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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	2725	124-94-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: triamcinolone triamcinlon triamcinolon rodinolone	A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) Molecular weight: 394.44 Formula: C21H27FO6 CLOGP: 0.71 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 115.06 ALOGS: -2.67 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

triamcinolone
triamcinlon
triamcinolon
rodinolone

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Molecular weight: 394.44
Formula: C21H27FO6
CLOGP: 0.71
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 115.06
ALOGS: -2.67
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
7.50	mg	O
7.50	mg	P
0.22	mg	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.08 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	23 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	1.285		Moderate	0.70
caco2-efflux	Caco-2 efflux ratio (BA/AB)	11.749		Moderate	0.70
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	4.457	10^-6 cm/s	Moderate	0.70
dh-clint	Dog hepatocyte intrinsic clearance	2.723	uL/min/10^6 cells	Moderate	0.70
dppb	Dog plasma protein binding (% unbound)	60.820	%	Moderate	0.70
fcs-ppb	Fetal calf serum protein binding (% unbound)	66.460	%	Moderate	0.70
herg	hERG pIC50	4.273	pIC50	Moderate	0.70
hh-clint	Human hepatocyte intrinsic clearance	1.656	uL/min/10^6 cells	Moderate	0.70
hlm-clint	Human liver microsomal intrinsic clearance	4.365	uL/min/mg protein	Moderate	0.70
hppb	Human plasma protein binding (% unbound)	48.730	%	Moderate	0.70
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAPK10,PDK1,PDK2,PDK4,PRKDC	11
kinase-selectivity-class	AXL,GRK2,MAP2K6,MAP3K14	4
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	2.270		High	0.86
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	4.786		Moderate	0.70
mh-clint	Mouse hepatocyte intrinsic clearance	9.268		Moderate	0.70
mppb	Mouse plasma protein binding (% unbound)	57.260		Moderate	0.70
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	8.913		Moderate	0.70
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	0		High	0.86
pppb	Pig plasma protein binding (% unbound)	59.050	%	Moderate	0.70
rat-kpuu-brain	Rat brain Kpuu	0.020	%	High	0.86
rh-clint	Rat hepatocyte intrinsic clearance	6.109	uL/min/10^6 cells	Moderate	0.70
rh-fuinc	Rat hepatocyte fraction unbound in incubation	82.650	%	Moderate	0.70
rppb	Rat plasma protein binding (% unbound)	36.690	%	Moderate	0.70
solubility-dd	Solubility at pH 7.4 in DMSO	586.138	uM	Moderate	0.70

Approvals:

Date	Agency	Company	Orphan
Dec. 3, 1957	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	632.03	13.68	305	57104	23167	90547871
Drug ineffective	580.91	13.68	2051	55358	1382247	89188791
Adrenal insufficiency	466.74	13.68	270	57139	29651	90541387
Psoriasis	419.46	13.68	492	56917	147262	90423776
Polyarthritis	336.07	13.68	184	57225	18166	90552872
Joint destruction	322.76	13.68	161	57248	13126	90557912
Therapeutic product effect incomplete	298.20	13.68	480	56929	193416	90377622
Product use in unapproved indication	279.84	13.68	641	56768	335595	90235443
Obesity	245.41	13.68	318	57091	105189	90465849
Skin exfoliation	231.58	13.68	249	57160	67664	90503374
Body height below normal	214.50	13.68	72	57337	2096	90568942
Human antichimeric antibody positive	199.48	13.68	65	57344	1721	90569317
Drug tolerance	179.19	13.68	122	57287	17794	90553244
Infusion site reaction	174.81	13.68	123	57286	18916	90552122
Papule	171.16	13.68	89	57320	7913	90563125
Immunodeficiency	162.48	13.68	167	57242	43067	90527971
Wheelchair user	156.31	13.68	83	57326	7702	90563336
Skin plaque	150.15	13.68	88	57321	9887	90561151
Eczema	149.69	13.68	176	57233	52694	90518344
Onychomadesis	135.02	13.68	156	57253	45842	90525196
Gastroenteritis viral	133.97	13.68	128	57281	30227	90540811
Sleep disorder due to a general medical condition	133.46	13.68	153	57256	44585	90526453
Macular degeneration	132.53	13.68	141	57268	37829	90533209
Dry skin	132.41	13.68	216	57193	87857	90483181
Therapy non-responder	129.67	13.68	275	57134	136429	90434609
Sleep disorder	127.87	13.68	343	57066	197687	90373351
Back injury	123.43	13.68	150	57259	46472	90524566
Taste disorder	116.54	13.68	168	57241	61378	90509660
Pruritus	115.83	13.68	660	56749	540865	90030173
Blepharospasm	114.85	13.68	158	57251	55287	90515751
Impaired quality of life	108.65	13.68	101	57308	23043	90547995
Psoriatic arthropathy	105.19	13.68	351	57058	227984	90343054
Toxicity to various agents	103.98	13.68	27	57382	287819	90283219
Red blood cell sedimentation rate abnormal	99.18	13.68	98	57311	24106	90546932
Nodule	98.30	13.68	102	57307	26584	90544454
Drug specific antibody	97.08	13.68	42	57367	2470	90568568
Antibody test positive	96.33	13.68	44	57365	2945	90568093
Product quality issue	95.00	13.68	176	57233	79149	90491889
Treatment failure	89.10	13.68	405	57004	303523	90267515
Hypocalcaemia	88.14	13.68	121	57288	42247	90528791
Death	86.56	13.68	97	57312	456454	90114584
Rash	86.29	13.68	825	56584	795275	89775763
Bone density decreased	85.90	13.68	78	57331	17267	90553771
Epilepsy	82.15	13.68	169	57240	82037	90489001
Acute kidney injury	81.71	13.68	51	57358	320336	90250702
Septic shock	80.57	13.68	170	57239	83990	90487048
Ankle arthroplasty	79.84	13.68	38	57371	2793	90568245
Dyspnoea	74.96	13.68	296	57113	880659	89690379
Breast cancer stage III	68.89	13.68	160	57249	84287	90486751
Peripheral venous disease	68.46	13.68	159	57250	83762	90487276
Drug ineffective for unapproved indication	67.75	13.68	138	57271	66506	90504532
Facet joint syndrome	66.05	13.68	173	57236	98216	90472822
Neutropenia	65.84	13.68	30	57379	224874	90346164
Seborrhoeic keratosis	64.11	13.68	34	57375	3146	90567892
Quality of life decreased	63.91	13.68	56	57353	11833	90559205
Therapeutic product effect decreased	63.62	13.68	345	57064	277226	90293812
Vaginal flatulence	62.91	13.68	57	57352	12581	90558457
Intentional product use issue	62.75	13.68	288	57121	216604	90354434
Erythema	60.92	13.68	297	57112	228949	90342089
Injection site atrophy	60.32	13.68	22	57387	822	90570216
Mobility decreased	57.69	13.68	312	57097	250422	90320616
Macule	55.12	13.68	29	57380	2640	90568398
Dermatitis	54.79	13.68	69	57340	22151	90548887
Liver function test increased	54.72	13.68	147	57262	84708	90486330
Synovitis	54.15	13.68	376	57033	329376	90241662
Proctitis	53.83	13.68	57	57352	15202	90555836
Short stature	51.78	13.68	21	57388	1049	90569989
Hidradenitis	51.72	13.68	33	57376	4314	90566724
Limb discomfort	51.38	13.68	89	57320	37971	90533067
Product dose omission in error	51.08	13.68	64	57345	20439	90550599
Chronic sinusitis	51.05	13.68	69	57340	23733	90547305
Thrombocytopenia	50.78	13.68	35	57374	208690	90362348
C-reactive protein increased	50.34	13.68	238	57171	181151	90389887
