hordeolum 15.08 12.00 39 370606 1563 42249127
Cholelithiasis 15.08 12.00 130 370515 23216 42227474
Left ventricular hypertrophy 15.03 12.00 37 370608 9282 42241408
Iris bombe 15.01 12.00 4 370641 0 42250690
VIIIth nerve lesion 15.01 12.00 4 370641 0 42250690
Periorbital infection 14.95 12.00 13 370632 186 42250504
Orthopnoea 14.94 12.00 15 370630 5402 42245288
Cataract cortical 14.93 12.00 11 370634 122 42250568
Upper gastrointestinal haemorrhage 14.91 12.00 180 370465 30119 42220571
Nerve injury 14.90 12.00 71 370574 3879 42246811
Polyp 14.89 12.00 11 370634 4603 42246087
Oropharyngeal candidiasis 14.88 12.00 28 370617 901 42249789
Bundle branch block right 14.87 12.00 30 370615 8076 42242614
Vertebral column mass 14.85 12.00 10 370635 95 42250595
Post procedural hypotension 14.84 12.00 9 370636 70 42250620
Haematopoietic stem cell mobilisation 14.82 12.00 17 370628 345 42250345
Corneal thinning 14.79 12.00 12 370633 155 42250535
Aspiration bone marrow abnormal 14.79 12.00 11 370634 124 42250566
Eye pain 14.78 12.00 219 370426 16811 42233879
Peripheral swelling 14.78 12.00 942 369703 89328 42161362
Infectious pleural effusion 14.76 12.00 61 370584 3134 42247556
Pain of skin 14.74 12.00 30 370615 8050 42242640
Pneumonia cytomegaloviral 14.73 12.00 73 370572 4053 42246637
Mood altered 14.73 12.00 46 370599 10672 42240018
Corneal disorder 14.64 12.00 30 370615 1029 42249661
White blood cell count increased 14.64 12.00 290 370355 44797 42205893
Diverticulum 14.62 12.00 27 370618 7514 42243176
Adenoviral hepatitis 14.59 12.00 21 370624 538 42250152
Low density lipoprotein increased 14.58 12.00 15 370630 5340 42245350
Therapy cessation 14.53 12.00 111 370534 20339 42230351
Lactose intolerance 14.52 12.00 37 370608 1469 42249221
Dysarthria 14.49 12.00 251 370394 39556 42211134
Respiratory distress 14.49 12.00 471 370174 41349 42209341
Defaecation urgency 14.46 12.00 7 370638 3687 42247003
Orbital compartment syndrome 14.45 12.00 5 370640 7 42250683
Maternal exposure during pregnancy 14.42 12.00 24 370621 6954 42243736
Sarcoidosis 14.38 12.00 7 370638 3675 42247015
Electrocardiogram Q waves 14.36 12.00 7 370638 33 42250657
Peripheral vascular disorder 14.35 12.00 15 370630 5302 42245388
Disseminated coccidioidomycosis 14.35 12.00 10 370635 101 42250589
High density lipoprotein decreased 14.34 12.00 8 370637 3889 42246801
Gastritis 14.31 12.00 136 370509 23811 42226879
Varicella 14.30 12.00 45 370600 2020 42248670
Corneal epithelium defect 14.29 12.00 18 370627 404 42250286
Amoebic colitis 14.26 12.00 10 370635 102 42250588
Exposed bone in jaw 14.26 12.00 38 370607 1551 42249139
Impaired driving ability 14.26 12.00 4 370641 2951 42247739
Drooling 14.20 12.00 10 370635 4289 42246401
Jugular vein thrombosis 14.18 12.00 45 370600 2029 42248661
Injection site warmth 14.18 12.00 3 370642 2680 42248010
Hypercalcaemia of malignancy 14.17 12.00 16 370629 319 42250371
Chest discomfort 14.15 12.00 433 370212 63183 42187507
Blood stem cell harvest 14.12 12.00 6 370639 19 42250671
Myeloma cast nephropathy 14.10 12.00 10 370635 104 42250586
Tension headache 14.10 12.00 6 370639 3408 42247282
Stress echocardiogram abnormal 14.06 12.00 5 370640 8 42250682
Bradyphrenia 14.03 12.00 15 370630 5247 42245443
Herpes simplex encephalitis 14.01 12.00 17 370628 367 42250323
Gastric ulcer 14.00 12.00 97 370548 18165 42232525
Schizophrenia 13.99 12.00 46 370599 10504 42240186
Spinal pain 13.97 12.00 104 370541 6678 42244012
Speech disorder 13.95 12.00 174 370471 28947 42221743
Superior sagittal sinus thrombosis 13.86 12.00 16 370629 327 42250363
Tooth deposit 13.86 12.00 9 370636 80 42250610
Metastases to meninges 13.82 12.00 43 370602 1918 42248772
Ulcer 13.78 12.00 85 370560 16356 42234334
Colitis microscopic 13.77 12.00 5 370640 3128 42247562
Intestinal atresia 13.76 12.00 9 370636 81 42250609
Oesophageal carcinoma 13.76 12.00 41 370604 9655 42241035
Prostate cancer stage I 13.71 12.00 3 370642 2618 42248072
Diffuse large B-cell lymphoma 13.68 12.00 134 370511 9320 42241370
Plasma cells decreased 13.65 12.00 8 370637 58 42250632
Lentigo maligna 13.62 12.00 17 370628 378 42250312
Pericardial haemorrhage 13.61 12.00 7 370638 3562 42247128
Rales 13.59 12.00 52 370593 11348 42239342
Atypical pneumonia 13.59 12.00 71 370574 4026 42246664
Malignant glioma 13.58 12.00 7 370638 38 42250652
Corneal degeneration 13.58 12.00 7 370638 38 42250652
B-cell lymphoma refractory 13.58 12.00 13 370632 212 42250478
Bone erosion 13.57 12.00 11 370634 4392 42246298
Renal disorder 13.54 12.00 339 370306 28641 42222049
VIth nerve paralysis 13.54 12.00 27 370618 908 42249782
Euphoric mood 13.52 12.00 22 370623 6431 42244259
Hepatitis 13.50 12.00 162 370483 27138 42223552
Malignant melanoma 13.49 12.00 133 370512 9267 42241423
Asphyxia 13.48 12.00 33 370612 8293 42242397
Thyrotoxic periodic paralysis 13.45 12.00 12 370633 178 42250512
Dialysis 13.45 12.00 56 370589 11930 42238760
Haemodialysis 13.42 12.00 45 370600 10215 42240475
Restless legs syndrome 13.39 12.00 41 370604 9573 42241117
Rash pruritic 13.39 12.00 385 370260 33218 42217472
Subdural hygroma 13.32 12.00 18 370627 434 42250256
Priapism 13.28 12.00 22 370623 6385 42244305
Panophthalmitis 13.27 12.00 6 370639 23 42250667
Eye irritation 13.25 12.00 52 370593 11266 42239424
Hyphaema 13.19 12.00 23 370622 697 42249993
Focal segmental glomerulosclerosis 13.16 12.00 3 370642 2545 42248145
Pneumonia mycoplasmal 13.11 12.00 24 370621 756 42249934
Metastases to spleen 13.11 12.00 19 370626 490 42250200
Eastern Cooperative Oncology Group performance status worsened 13.07 12.00 33 370612 1303 42249387
Personality change due to a general medical condition 13.02 12.00 7 370638 42 42250648
Coordination abnormal 12.96 12.00 32 370613 8018 42242672
Scratch 12.94 12.00 16 370629 5245 42245445
Diabetic metabolic decompensation 12.93 12.00 44 370601 2058 42248632
Tumour flare 12.91 12.00 30 370615 1123 42249567
Confusion postoperative 12.90 12.00 11 370634 153 42250537
Intervertebral disc degeneration 12.89 12.00 28 370617 7339 42243351
Myocarditis 12.89 12.00 104 370541 18834 42231856
Campylobacter colitis 12.89 12.00 7 370638 43 42250647
Neutrophil count abnormal 12.87 12.00 53 370592 2718 42247972
Hepatotoxicity 12.85 12.00 298 370347 24869 42225821
Post procedural infection 12.81 12.00 19 370626 5766 42244924
Fascial infection 12.80 12.00 4 370641 3 42250687
Rhinitis 12.80 12.00 57 370588 11920 42238770
Renal injury 12.79 12.00 59 370586 12221 42238469
Acidosis 12.78 12.00 59 370586 12220 42238470
Renal tubular acidosis 12.76 12.00 4 370641 2746 42247944
Basosquamous carcinoma of skin 12.75 12.00 5 370640 12 42250678
Capillary leak syndrome 12.75 12.00 52 370593 2655 42248035
Enterovirus infection 12.71 12.00 32 370613 1261 42249429
Device failure 12.71 12.00 4 370641 2739 42247951
Burning sensation 12.70 12.00 119 370526 20894 42229796
Major depression 12.68 12.00 17 370628 5381 42245309
Hepatic cancer 12.66 12.00 35 370610 8445 42242245
Hypogeusia 12.64 12.00 29 370616 1076 42249614
Back disorder 12.64 12.00 110 370535 7404 42243286
Bone sequestrum 12.60 12.00 19 370626 508 42250182
Subarachnoid haemorrhage 12.56 12.00 74 370571 14398 42236292
Eschar 12.53 12.00 23 370622 726 42249964
Transitional cell cancer of the renal pelvis and ureter 12.53 12.00 6 370639 27 42250663
Initial insomnia 12.51 12.00 10 370635 4020 42246670
Hypoxia 12.49 12.00 734 369911 69052 42181638
Hot flush 12.49 12.00 129 370516 22222 42228468
Pneumonia klebsiella 12.48 12.00 71 370574 4158 42246532
Oesophageal adenocarcinoma 12.47 12.00 27 370618 963 42249727
Hyperreflexia 12.44 12.00 8 370637 3599 42247091
Haematocrit decreased 12.42 12.00 221 370424 34687 42216003
Unresponsive to stimuli 12.42 12.00 195 370450 31208 42219482
Cryptococcal meningoencephalitis 12.42 12.00 12 370633 198 42250492
Dyspnoea 12.39 12.00 3546 367099 439075 41811615
Vernal keratoconjunctivitis 12.38 12.00 7 370638 47 42250643
HCoV-OC43 infection 12.38 12.00 7 370638 47 42250643
Amyotrophy 12.37 12.00 18 370627 466 42250224
Hyperbilirubinaemia 12.35 12.00 250 370395 20385 42230305
Macular fibrosis 12.34 12.00 16 370629 370 42250320
Gingival hypertrophy 12.34 12.00 3 370642 2436 42248254
Meningoencephalitis bacterial 12.33 12.00 11 370634 163 42250527
Central nervous system lymphoma 12.31 12.00 33 370612 1352 42249338
Varicella zoster virus infection 12.28 12.00 50 370595 2551 42248139
Plasma cells present 12.28 12.00 4 370641 4 42250686
Renal oncocytoma 12.27 12.00 12 370633 201 42250489
Palmar-plantar erythrodysaesthesia syndrome 12.25 12.00 117 370528 20465 42230225
Hyperaemia 12.21 12.00 35 370610 1491 42249199
SARS-CoV-2 sepsis 12.21 12.00 13 370632 242 42250448
Alanine aminotransferase abnormal 12.20 12.00 15 370630 4929 42245761
Radiation injury 12.20 12.00 19 370626 523 42250167
Abscess fungal 12.18 12.00 15 370630 329 42250361
Fat tissue increased 12.15 12.00 19 370626 525 42250165
Bladder sphincter atony 12.15 12.00 7 370638 49 42250641
Rash erythematous 12.12 12.00 201 370444 31890 42218800
Metastases to spine 12.12 12.00 56 370589 3021 42247669
Bronchopneumopathy 12.12 12.00 20 370625 579 42250111
Interstitial lung disease 12.11 12.00 558 370087 77904 42172786
Paraesthesia 12.10 12.00 767 369878 72692 42177998
Arachnoiditis 12.08 12.00 16 370629 378 42250312
Rib fracture 12.08 12.00 207 370438 16364 42234326
Feeling abnormal 12.07 12.00 490 370155 69296 42181394
Squamous cell carcinoma of head and neck 12.04 12.00 12 370633 206 42250484
Endocarditis histoplasma 12.03 12.00 6 370639 30 42250660
Cardiotoxicity 12.01 12.00 108 370537 7337 42243353

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 4586.72 10.15 3443 652540 59493 109873823
Neutropenia 4267.95 10.15 7822 648161 366798 109566518
Febrile neutropenia 3915.07 10.15 6855 649128 309912 109623404
Thrombocytopenia 3384.46 10.15 6807 649176 342078 109591238
Neuropathy peripheral 3107.64 10.15 4530 651453 174747 109758569
Disease progression 2071.17 10.15 4511 651472 239523 109693793
Off label use 1827.29 10.15 15126 640857 1485059 108448257
Pneumonia 1733.55 10.15 9965 646018 866749 109066567
Plasma cell myeloma recurrent 1489.91 10.15 761 655222 6281 109927035
Pancytopenia 1244.04 10.15 3377 652606 206236 109727080
Platelet count decreased 1239.43 10.15 3582 652401 226861 109706455
Completed suicide 1221.26 10.15 50 655933 242331 109690985
Sepsis 1092.75 10.15 4335 651648 323011 109610305
Cytokine release syndrome 997.86 10.15 1621 654362 68685 109864631
Arthralgia 937.45 10.15 2019 653964 777613 109155703
Cytopenia 906.72 10.15 1003 654980 29113 109904203
Death 880.14 10.15 7114 648869 691755 109241561
Septic shock 877.94 10.15 2481 653502 155047 109778269
Anaemia 867.91 10.15 5884 650099 541202 109392114
Deep vein thrombosis 856.98 10.15 2281 653702 137606 109795710
Rheumatoid arthritis 850.36 10.15 356 655627 299257 109634059
Polyneuropathy 848.40 10.15 998 654985 31014 109902302
Pain 845.75 10.15 2875 653108 952080 108981236
Neutrophil count decreased 803.39 10.15 2033 653950 118908 109814408
Drug hypersensitivity 753.73 10.15 952 655031 453138 109480178
Plasmacytoma 752.91 10.15 439 655544 4823 109928493
Joint swelling 742.78 10.15 921 655062 441924 109491392
Systemic lupus erythematosus 738.26 10.15 292 655691 254046 109679270
Mucosal inflammation 733.57 10.15 1705 654278 94436 109838880
Synovitis 728.84 10.15 357 655626 273735 109659581
White blood cell count decreased 725.92 10.15 2989 652994 226401 109706915
Tumour lysis syndrome 689.64 10.15 882 655101 29919 109903397
Neutropenic sepsis 681.45 10.15 876 655107 29870 109903446
Leukopenia 675.08 10.15 2180 653803 146611 109786705
Intentional overdose 661.71 10.15 29 655954 132472 109800844
Drug abuse 649.05 10.15 131 655852 177280 109756036
Therapy partial responder 638.80 10.15 935 655048 36126 109897190
Hand deformity 627.35 10.15 255 655728 218251 109715065
Contraindicated product administered 623.58 10.15 348 655635 247919 109685397
Pulmonary embolism 612.33 10.15 2709 653274 211765 109721551
Malignant neoplasm progression 607.82 10.15 2344 653639 172223 109761093
Pneumocystis jirovecii pneumonia 596.37 10.15 978 655005 41757 109891559
Pemphigus 588.00 10.15 268 655715 214302 109719014
Diarrhoea 574.85 10.15 9714 646269 1129791 108803525
Arthropathy 572.50 10.15 517 655466 287005 109646311
Pyrexia 569.18 10.15 7961 648022 890304 109043012
Injection site pain 562.94 10.15 177 655806 177745 109755571
Abdominal discomfort 552.97 10.15 928 655055 392930 109540386
Unevaluable event 547.80 10.15 1135 654848 58092 109875224
Therapeutic product effect decreased 546.83 10.15 391 655592 243925 109689391
Overdose 539.39 10.15 362 655621 233432 109699884
Swelling 528.87 10.15 789 655194 350252 109583064
Glossodynia 525.40 10.15 334 655649 221670 109711646
Musculoskeletal stiffness 495.56 10.15 557 655426 279265 109654051
Psoriatic arthropathy 495.22 10.15 275 655708 196486 109736830
Bronchopulmonary aspergillosis 483.97 10.15 732 655251 29131 109904185
COVID-19 pneumonia 482.21 10.15 823 655160 36320 109896996
Wound 469.69 10.15 419 655564 234018 109699298
Pericarditis 466.77 10.15 369 655614 218745 109714571
Constipation 458.69 10.15 3660 652323 354126 109579190
Anti-cyclic citrullinated peptide antibody positive 454.16 10.15 257 655726 181727 109751589
Psoriasis 452.34 10.15 134 655849 139859 109793457
Peripheral sensory neuropathy 448.57 10.15 524 655459 16156 109917160
Plasma cell myeloma refractory 440.08 10.15 222 655761 1779 109931537
Full blood count decreased 428.30 10.15 720 655263 31379 109901937
Helicobacter infection 416.28 10.15 284 655699 181593 109751723
Headache 413.81 10.15 3302 652681 879075 109054241
Haematotoxicity 413.78 10.15 566 655417 20516 109912800
Mucormycosis 413.33 10.15 406 655577 10222 109923094
Respiratory failure 408.59 10.15 2426 653557 212906 109720410
Myelodysplastic syndrome 407.80 10.15 769 655214 36715 109896601
Plasma cell leukaemia 394.01 10.15 209 655774 1879 109931437
Suicide attempt 389.44 10.15 71 655912 103323 109829993
Osteonecrosis 368.04 10.15 693 655290 33048 109900268
Multiple organ dysfunction syndrome 367.34 10.15 1827 654156 149883 109783433
Loss of personal independence in daily activities 361.38 10.15 221 655762 149799 109783517
Depression 360.57 10.15 846 655137 316489 109616827
Fibromyalgia 357.49 10.15 293 655690 170616 109762700
Posterior reversible encephalopathy syndrome 353.97 10.15 683 655300 33178 109900138
Asthma 349.88 10.15 591 655392 249700 109683616
Hepatic enzyme increased 348.42 10.15 876 655107 320016 109613300
Irritable bowel syndrome 346.62 10.15 279 655704 163936 109769380
Bone marrow failure 343.66 10.15 933 655050 56915 109876401
Drug interaction 339.62 10.15 1668 654315 498515 109434801
Endophthalmitis 337.64 10.15 323 655660 7864 109925452
Wheezing 335.71 10.15 626 655357 254604 109678712
Mobility decreased 332.43 10.15 560 655423 236862 109696454
Hyperglycaemia 328.04 10.15 1181 654802 83909 109849407
