betamethasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 348 378-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone
  • betadexamethasone
  • betametasone
  • betamethazone
  • bethamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P
0.40 mg P
0.40 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.06 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 4.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.36 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 0.72 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.976 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 5.152 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 27.416 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 4.416 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 42.180 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 53.280 % Moderate 0.65
herg hERG pIC50 4.353 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 2.056 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 10.568 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 29.420 % Moderate 0.65
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 15.276 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 11.220 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 8.472 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 38.410 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 18.578 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 40.890 % Moderate 0.65
rat-kpuu-brain Rat brain Kpuu 0.067 % High 1
rh-clint Rat hepatocyte intrinsic clearance 15.959 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 74.520 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 26.010 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 422.669 uM Moderate 0.65

Approvals:

DateAgencyCompanyOrphan
April 17, 1961 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1729.05 12.46 660 42154 38102 90547531
Premature baby 1063.90 12.46 412 42402 24665 90560968
Maternal exposure during pregnancy 903.39 12.46 974 41840 359089 90226544
Low birth weight baby 669.49 12.46 227 42587 9240 90576393
Foetal exposure during pregnancy 589.32 12.46 322 42492 42653 90542980
Exposure during pregnancy 487.43 12.46 581 42233 237829 90347804
Normal labour 292.22 12.46 66 42748 551 90585082
Macular degeneration 271.99 12.46 188 42626 37782 90547851
Delivery 257.70 12.46 74 42740 1719 90583914
Neonatal respiratory distress syndrome 233.58 12.46 78 42736 3023 90582610
Product use in unapproved indication 211.99 12.46 481 42333 335755 90249878
Infusion site reaction 207.87 12.46 123 42691 18916 90566717
Foetal growth restriction 206.88 12.46 97 42717 9283 90576350
Blepharospasm 168.79 12.46 167 42647 55278 90530355
Premature labour 163.49 12.46 93 42721 13283 90572350
Computerised tomogram thorax abnormal 151.26 12.46 51 42763 2036 90583597
Live birth 150.13 12.46 186 42628 78921 90506712
Back injury 142.97 12.46 141 42673 46481 90539152
Pre-eclampsia 132.84 12.46 76 42738 10972 90574661
Patent ductus arteriosus 122.05 12.46 54 42760 4515 90581118
Epilepsy 115.63 12.46 167 42647 82039 90503594
Computerised tomogram thorax 104.60 12.46 28 42786 497 90585136
Taste disorder 103.03 12.46 136 42678 61410 90524223
Steroid withdrawal syndrome 93.14 12.46 27 42787 649 90584984
Breast cancer stage III 92.71 12.46 153 42661 84294 90501339
Normal newborn 91.55 12.46 81 42733 23281 90562352
Hypercholesterolaemia 85.24 12.46 163 42651 100729 90484904
Fall 84.01 12.46 63 42751 481747 90103886
Blood pressure inadequately controlled 83.47 12.46 46 42768 6178 90579455
Therapeutic product effect incomplete 83.03 12.46 240 42574 193656 90391977
Premature rupture of membranes 79.87 12.46 43 42771 5515 90580118
Onychomadesis 79.08 12.46 103 42711 45895 90539738
Fatigue 78.10 12.46 282 42532 1153741 89431892
Exercise tolerance decreased 77.77 12.46 47 42767 7504 90578129
Skin exfoliation 77.18 12.46 125 42689 67788 90517845
Diabetes mellitus inadequate control 69.68 12.46 63 42751 18621 90567012
Ductus arteriosus premature closure 67.70 12.46 19 42795 405 90585228
Peripheral venous disease 66.52 12.46 132 42682 83789 90501844
Preterm premature rupture of membranes 66.11 12.46 26 42788 1615 90584018
Atelectasis 66.02 12.46 69 42745 24340 90561293
Gastrooesophageal reflux disease 63.73 12.46 198 42616 166139 90419494
Foetal heart rate deceleration abnormality 62.98 12.46 20 42794 659 90584974
Respiratory disorder neonatal 62.85 12.46 24 42790 1377 90584256
Overlap syndrome 62.77 12.46 43 42771 8505 90577128
Caesarean section 62.23 12.46 59 42755 18518 90567115
Product quality issue 61.94 12.46 124 42690 79201 90506432
Death 61.69 12.46 75 42739 456476 90129157
Drug ineffective 60.89 12.46 953 41861 1383345 89202288
Selective eating disorder 60.48 12.46 26 42788 2027 90583606
Psoriasis 59.51 12.46 179 42635 147575 90438058
Gestational diabetes 58.90 12.46 45 42769 10537 90575096
Multiple drug therapy 58.06 12.46 38 42776 6971 90578662
Facet joint syndrome 57.67 12.46 137 42677 98252 90487381
Liver function test increased 56.20 12.46 124 42690 84731 90500902
Diarrhoea 56.08 12.46 241 42573 938949 89646684
Oligohydramnios 54.72 12.46 37 42777 7164 90578469
Chronic sinusitis 51.74 12.46 60 42754 23742 90561891
Neutropenia 51.29 12.46 21 42793 224883 90360750
Bradycardia neonatal 50.02 12.46 19 42795 1074 90584559
Neonatal hypocalcaemia 48.52 12.46 9 42805 23 90585610
Atrial septal defect 48.01 12.46 36 42778 8198 90577435
Acute kidney injury 47.22 12.46 49 42765 320338 90265295
Toxicity to various agents 47.14 12.46 40 42774 287806 90297827
Analgesic therapy 47.04 12.46 16 42798 656 90584977
Pain 46.21 12.46 279 42535 996062 89589571
Antacid therapy 45.24 12.46 16 42798 738 90584895
Appendicolith 45.09 12.46 16 42798 745 90584888
Foetal hypokinesia 44.17 12.46 15 42799 612 90585021
Drug therapy 44.14 12.46 16 42798 793 90584840
Anticoagulant therapy 43.98 12.46 16 42798 801 90584832
Neonatal gastrointestinal haemorrhage 43.25 12.46 8 42806 20 90585613
Vomiting 41.27 12.46 212 42602 788081 89797552
Seizure 40.47 12.46 11 42803 152618 90433015
Urinary tract infection 40.41 12.46 51 42763 305581 90280052
Bronchopulmonary dysplasia 40.35 12.46 14 42800 610 90585023
Infantile apnoea 40.24 12.46 17 42797 1270 90584363
Wound infection 40.12 12.46 126 42688 106276 90479357
Paraesthesia oral 39.73 12.46 61 42753 31598 90554035
Neonatal gastrointestinal disorder 39.24 12.46 9 42805 81 90585552
