potassium iodide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
radiopharmaceuticals, iodine-contained 4296 7681-11-0

Description:

MoleculeDescription

Synonyms:

  • potassium iodide
  • kalium iodidum
  • potassium monoiodide
An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed)
  • Molecular weight: 166.00
  • Formula: IK
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1.20 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Nov. 9, 1979 FDA MEDPOINTE PHARM HLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Contraindicated product administered 138.14 11.20 4 44311 320135 90263997
Synovitis 135.77 11.20 6 44309 329746 90254386
Systemic lupus erythematosus 122.80 11.20 16 44299 361880 90222252
Product dose omission issue 120.22 11.20 364 43951 291323 90292809
Glossodynia 117.32 11.20 11 44304 321768 90262364
Diarrhoea 112.60 11.20 814 43501 938376 89645756
Infusion related reaction 105.70 11.20 36 44279 416744 90167388
Pericarditis 104.71 11.20 7 44308 270144 90313988
Treatment failure 101.75 11.20 14 44301 303914 90280218
Wound 99.00 11.20 15 44300 302965 90281167
Helicobacter infection 93.76 11.20 4 44311 226846 90357286
Drug intolerance 91.01 11.20 53 44262 447538 90136594
Off label use 90.32 11.20 260 44055 1101992 89482140
Fall 85.31 11.20 462 43853 481348 90102784
Folliculitis 83.16 11.20 4 44311 204349 90379783
Product use issue 82.75 11.20 29 44286 329890 90254242
Product use in unapproved indication 81.89 11.20 31 44284 336205 90247927
Maternal exposure during pregnancy 78.49 11.20 39 44276 360024 90224108
Unevaluable event 73.57 11.20 111 44204 54737 90529395
Lower respiratory tract infection 70.16 11.20 18 44297 250641 90333491
Hepatic enzyme increased 70.11 11.20 45 44270 360691 90223441
Arthropathy 69.41 11.20 47 44268 366195 90217937
Device expulsion 68.48 11.20 92 44223 40794 90543338
Intentional product use issue 65.87 11.20 13 44302 216879 90367253
Feeling abnormal 65.35 11.20 205 44110 167030 90417102
Fatigue 65.12 11.20 854 43461 1153169 89430963
Type 2 diabetes mellitus 62.10 11.20 12 44303 203232 90380900
Irritable bowel syndrome 59.80 11.20 14 44301 207434 90376698
Muscle spasms 59.15 11.20 262 44053 251621 90332511
Therapeutic product effect decreased 59.07 11.20 31 44284 277540 90306592
Full blood count decreased 56.26 11.20 71 44244 29618 90554514
Nausea 55.38 11.20 804 43511 1109512 89474620
Flatulence 54.45 11.20 83 44232 41284 90542848
Therapeutic product effect incomplete 54.11 11.20 14 44301 193882 90390250
Drug hypersensitivity 53.76 11.20 90 44225 463519 90120613
Deep vein thrombosis 52.31 11.20 129 44186 91491 90492641
Liver injury 52.25 11.20 10 44305 170557 90413575
Toxicity to various agents 50.54 11.20 40 44275 287806 90296326
Device dislocation 49.94 11.20 69 44246 31413 90552719
Neuropathy peripheral 49.06 11.20 163 44152 136807 90447325
Therapy cessation 47.92 11.20 73 44242 36288 90547844
Blister 47.92 11.20 33 44282 254965 90329167
C-reactive protein increased 47.10 11.20 15 44300 181374 90402758
Impaired healing 44.41 11.20 30 44285 234169 90349963
Fibromyalgia 43.93 11.20 23 44292 206246 90377886
Ill-defined disorder 43.42 11.20 18 44297 184873 90399259
Haemoglobin decreased 43.06 11.20 175 44140 161781 90422351
Discomfort 42.32 11.20 43 44272 274292 90309840
Dizziness 41.78 11.20 456 43859 588828 89995304
Dehydration 40.98 11.20 196 44119 194251 90389881
Hot flush 40.78 11.20 90 44225 59398 90524734
Plasma cell myeloma 37.81 11.20 70 44245 40758 90543374
Joint range of motion decreased 37.44 11.20 10 44305 135633 90448499
Constipation 37.43 11.20 250 44065 280145 90303987
Asthenia 36.89 11.20 411 43904 533340 90050792
Back pain 36.62 11.20 273 44042 316902 90267230
Progressive bulbar palsy 36.51 11.20 8 44307 55 90584077
Prescribed overdose 36.46 11.20 3 44312 97622 90486510
Urinary tract infection 35.81 11.20 264 44051 305368 90278764
Bursitis 35.79 11.20 10 44305 131644 90452488
Joint swelling 33.93 11.20 129 44186 503171 90080961
Pulmonary embolism 33.69 11.20 140 44175 130680 90453452