Arthritis 324.37 10.15 309 655674 167277 109766039
Impaired healing 323.27 10.15 415 655568 196302 109737014
Duodenal ulcer perforation 320.79 10.15 348 655635 177352 109755964
Drug ineffective for unapproved indication 319.44 10.15 1333 654650 101505 109831811
Folliculitis 318.84 10.15 314 655669 167339 109765977
Weight increased 316.65 10.15 1346 654637 418298 109515018
Haemophagocytic lymphohistiocytosis 312.22 10.15 622 655361 30937 109902379
Anaphylactic shock 307.84 10.15 833 655150 50713 109882603
Type 2 diabetes mellitus 306.93 10.15 359 655624 176873 109756443
COVID-19 305.70 10.15 2492 653491 242568 109690748
Muscle injury 303.76 10.15 234 655749 140573 109792743
Lymphopenia 301.47 10.15 708 655275 39462 109893854
Drug intolerance 299.29 10.15 1316 654667 405196 109528120
Osteoarthritis 298.29 10.15 387 655596 182236 109751080
Cytomegalovirus infection reactivation 296.52 10.15 449 655534 17884 109915432
Injury 295.39 10.15 370 655613 176895 109756421
Pain in extremity 295.21 10.15 1688 654295 485430 109447886
Stress 294.13 10.15 128 655855 105220 109828096
Immune effector cell-associated neurotoxicity syndrome 293.34 10.15 399 655584 14383 109918933
Sleep disorder 292.66 10.15 453 655530 198191 109735125
Neurotoxicity 288.99 10.15 718 655265 41489 109891827
Thrombosis 286.36 10.15 1341 654642 107321 109825995
Cytomegalovirus chorioretinitis 282.24 10.15 275 655708 6853 109926463
Migraine 282.16 10.15 362 655621 171290 109762026
Flushing 281.49 10.15 1300 654683 103436 109829880
Injection site erythema 276.60 10.15 106 655877 94070 109839246
Nasopharyngitis 272.26 10.15 1307 654676 393054 109540262
Strongyloidiasis 267.27 10.15 228 655755 4758 109928558
Light chain analysis increased 266.31 10.15 169 655814 2186 109931130
Blood cholesterol increased 265.95 10.15 428 655555 184357 109748959
Rhinocerebral mucormycosis 264.29 10.15 144 655839 1373 109931943
Diffuse large B-cell lymphoma recurrent 262.59 10.15 250 655733 6049 109927267
Myelosuppression 259.49 10.15 1179 654804 93161 109840155
Hypogammaglobulinaemia 258.15 10.15 443 655540 19633 109913683
Blister 255.93 10.15 609 655374 226767 109706549
Bacteraemia 255.10 10.15 687 655296 41703 109891613
Aspergillus infection 254.76 10.15 506 655477 25110 109908206
Sinusitis 252.88 10.15 906 655077 295782 109637534
Joint range of motion decreased 249.66 10.15 213 655770 121619 109811697
Injection site reaction 241.18 10.15 113 655870 88957 109844359
Condition aggravated 240.98 10.15 2996 652987 731840 109201476
Treatment failure 240.00 10.15 841 655142 276393 109656923
Osteolysis 239.41 10.15 224 655759 5299 109928017
Discomfort 239.32 10.15 578 655405 214129 109719187
Suicidal ideation 236.69 10.15 131 655852 93806 109839510
Cytomegalovirus infection 234.46 10.15 784 655199 53660 109879656
Colitis ulcerative 234.07 10.15 83 655900 77280 109856036
Rheumatoid factor positive 228.60 10.15 266 655717 131374 109801942
Facet joint syndrome 228.53 10.15 146 655837 96682 109836634
Hypercholesterolaemia 228.41 10.15 127 655856 90710 109842606
Febrile bone marrow aplasia 226.69 10.15 387 655596 17078 109916238
Gastrooesophageal reflux disease 226.52 10.15 453 655530 179523 109753793
Obesity 226.42 10.15 203 655780 113148 109820168
Acute lymphocytic leukaemia 225.62 10.15 221 655762 5544 109927772
Alopecia 220.29 10.15 1265 654718 363488 109569828
Intentional product misuse 219.74 10.15 279 655704 132625 109800691
Intraocular pressure increased 217.99 10.15 295 655688 10581 109922735
Inappropriate schedule of product administration 213.93 10.15 565 655418 203072 109730244
Acute lymphocytic leukaemia recurrent 213.82 10.15 215 655768 5572 109927744
Diffuse large B-cell lymphoma refractory 213.13 10.15 151 655832 2370 109930946
Pneumonitis 210.13 10.15 956 655027 75575 109857741
Bursitis 206.33 10.15 281 655702 129637 109803679
Ill-defined disorder 204.16 10.15 387 655596 156466 109776850
Bone pain 203.59 10.15 846 655137 64287 109869029
Sleep disorder due to general medical condition, insomnia type 200.67 10.15 198 655785 105445 109827871
Acute myeloid leukaemia 199.29 10.15 587 655396 37523 109895793
Inflammation 197.82 10.15 543 655440 192695 109740621
Rheumatic fever 192.78 10.15 267 655716 122312 109811004
Frequent bowel movements 189.57 10.15 93 655890 71297 109862019
Candida infection 188.98 10.15 671 655312 47338 109885978
Hypertriglyceridaemia 187.73 10.15 341 655642 15813 109917503
Injection site swelling 187.44 10.15 66 655917 61724 109871592
Maternal exposure during pregnancy 186.92 10.15 826 655157 254057 109679259
Atrial fibrillation 186.62 10.15 2134 653849 227508 109705808
Multiple sclerosis relapse 185.97 10.15 36 655947 50204 109883112
Parainfluenzae virus infection 184.05 10.15 217 655766 6757 109926559
B-cell type acute leukaemia 183.08 10.15 112 655871 1352 109931964
Clostridium difficile colitis 182.85 10.15 624 655359 43154 109890162
Squamous cell carcinoma of skin 181.02 10.15 348 655635 16855 109916461
Incorrect dose administered 180.40 10.15 209 655774 103432 109829884
Product quality issue 179.09 10.15 119 655864 77180 109856136
Breast cancer stage III 179.02 10.15 125 655858 78992 109854324
Urticaria 173.13 10.15 1143 654840 317714 109615602
Anxiety 171.66 10.15 1269 654714 343809 109589507
Blood pressure fluctuation 169.59 10.15 118 655865 74706 109858610
Musculoskeletal pain 169.45 10.15 539 655444 182484 109750832
Injection site pruritus 169.35 10.15 47 655936 51211 109882105
Neoplasm progression 169.28 10.15 796 655187 63799 109869517
Coeliac disease 168.46 10.15 27 655956 43160 109890156
Pruritus 167.96 10.15 2433 653550 579127 109354189
Wrong technique in product usage process 167.88 10.15 162 655821 87186 109846130
Dry mouth 166.73 10.15 616 655367 199332 109733984
Secondary immunodeficiency 165.97 10.15 170 655813 4506 109928810
Dehydration 165.55 10.15 2451 653532 277060 109656256
Sedation 164.53 10.15 105 655878 69578 109863738
Systemic candida 163.75 10.15 246 655737 9728 109923588
Rhabdomyolysis 162.96 10.15 290 655693 120111 109813205
Sleep disorder due to a general medical condition 162.70 10.15 53 655930 52059 109881257
Metastases to central nervous system 162.40 10.15 394 655589 22423 109910893
Product dose omission issue 160.68 10.15 1182 654801 320600 109612716
Renal failure 160.31 10.15 2051 653932 224523 109708793
Osteonecrosis of jaw 159.84 10.15 636 655347 47381 109885935
Hiccups 158.97 10.15 279 655704 12590 109920726
Intentional self-injury 158.83 10.15 18 655965 37411 109895905
C-reactive protein abnormal 157.62 10.15 333 655650 129362 109803954
Hypercalcaemia 156.12 10.15 619 655364 46038 109887278
Large intestine perforation 155.27 10.15 320 655663 16309 109917007
Injection site bruising 155.08 10.15 55 655928 51208 109882108
Disseminated aspergillosis 155.05 10.15 124 655859 2356 109930960
Pathological fracture 154.04 10.15 265 655718 11767 109921549
Therapy non-responder 150.20 10.15 1510 654473 155797 109777519
Therapeutic product effect incomplete 148.40 10.15 752 655231 223053 109710263
Blood pressure systolic increased 148.10 10.15 164 655819 82827 109850489
Ocular hypertension 145.46 10.15 118 655865 2290 109931026
Peripheral venous disease 144.92 10.15 171 655812 83946 109849370
Peripheral swelling 143.42 10.15 1618 654365 402416 109530900
Blood lactate dehydrogenase increased 143.40 10.15 582 655401 43752 109889564
Myelopathy 143.02 10.15 171 655812 5405 109927911
Escherichia bacteraemia 142.30 10.15 233 655750 9931 109923385
Malaise 141.81 10.15 2973 653010 668846 109264470
Fall 140.81 10.15 2626 653357 600856 109332460
Eczema 140.19 10.15 133 655850 72160 109861156
Hypofibrinogenaemia 139.22 10.15 117 655866 2390 109930926
Grip strength decreased 138.11 10.15 163 655820 80011 109853305
Hypoglycaemia 137.85 10.15 302 655681 115802 109817514
Blood pressure increased 137.81 10.15 931 655052 257442 109675874
Stem cell transplant 137.66 10.15 150 655833 4277 109929039
Memory impairment 136.76 10.15 651 655332 196293 109737023
Hepatitis B reactivation 136.52 10.15 194 655789 7290 109926026
Prescribed overdose 136.47 10.15 192 655791 87389 109845927
Accidental exposure to product 136.07 10.15 63 655920 49945 109883371
Venoocclusive liver disease 135.41 10.15 287 655696 14920 109918396
Rhinovirus infection 134.65 10.15 247 655736 11542 109921774
Acute respiratory distress syndrome 134.63 10.15 649 655334 52549 109880767
Lip dry 134.59 10.15 242 655741 99841 109833475
Pseudomonal sepsis 134.33 10.15 213 655770 8833 109924483
Hypoxia 133.81 10.15 1264 654719 128251 109805065
Listeriosis 133.41 10.15 120 655863 2694 109930622
Embolism 132.04 10.15 296 655687 15993 109917323
Disease recurrence 131.76 10.15 710 655273 60074 109873242
Foot deformity 130.48 10.15 62 655921 48418 109884898
Respiratory tract infection 129.40 10.15 797 655186 70820 109862496
Blepharospasm 129.02 10.15 83 655900 54768 109878548
Hypokalaemia 128.79 10.15 1651 654332 180797 109752519
Red blood cell sedimentation rate increased 128.77 10.15 165 655818 78137 109855179
Corneal oedema 128.61 10.15 124 655859 3049 109930267
Dizziness 127.23 10.15 3161 652822 695032 109238284
Gait disturbance 127.14 10.15 1047 654936 277161 109656155
Coma 126.84 10.15 323 655660 117546 109815770
Abortion spontaneous 125.97 10.15 25 655958 34257 109899059
Somnolence 125.89 10.15 1142 654841 296307 109637009
Liver injury 125.63 10.15 463 655520 149950 109783366
Pneumonia fungal 125.12 10.15 273 655710 14481 109918835
Neuroleptic malignant syndrome 122.74 10.15 26 655957 34033 109899283
Thymus hypoplasia 122.12 10.15 92 655891 1595 109931721
Substance-induced psychotic disorder 120.89 10.15 155 655828 5269 109928047
Nasal congestion 120.55 10.15 251 655732 98031 109835285
Finger deformity 119.80 10.15 25 655958 33067 109900249
Lymphoid tissue hypoplasia 118.75 10.15 90 655893 1575 109931741
Back injury 118.10 10.15 67 655916 47332 109885984
Disseminated strongyloidiasis 117.87 10.15 62 655921 547 109932769
Lactic acidosis 117.26 10.15 233 655750 92578 109840738
Joint stiffness 115.51 10.15 137 655846 67106 109866210
Fatigue 115.42 10.15 8533 647450 1207425 108725891
Spinal cord compression 115.16 10.15 180 655803 7372 109925944
Road traffic accident 114.26 10.15 296 655687 107102 109826214
Medication error 113.95 10.15 288 655695 105078 109828238
Pneumonia bacterial 113.79 10.15 379 655604 25882 109907434
Progressive multifocal leukoencephalopathy 113.37 10.15 366 655617 24590 109908726
Wound infection 112.81 10.15 253 655730 96212 109837104
Aplastic anaemia 112.71 10.15 359 655624 23949 109909367
Onychomycosis 112.09 10.15 44 655939 38487 109894829
Contusion 111.80 10.15 867 655116 232494 109700822
Febrile infection 111.78 10.15 135 655848 4313 109929003
Hospitalisation 111.69 10.15 450 655533 142043 109791273
Osteoporosis 111.66 10.15 217 655766 86935 109846381
Muscle spasticity 111.29 10.15 37 655946 35878 109897438
Hepatic cirrhosis 110.69 10.15 143 655840 67483 109865833
Pleural effusion 110.56 10.15 1572 654411 176137 109757179
Neutropenic colitis 110.37 10.15 183 655800 7882 109925434
Escherichia sepsis 109.56 10.15 209 655774 10063 109923253
Bone erosion 109.30 10.15 70 655913 46301 109887015
Staphylococcal bacteraemia 109.12 10.15 279 655704 16409 109916907
Bone lesion 108.18 10.15 169 655814 6918 109926398
Neck pain 108.17 10.15 371 655612 122759 109810557
Amyloidosis 108.13 10.15 113 655870 3068 109930248
Asthenia 106.83 10.15 5053 650930 683946 109249370
Pulmonary mucormycosis 106.79 10.15 94 655889 2049 109931267
Pneumonia influenzal 106.44 10.15 122 655861 3683 109929633
Disseminated intravascular coagulation 105.43 10.15 505 655478 40781 109892535
Pseudomonas infection 105.11 10.15 384 655599 27469 109905847
Bacterial sepsis 104.94 10.15 207 655776 10219 109923097
Surgery 104.82 10.15 57 655926 41226 109892090
Knee arthroplasty 104.60 10.15 139 655844 64809 109868507
Bronchospasm 104.26 10.15 405 655578 29834 109903482
Device issue 102.85 10.15 38 655945 34497 109898819
Peripheral motor neuropathy 102.66 10.15 124 655859 3962 109929354
Gastrointestinal disorder 102.32 10.15 929 655054 241023 109692293
Aplasia 101.58 10.15 174 655809 7699 109925617
Poisoning 101.30 10.15 24 655959 29081 109904235
Sopor 101.05 10.15 45 655938 36501 109896815
Palpitations 101.00 10.15 543 655440 158669 109774647
Accidental overdose 100.92 10.15 95 655888 51739 109881577
Obstructive airways disorder 100.38 10.15 76 655907 46073 109887243
Coronary artery disease 100.35 10.15 169 655814 71521 109861795
Therapeutic response shortened 99.85 10.15 26 655957 29557 109903759
Exostosis 99.56 10.15 76 655907 45880 109887436
Autonomic neuropathy 99.15 10.15 93 655890 2207 109931109
Monoclonal immunoglobulin present 98.71 10.15 97 655886 2443 109930873
Onychomadesis 98.30 10.15 76 655907 45587 109887729
Thrombotic microangiopathy 97.74 10.15 387 655596 28762 109904554
Visceral leishmaniasis 97.62 10.15 82 655901 1674 109931642
Cytomegalovirus viraemia 97.09 10.15 278 655705 17486 109915830
Blood pressure diastolic abnormal 96.61 10.15 18 655965 25797 109907519
Adrenal insufficiency 95.18 10.15 500 655483 41890 109891426
Choroiditis 95.15 10.15 78 655905 1537 109931779
Leukoencephalopathy 94.29 10.15 184 655799 9011 109924305
Human bocavirus infection 94.06 10.15 67 655916 1061 109932255
Injection site haemorrhage 93.98 10.15 39 655944 32989 109900327
Myalgia 93.97 10.15 854 655129 221527 109711789
Impaired work ability 93.52 10.15 21 655962 26398 109906918
Nail disorder 93.29 10.15 124 655859 57811 109875505
Cardiac amyloidosis 93.27 10.15 99 655884 2738 109930578
Drug withdrawal syndrome 93.09 10.15 55 655928 37999 109895317
Glioblastoma 92.80 10.15 85 655898 1955 109931361
B precursor type acute leukaemia 91.30 10.15 49 655934 452 109932864
Hyperviscosity syndrome 91.20 10.15 51 655932 514 109932802
Lupus-like syndrome 90.25 10.15 66 655917 40726 109892590
Swollen joint count increased 90.21 10.15 229 655754 83432 109849884
Injection site warmth 89.63 10.15 3 655980 17402 109915914
Premature delivery 89.61 10.15 390 655593 30242 109903074
Klebsiella infection 89.59 10.15 292 655691 19717 109913599
Anaphylactic reaction 89.58 10.15 1055 654928 113245 109820071
Brain oedema 89.50 10.15 394 655589 30704 109902612
Lung disorder 89.02 10.15 663 655320 179384 109753932
Sleep apnoea syndrome 88.76 10.15 66 655917 40381 109892935
Haematochezia 88.54 10.15 368 655615 115156 109818160
Heart rate decreased 88.09 10.15 228 655755 82528 109850788
Device difficult to use 88.02 10.15 6 655977 18799 109914517
Disseminated cryptococcosis 87.85 10.15 93 655890 2564 109930752
Red blood cell sedimentation rate abnormal 87.73 10.15 19 655964 24490 109908826
Blood pressure systolic abnormal 87.47 10.15 20 655963 24830 109908486
Night sweats 86.07 10.15 455 655528 133528 109799788
Product prescribing error 85.61 10.15 107 655876 51224 109882092
Pulmonary fibrosis 85.27 10.15 314 655669 101728 109831588
Dermatitis atopic 85.16 10.15 23 655960 25518 109907798
