guaifenesin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1336 93-14-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • guaifenesin
  • glycerin guaiacolate
  • glycerol guaiacolate
  • guaifenesine
  • guaiphenesin
  • guaiphenesine
  • myocain
  • myocaine
  • myoscain
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
  • Molecular weight: 198.22
  • Formula: C10H14O4
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.92
  • ALOGS: -1.12
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.90 g O
0.90 g P

ADMET properties:

PropertyValueReference
S (Water solubility) 40.40 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 90 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1 37
kinase-selectivity-class AXL,BRAF,CDK9,ERBB2,GRK2,JAK1,MAP3K21,PDK4,PIK3CD,PRKDC,SIK2 11
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 12, 2002 FDA RECKITT BENCKISER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 521.80 9.40 259 383411 276194 89968583
Sinusitis 504.60 9.40 2818 380852 340270 89904507
Nasopharyngitis 401.35 9.40 3023 380647 404081 89840696
Toxicity to various agents 379.48 9.40 395 383275 287451 89957326
Muscle spasticity 330.51 9.40 561 383109 34761 90210016
Body temperature increased 326.79 9.40 638 383032 44072 90200705
Peripheral swelling 300.66 9.40 2867 380803 410239 89834538
Lower respiratory tract infection 293.84 9.40 1942 381728 248717 89996060
Rheumatoid arthritis 289.81 9.40 2568 381102 360046 89884731
Acute kidney injury 287.83 9.40 576 383094 319811 89924966
Blood pressure diastolic abnormal 280.11 9.40 382 383288 19499 90225278
Blood pressure fluctuation 275.06 9.40 654 383016 51759 90193018
Ear pain 271.02 9.40 690 382980 57012 90187765
Gastrointestinal disorder 252.51 9.40 1906 381764 254781 89989996
Back pain 250.66 9.40 2241 381429 314934 89929843
Pruritus 249.05 9.40 3437 380233 538088 89706689
Completed suicide 241.87 9.40 158 383512 144900 90099877
Blood pressure systolic abnormal 241.42 9.40 352 383318 19126 90225651
Blood pressure increased 239.60 9.40 1542 382128 195675 90049102
Blood pressure systolic increased 234.92 9.40 659 383011 57686 90187091
Sleep disorder due to general medical condition, insomnia type 222.34 9.40 1106 382564 127588 90117189
Food allergy 216.67 9.40 388 383282 25090 90219687
Muscle injury 213.19 9.40 1379 382291 175275 90069502
Ill-defined disorder 207.86 9.40 1418 382252 183473 90061304
Irritable bowel syndrome 204.85 9.40 1542 382128 205906 90038871
Fatigue 199.76 9.40 6337 377333 1147686 89097091
Weight increased 194.54 9.40 2659 381011 415268 89829509
Temperature regulation disorder 188.77 9.40 269 383401 14310 90230467
Contusion 188.21 9.40 1755 381915 249461 89995316
Infection 176.38 9.40 2323 381347 359771 89885006
Myelosuppression 173.94 9.40 14 383656 53577 90191200
Headache 172.06 9.40 4823 378847 857923 89386854
Neutropenia 169.74 9.40 444 383226 224460 90020317
Heart rate increased 166.62 9.40 929 382741 111973 90132804
Folliculitis 165.46 9.40 1452 382218 202901 90041876
Joint swelling 164.79 9.40 3019 380651 500281 89744496
Epilepsy 164.26 9.40 71 383599 82135 90162642
Infusion related reaction 158.42 9.40 2561 381109 414219 89830558
C-reactive protein increased 150.32 9.40 341 383329 181048 90063729
Electrocardiogram QT prolonged 140.96 9.40 65 383605 72391 90172386
Pain 140.39 9.40 5345 378325 990996 89253781
Respiratory disorder 139.28 9.40 594 383076 64222 90180555
General physical health deterioration 134.48 9.40 915 382755 354200 89890577
Oxygen saturation decreased 133.89 9.40 846 382824 106637 90138140
Blister 130.40 9.40 1651 382019 253347 89991430
Impaired healing 128.24 9.40 1536 382134 232663 90012114
Immunodeficiency 128.18 9.40 439 383231 42795 90201982
Stomatitis 123.28 9.40 1737 381933 272961 89971816
Multiple organ dysfunction syndrome 122.90 9.40 68 383602 68268 90176509
Sinus disorder 122.26 9.40 372 383298 34075 90210702
Anaemia 121.99 9.40 933 382737 351869 89892908
Arthralgia 118.30 9.40 4213 379457 774309 89470468
Cardiac failure 118.18 9.40 175 383495 109321 90135456
Pancytopenia 116.85 9.40 206 383464 120057 90124720
Hepatic cytolysis 116.58 9.40 3 383667 30913 90213864
Fluid retention 116.39 9.40 704 382966 87387 90157390
Rhabdomyolysis 114.58 9.40 37 383633 51219 90193558
Hyponatraemia 110.66 9.40 251 383419 133287 90111490
Rhinorrhoea 110.52 9.40 696 382974 87620 90157157
Agranulocytosis 108.60 9.40 11 383659 34991 90209786
Maternal exposure during pregnancy 103.55 9.40 999 382671 359064 89885713
Device expulsion 101.70 9.40 24 383646 40862 90203915
Cholestasis 99.27 9.40 17 383653 36282 90208495
Drug-induced liver injury 98.79 9.40 143 383527 90175 90154602
Hyperkalaemia 98.78 9.40 78 383592 64886 90179891
Hypersensitivity 97.69 9.40 2568 381102 452109 89792668
Blood pressure diastolic decreased 97.36 9.40 292 383378 26534 90218243
Lactic acidosis 97.03 9.40 46 383624 50417 90194360
Personality disorder 96.34 9.40 182 383488 12262 90232515
Onychomadesis 96.32 9.40 37 383633 45961 90198816
Angioedema 96.02 9.40 80 383590 64796 90179981
Drug resistance 95.97 9.40 9 383661 30440 90214337
Drug reaction with eosinophilia and systemic symptoms 95.34 9.40 31 383639 42727 90202050
Heart rate decreased 95.32 9.40 464 383206 53041 90191736
Oropharyngeal pain 94.48 9.40 821 382849 114366 90130411
Cough 93.69 9.40 2132 381538 366830 89877947
Depressed level of consciousness 93.42 9.40 102 383568 72682 90172095
Chest discomfort 90.04 9.40 939 382731 137426 90107351
Gangrene 89.55 9.40 180 383490 12696 90232081
Sinus congestion 88.89 9.40 287 383383 27137 90217640
Hepatocellular injury 87.55 9.40 10 383660 28948 90215829
Toxic epidermal necrolysis 87.28 9.40 16 383654 32512 90212265
Pyrexia 86.98 9.40 3519 380151 656966 89587811
Condition aggravated 86.53 9.40 1892 381778 593653 89651124
Sneezing 85.67 9.40 300 383370 29569 90215208
Arterial occlusive disease 85.38 9.40 173 383497 12273 90232504
Neurologic neglect syndrome 84.72 9.40 142 383528 8705 90236072
Septic shock 84.64 9.40 141 383529 84019 90160758
Seizure 84.16 9.40 346 383324 152283 90092494
Cardiac arrest 83.91 9.40 201 383469 104734 90140043
Drug abuse 83.72 9.40 137 383533 82210 90162567
Onychomycosis 83.51 9.40 27 383643 37349 90207428
Insomnia 83.41 9.40 1923 381747 331551 89913226
Carotid artery thrombosis 83.18 9.40 143 383527 8949 90235828
Dyspnoea 83.18 9.40 4540 379130 876415 89368362
Mucosal inflammation 82.92 9.40 73 383597 57552 90187225
Leukopenia 82.05 9.40 191 383479 100519 90144258
Blood pressure diastolic increased 81.05 9.40 173 383497 12733 90232044
Blepharospasm 80.07 9.40 70 383600 55375 90189402
Influenza 79.54 9.40 921 382749 138343 90106434
Illness 79.52 9.40 607 383063 81362 90163415
Bronchial secretion retention 79.50 9.40 87 383583 3528 90241249
Respiratory tract congestion 79.22 9.40 276 383394 27134 90217643
Coma 78.45 9.40 116 383554 72516 90172261
Drug ineffective 78.02 9.40 4937 378733 1379361 88865416
Hepatitis 77.36 9.40 112 383558 70627 90174150
Hypokalaemia 76.89 9.40 290 383380 130826 90113951
Bone marrow failure 76.13 9.40 21 383649 32200 90212577
Febrile neutropenia 74.77 9.40 380 383290 157969 90086808
Adjustment disorder 74.62 9.40 141 383529 9501 90235276
Night sweats 71.95 9.40 848 382822 127918 90116859
Hypotension 71.82 9.40 958 382712 324439 89920338
Injection site reaction 71.56 9.40 179 383491 91901 90152876
Hypocalcaemia 70.79 9.40 46 383624 42322 90202455
Malignant neoplasm progression 70.33 9.40 225 383445 106645 90138132
Upper respiratory tract infection 69.48 9.40 840 382830 127478 90117299
Orthostatic hypotension 69.09 9.40 46 383624 41781 90202996
Throat irritation 68.71 9.40 396 383274 48299 90196478
Suicide attempt 68.07 9.40 135 383535 75264 90169513
Serotonin syndrome 67.69 9.40 38 383632 37849 90206928
Cytomegalovirus infection 67.39 9.40 15 383655 26587 90218190
Osteonecrosis of jaw 65.96 9.40 42 383628 39061 90205716
Asthenia 65.45 9.40 2823 380847 530928 89713849
Hepatic function abnormal 64.97 9.40 60 383610 46228 90198549
Intentional self-injury 64.12 9.40 22 383648 29312 90215465
Pleural fibrosis 63.04 9.40 77 383593 3519 90241258
Sensory loss 63.02 9.40 194 383476 17881 90226896
Product use in unapproved indication 62.38 9.40 1024 382646 335212 89909565
Metabolic acidosis 62.02 9.40 87 383583 55589 90189188
Renal impairment 61.92 9.40 233 383437 105188 90139589
Product label confusion 61.83 9.40 11 383659 22839 90221938
Rash erythematous 61.41 9.40 479 383191 64625 90180152
Hypoglycaemia 61.40 9.40 127 383543 69721 90175056
Presbyacusis 61.39 9.40 70 383600 2972 90241805
Sedation 60.18 9.40 69 383601 48102 90196675
Cardio-respiratory arrest 59.66 9.40 110 383560 63030 90181747
Nasal congestion 59.51 9.40 577 383093 82837 90161940
Circulatory collapse 59.27 9.40 16 383654 24888 90219889
Scoliosis 58.97 9.40 122 383548 8785 90235992
Anxiety 57.86 9.40 1719 381951 308053 89936724
Bacterial disease carrier 57.70 9.40 54 383616 1812 90242965
Nail disorder 56.62 9.40 102 383568 58965 90185812
Urticaria 55.88 9.40 1726 381944 311008 89933769
Psoriasis 55.63 9.40 907 382763 146847 90097930
Rash maculo-papular 55.19 9.40 55 383615 40878 90203899
Gamma-glutamyltransferase increased 54.69 9.40 48 383622 37904 90206873
Pleural thickening 54.45 9.40 68 383602 3180 90241597
Affect lability 54.05 9.40 184 383486 17879 90226898
Neovascularisation 53.95 9.40 49 383621 1581 90243196
Flushing 53.58 9.40 592 383078 87899 90156878
Blood magnesium increased 53.41 9.40 69 383601 3339 90241438
Confusional state 53.34 9.40 2069 381601 384136 89860641
Generalised tonic-clonic seizure 52.94 9.40 42 383628 34861 90209916
Liver function test increased 52.17 9.40 184 383486 84671 90160106
Bradycardia 52.10 9.40 181 383489 83666 90161111
Renal failure 51.80 9.40 333 383337 130674 90114103
Asthma 51.69 9.40 1367 382303 240793 90003984
Poisoning deliberate 51.62 9.40 5 383665 16481 90228296
Creatinine renal clearance decreased 51.35 9.40 9 383661 18890 90225887
Hyperhidrosis 51.05 9.40 836 382834 135469 90109308
Skin haemorrhage 50.69 9.40 202 383468 21178 90223599
Back disorder 50.57 9.40 229 383441 25402 90219375