Obstructive defaecation 33.41 11.20 10 44305 260 90583872
Stoma site dermatitis 32.84 11.20 10 44305 276 90583856
Rheumatoid arthritis 31.41 11.20 83 44232 362531 90221601
Psoriasis 31.17 11.20 149 44166 147605 90436527
Pneumonia 30.83 11.20 460 43855 637599 89946533
Injection site erythema 30.72 11.20 112 44203 98390 90485742
Hypercholesterolaemia 30.71 11.20 6 44309 100886 90483246
Obesity 30.63 11.20 7 44308 105500 90478632
Headache 30.44 11.20 591 43724 862155 89721977
Intentional overdose 29.82 11.20 5 44310 93829 90490303
Wheezing 29.66 11.20 44 44271 238036 90346096
Balance disorder 29.12 11.20 109 44206 96971 90487161
Hypersensitivity 29.07 11.20 119 44196 454558 90129574
Gastrointestinal stoma output abnormal 29.06 11.20 10 44305 410 90583722
Hip fracture 28.51 11.20 55 44260 33022 90551110
General physical health deterioration 28.01 11.20 85 44230 355030 90229102
Alopecia 27.79 11.20 136 44179 494935 90089197
Peripheral venous disease 27.74 11.20 4 44311 83917 90500215
Sleep disorder 27.29 11.20 34 44281 197996 90386136
Grip strength decreased 27.16 11.20 6 44309 92570 90491562
Drug ineffective 27.04 11.20 496 43819 1383802 89200330
Gastrointestinal disorder 26.88 11.20 53 44262 256634 90327498
COVID-19 26.56 11.20 26 44289 168817 90415315
Motor neurone disease 26.55 11.20 8 44307 213 90583919
Blood cholesterol increased 26.35 11.20 38 44277 207974 90376158
Influenza like illness 26.28 11.20 93 44222 80518 90503614
Wound infection 25.56 11.20 10 44305 106392 90477740
Injection site haemorrhage 25.53 11.20 48 44267 28270 90555862
Asthma 25.36 11.20 50 44265 242110 90342022
Pelvic pain 24.87 11.20 34 44281 15323 90568809
Vision blurred 24.56 11.20 113 44202 110180 90473952
Injection site pain 24.45 11.20 157 44158 173542 90410590
Tremor 23.79 11.20 142 44173 153031 90431101
Dyspnoea 23.25 11.20 579 43736 880376 89703756
Stoma site inflammation 23.12 11.20 10 44305 764 90583368
Stoma site pain 22.92 11.20 12 44303 1405 90582727
Epilepsy 22.80 11.20 6 44309 82200 90501932
Atrial fibrillation 22.79 11.20 127 44188 133484 90450648
Vaginal haemorrhage 22.21 11.20 48 44267 31223 90552909
Nasal congestion 22.04 11.20 90 44225 83324 90500808
Blood potassium decreased 21.93 11.20 62 44253 47665 90536467
White blood cell count decreased 21.68 11.20 148 44167 166961 90417171
Swelling 21.32 11.20 119 44196 418939 90165193
Platelet count decreased 21.28 11.20 127 44188 136842 90447290
Multiple sclerosis relapse 21.22 11.20 65 44250 52240 90531892
Infection 21.16 11.20 98 44217 361996 90222136
Laboratory test abnormal 20.85 11.20 56 44259 41798 90542334
Skin discolouration 20.79 11.20 58 44257 44257 90539875
Overdose 20.78 11.20 28 44287 157681 90426451
Hypervolaemia 20.71 11.20 48 44267 32709 90551423
Autoimmune disorder 20.54 11.20 6 44309 76738 90507394
Lung disorder 20.37 11.20 26 44289 149857 90434275
Inflammation 20.36 11.20 35 44280 178557 90405575
Pulmonary fibrosis 20.06 11.20 14 44301 107489 90476643
Suicide attempt 19.99 11.20 6 44309 75393 90508739
Dyspnoea exertional 19.90 11.20 79 44236 72209 90511923
Hypoxia 19.84 11.20 79 44236 72320 90511812
Adverse event 19.74 11.20 17 44298 117401 90466731
Eye swelling 19.62 11.20 44 44271 29342 90554790
Gastrointestinal stoma complication 19.35 11.20 13 44302 2406 90581726
Cardiac failure congestive 19.00 11.20 97 44218 98597 90485535
Stomatitis 18.75 11.20 70 44245 274628 90309504
Hypertension 18.65 11.20 139 44176 457393 90126739
Cough 18.56 11.20 268 44047 368694 90215438
Chills 18.39 11.20 119 44196 131862 90452270
Pulmonary arterial hypertension 18.38 11.20 40 44275 26147 90557985
Pulmonary hypertension 18.34 11.20 54 44261 42469 90541663
Spinal fracture 18.23 11.20 36 44279 21980 90562152
Lethargy 18.19 11.20 70 44245 63069 90521063
Live birth 18.09 11.20 8 44307 79099 90505033
Fluid retention 17.97 11.20 88 44227 88003 90496129
Thrombosis 17.77 11.20 77 44238 73174 90510958
Lumbar vertebral fracture 17.69 11.20 20 44295 7438 90576694
Product complaint 17.64 11.20 27 44288 13473 90570659