Pneumonia pneumococcal 85.16 10.15 125 655858 4840 109928476
Bacterial infection 84.85 10.15 515 655468 45521 109887795
Second primary malignancy 84.83 10.15 268 655715 17800 109915516
Primary amyloidosis 84.54 10.15 40 655943 274 109933042
Gait inability 83.82 10.15 470 655513 135906 109797410
Meningitis cryptococcal 83.29 10.15 121 655862 4641 109928675
Nervous system disorder 83.18 10.15 391 655592 31330 109901986
Respiratory distress 82.87 10.15 695 655288 68179 109865137
Cardiac murmur 82.45 10.15 22 655961 24606 109908710
Pneumatosis intestinalis 81.84 10.15 166 655817 8363 109924953
Meningitis listeria 81.41 10.15 65 655918 1232 109932084
Product label confusion 80.32 10.15 18 655965 22659 109910657
Blood creatine phosphokinase increased 79.59 10.15 199 655784 72878 109860438
Colitis 79.54 10.15 943 655040 101380 109831936
JC virus infection 79.16 10.15 125 655858 5165 109928151
International normalised ratio increased 78.57 10.15 258 655725 86514 109846802
Intestinal perforation 78.40 10.15 288 655695 20656 109912660
Hydrocephalus 77.98 10.15 183 655800 10192 109923124
C-reactive protein increased 77.90 10.15 871 655112 217048 109716268
Bone marrow disorder 77.81 10.15 110 655873 4113 109929203
Hypocalcaemia 77.80 10.15 658 655325 64708 109868608
Peripheral sensorimotor neuropathy 77.58 10.15 106 655877 3837 109929479
Diverticular perforation 77.38 10.15 137 655846 6225 109927091
Cryptococcosis 77.14 10.15 115 655868 4516 109928800
Blood pressure diastolic decreased 76.90 10.15 60 655923 35825 109897491
Underdose 76.52 10.15 164 655819 63390 109869926
Nightmare 75.93 10.15 71 655912 38792 109894524
Microsporidia infection 75.50 10.15 65 655918 1374 109931942
Ear infection 75.42 10.15 162 655821 62570 109870746
Pneumomediastinum 75.36 10.15 119 655864 4917 109928399
Enterococcal infection 75.36 10.15 279 655704 20087 109913229
Hypertension 75.20 10.15 2378 653605 507706 109425610
Eastern Cooperative Oncology Group performance status worsened 74.43 10.15 90 655893 2879 109930437
Hypertransaminasaemia 74.18 10.15 313 655670 23942 109909374
Visual acuity reduced 73.97 10.15 382 655601 31791 109901525
Chills 73.66 10.15 1562 654421 189018 109744298
Infection reactivation 73.28 10.15 105 655878 3976 109929340
Acute respiratory failure 73.04 10.15 725 655258 74535 109858781
Food allergy 72.35 10.15 15 655968 19933 109913383
Venous thrombosis 71.70 10.15 157 655826 8348 109924968
Corneal decompensation 71.70 10.15 25 655958 65 109933251
Adenocarcinoma of colon 71.41 10.15 130 655853 6038 109927278
Pulmonary sepsis 71.21 10.15 119 655864 5159 109928157
Hallucination 71.14 10.15 334 655649 101098 109832218
Staphylococcal sepsis 70.45 10.15 246 655737 17208 109916108
Ankylosing spondylitis 70.19 10.15 6 655977 15606 109917710
Herpes simplex encephalitis 70.02 10.15 50 655933 795 109932521
Enterocolitis 69.62 10.15 259 655724 18690 109914626
Neutropenic infection 69.62 10.15 91 655892 3154 109930162
Hypoalbuminaemia 69.40 10.15 348 655635 28626 109904690
Paraproteinaemia 69.22 10.15 42 655941 499 109932817
Abdominal pain upper 69.14 10.15 1560 654423 347551 109585765
Dysgeusia 68.80 10.15 676 655307 69309 109864007
Bronchiectasis 68.59 10.15 69 655914 36424 109896892
Serotonin syndrome 68.46 10.15 156 655827 58997 109874319
Labelled drug-drug interaction medication error 68.02 10.15 45 655938 29257 109904059
Ageusia 67.63 10.15 263 655720 19382 109913934
Guillain-Barre syndrome 67.54 10.15 177 655806 10567 109922749
Pneumonia parainfluenzae viral 67.52 10.15 45 655938 636 109932680
Escherichia infection 67.22 10.15 300 655683 23516 109909800
Drug dose omission by device 66.88 10.15 5 655978 14511 109918805
Enterobacter infection 66.68 10.15 122 655861 5689 109927627
Injection site urticaria 66.61 10.15 11 655972 17204 109916112
Malignant neoplasm of unknown primary site 66.53 10.15 47 655936 734 109932582
Herpes simplex reactivation 66.46 10.15 61 655922 1407 109931909
Enteritis 66.39 10.15 257 655726 18899 109914417
Rheumatoid nodule 66.32 10.15 19 655964 20277 109913039
Tenosynovitis 66.23 10.15 9 655974 16274 109917042
Dislocation of vertebra 65.99 10.15 98 655885 43623 109889693
Feeling abnormal 65.89 10.15 719 655264 179992 109753324
Haemoglobin decreased 65.57 10.15 1936 654047 246791 109686525
Infective pulmonary exacerbation of cystic fibrosis 65.54 10.15 6 655977 14765 109918551
Injection site mass 65.44 10.15 32 655951 24581 109908735
Device related infection 65.32 10.15 430 655553 39089 109894227
Dyspepsia 65.23 10.15 771 655212 190194 109743122
Myocardial infarction 65.05 10.15 777 655206 191306 109742010
Minimal residual disease 64.65 10.15 50 655933 903 109932413
Vasogenic cerebral oedema 64.18 10.15 73 655910 2185 109931131
Illness 64.06 10.15 260 655723 81911 109851405
Pneumothorax 63.93 10.15 393 655590 34892 109898424
Panic attack 63.79 10.15 47 655936 28893 109904423
Procedural pain 63.75 10.15 70 655913 35495 109897821
Mantle cell lymphoma recurrent 63.51 10.15 51 655932 975 109932341
Myasthenia gravis 63.51 10.15 24 655959 21487 109911829
Pneumonia viral 63.32 10.15 177 655806 10980 109922336
Cardiac failure 63.16 10.15 1508 654475 186118 109747198
Hip arthroplasty 63.13 10.15 149 655834 55664 109877652
Electrocardiogram QT prolonged 62.96 10.15 383 655600 108577 109824739
Alanine aminotransferase increased 62.76 10.15 1480 654503 182293 109751023
Device leakage 62.66 10.15 10 655973 16038 109917278
Glycosylated haemoglobin increased 62.35 10.15 31 655952 23588 109909728
Amnesia 62.24 10.15 368 655615 105040 109828276
Exposure via skin contact 62.11 10.15 4 655979 13143 109920173
Ileus 61.95 10.15 352 655631 30377 109902939
Laboratory test abnormal 61.93 10.15 461 655522 43618 109889698
Parkinsonism 61.85 10.15 27 655956 22160 109911156
Atrial flutter 61.39 10.15 296 655687 23966 109909350
Product use issue 61.37 10.15 1394 654589 310301 109623015
Crying 61.34 10.15 38 655945 25590 109907726
Pulmonary thrombosis 60.89 10.15 201 655782 13662 109919654
Decreased appetite 60.81 10.15 3427 652556 472419 109460897
Diffuse large B-cell lymphoma 60.68 10.15 220 655763 15678 109917638
Nocardiosis 60.64 10.15 136 655847 7350 109925966
Pneumonia cytomegaloviral 60.48 10.15 130 655853 6824 109926492
Exposure to toxic agent 60.48 10.15 4 655979 12854 109920462
Sciatica 60.34 10.15 312 655671 92087 109841229
Temperature regulation disorder 60.30 10.15 4 655979 12822 109920494
Refractory cytopenia with multilineage dysplasia 60.26 10.15 30 655953 233 109933083
Steroid diabetes 59.90 10.15 110 655873 5144 109928172
Confusional state 59.76 10.15 2225 653758 466455 109466861
Product storage error 59.69 10.15 27 655956 21701 109911615
Device malfunction 59.66 10.15 39 655944 25519 109907797
Chronic sinusitis 58.93 10.15 38 655945 25046 109908270
Cellulitis 58.88 10.15 1063 654920 124953 109808363
Cystitis bacterial 58.55 10.15 53 655930 1200 109932116
Acute kidney injury 58.44 10.15 4450 651533 630980 109302336
Atypical haemolytic uraemic syndrome 58.34 10.15 58 655925 1482 109931834
Pseudomyopia 58.21 10.15 26 655957 153 109933163
Cystitis haemorrhagic 58.15 10.15 182 655801 12027 109921289
Staphylococcal infection 58.11 10.15 653 655330 69291 109864025
Enterococcal bacteraemia 58.09 10.15 99 655884 4362 109928954
Rectal haemorrhage 57.93 10.15 444 655539 119389 109813927
Paraplegia 57.52 10.15 119 655864 6081 109927235
Respiratory syncytial virus infection 57.48 10.15 203 655780 14281 109919035
Norovirus test positive 57.47 10.15 47 655936 923 109932393
Streptococcal bacteraemia 57.38 10.15 101 655882 4568 109928748
Hepatotoxicity 57.34 10.15 602 655381 62798 109870518
Immunosuppression 57.32 10.15 233 655750 17526 109915790
Necrotising fasciitis 57.17 10.15 134 655849 7457 109925859
Lupus vulgaris 57.17 10.15 70 655913 33813 109899503
Hepatitis E 56.81 10.15 98 655885 4361 109928955
Exposure during pregnancy 56.78 10.15 677 655306 166747 109766569
Back pain 56.75 10.15 2718 653265 368278 109565038
Hyperaemia 56.24 10.15 89 655894 3684 109929632
Cushingoid 56.16 10.15 175 655808 11537 109921779
Gastrointestinal toxicity 55.71 10.15 169 655814 10979 109922337
Extrapyramidal disorder 54.92 10.15 54 655929 28813 109904503
Miosis 54.87 10.15 31 655952 21952 109911364
Macular degeneration 54.85 10.15 30 655953 21629 109911687
Female genital tract fistula 54.84 10.15 15 655968 16504 109916812
Disseminated mucormycosis 54.80 10.15 65 655918 2037 109931279
Brain abscess 54.80 10.15 123 655860 6651 109926665
Computerised tomogram thorax abnormal 54.78 10.15 75 655908 2720 109930596
Encephalitis 54.45 10.15 239 655744 18600 109914716
Clostridium difficile infection 54.44 10.15 510 655473 51619 109881697
Performance status decreased 54.44 10.15 128 655855 7138 109926178
Neutrophil count abnormal 54.22 10.15 104 655879 5028 109928288
Tendonitis 54.15 10.15 45 655938 26038 109907278
Multiple sclerosis 53.77 10.15 44 655939 25654 109907662
Influenza like illness 53.62 10.15 306 655677 88106 109845210
Carpal tunnel syndrome 53.46 10.15 34 655949 22576 109910740
Live birth 53.45 10.15 221 655762 69263 109864053
Epilepsy 53.42 10.15 361 655622 99848 109833468
Keratitis fungal 53.41 10.15 33 655950 406 109932910
Brain stem glioma 53.10 10.15 26 655957 194 109933122
Pseudomonal bacteraemia 53.00 10.15 94 655889 4277 109929039
Hyperbilirubinaemia 52.70 10.15 337 655646 30334 109902982
Human herpesvirus 6 infection 52.68 10.15 119 655864 6462 109926854
Eosinophilia 52.63 10.15 172 655811 57764 109875552
Respiratory arrest 52.33 10.15 174 655809 58125 109875191
Dyskinesia 52.29 10.15 145 655838 51301 109882015
Joint dislocation 52.22 10.15 76 655907 34114 109899202
Monoclonal immunoglobulin increased 52.05 10.15 37 655946 584 109932732
Tardive dyskinesia 51.83 10.15 9 655974 13570 109919746
Product complaint 51.73 10.15 10 655973 13962 109919354
Metapneumovirus infection 51.60 10.15 68 655915 2376 109930940
Chronic obstructive pulmonary disease 51.57 10.15 407 655576 108751 109824565
Blood culture positive 51.53 10.15 143 655840 8833 109924483
Enterocolitis infectious 51.01 10.15 81 655902 3363 109929953
Product dose omission in error 50.78 10.15 39 655944 23473 109909843
Impaired quality of life 50.66 10.15 62 655921 29955 109903361
Bone density decreased 50.63 10.15 16 655967 16026 109917290
Klebsiella bacteraemia 50.62 10.15 98 655885 4771 109928545
Adjustment disorder with depressed mood 50.56 10.15 116 655867 43767 109889549
Refractory anaemia with an excess of blasts 50.10 10.15 41 655942 806 109932510
Triple negative breast cancer 49.98 10.15 34 655949 498 109932818
Abdominal distension 49.90 10.15 734 655249 174369 109758947
Hiatus hernia 49.85 10.15 54 655929 27552 109905764
Fungaemia 49.78 10.15 111 655872 5975 109927341
Prescribed underdose 49.69 10.15 208 655775 64966 109868350
Pregnancy 49.65 10.15 147 655836 50920 109882396
Hyperkalaemia 49.61 10.15 540 655443 135256 109798060
Injection site induration 49.51 10.15 5 655978 11378 109921938
Pneumonia cryptococcal 49.51 10.15 68 655915 2474 109930842
Phrenic nerve paralysis 49.26 10.15 35 655948 552 109932764
Injection site rash 49.12 10.15 40 655943 23379 109909937
Akathisia 49.03 10.15 20 655963 17093 109916223
Keratopathy 48.88 10.15 50 655933 1323 109931993
Cardiotoxicity 48.67 10.15 214 655769 16667 109916649
Sinus congestion 48.22 10.15 66 655917 30393 109902923
Proctitis 48.14 10.15 20 655963 16907 109916409
Sedation complication 48.14 10.15 29 655954 19826 109913490
Gastrointestinal perforation 48.07 10.15 124 655859 7332 109925984
Neoplasm recurrence 48.05 10.15 100 655883 5132 109928184
Computerised tomogram thorax 47.96 10.15 33 655950 493 109932823
Transplant rejection 47.86 10.15 45 655938 24522 109908794
Poor venous access 47.67 10.15 45 655938 24477 109908839
Lymphocyte count decreased 47.36 10.15 534 655449 56709 109876607
Pulmonary arterial hypertension 47.23 10.15 75 655908 32493 109900823
Bone marrow infiltration 47.16 10.15 40 655943 828 109932488
Neoplasm 47.14 10.15 159 655824 10928 109922388
Fear 46.95 10.15 41 655942 23152 109910164
Cataract subcapsular 46.86 10.15 47 655936 1214 109932102
Oral candidiasis 46.79 10.15 438 655545 44322 109888994
Mycobacterium chelonae infection 46.75 10.15 73 655910 2987 109930329
Epistaxis 46.69 10.15 1057 654926 129315 109804001
Nodule 46.52 10.15 76 655907 32555 109900761
Sneezing 46.06 10.15 74 655909 31910 109901406
Necrotising retinitis 46.05 10.15 52 655931 1544 109931772
Joint effusion 46.02 10.15 34 655949 20871 109912445
Substance abuse 45.98 10.15 9 655974 12454 109920862
Therapy interrupted 45.89 10.15 147 655836 49675 109883641
Aggression 45.74 10.15 188 655795 59022 109874294
Nasal polyps 45.71 10.15 11 655972 13189 109920127
Rectal adenocarcinoma 45.31 10.15 53 655930 1636 109931680
Cerebral toxoplasmosis 45.31 10.15 73 655910 3069 109930247
Rhinitis allergic 45.13 10.15 25 655958 17897 109915419
Hypersensitivity 45.00 10.15 1948 654035 402050 109531266
Metastatic malignant melanoma 44.85 10.15 76 655907 3333 109929983
Ulcerative keratitis 44.83 10.15 92 655891 4674 109928642
Colitis microscopic 44.77 10.15 12 655971 13382 109919934
H1N1 influenza 44.73 10.15 71 655912 2947 109930369
Nephrolithiasis 44.70 10.15 221 655762 65991 109867325
Hypothalamic pituitary adrenal axis suppression 44.57 10.15 35 655948 647 109932669
Respiratory tract infection viral 44.53 10.15 104 655879 5774 109927542
Endocarditis 44.41 10.15 177 655806 13194 109920122
Non-small cell lung cancer 44.16 10.15 125 655858 7810 109925506
Depressed mood 43.96 10.15 198 655785 60611 109872705
Drug dependence 43.73 10.15 151 655832 49869 109883447
Product use in unapproved indication 43.60 10.15 3148 652835 444229 109489087
Fluid retention 43.45 10.15 354 655629 93953 109839363
Pemphigoid 43.44 10.15 32 655951 19675 109913641
Urosepsis 43.20 10.15 321 655662 30354 109902962
Product administration error 43.19 10.15 98 655885 37119 109896197
Viraemia 43.18 10.15 83 655900 4019 109929297
Candida pneumonia 42.73 10.15 41 655942 1002 109932314
Anhedonia 42.65 10.15 19 655964 15409 109917907
Drug level increased 42.43 10.15 143 655840 47576 109885740
Central nervous system leukaemia 42.27 10.15 32 655951 559 109932757
Breast cancer female 42.00 10.15 11 655972 12457 109920859
Iris atrophy 41.93 10.15 22 655961 193 109933123
Coombs indirect test positive 41.77 10.15 16 655967 59 109933257
Meningitis pneumococcal 41.73 10.15 35 655948 713 109932603
Hypopyon 41.69 10.15 47 655936 1393 109931923
Cholecystectomy 41.62 10.15 7 655976 10802 109922514
Disability 41.60 10.15 72 655911 30151 109903165
Differentiation syndrome 41.56 10.15 69 655914 2975 109930341
Maternal exposure timing unspecified 41.51 10.15 38 655945 20975 109912341
Cellulitis orbital 41.27 10.15 40 655943 990 109932326
Respiratory tract congestion 41.13 10.15 75 655908 30782 109902534
Platelet count abnormal 41.04 10.15 105 655878 6177 109927139
Ecthyma 40.98 10.15 40 655943 999 109932317
Iron deficiency anaemia 40.92 10.15 78 655905 31481 109901835