Female genital tract fistula	49.75	13.68	59	57350	17809	90553229
Normal newborn	49.00	13.68	67	57342	23295	90547743
Hypothalamic pituitary adrenal axis suppression	48.96	13.68	15	57394	323	90570715
Skin discomfort	48.78	13.68	24	57385	1897	90569141
Nail disorder	48.26	13.68	112	57297	58955	90512083
Neck pain	47.88	13.68	170	57239	113793	90457245
Malignant neoplasm progression	47.19	13.68	6	57403	106864	90464174
Radiculopathy	46.48	13.68	58	57351	18447	90552591
Skin fissures	45.66	13.68	61	57348	20748	90550290
Intentional overdose	44.67	13.68	4	57405	93830	90477208
Arthritis	44.59	13.68	217	57192	167098	90403940
Guttate psoriasis	44.46	13.68	16	57393	575	90570463
Foot operation	43.64	13.68	40	57369	8961	90562077
Therapeutic product ineffective	43.61	13.68	24	57385	2390	90568648
Febrile neutropenia	43.49	13.68	23	57386	158326	90412712
Bursitis	42.73	13.68	181	57228	131473	90439565
Paraesthesia oral	42.70	13.68	74	57335	31585	90539453
Vaginal discharge	42.62	13.68	57	57352	19407	90551631
Fibromyalgia	42.35	13.68	249	57160	206020	90365018
Chest pain	42.11	13.68	87	57322	319558	90251480
Skin lesion	41.13	13.68	80	57329	37285	90533753
Wound infection	40.72	13.68	154	57255	106248	90464790
Rapidly progressive osteoarthritis	40.63	13.68	8	57401	21	90571017
Fall	40.14	13.68	163	57246	481647	90089391
Anti-cyclic citrullinated peptide antibody positive	39.61	13.68	271	57138	236162	90334876
Hypercholesterolaemia	38.58	13.68	146	57263	100746	90470292
Dehydration	38.25	13.68	40	57369	194407	90376631
Fatigue	38.20	13.68	509	56900	1153514	89417524
Seizure	37.91	13.68	25	57384	152604	90418434
Bone density increased	37.77	13.68	16	57393	893	90570145
Live birth	36.71	13.68	122	57287	78985	90492053
Seborrhoeic dermatitis	36.41	13.68	19	57390	1701	90569337
Gastrooesophageal reflux disease	36.23	13.68	204	57205	166133	90404905
Bursitis infective	35.79	13.68	18	57391	1492	90569546
Night sweats	35.75	13.68	169	57240	128597	90442441
Foot deformity	35.14	13.68	100	57309	59551	90511487
Electrocardiogram QT prolonged	34.73	13.68	3	57406	72453	90498585
Pustule	34.58	13.68	22	57387	2861	90568177
Cough	34.51	13.68	119	57290	368843	90202195
Pulmonary fibrosis	34.27	13.68	147	57262	107356	90463682
Gait inability	34.16	13.68	183	57226	146273	90424765
Eye infection toxoplasmal	33.92	13.68	12	57397	410	90570628
Procedural pain	33.80	13.68	69	57340	33291	90537747
Skin atrophy	33.71	13.68	28	57381	5501	90565537
Secondary adrenocortical insufficiency	33.70	13.68	20	57389	2298	90568740
Hypokalaemia	33.47	13.68	168	57241	130948	90440090
Cardiac failure	32.98	13.68	14	57395	109482	90461556
Lip dry	32.91	13.68	139	57270	100816	90470222
Xerosis	32.87	13.68	17	57392	1494	90569544
Cardiac arrest	32.28	13.68	13	57396	104922	90466116
Haemoglobin decreased	32.20	13.68	33	57376	161923	90409115
Urinary tract infection	31.77	13.68	94	57315	305538	90265500
Dry mouth	31.43	13.68	212	57197	183847	90387191
Contraindicated product administered	30.73	13.68	324	57085	319815	90251223
Overdose	30.39	13.68	33	57376	157676	90413362
Bradycardia	29.99	13.68	8	57401	83839	90487199
Alanine aminotransferase increased	29.91	13.68	19	57390	118319	90452719
Loss of consciousness	29.88	13.68	171	57238	140067	90430971
Adrenal suppression	29.85	13.68	14	57395	995	90570043
Cardio-respiratory arrest	29.24	13.68	3	57406	63137	90507901
Hyponatraemia	29.15	13.68	25	57384	133513	90437525
Pain of skin	29.12	13.68	43	57366	16039	90554999
Neurodermatitis	28.75	13.68	20	57389	3018	90568020
Chorioretinopathy	28.50	13.68	13	57396	867	90570171
Ocular hypertension	28.43	13.68	16	57393	1664	90569374
Depressed level of consciousness	27.88	13.68	6	57403	72778	90498260
Drug hypersensitivity	27.80	13.68	430	56979	463179	90107859
Coma	27.80	13.68	6	57403	72626	90498412
Rash pruritic	27.42	13.68	114	57295	82100	90488938
Cerebrovascular accident	27.12	13.68	23	57386	123510	90447528
Palpitations	27.02	13.68	28	57381	136700	90434338
Renal failure	26.84	13.68	26	57383	130981	90440057
Pulmonary embolism	26.76	13.68	26	57383	130794	90440244
Perioral dermatitis	26.56	13.68	11	57398	580	90570458
Necrotising fasciitis	26.51	13.68	21	57388	3859	90567179
Gastrointestinal haemorrhage	26.45	13.68	12	57397	90236	90480802
Oedema peripheral	26.32	13.68	80	57329	257835	90313203
Anaemia	25.94	13.68	125	57284	352677	90218361
Hyperhidrosis	25.73	13.68	29	57380	136276	90434762
Skin irritation	25.54	13.68	37	57372	13566	90557472
Oral candidiasis	25.49	13.68	64	57345	35391	90535647
Plastic surgery	25.21	13.68	7	57402	105	90570933
Somnolence	24.98	13.68	60	57349	209024	90362014
Syncope	24.21	13.68	29	57380	132634	90438404
Pleural effusion	24.14	13.68	137	57272	111854	90459184
Blood pressure systolic increased	24.07	13.68	4	57405	58341	90512697
Rhegmatogenous retinal detachment	23.77	13.68	7	57402	131	90570907
Respiratory failure	23.69	13.68	24	57385	118394	90452644
Hyperkalaemia	23.61	13.68	6	57403	64958	90506080
Oxygen saturation decreased	23.61	13.68	20	57389	107463	90463575
Hypersensitivity	23.51	13.68	180	57229	454497	90116541
Tractional retinal detachment	23.49	13.68	6	57403	64	90570974
Pancytopenia	23.35	13.68	25	57384	120238	90450800
Frequent bowel movements	23.11	13.68	84	57325	56851	90514187
Skin burning sensation	22.82	13.68	43	57366	19568	90551470
Human anti-human antibody test	22.79	13.68	9	57400	419	90570619
Choroiditis	22.54	13.68	8	57401	276	90570762
Pyloric abscess	22.22	13.68	4	57405	5	90571033
Drug intolerance	22.01	13.68	402	57007	447189	90123849
Skin odour abnormal	22.00	13.68	14	57395	1821	90569217
Birdshot chorioretinopathy	22.00	13.68	6	57403	84	90570954
Steroid withdrawal syndrome	21.94	13.68	10	57399	666	90570372
Myocardial infarction	21.74	13.68	21	57388	105951	90465087
Retinal artery occlusion	21.61	13.68	15	57394	2256	90568782
Aspartate aminotransferase increased	21.59	13.68	20	57389	102917	90468121
Type 2 diabetes mellitus	21.55	13.68	210	57199	203034	90368004
White blood cell count decreased	21.55	13.68	46	57363	167063	90403975
Necrotising scleritis	21.46	13.68	7	57402	186	90570852
Mycotic endophthalmitis	21.28	13.68	7	57402	191	90570847
Back pain	21.26	13.68	116	57293	317059	90253979
Microsporidia infection	21.00	13.68	8	57401	338	90570700
Drug interaction	20.87	13.68	97	57312	276356	90294682
Cognitive disorder	20.70	13.68	9	57400	69398	90501640
Musculoskeletal stiffness	20.68	13.68	107	57302	296425	90274613
Lung disorder	20.63	13.68	164	57245	149719	90421319
Therapeutic response shortened	20.49	13.68	45	57364	22834	90548204
Scratch	20.25	13.68	28	57381	9838	90561200
Deep vein thrombosis	20.18	13.68	17	57392	91603	90479435
Multiple organ dysfunction syndrome	20.16	13.68	9	57400	68327	90502711
Feeling abnormal	19.97	13.68	48	57361	167187	90403851
Dermatitis contact	19.95	13.68	33	57376	13562	90557476