Underweight 17.57 11.20 10 44305 1380 90582752
Oedema peripheral 17.49 11.20 198 44117 257717 90326415
Dysgeusia 17.44 11.20 61 44254 52499 90531633
Hiccups 16.73 11.20 13 44302 3013 90581119
Abdominal discomfort 16.72 11.20 151 44164 477177 90106955
Compression fracture 16.62 11.20 21 44294 8768 90575364
Hospice care 16.50 11.20 22 44293 9682 90574450
Red blood cell sedimentation rate increased 16.44 11.20 10 44305 82585 90501547
Mobility decreased 16.39 11.20 65 44250 250669 90333463
Flushing 16.36 11.20 86 44229 88405 90495727
Illness 16.21 11.20 10 44305 81959 90502173
Depression 16.18 11.20 221 44094 300380 90283752
Faeces hard 15.94 11.20 13 44302 3229 90580903
Condition aggravated 15.78 11.20 201 44114 595344 89988788
Bone pain 15.69 11.20 66 44249 61917 90522215
Drug interaction 15.45 11.20 76 44239 276377 90307755
Defaecation urgency 15.25 11.20 17 44298 6225 90577907
Amyotrophic lateral sclerosis 15.19 11.20 9 44306 1339 90582793
Cellulitis 15.03 11.20 86 44229 91251 90492881
Intentional product misuse 15.03 11.20 13 44302 89591 90494541
Swelling face 15.00 11.20 79 44236 81273 90502859
Mood swings 14.96 11.20 32 44283 20670 90563462
International normalised ratio increased 14.92 11.20 54 44261 47262 90536870
Pulmonary oedema 14.86 11.20 65 44250 62015 90522117
Syncope 14.61 11.20 113 44202 132550 90451582
Dry skin 14.54 11.20 83 44232 87990 90496142
Myalgia 14.49 11.20 140 44175 174985 90409147
Pleural effusion 14.41 11.20 99 44216 111892 90472240
Body height decreased 14.36 11.20 23 44292 11926 90572206
Administration site swelling 14.31 11.20 9 44306 1490 90582642
Weight decreased 14.27 11.20 263 44052 379647 90204485
Injection site bruising 14.27 11.20 57 44258 52250 90531882
Musculoskeletal stiffness 14.11 11.20 86 44229 296446 90287686
Tooth disorder 13.91 11.20 40 44275 31050 90553082
Anaemia 13.87 11.20 246 44069 352556 90231576
Red blood cell count decreased 13.86 11.20 52 44263 46299 90537833
Blepharospasm 13.66 11.20 5 44310 55440 90528692
Gallbladder disorder 13.61 11.20 30 44285 19773 90564359
Liver disorder 13.60 11.20 24 44291 121245 90462887
Thoracic outlet syndrome 13.56 11.20 6 44309 484 90583648
Injection site mass 13.56 11.20 32 44283 22058 90562074
Eructation 13.15 11.20 21 44294 10861 90573271
Intestinal obstruction 13.11 11.20 44 44271 37087 90547045
Exposure during pregnancy 13.06 11.20 66 44249 238344 90345788
Plasma cell myeloma recurrent 12.97 11.20 13 44302 4215 90579917
Intestinal dilatation 12.94 11.20 10 44305 2300 90581832
Heavy menstrual bleeding 12.89 11.20 30 44285 20500 90563632
Multiple allergies 12.82 11.20 25 44290 15121 90569011
Multiple sclerosis 12.63 11.20 36 44279 27804 90556328
Epistaxis 12.63 11.20 78 44237 85047 90499085
Anxiety 12.53 11.20 217 44098 309555 90274577
Cardiac pacemaker insertion 12.52 11.20 13 44302 4394 90579738
Laryngeal pain 12.48 11.20 13 44302 4409 90579723
Pollakiuria 12.45 11.20 40 44275 32965 90551167
Hypophagia 12.18 11.20 42 44273 35895 90548237
Restless legs syndrome 12.15 11.20 31 44284 22439 90561693
Osteoarthritis 12.01 11.20 52 44263 195678 90388454
Nail disorder 11.97 11.20 7 44308 59060 90525072
Cardiac disorder 11.73 11.20 57 44258 56815 90527317
Nervousness 11.71 11.20 40 44275 34016 90550116
Incorrect dose administered 11.50 11.20 72 44243 78858 90505274
Confusional state 11.50 11.20 127 44188 386078 90198054
Visual acuity reduced 11.34 11.20 31 44284 23379 90560753
Blood glucose decreased 11.32 11.20 31 44284 23398 90560734
Pain in jaw 11.30 11.20 50 44265 47935 90536197
Burning sensation 11.28 11.20 61 44254 63391 90520741

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 103.42 12.47 134 24816 638201 41958184
Fatigue 71.46 12.47 467 24483 435174 42161211
Plasma cell myeloma 58.37 12.47 102 24848 47476 42548909
Diarrhoea 47.61 12.47 444 24506 460405 42135980
Asthenia 43.43 12.47 297 24653 280496 42315889
Product dose omission issue 42.52 12.47 191 24759 154174 42442211
Laboratory test abnormal 41.72 12.47 59 24891 22919 42573466