Arachnoiditis 40.81 10.15 40 655943 1004 109932312
Venous thrombosis limb 40.81 10.15 94 655889 5171 109928145
Eye pruritus 40.78 10.15 83 655900 32692 109900624
Hallucination, visual 40.72 10.15 111 655872 39494 109893822
Allergy test negative 40.43 10.15 27 655956 383 109932933
Blood immunoglobulin M decreased 40.36 10.15 55 655928 1986 109931330
Dry eye 40.14 10.15 182 655801 55611 109877705
Retinitis 40.11 10.15 82 655901 32245 109901071
Forced expiratory volume decreased 40.08 10.15 14 655969 13162 109920154
Cell-mediated immune deficiency 39.92 10.15 22 655961 215 109933101
Treatment noncompliance 39.88 10.15 261 655722 72729 109860587
Coombs positive haemolytic anaemia 39.85 10.15 48 655935 1529 109931787
Sinus disorder 39.77 10.15 84 655899 32644 109900672
Sensitivity to weather change 39.72 10.15 6 655977 10022 109923294
Product substitution issue 39.59 10.15 47 655936 23014 109910302
Microangiopathic haemolytic anaemia 39.39 10.15 53 655930 1890 109931426
Gastric perforation 39.31 10.15 89 655894 4840 109928476
Hypothyroidism 39.16 10.15 262 655721 72637 109860679
Atypical pneumonia 39.12 10.15 119 655864 7743 109925573
Schizophrenia 39.08 10.15 43 655940 21783 109911533
Lip swelling 39.06 10.15 161 655822 50506 109882810
Arterial occlusive disease 39.06 10.15 21 655962 15287 109918029
Chest pain 38.82 10.15 1830 654153 374545 109558771
Ejection fraction decreased 38.79 10.15 392 655591 40488 109892828
Cholelithiasis 38.73 10.15 219 655764 63203 109870113
Meningitis bacterial 38.70 10.15 68 655915 3071 109930245
Sternal fracture 38.53 10.15 70 655913 3246 109930070
Drug level decreased 38.51 10.15 32 655951 18516 109914800
Adverse reaction 38.50 10.15 73 655910 29521 109903795
Propofol infusion syndrome 38.50 10.15 61 655922 2528 109930788
Weight decreased 38.48 10.15 2328 653655 465729 109467587
Pneumonia respiratory syncytial viral 38.46 10.15 63 655920 2686 109930630
Enthesopathy 38.41 10.15 13 655970 12465 109920851
Hepatitis 38.38 10.15 345 655638 89709 109843607
Corneal disorder 38.36 10.15 61 655922 2536 109930780
Vaginal discharge 38.30 10.15 30 655953 17878 109915438
Insomnia 38.24 10.15 1748 654235 358842 109574474
Device adhesion issue 38.22 10.15 5 655978 9305 109924011
Respiratory depression 38.17 10.15 83 655900 31918 109901398
Muscle rigidity 38.11 10.15 52 655931 23979 109909337
Depressed level of consciousness 38.07 10.15 454 655529 111824 109821492
Laryngospasm 38.03 10.15 85 655898 4583 109928733
Central nervous system vasculitis 38.02 10.15 48 655935 1606 109931710
Hyperlipidaemia 37.97 10.15 99 655884 35749 109897567
Spinal compression fracture 37.95 10.15 212 655771 18180 109915136
Spinal fracture 37.85 10.15 247 655736 22386 109910930
Lower respiratory tract infection 37.81 10.15 1125 654858 241981 109691335
Tracheal deviation 37.78 10.15 23 655960 275 109933041
Electrocardiogram QRS complex prolonged 37.66 10.15 15 655968 13006 109920310
Peritonitis 37.62 10.15 326 655657 32281 109901035
Drug resistance 37.60 10.15 505 655478 55869 109877447
Encephalopathy 37.60 10.15 683 655300 80372 109852944
Pulmonary haemorrhage 37.56 10.15 195 655788 16261 109917055
Leukaemia recurrent 37.54 10.15 67 655916 3064 109930252
B-cell lymphoma recurrent 37.35 10.15 40 655943 1118 109932198
Bacterial endophthalmitis 37.33 10.15 24 655959 318 109932998
Eye irritation 37.28 10.15 90 655893 33362 109899954
Light chain analysis abnormal 37.27 10.15 21 655962 215 109933101
Polyp 37.26 10.15 7 655976 9973 109923343
Eosinophil count increased 37.14 10.15 42 655941 21016 109912300
Phaeochromocytoma crisis 37.14 10.15 28 655955 486 109932830
Vanishing bile duct syndrome 36.97 10.15 67 655916 3101 109930215
Neurological decompensation 36.92 10.15 107 655876 6776 109926540
Joint injury 36.84 10.15 118 655865 39876 109893440
Heavy menstrual bleeding 36.83 10.15 26 655957 16339 109916977
Stridor 36.81 10.15 107 655876 6788 109926528
Burning sensation 36.56 10.15 250 655733 68962 109864354
Steroid withdrawal syndrome 36.56 10.15 36 655947 909 109932407
Meningitis 36.56 10.15 152 655831 11550 109921766
Affect lability 36.46 10.15 34 655949 18603 109914713
Ulcer 36.46 10.15 132 655851 42984 109890332
Device breakage 36.45 10.15 18 655965 13751 109919565
Sexual dysfunction 36.45 10.15 4 655979 8526 109924790
Insurance issue 36.44 10.15 9 655974 10603 109922713
Laryngitis 36.42 10.15 129 655854 42282 109891034
Body temperature decreased 36.14 10.15 106 655877 36829 109896487
Product administration interrupted 36.11 10.15 11 655972 11281 109922035
Infection 36.02 10.15 2553 653430 359647 109573669
Lung infiltration 35.98 10.15 260 655723 24368 109908948
Porphyria acute 35.88 10.15 35 655948 18745 109914571
Alpha haemolytic streptococcal infection 35.76 10.15 71 655912 3522 109929794
Shock 35.72 10.15 480 655503 53108 109880208
Pneumonia escherichia 35.52 10.15 40 655943 1184 109932132
Negative pressure pulmonary oedema 35.51 10.15 31 655952 668 109932648
Pneumonia klebsiella 35.48 10.15 103 655880 6529 109926787
Hyperpyrexia 35.45 10.15 117 655866 7952 109925364
Fusarium infection 35.43 10.15 61 655922 2710 109930606
Seronegative arthritis 35.23 10.15 17 655966 13160 109920156
Protein total increased 35.15 10.15 83 655900 4641 109928675
Blood disorder 35.14 10.15 133 655850 9677 109923639
Tachypnoea 35.12 10.15 373 655610 39022 109894294
Tracheobronchitis 35.00 10.15 60 655923 2656 109930660
Cataract 34.87 10.15 664 655319 78821 109854495
Adverse event 34.62 10.15 446 655537 108363 109824953
Mitochondrial DNA mutation 34.55 10.15 26 655957 450 109932866
Human chorionic gonadotropin increased 34.49 10.15 44 655939 1488 109931828
Dissociation 34.48 10.15 8 655975 9834 109923482
Myeloma cast nephropathy 34.43 10.15 21 655962 252 109933064
Pseudomonas test positive 34.36 10.15 55 655928 2299 109931017
Hyperglycaemic hyperosmolar nonketotic syndrome 34.31 10.15 63 655920 2946 109930370
Platelet transfusion 34.25 10.15 61 655922 2785 109930531
Ureteric compression 34.18 10.15 22 655961 292 109933024
Cancer pain 34.16 10.15 103 655880 6669 109926647
Epstein-Barr virus infection 34.13 10.15 209 655774 18529 109914787
Adjustment disorder 33.66 10.15 11 655972 10784 109922532
Haemodynamic instability 33.65 10.15 242 655741 22646 109910670
Multiple drug therapy 33.64 10.15 4 655979 8010 109925306
Intentional dose omission 33.33 10.15 42 655941 20038 109913278
Drug-induced liver injury 33.27 10.15 506 655477 119561 109813755
Needle issue 33.22 10.15 34 655949 17806 109915510
Arteriosclerosis 33.19 10.15 60 655923 24707 109908609
Malignant transformation 33.08 10.15 43 655940 1482 109931834
Blood fibrinogen decreased 33.05 10.15 58 655925 2617 109930699
Renal impairment 33.01 10.15 1400 654583 187045 109746271
Basal cell carcinoma 32.91 10.15 412 655571 44858 109888458
Ovarian cyst 32.87 10.15 21 655962 13909 109919407
Ulcer haemorrhage 32.71 10.15 52 655931 22519 109910797
Hallucination, auditory 32.71 10.15 67 655916 26330 109906986
Salivary hypersecretion 32.67 10.15 33 655950 17388 109915928
Arteriosclerosis coronary artery 32.64 10.15 62 655921 25056 109908260
Jugular vein thrombosis 32.53 10.15 87 655896 5258 109928058
Acinetobacter infection 32.47 10.15 68 655915 3505 109929811
Deformity 32.31 10.15 10 655973 10150 109923166
Superior sagittal sinus thrombosis 32.31 10.15 37 655946 1116 109932200
Radiation skin injury 32.30 10.15 44 655939 1588 109931728
Varicella zoster virus infection 32.26 10.15 97 655886 6271 109927045
Gastrointestinal protozoal infection 32.17 10.15 15 655968 99 109933217
Blood stem cell harvest failure 32.17 10.15 16 655967 124 109933192
Pasteurella infection 32.13 10.15 17 655966 152 109933164
Burns second degree 32.11 10.15 4 655979 7729 109925587
Blood parathyroid hormone decreased 31.90 10.15 19 655964 13070 109920246
Vascular device infection 31.89 10.15 187 655796 16325 109916991
Full blood count abnormal 31.87 10.15 198 655785 55854 109877462
Escherichia urinary tract infection 31.84 10.15 184 655799 15978 109917338
Movement disorder 31.75 10.15 110 655873 36294 109897022
Chalazion 31.73 10.15 29 655954 665 109932651
Disturbance in attention 31.73 10.15 226 655757 61769 109871547
Blood glucose decreased 31.56 10.15 81 655902 29407 109903909
Immunosuppressant drug level increased 31.54 10.15 15 655968 11709 109921607
Familial periodic paralysis 31.50 10.15 22 655961 337 109932979
Corneal opacity 31.49 10.15 38 655945 1213 109932103
Infusion site reaction 31.48 10.15 35 655948 17647 109915669
Micturition urgency 31.46 10.15 41 655942 19279 109914037
Pneumococcal sepsis 31.36 10.15 51 655932 2161 109931155
Clostridium bacteraemia 31.35 10.15 25 655958 473 109932843
Recall phenomenon 31.28 10.15 40 655943 1356 109931960
Tubulointerstitial nephritis 31.26 10.15 191 655792 54093 109879223
Platelet disorder 31.16 10.15 68 655915 3607 109929709
Spinal operation 31.15 10.15 13 655970 10959 109922357
Paradoxical drug reaction 31.05 10.15 128 655855 9689 109923627
Monocyte chemotactic protein-1 increased 31.01 10.15 22 655961 346 109932970
Alpha tumour necrosis factor increased 31.01 10.15 23 655960 389 109932927
Capillary leak syndrome 31 10.15 81 655902 4827 109928489
Human herpesvirus 6 encephalitis 31.00 10.15 35 655948 1039 109932277
Hepatitis B 30.93 10.15 126 655857 9486 109923830
Antipsychotic drug level increased 30.72 10.15 3 655980 7012 109926304
Philadelphia chromosome positive 30.64 10.15 32 655951 868 109932448
Tuberculoma of central nervous system 30.62 10.15 27 655956 590 109932726
Fibrinous bronchitis 30.53 10.15 16 655967 140 109933176
Crossmatch incompatible 30.41 10.15 11 655972 33 109933283
Intraocular pressure decreased 30.18 10.15 17 655966 174 109933142
Pustular psoriasis 30.11 10.15 22 655961 13583 109919733
Erysipelas 30.09 10.15 156 655827 13002 109920314
Soft tissue infection 29.95 10.15 82 655901 5025 109928291
Secretion discharge 29.95 10.15 46 655937 20198 109913118
Incorrect product administration duration 29.92 10.15 47 655936 20451 109912865
Foot operation 29.85 10.15 4 655979 7309 109926007
Product monitoring error 29.83 10.15 8 655975 8919 109924397
Uterine perforation 29.76 10.15 3 655980 6837 109926479
Aeromonas infection 29.69 10.15 25 655958 512 109932804
Hypoaesthesia 29.44 10.15 1543 654440 312680 109620636
Iron deficiency 29.28 10.15 40 655943 18436 109914880
Sickle cell anaemia with crisis 29.28 10.15 10 655973 9535 109923781
Fungal oesophagitis 29.28 10.15 35 655948 1106 109932210
Metabolic acidosis 29.15 10.15 416 655567 99328 109833988
Choroidal detachment 29.11 10.15 29 655954 743 109932573
Partial seizures 29.10 10.15 139 655844 11210 109922106
Abdominal sepsis 29.01 10.15 51 655932 2304 109931012
Sputum discoloured 28.97 10.15 78 655905 27867 109905449
Hypotension 28.83 10.15 3539 652444 520310 109413006
Right ventricular failure 28.79 10.15 70 655913 25884 109907432
Dysentery 28.72 10.15 38 655945 1333 109931983
Panniculitis 28.67 10.15 30 655953 15552 109917764
Bradyphrenia 28.62 10.15 17 655966 11711 109921605
Epstein-Barr virus associated lymphoma 28.58 10.15 42 655941 1628 109931688
Epstein-Barr virus infection reactivation 28.50 10.15 70 655913 4014 109929302
SARS-CoV-2 test positive 28.43 10.15 185 655798 16750 109916566
Light chain disease 28.42 10.15 19 655964 270 109933046
Spondylitis 28.28 10.15 16 655967 11322 109921994
X-ray abnormal 28.23 10.15 123 655860 37994 109895322
Blood immunoglobulin A decreased 28.11 10.15 49 655934 2199 109931117
Blood immunoglobulin G decreased 28.06 10.15 83 655900 5317 109927999
Musculoskeletal chest pain 28.04 10.15 278 655705 28569 109904747
Engraftment syndrome 28.01 10.15 45 655938 1887 109931429
Vitreous haemorrhage 27.92 10.15 75 655908 4545 109928771
Perineal necrosis 27.65 10.15 16 655967 173 109933143
Tuberculosis of central nervous system 27.65 10.15 24 655959 513 109932803
Rhinorrhoea 27.65 10.15 435 655548 102231 109831085
Meningitis herpes 27.60 10.15 19 655964 284 109933032
Skin striae 27.55 10.15 48 655935 2153 109931163
Myopathy 27.48 10.15 247 655736 24713 109908603
Oedema 27.35 10.15 994 654989 208982 109724334
Bronchopulmonary aspergillosis allergic 27.32 10.15 8 655975 8418 109924898
Emotional distress 27.31 10.15 155 655828 44692 109888624
Leukaemic infiltration extramedullary 27.28 10.15 20 655963 332 109932984
Pneumocystis jirovecii infection 27.16 10.15 72 655911 4328 109928988
Blood pressure inadequately controlled 27.15 10.15 6 655977 7627 109925689
Injection site discolouration 27.13 10.15 10 655973 9093 109924223
Blood stem cell transplant failure 27.12 10.15 27 655956 691 109932625
Systemic mycosis 27.12 10.15 66 655917 3763 109929553
Blood thyroid stimulating hormone increased 27.08 10.15 20 655963 12281 109921035
Sarcoidosis 26.99 10.15 21 655962 12558 109920758
Lower limb fracture 26.97 10.15 301 655682 75047 109858269
Oroantral fistula 26.93 10.15 21 655962 384 109932932
Vascular pain 26.90 10.15 34 655949 1139 109932177
Restless legs syndrome 26.86 10.15 67 655916 24559 109908757
Metastases to meninges 26.82 10.15 79 655904 5049 109928267
Acute monocytic leukaemia 26.80 10.15 25 655958 589 109932727
VIth nerve paralysis 26.78 10.15 42 655941 1725 109931591
Autoimmune lymphoproliferative syndrome 26.78 10.15 17 655966 220 109933096
Klebsiella sepsis 26.70 10.15 69 655914 4084 109929232
Viral haemorrhagic cystitis 26.70 10.15 61 655922 3338 109929978
Interleukin level increased 26.64 10.15 40 655943 1581 109931735
Thrombophlebitis 26.59 10.15 103 655880 7576 109925740
Pneumonia staphylococcal 26.47 10.15 88 655895 6003 109927313
Wrong patient received product 26.42 10.15 4 655979 6670 109926646
Angina pectoris 26.39 10.15 239 655744 62056 109871260
Erythema 26.38 10.15 2039 653944 289408 109643908
Tension headache 26.34 10.15 12 655971 9606 109923710
Actinomycosis 26.33 10.15 36 655947 1304 109932012
Unintentional medical device removal 26.27 10.15 10 655973 8913 109924403
Meningitis candida 26.26 10.15 17 655966 228 109933088
Blood immunoglobulin A increased 26.21 10.15 39 655944 1529 109931787
Coronary artery occlusion 26.17 10.15 33 655950 15739 109917577
Human polyomavirus infection 26.17 10.15 42 655941 1760 109931556
Acne 26.16 10.15 106 655877 33414 109899902
Knee operation 26.05 10.15 5 655978 7017 109926299
Hypotony of eye 26.03 10.15 22 655961 453 109932863
Renal amyloidosis 25.99 10.15 19 655964 314 109933002
Foot fracture 25.96 10.15 72 655911 25474 109907842
Syringe issue 25.91 10.15 12 655971 9513 109923803
Oxygen saturation decreased 25.88 10.15 1159 654824 155823 109777493
Pneumonia mycoplasmal 25.86 10.15 41 655942 1700 109931616
Hysterectomy 25.78 10.15 8 655975 8106 109925210
Meningoencephalitis herpetic 25.77 10.15 49 655934 2353 109930963
Herpes zoster 25.72 10.15 833 655150 107546 109825770
Listeria sepsis 25.71 10.15 28 655955 798 109932518
Rales 25.68 10.15 69 655914 24670 109908646
Pneumonia streptococcal 25.64 10.15 61 655922 3428 109929888
Drug tolerance decreased 25.54 10.15 81 655902 27459 109905857