Rebound effect	19.81	13.68	27	57382	9357	90561681
Blood creatinine increased	19.77	13.68	21	57388	101365	90469673
Folliculitis	19.67	13.68	207	57202	204146	90366892
Lactic acidosis	19.66	13.68	4	57405	50459	90520579
Colitis ulcerative	19.65	13.68	83	57326	60183	90510855
Chest discomfort	19.64	13.68	36	57373	138329	90432709
Sinusitis	19.58	13.68	132	57277	342956	90228082
Infectious crystalline keratopathy	19.24	13.68	4	57405	15	90571023
Lentigo	19.20	13.68	9	57400	639	90570399
Eye irritation	19.08	13.68	56	57353	33922	90537116
Hallucination	18.97	13.68	9	57400	65950	90505088
Blood pressure fluctuation	18.74	13.68	5	57404	52408	90518630
Pseudomeningocele	18.31	13.68	4	57405	20	90571018
Tachycardia	18.24	13.68	46	57363	157627	90413411
Heart rate increased	18.23	13.68	27	57382	112875	90458163
Scar	18.22	13.68	34	57375	15361	90555677
Rhabdomyolysis	18.12	13.68	5	57404	51251	90519787
Pneumonia	18.02	13.68	290	57119	637769	89933269
International normalised ratio increased	17.92	13.68	4	57405	47312	90523726
Lipoatrophy	17.89	13.68	7	57402	318	90570720
Suicide attempt	17.86	13.68	13	57396	75386	90495652
Skin discolouration	17.66	13.68	65	57344	44250	90526788
Gait disturbance	17.60	13.68	95	57314	260401	90310637
Dystrophic calcification	17.45	13.68	6	57403	188	90570850
Myalgia	17.37	13.68	55	57354	175070	90395968
Epistaxis	17.31	13.68	17	57392	85108	90485930
Joint swelling	17.29	13.68	220	57189	503080	90067958
Dermatitis psoriasiform	17.27	13.68	14	57395	2658	90568380
Renal impairment	17.23	13.68	25	57384	105396	90465642
Pigmentation disorder	17.15	13.68	20	57389	5929	90565109
Hepatotoxicity	17.12	13.68	4	57405	45838	90525200
Condition aggravated	17.11	13.68	496	56913	595049	89975989
Speech disorder	16.98	13.68	4	57405	45581	90525457
Angioedema	16.97	13.68	10	57399	64866	90506172
Metabolic acidosis	16.96	13.68	7	57402	55669	90515369
Joint range of motion decreased	16.83	13.68	145	57264	135498	90435540
Neuropathy peripheral	16.60	13.68	39	57370	136931	90434107
Flushing	16.51	13.68	19	57390	88472	90482566
Dysarthria	16.35	13.68	7	57402	54475	90516563
Contusion	16.22	13.68	93	57316	251123	90319915
Autoimmune lung disease	16.13	13.68	5	57404	112	90570926
Orbital infection	16.13	13.68	5	57404	112	90570926
Cardiac disorder	15.99	13.68	8	57401	56864	90514174
Tremor	15.98	13.68	47	57362	153126	90417912
Haemangioma of skin	15.92	13.68	8	57401	662	90570376
Platelet count decreased	15.81	13.68	40	57369	136929	90434109
Soft tissue atrophy	15.80	13.68	4	57405	41	90570997
Keratopathy	15.50	13.68	8	57401	700	90570338
Angina pectoris	15.47	13.68	3	57406	39157	90531881
Urticaria	15.39	13.68	281	57128	312453	90258585
Cataract subcapsular	15.26	13.68	8	57401	723	90570315
Multiple sclerosis relapse	15.26	13.68	7	57402	52298	90518740
Premature delivery	15.25	13.68	3	57406	38759	90532279
Dysphagia	15.24	13.68	30	57379	112248	90458790
Product contamination microbial	15.18	13.68	6	57403	280	90570758
Skin mass	15.12	13.68	21	57388	7409	90563629
Cerebrospinal fistula	14.94	13.68	3	57406	9	90571029
Balance disorder	14.93	13.68	24	57385	97056	90473982
Non-infectious endophthalmitis	14.79	13.68	6	57403	300	90570738
Osteoarthritis	14.70	13.68	189	57220	195541	90375497
Abortion spontaneous	14.62	13.68	8	57401	54048	90516990
Inflammation	14.51	13.68	175	57234	178417	90392621
Musculoskeletal pain	14.44	13.68	169	57240	171082	90399956
Melanocytic naevus	14.23	13.68	17	57392	5169	90565869
Depression	14.06	13.68	268	57141	300333	90270705
Full blood count abnormal	14.05	13.68	3	57406	36594	90534444
Articular calcification	13.88	13.68	5	57404	180	90570858
Hepatic function abnormal	13.81	13.68	6	57403	46282	90524756
Type V hyperlipidaemia	13.80	13.68	8	57401	880	90570158
Product use issue	13.72	13.68	289	57120	329630	90241408

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	1086.05	17.24	1292	16046	628905	41975092
Dermatitis atopic	571.79	17.24	208	17130	12196	42591801
Pruritus	431.91	17.24	453	16885	188318	42415679
Skin exfoliation	339.63	17.24	211	17127	41342	42562655
Rash	314.82	17.24	468	16870	276486	42327511
Product use in unapproved indication	247.77	17.24	338	17000	184118	42419879
Sleep disorder due to a general medical condition	246.80	17.24	127	17211	17326	42586671
Therapeutic product effect incomplete	224.72	17.24	204	17134	70735	42533262
Treatment failure	222.08	17.24	192	17146	62432	42541565
Psoriasis	218.35	17.24	171	17167	48433	42555564
Dry skin	189.37	17.24	157	17181	48181	42555816
Skin plaque	182.71	17.24	74	17264	5789	42598208
Discomfort	175.93	17.24	116	17222	25103	42578894
Papule	166.11	17.24	69	17269	5757	42598240
Eczema	159.69	17.24	123	17215	33963	42570034
Sleep disorder	112.09	17.24	117	17221	47978	42556019
Skin fissures	107.48	17.24	60	17278	9616	42594381
Psoriatic arthropathy	89.27	17.24	77	17261	24890	42579107
Macule	82.17	17.24	31	17307	2004	42601993
Product dose omission issue	77.03	17.24	184	17154	154181	42449816
Nightmare	75.28	17.24	70	17268	24942	42579055
Product dose omission in error	74.70	17.24	45	17293	8309	42595688
Deposit eye	74.57	17.24	13	17325	25	42603972
Skin haemorrhage	71.87	17.24	43	17295	7842	42596155
Therapeutic product ineffective	71.51	17.24	24	17314	1101	42602896
Erythema	66.91	17.24	141	17197	108652	42495345
Skin discomfort	64.35	17.24	20	17318	716	42603281
Dermatitis	62.55	17.24	46	17292	11829	42592168
Guttate psoriasis	60.70	17.24	18	17320	548	42603449
Myoclonic epilepsy	58.65	17.24	23	17315	1651	42602346
Sedation	58.53	17.24	67	17271	30408	42573589
Skin irritation	58.08	17.24	37	17301	7537	42596460
Product compounding quality issue	57.44	17.24	10	17328	19	42603978
Skin lesion	56.04	17.24	62	17276	27112	42576885
Mycotic endophthalmitis	55.86	17.24	14	17324	222	42603775
Off label use	55.39	17.24	445	16893	637890	41966107
Eye pruritus	52.99	17.24	41	17297	11371	42592626
Cerebrospinal fistula	52.08	17.24	9	17329	16	42603981
Adrenal insufficiency	51.30	17.24	50	17288	18874	42585123
Dermatitis psoriasiform	50.12	17.24	22	17316	2100	42601897
Xerosis	48.33	17.24	17	17321	899	42603098
Seborrhoeic keratosis	48.33	17.24	20	17318	1651	42602346
Ocular hypertension	48.32	17.24	18	17320	1123	42602874
Drug ineffective for unapproved indication	46.35	17.24	74	17264	46089	42557908
Rash erythematous	46.17	17.24	61	17277	32030	42571967
Eye irritation	44.74	17.24	37	17301	11281	42592716
Toxicity to various agents	44.15	17.24	19	17319	229117	42374880
Pseudomeningocele	42.90	17.24	8	17330	26	42603971
Endophthalmitis	42.55	17.24	25	17313	4408	42599589
Hyperhidrosis	41.99	17.24	105	17233	90407	42513590
Injection site pain	40.35	17.24	79	17259	57719	42546278
Non-infectious endophthalmitis	39.91	17.24	11	17327	256	42603741
Product contamination microbial	39.88	17.24	14	17324	736	42603261
Impaired quality of life	39.44	17.24	38	17300	14139	42589858
Arthralgia	38.99	17.24	176	17162	205062	42398935