Weight gain poor 38.38 12.46 16 42798 1156 90584477
Medication error 38.35 12.46 107 42707 84545 90501088
Bursitis 38.33 12.46 143 42671 131511 90454122
Rectal cancer metastatic 37.38 12.46 11 42803 279 90585354
Hypotension 37.38 12.46 60 42754 325337 90260296
Neonatal respiratory depression 36.92 12.46 10 42804 186 90585447
Incorrect route of product administration 35.82 12.46 76 42738 50550 90535083
Foetal distress syndrome 35.65 12.46 17 42797 1688 90583945
Hypoxia 35.28 12.46 94 42720 72305 90513328
Neck pain 35.04 12.46 126 42688 113837 90471796
Polyhydramnios 34.91 12.46 19 42795 2489 90583144
Dry mouth 34.44 12.46 175 42639 183884 90401749
Foetal non-stress test abnormal 34.42 12.46 7 42807 33 90585600
Bone erosion 33.43 12.46 76 42738 52945 90532688
Nail disorder 33.26 12.46 81 42733 58986 90526647
Sepsis neonatal 32.98 12.46 12 42802 601 90585032
White blood cell count decreased 32.93 12.46 19 42795 167090 90418543
Placental insufficiency 32.90 12.46 16 42798 1659 90583974
Multiple epiphyseal dysplasia 32.57 12.46 8 42806 99 90585534
Amniotic cavity infection 32.53 12.46 15 42799 1381 90584252
Cervical incompetence 32.33 12.46 12 42802 636 90584997
Breast cancer stage II 32.21 12.46 59 42755 35275 90550358
Night sweats 31.93 12.46 133 42681 128633 90457000
Obesity 31.88 12.46 116 42698 105391 90480242
Skeletal dysplasia 31.86 12.46 8 42806 109 90585524
Neonatal cholestasis 31.71 12.46 7 42807 52 90585581
Cardiac failure congestive 30.48 12.46 5 42809 98689 90486944
Catarrh 30.28 12.46 15 42799 1619 90584014
C-reactive protein increased 30.20 12.46 167 42647 181222 90404411
Umbilical erythema 29.59 12.46 7 42807 73 90585560
Procedural pain 29.52 12.46 55 42759 33305 90552328
Decreased appetite 29.48 12.46 86 42728 376454 90209179
Dehydration 29.47 12.46 29 42785 194418 90391215
Hypersensitivity 29.34 12.46 113 42701 454564 90131069
Hydrops foetalis 29.30 12.46 11 42803 602 90585031
Hypotonia neonatal 29.12 12.46 14 42800 1416 90584217
Drug interaction 28.98 12.46 54 42760 276399 90309234
Infection 28.86 12.46 82 42732 362012 90223621
Ophthalmic herpes simplex 28.79 12.46 11 42803 632 90585001
Psoriatic arthropathy 28.42 12.46 195 42619 228140 90357493
Drug abuse 28.23 12.46 3 42811 82344 90503289
HELLP syndrome 28.12 12.46 13 42801 1204 90584429
Radiculopathy 28.07 12.46 39 42775 18466 90567167
Neonatal respiratory failure 27.93 12.46 9 42805 311 90585322
Frequent bowel movements 27.82 12.46 74 42740 56861 90528772
Skin weeping 27.74 12.46 17 42797 2783 90582850
Hepatic cirrhosis 27.71 12.46 79 42735 63174 90522459
Female genital tract fistula 27.62 12.46 38 42776 17830 90567803
Burns second degree 27.56 12.46 15 42799 1965 90583668
Gait inability 26.52 12.46 138 42676 146318 90439315
Foetal exposure during delivery 26.41 12.46 9 42805 371 90585262
Brachydactyly 26.30 12.46 8 42806 228 90585405
Vaginal flatulence 26.04 12.46 31 42783 12607 90573026
Hyperphosphataemia 25.68 12.46 18 42796 3693 90581940
Steroid dependence 25.65 12.46 15 42799 2254 90583379
Foetal anaemia 25.60 12.46 7 42807 135 90585498
Ulcer haemorrhage 25.33 12.46 45 42769 26276 90559357
Social (pragmatic) communication disorder 24.69 12.46 5 42809 23 90585610
Sensory processing disorder 24.51 12.46 5 42809 24 90585609
Lung disorder 24.28 12.46 137 42677 149746 90435887
Neonatal intestinal perforation 24.18 12.46 5 42809 26 90585607
Papule 24.14 12.46 24 42790 7978 90577655
Product dose omission issue 24.02 12.46 65 42749 291622 90294011
Coma 24.01 12.46 3 42811 72629 90513004
Foetal heart rate disorder 24.00 12.46 7 42807 172 90585461
Back pain 23.70 12.46 74 42740 317101 90268532
Cardiac arrest 23.58 12.46 10 42804 104925 90480708
Discomfort 23.45 12.46 60 42754 274275 90311358
Skin infection 23.23 12.46 35 42779 17829 90567804
Joint swelling 23.20 12.46 141 42673 503159 90082474
Blood uric acid increased 23.05 12.46 23 42791 7681 90577952
Proctitis 22.91 12.46 32 42782 15227 90570406
Laryngitis 22.83 12.46 64 42750 50689 90534944
Starvation ketoacidosis 22.42 12.46 7 42807 218 90585415
Myocardial infarction 22.41 12.46 11 42803 105961 90479672
Maternal condition affecting foetus 22.24 12.46 7 42807 224 90585409
Corneal perforation 22.22 12.46 9 42805 604 90585029
Polyglandular disorder 22.15 12.46 7 42807 227 90585406
Heart rate increased 22.00 12.46 13 42801 112889 90472744
Exostosis 21.97 12.46 65 42749 53069 90532564
Depressed level of consciousness 21.79 12.46 4 42810 72780 90512853
White matter lesion 21.69 12.46 14 42800 2507 90583126
Ventricular septal defect 21.68 12.46 19 42795 5388 90580245
Renal failure 21.68 12.46 18 42796 130989 90454644
Intentional overdose 20.99 12.46 9 42805 93825 90491808
Vaginal discharge 20.99 12.46 35 42779 19429 90566204
Rectal haemorrhage 20.93 12.46 86 42728 82658 90502975
Cerebral haemorrhage neonatal 20.86 12.46 6 42808 140 90585493
Acute pulmonary oedema 20.57 12.46 24 42790 9556 90576077
Hypokalaemia 20.51 12.46 19 42795 131097 90454536
Leukopenia 20.48 12.46 11 42803 100699 90484934
Hypotonia 20.28 12.46 26 42788 11400 90574233
Intermittent positive pressure breathing 20.27 12.46 5 42809 63 90585570
Treatment noncompliance 20.18 12.46 62 42752 51665 90533968
Oropharyngeal pain 20.11 12.46 15 42799 115172 90470461
Genital blister 20.00 12.46 6 42808 163 90585470
Meconium abnormal 19.97 12.46 3 42811 0 90585633
Thrombocytopenia 19.95 12.46 43 42771 208682 90376951
Pulmonary valve disease 19.48 12.46 4 42810 20 90585613
Pulmonary valve stenosis congenital 19.37 12.46 6 42808 182 90585451
Cholestasis of pregnancy 19.36 12.46 11 42803 1566 90584067
Type 2 diabetes mellitus 19.34 12.46 163 42651 203081 90382552
Bradycardia foetal 19.29 12.46 8 42806 570 90585063
Sinusitis 19.20 12.46 90 42724 342998 90242635
Blood phosphorus increased 19.00 12.46 16 42798 4302 90581331
Sleep disorder 18.93 12.46 159 42655 197871 90387762
Pulmonary hypoplasia 18.88 12.46 7 42807 370 90585263
Hypopnoea 18.64 12.46 16 42798 4415 90581218
Haemoglobin decreased 18.45 12.46 30 42784 161926 90423707
Hypertension 18.41 12.46 311 42503 457221 90128412
Vulvovaginal ulceration 18.33 12.46 4 42810 28 90585605
Pancytopenia 18.14 12.46 18 42796 120245 90465388
Injection site pain 18.13 12.46 34 42780 173665 90411968
Atrial fibrillation 17.95 12.46 22 42792 133589 90452044
Jaundice neonatal 17.91 12.46 9 42805 1001 90584632
Jarisch-Herxheimer reaction 17.89 12.46 7 42807 429 90585204
Drug tolerance 17.71 12.46 31 42783 17885 90567748