Product use in unapproved indication 40.98 12.47 29 24921 184427 42411958
Drug interaction 40.01 12.47 59 24891 266940 42329445
Completed suicide 39.40 12.47 5 24945 96460 42499925
Fall 39.22 12.47 253 24697 234267 42362118
Full blood count decreased 39.13 12.47 54 24896 20506 42575879
White blood cell count decreased 37.75 12.47 146 24804 110250 42486135
Toxicity to various agents 31.13 12.47 54 24896 229082 42367303
Dizziness 29.14 12.47 247 24703 249007 42347378
Dopamine transporter scintigraphy abnormal 27.08 12.47 5 24945 9 42596376
Pneumonia 26.77 12.47 370 24580 421779 42174606
Adverse drug reaction 26.54 12.47 64 24886 37370 42559015
Intentional product use issue 22.52 12.47 7 24943 71826 42524559
Viral infection 22.28 12.47 44 24906 22439 42573946
COVID-19 22.28 12.47 21 24929 115927 42480458
Sinusitis 20.83 12.47 68 24882 47224 42549161
Dehydration 20.12 12.47 147 24803 141620 42454765
Psoriasis 19.73 12.47 68 24882 48536 42547849
Muscle spasms 19.69 12.47 101 24849 85943 42510442
Cardiac disorder 19.47 12.47 68 24882 48864 42547521
Influenza 19.44 12.47 80 24870 62095 42534290
Overdose 19.15 12.47 20 24930 105244 42491141
Neuropathy peripheral 18.93 12.47 113 24837 101740 42494645
Rash 18.42 12.47 245 24705 276709 42319676
Peripheral swelling 17.97 12.47 102 24848 90168 42506217
Intentional product misuse 17.74 12.47 7 24943 61893 42534492
Regurgitation 17.43 12.47 12 24938 1928 42594457
Febrile neutropenia 16.99 12.47 54 24896 185649 42410736
Constipation 16.95 12.47 157 24793 162134 42434251
Drug ineffective 16.80 12.47 264 24686 629933 41966452
Interstitial lung disease 16.54 12.47 13 24937 78449 42517936
Eructation 16.24 12.47 18 24932 5468 42590917
Haemoglobin decreased 15.29 12.47 131 24819 132340 42464045
Memory impairment 15.21 12.47 64 24886 50158 42546227
Influenza like illness 15.13 12.47 47 24903 31793 42564592
Muscular weakness 15.10 12.47 92 24858 83406 42512979
Unevaluable event 14.82 12.47 49 24901 34239 42562146
Cytokine release syndrome 14.58 12.47 4 24946 44523 42551862
Platelet count decreased 14.43 12.47 134 24816 138447 42457938
Small intestinal obstruction 14.11 12.47 31 24919 17030 42579355
Multiple organ dysfunction syndrome 13.96 12.47 22 24928 97013 42499372
Coma 13.87 12.47 7 24943 53547 42542838
Mental status changes 13.81 12.47 55 24895 42060 42554325
Hypoaesthesia 13.73 12.47 80 24870 71383 42525002
Flatulence 13.73 12.47 39 24911 25113 42571272
Fluid retention 13.50 12.47 45 24905 31574 42564811
General physical health deterioration 13.12 12.47 45 24905 151201 42445184
Hepatic function abnormal 12.97 12.47 7 24943 51560 42544825
Thrombosis 12.71 12.47 76 24874 68435 42527950
Feeling abnormal 12.69 12.47 77 24873 69709 42526676
Cellulitis 12.52 12.47 70 24880 61515 42534870

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 155.23 11.16 324 54901 1499861 109034213
Product dose omission issue 116.08 11.16 389 54836 321393 110212681
Contraindicated product administered 106.37 11.16 4 55221 248263 110285811
Fall 105.80 11.16 586 54639 602896 109931178
Product use in unapproved indication 98.83 11.16 50 55175 447327 110086747
Completed suicide 97.13 11.16 6 55219 242375 110291699
Diarrhoea 93.63 11.16 923 54302 1138582 109395492
Systemic lupus erythematosus 89.22 11.16 11 55214 254327 110279747
Treatment failure 83.85 11.16 18 55207 277216 110256858
Drug intolerance 83.15 11.16 50 55175 406462 110127612
Infusion related reaction 79.20 11.16 46 55179 381116 110152958
Device expulsion 77.24 11.16 86 55139 30805 110503269
Toxicity to various agents 76.83 11.16 76 55149 480479 110053595
Fatigue 76.37 11.16 934 54291 1215024 109319050
Drug abuse 75.50 11.16 3 55222 177408 110356666
Duodenal ulcer perforation 72.41 11.16 4 55221 177696 110356378
Glossodynia 72.27 11.16 12 55213 221992 110312082
Helicobacter infection 71.39 11.16 5 55220 181872 110352202
Intentional product use issue 71.19 11.16 18 55207 247888 110286186
Plasma cell myeloma 69.61 11.16 118 55107 62818 110471256
Dizziness 68.49 11.16 588 54637 697605 109836469