Transmission of an infectious agent via product	38.71	17.24	10	17328	180	42603817
Hypothalamic pituitary adrenal axis suppression	38.53	17.24	11	17327	292	42603705
Lentigo	38.43	17.24	14	17324	820	42603177
Steroid withdrawal syndrome	38.32	17.24	11	17327	298	42603699
Mediastinal abscess	36.69	17.24	8	17330	66	42603931
Perioral dermatitis	36.56	17.24	10	17328	226	42603771
Visual acuity reduced	36.10	17.24	40	17298	17510	42586487
Skin weeping	36.09	17.24	16	17322	1563	42602434
Ocular hyperaemia	35.66	17.24	38	17300	15925	42588072
Therapeutic response decreased	35.33	17.24	58	17280	36954	42567043
General physical health deterioration	35.31	17.24	9	17329	151237	42452760
Rhegmatogenous retinal detachment	33.76	17.24	8	17330	99	42603898
Skin hyperpigmentation	33.49	17.24	21	17317	4160	42599837
Therapeutic response shortened	33.39	17.24	34	17304	13520	42590477
Anaemia	33.34	17.24	39	17299	280239	42323758
Dry eye	33.04	17.24	36	17302	15470	42588527
Skin burning sensation	32.82	17.24	26	17312	7461	42596536
Glaucoma	32.68	17.24	27	17311	8221	42595776
Skin swelling	32.58	17.24	18	17320	2824	42601173
Photodermatosis	32.22	17.24	12	17326	748	42603249
Skin discolouration	32.05	17.24	41	17297	20849	42583148
Intraocular pressure increased	31.82	17.24	24	17314	6409	42597588
Pain of skin	31.07	17.24	26	17312	8054	42595943
Androgenetic alopecia	30.45	17.24	6	17332	28	42603969
Necrotising scleritis	30.21	17.24	7	17331	78	42603919
Rash pruritic	29.86	17.24	51	17287	33552	42570445
Adrenal suppression	29.44	17.24	12	17326	953	42603044
Cauda equina syndrome	29.26	17.24	12	17326	968	42603029
Eye infection toxoplasmal	29.04	17.24	9	17329	319	42603678
Acute kidney injury	28.09	17.24	68	17270	367269	42236728
Drug effect less than expected	27.50	17.24	18	17320	3839	42600158
Rash macular	27.26	17.24	34	17304	16857	42587140
Chorioretinopathy	27.13	17.24	13	17325	1518	42602479
Therapy non-responder	26.96	17.24	64	17274	53295	42550702
Infective scleritis	26.86	17.24	6	17332	56	42603941
Scratch	26.85	17.24	20	17318	5241	42598756
Hypotony of eye	26.75	17.24	8	17330	251	42603746
Thrombocytopenia	26.58	17.24	23	17315	190256	42413741
Nail pitting	26.48	17.24	9	17329	429	42603568
Melanocytic naevus	26.44	17.24	16	17322	2976	42601021
Brain injury	26.12	17.24	23	17315	7632	42596365
Onycholysis	25.63	17.24	11	17327	994	42603003
Cystoid macular oedema	25.34	17.24	11	17327	1022	42602975
Nephrolithiasis	25.28	17.24	50	17288	36780	42567217
Tinea cruris	24.95	17.24	9	17329	512	42603485
Lichenification	24.90	17.24	9	17329	515	42603482
Renal failure	24.51	17.24	14	17324	143712	42460285
Chondritis	24.34	17.24	7	17331	191	42603806
Choroidal osteoma	24.18	17.24	5	17333	31	42603966
Retinal scar	23.71	17.24	8	17330	373	42603624
Pneumonia lipoid	23.66	17.24	6	17332	100	42603897
Hypotension	23.61	17.24	43	17295	257588	42346409
Scleromalacia	22.75	17.24	5	17333	43	42603954
Dyspnoea	22.64	17.24	98	17240	442523	42161474
Vitreous haemorrhage	22.51	17.24	14	17324	2733	42601264
Interstitial lung disease	21.85	17.24	3	17335	78459	42525538
Confusional state	21.36	17.24	22	17316	167575	42436422
Cardiac arrest	21.13	17.24	9	17329	109311	42494686
Shared psychotic disorder	20.61	17.24	4	17334	17	42603980
Polypoidal choroidal vasculopathy	20.51	17.24	6	17332	174	42603823
Disseminated paracoccidioidomycosis	19.75	17.24	4	17334	22	42603975
Retinal oedema	19.56	17.24	9	17329	959	42603038
Retinal artery embolism	18.93	17.24	4	17334	28	42603969
Retinal deposits	18.68	17.24	4	17334	30	42603967
Neoplasm skin	18.49	17.24	9	17329	1088	42602909
Rapidly progressive osteoarthritis	18.35	17.24	3	17335	3	42603994
Seborrhoeic dermatitis	18.30	17.24	11	17327	2021	42601976
Pancytopenia	17.98	17.24	13	17325	117730	42486267
Human T-cell lymphotropic virus type I infection	17.66	17.24	4	17334	40	42603957
Sebaceous hyperplasia	17.36	17.24	5	17333	137	42603860
Abdominal pain	17.24	17.24	32	17306	190439	42413558

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	811.14	13.41	356	60226	25185	110503532
Adrenal insufficiency	391.74	13.41	260	60322	42130	110486587
Psoriasis	346.55	13.41	405	60177	139588	110389129
Drug ineffective	271.11	13.41	1583	58999	1518957	109009760
Sleep disorder due to a general medical condition	247.94	13.41	215	60367	51897	110476820
Product use in unapproved indication	237.36	13.41	657	59925	446720	110081997
Joint destruction	236.74	13.41	117	60465	10826	110517891
Polyarthritis	234.66	13.41	140	60442	18823	110509894
Obesity	217.93	13.41	289	60293	113062	110415655
Eczema	212.75	13.41	229	60353	72064	110456653
Human antichimeric antibody positive	206.15	13.41	64	60518	1678	110527039
Infusion site reaction	204.50	13.41	125	60457	17557	110511160
Body height below normal	190.85	13.41	63	60519	2021	110526696
Sleep disorder	175.27	13.41	356	60226	198288	110330429
Onychomadesis	163.94	13.41	161	60421	45502	110483215
Rash	155.27	13.41	870	59712	820094	109708623
Dry skin	151.90	13.41	237	60345	107416	110421301
Blepharospasm	151.36	13.41	168	60414	54683	110474034
Back injury	146.25	13.41	154	60428	47245	110481472
Toxicity to various agents	140.94	13.41	44	60538	480511	110048206
Wheelchair user	138.13	13.41	73	60509	7769	110520948
Taste disorder	136.99	13.41	174	60408	65213	110463504
Pruritus	128.72	13.41	644	59938	580916	109947801
Immunodeficiency	123.06	13.41	128	60454	38710	110490007
Therapy non-responder	120.26	13.41	266	60316	157041	110371676
Product quality issue	120.09	13.41	178	60404	77121	110451596
Psoriatic arthropathy	115.18	13.41	300	60282	196461	110332256
Gastroenteritis viral	113.76	13.41	111	60471	31115	110497602
Acute kidney injury	113.01	13.41	109	60473	635321	109893396
Skin exfoliation	108.67	13.41	182	60400	87469	110441248
Impaired quality of life	108.04	13.41	106	60476	29911	110498806
Synovitis	105.32	13.41	360	60222	273732	110254985
Drug tolerance	100.99	13.41	79	60503	16506	110512211
Breast cancer stage III	100.38	13.41	166	60416	78951	110449766
Completed suicide	99.68	13.41	9	60573	242372	110286345
Drug specific antibody	98.16	13.41	42	60540	2786	110525931
Drug ineffective for unapproved indication	92.64	13.41	186	60396	102652	110426065
Facet joint syndrome	88.26	13.41	176	60406	96652	110432065
Peripheral venous disease	86.60	13.41	161	60421	83956	110444761
Ankle arthroplasty	85.63	13.41	37	60545	2514	110526203
Therapeutic product effect decreased	85.32	13.41	311	60271	244005	110284712
Epilepsy	85.24	13.41	177	60405	100032	110428685
Bone density decreased	84.08	13.41	70	60512	15972	110512745
Deposit eye	83.31	13.41	16	60566	43	110528674
Therapeutic product effect incomplete	81.64	13.41	289	60293	223516	110305201
Treatment failure	81.37	13.41	334	60248	276900	110251817
Fibromyalgia	80.67	13.41	241	60341	170668	110358049
Antibody test positive	78.49	13.41	37	60545	3083	110525634