Headache 17.69 12.46 294 42520 862452 89723181
Foetal exposure timing unspecified 17.69 12.46 7 42807 442 90585191
Syncope 17.66 12.46 22 42792 132641 90452992
Depressed mood 17.59 12.46 58 42756 50164 90535469
Wrong technique in product usage process 17.45 12.46 6 42808 71565 90514068
Fluid retention 17.37 12.46 10 42804 88081 90497552
Delayed delivery 17.34 12.46 4 42810 37 90585596
Joint stiffness 17.34 12.46 78 42736 77964 90507669
Aortic stenosis 17.29 12.46 18 42796 6318 90579315
Pneumocephalus 17.26 12.46 6 42808 263 90585370
Intraventricular haemorrhage neonatal 17.21 12.46 6 42808 265 90585368
Blood glucose increased 17.15 12.46 12 42802 95234 90490399
Colitis ulcerative 17.15 12.46 65 42749 60201 90525432
Osteoarthritis 17.07 12.46 154 42660 195576 90390057
Joint range of motion decreased 16.95 12.46 116 42698 135527 90450106
Angiotensin converting enzyme inhibitor foetopathy 16.88 12.46 4 42810 42 90585591
Tremor 16.87 12.46 29 42785 153144 90432489
Chronic hepatitis 16.85 12.46 9 42805 1136 90584497
Dyspnoea 16.84 12.46 304 42510 880651 89704982
Lip dry 16.82 12.46 93 42721 100862 90484771
Myalgia 16.80 12.46 36 42778 175089 90410544
Meningitis chemical 16.75 12.46 6 42808 287 90585346
Illness 16.60 12.46 9 42805 81960 90503673
Alanine aminotransferase increased 16.42 12.46 19 42795 118319 90467314
Anaemia folate deficiency 16.37 12.46 7 42807 539 90585094
Feeling abnormal 16.36 12.46 34 42780 167201 90418432
Breech presentation 15.99 12.46 9 42805 1258 90584375
Sleep disorder due to a general medical condition 15.96 12.46 52 42762 44686 90540947
Loss of consciousness 15.95 12.46 26 42788 140212 90445421
Eczema 15.86 12.46 58 42756 52812 90532821
Perioral dermatitis 15.83 12.46 7 42807 584 90585049
Activated partial thromboplastin time prolonged 15.80 12.46 19 42795 7806 90577827
Pulmonary haemorrhage neonatal 15.76 12.46 4 42810 57 90585576
Skin burning sensation 15.71 12.46 31 42783 19580 90566053
Influenza 15.67 12.46 26 42788 139238 90446395
Off label use 15.52 12.46 652 42162 1101600 89484033
Pustule 15.48 12.46 12 42802 2871 90582762
Blood pressure increased 15.45 12.46 45 42769 197172 90388461
Retroplacental haematoma 15.43 12.46 5 42809 176 90585457
Chest discomfort 15.41 12.46 26 42788 138339 90447294
Oesophageal atresia 15.40 12.46 7 42807 623 90585010
Arthralgia 15.40 12.46 267 42547 778255 89807378
Blood cholesterol increased 15.34 12.46 158 42656 207854 90377779
Foetal growth abnormality 15.33 12.46 4 42810 64 90585569
Anaemia neonatal 15.31 12.46 6 42808 369 90585264
Musculoskeletal stiffness 15.31 12.46 80 42734 296452 90289181
Right ventricular dysfunction 15.28 12.46 11 42803 2353 90583280
Oral candidiasis 15.26 12.46 44 42770 35411 90550222
Intentional product use issue 15.18 12.46 163 42651 216729 90368904
Somatostatin receptor scan abnormal 15.15 12.46 3 42811 12 90585621
Ultrasound uterus abnormal 15.10 12.46 4 42810 68 90585565
Platelet count decreased 15.02 12.46 26 42788 136943 90448690
Neuropathy peripheral 15.02 12.46 26 42788 136944 90448689
Tachycardia foetal 15.01 12.46 5 42809 192 90585441
Hyponatraemia 14.96 12.46 25 42789 133513 90452120
Arrhythmia neonatal 14.94 12.46 4 42810 71 90585562
Gestational hypertension 14.84 12.46 12 42802 3050 90582583
Fine motor delay 14.82 12.46 5 42809 200 90585433
Pneumocystis jirovecii pneumonia 14.77 12.46 32 42782 21584 90564049
Therapy interrupted 14.48 12.46 3 42811 50105 90535528
Hot flush 14.48 12.46 5 42809 59483 90526150
Tracheo-oesophageal fistula 14.46 12.46 7 42807 719 90584914
Blister 14.45 12.46 184 42630 254814 90330819
Breast injury 14.45 12.46 4 42810 81 90585552
Maternal exposure during delivery 14.40 12.46 13 42801 3833 90581800
Poor sucking reflex 14.32 12.46 6 42808 439 90585194
Periventricular leukomalacia 14.23 12.46 5 42809 226 90585407
Impetigo 14.23 12.46 9 42805 1557 90584076
Cardio-respiratory arrest 14.21 12.46 6 42808 63134 90522499
Vitiligo 14.06 12.46 10 42804 2100 90583533
Maternal exposure during breast feeding 14.06 12.46 16 42798 6204 90579429
Right aortic arch 14.01 12.46 5 42809 237 90585396
Sleep disorder therapy 13.81 12.46 6 42808 480 90585153
Red blood cell sedimentation rate increased 13.70 12.46 76 42738 82519 90503114
Skin plaque 13.63 12.46 20 42794 9955 90575678
Shared psychotic disorder 13.62 12.46 3 42811 22 90585611
Chills 13.62 12.46 26 42788 131955 90453678
Hypocholesterolaemia 13.59 12.46 16 42798 6433 90579200
Toxic anterior segment syndrome 13.48 12.46 10 42804 2240 90583393
Adrenal haematoma 13.39 12.46 3 42811 24 90585609
Vaccination site pruritus 13.39 12.46 3 42811 24 90585609
Libido increased 13.34 12.46 9 42805 1735 90583898
Umbilical artery vascular resistance increased 13.29 12.46 3 42811 25 90585608
Neonatal sinus tachycardia 13.29 12.46 3 42811 25 90585608
Small for dates baby 13.26 12.46 14 42800 4993 90580640
Amnesia 13.09 12.46 92 42722 108413 90477220
Overdose 13.08 12.46 35 42779 157674 90427959
Therapeutic product effect delayed 13.03 12.46 12 42802 3629 90582004
Rhabdomyolysis 13.02 12.46 4 42810 51252 90534381
Dermatitis atopic 13.01 12.46 32 42782 23440 90562193
End stage renal disease 12.91 12.46 18 42796 8553 90577080
Femur fracture 12.83 12.46 3 42811 46079 90539554
Disease progression 12.81 12.46 35 42779 156580 90429053
Pericoronitis 12.74 12.46 4 42810 127 90585506
Blood corticotrophin increased 12.74 12.46 4 42810 127 90585506
Treatment failure 12.72 12.46 208 42606 303720 90281913
Urticaria 12.71 12.46 213 42601 312521 90273112
Endocrine disorder 12.61 12.46 7 42807 953 90584680
Scab 12.58 12.46 19 42795 9702 90575931
Dysarthria 12.55 12.46 5 42809 54477 90531156
Umbilical cord prolapse 12.54 12.46 3 42811 33 90585600
Decreased insulin requirement 12.53 12.46 4 42810 134 90585499

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 878.69 19.84 367 23289 22786 42574893
Low birth weight baby 553.06 19.84 208 23448 9747 42587932
Foetal exposure during pregnancy 478.27 19.84 308 23348 47003 42550676
Appendicolith 397.72 19.84 179 23477 13277 42584402
Stress 369.98 19.84 256 23400 43956 42553723
Appendicitis 347.56 19.84 187 23469 20426 42577253
Drug eruption 237.25 19.84 152 23504 22923 42574756
Cardiogenic shock 233.39 19.84 178 23478 35462 42562217
Blood phosphorus increased 189.95 19.84 106 23550 12419 42585260
Ventricular fibrillation 189.64 19.84 147 23509 29976 42567703
Ascites 189.12 19.84 193 23463 56485 42541194
Pain in extremity 180.98 19.84 310 23346 150294 42447385