Therapeutic product effect decreased 50.13 9.40 1534 382136 276037 89968740
Product quality issue 50.12 9.40 170 383500 79155 90165622
Hepatotoxicity 49.71 9.40 73 383597 45769 90199008
Altered state of consciousness 49.03 9.40 37 383633 31495 90213282
Disease progression 48.65 9.40 426 383244 156189 90088588
Skin necrosis 48.44 9.40 7 383663 16934 90227843
Intentional overdose 47.87 9.40 219 383451 93615 90151162
Urine abnormality 47.77 9.40 103 383567 7634 90237143
Pancreatitis acute 47.03 9.40 40 383630 32075 90212702
Off label use 46.78 9.40 4025 379645 1098227 89146550
Prescribed overdose 46.44 9.40 624 383046 97001 90147776
Myoclonus 46.22 9.40 12 383658 19156 90225621
Systemic lupus erythematosus 45.45 9.40 1175 382495 360721 89884056
Weight decreased 45.31 9.40 2004 381666 377906 89866871
Subcutaneous drug absorption impaired 45.03 9.40 143 383527 13402 90231375
Type 2 diabetes mellitus 44.94 9.40 598 383072 202646 90042131
Eating disorder 44.76 9.40 236 383434 27837 90216940
Hemiplegia 44.36 9.40 160 383510 16000 90228777
Influenza like illness 43.75 9.40 528 383142 80083 90164694
Melaena 43.30 9.40 50 383620 34747 90210030
Foetal death 43.03 9.40 188 383482 20535 90224242
Productive cough 42.81 9.40 507 383163 76556 90168221
Premature delivery 41.76 9.40 62 383608 38700 90206077
Torsade de pointes 41.76 9.40 7 383663 15175 90229602
Thrombotic microangiopathy 41.69 9.40 8 383662 15735 90229042
Postnatal growth restriction 41.49 9.40 15 383655 69 90244708
Motor dysfunction 41.12 9.40 176 383494 19054 90225723
Cataract 40.80 9.40 476 383194 71616 90173161
Constipation 40.55 9.40 1510 382160 278885 89965892
Posterior reversible encephalopathy syndrome 40.50 9.40 22 383648 22317 90222460
Sinus operation 39.92 9.40 56 383614 2935 90241842
Pemphigus 39.52 9.40 1067 382603 325797 89918980
Lymphopenia 39.39 9.40 24 383646 22857 90221920
Nephropathy toxic 39.33 9.40 4 383666 12684 90232093
Syncope 38.95 9.40 366 383304 132297 90112480
Coordination abnormal 38.60 9.40 186 383484 21170 90223607
Aspartate aminotransferase increased 38.51 9.40 266 383404 102671 90142106
Thrombocytopenia 38.24 9.40 637 383033 208088 90036689
Superinfection 38.21 9.40 56 383614 3056 90241721
Epigastric discomfort 38.15 9.40 93 383577 7475 90237302
Osteonecrosis 38.04 9.40 33 383637 26208 90218569
Rash 37.94 9.40 3886 379784 792214 89452563
Weight fluctuation 37.88 9.40 175 383495 19574 90225203
Parkinsonism 37.56 9.40 7 383663 14058 90230719
Blood parathyroid hormone decreased 37.48 9.40 4 383666 12212 90232565
Urine leukocyte esterase positive 37.36 9.40 57 383613 3225 90241552
Inappropriate antidiuretic hormone secretion 37.16 9.40 18 383652 19487 90225290
Hypothermia 37.08 9.40 10 383660 15565 90229212
Abdominal pain upper 36.66 9.40 1741 381929 330933 89913844
Tubulointerstitial nephritis 36.58 9.40 32 383638 25311 90219466
Intentional product misuse 36.35 9.40 557 383113 89047 90155730
Alanine aminotransferase increased 35.81 9.40 324 383346 118014 90126763
Disorientation 35.65 9.40 84 383586 44030 90200747
Glossodynia 35.45 9.40 1064 382606 320715 89924062
Foetal exposure during pregnancy 35.40 9.40 81 383589 42894 90201883
Cognitive disorder 35.40 9.40 162 383508 69245 90175532
Acute respiratory distress syndrome 34.86 9.40 42 383628 28644 90216133
Transplant rejection 34.83 9.40 6 383664 12752 90232025
Abortion spontaneous 34.73 9.40 115 383555 53941 90190836
Psychotic disorder 34.58 9.40 49 383621 31181 90213596
Inflammation 34.38 9.40 540 383130 178052 90066725
General symptom 34.31 9.40 138 383532 14530 90230247
Bone cyst 33.96 9.40 46 383624 2332 90242445
Red blood cells urine positive 33.91 9.40 54 383616 3171 90241606
Cystitis 33.62 9.40 431 383239 66287 90178490
Colitis microscopic 33.37 9.40 4 383666 11155 90233622
Panniculitis 33.09 9.40 10 383660 14448 90230329
Haemophagocytic lymphohistiocytosis 33.09 9.40 12 383658 15447 90229330
Shock haemorrhagic 32.90 9.40 6 383664 12239 90232538
Pneumocystis jirovecii pneumonia 32.80 9.40 26 383644 21590 90223187
Aplastic anaemia 32.58 9.40 8 383662 13261 90231516
Neurotoxicity 32.35 9.40 26 383644 21441 90223336
Alopecia 32.25 9.40 1740 381930 493331 89751446
Rib fracture 32.23 9.40 207 383463 26228 90218549
Status epilepticus 32.21 9.40 20 383650 18854 90225923
Back injury 32.19 9.40 96 383574 46526 90198251
Hypercalcaemia 32.04 9.40 60 383610 34180 90210597
Peptic ulcer haemorrhage 31.86 9.40 31 383639 1093 90243684
Gestational hypertension 31.82 9.40 51 383619 3011 90241766
COVID-19 31.77 9.40 938 382732 167905 90076872
Feeling hot 31.67 9.40 485 383185 77523 90167254
Device dislocation 31.41 9.40 53 383617 31429 90213348
Ventricular tachycardia 31.29 9.40 35 383635 24673 90220104
Deafness neurosensory 31.27 9.40 81 383589 6760 90238017
Neutropenic sepsis 31.23 9.40 19 383651 18111 90226666
Schizophrenia 31.22 9.40 12 383658 14902 90229875
Taste disorder 31.18 9.40 144 383526 61402 90183375
Rash vesicular 31.12 9.40 156 383514 18041 90226736
Therapeutic response decreased 31.08 9.40 237 383433 89492 90155285
Chills 31.07 9.40 755 382915 131226 90113551
Hypercholesterolaemia 31.07 9.40 275 383395 100617 90144160
Polyneuropathy 30.97 9.40 22 383648 19319 90225458
Product substitution issue 30.84 9.40 19 383651 17989 90226788
Product tampering 30.76 9.40 21 383649 442 90244335
Stevens-Johnson syndrome 30.67 9.40 48 383622 29328 90215449
Poisoning 30.62 9.40 13 383657 15204 90229573
Agitation 30.54 9.40 163 383507 66935 90177842
SARS-CoV-2 test positive 30.40 9.40 110 383560 11018 90233759
Limb injury 30.36 9.40 233 383437 31275 90213502
Respiratory depression 30.25 9.40 14 383656 15561 90229216
Labelled drug-drug interaction medication error 30.08 9.40 12 383658 14570 90230207
Palpitations 30.07 9.40 775 382895 135953 90108824
Bronchopulmonary aspergillosis 29.75 9.40 6 383664 11392 90233385
Hyperglycaemia 29.70 9.40 113 383557 50857 90193920
Liver injury 29.48 9.40 526 383144 170041 90074736
Miosis 29.37 9.40 3 383667 9481 90235296
Hepatic enzyme increased 29.26 9.40 1835 381835 358901 89885876
Haemodynamic instability 28.98 9.40 7 383663 11732 90233045
Blood creatine phosphokinase increased 28.95 9.40 63 383607 33960 90210817
Akathisia 28.86 9.40 6 383664 11153 90233624
Injection site erythema 28.81 9.40 272 383398 98230 90146547
Breast cancer stage III 28.81 9.40 224 383446 84223 90160554
X-ray abnormal 28.46 9.40 306 383364 45118 90199659
Dyskinesia 28.40 9.40 71 383599 36463 90208314
Mydriasis 28.38 9.40 14 383656 14998 90229779
Tooth disorder 28.36 9.40 227 383443 30863 90213914
Drug ineffective for unapproved indication 28.11 9.40 166 383504 66478 90178299
Bursitis 28.01 9.40 743 382927 130911 90113866
Pain in extremity 27.94 9.40 2242 381428 448287 89796490
Erysipelas 27.68 9.40 3 383667 9049 90235728
Body height decreased 27.61 9.40 112 383558 11837 90232940
Stress cardiomyopathy 27.53 9.40 11 383659 13344 90231433
Neuroleptic malignant syndrome 27.17 9.40 15 383655 15081 90229696
Mobility decreased 27.13 9.40 831 382839 249903 89994874
Acute generalised exanthematous pustulosis 27.11 9.40 12 383658 13691 90231086
Granuloma skin 27.10 9.40 6 383664 10674 90234103
Macular degeneration 27.08 9.40 77 383593 37893 90206884
Adverse reaction 26.98 9.40 53 383617 29659 90215118
Jaundice cholestatic 26.82 9.40 5 383665 10038 90234739
Swollen tongue 26.70 9.40 102 383568 45854 90198923
Facet joint syndrome 26.55 9.40 277 383393 98112 90146665
Normal newborn 26.53 9.40 36 383634 23326 90221451
Blood folate decreased 26.47 9.40 34 383636 1636 90243141
Cerebral infarction 26.33 9.40 45 383625 26551 90218226
Jaundice 26.21 9.40 62 383608 32455 90212322
Rheumatic fever 26.20 9.40 473 383197 152648 90092129
Rheumatoid nodule 26.16 9.40 28 383642 20138 90224639
Transaminases increased 26.10 9.40 76 383594 37116 90207661
Drug eruption 25.85 9.40 71 383599 35336 90209441
Adrenal insufficiency 25.79 9.40 55 383615 29866 90214911
Aspergillus infection 25.67 9.40 7 383663 10816 90233961
Ear pruritus 25.59 9.40 75 383595 6728 90238049
Carbuncle 25.58 9.40 31 383639 1405 90243372
Breast cancer stage II 25.48 9.40 245 383425 35089 90209688
Drug tolerance decreased 25.32 9.40 62 383608 32068 90212709
Premature baby 25.22 9.40 42 383628 25035 90219742
Muscle rigidity 24.64 9.40 15 383655 14294 90230483
Body temperature decreased 24.58 9.40 179 383491 23637 90221140
Adulterated product 24.14 9.40 17 383653 377 90244400
Drug level increased 23.96 9.40 51 383619 27711 90217066
Shock 23.90 9.40 54 383616 28724 90216053
Product prescribing error 23.89 9.40 58 383612 30087 90214690
Seasonal allergy 23.87 9.40 173 383497 22810 90221967
Osteopenia 23.81 9.40 173 383497 22829 90221948
Injection site pain 23.67 9.40 557 383113 173142 90071635
Lupus vasculitis 23.58 9.40 20 383650 588 90244189
Cyst 23.57 9.40 135 383535 16426 90228351
Ascites 23.42 9.40 113 383557 47627 90197150
Ischaemic stroke 23.35 9.40 36 383634 22130 90222647
Hallucination, auditory 23.27 9.40 20 383650 15955 90228822
Cerebral haemorrhage 23.18 9.40 72 383598 34450 90210327
Spinal meningioma benign 23.16 9.40 11 383659 111 90244666
Left ventricular dysfunction 23.08 9.40 17 383653 14652 90230125
Hypoalbuminaemia 23.03 9.40 20 383650 15877 90228900
Therapy partial responder 23.03 9.40 36 383634 22007 90222770
Pulmonary toxicity 22.96 9.40 10 383660 11521 90233256
Pineal gland cyst 22.76 9.40 13 383657 197 90244580
Atelectasis 22.69 9.40 179 383491 24230 90220547
Cestode infection 22.68 9.40 15 383655 299 90244478
Cervicogenic headache 22.65 9.40 13 383657 199 90244578
Face oedema 22.59 9.40 40 383630 23278 90221499
Interstitial lung disease 22.33 9.40 211 383459 76194 90168583
Libido increased 22.31 9.40 32 383638 1712 90243065
Post-traumatic neck syndrome 22.29 9.40 39 383631 2475 90242302
Dermatitis bullous 22.10 9.40 8 383662 10308 90234469
Skin exfoliation 21.99 9.40 407 383263 67506 90177271
Soft tissue injury 21.96 9.40 35 383635 2057 90242720
Cardiogenic shock 21.92 9.40 44 383626 24424 90220353
Graft versus host disease 21.86 9.40 4 383666 8140 90236637
Genital haemorrhage 21.86 9.40 5 383665 8697 90236080