Contraindicated product administered	77.57	13.41	305	60277	247962	110280755
Hypothalamic pituitary adrenal axis suppression	76.28	13.41	24	60558	658	110528059
Liver function test increased	76.01	13.41	157	60425	88391	110440326
Thrombocytopenia	75.60	13.41	49	60533	348836	110179881
Discomfort	74.69	13.41	273	60309	214434	110314283
Intentional product use issue	74.59	13.41	301	60281	247605	110281112
Product dose omission in error	73.60	13.41	77	60505	23435	110505282
Mycotic endophthalmitis	72.78	13.41	21	60561	425	110528292
Skin discomfort	72.13	13.41	31	60551	2079	110526638
Vaginal flatulence	72.11	13.41	57	60525	12087	110516630
Injection site atrophy	70.45	13.41	21	60561	478	110528239
Mobility decreased	70.42	13.41	287	60295	237135	110291582
Wound infection	69.08	13.41	159	60423	96306	110432411
Red blood cell sedimentation rate abnormal	67.48	13.41	75	60507	24434	110504283
Glossodynia	66.34	13.41	269	60313	221735	110306982
Dyspnoea	66.24	13.41	347	60235	1106525	109422192
Nail disorder	66.14	13.41	116	60466	57819	110470898
Cerebrospinal fistula	66.00	13.41	12	60570	21	110528696
Gait inability	65.95	13.41	194	60388	136182	110392535
Macular degeneration	64.37	13.41	69	60513	21590	110507127
Neck pain	63.25	13.41	179	60403	122951	110405766
Hypercholesterolaemia	63.16	13.41	148	60434	90689	110438028
Anti-cyclic citrullinated peptide antibody positive	62.11	13.41	230	60352	181754	110346963
Ocular hypertension	61.95	13.41	29	60553	2379	110526338
Product compounding quality issue	61.76	13.41	12	60570	35	110528682
Off label use	61.53	13.41	1157	59425	1499028	109029689
Pseudomeningocele	61.02	13.41	12	60570	38	110528679
Female genital tract fistula	60.69	13.41	59	60523	16460	110512257
Neutropenia	60.08	13.41	70	60512	374550	110154167
Live birth	59.39	13.41	123	60459	69361	110459356
Death	59.34	13.41	191	60391	698678	109830039
Bursitis	58.29	13.41	180	60402	129738	110398979
Radiculopathy	58.17	13.41	62	60520	19274	110509443
Short stature	58.01	13.41	22	60560	1065	110527652
Eye infection toxoplasmal	57.86	13.41	20	60562	740	110527977
Chronic sinusitis	57.73	13.41	70	60512	25014	110503703
Proctitis	57.63	13.41	58	60524	16869	110511848
Rapidly progressive osteoarthritis	57.43	13.41	11	60571	29	110528688
Skin fissures	55.88	13.41	68	60514	24390	110504327
Type 2 diabetes mellitus	55.54	13.41	218	60364	177014	110351703
Normal newborn	55.18	13.41	64	60518	21832	110506885
Intentional overdose	54.25	13.41	5	60577	132496	110396221
Drug abuse	54.22	13.41	15	60567	177396	110351321
Non-infectious endophthalmitis	53.76	13.41	17	60565	474	110528243
Steroid withdrawal syndrome	53.60	13.41	20	60562	925	110527792
Vaginal discharge	53.13	13.41	57	60525	17851	110510866
Cardiac arrest	52.50	13.41	21	60561	196732	110331985
Folliculitis	52.36	13.41	206	60376	167447	110361270
Night sweats	52.29	13.41	177	60405	133806	110394911
Adrenal suppression	51.74	13.41	23	60559	1673	110527044
Bradycardia	51.72	13.41	11	60571	155506	110373211
Chorioretinopathy	51.01	13.41	25	60557	2270	110526447
Product contamination microbial	50.76	13.41	20	60562	1074	110527643
Renal failure	50.19	13.41	31	60551	226543	110302174
Systemic lupus erythematosus	49.43	13.41	272	60310	254066	110274651
Foot operation	49.27	13.41	37	60545	7276	110521441
Product use issue	48.82	13.41	315	60267	311380	110217337
Necrotising scleritis	48.82	13.41	14	60568	277	110528440
Paraesthesia oral	48.67	13.41	75	60507	33596	110495121
Hand deformity	47.48	13.41	241	60341	218265	110310452
Anaemia	47.47	13.41	148	60434	546938	109981779
Perioral dermatitis	47.35	13.41	17	60565	704	110528013
C-reactive protein increased	47.10	13.41	240	60342	217679	110311038
Pemphigus	46.86	13.41	237	60345	214333	110314384
Depressed level of consciousness	46.60	13.41	4	60578	112274	110416443
Malignant neoplasm progression	45.97	13.41	19	60563	174548	110354169
Maternal exposure during pregnancy	45.85	13.41	267	60315	254616	110274101
Rhabdomyolysis	45.60	13.41	6	60576	120395	110408322
Lip dry	45.20	13.41	139	60443	99944	110428773
Rhegmatogenous retinal detachment	45.15	13.41	13	60569	261	110528456
Pancytopenia	44.62	13.41	30	60552	209583	110319134
Transmission of an infectious agent via product	44.17	13.41	12	60570	193	110528524
Cardio-respiratory arrest	43.33	13.41	6	60576	115830	110412887
Dermatitis	43.07	13.41	64	60518	27773	110500944
Cough	42.84	13.41	121	60461	461520	110067197
Electrocardiogram QT prolonged	42.32	13.41	5	60577	108955	110419762
Arthropathy	42.25	13.41	286	60296	287236	110241481
Coma	42.04	13.41	7	60575	117862	110410855
Bone density increased	42.03	13.41	17	60565	978	110527739
Nightmare	42.03	13.41	76	60506	38787	110489930
Product dose omission issue	41.99	13.41	311	60271	321471	110207246
Eye pruritus	41.87	13.41	69	60513	32706	110496011
Skin atrophy	41.55	13.41	32	60550	6532	110522185
Gastrooesophageal reflux disease	40.85	13.41	201	60381	179775	110348942
Drug intolerance	40.73	13.41	370	60212	406142	110122575
Hypocalcaemia	40.62	13.41	102	60480	65264	110463453
Procedural pain	40.32	13.41	71	60511	35494	110493223
Dry mouth	40.30	13.41	216	60366	199732	110328985
Muscle injury	39.98	13.41	168	60414	140639	110388078
Dehydration	39.87	13.41	57	60525	279454	110249263
Cardiac failure	39.74	13.41	27	60555	187599	110341118
Hypoglycaemia	39.04	13.41	8	60574	116096	110412621
Hyponatraemia	38.99	13.41	37	60545	217616	110311101
Hyperkalaemia	38.75	13.41	13	60569	135783	110392934
Urticaria	38.16	13.41	302	60280	318555	110210162
Hypotony of eye	38.11	13.41	13	60569	462	110528255
Palpitations	37.80	13.41	20	60562	159192	110369525
Renal impairment	37.46	13.41	29	60553	188416	110340301
Febrile neutropenia	37.40	13.41	73	60509	316694	110212023
Retinal artery occlusion	36.68	13.41	25	60557	4224	110524493
Skin irritation	36.68	13.41	45	60537	16274	110512443
Irritable bowel syndrome	36.28	13.41	182	60400	164033	110364684
Duodenal ulcer perforation	35.83	13.41	192	60390	177508	110351209
Seizure	35.79	13.41	41	60541	221144	110307573
Somnolence	35.59	13.41	68	60514	297381	110231336
Overdose	35.03	13.41	46	60536	233748	110294969
Quality of life decreased	35.01	13.41	41	60541	14128	110514589
Scratch	34.50	13.41	39	60543	12940	110515777
Lactic acidosis	34.26	13.41	5	60577	92806	110435911
Blood creatinine increased	34.05	13.41	30	60552	182859	110345858
Rheumatic fever	33.82	13.41	145	60437	122434	110406283
Drug interaction	33.76	13.41	150	60432	500033	110028684
Rebound effect	33.56	13.41	41	60541	14765	110513952
Endophthalmitis	33.42	13.41	31	60551	8156	110520561
Secondary adrenocortical insufficiency	33.41	13.41	24	60558	4410	110524307
Metabolic acidosis	33.28	13.41	7	60575	99737	110428980
Intraocular pressure increased	32.94	13.41	35	60547	10841	110517876
Fall	32.81	13.41	195	60387	603287	109925430
Osteoarthritis	32.63	13.41	191	60391	182432	110346285