Pulmonary vasculitis 158.92 19.84 75 23581 6191 42591488
Stomatitis 147.56 19.84 160 23496 50169 42547510
Neuritis 147.23 19.84 71 23585 6149 42591530
Abdominal distension 147.22 19.84 190 23466 71545 42526134
Catarrh 146.76 19.84 70 23586 5916 42591763
Burns second degree 145.55 19.84 70 23586 6026 42591653
Hepatic function abnormal 144.35 19.84 160 23496 51407 42546272
Steroid dependence 136.13 19.84 69 23587 6653 42591026
Eosinophilic granulomatosis with polyangiitis 130.67 19.84 73 23583 8565 42589114
Parosmia 130.16 19.84 70 23586 7621 42590058
Hypopnoea 128.55 19.84 70 23586 7812 42589867
Urticaria 127.39 19.84 180 23476 73856 42523823
Gingival pain 126.36 19.84 71 23585 8423 42589256
Systemic lupus erythematosus 125.48 19.84 73 23583 9251 42588428
Myasthenia gravis 124.46 19.84 89 23567 16048 42581631
Respiratory symptom 123.70 19.84 77 23579 11029 42586650
Neurological symptom 120.80 19.84 73 23583 9918 42587761
Hyponatraemia 117.96 19.84 206 23450 101256 42496423
Pulmonary embolism 115.33 19.84 224 23432 119388 42478291
Total lung capacity abnormal 115.19 19.84 54 23602 4389 42593290
Loss of personal independence in daily activities 115.00 19.84 140 23516 49676 42548003
Hypersensitivity 114.35 19.84 169 23487 72201 42525478
Pulmonary alveolar haemorrhage 110.34 19.84 80 23576 14736 42582943
Eczema 108.06 19.84 113 23543 33973 42563706
Multiple organ dysfunction syndrome 107.61 19.84 193 23463 96842 42500837
Bronchiectasis 107.02 19.84 85 23571 17934 42579745
Rhinitis 106.27 19.84 72 23584 11905 42585774
Epistaxis 102.61 19.84 154 23502 66672 42531007
Blood uric acid increased 102.45 19.84 78 23578 15469 42582210
Toxicity to various agents 100.19 19.84 7 23649 229129 42368550
Cardiac murmur 97.46 19.84 70 23586 12705 42584974
Mite allergy 96.96 19.84 50 23606 4996 42592683
Neonatal respiratory distress syndrome 96.29 19.84 48 23608 4465 42593214
Impaired work ability 96.26 19.84 68 23588 12023 42585656
Alcohol poisoning 95.87 19.84 57 23599 7517 42590162
Patent ductus arteriosus 95.56 19.84 44 23612 3432 42594247
Mycotic allergy 95.53 19.84 49 23607 4842 42592837
Dust allergy 94.36 19.84 50 23606 5282 42592397
Conjunctivitis allergic 92.26 19.84 51 23605 5860 42591819
Antineutrophil cytoplasmic antibody positive 91.88 19.84 46 23610 4319 42593360
Spirometry abnormal 90.34 19.84 48 23608 5098 42592581
Forced expiratory volume decreased 90.31 19.84 55 23601 7575 42590104
Blood cholesterol increased 88.98 19.84 91 23565 26650 42571029
Frequent bowel movements 88.39 19.84 82 23574 21325 42576354
Pulmonary fibrosis 87.34 19.84 90 23566 26591 42571088
Condition aggravated 86.63 19.84 329 23327 260425 42337254
Dry mouth 85.47 19.84 108 23548 39771 42557908
Hyperphosphataemia 85.15 19.84 65 23591 12939 42584740
Drug ineffective 85.09 19.84 618 23038 629579 41968100
Acute kidney injury 81.33 19.84 52 23604 367285 42230394
Muscle spasms 80.26 19.84 159 23497 85885 42511794
Vasculitis 78.93 19.84 72 23584 18322 42579357
Obstructive airways disorder 78.32 19.84 82 23574 24677 42573002
Impaired quality of life 78.08 19.84 64 23592 14113 42583566
Therapeutic product effect incomplete 77.19 19.84 140 23516 70799 42526880
Normochromic normocytic anaemia 74.70 19.84 52 23604 8979 42588700
Atrial septal defect 73.59 19.84 49 23607 7870 42589809
Swollen tongue 72.00 19.84 73 23583 21158 42576521
Iron deficiency 71.79 19.84 55 23601 11006 42586673
Hypothyroidism 70.51 19.84 88 23568 31996 42565683
Sleep disorder due to a general medical condition 68.49 19.84 65 23591 17388 42580291
Colitis ulcerative 67.70 19.84 78 23578 26097 42571582
Thrombosis 65.56 19.84 128 23528 68383 42529296
Incorrect route of product administration 65.52 19.84 74 23582 24231 42573448
Nightmare 65.48 19.84 75 23581 24937 42572742
Sleep disorder therapy 64.89 19.84 43 23613 6851 42590828
Analgesic therapy 64.59 19.84 42 23614 6482 42591197
Diarrhoea 64.30 19.84 98 23558 460751 42136928
Capillaritis 63.75 19.84 29 23627 2199 42595480
Migraine 62.84 19.84 74 23582 25340 42572339
Neuralgia 62.29 19.84 74 23582 25573 42572106
Nodule 61.62 19.84 53 23603 12481 42585198
Somnolence 59.67 19.84 193 23463 140912 42456767
Full blood count abnormal 59.44 19.84 78 23578 29798 42567881
Hypophosphataemia 58.57 19.84 65 23591 20880 42576799
Accidental overdose 57.97 19.84 75 23581 28255 42569424
Fall 56.35 19.84 30 23626 234490 42363189
Sleep disorder 56.25 19.84 98 23558 47997 42549682
Medication error 56.05 19.84 80 23576 33074 42564605
Drug therapy 55.75 19.84 38 23618 6342 42591337
Vertigo 55.33 19.84 81 23575 34266 42563413
Constipation 54.77 19.84 206 23450 162085 42435594
Tinnitus 53.66 19.84 73 23583 28865 42568814
Foetal growth restriction 52.27 19.84 34 23622 5249 42592430
Sepsis 50 19.84 231 23425 199103 42398576
General physical health deterioration 49.39 19.84 190 23466 151056 42446623
Asthenia 48.11 19.84 51 23605 280742 42316937
Abdominal pain 47.97 19.84 221 23435 190250 42407429
Hypotension 47.34 19.84 44 23612 257587 42340092
Arteriosclerosis coronary artery 47.19 19.84 55 23601 18622 42579057
Dysgeusia 47.12 19.84 75 23581 34114 42563565
Drug interaction 46.29 19.84 48 23608 266951 42330728
Haemoptysis 46.28 19.84 88 23568 46079 42551600
Total lung capacity decreased 45.52 19.84 27 23629 3543 42594136
Bacterial infection 45.26 19.84 66 23590 27813 42569866
Drug abuse 43.51 19.84 4 23652 104767 42492912
Product use in unapproved indication 42.78 19.84 209 23447 184247 42413432
Arteriosclerosis 42.19 19.84 51 23605 17938 42579741
Rectal haemorrhage 41.86 19.84 88 23568 49518 42548161
Tubulointerstitial nephritis 41.82 19.84 68 23588 31480 42566199
Dizziness 40.78 19.84 47 23609 249207 42348472
Arthritis 40.71 19.84 79 23577 41986 42555693
Death 39.63 19.84 132 23524 471053 42126626
Palpitations 39.30 19.84 87 23569 50710 42546969
Wheezing 39.24 19.84 91 23565 54690 42542989
Foetal heart rate deceleration abnormality 39.17 19.84 14 23642 565 42597114
Back pain 38.91 19.84 15 23641 141761 42455918
Haemoglobin decreased 38.08 19.84 13 23643 132458 42465221
Skin exfoliation 37.75 19.84 76 23580 41477 42556202
Lung disorder 36.98 19.84 82 23574 47841 42549838
Asthma 35.65 19.84 95 23561 62219 42535460
Thrombocytopenia 35.52 19.84 32 23624 190247 42407432
Aortic stenosis 35.12 19.84 33 23623 8712 42588967
Cough 34.39 19.84 29 23627 178074 42419605
Septum pellucidum agenesis 34.33 19.84 8 23648 65 42597614
Cardiac failure congestive 33.65 19.84 4 23652 85598 42512081