Pustular psoriasis 21.83 9.40 144 383526 18412 90226365
Pathogen resistance 21.75 9.40 4 383666 8111 90236666
Peritonitis 21.74 9.40 31 383639 19674 90225103
Disseminated intravascular coagulation 21.73 9.40 36 383634 21502 90223275
Oliguria 21.50 9.40 9 383661 10615 90234162
Drug withdrawal syndrome 21.42 9.40 57 383613 28666 90216111
Cytokine release syndrome 21.25 9.40 55 383615 27918 90216859
Ejection fraction decreased 21.21 9.40 50 383620 26203 90218574
Ventricular fibrillation 21.17 9.40 17 383653 14027 90230750
Hyperthyroidism 21.01 9.40 28 383642 18282 90226495
Diabetic ketoacidosis 20.93 9.40 45 383625 24362 90220415
Poor venous access 20.87 9.40 148 383522 19379 90225398
Haematemesis 20.81 9.40 73 383597 33653 90211124
Wrong technique in product usage process 20.77 9.40 198 383472 71373 90173404
Proteinuria 20.76 9.40 42 383628 23249 90221528
Disability assessment scale score increased 20.56 9.40 49 383621 3882 90240895
Epstein-Barr virus infection 20.55 9.40 9 383661 10335 90234442
Respiratory failure 20.51 9.40 365 383305 118053 90126724
Hypothyroidism 20.51 9.40 136 383534 52991 90191786
Infusion site erythema 20.49 9.40 113 383557 13557 90231220
Dry eye 20.46 9.40 352 383318 57579 90187198
Maternal exposure timing unspecified 20.42 9.40 164 383506 22319 90222458
Red cell distribution width increased 20.42 9.40 104 383566 12103 90232674
Pulmonary embolism 20.27 9.40 411 383259 130409 90114368
Monoclonal immunoglobulin present 20.21 9.40 34 383636 2090 90242687
White blood cells urine positive 20.15 9.40 67 383603 6431 90238346
Therapeutic product effect incomplete 20.15 9.40 646 383024 193250 90051527
Breast cancer female 20.07 9.40 20 383650 14866 90229911
Large intestine perforation 20.02 9.40 8 383662 9704 90235073
Haematoma 19.99 9.40 91 383579 38957 90205820
Head discomfort 19.98 9.40 128 383542 16205 90228572
Concussion 19.62 9.40 96 383574 10995 90233782
Blood calcium decreased 19.53 9.40 64 383606 30118 90214659
Metastases to liver 19.40 9.40 60 383610 28747 90216030
Gastrointestinal toxicity 19.19 9.40 8 383662 9459 90235318
Exposure to toxic agent 19.18 9.40 5 383665 7962 90236815
Suicidal ideation 19.09 9.40 210 383460 73645 90171132
Enteritis 18.95 9.40 10 383660 10311 90234466
Skin toxicity 18.93 9.40 3 383667 6776 90238001
Sputum culture positive 18.76 9.40 34 383636 2219 90242558
Accidental exposure to product 18.68 9.40 104 383566 42262 90202515
Femoral neck fracture 18.66 9.40 10 383660 10223 90234554
Acute myeloid leukaemia 18.59 9.40 37 383633 20603 90224174
Hostility 18.54 9.40 34 383636 2239 90242538
Obstruction 18.52 9.40 47 383623 3874 90240903
Vital capacity decreased 18.50 9.40 30 383640 1789 90242988
Blood bilirubin increased 18.48 9.40 108 383562 43362 90201415
Limb mass 18.48 9.40 44 383626 3484 90241293
Magnesium deficiency 18.45 9.40 19 383651 718 90244059
Cardiovascular disorder 18.33 9.40 18 383652 13474 90231303
Dystonia 18.02 9.40 27 383643 16792 90227985
Metastases to central nervous system 18.00 9.40 29 383641 17513 90227264
Hepatitis acute 17.94 9.40 12 383658 10875 90233902
Hallucination, visual 17.85 9.40 45 383625 23047 90221730
Hepatic failure 17.81 9.40 97 383573 39631 90205146
Vein collapse 17.80 9.40 23 383647 1113 90243664
Femur fracture 17.77 9.40 118 383552 45964 90198813
Obesity 17.71 9.40 327 383343 105180 90139597
Poor quality sleep 17.70 9.40 171 383499 24522 90220255
Blood cholesterol increased 17.53 9.40 711 382959 207301 90037476
Foetal growth restriction 17.35 9.40 9 383661 9371 90235406
Sternal fracture 17.33 9.40 38 383632 2849 90241928
Congenital anomaly 17.29 9.40 3 383667 6344 90238433
Sputum culture 17.26 9.40 13 383657 321 90244456
Swelling 17.18 9.40 2026 381644 417032 89827745
Drug tolerance 17.11 9.40 31 383639 17885 90226892
Urinary sediment present 17.08 9.40 32 383638 2142 90242635
Seronegative arthritis 17.02 9.40 32 383638 18202 90226575
Nerve compression 16.96 9.40 89 383581 10477 90234300
Infusion site pain 16.86 9.40 142 383528 19596 90225181
Abnormal behaviour 16.80 9.40 45 383625 22583 90222194
Myelodysplastic syndrome 16.73 9.40 40 383630 20863 90223914
Sudden death 16.71 9.40 13 383657 10896 90233881
Joint destruction 16.63 9.40 19 383651 13268 90231509
Reversible airways obstruction 16.60 9.40 30 383640 1953 90242824
Red blood cell sedimentation rate abnormal 16.59 9.40 50 383620 24154 90220623
Claustrophobia 16.47 9.40 24 383646 1303 90243474
Palmar-plantar erythrodysaesthesia syndrome 16.41 9.40 62 383608 27961 90216816
Decreased immune responsiveness 16.40 9.40 77 383593 8671 90236106
Mite allergy 16.40 9.40 19 383651 821 90243956
Injury 16.33 9.40 676 382994 196673 90048104
Eczema 16.32 9.40 144 383526 52726 90192051
Live birth 16.31 9.40 236 383434 78871 90165906
Feeling abnormal 16.28 9.40 865 382805 166370 90078407
Cerebrospinal fluid leakage 16.15 9.40 26 383644 1541 90243236
Neuralgia 16.08 9.40 204 383466 31296 90213481
Arteriovenous fistula occlusion 16.05 9.40 13 383657 358 90244419
Staphylococcal sepsis 15.93 9.40 10 383660 9373 90235404
Treatment failure 15.91 9.40 1090 382580 302838 89941939
Unintentional medical device removal 15.84 9.40 5 383665 7025 90237752
Hiatus hernia strangulated 15.80 9.40 12 383658 300 90244477
Angina pectoris 15.71 9.40 243 383427 38917 90205860
Specific gravity urine increased 15.65 9.40 11 383659 243 90244534
Peripheral sensory neuropathy 15.51 9.40 10 383660 9240 90235537
Sputum discoloured 15.51 9.40 143 383527 20248 90224529
Sepsis 15.50 9.40 613 383057 179201 90065576
Blood lactate dehydrogenase increased 15.43 9.40 57 383613 25875 90218902
Metastases to lymph nodes 15.42 9.40 16 383654 11673 90233104
No adverse event 15.39 9.40 199 383471 67783 90176994
Hypomagnesaemia 15.35 9.40 88 383582 35500 90209277
Haemodialysis 15.30 9.40 9 383661 8738 90236039
Faecaloma 15.26 9.40 13 383657 10418 90234359
Respiratory rate increased 15.24 9.40 118 383552 15883 90228894
Nephrotic syndrome 15.20 9.40 6 383664 7333 90237444
Calcification of muscle 15.14 9.40 10 383660 199 90244578
Endometrial disorder 15.08 9.40 18 383652 803 90243974
Adjustment disorder with depressed mood 15.00 9.40 330 383340 56423 90188354
Swelling face 14.98 9.40 248 383422 81104 90163673
Menstruation delayed 14.93 9.40 30 383640 2115 90242662
Blue toe syndrome 14.90 9.40 14 383656 472 90244305
Bacterial test 14.81 9.40 21 383649 1112 90243665
Diabetes mellitus inadequate control 14.76 9.40 36 383634 18648 90226129
Dissociation 14.74 9.40 5 383665 6710 90238067
Potentiating drug interaction 14.74 9.40 3 383667 5659 90239118
Oligohydramnios 14.73 9.40 6 383664 7195 90237582
Euglycaemic diabetic ketoacidosis 14.73 9.40 4 383666 6197 90238580
Hypotonia 14.67 9.40 16 383654 11410 90233367
Chronic obstructive pulmonary disease 14.66 9.40 413 383257 73416 90171361
Ileus 14.61 9.40 30 383640 16516 90228261
Blood urine present 14.60 9.40 124 383546 17154 90227623
Lower respiratory tract congestion 14.59 9.40 39 383631 3317 90241460
Dyschromatopsia 14.57 9.40 17 383653 740 90244037
Bradyphrenia 14.54 9.40 7 383663 7605 90237172
Pleural effusion 14.46 9.40 362 383308 111629 90133148
Cytomegalovirus viraemia 14.45 9.40 7 383663 7579 90237198
Myositis 14.41 9.40 161 383509 23967 90220810
Joint dislocation 14.40 9.40 120 383550 44462 90200315
Urogenital prolapse 14.38 9.40 5 383665 20 90244757
Hyperbilirubinaemia 14.33 9.40 23 383647 13913 90230864
Throat tightness 14.24 9.40 189 383481 29295 90215482
Progressive multifocal leukoencephalopathy 14.15 9.40 28 383642 15627 90229150
Multiple drug therapy 14.08 9.40 6 383664 7003 90237774
Breast cancer stage I 14.08 9.40 12 383658 9612 90235165
Eye infection viral 14.03 9.40 9 383661 170 90244607
Acute graft versus host disease 14.02 9.40 3 383667 5465 90239312
Myocarditis 14.00 9.40 23 383647 13783 90230994
Polyarthritis 14.00 9.40 36 383634 18314 90226463
Coeliac disease 13.97 9.40 266 383404 44344 90200433
Mania 13.89 9.40 24 383646 14100 90230677
Monocytosis 13.85 9.40 19 383651 975 90243802
Osteosclerosis 13.81 9.40 45 383625 4275 90240502
Hypertransaminasaemia 13.71 9.40 29 383641 15796 90228981
Creatinine urine decreased 13.70 9.40 11 383659 299 90244478
Electrocardiogram QRS complex prolonged 13.67 9.40 7 383663 7341 90237436
Hepatic enzyme 13.56 9.40 3 383667 5341 90239436
Lower limb fracture 13.55 9.40 463 383207 84550 90160227
Metamorphopsia 13.44 9.40 23 383647 1434 90243343
Diarrhoea 13.39 9.40 4305 379365 934885 89309892
Paradoxical drug reaction 13.29 9.40 54 383616 5712 90239065
Tardive dyskinesia 13.28 9.40 16 383654 10914 90233863
Feeling cold 13.24 9.40 176 383494 27289 90217488
Flashback 13.18 9.40 11 383659 316 90244461
Pregnancy 13.14 9.40 350 383320 61697 90183080
Enterocolitis 13.13 9.40 15 383655 10475 90234302
Infusion site pruritus 13.02 9.40 60 383610 6705 90238072
Middle insomnia 13.00 9.40 118 383552 16633 90228144
Hepatic encephalopathy 13.00 9.40 24 383646 13748 90231029
Subarachnoid haemorrhage 13.00 9.40 36 383634 17868 90226909
Drug dependence 12.93 9.40 72 383598 29255 90215522
Stress 12.89 9.40 443 383227 80952 90163825
Sinus headache 12.88 9.40 58 383612 6418 90238359
Asphyxia 12.87 9.40 7 383663 7096 90237681
Cushingoid 12.86 9.40 15 383655 10380 90234397
Encephalopathy 12.84 9.40 130 383540 46314 90198463
Peripheral ischaemia 12.83 9.40 4 383666 5663 90239114
Sleep disorder 12.82 9.40 989 382681 197041 90047736
Second primary malignancy 12.82 9.40 15 383655 10363 90234414
Loss of consciousness 12.76 9.40 475 383195 139763 90105014
Protein urine present 12.75 9.40 61 383609 6923 90237854
Necrosis 12.75 9.40 6 383664 6604 90238173
Infusion site extravasation 12.67 9.40 81 383589 10247 90234530
Device related infection 12.67 9.40 61 383609 25725 90219052
Staphylococcal bacteraemia 12.63 9.40 8 383662 7461 90237316
Basal cell carcinoma 12.62 9.40 86 383584 33303 90211474
Arthritis infective 12.61 9.40 67 383603 7925 90236852
Pulse abnormal 12.61 9.40 35 383635 3044 90241733
Nonspecific reaction 12.57 9.40 33 383637 2776 90242001
Device malfunction 12.55 9.40 46 383624 20931 90223846
Stillbirth 12.54 9.40 8 383662 7435 90237342