Device use error 25.43 10.15 11 655972 9078 109924238
Salmonella sepsis 25.36 10.15 21 655962 420 109932896
Papilloedema 25.35 10.15 99 655884 7310 109926006
Drug level above therapeutic 25.31 10.15 19 655964 11569 109921747
Infectious pleural effusion 25.25 10.15 75 655908 4816 109928500
Acute generalised exanthematous pustulosis 25.20 10.15 217 655766 21447 109911869
Herpes simplex 25.13 10.15 170 655813 15594 109917722
Hepatitis viral 25.10 10.15 37 655946 1438 109931878
Nasal oedema 25.10 10.15 5 655978 6834 109926482
Encephalitis brain stem 25.05 10.15 19 655964 333 109932983
Cerebral venous thrombosis 25.02 10.15 58 655925 3204 109930112
Rotator cuff syndrome 25.00 10.15 38 655945 16756 109916560
Device failure 24.97 10.15 6 655977 7201 109926115
Drug use disorder 24.93 10.15 43 655940 18031 109915285
Cellulitis enterococcal 24.91 10.15 10 655973 43 109933273
Chorioretinopathy 24.85 10.15 47 655936 2248 109931068
Impaired driving ability 24.80 10.15 4 655979 6366 109926950
Blood loss anaemia 24.76 10.15 43 655940 17982 109915334
Pneumonia legionella 24.73 10.15 61 655922 3508 109929808
Withdrawal syndrome 24.64 10.15 99 655884 31281 109902035
Anger 24.62 10.15 47 655936 18960 109914356
Dystonia 24.57 10.15 75 655908 25730 109907586
Dysphonia 24.55 10.15 607 655376 75322 109857994
Oesophageal candidiasis 24.50 10.15 134 655849 11400 109921916
Gastric disorder 24.48 10.15 108 655875 33249 109900067
Skin haemorrhage 24.47 10.15 71 655912 24756 109908560
Failure to thrive 24.47 10.15 151 655832 13423 109919893
Enterococcal sepsis 24.44 10.15 58 655925 3254 109930062
Lymphodepletion 24.38 10.15 10 655973 46 109933270
Product dispensing error 24.31 10.15 37 655946 16308 109917008
Gangrene 24.30 10.15 37 655946 16304 109917012
Hyperamylasaemia 24.29 10.15 33 655950 1188 109932128
Antithrombin III deficiency 24.23 10.15 14 655969 151 109933165
Trichosporon infection 24.16 10.15 34 655949 1266 109932050
Mite allergy 24.10 10.15 3 655980 5800 109927516
Limb injury 24.05 10.15 128 655855 37508 109895808
Granuloma skin 24.01 10.15 19 655964 11264 109922052
Type I hypersensitivity 24.00 10.15 88 655895 6305 109927011
Oral pain 23.98 10.15 333 655650 37111 109896205
Bacillus infection 23.96 10.15 38 655945 1576 109931740
Blood pressure diastolic increased 23.93 10.15 47 655936 18760 109914556
Compression fracture 23.92 10.15 114 655869 9185 109924131
Lung adenocarcinoma 23.91 10.15 116 655867 9415 109923901
Taeniasis 23.88 10.15 10 655973 49 109933267
Catheterisation cardiac 23.86 10.15 4 655979 6187 109927129
Post-traumatic stress disorder 23.84 10.15 5 655978 6591 109926725
Pulmonary hypertension 23.77 10.15 211 655772 55009 109878307
Diffuse alveolar damage 23.75 10.15 65 655918 3982 109929334
Stress cardiomyopathy 23.75 10.15 168 655815 15638 109917678
Cauda equina syndrome 23.66 10.15 44 655939 2078 109931238
Vitreous loss 23.65 10.15 7 655976 8 109933308
Balamuthia infection 23.60 10.15 12 655971 98 109933218
Pre-existing condition improved 23.48 10.15 5 655978 6521 109926795
IVth nerve paralysis 23.46 10.15 24 655959 635 109932681
Pruritus genital 23.46 10.15 5 655978 6517 109926799
Acute erythroid leukaemia 23.45 10.15 19 655964 368 109932948
Lymphoma 23.44 10.15 202 655781 19969 109913347
Immunoglobulins decreased 23.39 10.15 47 655936 2352 109930964
Delusion 23.37 10.15 68 655915 23687 109909629
Diabetic metabolic decompensation 23.36 10.15 63 655920 3826 109929490
Salmonellosis 23.31 10.15 45 655938 2186 109931130
Kidney transplant rejection 23.30 10.15 22 655961 11965 109921351
Hypothermia 23.26 10.15 79 655904 26223 109907093
Heart rate increased 23.26 10.15 662 655321 143172 109790144
Carotid artery occlusion 23.15 10.15 14 655969 9551 109923765
Blindness 23.14 10.15 323 655660 36036 109897280
Acinetobacter bacteraemia 23.14 10.15 18 655965 328 109932988
Rib fracture 23.13 10.15 304 655679 33466 109899850
Embolism venous 23.12 10.15 74 655909 4949 109928367
Skin toxicity 23.11 10.15 134 655849 11649 109921667
Faeces discoloured 23.09 10.15 113 655870 33835 109899481
Bladder cancer 23.09 10.15 54 655929 20238 109913078
Erectile dysfunction 23.08 10.15 47 655936 18509 109914807
Abnormal dreams 23.08 10.15 25 655958 12755 109920561
Coronary artery bypass 23.07 10.15 4 655979 6038 109927278
Respiratory symptom 23.04 10.15 33 655950 14912 109918404
Splenic abscess 22.96 10.15 29 655954 971 109932345
Acute pulmonary oedema 22.89 10.15 176 655807 16820 109916496
Productive cough 22.81 10.15 510 655473 113795 109819521
Acute interstitial pneumonitis 22.80 10.15 35 655948 1411 109931905
Retinal ischaemia 22.79 10.15 29 655954 978 109932338
Lipogranuloma 22.78 10.15 7 655976 10 109933306
Campylobacter gastroenteritis 22.77 10.15 41 655942 1888 109931428
Varicella 22.73 10.15 61 655922 3694 109929622
Retinal vein thrombosis 22.72 10.15 25 655958 721 109932595
T-cell lymphoma refractory 22.71 10.15 12 655971 107 109933209
Autologous haematopoietic stem cell transplant 22.71 10.15 12 655971 107 109933209
Hyperferritinaemia 22.66 10.15 30 655953 1053 109932263
VIth nerve paresis 22.59 10.15 13 655970 139 109933177
Mental disorder 22.59 10.15 136 655847 38655 109894661
White blood cell count abnormal 22.58 10.15 91 655892 6818 109926498
Neoplasm skin 22.45 10.15 55 655928 3149 109930167
Blood phosphorus increased 22.42 10.15 39 655944 16301 109917015
Herpes simplex oesophagitis 22.42 10.15 20 655963 444 109932872
Head injury 22.41 10.15 156 655827 42861 109890455
Walking aid user 22.39 10.15 75 655908 25000 109908316
Congenital herpes simplex infection 22.39 10.15 7 655976 11 109933305
Chest wall mass 22.39 10.15 15 655968 214 109933102
Antithrombin III decreased 22.37 10.15 21 655962 499 109932817
Breast cancer stage II 22.37 10.15 85 655898 27290 109906026
Cardiac pacemaker insertion 22.32 10.15 5 655978 6296 109927020
Petechiae 22.32 10.15 224 655759 23093 109910223
Post procedural complication 22.28 10.15 82 655901 26576 109906740
Neuritis 22.27 10.15 8 655975 7391 109925925
Lineage switch leukaemia 22.23 10.15 10 655973 60 109933256
Vitamin D deficiency 22.22 10.15 48 655935 18504 109914812
Breast cancer stage I 22.21 10.15 8 655975 7379 109925937
Umbilical hernia 22.17 10.15 7 655976 7015 109926301
Coordination abnormal 22.16 10.15 76 655907 25152 109908164
Ileus paralytic 22.07 10.15 132 655851 11605 109921711
Bone debridement 22.01 10.15 19 655964 403 109932913
Glioblastoma multiforme 22.01 10.15 35 655948 1455 109931861
Bradykinesia 21.92 10.15 19 655964 10769 109922547
Pneumococcal infection 21.90 10.15 39 655944 1780 109931536
Cardiopulmonary failure 21.89 10.15 99 655884 7804 109925512
Implantation complication 21.88 10.15 8 655975 25 109933291
Pupillary deformity 21.88 10.15 8 655975 25 109933291
Palmoplantar keratoderma 21.86 10.15 3 655980 5384 109927932
Corneal thinning 21.85 10.15 16 655967 265 109933051
Angina unstable 21.85 10.15 40 655943 16392 109916924
Breast cancer metastatic 21.83 10.15 127 655856 11054 109922262
Melaena 21.81 10.15 282 655701 68475 109864841
Pulmonary infarction 21.76 10.15 64 655919 4087 109929229
Tachycardia 21.74 10.15 1593 654390 225052 109708264
Anaphylactoid shock 21.70 10.15 28 655955 958 109932358
Amenorrhoea 21.66 10.15 14 655969 9217 109924099
Wrong technique in device usage process 21.57 10.15 7 655976 6894 109926422
Haematoma 21.56 10.15 232 655751 58244 109875072
Intentional product use issue 21.55 10.15 1729 654254 246177 109687139
Periodontitis 21.54 10.15 74 655909 5134 109928182
Cytomegalovirus colitis 21.50 10.15 91 655892 6970 109926346
Intervertebral disc degeneration 21.49 10.15 47 655936 18038 109915278
Escherichia test positive 21.47 10.15 58 655925 3526 109929790
Cutaneous mucormycosis 21.43 10.15 24 655959 706 109932610
Respirovirus test positive 21.37 10.15 12 655971 122 109933194
Blood potassium decreased 21.37 10.15 445 655538 53669 109879647
Spinal fusion surgery 21.33 10.15 14 655969 9142 109924174
Colorectal adenocarcinoma 21.33 10.15 21 655962 530 109932786
Tear break up time decreased 21.33 10.15 7 655976 14 109933302
Lung transplant 21.32 10.15 3 655980 5283 109928033
Babesiosis 21.31 10.15 20 655963 475 109932841
Grip strength 21.27 10.15 14 655969 9127 109924189
Abscess bacterial 21.23 10.15 27 655956 910 109932406
Electrolyte imbalance 21.22 10.15 323 655660 36705 109896611
Plasmacytosis 21.18 10.15 14 655969 195 109933121
Pneumonia acinetobacter 21.12 10.15 18 655965 375 109932941
B-cell aplasia 21.08 10.15 18 655965 376 109932940
Panophthalmitis 21.00 10.15 14 655969 198 109933118
Retinal detachment 20.98 10.15 125 655858 10975 109922341
Hereditary angioedema 20.90 10.15 8 655975 7106 109926210
Psychotic disorder 20.90 10.15 197 655786 50740 109882576
Large intestinal ulcer perforation 20.84 10.15 10 655973 71 109933245
B-cell lymphoma refractory 20.83 10.15 13 655970 163 109933153
Large intestine polyp 20.82 10.15 36 655947 15081 109918235
Depressive symptom 20.81 10.15 12 655971 8402 109924914
Corneal perforation 20.81 10.15 27 655956 929 109932387
Alanine aminotransferase abnormal 20.78 10.15 15 655968 9319 109923997
Oxygen saturation 20.73 10.15 18 655965 385 109932931
Red blood cell count decreased 20.71 10.15 525 655458 65398 109867918
Madarosis 20.71 10.15 56 655927 3407 109929909
Palmar erythema 20.67 10.15 44 655939 2294 109931022
Dysaesthesia 20.66 10.15 88 655895 6759 109926557
Streptococcus test positive 20.63 10.15 47 655936 2567 109930749
Adenocarcinoma gastric 20.59 10.15 41 655942 2038 109931278
Urinary tract infection 20.58 10.15 2224 653759 324058 109609258
Cachexia 20.58 10.15 140 655843 12865 109920451
Beta 2 microglobulin increased 20.50 10.15 23 655960 678 109932638
Bradypnoea 20.46 10.15 13 655970 8636 109924680
Malignant syphilis 20.43 10.15 9 655974 51 109933265
Intracranial tumour haemorrhage 20.34 10.15 22 655961 622 109932694
Cholangitis infective 20.33 10.15 25 655958 814 109932502
Toxic neuropathy 20.32 10.15 29 655954 1094 109932222
Lymphocytic leukaemia 20.32 10.15 16 655967 297 109933019
Alopecia areata 20.32 10.15 42 655941 2145 109931171
Mucosal haemorrhage 20.27 10.15 51 655932 2969 109930347
Mucosal infection 20.21 10.15 20 655963 508 109932808
Gastroenteritis norovirus 20.21 10.15 57 655926 3554 109929762
Blood gases abnormal 20.20 10.15 32 655951 1326 109931990
Gastrointestinal fungal infection 20.16 10.15 24 655959 755 109932561
Corneal infiltrates 20.16 10.15 17 655966 349 109932967
Neuralgic amyotrophy 20.12 10.15 17 655966 350 109932966
Musculoskeletal disorder 20.09 10.15 68 655915 22596 109910720
Gene mutation 20.05 10.15 55 655928 3374 109929942
Heart rate irregular 20.04 10.15 120 655863 34154 109899162
Deep vein thrombosis postoperative 20.00 10.15 240 655743 59051 109874265
Cerebral aspergillosis 19.98 10.15 43 655940 2259 109931057
Superficial spreading melanoma stage unspecified 19.96 10.15 17 655966 354 109932962
Musculoskeletal discomfort 19.94 10.15 72 655911 23466 109909850
Iris adhesions 19.92 10.15 22 655961 637 109932679
SARS-CoV-2 viraemia 19.89 10.15 12 655971 141 109933175
Renal cancer 19.88 10.15 29 655954 13005 109920311
Inflammatory bowel disease 19.85 10.15 9 655974 7225 109926091
Superior vena cava occlusion 19.85 10.15 14 655969 218 109933098
Morganella infection 19.83 10.15 32 655951 1347 109931969
Immune-mediated myositis 19.83 10.15 6 655977 6180 109927136
Tumour pain 19.81 10.15 50 655933 2917 109930399
Spinal pain 19.76 10.15 182 655801 18333 109914983
Drug abuser 19.76 10.15 4 655979 5405 109927911
Mesenteric abscess 19.75 10.15 12 655971 143 109933173
Birdshot chorioretinopathy 19.73 10.15 10 655973 81 109933235
Abdominal pain 19.70 10.15 2704 653279 510285 109423031
Bone marrow necrosis 19.69 10.15 18 655965 413 109932903
Coronavirus infection 19.68 10.15 110 655873 9435 109923881
Vertebral lesion 19.62 10.15 22 655961 648 109932668
Haematopoietic stem cell mobilisation 19.62 10.15 18 655965 415 109932901
Ear canal erythema 19.61 10.15 9 655974 57 109933259
Carotid artery thrombosis 19.55 10.15 17 655966 9621 109923695
Social avoidant behaviour 19.55 10.15 4 655979 5365 109927951
General physical condition abnormal 19.49 10.15 93 655890 7497 109925819
Intercepted product preparation error 19.49 10.15 8 655975 6812 109926504
Blood immunoglobulin E increased 19.48 10.15 10 655973 7472 109925844
Fungal infection 19.48 10.15 416 655567 50390 109882926
Atrioventricular block first degree 19.48 10.15 34 655949 14191 109919125
Critical illness 19.44 10.15 20 655963 533 109932783
Meniscus injury 19.44 10.15 11 655972 7782 109925534
Atelectasis 19.43 10.15 316 655667 36396 109896920
Sense of oppression 19.42 10.15 35 655948 1613 109931703
Tumour flare 19.39 10.15 34 655949 1533 109931783
Keratitis bacterial 19.37 10.15 14 655969 227 109933089
Snoring 19.32 10.15 8 655975 6776 109926540
Lentigo maligna 19.30 10.15 22 655961 660 109932656
Blood immunoglobulin G increased 19.28 10.15 58 655925 3750 109929566
Phyllodes tumour 19.23 10.15 10 655973 86 109933230
Subclavian vein thrombosis 19.20 10.15 48 655935 2784 109930532
Haemoglobin abnormal 19.20 10.15 105 655878 8933 109924383
Pseudocellulitis 19.20 10.15 18 655965 427 109932889
Hyphaema 19.17 10.15 28 655955 1079 109932237
Motor dysfunction 19.16 10.15 77 655906 24329 109908987
Spinal cord injury 19.16 10.15 35 655948 1630 109931686
Low density lipoprotein increased 19.11 10.15 21 655962 10645 109922671
Infection in an immunocompromised host 19.08 10.15 38 655945 1889 109931427
Haemolytic anaemia 19.08 10.15 199 655784 20721 109912595
Rash maculo-papular 19.07 10.15 576 655407 73646 109859670
Pulmonary oedema 19.04 10.15 754 655229 99905 109833411
Ventricular tachycardia 19.01 10.15 197 655786 49812 109883504
Plasma cells increased 19.01 10.15 11 655972 119 109933197
Bacterial colitis 18.96 10.15 14 655969 235 109933081
Tinnitus 18.94 10.15 249 655734 60291 109873025
Amoebic colitis 18.85 10.15 11 655972 121 109933195
Benign prostatic hyperplasia 18.82 10.15 51 655932 18183 109915133
Autoimmune disorder 18.82 10.15 274 655709 65209 109868107
Nausea 18.81 10.15 7858 648125 1227832 108705484
Acute polyneuropathy 18.80 10.15 23 655960 745 109932571
Palmar-plantar erythrodysaesthesia syndrome 18.78 10.15 345 655638 40680 109892636
Testicular germ cell cancer metastatic 18.74 10.15 9 655974 64 109933252
Tumour haemorrhage 18.70 10.15 71 655912 5174 109928142
Herpes simplex meningitis 18.66 10.15 10 655973 92 109933224
Hemiparesis 18.65 10.15 365 655618 43538 109889778
Graft versus host disease 18.65 10.15 182 655801 18624 109914692
Cholangiocarcinoma 18.62 10.15 48 655935 2837 109930479
Clostridial sepsis 18.61 10.15 27 655956 1034 109932282
Malignant pleural effusion 18.57 10.15 60 655923 4033 109929283
Viral myelitis 18.55 10.15 11 655972 125 109933191
Chemotherapy 18.53 10.15 40 655943 2106 109931210
Marrow hyperplasia 18.49 10.15 36 655947 1760 109931556
Conjunctivitis allergic 18.44 10.15 9 655974 6922 109926394
Pharyngeal inflammation 18.44 10.15 35 655948 1679 109931637