Lung opacity 33.50 19.84 27 23629 5810 42591869
Neutropenia 33.26 19.84 37 23619 199394 42398285
White blood cell count decreased 33.20 19.84 10 23646 110386 42487293
Myocardial infarction 32.60 19.84 14 23642 123995 42473684
Psoriasis 31.85 19.84 78 23578 48526 42549153
Cardiac failure 31.56 19.84 10 23646 106846 42490833
Bacteroides infection 31.51 19.84 19 23637 2568 42595111
Pancytopenia 31.42 19.84 13 23643 117730 42479949
Steroid withdrawal syndrome 30.83 19.84 10 23646 299 42597380
Diabetes mellitus 30.80 19.84 88 23568 59999 42537680
Platelet count decreased 30.05 19.84 20 23636 138561 42459118
Decreased appetite 29.89 19.84 38 23618 193099 42404580
Rhabdomyolysis 29.81 19.84 4 23652 78015 42519664
Antacid therapy 29.61 19.84 23 23633 4694 42592985
Dehydration 28.72 19.84 22 23634 141745 42455934
Inappropriate schedule of product administration 28.46 19.84 117 23539 95785 42501894
Polydipsia 28.42 19.84 22 23634 4466 42593213
Premature delivery 28.40 19.84 8 23648 146 42597533
Haematochezia 27.48 19.84 83 23573 58353 42539326
Disease progression 26.98 19.84 24 23632 143632 42454047
Congenital hearing disorder 26.78 19.84 7 23649 95 42597584
Alanine aminotransferase increased 26.59 19.84 8 23648 88398 42509281
Intentional product misuse 26.41 19.84 85 23571 61815 42535864
Nasopharyngitis 26.38 19.84 7 23649 83989 42513690
Adverse drug reaction 25.51 19.84 61 23595 37373 42560306
Maternal exposure during pregnancy 25.50 19.84 25 23631 6953 42590726
Bronchopulmonary dysplasia 25.34 19.84 11 23645 746 42596933
Congenital cystic lung 25.20 19.84 8 23648 223 42597456
Blood calcium increased 24.95 19.84 27 23629 8427 42589252
Neonatal respiratory failure 24.81 19.84 9 23647 379 42597300
Renal failure 24.69 19.84 26 23630 143700 42453979
Gait disturbance 24.30 19.84 12 23644 97988 42499691
Corneal endotheliitis 24.11 19.84 6 23650 66 42597613
Seizure 24.04 19.84 19 23637 120542 42477137
Anticoagulant therapy 23.98 19.84 20 23636 4515 42593164
End stage renal disease 23.74 19.84 37 23619 16521 42581158
Loss of consciousness 23.36 19.84 11 23645 92343 42505336
Oxygen saturation decreased 23.15 19.84 4 23652 64683 42532996
Ciliary hyperaemia 22.50 19.84 5 23651 32 42597647
Cardiac arrest 22.09 19.84 17 23639 109303 42488376
Atrial fibrillation 22.07 19.84 27 23629 139566 42458113
Infection 21.92 19.84 18 23638 112050 42485629
Weight increased 21.55 19.84 17 23639 107966 42489713
Renal impairment 21.20 19.84 18 23638 110210 42487469
Ulcer 21.19 19.84 35 23621 16406 42581273
Hypertrophic cardiomyopathy 21.12 19.84 12 23644 1453 42596226
Perioral dermatitis 20.98 19.84 7 23649 229 42597450
Joint swelling 20.74 19.84 6 23650 68016 42529663
Activated partial thromboplastin time prolonged 20.69 19.84 34 23622 15869 42581810
Overdose 20.47 19.84 17 23639 105247 42492432
Hydrops foetalis 20.42 19.84 10 23646 895 42596784
Respiratory disorder neonatal 20.28 19.84 13 23643 1957 42595722
Polyhydramnios 20.24 19.84 7 23649 256 42597423
Skin erosion 20.14 19.84 15 23641 2876 42594803
Persistent corneal epithelial defect 20.09 19.84 5 23651 55 42597624
Vertical infection transmission 19.98 19.84 4 23652 14 42597665
Cryptorchism 19.94 19.84 13 23643 2014 42595665
Congenital pulmonary valve atresia 19.85 19.84 5 23651 58 42597621

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1239.14 13.26 497 56033 30135 110502634
Maternal exposure during pregnancy 703.50 13.26 754 55776 254129 110278640
Appendicolith 453.55 13.26 195 56335 14060 110518709
Exposure during pregnancy 443.31 13.26 485 56045 166939 110365830
Appendicitis 346.90 13.26 203 56327 28261 110504508
Stress 255.99 13.26 292 56238 105056 110427713
Blood phosphorus increased 216.29 13.26 123 56407 16217 110516552
Cardiogenic shock 196.54 13.26 191 56339 57147 110475622
Catarrh 177.88 13.26 83 56447 7252 110525517
Ventricular fibrillation 175.24 13.26 155 56375 41158 110491611
Burns second degree 173.69 13.26 83 56447 7650 110525119
Ascites 171.40 13.26 224 56306 92584 110440185
Infusion site reaction 169.03 13.26 108 56422 17574 110515195
Premature labour 168.94 13.26 86 56444 9086 110523683
Steroid dependence 163.57 13.26 82 56448 8387 110524382
Pulmonary vasculitis 161.47 13.26 75 56455 6485 110526284
Drug eruption 158.66 13.26 165 56365 53494 110479275
Neuritis 146.92 13.26 73 56457 7326 110525443
Hypopnoea 143.49 13.26 83 56447 11297 110521472
Blood uric acid increased 136.19 13.26 102 56428 21427 110511342
Blepharospasm 133.10 13.26 152 56378 54699 110478070
Computerised tomogram thorax abnormal 132.78 13.26 51 56479 2744 110530025
Parosmia 132.22 13.26 83 56447 13097 110519672
Toxicity to various agents 129.83 13.26 42 56488 480513 110052256
Gingival pain 128.25 13.26 87 56443 15649 110517120
Pre-eclampsia 125.04 13.26 69 56461 8581 110524188
Acute kidney injury 125.03 13.26 86 56444 635344 109897425
Myasthenia gravis 123.08 13.26 96 56434 21415 110511354
Eosinophilic granulomatosis with polyangiitis 121.76 13.26 73 56457 10613 110522156
Live birth 119.50 13.26 162 56368 69322 110463447
Total lung capacity abnormal 117.80 13.26 54 56476 4529 110528240
Fall 114.36 13.26 85 56445 603397 109929372
Hyperphosphataemia 113.52 13.26 82 56448 16299 110516470
Respiratory symptom 113.24 13.26 79 56451 14866 110517903
Product use in unapproved indication 111.94 13.26 489 56041 446888 110085881
Back injury 109.38 13.26 128 56402 47271 110485498
Analgesic therapy 107.76 13.26 59 56471 7225 110525544
Hepatic function abnormal 105.97 13.26 175 56355 89120 110443649
Eczema 102.88 13.26 154 56376 72139 110460630
Computerised tomogram thorax 102.36 13.26 28 56502 498 110532271
Urticaria 101.69 13.26 376 56154 318481 110214288
Rhinitis 100.44 13.26 87 56443 22458 110510311
Conjunctivitis allergic 99.40 13.26 55 56475 6876 110525893
Neurological symptom 98.84 13.26 74 56456 15534 110517235
Hypercholesterolaemia 97.19 13.26 170 56360 90667 110442102
Drug therapy 96.80 13.26 55 56475 7236 110525533
Alcohol poisoning 96.04 13.26 59 56471 8961 110523808
Dry mouth 95.72 13.26 271 56259 199677 110333092
Frequent bowel movements 94.42 13.26 147 56383 71243 110461526
Steroid withdrawal syndrome 94.36 13.26 30 56500 915 110531854
Mite allergy 94.22 13.26 50 56480 5753 110527016
Premature baby 93.74 13.26 47 56483 4808 110527961
Dust allergy 92.64 13.26 50 56480 5951 110526818
Diarrhoea 92.41 13.26 288 56242 1139217 109393552
Spirometry abnormal 91.05 13.26 48 56482 5449 110527320
Mycotic allergy 90.22 13.26 49 56481 5905 110526864