Nervous system disorder 12.49 9.40 48 383622 21545 90223232
Metastases to lung 12.49 9.40 31 383639 15960 90228817
International normalised ratio increased 12.44 9.40 134 383536 47182 90197595
Low birth weight baby 12.44 9.40 13 383657 9454 90235323
Diffuse large B-cell lymphoma 12.38 9.40 11 383659 8634 90236143
Culture urine positive 12.37 9.40 40 383630 3785 90240992
Electrolyte imbalance 12.36 9.40 55 383615 23690 90221087
Injection site haematoma 12.28 9.40 7 383663 6915 90237862
Exposure to SARS-CoV-2 12.22 9.40 30 383640 2422 90242355
Hemiparesis 12.22 9.40 196 383474 31623 90213154
Rebound effect 12.21 9.40 13 383657 9371 90235406
Bronchitis 12.20 9.40 777 382893 152150 90092627
Injection site swelling 12.17 9.40 179 383491 59660 90185117
Metastases to bone 12.15 9.40 61 383609 25444 90219333
Psoriatic arthropathy 12.09 9.40 818 382852 227517 90017260
Premenstrual syndrome 12.07 9.40 16 383654 794 90243983
Urinary casts present 12.04 9.40 7 383663 110 90244667
Pneumonia aspiration 11.99 9.40 113 383557 40827 90203950
Pyelonephritis 11.94 9.40 48 383622 21268 90223509
Skin ulcer 11.92 9.40 145 383525 49930 90194847
Multiple allergies 11.91 9.40 107 383563 15039 90229738
Muscle strain 11.90 9.40 76 383594 9611 90235166
Infusion site reaction 11.89 9.40 41 383629 18998 90225779
Tumour lysis syndrome 11.86 9.40 18 383652 11134 90233643
Full blood count decreased 11.82 9.40 184 383486 29505 90215272
Dysphagia 11.80 9.40 585 383085 111693 90133084
Hyperthermia 11.66 9.40 16 383654 10319 90234458
Heparin-induced thrombocytopenia 11.58 9.40 4 383666 5308 90239469
Psychomotor retardation 11.54 9.40 3 383667 4786 90239991
Migraine with aura 11.53 9.40 35 383635 3201 90241576
Body temperature fluctuation 11.51 9.40 28 383642 2247 90242530
Blood creatinine increased 11.45 9.40 334 383336 101052 90143725
Urine ketone body present 11.44 9.40 30 383640 2522 90242255
Clonus 11.43 9.40 5 383665 5745 90239032
Cyanosis 11.42 9.40 43 383627 19412 90225365
Salivary hypersecretion 11.38 9.40 13 383657 9079 90235698
Unresponsive to stimuli 11.26 9.40 105 383565 38016 90206761
Anaphylactic shock 11.19 9.40 83 383587 31534 90213243
Hypernatraemia 11.13 9.40 14 383656 9373 90235404
Anaphylactic reaction 11.01 9.40 284 383386 87240 90157537
Lip oedema 11.00 9.40 3 383667 4636 90240141
Abortion induced 10.97 9.40 21 383649 11867 90232910
Abnormal cord insertion 10.96 9.40 4 383666 19 90244758
Ligament sprain 10.91 9.40 102 383568 14497 90230280
Personality change 10.87 9.40 9 383661 7312 90237465
Intercepted medication error 10.81 9.40 16 383654 881 90243896
Ileus paralytic 10.80 9.40 4 383666 5081 90239696
Premature rupture of membranes 10.79 9.40 5 383665 5553 90239224
Gastrointestinal haemorrhage 10.78 9.40 295 383375 89953 90154824
Device difficult to use 10.77 9.40 38 383632 17487 90227290
Hand-foot-and-mouth disease 10.76 9.40 12 383658 497 90244280
Allergy to immunoglobulin therapy 10.71 9.40 8 383662 195 90244582
Atypical femur fracture 10.69 9.40 7 383663 6414 90238363
Partial seizures 10.68 9.40 9 383661 7251 90237526
Hypothalamo-pituitary disorder 10.64 9.40 27 383643 2225 90242552
Lichen sclerosus 10.63 9.40 20 383650 1343 90243434
Hypogammaglobulinaemia 10.62 9.40 18 383652 10656 90234121
White coat hypertension 10.55 9.40 17 383653 1008 90243769
Stupor 10.53 9.40 5 383665 5477 90239300
Human papilloma virus test positive 10.51 9.40 14 383656 698 90244079
Flail chest 10.50 9.40 6 383664 91 90244686
Thymoma 10.49 9.40 9 383661 269 90244508
Mycobacterial disease carrier 10.48 9.40 4 383666 22 90244755
Upper-airway cough syndrome 10.45 9.40 104 383566 15031 90229746
Cholangitis 10.45 9.40 9 383661 7173 90237604
Dysgeusia 10.43 9.40 294 383376 52266 90192511
Drug dose omission by device 10.41 9.40 17 383653 10214 90234563
Hallucinations, mixed 10.39 9.40 6 383664 5883 90238894
Drug use disorder 10.37 9.40 12 383658 8331 90236446
Coagulopathy 10.36 9.40 57 383613 23232 90221545
Systemic candida 10.36 9.40 4 383666 4955 90239822
Hyperadrenalism 10.34 9.40 4 383666 23 90244754
Hyperuricaemia 10.30 9.40 8 383662 6711 90238066
Lip swelling 10.29 9.40 109 383561 38501 90206276
Toxic encephalopathy 10.29 9.40 13 383657 8686 90236091
Uterine leiomyoma 10.28 9.40 80 383590 10784 90233993
Injection site pruritus 10.28 9.40 163 383507 53671 90191106
Hot flush 10.25 9.40 327 383343 59161 90185616
Arthritis 10.24 9.40 832 382838 166483 90078294
Overweight 10.24 9.40 51 383619 5883 90238894
Renal pain 10.24 9.40 62 383608 7697 90237080
Macular oedema 10.19 9.40 4 383666 4905 90239872
Hypertriglyceridaemia 10.18 9.40 11 383659 7878 90236899
Enthesopathy 10.17 9.40 15 383655 9389 90235388
Respiratory arrest 10.16 9.40 91 383579 33220 90211557
Disease recurrence 10.16 9.40 106 383564 37547 90207230
Pemphigoid 10.16 9.40 14 383656 9012 90235765
Thoracic operation 10.15 9.40 7 383663 150 90244627
Cranial nerve decompression 10.14 9.40 3 383667 6 90244771
Lung perforation 10.11 9.40 6 383664 98 90244679
Influenza virus test positive 10.11 9.40 7 383663 151 90244626
Escherichia infection 10.08 9.40 34 383636 15861 90228916
Benign abdominal neoplasm 10.04 9.40 8 383662 215 90244562
Renal tubular necrosis 10.03 9.40 30 383640 14525 90230252
Gastrooesophageal reflux disease 10.00 9.40 589 383081 165748 90079029
Hypertensive crisis 9.99 9.40 40 383630 17744 90227033
Candida infection 9.97 9.40 94 383576 33963 90210814
Ulcer 9.96 9.40 90 383580 32792 90211985
Pulmonary tuberculosis 9.94 9.40 4 383666 4830 90239947
Musculoskeletal discomfort 9.91 9.40 134 383536 20857 90223920
Inappropriate schedule of product administration 9.90 9.40 750 382920 149183 90095594
Overlap syndrome 9.88 9.40 13 383657 8535 90236242
Migraine without aura 9.88 9.40 14 383656 741 90244036
Increased tendency to bruise 9.87 9.40 85 383585 11805 90232972
Ventricular arrhythmia 9.87 9.40 3 383667 4318 90240459
Restlessness 9.87 9.40 100 383570 35620 90209157
Myocardial ischaemia 9.86 9.40 28 383642 13786 90230991
Demyelination 9.80 9.40 12 383658 8128 90236649
Lactose intolerance 9.80 9.40 34 383636 3335 90241442
Atrioventricular block first degree 9.78 9.40 13 383657 8498 90236279
Congestive cardiomyopathy 9.78 9.40 10 383660 7344 90237433
Blood urea increased 9.76 9.40 82 383588 30331 90214446
Sarcoidosis 9.73 9.40 19 383651 10654 90234123
Dermatitis allergic 9.72 9.40 39 383631 17288 90227489
Liver function test abnormal 9.69 9.40 154 383516 50691 90194086
Hyperpyrexia 9.69 9.40 4 383666 4757 90240020
Acute pulmonary oedema 9.68 9.40 16 383654 9564 90235213
Failed induction of labour 9.67 9.40 11 383659 466 90244311
Uterine haemorrhage 9.66 9.40 4 383666 4748 90240029
Rheumatoid factor positive 9.58 9.40 612 383058 171038 90073739
Therapeutic response shortened 9.57 9.40 143 383527 22736 90222041
Haematuria 9.57 9.40 98 383572 34839 90209938
Hyperammonaemia 9.56 9.40 8 383662 6467 90238310
Prescribed underdose 9.55 9.40 243 383427 74776 90170001
Pulmonary contusion 9.49 9.40 5 383665 64 90244713
Lip pruritus 9.44 9.40 19 383651 1341 90243436

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 365.40 10.78 618 114679 60188 42445850
Drug interaction 270.53 10.78 197 115100 266802 42239236
Blood pressure diastolic abnormal 192.65 10.78 148 115149 5980 42500058
Fatigue 189.72 10.78 1903 113394 433738 42072300
Blood pressure increased 180.32 10.78 646 114651 101282 42404756
Heart rate decreased 166.95 10.78 330 114967 36202 42469836
Blood pressure systolic increased 154.44 10.78 274 115023 27694 42478344
Chills 151.95 10.78 579 114718 93487 42412551
Blood pressure systolic abnormal 149.09 10.78 122 115175 5406 42500632
Toxicity to various agents 141.63 10.78 252 115045 228884 42277154
Back pain 136.44 10.78 749 114548 141027 42365011
Arthralgia 133.42 10.78 981 114316 204257 42301781
Blood pressure fluctuation 120.44 10.78 241 115056 26667 42479371
Cough 114.95 10.78 850 114447 177253 42328785
Acute kidney injury 103.26 10.78 578 114719 366759 42139279
Multiple organ dysfunction syndrome 102.81 10.78 68 115229 96967 42409071
Hyperhidrosis 92.29 10.78 486 114811 90026 42416012
Oxygen saturation decreased 85.99 10.78 375 114922 64312 42441726
General physical health deterioration 82.40 10.78 179 115118 151067 42354971
Nephrolithiasis 80.65 10.78 251 115046 36579 42469459
Postnatal growth restriction 75.23 10.78 26 115271 174 42505864
Cardiac failure 72.92 10.78 110 115187 106746 42399292
Myelosuppression 70.97 10.78 12 115285 40449 42465589
Pain in extremity 69.52 10.78 667 114630 149937 42356101
Pain 66.32 10.78 979 114318 243869 42262169
Weight decreased 65.43 10.78 854 114443 207094 42298944
Headache 64.79 10.78 957 114340 238412 42267626
Thrombocytopenia 63.88 10.78 281 115016 189998 42316040
Renal impairment 63.77 10.78 126 115171 110102 42395936
Sinusitis 63.48 10.78 275 115022 47017 42459021
Nausea 63.47 10.78 1461 113836 395338 42110700
Flushing 63.10 10.78 232 115065 36796 42469242
Rhabdomyolysis 62.79 10.78 71 115226 77948 42428090
Nightmare 61.89 10.78 178 115119 24834 42481204
Cholestasis 61.70 10.78 8 115289 32871 42473167
Drug reaction with eosinophilia and systemic symptoms 60.85 10.78 19 115278 42056 42463982
Drug resistance 60.41 10.78 10 115287 34238 42471800
Heart rate increased 59.88 10.78 294 115003 52961 42453077
Neutropenia 58.52 10.78 309 114988 199122 42306916
Blood pressure diastolic increased 56.69 10.78 78 115219 6327 42499711
Hyperkalaemia 54.71 10.78 83 115214 80375 42425663
Nasopharyngitis 54.71 10.78 402 114895 83594 42422444
Throat irritation 53.88 10.78 113 115184 12923 42493115
Chest discomfort 53.19 10.78 324 114973 63292 42442746
C-reactive protein increased 52.06 10.78 57 115240 63503 42442535
Neck pain 51.93 10.78 189 115108 29825 42476213
Peripheral swelling 50.47 10.78 417 114880 89853 42416185
Rheumatoid arthritis 50.38 10.78 238 115059 42202 42463836
Sedation 49.47 10.78 188 115109 30287 42475751
Completed suicide 49.39 10.78 118 115179 96347 42409691
Urticaria 49.16 10.78 356 114941 73680 42432358
Rhinorrhoea 49.05 10.78 193 115104 31601 42474437
Agranulocytosis 47.65 10.78 12 115285 30600 42475438
Coma 47.30 10.78 45 115252 53509 42452529