Hepatic function abnormal	32.53	13.41	5	60577	89290	110439427
Haemoglobin decreased	32.33	13.41	54	60528	248673	110280044
Shared psychotic disorder	31.97	13.41	7	60575	42	110528675
Eye irritation	30.70	13.41	61	60521	33391	110495326
Nodule	30.55	13.41	60	60522	32571	110496146
Foot deformity	30.49	13.41	76	60506	48404	110480313
Pulmonary embolism	30.32	13.41	44	60538	214430	110314287
Mediastinal abscess	29.84	13.41	8	60574	122	110528595
Myocardial infarction	29.59	13.41	37	60545	192046	110336671
Interstitial lung disease	29.57	13.41	20	60562	139314	110389403
Back pain	28.97	13.41	105	60477	370891	110157826
Myelosuppression	28.77	13.41	8	60574	94332	110434385
Respiratory failure	28.69	13.41	46	60536	215286	110313431
Skin plaque	28.63	13.41	35	60547	12610	110516107
Chest pain	28.43	13.41	108	60474	376267	110152450
Choroiditis	28.34	13.41	15	60567	1600	110527117
Blister	28.09	13.41	217	60365	227159	110301558
Tremor	28.09	13.41	42	60540	202190	110326527
Skin swelling	28.08	13.41	28	60554	8052	110520665
Limb discomfort	27.77	13.41	66	60516	40788	110487929
Oedema peripheral	27.71	13.41	90	60492	328570	110200147
Scleromalacia	27.44	13.41	7	60575	87	110528630
Blood pressure systolic increased	27.33	13.41	6	60576	82985	110445732
Cauda equina syndrome	27.12	13.41	16	60566	2106	110526611
Neurodermatitis	27.11	13.41	18	60564	2914	110525803
Joint range of motion decreased	26.88	13.41	135	60447	121697	110407020
Plastic surgery	26.74	13.41	7	60575	97	110528620
Platelet count decreased	26.43	13.41	54	60528	230389	110298328
Ascites	26.27	13.41	9	60573	92799	110435918
Suicide attempt	26.04	13.41	12	60570	103382	110425335
Dysarthria	25.90	13.41	7	60575	84114	110444603
Disorientation	25.65	13.41	4	60578	70667	110458050
Hypotension	25.52	13.41	175	60407	523674	110005043
Chest discomfort	25.23	13.41	35	60547	173813	110354904
Multiple organ dysfunction syndrome	24.67	13.41	28	60554	151682	110377035
Human anti-human antibody test	24.42	13.41	9	60573	402	110528315
Helicobacter infection	24.40	13.41	177	60405	181700	110347017
Injection site pain	24.36	13.41	174	60408	177748	110350969
Agitation	24.29	13.41	16	60566	113035	110415682
Heart rate increased	23.99	13.41	26	60556	143808	110384909
Lipoatrophy	23.95	13.41	10	60572	624	110528093
Musculoskeletal pain	23.91	13.41	177	60405	182846	110345871
Cerebrovascular accident	23.89	13.41	39	60543	181245	110347472
Angina pectoris	23.84	13.41	3	60579	62292	110466425
Haemoptysis	23.82	13.41	5	60577	71349	110457368
Alanine aminotransferase increased	23.78	13.41	40	60542	183733	110344984
Rebound eczema	23.76	13.41	14	60568	1838	110526879
International normalised ratio increased	23.57	13.41	9	60573	86763	110441954
Oxygen saturation decreased	23.39	13.41	31	60551	156951	110371766
Retinal scar	23.08	13.41	9	60573	470	110528247
Glaucoma	23.04	13.41	43	60539	22474	110506243
Arrhythmia	22.97	13.41	5	60577	69570	110459147
Injury	22.91	13.41	171	60411	177094	110351623
Pyloric abscess	22.80	13.41	4	60578	5	110528712
Birdshot chorioretinopathy	22.79	13.41	6	60576	85	110528632
Septic shock	22.70	13.41	156	60426	157372	110371345
Urinary tract infection	22.51	13.41	97	60485	326185	110202532
Arthritis	22.42	13.41	163	60419	167423	110361294
Gastrointestinal haemorrhage	22.38	13.41	35	60547	165483	110363234
Drug hypersensitivity	22.30	13.41	361	60221	453729	110074988
Dysphagia	22.21	13.41	31	60551	153569	110375148
Oral candidiasis	21.93	13.41	64	60518	44696	110484021
Heart rate decreased	21.79	13.41	9	60573	82747	110445970
Therapeutic response shortened	21.43	13.41	49	60533	29534	110499183
Condition aggravated	21.33	13.41	540	60042	734296	109794421
Skin haemorrhage	21.27	13.41	44	60538	24783	110503934
Papule	21.27	13.41	27	60555	10106	110518611
Cushingoid	21.17	13.41	29	60553	11683	110517034
Swelling	21.11	13.41	289	60293	350752	110177965
Soft tissue atrophy	21.06	13.41	5	60577	45	110528672
Infective scleritis	21.00	13.41	6	60576	117	110528600
Myalgia	20.81	13.41	58	60524	222323	110306394
Wound	20.77	13.41	208	60374	234229	110294488
Full blood count abnormal	20.74	13.41	3	60579	56049	110472668
Lung disorder	20.68	13.41	169	60413	179878	110348839
Acute myocardial infarction	20.67	13.41	10	60572	83767	110444950
Rash macular	20.60	13.41	57	60525	38629	110490088
Tachycardia	20.56	13.41	60	60522	226585	110302132
Deep vein thrombosis	20.46	13.41	28	60554	139859	110388858
Syncope	20.34	13.41	51	60531	202485	110326232
Haematuria	20.34	13.41	10	60572	82995	110445722
Rheumatoid arthritis	20.24	13.41	252	60330	299361	110229356
Epistaxis	20.20	13.41	25	60557	130347	110398370
Impaired healing	20.15	13.41	180	60402	196537	110332180
Cataract subcapsular	20.14	13.41	11	60571	1250	110527467
Anxiety	20.08	13.41	109	60473	344969	110183748
Dermatitis contact	20.05	13.41	31	60551	13922	110514795
Visual acuity reduced	19.77	13.41	50	60532	32123	110496594
Dyspepsia	19.70	13.41	175	60407	190790	110337927
Erythema	19.63	13.41	245	60337	291202	110237515
Eye infection syphilitic	19.42	13.41	4	60578	17	110528700
Abdominal discomfort	19.29	13.41	313	60269	393545	110135172
Therapeutic response decreased	19.26	13.41	104	60478	96395	110432322
Retinal artery embolism	19.23	13.41	6	60576	160	110528557
White blood cell count decreased	19.20	13.41	63	60519	229327	110299390
Blood creatine phosphokinase increased	19.16	13.41	8	60574	73069	110455648
Rash pruritic	19.11	13.41	105	60477	97964	110430753
Pneumonia	19.04	13.41	352	60230	876362	109652355
Skin weeping	18.95	13.41	16	60566	3719	110524998
Mucosal inflammation	18.84	13.41	15	60567	96126	110432591
Necrotising fasciitis	18.81	13.41	22	60560	7569	110521148
Onychomycosis	18.79	13.41	55	60527	38476	110490241
Aspartate aminotransferase increased	18.74	13.41	37	60545	159899	110368818
Dystrophic calcification	18.65	13.41	6	60576	177	110528540
Hypomagnesaemia	18.63	13.41	5	60577	60365	110468352
Vitreal cells	18.62	13.41	6	60576	178	110528539
Frequent bowel movements	18.58	13.41	83	60499	71307	110457410
Muscular weakness	18.55	13.41	213	60369	248255	110280462
Cystoid macular oedema	18.49	13.41	14	60568	2786	110525931
Hallucination	18.44	13.41	17	60565	101415	110427302
Muscle spasms	18.38	13.41	233	60349	277924	110250793
Inflammation	18.37	13.41	174	60408	193064	110335653
Blood pressure fluctuation	18.35	13.41	9	60573	74815	110453902
Product label confusion	18.05	13.41	39	60543	22638	110506079
Pneumonia lipoid	18.01	13.41	6	60576	198	110528519
Atrial fibrillation	17.91	13.41	65	60517	229577	110299140
Skin odour abnormal	17.84	13.41	13	60569	2441	110526276
Orthostatic hypotension	17.78	13.41	7	60575	66242	110462475
Retinal oedema	17.54	13.41	11	60571	1616	110527101
Disseminated paracoccidioidomycosis	17.50	13.41	4	60578	30	110528687
Bone marrow failure	17.46	13.41	5	60577	57843	110470874
Shock	17.39	13.41	4	60578	53584	110475133
Angioedema	17.34	13.41	17	60565	98483	110430234