Cardiac murmur 89.97 13.26 85 56445 24543 110508226
Abdominal distension 89.41 13.26 243 56287 174860 110357909
Antineutrophil cytoplasmic antibody positive 88.87 13.26 46 56484 5030 110527739
Bronchiectasis 88.31 13.26 101 56429 36392 110496377
Pulmonary alveolar haemorrhage 88.24 13.26 77 56453 20073 110512696
Nightmare 86.44 13.26 103 56427 38760 110494009
Medication error 84.03 13.26 174 56356 105192 110427577
Incorrect route of product administration 83.45 13.26 131 56399 63930 110468839
Hypotension 83.26 13.26 87 56443 523762 110009007
Sleep disorder therapy 82.44 13.26 50 56480 7421 110525348
Pulmonary embolism 82.31 13.26 269 56261 214205 110318564
Stomatitis 82.25 13.26 314 56216 269928 110262841
Epilepsy 81.70 13.26 167 56363 100042 110432727
Colitis ulcerative 77.89 13.26 141 56389 77222 110455547
Therapeutic product effect incomplete 77.33 13.26 271 56259 223534 110309235
Multiple organ dysfunction syndrome 76.91 13.26 210 56320 151500 110381269
Taste disorder 74.70 13.26 126 56404 65261 110467508
Impaired work ability 74.09 13.26 79 56451 26340 110506429
Premature rupture of membranes 72.60 13.26 39 56491 4598 110528171
Breast cancer stage III 71.91 13.26 138 56392 78979 110453790
Neutropenia 71.88 13.26 52 56478 374568 110158201
Sleep disorder 71.64 13.26 244 56286 198400 110334369
Blood pressure inadequately controlled 71.41 13.26 46 56484 7587 110525182
Normal newborn 71.39 13.26 71 56459 21825 110510944
Psoriasis 71.17 13.26 194 56336 139799 110392970
Normochromic normocytic anaemia 67.69 13.26 55 56475 13002 110519767
Impaired quality of life 67.49 13.26 80 56450 29937 110502832
Forced expiratory volume decreased 67.26 13.26 55 56475 13121 110519648
Antacid therapy 66.49 13.26 39 56491 5445 110527324
Preterm premature rupture of membranes 66.14 13.26 26 56504 1489 110531280
Drug abuse 65.82 13.26 7 56523 177404 110355365
Muscle spasms 65.65 13.26 299 56231 277858 110254911
Caesarean section 64.97 13.26 55 56475 13762 110519007
Blood cholesterol increased 64.03 13.26 224 56306 184561 110348208
Capillaritis 63.51 13.26 29 56501 2410 110530359
Onychomadesis 63.14 13.26 96 56434 45567 110487202
Dehydration 63.11 13.26 32 56498 279479 110253290
Iron deficiency 62.26 13.26 61 56469 18415 110514354
Corneal endotheliitis 61.19 13.26 14 56516 114 110532655
Liver function test increased 61.18 13.26 138 56392 88410 110444359
Gestational diabetes 60.56 13.26 41 56489 7348 110525421
Drug interaction 60.16 13.26 102 56428 500081 110032688
Haemoglobin decreased 59.97 13.26 26 56504 248701 110284068
Anticoagulant therapy 59.47 13.26 36 56494 5325 110527444
Aortic stenosis 59.40 13.26 51 56479 13008 110519761
Sleep disorder due to a general medical condition 58.97 13.26 100 56430 52012 110480757
Overlap syndrome 57.47 13.26 43 56487 9016 110523753
Foetal growth restriction 57.34 13.26 29 56501 3021 110529748
Exercise tolerance decreased 56.67 13.26 48 56482 12019 110520750
Skin exfoliation 56.58 13.26 133 56397 87518 110445251
Lung disorder 56.23 13.26 211 56319 179836 110352933
Rectal haemorrhage 55.93 13.26 161 56369 119672 110413097
Pain in extremity 55.87 13.26 433 56097 486685 110046084
Epistaxis 55 13.26 169 56361 130203 110402566
General physical health deterioration 54.42 13.26 388 56142 424907 110107862
Gastrooesophageal reflux disease 53.80 13.26 208 56322 179768 110353001
Condition aggravated 53.35 13.26 592 55938 734244 109798525
Fatigue 53.13 13.26 384 56146 1215574 109317195
Thrombocytopenia 53.10 13.26 60 56470 348825 110183944
Product quality issue 52.87 13.26 120 56410 77179 110455590
Seizure 51.94 13.26 24 56506 221161 110311608
Tubulointerstitial nephritis 50.94 13.26 96 56434 54188 110478581
Macular degeneration 50.81 13.26 59 56471 21600 110511169
Death 50.77 13.26 185 56345 698684 109834085
Multiple drug therapy 50.75 13.26 38 56492 7976 110524793
White blood cell count decreased 50.68 13.26 27 56503 229363 110303406
Hypophosphataemia 50.53 13.26 73 56457 33109 110499660
Renal failure 49.57 13.26 27 56503 226547 110306222
Pulmonary fibrosis 49.47 13.26 139 56391 101903 110430866
Tinnitus 49.46 13.26 101 56429 60439 110472330
Hypoxia 49.25 13.26 162 56368 129353 110403416
Bacterial infection 49.02 13.26 86 56444 45950 110486819
Cardiac failure congestive 48.89 13.26 9 56521 150991 110381778
Swollen tongue 48.48 13.26 100 56430 60262 110472507
Vasculitis 47.60 13.26 74 56456 35799 110496970
Neuralgia 47.07 13.26 87 56443 48391 110484378
Thrombosis 46.90 13.26 142 56388 108520 110424249
Bradycardia 46.78 13.26 11 56519 155506 110377263
Obstructive airways disorder 46.30 13.26 84 56446 46065 110486704
Infection 46.21 13.26 71 56459 362129 110170640
Back pain 46.12 13.26 74 56456 370922 110161847
Diabetes mellitus inadequate control 46.07 13.26 66 56464 29709 110503060
Urinary tract infection 45.55 13.26 60 56470 326222 110206547
Accidental overdose 45.37 13.26 89 56441 51745 110481024
Peripheral venous disease 45.19 13.26 119 56411 83998 110448771
Decreased appetite 44.53 13.26 112 56418 475734 110057035
Chronic sinusitis 43.90 13.26 59 56471 25025 110507744
Atelectasis 43.60 13.26 72 56458 36640 110496129
Hyponatraemia 43.43 13.26 223 56307 217430 110315339
Myocardial infarction 43.33 13.26 22 56508 192061 110340708
Facet joint syndrome 43.17 13.26 128 56402 96700 110436069
Loss of personal independence in daily activities 42.10 13.26 170 56360 149850 110382919
Haematochezia 41.70 13.26 142 56388 115382 110417387
Total lung capacity decreased 41.24 13.26 32 56498 7082 110525687
End stage renal disease 39.88 13.26 52 56478 21421 110511348
Cardiac arrest 39.45 13.26 26 56504 196727 110336042
Arteriosclerosis coronary artery 39.33 13.26 56 56474 25062 110507707
Adverse drug reaction 39.21 13.26 131 56399 105428 110427341
Pancytopenia 39.01 13.26 30 56500 209583 110323186
Intentional overdose 38.63 13.26 10 56520 132491 110400278
Migraine 38.61 13.26 182 56348 171470 110361299
Dysgeusia 38.61 13.26 100 56430 69885 110462884
Activated partial thromboplastin time prolonged 38.21 13.26 52 56478 22316 110510453
Vertigo 37.93 13.26 114 56416 86756 110446013
Depressed level of consciousness 37.87 13.26 6 56524 112272 110420497
Perioral dermatitis 37.29 13.26 14 56516 707 110532062
Rhabdomyolysis 37.25 13.26 8 56522 120393 110412376
Heart rate increased 36.34 13.26 14 56516 143820 110388949
Coma 36.12 13.26 8 56522 117861 110414908
Arthralgia 36.03 13.26 242 56288 779390 109753379