Joint swelling 45.11 10.78 327 114970 67695 42438343
Pancytopenia 43.14 10.78 168 115129 117575 42388463
Septic shock 42.42 10.78 118 115179 91554 42414484
Drug ineffective 42.25 10.78 1342 113955 628855 41877183
Vitamin D deficiency 41.88 10.78 77 115220 7996 42498042
Condition aggravated 41.21 10.78 479 114818 260275 42245763
Lactic acidosis 41.19 10.78 37 115260 45224 42460814
Leukopenia 41.05 10.78 88 115209 74658 42431380
Cytomegalovirus infection 40.97 10.78 18 115279 32288 42473750
Altered state of consciousness 40.92 10.78 14 115283 29245 42476793
Pulmonary function test decreased 40.84 10.78 63 115234 5669 42500369
Weight increased 40.21 10.78 458 114839 107525 42398513
Febrile neutropenia 40.02 10.78 316 114981 185387 42320651
Blood pressure diastolic decreased 37.27 10.78 85 115212 10290 42495748
Hypoglycaemia 36.73 10.78 66 115231 59788 42446250
Bone marrow failure 36.67 10.78 22 115275 33071 42472967
Product used for unknown indication 35.56 10.78 28 115269 1173 42504865
Interstitial lung disease 35.56 10.78 102 115195 78360 42427678
Hepatic function abnormal 35.24 10.78 53 115244 51514 42454524
Tubulointerstitial nephritis 34.92 10.78 21 115276 31527 42474511
Muscle spasms 33.87 10.78 369 114928 85675 42420363
Rash 33.70 10.78 984 114313 275970 42230068
Pancreatitis acute 33.57 10.78 25 115272 33539 42472499
Dyspnoea 33.32 10.78 1489 113808 441132 42064906
Body temperature decreased 33.19 10.78 100 115197 14313 42491725
Gamma-glutamyltransferase increased 32.77 10.78 24 115273 32473 42473565
Sleep disorder due to general medical condition, insomnia type 32.62 10.78 29 115268 1440 42504598
Mucosal inflammation 32.54 10.78 52 115245 49322 42456716
Eosinophilia 32.27 10.78 25 115272 32874 42473164
Oropharyngeal pain 32.11 10.78 211 115086 42299 42463739
Drug ineffective for unapproved indication 31.98 10.78 47 115250 46116 42459922
Musculoskeletal stiffness 31.82 10.78 266 115031 57499 42448539
Bone pain 31.64 10.78 138 115159 23654 42482384
Abdominal discomfort 31.61 10.78 327 114970 74928 42431110
Circulatory collapse 30.24 10.78 13 115284 23623 42482415
Bronchitis 30.20 10.78 225 115072 46976 42459062
Lymphocyte count 29.64 10.78 14 115283 226 42505812
Nephropathy toxic 29.51 10.78 5 115292 16833 42489205
Hospice care 28.67 10.78 68 115229 8445 42497593
Cerebral infarction 27.74 10.78 26 115271 31143 42474895
Osteoarthritis 27.61 10.78 135 115162 24270 42481768
Post concussion syndrome 27.07 10.78 12 115285 166 42505872
Cardiogenic shock 26.99 10.78 34 115263 35606 42470432
Illness 26.85 10.78 136 115161 24794 42481244
Renal failure 26.74 10.78 254 115043 143472 42362566
Asthenia 26.72 10.78 969 114328 279824 42226214
Treatment failure 26.51 10.78 84 115213 62540 42443498
Bradycardia 26.42 10.78 130 115167 85354 42420684
Melaena 26.30 10.78 40 115257 38706 42467332
Fall 26.29 10.78 825 114472 233695 42272343
Pneumonia 26.24 10.78 1394 113903 420755 42085283
Miosis 25.89 10.78 3 115294 13443 42492595
Pruritus 25.82 10.78 681 114616 188090 42317948
Chest pain 25.77 10.78 525 114772 139005 42367033
Poor venous access 25.59 10.78 59 115238 7193 42498845
Ascites 25.44 10.78 74 115223 56604 42449434
Toxic epidermal necrolysis 25.39 10.78 21 115276 26729 42479309
Maternal exposure before pregnancy 25.39 10.78 22 115275 1055 42504983
Metabolic acidosis 25.31 10.78 65 115232 51793 42454245
Anaemia 25.16 10.78 572 114725 279706 42226332
Influenza 25.09 10.78 268 115029 61907 42444131
Hyponatraemia 25.05 10.78 166 115131 101296 42404742
Dental caries 24.68 10.78 46 115251 4826 42501212
Contusion 24.55 10.78 196 115101 41789 42464249
Extrapyramidal disorder 24.47 10.78 7 115290 16405 42489633
Throat tightness 24.41 10.78 69 115228 9530 42496508
Constipation 24.41 10.78 593 114704 161698 42344340
Pharyngeal paraesthesia 24.38 10.78 20 115277 889 42505149
Epilepsy 24.29 10.78 21 115276 26150 42479888
Pneumocystis jirovecii pneumonia 23.62 10.78 20 115277 25161 42480877
Mobility decreased 22.98 10.78 169 115128 35137 42470901
Labelled drug-drug interaction medication error 22.59 10.78 7 115290 15575 42490463
Pleural thickening 22.53 10.78 15 115282 482 42505556
Dizziness 22.45 10.78 855 114442 248399 42257639
Productive cough 22.09 10.78 225 115072 51342 42454696
Infusion site extravasation 22.06 10.78 47 115250 5434 42500604
Infusion site pruritus 21.86 10.78 21 115276 1152 42504886
Hypoaesthesia 21.79 10.78 292 115005 71171 42434867
Neutropenic sepsis 21.66 10.78 8 115289 15938 42490100
Osteonecrosis 21.48 10.78 8 115289 15857 42490181
Lymphocyte count abnormal 21.45 10.78 28 115269 2159 42503879
Electrocardiogram QT prolonged 21.23 10.78 63 115234 47882 42458156
Therapy partial responder 21.23 10.78 14 115283 20007 42486031
Feeling hot 21.16 10.78 122 115175 23360 42482678
Dyspepsia 20.97 10.78 187 115110 41165 42464873
Red blood cell count decreased 20.95 10.78 156 115141 32559 42473479
Therapy non-responder 20.92 10.78 74 115223 53285 42452753
Nasal congestion 20.82 10.78 144 115153 29357 42476681
Rash maculo-papular 20.71 10.78 44 115253 37459 42468579
Urinary tract infection 20.50 10.78 380 114917 98904 42407134
Type IIa hyperlipidaemia 20.49 10.78 12 115285 306 42505732
Delirium 20.48 10.78 73 115224 52446 42453592
Cerebral haemorrhage 20.46 10.78 47 115250 38919 42467119
Overdose 20.45 10.78 184 115113 105080 42400958
Hyperphosphataemia 20.43 10.78 5 115292 12999 42493039
Hip fracture 20.15 10.78 81 115216 13391 42492647
Acute respiratory failure 19.85 10.78 176 115121 38682 42467356
Depressed level of consciousness 19.85 10.78 65 115232 47905 42458133
Hypocalcaemia 19.67 10.78 32 115265 30141 42475897
Drug eruption 19.67 10.78 20 115277 23055 42482983
Death 19.40 10.78 1502 113795 469683 42036355
Diabetes mellitus 19.36 10.78 90 115207 59997 42446041
Ischaemic stroke 19.26 10.78 19 115278 22214 42483824
Vein disorder 19.21 10.78 26 115271 2076 42503962
Aplastic anaemia 18.99 10.78 5 115292 12379 42493659
Progressive multifocal leukoencephalopathy 18.99 10.78 4 115293 11532 42494506
Parkinsonism 18.96 10.78 3 115294 10620 42495418
Feeling abnormal 18.80 10.78 279 115018 69507 42436531
Failure to thrive 18.61 10.78 62 115235 9360 42496678
Graft versus host disease 18.39 10.78 6 115291 12919 42493119
Ill-defined disorder 18.33 10.78 90 115207 16206 42489832
Anaphylactic shock 18.26 10.78 22 115275 23495 42482543
Drug use disorder 18.26 10.78 3 115294 10330 42495708
Cytomegalovirus infection reactivation 18.15 10.78 4 115293 11174 42494864
Respiratory symptom 17.98 10.78 4 115293 11102 42494936
C-reactive protein decreased 17.97 10.78 26 115271 2210 42503828
Body temperature increased 17.84 10.78 105 115192 20253 42485785
Respiratory rate increased 17.75 10.78 68 115229 10994 42495044
Haematotoxicity 17.70 10.78 4 115293 10981 42495057
Drug hypersensitivity 17.70 10.78 372 114925 99017 42407021
Pulmonary alveolar haemorrhage 17.64 10.78 9 115288 14807 42491231
Hot flush 17.52 10.78 112 115185 22239 42483799
Product use issue 17.35 10.78 298 114999 76453 42429585
Aspergillus infection 16.89 10.78 11 115286 15826 42490212
Pathogen resistance 16.86 10.78 5 115292 11445 42494593
Dry throat 16.75 10.78 29 115268 2873 42503165
Posterior reversible encephalopathy syndrome 16.48 10.78 7 115290 12814 42493224
Blood creatine phosphokinase increased 16.42 10.78 71 115226 48267 42457771
Loss of personal independence in daily activities 16.42 10.78 74 115223 49742 42456296
Arthritis 16.36 10.78 180 115117 41885 42464153
Psychotic disorder 16.35 10.78 34 115263 29174 42476864
Weight fluctuation 16.34 10.78 44 115253 5907 42500131
Appendicitis 16.31 10.78 19 115278 20594 42485444
Cystitis bacterial 16.20 10.78 9 115288 207 42505831
Peritonitis 16.05 10.78 16 115281 18617 42487421
Insomnia 15.97 10.78 426 114871 117827 42388211
Poisoning 15.96 10.78 10 115287 14689 42491349
Upper-airway cough syndrome 15.94 10.78 36 115261 4330 42501708
Nervous system neoplasm 15.86 10.78 8 115289 150 42505888
Pemphigus 15.64 10.78 23 115274 1983 42504055
Arthropathy 15.61 10.78 135 115162 29462 42476576
Joint effusion 15.59 10.78 43 115254 5854 42500184
Liver disorder 15.53 10.78 55 115242 39589 42466449
Hand fracture 15.43 10.78 28 115269 2878 42503160
Generalised tonic-clonic seizure 15.37 10.78 30 115267 26349 42479689
Localised infection 15.30 10.78 101 115196 20272 42485766
Gait disturbance 15.30 10.78 360 114937 97640 42408398
Tooth infection 15.19 10.78 52 115245 7959 42498079
Shock haemorrhagic 15.11 10.78 13 115284 16229 42489809
Drug level increased 15.09 10.78 30 115267 26170 42479868
Hepatitis cholestatic 15.00 10.78 4 115293 9820 42496218
Increased tendency to bruise 14.81 10.78 35 115262 4335 42501703
Haematocrit decreased 14.80 10.78 152 115145 34756 42471282
Skin discolouration 14.76 10.78 102 115195 20788 42485250
Plasma cell myeloma 14.74 10.78 195 115102 47383 42458655
Paraesthesia ear 14.66 10.78 5 115292 32 42506006
Haemarthrosis 14.63 10.78 33 115264 3965 42502073
Musculoskeletal pain 14.53 10.78 146 115151 33194 42472844
Hypokalaemia 14.53 10.78 124 115173 71597 42434441
Hypomagnesaemia 14.45 10.78 35 115262 28453 42477585
Penile torsion 14.40 10.78 4 115293 11 42506027
Foot fracture 14.30 10.78 43 115254 6148 42499890
Inappropriate schedule of product administration 14.27 10.78 350 114947 95552 42410486
Chronic obstructive pulmonary disease 14.24 10.78 245 115052 62869 42443169
Jaundice 14.22 10.78 47 115250 34542 42471496
Nonreassuring foetal heart rate pattern 14.15 10.78 5 115292 36 42506002
Paraesthesia 14.08 10.78 278 115019 73181 42432857
Hyperthyroidism 13.93 10.78 11 115286 14330 42491708
Lymphopenia 13.93 10.78 23 115274 21540 42484498
Discomfort 13.81 10.78 116 115181 25103 42480935
Rib fracture 13.59 10.78 84 115213 16487 42489551
Low birth weight baby 13.51 10.78 5 115292 9950 42496088
Hepatotoxicity 13.50 10.78 30 115267 25137 42480901
Angioedema 13.46 10.78 64 115233 42413 42463625
Flatulence 13.41 10.78 115 115182 25037 42481001
Abdominal pain upper 13.37 10.78 305 114992 82304 42423734
Tooth disorder 13.36 10.78 66 115231 11913 42494125
Vitello-intestinal duct remnant 13.34 10.78 7 115290 143 42505895