Product use issue 65.62 11.16 37 55188 311658 110222416
Lower respiratory tract infection 65.43 11.16 20 55205 243086 110290988
Pericarditis 64.69 11.16 15 55210 219099 110314975
Asthenia 64.32 11.16 574 54651 688425 109845649
Folliculitis 61.96 11.16 6 55219 167647 110366427
Dehydration 58.22 11.16 285 54940 279226 110254848
Therapeutic product effect incomplete 57.43 11.16 20 55205 223785 110310289
Deep vein thrombosis 55.67 11.16 175 55050 139712 110394362
Hepatic enzyme increased 53.30 11.16 49 55176 320843 110213231
Nausea 51.14 11.16 883 54342 1234807 109299267
Feeling abnormal 51.12 11.16 202 55023 180509 110353565
Irritable bowel syndrome 51.01 11.16 10 55215 164205 110369869
Haemoglobin decreased 49.93 11.16 251 54974 248476 110285598
Therapy cessation 49.46 11.16 84 55141 44773 110489301
Maternal exposure during pregnancy 48.48 11.16 34 55191 254849 110279225
Full blood count decreased 46.32 11.16 68 55157 32031 110502043
Wound 46.29 11.16 30 55195 234407 110299667
COVID-19 46.20 11.16 33 55192 245027 110289047
Arthropathy 45.31 11.16 46 55179 287476 110246598
Type 2 diabetes mellitus 45.19 11.16 16 55209 177216 110356858
Intentional overdose 43.48 11.16 7 55218 132494 110401580
C-reactive protein increased 42.87 11.16 28 55197 217891 110316183
Device dislocation 42.66 11.16 65 55160 31639 110502435
Dyspnoea 42.55 11.16 782 54443 1106090 109427984
Fibromyalgia 40.96 11.16 17 55208 170892 110363182
Unevaluable event 40.88 11.16 91 55134 59136 110474938
Muscle spasms 40.78 11.16 258 54967 277899 110256175
Drug interaction 40.51 11.16 122 55103 500061 110034013
Drug hypersensitivity 40.28 11.16 106 55119 453984 110080090
Pneumonia 38.17 11.16 632 54593 876082 109657992
Flatulence 38.13 11.16 82 55143 52067 110482007
Intentional product misuse 37.47 11.16 10 55215 132894 110401180
Drug ineffective 37.09 11.16 536 54689 1520004 109014070
Ill-defined disorder 35.39 11.16 17 55208 156836 110377238
Dopamine transporter scintigraphy abnormal 35.38 11.16 7 55218 26 110534048
Amaurosis fugax 34.78 11.16 19 55206 2371 110531703
Obstructive defaecation 33.50 11.16 10 55215 252 110533822
Therapeutic product effect decreased 33.19 11.16 44 55181 244272 110289802
Overdose 32.90 11.16 41 55184 233753 110300321
Liver injury 32.88 11.16 17 55208 150396 110383678
Progressive bulbar palsy 32.82 11.16 8 55217 90 110533984
Joint swelling 32.38 11.16 113 55112 442732 110091342
Stoma site dermatitis 32.19 11.16 10 55215 289 110533785
Hypervolaemia 31.92 11.16 74 55151 49386 110484688
Eructation 31.53 11.16 37 55188 14020 110520054
Hip fracture 31.32 11.16 60 55165 35091 110498983
Mental status changes 30.98 11.16 96 55129 76026 110458048
Blister 30.83 11.16 41 55184 227335 110306739
Headache 30.62 11.16 614 54611 881763 109652311
Joint range of motion decreased 29.38 11.16 12 55213 121820 110412254
Hypercholesterolaemia 29.35 11.16 5 55220 90832 110443242
Multiple sclerosis relapse 29.02 11.16 72 55153 50168 110483906
General physical health deterioration 28.81 11.16 112 55113 425183 110108891
Fluid retention 28.77 11.16 108 55117 94199 110439875
Peripheral venous disease 28.61 11.16 4 55221 84113 110449961
Gastrointestinal stoma output abnormal 28.58 11.16 10 55215 422 110533652
Hospice care 28.26 11.16 33 55192 12440 110521634
Cardiac failure congestive 27.93 11.16 149 55076 150851 110383223
Obesity 27.60 11.16 11 55214 113340 110420734
Influenza like illness 27.59 11.16 102 55123 88310 110445764
Chills 27.44 11.16 176 55049 190404 110343670
Asthma 27.43 11.16 52 55173 250239 110283835
Rheumatoid arthritis 27.27 11.16 69 55156 299544 110234530
Gastrointestinal disorder 26.75 11.16 50 55175 241902 110292172
Bursitis 26.50 11.16 16 55209 129902 110404172
Vision blurred 26.43 11.16 131 55094 128891 110405183
White blood cell count decreased 26.08 11.16 200 55025 229190 110304884
Prescribed overdose 25.83 11.16 6 55219 87575 110446499
Discomfort 24.97 11.16 43 55182 214664 110319410
Injection site erythema 24.81 11.16 103 55122 94073 110440001
Cytokine release syndrome 24.74 11.16 3 55222 70303 110463771