Intentional product use issue 35.73 13.26 233 56297 247673 110285096
Polyhydramnios 35.23 13.26 18 56512 1915 110530854
Asthenia 34.84 13.26 208 56322 688791 109843978
Oligohydramnios 34.75 13.26 23 56507 3971 110528798
Paraesthesia oral 34.69 13.26 62 56468 33609 110499160
Alanine aminotransferase increased 34.58 13.26 26 56504 183747 110349022
Wound infection 34.31 13.26 118 56412 96347 110436422
Amniotic cavity infection 34.17 13.26 14 56516 893 110531876
Arteriosclerosis 34.14 13.26 52 56478 24715 110508054
Hypothyroidism 34.06 13.26 98 56432 72801 110459968
Lung opacity 32.95 13.26 35 56495 11617 110521152
Platelet count decreased 32.53 13.26 42 56488 230401 110302368
Shared psychotic disorder 32.46 13.26 7 56523 42 110532727
Blood calcium increased 32.44 13.26 43 56487 17997 110514772
Full blood count abnormal 31.85 13.26 81 56449 55971 110476798
Somnolence 31.64 13.26 260 56270 297189 110235580
Overdose 31.59 13.26 44 56486 233750 110299019
Haemoptysis 31.49 13.26 94 56436 71260 110461509
Skin weeping 31.27 13.26 21 56509 3714 110529055
HELLP syndrome 31.24 13.26 13 56517 863 110531906
Bacteroides infection 30.84 13.26 19 56511 2900 110529869
International normalised ratio increased 30.75 13.26 4 56526 86768 110446001
Ophthalmic herpes simplex 30.71 13.26 13 56517 901 110531868
Cardiac failure 29.93 13.26 31 56499 187595 110345174
Myelosuppression 29.74 13.26 6 56524 94334 110438435
Rectal cancer metastatic 29.60 13.26 11 56519 540 110532229
Pulmonary valve stenosis congenital 29.43 13.26 5 56525 5 110532764
Placental insufficiency 29.40 13.26 14 56516 1280 110531489
Hypokalaemia 29.27 13.26 30 56500 182418 110350351
Sinusitis 29.18 13.26 68 56462 296620 110236149
Cerebral haemorrhage neonatal 28.96 13.26 5 56525 6 110532763
Syncope 28.50 13.26 37 56493 202499 110330270
Joint swelling 28.44 13.26 123 56407 442722 110090047
Mental status changes 28.24 13.26 3 56527 76119 110456650
Diabetes mellitus 28.18 13.26 113 56417 99268 110433501
Leukopenia 28.06 13.26 21 56509 148770 110383999
Female genital tract fistula 27.61 13.26 38 56492 16481 110516288
Blood test abnormal 27.41 13.26 51 56479 28503 110504266
Hypothalamic pituitary adrenal axis suppression 27.32 13.26 11 56519 671 110532098
Oxygen saturation decreased 27.30 13.26 24 56506 156958 110375811
Blood glucose increased 27.25 13.26 17 56513 132479 110400290
Radiculopathy 27.22 13.26 41 56489 19295 110513474
Constipation 26.68 13.26 290 56240 357496 110175273
Loss of consciousness 26.47 13.26 37 56493 196269 110336500
Foetal heart rate disorder 26.32 13.26 6 56524 48 110532721
Suicide attempt 26.22 13.26 10 56520 103384 110429385
Cervical incompetence 26.05 13.26 10 56520 537 110532232
Neck pain 25.84 13.26 128 56402 123002 110409767
Foetal exposure during pregnancy 25.70 13.26 25 56505 7480 110525289
Disease progression 25.58 13.26 54 56476 243980 110288789
Systemic lupus erythematosus 25.28 13.26 219 56311 254119 110278650
Gout 25.26 13.26 57 56473 36509 110496260
Lactic acidosis 25.22 13.26 8 56522 92803 110439966
Procedural pain 25.20 13.26 56 56474 35509 110497260
Hypoglycaemia 25.15 13.26 14 56516 116090 110416679
Vaginal flatulence 25.07 13.26 31 56499 12113 110520656
Nodule 24.96 13.26 53 56477 32578 110500191
Blood pressure increased 24.78 13.26 60 56470 258313 110274456
Atrial fibrillation 24.75 13.26 50 56480 229592 110303177
Obesity 24.62 13.26 119 56411 113232 110419537
Hyperkalaemia 24.55 13.26 20 56510 135776 110396993
Night sweats 24.46 13.26 134 56396 133849 110398920
Bursitis 24.44 13.26 131 56399 129787 110402982
Illness 24.34 13.26 6 56524 82165 110450604
Corneal perforation 23.74 13.26 11 56519 945 110531824
Gait disturbance 23.36 13.26 69 56461 278139 110254630
Acute respiratory failure 23.28 13.26 5 56525 75255 110457514
Drug ineffective 23.15 13.26 973 55557 1519567 109013202
Maternal condition affecting foetus 22.97 13.26 7 56523 185 110532584
Myalgia 22.65 13.26 50 56480 222331 110310438
Fluid retention 22.49 13.26 10 56520 94297 110438472
Ulcerative keratitis 22.46 13.26 19 56511 4747 110528022
Sepsis 22.44 13.26 261 56269 327085 110205684
Lethargy 22.20 13.26 10 56520 93566 110439203
Hypertension 22.13 13.26 375 56155 509709 110023060
Genital blister 21.91 13.26 7 56523 217 110532552
Chills 21.84 13.26 40 56490 190540 110342229
Hepatic cirrhosis 21.71 13.26 80 56450 67546 110465223
Hyperlipidaemia 21.62 13.26 53 56477 35795 110496974
Polydipsia 21.57 13.26 23 56507 7665 110525104
Dysarthria 21.56 13.26 8 56522 84113 110448656
Chest pain 21.52 13.26 109 56421 376266 110156503
Neonatal gastrointestinal disorder 21.41 13.26 5 56525 45 110532724
Polyglandular disorder 21.26 13.26 7 56523 239 110532530
Tremor 20.98 13.26 45 56485 202187 110330582
Depression 20.86 13.26 251 56279 317084 110215685
Cholestasis of pregnancy 20.82 13.26 11 56519 1254 110531515
Foetal hypokinesia 20.82 13.26 8 56522 431 110532338
Influenza 20.74 13.26 34 56496 169067 110363702
Nail disorder 20.71 13.26 71 56459 57864 110474905
Renal impairment 20.33 13.26 41 56489 188404 110344365
Insomnia 20.29 13.26 105 56425 360485 110172284
Gait inability 20.14 13.26 129 56401 136247 110396522
Respiratory arrest 19.92 13.26 3 56527 58296 110474473
Injection site pain 19.81 13.26 38 56492 177884 110354885
Vaginal discharge 19.77 13.26 34 56496 17874 110514895
Feeling abnormal 19.77 13.26 39 56491 180672 110352097
Inappropriate schedule of product administration 19.53 13.26 174 56356 203463 110329306
Bone erosion 19.44 13.26 60 56470 46311 110486458
Type 2 diabetes mellitus 19.41 13.26 156 56374 177076 110355693
Foetal heart rate deceleration abnormality 19.36 13.26 6 56524 168 110532601
Psoriatic arthropathy 19.32 13.26 169 56361 196592 110336177
Breast cancer stage II 19.27 13.26 43 56487 27332 110505437
Haematocrit decreased 19.25 13.26 5 56525 66112 110466657
Ciliary hyperaemia 19.14 13.26 5 56525 74 110532695
Starvation ketoacidosis 19.09 13.26 7 56523 331 110532438
Product dose omission issue 19.08 13.26 92 56438 321690 110211079
Hypocalcaemia 18.92 13.26 5 56525 65361 110467408
Patent ductus arteriosus 18.87 13.26 6 56524 183 110532586
Agitation 18.81 13.26 18 56512 113033 110419736
Vulvovaginal ulceration 18.69 13.26 4 56526 23 110532746
Delayed delivery 18.69 13.26 4 56526 23 110532746
Chest discomfort 18.61 13.26 38 56492 173810 110358959
Neonatal respiratory depression 18.38 13.26 5 56525 87 110532682
Hallucination 18.26 13.26 15 56515 101417 110431352
Malaise 18.25 13.26 238 56292 671581 109861188