Sinus disorder 13.34 10.78 50 115247 8000 42498038
Snapping hip syndrome 13.27 10.78 4 115293 16 42506022
Hepatocellular carcinoma 13.17 10.78 3 115294 8191 42497847
Carbon dioxide decreased 13.13 10.78 22 115275 2122 42503916
Joint stiffness 13.11 10.78 67 115230 12255 42493783
Gynaecomastia 13.04 10.78 9 115288 12558 42493480
Hypogammaglobulinaemia 13.04 10.78 8 115289 11883 42494155
Purpura 13.01 10.78 8 115289 11871 42494167
Urethral meatus stenosis 13.00 10.78 5 115292 47 42505991
Paranasal sinus hypersecretion 12.97 10.78 16 115281 1165 42504873
Blood phosphorus increased 12.95 10.78 9 115288 12516 42493522
Disability assessment scale score increased 12.93 10.78 10 115287 408 42505630
Hypophosphataemia 12.93 10.78 23 115274 20922 42485116
Gastrooesophageal reflux disease 12.92 10.78 182 115115 44841 42461197
Cytomegalovirus viraemia 12.82 10.78 6 115291 10371 42495667
Musculoskeletal chest pain 12.69 10.78 62 115235 11142 42494896
Myasthenia gravis 12.63 10.78 15 115282 16122 42489916
Aggression 12.60 10.78 69 115228 44094 42461944
Anion gap abnormal 12.54 10.78 10 115287 427 42505611
Dry skin 12.53 10.78 192 115105 48146 42457892
Ear infection 12.51 10.78 68 115229 12736 42493302
Kidney transplant rejection 12.41 10.78 4 115293 8679 42497359
Hypertension 12.39 10.78 562 114735 166642 42339396
Inappropriate antidiuretic hormone secretion 12.30 10.78 16 115281 16525 42489513
Pemphigoid 12.18 10.78 8 115289 11459 42494579
Oliguria 12.11 10.78 5 115292 9308 42496730
Sinus congestion 12.11 10.78 44 115253 6936 42499102
Cholangitis 12.07 10.78 7 115290 10720 42495318
Cardio-respiratory arrest 12.04 10.78 101 115196 58535 42447503
Neuroleptic malignant syndrome 12.01 10.78 25 115272 21447 42484591
Neurological symptom 12.00 10.78 6 115291 9985 42496053
Thymic cancer metastatic 11.99 10.78 5 115292 59 42505979
Appendix disorder 11.98 10.78 12 115285 693 42505345
Arthritis infective 11.93 10.78 31 115266 4075 42501963
Haemodynamic instability 11.74 10.78 10 115287 12547 42493491
Hypoxia 11.71 10.78 259 115038 69527 42436511
Myocarditis 11.51 10.78 21 115276 18917 42487121
Normochromic normocytic anaemia 11.50 10.78 5 115292 9026 42497012
Arrhythmia 11.50 10.78 63 115234 40254 42465784
Red blood cell spherocytes present 11.47 10.78 3 115294 6 42506032
Epstein-Barr virus infection 11.43 10.78 6 115291 9712 42496326
Feeling cold 11.43 10.78 67 115230 12906 42493132
Bronchopulmonary aspergillosis 11.40 10.78 22 115275 19407 42486631
Red cell distribution width increased 11.33 10.78 43 115254 6921 42499117
Intercepted product preparation error 11.30 10.78 3 115294 7386 42498652
Therapeutic product effect incomplete 11.29 10.78 130 115167 70809 42435229
Irregular sleep phase 11.24 10.78 6 115291 127 42505911
Bronchial wall thickening 11.20 10.78 16 115281 1344 42504694
Bladder cancer 11.18 10.78 18 115279 17029 42489009
Bile output abnormal 11.18 10.78 4 115293 30 42506008
Haematochezia 11.15 10.78 221 115076 58215 42447823
Synovial cyst 11.11 10.78 23 115274 2606 42503432
Ear pain 11.08 10.78 40 115257 6286 42499752
Medication error 11.07 10.78 49 115248 33105 42472933
Ventricular fibrillation 11.01 10.78 43 115254 30080 42475958
Acute respiratory distress syndrome 10.99 10.78 43 115254 30065 42475973
White blood cell count decreased 10.96 10.78 383 114914 110013 42396025
Congestive cardiomyopathy 10.93 10.78 5 115292 8759 42497279
Blood calcium decreased 10.86 10.78 59 115238 11049 42494989
Hypertriglyceridaemia 10.84 10.78 7 115290 10119 42495919
Musculoskeletal disorder 10.81 10.78 41 115256 6597 42499441

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 864.54 9.92 379 406364 499804 109682752
Toxicity to various agents 554.18 9.92 570 406173 479985 109702571
Rheumatoid arthritis 513.22 9.92 2323 404420 297290 109885266
Sinusitis 480.55 9.92 2263 404480 294425 109888131
Blood pressure diastolic abnormal 464.55 9.92 523 406220 25292 110157264
Infusion related reaction 463.79 9.92 2685 404058 378477 109804079
Acute kidney injury 452.23 9.92 1046 405697 634384 109548172
Blood pressure increased 423.62 9.92 1978 404765 256395 109926161
Nasopharyngitis 416.46 9.92 2678 404065 391683 109790873
Blood pressure fluctuation 412.78 9.92 875 405868 73949 110108607
Blood pressure systolic increased 395.21 9.92 915 405828 82076 110100480
Blood pressure systolic abnormal 389.57 9.92 469 406274 24381 110158175
Fatigue 360.93 9.92 6373 400370 1209585 108972971
Back pain 303.67 9.92 2369 404374 368627 109813929
Completed suicide 295.87 9.92 273 406470 242108 109940448
Pain 275.56 9.92 4985 401758 949970 109232586
Peripheral swelling 265.66 9.92 2457 404286 401577 109780979
Neutropenia 260.26 9.92 624 406119 373996 109808560
Myelosuppression 256.35 9.92 25 406718 94315 110088241
Multiple organ dysfunction syndrome 253.80 9.92 120 406623 151590 110030966
Heart rate increased 249.52 9.92 1120 405623 142714 110039842
Muscle spasticity 246.17 9.92 460 406283 35455 110147101
Arthralgia 244.80 9.92 4126 402617 775506 109407050
Heart rate decreased 241.91 9.92 762 405981 81994 110100562
Contusion 240.05 9.92 1575 405168 231786 109950770
Headache 236.98 9.92 4556 402187 877821 109304735
Body temperature increased 221.75 9.92 567 406176 54146 110128410
Weight increased 217.79 9.92 2431 404312 417213 109765343
Oxygen saturation decreased 216.72 9.92 1145 405598 155837 110026719
Ear pain 210.98 9.92 547 406196 52679 110129877
Sleep disorder due to general medical condition, insomnia type 203.42 9.92 849 405894 104794 110077762
Joint swelling 201.30 9.92 2501 404242 440344 109742212
Pruritus 196.10 9.92 3115 403628 578445 109604111
Gastrointestinal disorder 191.72 9.92 1534 405209 240418 109942138
Rhabdomyolysis 191.22 9.92 102 406641 120299 110062257
Cardiac failure 189.55 9.92 247 406496 187379 109995177
Pancytopenia 188.07 9.92 300 406443 209313 109973243
Temperature regulation disorder 187.97 9.92 234 406509 12592 110169964
Anaemia 184.51 9.92 1216 405527 545870 109636686
Hepatic cytolysis 182.83 9.92 4 406739 55049 110127507
Drug reaction with eosinophilia and systemic symptoms 179.16 9.92 41 406702 82054 110100502
Hyperkalaemia 172.81 9.92 147 406596 135649 110046907
Cholestasis 167.88 9.92 20 406723 64498 110118058
Food allergy 163.10 9.92 276 406467 19672 110162884
Rhinorrhoea 162.21 9.92 778 405965 101888 110080668
Epilepsy 161.93 9.92 83 406660 100126 110082430
Agranulocytosis 158.61 9.92 20 406723 61740 110120816
Irritable bowel syndrome 158.39 9.92 1091 405652 163124 110019432
Muscle injury 156.86 9.92 970 405773 139837 110042719
General physical health deterioration 153.25 9.92 926 405817 424369 109758187
Drug resistance 152.99 9.92 15 406728 56359 110126197
Lower respiratory tract infection 151.40 9.92 1462 405281 241644 109940912
Cough 150.71 9.92 2460 404283 459181 109723375
Blood pressure diastolic decreased 149.70 9.92 376 406367 35509 110147047
Septic shock 148.46 9.92 218 406525 157310 110025246
Ill-defined disorder 147.69 9.92 1036 405707 155817 110026739
Lactic acidosis 145.37 9.92 80 406663 92731 110089825
Renal impairment 144.60 9.92 297 406446 188148 109994408
C-reactive protein increased 144.18 9.92 372 406371 217547 109965009
Hepatocellular injury 144.18 9.92 11 406732 50631 110131925
Hyponatraemia 140.61 9.92 376 406367 217277 109965279
Chest discomfort 140.27 9.92 1107 405636 172741 110009815
Electrocardiogram QT prolonged 139.80 9.92 117 406626 108843 110073713
Thrombocytopenia 136.22 9.92 740 406003 348145 109834411
Blood pressure diastolic increased 135.32 9.92 246 406497 18561 110163995
Febrile neutropenia 131.45 9.92 658 406085 316109 109866447
Oropharyngeal pain 130.00 9.92 898 405845 134378 110048178
Coma 129.82 9.92 145 406598 117724 110064832
Sinus disorder 129.34 9.92 336 406407 32392 110150164
Mucosal inflammation 127.38 9.92 100 406643 96041 110086515
Cytomegalovirus infection 123.26 9.92 25 406718 54419 110128137
Influenza 116.85 9.92 1040 405703 168061 110014495
Bone marrow failure 116.45 9.92 34 406709 57814 110124742
Depressed level of consciousness 116.29 9.92 145 406598 112133 110070423
Leukopenia 116.28 9.92 232 406511 148559 110033997
Personality disorder 114.89 9.92 185 406558 12652 110169904
Folliculitis 112.22 9.92 1024 405719 166629 110015927
Hypersensitivity 111.41 9.92 2096 404647 401902 109780654
Sneezing 109.04 9.92 311 406432 31673 110150883
Illness 109.03 9.92 593 406150 81578 110100978
Throat irritation 108.29 9.92 437 406306 53115 110129441
Toxic epidermal necrolysis 107.68 9.92 37 406706 56690 110125866
Hepatic function abnormal 107.22 9.92 102 406641 89193 110093363
Angioedema 105.40 9.92 124 406619 98376 110084180
Sinus congestion 103.67 9.92 296 406447 30163 110152393
Altered state of consciousness 103.63 9.92 41 406702 57585 110124971
Pain in extremity 101.50 9.92 2426 404317 484692 109697864
Blister 101.36 9.92 1280 405463 226096 109956460
Flushing 101.05 9.92 696 406047 104040 110078516
Cardiac arrest 100.32 9.92 378 406365 196375 109986181
Carotid artery thrombosis 98.98 9.92 148 406595 9490 110173066
Neurologic neglect syndrome 98.68 9.92 145 406598 9153 110173403
Fluid retention 97.17 9.92 637 406106 93670 110088886
Discomfort 96.69 9.92 1211 405532 213496 109969060
Impaired healing 96.19 9.92 1127 405616 195590 109986966
Circulatory collapse 94.75 9.92 21 406722 42972 110139584
Respiratory tract congestion 94.66 9.92 289 406454 30568 110151988
Renal failure 94.33 9.92 470 406273 226104 109956452
Bradycardia 93.52 9.92 278 406465 155239 110027317
Hypoglycaemia 93.34 9.92 178 406565 115926 110066630
Anxiety 93.28 9.92 1785 404958 343293 109839263
Weight decreased 92.67 9.92 2315 404428 465742 109716814
Immunodeficiency 91.74 9.92 333 406410 38505 110144051
Arterial occlusive disease 91.40 9.92 185 406558 15123 110167433
Metabolic acidosis 91.09 9.92 141 406602 99603 110082953
Chills 90.61 9.92 1086 405657 189494 109993062
Infection 89.34 9.92 1848 404895 360352 109822204
Pancreatitis acute 88.67 9.92 56 406687 60218 110122338
Hyperhidrosis 88.48 9.92 1066 405677 186232 109996324
Toxic skin eruption 87.66 9.92 3 406740 27512 110155044
Rash maculo-papular 85.40 9.92 88 406655 74134 110108422