Grip strength decreased 24.65 11.16 5 55220 80169 110453905
Wheezing 24.63 11.16 57 55168 255173 110278901
Dyspnoea exertional 24.49 11.16 110 55115 103950 110430124
Impaired healing 24.18 11.16 38 55187 196679 110337395
Back pain 23.98 11.16 287 54938 370709 110163365
Suicide attempt 23.64 11.16 11 55214 103383 110430691
Illness 23.51 11.16 6 55219 82165 110451909
Viral infection 23.49 11.16 69 55156 53070 110481004
Pelvic pain 23.33 11.16 34 55191 15908 110518166
Urinary tract infection 23.14 11.16 257 54968 326025 110208049
Haematocrit decreased 22.96 11.16 79 55146 66038 110468036
Mobility decreased 22.93 11.16 53 55172 237369 110296705
Platelet count decreased 22.45 11.16 194 55031 230249 110303825
Pulmonary arterial hypertension 22.43 11.16 50 55175 32518 110501556
Constipation 22.34 11.16 275 54950 357511 110176563
International normalised ratio increased 22.15 11.16 94 55131 86678 110447396
Pulmonary hypertension 21.88 11.16 69 55156 55151 110478923
Blood potassium decreased 21.79 11.16 68 55157 54046 110480028
Small intestinal obstruction 21.68 11.16 49 55176 32164 110501910
Stoma site pain 21.59 11.16 13 55212 1950 110532124
Inflammation 21.30 11.16 40 55185 193198 110340876
Sleep disorder 21.13 11.16 42 55183 198602 110335472
Cellulitis 21.07 11.16 121 55104 125895 110408179
Syncope 21.05 11.16 173 55052 202363 110331711
Nasal congestion 20.99 11.16 101 55124 98181 110435893
Lung disorder 20.99 11.16 36 55189 180011 110354063
Epilepsy 20.92 11.16 12 55213 100197 110433877
Injection site pain 20.71 11.16 156 55069 177766 110356308
Myalgia 20.52 11.16 185 55040 222196 110311878
Autoimmune disorder 20.30 11.16 4 55221 65479 110468595
Oedema peripheral 20.25 11.16 252 54973 328408 110205666
Vaginal haemorrhage 20.16 11.16 41 55184 25033 110509041
Stoma site inflammation 20.14 11.16 10 55215 1025 110533049
Hypoxia 20.13 11.16 122 55103 129393 110404681
Pulmonary embolism 20.08 11.16 179 55046 214295 110319779
Gastrointestinal stoma complication 19.82 11.16 15 55210 3274 110530800
Injection site haemorrhage 19.78 11.16 48 55177 32980 110501094
Cardiac disorder 19.75 11.16 83 55142 76197 110457877
Therapeutic response decreased 19.52 11.16 12 55213 96487 110437587
Urinary tract disorder 19.52 11.16 19 55206 5825 110528249
Weight decreased 19.41 11.16 335 54890 467722 110066352
Product complaint 19.30 11.16 29 55196 13943 110520131
Liver disorder 18.92 11.16 26 55199 142217 110391857
Hot flush 18.80 11.16 74 55151 65962 110468112
Complication associated with device 18.79 11.16 35 55190 20038 110514036
Dysgeusia 18.79 11.16 77 55148 69908 110464166
Abdominal pain 18.76 11.16 360 54865 512629 110021445
Eye swelling 18.70 11.16 47 55178 33001 110501073
Hypertension 18.59 11.16 164 55061 509920 110024154
Pleural effusion 18.58 11.16 152 55073 177557 110356517
Neuropathy peripheral 18.56 11.16 153 55072 179124 110354950
Tremor 18.03 11.16 167 55058 202065 110332009
Stomatitis 17.75 11.16 72 55153 270170 110263904
Depression 17.74 11.16 239 54986 317096 110216978
Eye pain 17.51 11.16 60 55165 50039 110484035
Laryngeal pain 17.34 11.16 18 55207 5957 110528117
Atrial fibrillation 17.25 11.16 183 55042 229459 110304615
Motor neurone disease 17.14 11.16 8 55217 716 110533358
Flushing 17.14 11.16 100 55125 104636 110429438
Eosinophilia 17.02 11.16 4 55221 57932 110476142
Wound infection 16.88 11.16 14 55211 96451 110437623
Bronchitis 16.78 11.16 135 55090 156897 110377177
Hiccups 16.77 11.16 26 55199 12843 110521231
Live birth 16.50 11.16 7 55218 69477 110464597
Underweight 16.48 11.16 10 55215 1520 110532554
Lethargy 16.40 11.16 91 55134 93485 110440589
Alopecia 16.22 11.16 111 55114 364642 110169432
Condition aggravated 16.12 11.16 264 54961 734572 109799502
Gastrointestinal haemorrhage 15.94 11.16 139 55086 165379 110368695
Hepatocellular injury 15.90 11.16 3 55222 50639 110483435
Blood glucose decreased 15.72 11.16 41 55184 29447 110504627
Blood cholesterol increased 15.71 11.16 44 55181 184741 110349333