Gastroenteritis viral 18.43 10.15 109 655874 31117 109902199
Human herpesvirus 7 infection 18.40 10.15 13 655970 203 109933113
Oesophageal adenocarcinoma 18.38 10.15 26 655957 973 109932343
Throat tightness 18.38 10.15 290 655693 33199 109900117
Wrist fracture 18.37 10.15 36 655947 14381 109918935
Hepatic failure 18.35 10.15 536 655447 68203 109865113
Stent placement 18.35 10.15 10 655973 7224 109926092
Blood immunoglobulin D increased 18.34 10.15 5 655978 3 109933313
Anti-cyclic citrullinated peptide antibody 18.32 10.15 59 655924 19905 109913411
CSF oligoclonal band present 18.30 10.15 18 655965 454 109932862
Skin laceration 18.28 10.15 121 655862 33632 109899684
Eastern Cooperative Oncology Group performance status improved 18.28 10.15 6 655977 12 109933304
Administration site extravasation 18.22 10.15 35 655948 1694 109931622
Drug specific antibody present 18.20 10.15 14 655969 8420 109924896
Haemolytic uraemic syndrome 18.20 10.15 68 655915 4917 109928399
SARS-CoV-2 sepsis 18.19 10.15 14 655969 251 109933065
Bone disorder 18.12 10.15 199 655784 20993 109912323
Subileus 18.10 10.15 81 655902 6356 109926960
Aortic arteriosclerosis 18.03 10.15 23 655960 10915 109922401
Brain neoplasm 18.02 10.15 80 655903 6257 109927059
Diverticulitis 17.94 10.15 430 655553 53092 109880224
Hepatosplenomegaly 17.93 10.15 85 655898 6834 109926482
Drooling 17.91 10.15 10 655973 7129 109926187
Aortitis 17.91 10.15 38 655945 1977 109931339
Lupus nephritis 17.90 10.15 3 655980 4642 109928674
Ankle fracture 17.89 10.15 59 655924 19760 109913556
Renal cyst 17.89 10.15 52 655931 18120 109915196
Skin exfoliation 17.80 10.15 390 655593 87261 109846055
Gynaecomastia 17.77 10.15 18 655965 9472 109923844
Coinfection 17.76 10.15 11 655972 136 109933180
Macular hole 17.75 10.15 26 655957 1005 109932311
Infusion related hypersensitivity reaction 17.73 10.15 24 655959 861 109932455
Vitrectomy 17.68 10.15 14 655969 262 109933054
Cyanosis 17.65 10.15 261 655722 29480 109903836
VIth nerve disorder 17.64 10.15 7 655976 29 109933287
Liver transplant 17.61 10.15 3 655980 4586 109928730
Encephalitis enteroviral 17.59 10.15 14 655969 264 109933052
Somnambulism 17.53 10.15 8 655975 6397 109926919
Cerebral venous sinus thrombosis 17.50 10.15 47 655936 2848 109930468
Vena cava thrombosis 17.49 10.15 53 655930 3441 109929875
General symptom 17.47 10.15 16 655967 8830 109924486
Human herpesvirus 8 infection 17.46 10.15 36 655947 1835 109931481
Carotid intima-media thickness increased 17.45 10.15 10 655973 106 109933210
Haematemesis 17.45 10.15 246 655737 58862 109874454
Catabolic state 17.44 10.15 9 655974 76 109933240
Skin candida 17.43 10.15 41 655942 2287 109931029
Radiation inflammation 17.42 10.15 26 655957 1022 109932294
Incorrect route of product administration 17.39 10.15 271 655712 63790 109869526
Catarrh 17.38 10.15 11 655972 7324 109925992
Refractory anaemia with ringed sideroblasts 17.37 10.15 6 655977 15 109933301
Osteochondrosis 17.37 10.15 43 655940 2478 109930838
Electrocardiogram abnormal 17.37 10.15 55 655928 18654 109914662
Blast cells present 17.32 10.15 25 655958 953 109932363
Vertebral column mass 17.27 10.15 15 655968 321 109932995
Corneal epithelium defect 17.17 10.15 24 655959 888 109932428
Adenocarcinoma pancreas 17.10 10.15 40 655943 2223 109931093
Hypophagia 17.10 10.15 421 655562 52205 109881111
Attention deficit hyperactivity disorder 17.09 10.15 3 655980 4488 109928828
Accident 17.07 10.15 24 655959 10928 109922388
Loss of consciousness 17.07 10.15 971 655012 195335 109737981
Prinzmetal angina 17.03 10.15 40 655943 2229 109931087
Genital haemorrhage 17.02 10.15 11 655972 7241 109926075
Photosensitivity reaction 16.93 10.15 86 655897 25503 109907813
5q minus syndrome 16.91 10.15 14 655969 280 109933036
Nasal abscess 16.90 10.15 12 655971 189 109933127
Hand fracture 16.88 10.15 14 655969 8108 109925208
Abnormal behaviour 16.88 10.15 149 655834 38890 109894426
Brain herniation 16.87 10.15 100 655883 8763 109924553
Pulmonary function test decreased 16.87 10.15 16 655967 8684 109924632
Ischaemic stroke 16.84 10.15 341 655642 40922 109892394
Haemolysis 16.83 10.15 154 655829 15485 109917831
Ankle brachial index decreased 16.77 10.15 9 655974 83 109933233
Pulse waveform abnormal 16.77 10.15 9 655974 83 109933233
Hemianopia 16.77 10.15 46 655937 2822 109930494
Enterovirus infection 16.77 10.15 45 655938 2725 109930591
Bronchopneumopathy 16.75 10.15 24 655959 909 109932407
Intracranial mass 16.74 10.15 41 655942 2347 109930969
Streptococcal sepsis 16.73 10.15 67 655916 5005 109928311
Mydriasis 16.71 10.15 71 655912 22086 109911230
Viral mutation identified 16.71 10.15 3 655980 4416 109928900
Epstein Barr virus positive mucocutaneous ulcer 16.67 10.15 27 655956 1140 109932176
Thyrotoxic periodic paralysis 16.64 10.15 12 655971 194 109933122
Oropharyngeal candidiasis 16.63 10.15 37 655946 1989 109931327
Adenovirus infection 16.60 10.15 117 655866 10877 109922439
Plasma cell myeloma in remission 16.60 10.15 7 655976 35 109933281
Blood stem cell harvest 16.60 10.15 7 655976 35 109933281
Precursor B-lymphoblastic lymphoma 16.59 10.15 6 655977 18 109933298
Injury associated with device 16.55 10.15 3 655980 4386 109928930
Drug clearance decreased 16.55 10.15 58 655925 4064 109929252
Ocular toxicity 16.52 10.15 29 655954 1309 109932007
Quadriplegia 16.51 10.15 58 655925 4069 109929247
Cardiomegaly 16.51 10.15 103 655880 29027 109904289
Liver abscess 16.50 10.15 90 655893 7649 109925667
Cavernous sinus thrombosis 16.49 10.15 17 655966 454 109932862
Vaccination failure 16.49 10.15 42 655941 2464 109930852
Haemophilus infection 16.46 10.15 45 655938 2755 109930561
Bile acid malabsorption 16.40 10.15 17 655966 457 109932859
Mastoiditis 16.40 10.15 43 655940 2568 109930748
JC virus CSF test positive 16.38 10.15 12 655971 199 109933117
Bing-Neel syndrome 16.35 10.15 6 655977 19 109933297
Cataract traumatic 16.33 10.15 5 655978 7 109933309
Cerebellar haemangioma 16.33 10.15 9 655974 88 109933228
Dermatitis acneiform 16.29 10.15 130 655853 12565 109920751
Sinusitis fungal 16.28 10.15 44 655939 2676 109930640
Colorectal cancer 16.27 10.15 18 655965 9096 109924220
Enterobacter sepsis 16.24 10.15 29 655954 1327 109931989
Transplant 16.23 10.15 28 655955 1246 109932070
Tenderness 16.21 10.15 105 655878 29332 109903984
BK virus infection 16.16 10.15 133 655850 12973 109920343
Blood potassium increased 16.15 10.15 123 655860 33126 109900190
Vitreous opacities 16.15 10.15 23 655960 866 109932450
Conjunctival hyperaemia 16.12 10.15 73 655910 5758 109927558
Postictal state 16.10 10.15 41 655942 2405 109930911
Natural killer-cell lymphoblastic lymphoma 16.08 10.15 8 655975 62 109933254
Ocular lymphoma 16.08 10.15 12 655971 205 109933111
Anti-neutrophil cytoplasmic antibody positive vasculitis 16.06 10.15 6 655977 5411 109927905
Pelvic abscess 16.03 10.15 43 655940 2603 109930713
Normal newborn 16.00 10.15 71 655912 21825 109911491
POEMS syndrome 15.98 10.15 8 655975 63 109933253
Vitritis 15.96 10.15 43 655940 2610 109930706
Hepatic cytolysis 15.94 10.15 230 655753 54823 109878493
Stress echocardiogram abnormal 15.94 10.15 5 655978 8 109933308
Adrenomegaly 15.90 10.15 17 655966 474 109932842
Peritumoural oedema 15.90 10.15 6 655977 21 109933295
Middle insomnia 15.90 10.15 65 655918 20437 109912879
Drug level below therapeutic 15.89 10.15 28 655955 11645 109921671
Pleocytosis 15.89 10.15 33 655950 1691 109931625
Dyspnoea 15.87 10.15 7025 648958 1099847 108833469
Pulmonary trichosporonosis 15.87 10.15 8 655975 64 109933252
Intestinal atresia 15.87 10.15 8 655975 64 109933252
Therapeutic response unexpected 15.85 10.15 80 655903 23763 109909553
Miliary pneumonia 15.84 10.15 7 655976 40 109933276
Blood prolactin increased 15.82 10.15 4 655979 4638 109928678
Nerve compression 15.82 10.15 26 655957 11111 109922205
Body dysmorphic disorder 15.78 10.15 16 655967 419 109932897
Aspiration 15.77 10.15 111 655872 30422 109902894
Dysaesthesia pharynx 15.74 10.15 13 655970 259 109933057
Foetal death 15.73 10.15 46 655937 15999 109917317
Infantile apnoea 15.70 10.15 7 655976 41 109933275
Subcutaneous emphysema 15.67 10.15 42 655941 2542 109930774
Nail dystrophy 15.66 10.15 27 655956 1201 109932115
Sacroiliitis 15.65 10.15 5 655978 4973 109928343
Hernia 15.64 10.15 61 655922 19439 109913877
Paraparesis 15.61 10.15 61 655922 4505 109928811
Diverticulum 15.60 10.15 44 655939 15482 109917834
Molluscum contagiosum 15.59 10.15 19 655964 613 109932703
Pneumonia pseudomonal 15.58 10.15 87 655896 7459 109925857
Ependymitis 15.57 10.15 5 655978 9 109933307
Ileal perforation 15.57 10.15 29 655954 1371 109931945
Uterine leiomyoma 15.53 10.15 14 655969 7786 109925530
Peritonitis bacterial 15.52 10.15 24 655959 10509 109922807
Tonsillar disorder 15.52 10.15 30 655953 1459 109931857
Post procedural hypotension 15.50 10.15 9 655974 98 109933218
Retinal degeneration 15.48 10.15 32 655951 1634 109931682
Nail bed inflammation 15.47 10.15 36 655947 1994 109931322
Corneal abscess 15.46 10.15 8 655975 68 109933248
Mycotic endophthalmitis 15.44 10.15 16 655967 430 109932886
Acute leukaemia 15.44 10.15 34 655949 1815 109931501
Factor VII deficiency 15.42 10.15 9 655974 99 109933217
Scar 15.41 10.15 50 655933 16831 109916485
Osteomyelitis bacterial 15.40 10.15 18 655965 555 109932761
Product packaging confusion 15.39 10.15 15 655968 374 109932942
Quadriparesis 15.38 10.15 62 655921 4645 109928671
Hypoproteinaemia 15.38 10.15 73 655910 5872 109927444
Lymphadenitis 15.36 10.15 69 655914 5424 109927892
Corneal lesion 15.35 10.15 9 655974 100 109933216
Septic embolus 15.32 10.15 39 655944 2287 109931029
Blood calcium abnormal 15.30 10.15 33 655950 1736 109931580
Prostate cancer metastatic 15.28 10.15 64 655919 4879 109928437
Focal segmental glomerulosclerosis 15.28 10.15 3 655980 4142 109929174
Cerebral fungal infection 15.26 10.15 20 655963 695 109932621
Orbital infection 15.24 10.15 11 655972 178 109933138
Metastases to bone marrow 15.23 10.15 24 655959 990 109932326
Liver function test increased 15.23 10.15 404 655579 88144 109845172
Dactylitis 15.21 10.15 3 655980 4130 109929186
Mood altered 15.21 10.15 70 655913 21305 109912011
Septic pulmonary embolism 15.18 10.15 14 655969 325 109932991
Liver disorder 15.17 10.15 689 655294 141554 109791762
Abscess fungal 15.15 10.15 16 655967 440 109932876
Cardiogenic shock 15.09 10.15 244 655739 57094 109876222
Macular fibrosis 15.06 10.15 20 655963 704 109932612
Device related thrombosis 15.03 10.15 50 655933 3412 109929904
Diabetes mellitus inadequate control 15.01 10.15 109 655874 29666 109903650
Overlap syndrome 14.98 10.15 19 655964 9040 109924276
Mucocutaneous haemorrhage 14.97 10.15 13 655970 278 109933038
Tumour pseudoprogression 14.97 10.15 31 655952 1585 109931731
Cyst 14.96 10.15 49 655934 16447 109916869
Subcutaneous drug absorption impaired 14.95 10.15 14 655969 7645 109925671
Inability to afford medication 14.92 10.15 3 655980 4073 109929243
Hepatorenal failure 14.91 10.15 28 655955 1332 109931984
Euglycaemic diabetic ketoacidosis 14.83 10.15 29 655954 11594 109921722
Hepatitis G 14.83 10.15 9 655974 107 109933209
Bezoar 14.80 10.15 3 655980 4051 109929265
Adjusted calcium increased 14.80 10.15 8 655975 75 109933241
Vernal keratoconjunctivitis 14.79 10.15 7 655976 48 109933268
Picornavirus infection 14.79 10.15 10 655973 145 109933171
Dyslipidaemia 14.78 10.15 47 655936 15918 109917398
Hyperhidrosis 14.76 10.15 935 655048 186363 109746953
Suffocation feeling 14.76 10.15 36 655947 2055 109931261
Humerus fracture 14.74 10.15 112 655871 10664 109922652
Citrobacter sepsis 14.71 10.15 8 655975 76 109933240
Embedded device 14.69 10.15 3 655980 4030 109929286
Gastroenteritis salmonella 14.69 10.15 28 655955 1347 109931969
Pulmonary cavitation 14.68 10.15 37 655946 2157 109931159
Renal oncocytoma 14.66 10.15 12 655971 236 109933080
Blood test abnormal 14.65 10.15 104 655879 28450 109904866
Swelling face 14.65 10.15 679 655304 91642 109841674
Malignant melanoma 14.62 10.15 159 655824 16732 109916584
Pneumoretroperitoneum 14.59 10.15 11 655972 191 109933125
Radiculopathy 14.56 10.15 62 655921 19274 109914042
Hospice care 14.54 10.15 125 655858 12348 109920968
Angioedema 14.52 10.15 459 655524 98041 109835275
Full blood count increased 14.51 10.15 20 655963 730 109932586
Colon cancer metastatic 14.51 10.15 40 655943 2461 109930855
Metastatic squamous cell carcinoma 14.49 10.15 20 655963 731 109932585
Cryptococcal fungaemia 14.45 10.15 13 655970 292 109933024
Retinal infiltrates 14.43 10.15 7 655976 51 109933265
Spinal stenosis 14.41 10.15 61 655922 18995 109914321
Ventricular fibrillation 14.40 10.15 166 655817 41147 109892169
Cryptosporidiosis infection 14.40 10.15 25 655958 1118 109932198
Bone infarction 14.40 10.15 18 655965 596 109932720
Respiratory depth decreased 14.39 10.15 6 655977 29 109933287
Opportunistic infection 14.35 10.15 50 655933 3493 109929823
Self-injurious ideation 14.33 10.15 4 655979 4342 109928974
Disseminated coccidioidomycosis 14.33 10.15 12 655971 244 109933072
Pseudohyponatraemia 14.30 10.15 11 655972 197 109933119
Toe amputation 14.29 10.15 4 655979 4334 109928982
Cranial nerve palsies multiple 14.28 10.15 12 655971 245 109933071
Vitreous haze 14.28 10.15 9 655974 115 109933201
Amoebiasis 14.27 10.15 10 655973 154 109933162
Pneumoperitoneum 14.26 10.15 54 655929 3930 109929386
TP53 gene mutation 14.22 10.15 10 655973 155 109933161
Ovarian hyperstimulation syndrome 14.20 10.15 7 655976 5353 109927963
Metastases to retroperitoneum 14.18 10.15 15 655968 413 109932903
Adenoviral haemorrhagic cystitis 14.18 10.15 19 655964 675 109932641
Synovial cyst 14.17 10.15 29 655954 11401 109921915
Borrelia infection 14.16 10.15 13 655970 300 109933016
Ischaemic cerebral infarction 14.12 10.15 44 655939 2901 109930415
Amyotrophy 14.09 10.15 19 655964 679 109932637
Mechanical ventilation complication 14.08 10.15 20 655963 751 109932565
Dacryocanaliculitis 14.08 10.15 5 655978 14 109933302
Complications of transplanted kidney 14.07 10.15 14 655969 7428 109925888
Respiratory rate increased 14.05 10.15 89 655894 24994 109908322
Throat irritation 14.05 10.15 228 655755 53324 109879992
Creatinine renal clearance decreased 14.05 10.15 74 655909 21741 109911575
Creatinine renal clearance 13.99 10.15 7 655976 55 109933261
Serum ferritin increased 13.96 10.15 119 655864 11728 109921588
Non-cardiac chest pain 13.95 10.15 106 655877 10092 109923224
Jugular vein occlusion 13.95 10.15 8 655975 85 109933231
Liver function test abnormal 13.94 10.15 307 655676 68643 109864673
Radiation necrosis 13.93 10.15 21 655962 833 109932483
Cardioactive drug level increased 13.91 10.15 3 655980 3879 109929437
Hyperproteinaemia 13.91 10.15 13 655970 307 109933009
Acute hepatitis B 13.91 10.15 17 655966 550 109932766
Gestational diabetes 13.85 10.15 14 655969 7375 109925941
Gastrointestinal inflammation 13.85 10.15 100 655883 9369 109923947
Psychotic symptom 13.84 10.15 3 655980 3864 109929452
Light chain analysis 13.82 10.15 5 655978 15 109933301