Unresponsive to stimuli 18.24 13.26 5 56525 63785 110468984
Dyspnoea exertional 17.98 13.26 16 56514 104044 110428725
Chronic obstructive pulmonary disease 17.84 13.26 106 56424 109052 110423717
Oropharyngeal pain 17.73 13.26 26 56504 135250 110397519
Skin infection 17.73 13.26 37 56493 22472 110510297
Wheezing 17.70 13.26 204 56326 255026 110277743
Neuropathy peripheral 17.69 13.26 41 56489 179236 110353533
Ulcer haemorrhage 17.66 13.26 37 56493 22534 110510235
Weight increased 17.52 13.26 134 56396 419510 110113259
Atrial septal defect 17.51 13.26 12 56518 2193 110530576
Orthostatic hypotension 17.49 13.26 6 56524 66243 110466526
Persistent corneal epithelial defect 17.45 13.26 5 56525 106 110532663
Gestational hypertension 17.37 13.26 12 56518 2222 110530547
Proctitis 17.22 13.26 31 56499 16896 110515873
Neutrophil count decreased 17.11 13.26 22 56508 120919 110411850
Gastrointestinal haemorrhage 17.03 13.26 37 56493 165481 110367288
Troponin increased 16.89 13.26 43 56487 29723 110503046
Dyskinesia 16.79 13.26 3 56527 51443 110481326
Helicobacter infection 16.72 13.26 154 56376 181723 110351046
Heart rate decreased 16.50 13.26 11 56519 82745 110450024
Osteoarthritis 16.47 13.26 154 56376 182469 110350300
Retroplacental haematoma 16.27 13.26 5 56525 136 110532633
Aggression 16.27 13.26 5 56525 59205 110473564
Disorientation 16.07 13.26 8 56522 70663 110462106
Therapy interrupted 16.06 13.26 3 56527 49819 110482950
Anaplastic astrocytoma 15.87 13.26 5 56525 148 110532621
Angina pectoris 15.84 13.26 6 56524 62289 110470480
Abdominal pain 15.76 13.26 358 56172 512631 110020138
Hot flush 15.75 13.26 7 56523 66029 110466740
Low birth weight baby 15.70 13.26 8 56522 847 110531922
Dermatitis atopic 15.66 13.26 38 56492 25503 110507266
Skin erosion 15.53 13.26 17 56513 5837 110526932
Meningitis chemical 14.93 13.26 6 56524 364 110532405
Depressed mood 14.79 13.26 66 56464 60743 110472026
Anaemia 14.77 13.26 194 56336 546892 109985877
Foetal distress syndrome 14.70 13.26 7 56523 640 110532129
Ulcer 14.68 13.26 52 56478 43064 110489705
Pneumonia aspiration 14.64 13.26 12 56518 81221 110451548
Encephalopathy 14.57 13.26 12 56518 81043 110451726
Intentional product misuse 14.56 13.26 117 56413 132787 110399982
Pulmonary hilum mass 14.54 13.26 6 56524 390 110532379
Lichenification 14.45 13.26 8 56522 1001 110531768
Impaired healing 14.44 13.26 159 56371 196558 110336211
Glycogen storage disorder 14.37 13.26 3 56527 15 110532754
Somatostatin receptor scan abnormal 14.37 13.26 3 56527 15 110532754
Breast injury 14.23 13.26 4 56526 79 110532690
Arthritis allergic 14.21 13.26 3 56527 16 110532753
Rhinorrhoea 14.19 13.26 19 56511 102647 110430122
Anaemia folate deficiency 14.16 13.26 7 56523 694 110532075
Maternal exposure before pregnancy 14.13 13.26 18 56512 7247 110525522
Chronic kidney disease 14.08 13.26 11 56519 76280 110456489
Cardiac disorder 14.08 13.26 11 56519 76269 110456500
Shock 13.89 13.26 5 56525 53583 110479186
Gamma-glutamyltransferase increased 13.85 13.26 7 56523 61302 110471467
Umbilical cord prolapse 13.77 13.26 3 56527 19 110532750
Lymphocyte count decreased 13.76 13.26 6 56524 57237 110475532
Exostosis 13.62 13.26 53 56477 45903 110486866
Oral candidiasis 13.58 13.26 52 56478 44708 110488061
Bronchopulmonary aspergillosis allergic 13.51 13.26 19 56511 8407 110524362
Adrenal insufficiency 13.48 13.26 50 56480 42340 110490429
Post inflammatory pigmentation change 13.48 13.26 7 56523 770 110531999
Injection site erythema 13.45 13.26 17 56513 94159 110438610
Pain 13.34 13.26 379 56151 954576 109578193

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07BC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, potent, combinations with antiseptics
ATC D07CC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC D07XC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, potent, other combinations
ATC H02AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01BB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA07 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:77715 nasal decongestant
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents

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D07BC Corticosteroids, potent, combinations with antiseptics 3 drugs
diflucortolonefluocinolone acetonidefluocortolone
D07CC Corticosteroids, potent, combinations with antibiotics 5 drugs
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desoximetasonediflucortolonefluocortolonemometasone furoate
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R01AD Corticosteroids 12 drugs
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R03BA Glucocorticoids 8 drugs
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S01BA Corticosteroids, plain 15 drugs
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S01CA Corticosteroids and antiinfectives in combination 11 drugs
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dexamethasonefluorometholonehydrocortisoneprednisolone
S02BA Corticosteroids 4 drugs
dexamethasonefluocinolone acetonidehydrocortisoneprednisolone
S03BA Corticosteroids 2 drugs
dexamethasoneprednisolone
S03CA Corticosteroids and antiinfectives in combination 5 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Congenital ichthyosis of skin contraindication 13059002
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Hypervitaminosis D contraindication 27712000 DOID:9971
Guttate psoriasis contraindication 37042000
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Hypercalcemia contraindication 66931009 DOID:12678
Psychotic disorder contraindication 69322001
Disorder of calcium metabolism contraindication 71638002 DOID:10575
Hypercalciuria contraindication 71938000
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Pustular psoriasis contraindication 200973000
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 8.07 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4018644 VUID
N0000146957 NUI
D00244 KEGG_DRUG
1514 RXNORM
C0005308 UMLSCUI
CHEBI:3077 CHEBI
CHEMBL632 ChEMBL_ID
DB00443 DRUGBANK_ID
7061 IUPHAR_LIGAND_ID
1045 INN_ID
9842X06Q6M UNII
9782 PUBCHEM_CID
10006 MMSL
4270 MMSL
d00628 MMSL
D001623 MESH_DESCRIPTOR_UI
4018644 VANDF
002168 NDDF
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US
9842X06Q6M INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DR. THROWERS BETA HUMAN PRESCRIPTION DRUG LABEL 1 69299-202 OINTMENT 0.05 g TOPICAL unapproved drug other 4 sections