Blepharospasm 15.70 11.16 4 55221 54847 110479227
Hypersensitivity 15.56 11.16 128 55097 403870 110130204
Bone pain 15.43 11.16 69 55156 65064 110469010
Pulmonary fibrosis 15.31 11.16 17 55208 102025 110432049
Infection 15.23 11.16 112 55113 362088 110171986
Transfusion 15.23 11.16 37 55188 25435 110508639
Head discomfort 15.20 11.16 31 55194 18969 110515105
Balance disorder 15.17 11.16 105 55120 116455 110417619
Nail disorder 15.16 11.16 5 55220 57930 110476144
Atelectasis 14.66 11.16 46 55179 36666 110497408
Heavy menstrual bleeding 14.66 11.16 28 55197 16337 110517737
Cholestasis 14.54 11.16 7 55218 64511 110469563
Osteoarthritis 14.43 11.16 45 55180 182578 110351496
Interstitial lung disease 14.36 11.16 30 55195 139304 110394770
Red blood cell count decreased 14.26 11.16 68 55157 65855 110468219
Infective pulmonary exacerbation of cystic fibrosis 14.14 11.16 26 55199 14745 110519329
Bone erosion 14.03 11.16 3 55222 46368 110487706
Drug-induced liver injury 14.00 11.16 24 55201 120043 110414031
Radioisotope scan abnormal 13.99 11.16 7 55218 730 110533344
Cough 13.94 11.16 315 54910 461326 110072748
Hypersomnia 13.93 11.16 38 55187 28023 110506051
Compression fracture 13.85 11.16 20 55205 9279 110524795
Cardiac operation 13.81 11.16 16 55209 5979 110528095
Aspartate aminotransferase increased 13.71 11.16 131 55094 159805 110374269
Ocular discomfort 13.67 11.16 19 55206 8514 110525560
Mood swings 13.50 11.16 33 55192 22779 110511295
Pain in jaw 13.50 11.16 56 55169 51121 110482953
Sepsis 13.45 11.16 234 54991 327112 110206962
Hypophagia 13.42 11.16 57 55168 52569 110481505
Presyncope 13.29 11.16 54 55171 48833 110485241
Drug reaction with eosinophilia and systemic symptoms 13.07 11.16 13 55212 82082 110451992
Gallbladder disorder 13.06 11.16 31 55194 20998 110513076
Thrombosis 13.05 11.16 96 55129 108566 110425508
Application site erythema 12.97 11.16 15 55210 5595 110528479
Disease progression 12.90 11.16 182 55043 243852 110290222
Abdominal distension 12.89 11.16 139 55086 174964 110359110
Haemorrhagic stroke 12.86 11.16 24 55201 13765 110520309
Sleep disorder due to a general medical condition 12.78 11.16 5 55220 52107 110481967
Spinal fracture 12.61 11.16 32 55193 22601 110511473
Insomnia 12.48 11.16 251 54974 360339 110173735
Hepatitis 12.44 11.16 16 55209 90038 110444036
Anxiety 12.20 11.16 241 54984 344837 110189237
Cytomegalovirus infection 12.13 11.16 6 55219 54438 110479636
Decreased appetite 12.05 11.16 317 54908 475529 110058545
Accidental exposure to product 11.93 11.16 5 55220 50003 110484071
Defaecation urgency 11.86 11.16 18 55207 8729 110525345
Rotator cuff syndrome 11.81 11.16 26 55199 16768 110517306
Red blood cell sedimentation rate increased 11.79 11.16 13 55212 78289 110455785
Chest pain 11.73 11.16 258 54967 376117 110157957
Application site discolouration 11.67 11.16 7 55218 1042 110533032
Cardiac pacemaker insertion 11.57 11.16 15 55210 6286 110527788
Application site pain 11.55 11.16 14 55211 5485 110528589
Amyotrophic lateral sclerosis 11.43 11.16 9 55216 2082 110531992
Swelling face 11.33 11.16 82 55143 92239 110441835
Lumbar vertebral fracture 11.28 11.16 18 55207 9113 110524961
Hepatic function abnormal 11.21 11.16 17 55208 89278 110444796
Sciatica 11.20 11.16 18 55207 92381 110441693

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CA02 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Expectorants
ATC S01XA04 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
ATC V03AB21 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:48578 radical scavenger
CHEBI has role CHEBI:50671 antithyroid drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77035 expectorant
CHEBI has role CHEBI:228364 NMR chemical shift reference compound

Related Drugs by ATC class:

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antimony pentasulfidecineolecreosoteguaifenesinlevoverbenonesulfogaiacoltyloxapol
S01XA Other ophthalmologicals 24 drugs
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V03AB Antidotes 28 drugs