Melaena	17.28	13.41	8	60574	68749	110459968
Exposure via skin contact	17.23	13.41	28	60554	13119	110515598
Pulmonary fibrosis	17.11	13.41	105	60477	101937	110426780
Neoplasm progression	17.05	13.41	7	60575	64588	110464129
Coronary artery disease	17.02	13.41	9	60573	71681	110457036
Dry eye	16.95	13.41	68	60514	55725	110472992
Polypoidal choroidal vasculopathy	16.89	13.41	6	60576	241	110528476
Blood cholesterol increased	16.88	13.41	165	60417	184620	110344097
Blood pressure decreased	16.87	13.41	23	60559	115068	110413649
Osteonecrosis of jaw	16.80	13.41	3	60579	48014	110480703
Unresponsive to stimuli	16.70	13.41	7	60575	63783	110464934
Retinal ischaemia	16.68	13.41	9	60573	998	110527719
Memory impairment	16.61	13.41	173	60409	196771	110331946
Chondritis	16.61	13.41	6	60576	253	110528464
Neuropathy peripheral	16.59	13.41	47	60535	179230	110349487
Cholelithiasis	16.54	13.41	7	60575	63415	110465302
Tractional retinal detachment	16.29	13.41	5	60577	126	110528591
Bursitis infective	15.96	13.41	10	60572	1466	110527251
Respiratory arrest	15.91	13.41	6	60576	58293	110470424
Colitis ulcerative	15.86	13.41	84	60498	77279	110451438
Speech disorder	15.73	13.41	7	60575	61562	110467155
Liver injury	15.59	13.41	138	60444	150275	110378442
Pain of skin	15.43	13.41	34	60548	19995	110508722
Subcutaneous drug absorption impaired	15.43	13.41	20	60562	7639	110521078
Loss of personal independence in daily activities	15.22	13.41	137	60445	149883	110378834
Macule	15.04	13.41	14	60568	3699	110525018
Prescribed underdose	14.93	13.41	73	60509	65101	110463616
Wheezing	14.87	13.41	209	60373	255021	110273696
Stomatitis	14.84	13.41	219	60363	270023	110258694
Aggression	14.71	13.41	7	60575	59203	110469514
Red blood cell sedimentation rate increased	14.70	13.41	83	60499	78219	110450498
Corneal striae	14.69	13.41	4	60578	65	110528652
Drug effect less than expected	14.57	13.41	19	60563	7301	110521416
Skin burning sensation	14.55	13.41	35	60547	21790	110506927
Injection site plaque	14.52	13.41	5	60577	183	110528534
Orbital infection	14.49	13.41	5	60577	184	110528533
Product prescribing error	14.49	13.41	5	60577	51326	110477391
Cognitive disorder	14.39	13.41	16	60566	87495	110441222
Ill-defined disorder	14.29	13.41	140	60442	156713	110372004
Vertigo	14.16	13.41	16	60566	86854	110441863
Neutrophil count decreased	14.15	13.41	28	60554	120913	110407804
Blood potassium decreased	14.06	13.41	6	60576	54108	110474609
Multiple sclerosis relapse	14.00	13.41	5	60577	50235	110478482
Pustular psoriasis	13.94	13.41	26	60556	13579	110515138
Upper gastrointestinal haemorrhage	13.93	13.41	5	60577	50091	110478626
Ventricular tachycardia	13.90	13.41	5	60577	50004	110478713
Pulmonary oedema	13.88	13.41	21	60561	100638	110428079
Infectious crystalline keratopathy	13.77	13.41	4	60578	83	110528634
Acute respiratory distress syndrome	13.66	13.41	6	60576	53192	110475525
Autoimmune lung disease	13.60	13.41	5	60577	222	110528495
Medication error	13.57	13.41	23	60559	105343	110423374
Delirium	13.55	13.41	34	60548	134991	110393726
Peripheral swelling	13.55	13.41	303	60279	403731	110124986
Chills	13.54	13.41	56	60526	190524	110338193
Feeling abnormal	13.54	13.41	52	60530	180659	110348058
Skin discolouration	13.51	13.41	58	60524	48988	110479729
Macular fibrosis	13.49	13.41	7	60575	717	110528000
Lethargy	13.41	13.41	19	60563	93557	110435160

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AC01	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Corticosteroids for local oral treatment
ATC	C05AA12	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids
ATC	D07AB09	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB03	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
ATC	D07CB01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, moderately potent, combinations with antibiotics
ATC	D07XB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, moderately potent, other combinations
ATC	H02AB08	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids
ATC	R01AD11	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03BA06	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
ATC	S01BA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
ATC	S02CA04	SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
CHEBI has role	CHEBI:35472	anti-inflammatory drug
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:50748	antipsoriatic
CHEBI has role	CHEBI:50857	anti-allergic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:77715	nasal decongestant

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D07AB Corticosteroids, moderately potent (group II) 12 drugs

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S01BA Corticosteroids, plain 15 drugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Lichen planus	indication	4776004	DOID:9201
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377
Severe adrenal insufficiency	indication	24867002
Sarcoidosis	indication	31541009	DOID:11335
Idiopathic thrombocytopenic purpura	indication	32273002	DOID:8924
Psoriasis with arthropathy	indication	33339001
Keloid scar	indication	33659008
Crohn's disease	indication	34000006
Tendinitis	indication	34840004	DOID:971
Erythema multiforme	indication	36715001
Contact dermatitis	indication	40275004	DOID:2773
Angioedema	indication	41291007	DOID:1558
Miliary tuberculosis	indication	47604008	DOID:9861
Humoral hypercalcemia of malignancy	indication	47709007
Articular gout	indication	48440001	DOID:13189
Candidiasis of skin	indication	49883006
Seborrheic dermatitis	indication	50563003	DOID:8741
Edema of larynx	indication	51599000
Nephrotic syndrome	indication	52254009	DOID:1184
Lichen simplex chronicus	indication	53891004
Systemic lupus erythematosus	indication	55464009	DOID:9074
Necrobiosis lipoidica diabeticorum	indication	56391002
Allergic rhinitis	indication	61582004
Löffler's syndrome	indication	64936001	DOID:9503
Pemphigus	indication	65172003	DOID:9182
Granuloma annulare	indication	65508009	DOID:3777
Tenosynovitis	indication	67801009	DOID:970
Alopecia areata	indication	68225006	DOID:986
Rheumatoid arthritis	indication	69896004	DOID:7148
Transfusion reaction due to serum protein reaction	indication	72284000
Epicondylitis	indication	73583000	DOID:14087
Acquired thrombocytopenia	indication	74576004	DOID:11126
Sympathetic uveitis	indication	75315001	DOID:12029
Thyroiditis	indication	82119001	DOID:7166
Bursitis	indication	84017003	DOID:2965
Autoimmune disease	indication	85828009
Congenital hypoplastic anemia	indication	88854002	DOID:1339
Pruritus ani	indication	90446007
Acute lymphoid leukemia	indication	91857003	DOID:9952
Disorder of skin	indication	95320005	DOID:37
Subacute bursitis	indication	109298000
Dermatitis herpetiformis	indication	111196000	DOID:8505
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Mycosis fungoides	indication	118618005