Hypergeusia 13.82 10.15 5 655978 15 109933301
Dysstasia 13.78 10.15 127 655856 32859 109900457
Intracardiac thrombus 13.78 10.15 56 655927 4212 109929104
Skin irritation 13.77 10.15 50 655933 16269 109917047
Metastatic lymphoma 13.77 10.15 18 655965 624 109932692
Masked fever 13.77 10.15 6 655977 33 109933283
Plethoric face 13.77 10.15 6 655977 33 109933283
Cytomegalovirus enterocolitis 13.75 10.15 37 655946 2244 109931072
Haemorrhage intracranial 13.75 10.15 245 655738 28724 109904592
Frustration tolerance decreased 13.74 10.15 19 655964 8712 109924604
Alcohol abuse 13.74 10.15 6 655977 4923 109928393
Ataxia 13.71 10.15 253 655730 29855 109903461
Iridocyclitis 13.70 10.15 66 655917 5342 109927974
Streptococcal infection 13.69 10.15 111 655872 10779 109922537
Dyspnoea exertional 13.68 10.15 492 655491 103568 109829748
Cholecystitis chronic 13.66 10.15 22 655961 9478 109923838
Vein discolouration 13.65 10.15 15 655968 432 109932884
Generalised oedema 13.64 10.15 257 655726 30447 109902869
N-terminal prohormone brain natriuretic peptide decreased 13.62 10.15 6 655977 34 109933282
Facial pain 13.61 10.15 46 655937 15293 109918023
Perihepatic abscess 13.59 10.15 10 655973 167 109933149
Janeway lesion 13.59 10.15 5 655978 16 109933300
Calciphylaxis 13.53 10.15 4 655979 4183 109929133
Refractory cancer 13.50 10.15 12 655971 265 109933051
Immunoglobulins increased 13.48 10.15 20 655963 782 109932534
Enterocolitis bacterial 13.41 10.15 19 655964 712 109932604
Weight fluctuation 13.40 10.15 195 655788 21950 109911366
Application site pruritus 13.40 10.15 4 655979 4156 109929160
Balance disorder 13.38 10.15 560 655423 116000 109817316
Pseudomonal skin infection 13.36 10.15 5 655978 17 109933299
Squamous cell carcinoma of the hypopharynx 13.36 10.15 5 655978 17 109933299
Monoclonal gammopathy 13.35 10.15 25 655958 1187 109932129
Gastrointestinal necrosis 13.34 10.15 76 655907 6564 109926752
Aspiration bone marrow 13.34 10.15 10 655973 172 109933144
Oesophageal squamous cell carcinoma 13.33 10.15 16 655967 508 109932808
Menstruation irregular 13.32 10.15 9 655974 5788 109927528
Listeria encephalitis 13.31 10.15 13 655970 325 109932991
Phlebitis 13.30 10.15 102 655881 9739 109923577
Injection site extravasation 13.30 10.15 25 655958 10144 109923172
Staphylococcus test positive 13.30 10.15 82 655901 7288 109926028
Oncologic complication 13.29 10.15 15 655968 445 109932871
Muscle tightness 13.29 10.15 44 655939 14718 109918598
Dental fistula 13.28 10.15 17 655966 577 109932739
Thiopurine methyltransferase decreased 13.27 10.15 13 655970 326 109932990
Pulmonary nocardiosis 13.27 10.15 40 655943 2589 109930727
Activated partial thromboplastin time prolonged 13.25 10.15 78 655905 22290 109911026
Depression suicidal 13.24 10.15 6 655977 4818 109928498
Post procedural infection 13.24 10.15 40 655943 13769 109919547
Alcohol use 13.21 10.15 4 655979 4118 109929198
Radiation oesophagitis 13.21 10.15 21 655962 873 109932443
Joint noise 13.20 10.15 7 655976 5136 109928180
Initial insomnia 13.19 10.15 26 655957 10363 109922953
Sensory loss 13.15 10.15 74 655909 21383 109911933
Cytokine storm 13.13 10.15 28 655955 1462 109931854
Major depression 13.12 10.15 27 655956 10594 109922722
Normochromic normocytic anaemia 13.12 10.15 37 655946 13020 109920296
Histiocytic sarcoma 13.12 10.15 8 655975 96 109933220
Natural killer cell count decreased 13.11 10.15 9 655974 134 109933182
Labelled drug-drug interaction issue 13.11 10.15 4 655979 4097 109929219
Urinary tract infection enterococcal 13.10 10.15 50 655933 3652 109929664
Left ventricular dysfunction 13.10 10.15 204 655779 23289 109910027
Bacterial translocation 13.10 10.15 28 655955 1464 109931852
Transitional cell cancer of the renal pelvis and ureter 13.10 10.15 7 655976 64 109933252
Protein total abnormal 13.07 10.15 19 655964 729 109932587
Endocarditis histoplasma 13.07 10.15 6 655977 38 109933278
Paraesthesia oral 13.06 10.15 132 655851 33539 109899777
Mesenteric vascular insufficiency 13.05 10.15 9 655974 135 109933181
Thyroid disorder 13.03 10.15 54 655929 16915 109916401
Glucose tolerance impaired 13.03 10.15 24 655959 9813 109923503
Pollakiuria 13.02 10.15 184 655799 44011 109889305
Pneumonia necrotising 13.01 10.15 31 655952 1744 109931572
Penile infection 13.00 10.15 7 655976 65 109933251
Gas gangrene 12.99 10.15 13 655970 335 109932981
Meningoencephalitis bacterial 12.98 10.15 15 655968 457 109932859
Abdominal pain lower 12.92 10.15 150 655833 37133 109896183
Mastocytosis 12.92 10.15 20 655963 812 109932504
Prohormone brain natriuretic peptide increased 12.91 10.15 14 655969 397 109932919
Corneal cyst 12.90 10.15 4 655979 6 109933310
Exposure via contaminated device 12.90 10.15 4 655979 6 109933310
Aphasia 12.86 10.15 449 655534 58548 109874768
Debridement 12.85 10.15 32 655951 1851 109931465
Tumour associated fever 12.85 10.15 24 655959 1137 109932179
Oophoritis 12.83 10.15 9 655974 139 109933177
Soft tissue injury 12.81 10.15 36 655947 2240 109931076
Hepatic steatosis 12.78 10.15 208 655775 48623 109884693
Long QT syndrome 12.77 10.15 14 655969 7104 109926212
Clostridium colitis 12.76 10.15 46 655937 3269 109930047
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 12.74 10.15 5 655978 20 109933296
Neurotrophic keratopathy 12.74 10.15 5 655978 20 109933296
Anticipatory anxiety 12.72 10.15 25 655958 1231 109932085
Granuloma 12.71 10.15 23 655960 9467 109923849
White blood cell count increased 12.70 10.15 458 655525 96384 109836932
Bacterial parotitis 12.69 10.15 6 655977 41 109933275
Chloroma 12.64 10.15 20 655963 828 109932488
Alveolitis 12.59 10.15 56 655927 4383 109928933
Product availability issue 12.59 10.15 17 655966 7873 109925443
Adenoviral hepatitis 12.58 10.15 22 655961 990 109932326
Extra dose administered 12.56 10.15 34 655949 12125 109921191
Pulmonary function test abnormal 12.55 10.15 7 655976 4993 109928323
Philadelphia chromosome negative 12.55 10.15 5 655978 21 109933295
Uterine fistula 12.55 10.15 5 655978 21 109933295
Joint destruction 12.55 10.15 29 655954 10914 109922402
Cardiac failure chronic 12.54 10.15 41 655942 13770 109919546
Acanthamoeba keratitis 12.53 10.15 4 655979 7 109933309
Appendiceal abscess 12.52 10.15 14 655969 411 109932905
Biliary tract infection 12.51 10.15 30 655953 1694 109931622
Upper-airway cough syndrome 12.47 10.15 50 655933 15807 109917509
Histoplasmosis disseminated 12.46 10.15 51 655932 3848 109929468
Arthropod bite 12.45 10.15 24 655959 9647 109923669
Increased viscosity of upper respiratory secretion 12.45 10.15 17 655966 615 109932701
Hypercalcaemia of malignancy 12.43 10.15 16 655967 546 109932770
Purine metabolism disorder 12.40 10.15 3 655980 0 109933316
Reoviral infection 12.40 10.15 3 655980 0 109933316
Blood selenium increased 12.40 10.15 3 655980 0 109933316
Sensory ganglionitis 12.40 10.15 3 655980 0 109933316
Fibrin increased 12.40 10.15 3 655980 0 109933316
Eye infarction 12.40 10.15 3 655980 0 109933316
Hymenolepiasis 12.40 10.15 3 655980 0 109933316
Vaccine virus shedding 12.40 10.15 3 655980 0 109933316
Pulpitis dental 12.39 10.15 28 655955 1521 109931795
Coronary artery stenosis 12.39 10.15 41 655942 13717 109919599
Light chain analysis decreased 12.37 10.15 5 655978 22 109933294
Bone marrow leukaemic cell infiltration 12.31 10.15 8 655975 108 109933208
Procedural nausea 12.30 10.15 24 655959 1175 109932141
Tendon disorder 12.28 10.15 19 655964 8318 109924998
Maternal exposure before pregnancy 12.26 10.15 15 655968 7250 109926066
Pulmonary toxicity 12.26 10.15 160 655823 17586 109915730
Intestinal resection 12.26 10.15 4 655979 3925 109929391
Rhinalgia 12.26 10.15 4 655979 3925 109929391
Colony stimulating factor therapy 12.24 10.15 17 655966 625 109932691
Eye excision 12.23 10.15 7 655976 74 109933242
Lung consolidation 12.22 10.15 105 655878 10371 109922945
Cystitis viral 12.20 10.15 27 655956 1446 109931870
Peripheral vascular disorder 12.20 10.15 20 655963 8556 109924760
Local anaesthetic systemic toxicity 12.19 10.15 9 655974 5528 109927788
Fibrin D dimer increased 12.19 10.15 100 655883 9745 109923571
Plasma cells present 12.19 10.15 4 655979 8 109933308
Free fatty acids increased 12.19 10.15 4 655979 8 109933308
Candida sepsis 12.18 10.15 42 655941 2919 109930397
Joint arthroplasty 12.15 10.15 3 655980 3534 109929782
Cataract cortical 12.14 10.15 9 655974 152 109933164
Procalcitonin increased 12.14 10.15 52 655931 4004 109929312
Device deployment issue 12.14 10.15 5 655978 4248 109929068
Gastric polyps 12.13 10.15 9 655974 5514 109927802
Aspergilloma 12.12 10.15 19 655964 780 109932536
Chronic kidney disease 12.11 10.15 352 655631 75939 109857377
Meibomian gland dysfunction 12.09 10.15 12 655971 306 109933010
Heart sounds abnormal 12.09 10.15 27 655956 1455 109931861
Chemical burns of eye 12.07 10.15 8 655975 112 109933204
Leishmaniasis 12.07 10.15 15 655968 494 109932822
Emotional disorder 12.05 10.15 52 655931 16108 109917208
Acute myelomonocytic leukaemia 12.05 10.15 14 655969 429 109932887
Myoglobin blood increased 12.04 10.15 5 655978 4227 109929089
Retinal haemorrhage 12.03 10.15 97 655886 9404 109923912
Vitamin D decreased 11.99 10.15 35 655948 12180 109921136
CNS ventriculitis 11.98 10.15 17 655966 638 109932678
Circulatory collapse 11.96 10.15 337 655646 42656 109890660
Excessive eye blinking 11.95 10.15 31 655952 1839 109931477
Injection site discomfort 11.94 10.15 14 655969 6893 109926423
Radiation mucositis 11.93 10.15 12 655971 311 109933005
Tic 11.92 10.15 3 655980 3490 109929826
Haemophilus sepsis 11.90 10.15 11 655972 256 109933060
Electrophoresis protein abnormal 11.87 10.15 4 655979 9 109933307
Posterior capsule rupture 11.86 10.15 5 655978 25 109933291
Hordeolum 11.83 10.15 59 655924 4842 109928474
Therapy responder 11.82 10.15 14 655969 438 109932878
Respiratory tract infection fungal 11.80 10.15 25 655958 1299 109932017
Chorioretinitis 11.79 10.15 26 655957 1389 109931927
Aspergillus test 11.77 10.15 7 655976 80 109933236
High density lipoprotein decreased 11.77 10.15 10 655973 5723 109927593
Cryptococcal meningoencephalitis 11.76 10.15 13 655970 377 109932939
Device defective 11.73 10.15 4 655979 3818 109929498
Epstein-Barr virus associated lymphoproliferative disorder 11.73 10.15 58 655925 4744 109928572
Cardiac dysfunction 11.71 10.15 70 655913 6153 109927163
Mucous stools 11.70 10.15 14 655969 6833 109926483
Asphyxia 11.70 10.15 44 655939 14171 109919145
Cystitis 11.69 10.15 300 655683 65736 109867580
Giardiasis 11.69 10.15 16 655967 580 109932736
Total lung capacity decreased 11.68 10.15 15 655968 7099 109926217
Shoulder operation 11.68 10.15 3 655980 3442 109929874
Venoocclusive disease 11.68 10.15 71 655912 6279 109927037
Flat anterior chamber of eye 11.66 10.15 9 655974 162 109933154
Chronic inflammatory demyelinating polyradiculoneuropathy 11.66 10.15 34 655949 2161 109931155
Substance-induced mood disorder 11.62 10.15 7 655976 82 109933234
Plantar fasciitis 11.62 10.15 8 655975 5093 109928223
Cancer fatigue 11.59 10.15 13 655970 383 109932933
Hip deformity 11.59 10.15 11 655972 265 109933051
Antinuclear antibody positive 11.59 10.15 23 655960 9145 109924171
Gallbladder disorder 11.59 10.15 75 655908 20954 109912362
Epstein-Barr viraemia 11.58 10.15 47 655936 3532 109929784
Enteric neuropathy 11.58 10.15 4 655979 10 109933306
Hepatic amyloidosis 11.58 10.15 4 655979 10 109933306
Meningeal thickening 11.58 10.15 4 655979 10 109933306
Breast mass 11.57 10.15 19 655964 8122 109925194
Squamous cell carcinoma of head and neck 11.57 10.15 12 655971 323 109932993
Thrombotic thrombocytopenic purpura 11.52 10.15 77 655906 7034 109926282
Periorbital infection 11.52 10.15 9 655974 165 109933151
Haemoglobin increased 11.52 10.15 23 655960 9124 109924192
Laryngeal inflammation 11.51 10.15 12 655971 325 109932991
Leukaemic lymphoma 11.48 10.15 7 655976 84 109933232
Delayed recovery from anaesthesia 11.47 10.15 34 655949 2181 109931135
Scratch 11.47 10.15 39 655944 12940 109920376
Hypokinesia 11.44 10.15 79 655904 21747 109911569
Thalamic infarction 11.44 10.15 25 655958 1327 109931989
Bladder transitional cell carcinoma stage 0 11.43 10.15 8 655975 123 109933193
Enuresis 11.39 10.15 5 655978 4091 109929225
Periorbital cellulitis 11.38 10.15 22 655961 1070 109932246
Parosmia 11.38 10.15 40 655943 13140 109920176
Limb discomfort 11.37 10.15 172 655811 40682 109892634
Paronychia 11.36 10.15 108 655875 10973 109922343
Metastases to spleen 11.35 10.15 19 655964 825 109932491
Electrocardiogram Q waves 11.34 10.15 7 655976 86 109933230
Malignant glioma 11.34 10.15 7 655976 86 109933230
Transitional cell carcinoma 11.33 10.15 43 655940 3132 109930184
Transaminases increased 11.33 10.15 472 655511 62918 109870398
CSF lymphocyte count increased 11.31 10.15 4 655979 11 109933305
Oropharyngeal squamous cell carcinoma 11.30 10.15 12 655971 332 109932984
Refeeding syndrome 11.28 10.15 10 655973 220 109933096
Torsade de pointes 11.27 10.15 83 655900 22517 109910799
Fungal sepsis 11.26 10.15 34 655949 2203 109931113
Skin induration 11.26 10.15 6 655977 4389 109928927
Staphylococcal scalded skin syndrome 11.25 10.15 15 655968 530 109932786
Cognitive disorder 11.22 10.15 415 655568 87096 109846220
CSF test abnormal 11.22 10.15 18 655965 754 109932562
Corneal graft rejection 11.21 10.15 8 655975 127 109933189
Cataract operation 11.20 10.15 11 655972 5872 109927444
Idiopathic pulmonary fibrosis 11.19 10.15 8 655975 4996 109928320
Central nervous system fungal infection 11.18 10.15 16 655967 605 109932711
Sinus pain 11.18 10.15 11 655972 5868 109927448
Colectomy 11.18 10.15 6 655977 4372 109928944
Blood urine present 11.17 10.15 91 655892 24154 109909162
Retinal injury 11.17 10.15 14 655969 465 109932851
Hyperlactacidaemia 11.17 10.15 20 655963 8266 109925050
Ilium fracture 11.16 10.15 11 655972 278 109933038
Duodenal perforation 11.14 10.15 39 655944 2731 109930585
Cogwheel rigidity 11.13 10.15 4 655979 3694 109929622
Thinking abnormal 11.12 10.15 49 655934 15091 109918225
Anal cancer stage 0 11.12 10.15 5 655978 30 109933286
Ischaemic cardiomyopathy 11.10 10.15 19 655964 7992 109925324
Sialoadenitis 11.07 10.15 38 655945 2635 109930681
Cytogenetic abnormality 11.07 10.15 23 655960 1179 109932137
Appendicitis perforated 11.07 10.15 47 655936 3605 109929711
Ultrasound foetal abnormal 11.07 10.15 7 655976 90 109933226
Localised infection 11.06 10.15 184 655799 42864 109890452
Varices oesophageal 11.06 10.15 16 655967 7199 109926117
Limb operation 11.05 10.15 5 655978 4019 109929297
Personality disorder 11.05 10.15 39 655944 12798 109920518
Disseminated cytomegaloviral infection 11.05 10.15 16 655967 612 109932704
Choking 11.04 10.15 49 655934 15061 109918255
Disseminated blastomycosis 11.03 10.15 14 655969 471 109932845
Stomatitis necrotising 11.03 10.15 10 655973 227 109933089
Enlarged uvula 11.01 10.15 14 655969 472 109932844
Post-acute COVID-19 syndrome 11.00 10.15 27 655956 1548 109931768
Tuberculin test positive 10.98 10.15 4 655979 3664 109929652
Breath sounds abnormal 10.96 10.15 97 655886 25307 109908009
Encephalitis viral 10.96 10.15 41 655942 2966 109930350
Muscular weakness 10.96 10.15 1298 654685 247170 109686146
Organising pneumonia 10.95 10.15 131 655852 14112 109919204
Peritonitis viral 10.94 10.15 6 655977 58 109933258
Steroid dependence 10.92 10.15 21 655962 8448 109924868
Lumbar vertebral fracture 10.91 10.15 92 655891 9039 109924277
Product blister packaging issue 10.91 10.15 12 655971 346 109932970
Human anaplasmosis 10.87 10.15 7 655976 93 109933223
Lung squamous cell carcinoma stage III 10.85 10.15 5 655978 32 109933284
Injection site irritation 10.85 10.15 8 655975 4916 109928400
Influenza 10.84 10.15 1154 654829 167947 109765369
Pericardial haemorrhage 10.83 10.15 9 655974 5208 109928108
Aortic thrombosis 10.82 10.15 33 655950 2150 109931166
Tricuspid valve incompetence 10.82 10.15 90 655893 23783 109909533
Product preparation error 10.80 10.15 31 655952 10848 109922468
Uveitis 10.80 10.15 185 655798 21525 109911791
Polychromasia 10.79 10.15 16 655967 625 109932691
Lens dislocation 10.79 10.15 9 655974 182 109933134
Hypogeusia 10.78 10.15 33 655950 2154 109931162
Extravasation 10.77 10.15 57 655926 4788 109928528
Leukaemia 10.77 10.15 79 655904 7439 109925877
Exposed bone in jaw 10.75 10.15 48 655935 3763 109929553
Thoracic vertebral fracture 10.75 10.15 72 655911 6583 109926733
Positron emission tomogram abnormal 10.74 10.15 14 655969 484 109932832
Anticholinergic syndrome 10.73 10.15 6 655977 4274 109929042
Tumour perforation 10.72 10.15 16 655967 629 109932687
Retroperitoneal mass 10.70 10.15 11 655972 293 109933023
Catheter site injury 10.70 10.15 11 655972 293 109933023
Hyperchylomicronaemia 10.69 10.15 6 655977 61 109933255
Embolic pneumonia 10.69 10.15 6 655977 61 109933255
Parotitis 10.68 10.15 42 655941 3111 109930205
Bone cyst 10.67 10.15 4 655979 3599 109929717
Tooth extraction 10.66 10.15 121 655862 12870 109920446
Pachymeningitis 10.63 10.15 14 655969 489 109932827
Lymphocyte adoptive therapy 10.60 10.15 8 655975 139 109933177
Hepatic enzyme 10.60 10.15 9 655974 5154 109928162
Corneal pigmentation 10.60 10.15 4 655979 14 109933302
Keratitis viral 10.60 10.15 4 655979 14 109933302
Restrictive cardiomyopathy 10.60 10.15 21 655962 1040 109932276
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 10.60 10.15 5 655978 34 109933282
Plasmablastic lymphoma 10.58 10.15 18 655965 792 109932524
Tooth erosion 10.58 10.15 13 655970 423 109932893
Colorectal cancer recurrent 10.56 10.15 7 655976 98 109933218
Corneal striae 10.52 10.15 6 655977 63 109933253
Anaphylactoid reaction 10.52 10.15 73 655910 6753 109926563
Creatinine renal clearance abnormal 10.51 10.15 17 655966 717 109932599
Renal replacement therapy 10.50 10.15 9 655974 189 109933127
Blood corticotrophin increased 10.49 10.15 11 655972 300 109933016
Hypertensive crisis 10.48 10.15 203 655780 24169 109909147
Lung cancer metastatic 10.46 10.15 51 655932 4147 109929169
Superior vena cava syndrome 10.46 10.15 24 655959 1317 109931999
Transplant dysfunction 10.44 10.15 21 655962 8307 109925009
Haematoma muscle 10.42 10.15 50 655933 4040 109929276
Keratitis 10.42 10.15 59 655924 5085 109928231
Tumour necrosis 10.41 10.15 35 655948 2401 109930915
Post herpetic neuralgia 10.41 10.15 43 655940 3258 109930058
Cardiac arrest 10.38 10.15 1326 654657 195427 109737889
Cytomegalovirus hepatitis 10.37 10.15 19 655964 887 109932429
Angiocentric lymphoma 10.37 10.15 23 655960 1234 109932082
Head discomfort 10.35 10.15 68 655915 18932 109914384
Impaired gastric emptying 10.35 10.15 42 655941 13233 109920083
Pigmentary glaucoma 10.34 10.15 3 655980 3 109933313
Mood swings 10.34 10.15 86 655897 22726 109910590
Retinal occlusive vasculitis 10.33 10.15 10 655973 247 109933069
Immunodeficiency 10.31 10.15 165 655818 38673 109894643
Gastric ulcer 10.31 10.15 170 655813 39657 109893659
Diabetic neuropathy 10.26 10.15 16 655967 6983 109926333
Menstrual disorder 10.25 10.15 8 655975 4776 109928540
Hydronephrosis 10.25 10.15 176 655807 20489 109912827
Paranoid personality disorder 10.25 10.15 5 655978 37 109933279
Cardiomyopathy 10.24 10.15 266 655717 33259 109900057
Abortion induced 10.24 10.15 20 655963 7999 109925317
Overweight 10.24 10.15 14 655969 6450 109926866
Scedosporium infection 10.23 10.15 35 655948 2423 109930893
Chemotherapeutic drug level increased 10.22 10.15 14 655969 508 109932808
Feeling of body temperature change 10.21 10.15 13 655970 6175 109927141
Hypomania 10.21 10.15 29 655954 10181 109923135
Persistent corneal epithelial defect 10.21 10.15 7 655976 104 109933212
Metastases to muscle 10.19 10.15 12 655971 373 109932943
Tracheobronchitis bacterial 10.19 10.15 4 655979 16 109933300
Gingival erosion 10.18 10.15 8 655975 148 109933168
Hyperthermia malignant 10.17 10.15 48 655935 3852 109929464
Leukaemoid reaction 10.16 10.15 13 655970 441 109932875
Polymyalgia rheumatica 10.16 10.15 14 655969 6428 109926888

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA09 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07CB04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB05 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC D10AA03 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R01AD53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S02CA06 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03BA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA01 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35442 antiparasitic agent
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:37962 adrenergic agent
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50671 antithyroid drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

A01AC Corticosteroids for local oral treatment 3 drugs
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C05AA Corticosteroids 8 drugs
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D07AB Corticosteroids, moderately potent (group II) 12 drugs
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D07CB Corticosteroids, moderately potent, combinations with antibiotics 4 drugs
flumetasonefluorometholonefluprednidenetriamcinolone
D07XB Corticosteroids, moderately potent, other combinations 4 drugs
flumetasonefluorometholonefluprednidenetriamcinolone
D10AA Corticosteroids, combinations for treatment of acne 2 drugs
fluorometholonemethylprednisolone
H02AB Glucocorticoids 15 drugs
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S01BA Corticosteroids, plain 15 drugs
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S01CA Corticosteroids and antiinfectives in combination 11 drugs
betamethasonechloroprednisoneclobetasone butyratefludrocortisone acetatefluocinolone acetonidefluocortolonefluorometholonehydrocortisoneloteprednol etabonatemethylprednisoloneprednisolone
S01CB Corticosteroids/antiinfectives/mydriatics in combination 4 drugs
betamethasonefluorometholonehydrocortisoneprednisolone
S02BA Corticosteroids 4 drugs
betamethasonefluocinolone acetonidehydrocortisoneprednisolone
S02CA Corticosteroids and antiinfectives in combination 6 drugs
fludrocortisone acetateflumetasonefluocinolone acetonidehydrocortisoneprednisolonetriamcinolone
S03BA Corticosteroids 2 drugs
betamethasoneprednisolone
S03CA Corticosteroids and antiinfectives in combination 5 drugs
betamethasonefludrocortisone acetatehydrocortisonemethylprednisoloneprednisolone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Systemic AL amyloidosis indication 23132008
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Punctate keratitis indication 42513006 DOID:12197
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Perforation of cornea indication 74895004
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Central retinal vein occlusion with macular edema indication 232039004
Branch retinal vein occlusion with macular edema indication 232048009
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Infective otitis media indication 312218008
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Allergic otitis externa indication 405821001
Anterior uveitis indication 410692006 DOID:1407
Autoimmune hemolytic anemia indication 413603009 DOID:718
Allergic conjunctivitis indication 473460002 DOID:11204
Otitis Externa Seborrhea indication
Non-infectious Posterior Uveitis indication
Transfusion Reaction Urticaria indication
Staphylococcus Aureus Otitis Externa indication
Tuberculosis Meningitis Treatment Adjunct indication
Synovitis due to Osteoarthritis indication
Otitis Externa Eczema indication
Diagnostic Test for Cushing's Syndrome indication
Erythroblastic Anemia indication
Post-Op Ocular Inflammation indication
Progressive Diffuse Large B-Cell Lymphoma indication
Systemic Dermatomyositis indication
Pericarditis off-label use 3238004 DOID:1787
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Tendinitis off-label use 34840004 DOID:971
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Croup off-label use 71186008 DOID:9395
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Polyarteritis nodosa off-label use 155441006 DOID:9810
Chemotherapy-induced nausea and vomiting off-label use 236084000
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Metastatic Prostate Carcinoma off-label use
Prevention of Post-Operative Nausea and Vomiting off-label use
Prevention of Radiation-Induced Nausea and Vomiting off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Endophthalmitis contraindication 1847009 DOID:4692
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Retinal detachment contraindication 42059000 DOID:5327
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Cattle Primary bovine ketosis Indication
Cattle Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Azium Tablets 0.25 mg Intervet Inc. 1
Azium Aqueous Suspension Veterinary Intervet Inc. 1
Azium Solution Intervet Inc. 1
Naquasone Bolus Intervet Inc. 2
Azium Powder Intervet Inc. 1
Azium Boluses 10 mg Intervet Inc. 1
Tresaderm Dermatologic Solution Boehringer lngelheim Animal Health USA Inc. 3
Azium Oral Solution 2 mg Intervet Inc. 1
Dexium Tablets Bimeda Animal Health Limited 1
Dexameth-A-Vet Injection Bimeda Animal Health Limited 1
Dexameth-A-Vet Bimeda Animal Health Limited 1
Pet Derm III Tablets Kinetic Technologies LLC 1
Dexamethasone Sterile Solution Kinetic Technologies LLC 1
Zonometh Solution Huvepharma EOOD 1
Dexachel Zoetis Inc. 1
Dexamethasone Solution Huvepharma EOOD 1
Dexium Bimeda Animal Health Limited 1
Dexamethasone Injection Sparhawk Laboratories Inc. 1
Dexamethasone Solution Med-Pharmex Inc. 1
Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Dechra Veterinary Products LLC 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.05%;0.3% TOBRADEX ST HARROW EYE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 8101582 Dec. 19, 2027 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.05%;0.3% TOBRADEX ST HARROW EYE N050818 Feb. 13, 2009 RX SUSPENSION/DROPS OPHTHALMIC 7795316 Aug. 3, 2028 USE OF A COMBINATION OF TOBRAMYCIN AND DEXAMETHASONE TO TREAT OCULAR INFLAMMATION WHERE AN INFECTION OR RISK OF INFECTION EXISTS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 8563027 Feb. 12, 2030 DEXTENZA IS APPROVED FOR THE TREATMENT OF OCULAR PAIN FOLLOWING OPHTHALMIC SURGERY
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10028965 May 23, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 10022502 June 22, 2034 TREATMENT OF POSTOPERATIVE INFLAMMATION
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 12150896 Oct. 7, 2036 TREATMENT OF OCULAR INFLAMMATION AND PAIN FOLLOWING OPHTHALMIC SURGERY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 12150896 Oct. 7, 2036 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 11458041 Nov. 16, 2037 TREATMENT OF OCULAR INFLAMMATION AND PAIN FOLLOWING OPHTHALMIC SURGERY
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 11458041 Nov. 16, 2037 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS
20MG HEMADY DEXCEL N211379 Oct. 3, 2019 RX TABLET ORAL 11304961 Dec. 18, 2037 A METHOD OF TREATING ADULTS WITH MULTIPLE MYELOMA USING DEXAMETHASONE IN COMBINATION WITH AN ANTI-MYELOMA PRODUCT
9% DEXYCU KIT EYEPOINT PHARMS N208912 Feb. 9, 2018 RX SUSPENSION INTRAOCULAR 11097061 June 23, 2039 A METHOD OF LOADING MEDICATION INTO A SYRINGE AND DELIVERING THE MEDICATION TO A TREATMENT SITE
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC 12144889 April 26, 2041 TREATMENT OF OCULAR ITCHING ASSOCIATED WITH ALLERGIC CONJUNCTIVITIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
20MG HEMADY DEXCEL N211379 Oct. 3, 2019 RX TABLET ORAL Oct. 3, 2026 INDICATED IN COMBINATION WITH OTHER ANTI-MYELOMA PRODUCTS FOR THE TREATMENT OF ADULTS WITH MULTIPLE MYELOMA (MM)
0.4MG DEXTENZA OCULAR THERAPEUTIX N208742 Nov. 30, 2018 RX INSERT OPHTHALMIC April 7, 2028 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.88 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Interleukin-5 Cytokine IC50 8.46 WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor EC50 9 WOMBAT-PK
Interleukin-4 Cytokine IC50 8.33 WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit beta Kinase IC50 9.30 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit alpha Kinase IC50 9.30 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.89 PDSP
Androgen receptor Transcription factor Ki 4.79 DRUG MATRIX
Fatty acid-binding protein, liver Cytosolic other Ki 4.66 CHEMBL
Progesterone receptor Transcription factor Ki 5.52 DRUG MATRIX
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor AGONIST EC50 6.10 IUPHAR

External reference:

IDSource
4017922 VUID
N0000146273 NUI
D00292 KEGG_DRUG
203704 RXNORM
4017922 VANDF
C0011777 UMLSCUI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
DB01234 DRUGBANK_ID
D003907 MESH_DESCRIPTOR_UI
5743 PUBCHEM_CID
2768 IUPHAR_LIGAND_ID
816 INN_ID
7S5I7G3JQL UNII
4552 MMSL
6848 MMSL
6849 MMSL
d00206 MMSL
002174 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US
7S5I7G3JQL INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
OZURDEX HUMAN PRESCRIPTION DRUG LABEL 1 0023-3348 IMPLANT 0.70 mg INTRAVITREAL NDA 25 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3176 SOLUTION, CONCENTRATE 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-3177 SOLUTION 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4181 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4182 TABLET 1.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4183 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4184 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-4186 TABLET 6 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8174 TABLET 1 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8175 TABLET 4 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8176 TABLET 2 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8179 TABLET 0.50 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8180 TABLET 0.75 mg ORAL ANDA 20 sections
Dexamethasone HUMAN PRESCRIPTION DRUG LABEL 1 0054-8181 TABLET 1.50 mg ORAL ANDA 20 sections