4-dimethylaminophenolacetylcysteineamyl nitriteandexanet alfaatropinecopper sulfatedimercaprolethanolflumazenilfomepizoleglutathionehydroxocobalamin show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Thyroid Gland Radiation Protection indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Lymphocutaneous sporotrichosis off-label use 87603003
Thyroid Surgery off-label use
Goiter contraindication 3716002 DOID:12176
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Multiple organ failure contraindication 57653000
Hepatic failure contraindication 59927004
Poisoning by phenobarbital contraindication 64921004
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Cystic fibrosis contraindication 190905008 DOID:1485
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Sepsis syndrome contraindication 238150007
Hypocomplementemic urticarial vasculitis contraindication 239945009
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Carbonic anhydrase 4 Enzyme Ki 4.10 CHEMBL

External reference:

IDSource
4017676 VUID
N0000146052 NUI
D01016 KEGG_DRUG
4017645 VANDF
4017676 VANDF
C0032831 UMLSCUI
CHEBI:8346 CHEBI
CHEMBL1141 ChEMBL_ID
D011193 MESH_DESCRIPTOR_UI
DB06715 DRUGBANK_ID
1C4QK22F9J UNII
4875 PUBCHEM_CID
8597 RXNORM
1847 MMSL
5333 MMSL
d00800 MMSL
000734 NDDF
000846 NDDF
003151 NDDF
007600 NDDF
400389005 SNOMEDCT_US
89351005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
POTASSIUM IODIDE HUMAN OTC DRUG LABEL 1 0178-0314 SOLUTION 65 mg ORAL ANDA 17 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 150 ug ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 150 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 150 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 150 mg ORAL Unapproved drug other 11 sections
ThyroShield HUMAN OTC DRUG LABEL 1 0256-0210 SOLUTION 65 mg ORAL ANDA 12 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 150 ug ORAL unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 150 ug ORAL unapproved drug other 14 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 12 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.20 g TOPICAL OTC monograph not final 9 sections
SSKI HUMAN PRESCRIPTION DRUG LABEL 1 17856-0114 SOLUTION 1 g ORAL unapproved drug other 18 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 150 ug ORAL unapproved drug other 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 150 ug ORAL unapproved drug other 12 sections
Strong Iodine Solution HUMAN PRESCRIPTION DRUG LABEL 2 48433-230 SOLUTION/ DROPS 1400 mg ORAL unapproved drug other 11 sections
ThyroSafe HUMAN OTC DRUG LABEL 1 50633-910 TABLET 65 mg ORAL ANDA 10 sections
ThyroSafe HUMAN OTC DRUG LABEL 1 50633-910 TABLET 65 mg ORAL ANDA 10 sections
Thyrosafe HUMAN OTC DRUG LABEL 1 50633-920 TABLET 130 mg ORAL ANDA 10 sections
NESTABSPrenatal Multi-vitamin/Mineral Supplement HUMAN PRESCRIPTION DRUG LABEL 15 50967-219 TABLET, FILM COATED 100 ug ORAL unapproved drug other 8 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-001 TABLET 130 mg ORAL NDA 16 sections
IOSAT HUMAN OTC DRUG LABEL 1 51803-002 TABLET 65 mg ORAL NDA 16 sections
Hay Fever HUMAN OTC DRUG LABEL 55 55714-2562 LIQUID 15 [hp_X] ORAL unapproved homeopathic 10 sections
BronCare HUMAN OTC DRUG LABEL 29 55714-4840 PELLET 15 [hp_X] ORAL unapproved homeopathic 10 sections
CS Bone HUMAN OTC DRUG LABEL 11 57955-0211 LIQUID 10 [hp_X] ORAL unapproved homeopathic 9 sections
Finazol HUMAN PRESCRIPTION DRUG LABEL 24 59088-008 TABLET 25 ug ORAL unapproved drug other 13 sections
Prenatol-M HUMAN PRESCRIPTION DRUG LABEL 20 59088-009 TABLET 150 ug ORAL unapproved drug other 13 sections
Vitalux HUMAN PRESCRIPTION DRUG LABEL 20 59088-139 TABLET 150 ug ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 150 ug ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 150 ug ORAL unapproved drug other 13 sections
Prometa HUMAN PRESCRIPTION DRUG LABEL 20 59088-172 TABLET 150 ug ORAL unapproved drug other 13 sections
Pretrate HUMAN PRESCRIPTION DRUG LABEL 20 59088-178 TABLET 150 ug ORAL unapproved drug other 13 sections