Uveitis	indication	128473001	DOID:13141
Aspiration pneumonitis	indication	155597006
Asthma	indication	195967001	DOID:2841
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Transplanted organ rejection	indication	213148006
Congenital adrenal hyperplasia	indication	237751000
Scalp psoriasis	indication	238608008
Adrenogenital disorder	indication	267395000	DOID:0050811
Pruritus of genital organs	indication	267802000
Eruption of skin	indication	271807003	DOID:0050486
Follicular non-Hodgkin's lymphoma	indication	308121000
Disorder of eye	indication	371405004	DOID:5614
Primary adrenocortical insufficiency	indication	373662000
Adrenal cortical hypofunction	indication	386584007	DOID:10493
Erythroderma	indication	399992009
Primary cutaneous T-cell lymphoma	indication	400122007
Asthma management	indication	406162001
Juvenile rheumatoid arthritis	indication	410795001
Autoimmune hemolytic anemia	indication	413603009	DOID:718
Giant cell arteritis	indication	414341000	DOID:13375
Synovitis	indication	416209007	DOID:2703
Aphthous ulcer of mouth	indication	426965005	DOID:9663
Post traumatic osteoarthritis	indication	699262001
Cystic Aponeurosis Tumor	indication
Erythroblastic Anemia	indication
Diagnostic Test for Cushing's Syndrome	indication
Chronic Non-Allergic Rhinitis	indication
Transfusion Reaction Urticaria	indication
Severe Ocular Inflammation	indication
Gingival Disorders	indication
Vitrectomy Adjunct to Enhance Visualization	indication
Allergic Rhinitis Prevention	indication
Systemic Dermatomyositis	indication
Synovitis due to Osteoarthritis	indication
Pericarditis	off-label use	3238004	DOID:1787
Chronic obstructive lung disease	off-label use	13645005	DOID:3083
West syndrome	off-label use	28055006
Vasculitis	off-label use	31996006	DOID:865
Bronchitis	off-label use	32398004	DOID:6132
Eczema	off-label use	43116000
Respiratory distress syndrome in the newborn	off-label use	46775006
Nasal polyp	off-label use	52756005
Rheumatic fever	off-label use	58718002	DOID:1586
Pseudogout	off-label use	60782007
Polymyalgia rheumatica	off-label use	65323003	DOID:853
Chronic hepatitis	off-label use	76783007	DOID:2237
Pemphigoid	off-label use	86142006
Hepatic necrosis	off-label use	87248009
Multiple myeloma	off-label use	109989006	DOID:9538
Polyarteritis nodosa	off-label use	155441006	DOID:9810
Severe chronic obstructive pulmonary disease	off-label use	313299006
Celiac disease	off-label use	396331005	DOID:10608
Carditis	off-label use	399617002
Neonatal Bronchopulmonary Dysplasia	off-label use
Hypercalcemia associated with Sarcoidosis	off-label use
Infection by Strongyloides	contraindication	1214006	DOID:10955
Mycosis	contraindication	3218000	DOID:1564
Ocular hypertension	contraindication	4210003	DOID:9282
Gastritis	contraindication	4556007	DOID:4029
Inactive tuberculosis	contraindication	11999007
Epistaxis	contraindication	12441001
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Measles	contraindication	14189004	DOID:8622
Disease caused by parasite	contraindication	17322007
Cirrhosis of liver	contraindication	19943007	DOID:5082
Arginase deficiency	contraindication	23501004	DOID:9278
Glaucoma	contraindication	23986001	DOID:1686
Acute tuberculosis	contraindication	25629007
Fungal infection of eye	contraindication	31194008
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Infectious disease	contraindication	40733004
Hypothyroidism	contraindication	40930008	DOID:1459
Herpes zoster keratoconjunctivitis	contraindication	42448002
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Tuberculosis of eye	contraindication	49107007
Cerebral malaria	contraindication	53622003	DOID:14069
Tuberculosis	contraindication	56717001
Congenital hyperammonemia, type I	contraindication	62522004
Osteoporosis	contraindication	64859006	DOID:11476
Psychotic disorder	contraindication	69322001
Diabetes mellitus	contraindication	73211009	DOID:9351
Hypopituitarism	contraindication	74728003	DOID:9406
Candidiasis of mouth	contraindication	79740000	DOID:14262
Perforation of nasal septum	contraindication	80142000
Hyperglycemia	contraindication	80394007	DOID:4195
Ornithine Carbamyltransferase Deficiency	contraindication	80908008	DOID:9271
Open-angle glaucoma	contraindication	84494001	DOID:1067
Bacterial infectious disease	contraindication	87628006
Muscle atrophy	contraindication	88092000	DOID:767
Herpes simplex	contraindication	88594005	DOID:8566
Operation on nose	contraindication	88733004
Bilateral cataracts	contraindication	95722004
Seizure disorder	contraindication	128613002
Disorder of muscle	contraindication	129565002	DOID:423
Ophthalmic herpes simplex	contraindication	186542001
Anastomosis of intestine	contraindication	235407009
Disease of liver	contraindication	235856003	DOID:409
Telangiectasia disorder	contraindication	247479008
Edema	contraindication	267038008
Pathological fracture	contraindication	268029009
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral trauma	contraindication	275382005
Oral infection	contraindication	275393007
Varicella-zoster virus infection	contraindication	309465005
Viral eye infection	contraindication	312132001
Osteopenia	contraindication	312894000
Skin irritation	contraindication	367466007
Herpes zoster keratitis	contraindication	397573005
Avascular necrosis of bone	contraindication	397758007	DOID:10159
Citrullinemia	contraindication	398680004	DOID:9273
Atrophoderma	contraindication	399979006
Traumatic rupture of tendon	contraindication	415749005
Exposure to varicella	contraindication	444453009
Arginosuccinate Lyase Deficiency	contraindication
Oropharyngeal Candidiasis	contraindication
Nasal Candidiasis	contraindication
Periodontal Infections	contraindication
Nasal Trauma	contraindication
Untreated Fungal Infection	contraindication
Nasal Septal Ulcers	contraindication
Uncontrolled Bacterial Infections	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.2	acidic
pKa2	11.84	acidic
pKa3	13.18	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	7.59	DRUG MATRIX	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN				WOMBAT-PK
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN				WOMBAT-PK

External reference:

ID	Source
4017599	VUID
N0000145980	NUI
D00385	KEGG_DRUG
4017599	VANDF
C0040864	UMLSCUI
CHEBI:9667	CHEBI
CHEMBL1451	ChEMBL_ID
D014221	MESH_DESCRIPTOR_UI
DB00620	DRUGBANK_ID
31307	PUBCHEM_CID
2870	IUPHAR_LIGAND_ID
755	INN_ID
1ZK20VI6TY	UNII
10759	RXNORM
4582	MMSL
5613	MMSL
d00620	MMSL
002188	NDDF
116594009	SNOMEDCT_US
6028009	SNOMEDCT_US
1ZK20VI6TY	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Naltrexone	HUMAN PRESCRIPTION DRUG LABEL	2	69364-3143	IMPLANT	6.50 mg	SUBCUTANEOUS	Unapproved drug other	25 sections

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triamcinolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: