sodium borate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4795 1330-43-4

Description:

MoleculeDescription

Synonyms:

  • sodium borate
  • borax
  • sodium tetraborate
see also sodium borate
  • Molecular weight: 201.21
  • Formula: B4Na2O7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 107.95
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 302.15 17.74 81 6863 9386 90612117
Pulmonary toxicity 277.30 17.74 79 6865 11452 90610051
Neoplasm malignant 211.13 17.74 84 6860 33796 90587707
Joint injury 203.59 17.74 81 6863 32583 90588920
Hepatotoxicity 202.72 17.74 89 6855 45753 90575750
Therapy non-responder 103.84 17.74 85 6859 136619 90484884
Joint stiffness 103.58 17.74 68 6876 77974 90543529
Musculoskeletal pain 98.79 17.74 91 6853 171160 90450343
Therapeutic product effect incomplete 89.21 17.74 91 6853 193805 90427698
C-reactive protein abnormal 81.90 17.74 72 6872 127357 90494146
Vaginal flatulence 70.61 17.74 29 6915 12609 90608894
Proctitis 65.34 17.74 29 6915 15230 90606273
Female genital tract fistula 60.97 17.74 29 6915 17839 90603664
Radiculopathy 60.00 17.74 29 6915 18476 90603027
Vaginal discharge 58.61 17.74 29 6915 19435 90602068
Pain in extremity 58.38 17.74 115 6829 450414 90171089
Musculoskeletal stiffness 56.94 17.74 90 6854 296442 90325061
Procedural pain 54.04 17.74 33 6911 33327 90588176
Colitis ulcerative 53.25 17.74 41 6903 60225 90561278
Chronic sinusitis 53.10 17.74 29 6915 23773 90597730
Paraesthesia oral 47.93 17.74 30 6914 31629 90589874
Oral candidiasis 44.83 17.74 30 6914 35425 90586078
Haematochezia 43.38 17.74 39 6905 70874 90550629
Macular degeneration 42.96 17.74 30 6914 37940 90583563
Frequent bowel movements 42.31 17.74 35 6909 56900 90564603
Treatment failure 41.01 17.74 79 6865 303849 90317654
Infection 37.03 17.74 84 6860 362010 90259493
Allergy to chemicals 29.38 17.74 11 6933 3743 90617760
Red blood cell sedimentation rate decreased 28.90 17.74 8 6936 1040 90620463
Synovial fluid analysis 28.58 17.74 10 6934 2808 90618695
Rectal haemorrhage 27.83 17.74 33 6911 82711 90538792
Synovial disorder 27.59 17.74 10 6934 3108 90618395
Colitis 27.08 17.74 30 6914 69912 90551591
Joint swelling 26.76 17.74 92 6852 503208 90118295
Antinuclear antibody positive 25.55 17.74 13 6931 9228 90612275
Tenosynovitis stenosans 25.28 17.74 10 6934 3943 90617560
Arthropathy 25 17.74 73 6871 366169 90255334
Hepatic enzyme decreased 24.98 17.74 7 6937 951 90620552
Eye irritation 23.40 17.74 20 6924 33958 90587545
Scleritis 22.62 17.74 10 6934 5198 90616305
Erythema 22.09 17.74 52 6892 229194 90392309
Condition aggravated 20.47 17.74 95 6849 595450 90026053
Arthralgia 20.36 17.74 115 6829 778407 89843096
Synovial cyst 19.99 17.74 12 6932 11740 90609763
Drug hypersensitivity 19.80 17.74 79 6865 463530 90157973
Cushingoid 18.68 17.74 11 6933 10384 90611119

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Periarthritis 32.47 24.28 8 1575 1372 42618380
Testicular haemorrhage 26.32 24.28 5 1578 252 42619500

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 182.92 18.65 55 7284 11093 110570867
Pulmonary toxicity 157.78 18.65 55 7284 17691 110564269
Neoplasm malignant 131.03 18.65 59 7280 37084 110544876
Joint injury 123.76 18.65 58 7281 39936 110542024
Hepatotoxicity 109.23 18.65 62 7277 63338 110518622
Joint stiffness 82.78 18.65 53 7286 67190 110514770
Vaginal flatulence 75.77 18.65 29 7310 12115 110569845
Female genital tract fistula 67.14 18.65 29 7310 16490 110565470
Proctitis 66.46 18.65 29 7310 16898 110565062
Vaginal discharge 64.89 18.65 29 7310 17879 110564081
Radiculopathy 62.76 18.65 29 7310 19307 110562653
Macular degeneration 62.65 18.65 30 7309 21629 110560331
Colitis ulcerative 62.32 18.65 47 7292 77316 110504644
Therapy non-responder 57.30 18.65 61 7278 157246 110424714
Procedural pain 56.47 18.65 33 7306 35532 110546428
Musculoskeletal pain 56.37 18.65 65 7274 182958 110399002
Chronic sinusitis 55.59 18.65 29 7310 25055 110556905
Therapeutic product effect incomplete 55.15 18.65 71 7268 223734 110358226
Frequent bowel movements 52.31 18.65 41 7298 71349 110510611
Paraesthesia oral 50.20 18.65 30 7309 33641 110548319
Haematochezia 42.40 18.65 45 7294 115479 110466481
C-reactive protein abnormal 41.49 18.65 47 7292 129648 110452312
Oral candidiasis 40.10 18.65 29 7310 44731 110537229
Pain in extremity 32.67 18.65 88 7251 487030 110094930
Allergy to chemicals 32.23 18.65 11 7328 3314 110578646
Synovial fluid analysis 30.48 18.65 10 7329 2671 110579289
Musculoskeletal stiffness 30.24 18.65 61 7278 279761 110302199
Rectal haemorrhage 29.45 18.65 38 7301 119795 110462165
Synovial disorder 29.35 18.65 10 7329 2997 110578963
Red blood cell sedimentation rate decreased 28.12 18.65 8 7331 1326 110580634
Infection 27.94 18.65 69 7270 362131 110219829
Tenosynovitis stenosans 27.58 18.65 10 7329 3593 110578367
Therapeutic reaction time decreased 27.27 18.65 11 7328 5268 110576692
Hepatic enzyme decreased 25.67 18.65 7 7332 995 110580965
Synovial cyst 24.71 18.65 13 7326 11417 110570543
Colitis 24.44 18.65 32 7307 102291 110479669
Antinuclear antibody positive 24.40 18.65 12 7327 9156 110572804
Abdominal pain 24.29 18.65 82 7257 512907 110069053
Erythema 24.05 18.65 57 7282 291390 110290570
Treatment failure 23.72 18.65 55 7284 277179 110304781
Scleritis 23.62 18.65 10 7329 5410 110576550
Testicular haemorrhage 23.50 18.65 5 7334 248 110581712
Constipation 22.33 18.65 63 7276 357723 110224237
Dyspepsia 22.27 18.65 43 7296 190922 110391038
Joint swelling 20.25 18.65 70 7269 442775 110139185
Quality of life decreased 19.51 18.65 12 7327 14157 110567803
Cushingoid 18.93 18.65 11 7328 11701 110570259
Rheumatoid arthritis 18.92 18.65 53 7286 299560 110282400

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01AX07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
CHEBI has role CHEBI:50267 protective agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

S01AX Other antiinfectives 13 drugs
bibrocatholcethexoniumchlorhexidinedibrompropamidinehexamidinelotilanernitrofurazonepicloxydinepolihexanidepovidone-iodinepropamidineresorcinol show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
91MBZ8H3QO UNII
D03243 KEGG_DRUG
4024916 VUID
N0000147505 NUI
4019309 VANDF
4024916 VANDF
C0074727 UMLSCUI
CHEBI:38909 CHEBI
CHEMBL3833375 ChEMBL_ID
16211214 PUBCHEM_CID
DB14505 DRUGBANK_ID
CHEMBL2097011 ChEMBL_ID
CHEMBL1076681 ChEMBL_ID
C010634 MESH_SUPPLEMENTAL_RECORD_UI
C018851 MESH_SUPPLEMENTAL_RECORD_UI
36680 RXNORM
5210 MMSL
5475 MMSL
NOCODE MMSL
001980 NDDF
011732 NDDF
50306007 SNOMEDCT_US
1303-96-4 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcemin Advance HUMAN OTC DRUG LABEL 5 0280-0272 TABLET, FILM COATED 2.45 mg ORAL Export only 1 sections
MA YING LONG HEMORRHOIDAL HUMAN OTC DRUG LABEL 7 69396-006 OINTMENT 0.20 g TOPICAL unapproved drug other 11 sections
Miel Rosada HUMAN OTC DRUG LABEL 2 70242-127 SOLUTION 0.10 mg TOPICAL OTC Monograph Drug 8 sections
Borax HUMAN OTC DRUG LABEL 1 79718-1023 LIQUID 30 [hp_C] ORAL unapproved homeopathic 7 sections
Borax HUMAN OTC DRUG LABEL 1 79718-1164 LIQUID 200 [hp_C] ORAL unapproved homeopathic 8 sections