Adjustment disorder 85.14 9.92 147 406596 10648 110171908
Hypokalaemia 83.89 9.92 365 406378 182083 110000473
Gamma-glutamyltransferase increased 82.19 9.92 63 406680 61246 110121310
Gangrene 82.00 9.92 184 406559 16157 110166399
Tubulointerstitial nephritis 81.85 9.92 49 406694 54235 110128321
Onychomadesis 81.27 9.92 33 406710 45630 110136926
Melaena 80.85 9.92 80 406663 68677 110113879
Hypocalcaemia 80.44 9.92 73 406670 65293 110117263
Cardio-respiratory arrest 80.28 9.92 193 406550 115643 110066913
Drug-induced liver injury 79.35 9.92 205 406538 119862 110062694
Respiratory disorder 77.74 9.92 489 406254 70893 110111663
Poisoning deliberate 77.04 9.92 5 406738 26326 110156230
Disease progression 76.87 9.92 553 406190 243481 109939075
Pleural thickening 75.49 9.92 77 406666 3322 110179234
Urticaria 75.09 9.92 1616 405127 317241 109865315
Insomnia 74.78 9.92 1795 404948 358795 109823761
Hypotension 74.62 9.92 1417 405326 522432 109660124
Nasal congestion 74.45 9.92 617 406126 97665 110084891
Scoliosis 74.28 9.92 123 406620 8610 110173946
Hepatitis 74.21 9.92 136 406607 89918 110092638
Condition aggravated 73.29 9.92 2100 404643 732736 109449820
Drug ineffective for unapproved indication 71.54 9.92 171 406572 102667 110079889
Nephropathy toxic 70.31 9.92 9 406734 27469 110155087
Affect lability 69.24 9.92 187 406556 18450 110164106
Sensory loss 68.68 9.92 204 406539 21253 110161303
Pleural fibrosis 68.65 9.92 82 406661 4226 110178330
Hepatic enzyme increased 67.63 9.92 1601 405142 319291 109863265
Presbyacusis 66.53 9.92 66 406677 2753 110179803
Upper respiratory tract infection 66.24 9.92 757 405986 130571 110051985
Seizure 65.95 9.92 509 406234 220676 109961880
Hepatotoxicity 65.51 9.92 82 406661 63318 110119238
Influenza like illness 65.35 9.92 552 406191 87860 110094696
Product use in unapproved indication 65.29 9.92 1205 405538 446172 109736384
Orthostatic hypotension 65.06 9.92 89 406654 66160 110116396
Bronchial secretion retention 64.73 9.92 86 406657 4938 110177618
Interstitial lung disease 64.51 9.92 278 406465 139056 110043500
Dyspnoea 64.02 9.92 4810 401933 1102062 109080494
Cerebral infarction 63.66 9.92 58 406685 51780 110130776
Onychomycosis 63.62 9.92 31 406712 38500 110144056
Ascites 63.23 9.92 156 406587 92652 110089904
Osteonecrosis of jaw 62.28 9.92 51 406692 47966 110134590
Miosis 61.94 9.92 5 406738 21978 110160578
Haematotoxicity 61.69 9.92 4 406739 21078 110161478
Posterior reversible encephalopathy syndrome 61.03 9.92 24 406719 33837 110148719
Bacterial disease carrier 60.87 9.92 57 406686 2212 110180344
Feeling hot 60.70 9.92 556 406187 90550 110092006
Generalised tonic-clonic seizure 60.49 9.92 67 406676 54613 110127943
Intentional self-injury 60.46 9.92 31 406712 37398 110145158
Neovascularisation 59.27 9.92 50 406693 1687 110180869
Overdose 58.55 9.92 563 406180 233231 109949325
Cystitis 58.55 9.92 430 406313 65606 110116950
Suicide attempt 58.49 9.92 190 406553 103204 110079352
Therapy partial responder 57.95 9.92 32 406711 37029 110145527
Drug abuse 57.83 9.92 398 406345 177013 110005543
Labelled drug-drug interaction medication error 57.57 9.92 18 406725 29284 110153272
Night sweats 57.45 9.92 749 405994 133234 110049322
Parkinsonism 57.42 9.92 7 406736 22180 110160376
Cardiogenic shock 57.35 9.92 76 406667 57262 110125294
Pneumocystis jirovecii pneumonia 57.17 9.92 44 406699 42691 110139865
Eating disorder 57.04 9.92 245 406498 30613 110151943
Jaundice 56.75 9.92 81 406662 59155 110123401
Inappropriate antidiuretic hormone secretion 56.25 9.92 27 406716 33824 110148732
Psoriasis 55.66 9.92 772 405971 139221 110043335
Lymphopenia 55.49 9.92 40 406703 40130 110142426
Shock haemorrhagic 54.87 9.92 16 406727 27231 110155325
Skin haemorrhage 54.57 9.92 208 406535 24619 110157937
Torsade de pointes 54.12 9.92 9 406734 22591 110159965
Device expulsion 53.89 9.92 23 406720 30868 110151688
Stomatitis 53.81 9.92 1338 405405 268904 109913652
Cataract 53.41 9.92 486 406257 78999 110103557
Aplastic anaemia 53.31 9.92 12 406731 24296 110158260
Productive cough 53.27 9.92 649 406094 113656 110068900
Blood magnesium increased 53.24 9.92 68 406675 3755 110178801
Blood creatine phosphokinase increased 52.85 9.92 119 406624 72958 110109598
Skin necrosis 52.79 9.92 8 406735 21504 110161052
Off label use 52.34 9.92 4780 401963 1495405 108687151
Product label confusion 52.20 9.92 10 406733 22667 110159889
Cytomegalovirus infection reactivation 52.13 9.92 4 406739 18329 110164227
Foetal death 51.78 9.92 153 406590 15892 110166664
Blepharospasm 51.57 9.92 76 406667 54775 110127781
Creatinine renal clearance decreased 51.55 9.92 9 406734 21806 110160750
Body temperature decreased 51.33 9.92 270 406473 36665 110145891
Psychotic disorder 50.45 9.92 68 406675 50869 110131687
Neutropenic sepsis 50.36 9.92 25 406718 30721 110151835
Bursitis 50.26 9.92 713 406030 129205 110053351
Poisoning 50.25 9.92 22 406721 29083 110153473
Asthma 50.06 9.92 1240 405503 249051 109933505
Cardiotoxicity 50.00 9.92 3 406740 16878 110165678
Prescribed overdose 49.77 9.92 517 406226 87064 110095492
Thrombotic microangiopathy 48.81 9.92 23 406720 29126 110153430
Haemodynamic instability 48.81 9.92 12 406731 22876 110159680
Urine abnormality 48.56 9.92 105 406638 8991 110173565
Graft versus host disease 48.50 9.92 6 406737 18800 110163756
Cerebral haemorrhage 48.46 9.92 104 406639 64864 110117692
Rash 48.44 9.92 3574 403169 817390 109365166
Abdominal discomfort 48.38 9.92 1838 404905 392020 109790536
Weight fluctuation 48.23 9.92 185 406558 21960 110160596
Drug eruption 47.90 9.92 77 406666 53582 110128974
Malignant neoplasm progression 47.78 9.92 411 406332 174156 110008400
Poor venous access 47.12 9.92 197 406546 24325 110158231
Drug level increased 46.96 9.92 64 406679 47655 110134901
Status epilepticus 46.89 9.92 29 406714 31542 110151014
Acute respiratory distress syndrome 46.87 9.92 77 406666 53121 110129435
Injection site reaction 46.77 9.92 169 406574 88901 110093655
Aspergillus infection 46.43 9.92 18 406725 25598 110156958
Bronchopulmonary aspergillosis 46.38 9.92 26 406717 29837 110152719
Osteonecrosis 46.09 9.92 34 406709 33707 110148849
Drug ineffective 46.03 9.92 4895 401848 1515645 108666911
Rib fracture 45.66 9.92 245 406498 33525 110149031
Arthritis 45.60 9.92 868 405875 166718 110015838
Ischaemic stroke 45.16 9.92 51 406692 41212 110141344
Asthenia 45.04 9.92 3025 403718 685974 109496582
Hepatitis cholestatic 44.35 9.92 6 406737 17560 110164996
Ventricular fibrillation 44.20 9.92 52 406691 41261 110141295
Venoocclusive liver disease 44.16 9.92 3 406740 15204 110167352
Coordination abnormal 44.12 9.92 197 406546 25031 110157525
Nephrolithiasis 43.55 9.92 403 406340 65809 110116747
Arthropathy 43.10 9.92 1373 405370 286149 109896407
Hyperglycaemia 43.01 9.92 164 406579 84926 110097630
Motor dysfunction 43.00 9.92 191 406552 24215 110158341
Intentional overdose 42.81 9.92 298 406445 132203 110050353
Palpitations 42.08 9.92 821 405922 158391 110024165
Disorientation 41.99 9.92 127 406616 70544 110112012
Neuroleptic malignant syndrome 41.95 9.92 38 406705 34021 110148535
Helicobacter infection 40.94 9.92 916 405827 180961 110001595
Nausea 40.86 9.92 5164 401579 1230526 108952030
Nail disorder 40.56 9.92 96 406647 57839 110124717
Myoclonus 40.42 9.92 37 406706 32961 110149595
Cyst 40.28 9.92 143 406600 16353 110166203
Pathogen resistance 40.24 9.92 8 406735 17664 110164892
Transplant rejection 40.20 9.92 20 406723 24547 110158009
Ventricular tachycardia 39.90 9.92 77 406666 49932 110132624
Eosinophilia 39.77 9.92 97 406646 57839 110124717
Syncope 39.16 9.92 517 406226 202019 109980537
Haemophagocytic lymphohistiocytosis 39.12 9.92 35 406708 31524 110151032
Cognitive disorder 39.05 9.92 177 406566 87334 110095222
Therapeutic product effect decreased 38.82 9.92 1175 405568 243141 109939415
Urine leukocyte esterase positive 38.68 9.92 58 406685 3728 110178828
Respiratory failure 38.65 9.92 558 406185 214774 109967782
Stevens-Johnson syndrome 38.49 9.92 71 406672 46830 110135726
Hepatic failure 38.40 9.92 127 406616 68612 110113944
Musculoskeletal stiffness 38.29 9.92 1322 405421 278500 109904056
Epstein-Barr virus infection 37.74 9.92 11 406732 18727 110163829
Serotonin syndrome 37.56 9.92 103 406640 59050 110123506
Oliguria 37.49 9.92 11 406732 18646 110163910
Lower limb fracture 37.39 9.92 433 406310 74915 110107641
Erysipelas 37.06 9.92 3 406740 13155 110169401
Limb injury 36.82 9.92 251 406492 37385 110145171
Hyperthyroidism 36.82 9.92 32 406711 29229 110153327
Sinus operation 36.71 9.92 50 406693 2941 110179615
Acute graft versus host disease 36.10 9.92 3 406740 12878 110169678
Hypomagnesaemia 35.50 9.92 109 406634 60261 110122295
Transaminases increased 35.49 9.92 117 406626 63273 110119283
Feeling abnormal 35.44 9.92 893 405850 179818 110002738
Disseminated intravascular coagulation 35.23 9.92 61 406682 41225 110141331
Red cell distribution width increased 35.07 9.92 143 406600 17459 110165097
SARS-CoV-2 test positive 34.87 9.92 139 406604 16796 110165760
Sepsis 34.72 9.92 927 405816 326419 109856137
Polyneuropathy 34.56 9.92 40 406703 31972 110150584
Tooth disorder 34.55 9.92 206 406537 29303 110153253
Akathisia 34.55 9.92 10 406733 17103 110165453
Neurotoxicity 34.54 9.92 64 406679 42143 110140413
BK virus infection 34.25 9.92 4 406739 13102 110169454
Blood parathyroid hormone decreased 34.19 9.92 4 406739 13085 110169471
Pregnancy 34.18 9.92 312 406431 50755 110131801
Hypothermia 34.03 9.92 28 406715 26274 110156282
Hypoalbuminaemia 33.73 9.92 34 406709 28940 110153616
Pulmonary alveolar haemorrhage 33.59 9.92 16 406727 20134 110162422
Dry eye 33.44 9.92 333 406410 55460 110127096
Alanine aminotransferase increased 33.41 9.92 475 406268 183298 109999258
Body height decreased 33.40 9.92 100 406643 10463 110172093
Ear pruritus 33.40 9.92 79 406664 7181 110175375
Hemiplegia 33.37 9.92 169 406574 22613 110159943
Swelling 33.15 9.92 1594 405149 349447 109833109
Hallucination, auditory 33.05 9.92 29 406714 26368 110156188
Gait disturbance 32.88 9.92 1293 405450 276915 109905641
Chest pain 32.84 9.92 1696 405047 374679 109807877
Peritonitis 32.83 9.92 43 406700 32564 110149992
Colitis microscopic 32.83 9.92 5 406738 13389 110169167
Product tampering 32.81 9.92 21 406722 458 110182098
Osteoarthritis 32.79 9.92 892 405851 181731 110000825
Dystonia 32.74 9.92 28 406715 25777 110156779
Joint stiffness 32.73 9.92 385 406358 66858 110115698
Aspartate aminotransferase increased 32.49 9.92 404 406339 159532 110023024
Haematemesis 32.47 9.92 110 406633 58998 110123558
Stress cardiomyopathy 32.35 9.92 9 406734 15797 110166759
Skin toxicity 32.33 9.92 3 406740 11780 110170776
Maternal exposure timing unspecified 32.28 9.92 158 406585 20855 110161701
Contraindicated product administered 32.25 9.92 1166 405577 247101 109935455
Infusion site pain 31.97 9.92 138 406605 17281 110165275
Hallucination, visual 31.58 9.92 61 406682 39544 110143012
Cytomegalovirus viraemia 31.35 9.92 13 406730 17751 110164805
Shock 31.34 9.92 97 406646 53491 110129065
Schizophrenia 31.12 9.92 21 406722 21805 110160751
Bronchitis 31.09 9.92 777 405966 156255 110026301
Disability assessment scale score increased 30.90 9.92 56 406687 4214 110178342
Cytokine release syndrome 30.89 9.92 143 406600 70163 110112393
Abdominal pain upper 30.83 9.92 1575 405168 347536 109835020
Diabetic ketoacidosis 30.81 9.92 68 406675 41990 110140566
Osteopenia 30.62 9.92 162 406581 22047 110160509
Progressive multifocal leukoencephalopathy 30.55 9.92 28 406715 24928 110157628
Jaundice cholestatic 30.49 9.92 8 406735 14600 110167956
COVID-19 30.39 9.92 1145 405598 243915 109938641
Infusion site extravasation 30.27 9.92 103 406640 11531 110171025
Subarachnoid haemorrhage 30.08 9.92 39 406704 29663 110152893
Hepatic encephalopathy 29.77 9.92 36 406707 28220 110154336
Dyskinesia 29.47 9.92 94 406649 51352 110131204
Muscle rigidity 29.37 9.92 27 406716 24004 110158552
Constipation 29.36 9.92 1603 405140 356183 109826373
Potentiating drug interaction 29.34 9.92 4 406739 11639 110170917
Hypothyroidism 29.30 9.92 153 406590 72746 110109810
Acute myocardial infarction 29.28 9.92 184 406559 83593 110098963
Drug use disorder 29.15 9.92 15 406728 18059 110164497
Epigastric discomfort 29.13 9.92 86 406657 8929 110173627
Superinfection 29.04 9.92 65 406678 5698 110176858
Exposure to toxic agent 28.91 9.92 6 406737 12852 110169704
Myocarditis 28.88 9.92 41 406702 30014 110152542
Agitation 28.81 9.92 271 406472 112780 110069776
Limb mass 28.66 9.92 52 406691 3917 110178639
Anti-cyclic citrullinated peptide antibody positive 28.57 9.92 874 405869 181110 110001446
Throat tightness 28.51 9.92 216 406527 33273 110149283
Acute myeloid leukaemia 28.43 9.92 61 406682 38049 110144507
Kidney transplant rejection 28.21 9.92 5 406738 11982 110170574
Panniculitis 28.16 9.92 11 406732 15571 110166985
Infusion site pruritus 28.11 9.92 59 406684 4949 110177607
Rash erythematous 28.09 9.92 440 406303 81392 110101164
Face oedema 28.06 9.92 50 406693 33419 110149137
Duodenal ulcer perforation 28.05 9.92 854 405889 176846 110005710
Myelodysplastic syndrome 27.96 9.92 60 406683 37424 110145132
Hypercalcaemia 27.61 9.92 84 406659 46573 110135983
Swollen tongue 27.58 9.92 121 406622 60241 110122315
Asphyxia 27.45 9.92 9 406734 14206 110168350
Hyperphosphataemia 27.32 9.92 13 406730 16368 110166188
Product prescribing error 27.21 9.92 97 406646 51234 110131322
Cholangitis 27.18 9.92 13 406730 16322 110166234
Haematuria 27.14 9.92 186 406557 82819 110099737
Blood creatinine increased 27.14 9.92 491 406252 182398 110000158
X-ray abnormal 27.12 9.92 236 406507 37881 110144675
Dermatitis exfoliative generalised 27.11 9.92 4 406739 10968 110171588
Blood folate decreased 27.10 9.92 38 406705 2297 110180259
Infusion site erythema 26.95 9.92 101 406642 11858 110170698
Anaphylactic shock 26.93 9.92 98 406645 51448 110131108
Product substitution issue 26.92 9.92 27 406716 23034 110159522
Immune reconstitution inflammatory syndrome 26.87 9.92 13 406730 16213 110166343
Carbuncle 26.87 9.92 30 406713 1437 110181119
Post-traumatic neck syndrome 26.86 9.92 40 406703 2555 110180001
Left ventricular dysfunction 26.86 9.92 28 406715 23465 110159091
Hepatitis acute 26.83 9.92 18 406725 18748 110163808
Cystitis haemorrhagic 26.83 9.92 6 406737 12203 110170353
Tumour lysis syndrome 26.75 9.92 45 406698 30756 110151800
Hypogammaglobulinaemia 26.44 9.92 21 406722 20055 110162501
Eczema 26.19 9.92 157 406586 72136 110110420
Dermatitis bullous 26.18 9.92 16 406727 17513 110165043
Granuloma skin 25.92 9.92 5 406738 11278 110171278
Adjustment disorder with depressed mood 25.86 9.92 261 406482 43622 110138934
Pulmonary embolism 25.81 9.92 596 406147 213878 109968678
Pemphigoid 25.47 9.92 21 406722 19686 110162870
Coma scale abnormal 25.34 9.92 3 406740 9723 110172833
Pineal gland cyst 25.31 9.92 14 406729 231 110182325
Immunosuppressant drug level increased 25.29 9.92 6 406737 11718 110170838
Inappropriate schedule of product administration 25.13 9.92 951 405792 202686 109979870
Drug withdrawal syndrome 25.11 9.92 65 406678 37989 110144567
Nerve compression 25.05 9.92 94 406649 11043 110171513
Cestode infection 24.88 9.92 15 406728 293 110182263
Acute coronary syndrome 24.82 9.92 29 406714 23083 110159473
Hyperthermia 24.72 9.92 25 406718 21247 110161309
Sternal fracture 24.65 9.92 44 406699 3272 110179284
Hot flush 24.57 9.92 360 406383 65676 110116880
Proteinuria 24.43 9.92 71 406672 39947 110142609
Encephalopathy 24.39 9.92 186 406557 80869 110101687
Respiratory rate increased 24.37 9.92 167 406576 24916 110157640
Congestive cardiomyopathy 24.15 9.92 11 406732 14208 110168348
Deafness neurosensory 24.02 9.92 84 406659 9535 110173021
Concussion 24.00 9.92 95 406648 11443 110171113
Catatonia 23.95 9.92 6 406737 11294 110171262
Product quality issue 23.92 9.92 176 406567 77123 110105433
Hypercholesterolaemia 23.90 9.92 216 406527 90621 110091935
Adrenal insufficiency 23.90 9.92 78 406665 42312 110140244
Lupus vasculitis 23.62 9.92 19 406724 599 110181957
White blood cells urine positive 23.57 9.92 71 406672 7453 110175103
Soft tissue injury 23.44 9.92 35 406708 2241 110180315
Arthritis infective 23.44 9.92 88 406655 10341 110172215
Rheumatoid nodule 23.42 9.92 24 406719 20272 110162284
Red blood cells urine positive 23.40 9.92 56 406687 5129 110177427
Cervicogenic headache 23.31 9.92 13 406730 218 110182338
Wrong technique in product usage process 23.29 9.92 207 406536 87141 110095415
Colorectal cancer 23.28 9.92 3 406740 9111 110173445
Adverse reaction 23.23 9.92 46 406697 29548 110153008
Hypophosphataemia 23.21 9.92 55 406688 33127 110149429
Coeliac disease 23.16 9.92 252 406491 42935 110139621
Gastric cancer 23.03 9.92 6 406737 11002 110171554
Renal injury 22.90 9.92 21 406722 18692 110163864
Enteritis 22.85 9.92 22 406721 19134 110163422
Spinal meningioma benign 22.84 9.92 10 406733 96 110182460
Pulmonary toxicity 22.82 9.92 19 406724 17727 110164829
Graft versus host disease in gastrointestinal tract 22.79 9.92 3 406740 8965 110173591
Urinary tract infection 22.79 9.92 1441 405302 324841 109857715
Poor quality sleep 22.74 9.92 179 406564 27898 110154658
Arrhythmia 22.70 9.92 156 406587 69419 110113137
Therapeutic product effect incomplete 22.63 9.92 638 406105 223167 109959389
Back disorder 22.57 9.92 143 406600 20779 110161777
Appendicitis 22.55 9.92 44 406699 28420 110154136
Ejection fraction decreased 22.51 9.92 76 406667 40804 110141752
Calcification of muscle 22.41 9.92 12 406731 185 110182371
Clostridium difficile colitis 22.37 9.92 84 406659 43694 110138862
Type IIa hyperlipidaemia 22.29 9.92 17 406726 495 110182061
Pulse abnormal 22.27 9.92 48 406695 4101 110178455
Upper-airway cough syndrome 22.09 9.92 116 406627 15741 110166815
Bone cyst 22.06 9.92 44 406699 3559 110178997
Blood lactate dehydrogenase increased 22.05 9.92 86 406657 44248 110138308
Sputum discoloured 22.00 9.92 177 406566 27768 110154788
Atelectasis 21.94 9.92 219 406524 36493 110146063
Suicidal ideation 21.93 9.92 230 406513 93707 110088849
Feeling cold 21.92 9.92 206 406537 33781 110148775
Normal newborn 21.92 9.92 29 406714 21867 110160689
Monoclonal immunoglobulin present 21.91 9.92 36 406707 2504 110180052
Mucormycosis 21.85 9.92 6 406737 10622 110171934
Liver function test increased 21.83 9.92 214 406529 88334 110094222
Drug dependence 21.82 9.92 102 406641 49918 110132638
Respiratory depression 21.63 9.92 54 406689 31947 110150609
Gastrointestinal toxicity 21.63 9.92 7 406736 11141 110171415
Muscle spasms 21.59 9.92 1240 405503 276917 109905639
Blood urine present 21.56 9.92 158 406585 24087 110158469
Prostate cancer 21.40 9.92 69 406674 37572 110144984
Breast cancer stage II 21.34 9.92 173 406570 27202 110155354
Gastrointestinal haemorrhage 21.33 9.92 455 406288 165063 110017493
Leukoencephalopathy 21.28 9.92 4 406739 9191 110173365
Adenovirus infection 21.16 9.92 7 406736 10987 110171569
Nervous system disorder 21.07 9.92 54 406689 31667 110150889
Oesophageal carcinoma 21.05 9.92 8 406735 11516 110171040
Platelet count decreased 21.05 9.92 666 406077 229777 109952779
Musculoskeletal pain 21.00 9.92 848 405895 182175 110000381
Exostosis 21.00 9.92 260 406483 45696 110136860
Wound 20.96 9.92 1059 405684 233378 109949178
Nightmare 20.94 9.92 227 406516 38636 110143920
Failure to thrive 20.80 9.92 102 406641 13472 110169084
Body temperature fluctuation 20.65 9.92 44 406699 3729 110178827
Osteosclerosis 20.63 9.92 49 406694 4466 110178090
Dental caries 20.31 9.92 97 406646 12676 110169880
Eosinophilic granulomatosis with polyangiitis 20.23 9.92 7 406736 10679 110171877
Bladder cancer 20.18 9.92 27 406716 20265 110162291
Nephrotic syndrome 20.14 9.92 13 406730 13818 110168738
Enterocolitis 20.11 9.92 24 406719 18925 110163631
Ileus paralytic 20.06 9.92 9 406734 11728 110170828
Cardiovascular disorder 20.00 9.92 33 406710 22727 110159829
Intestinal ischaemia 19.99 9.92 18 406725 16161 110166395
Hypertriglyceridaemia 19.92 9.92 18 406725 16136 110166420
Decreased immune responsiveness 19.90 9.92 79 406664 9527 110173029
Autoimmune disorder 19.85 9.92 345 406398 65138 110117418
Gestational hypertension 19.72 9.92 32 406711 2202 110180354
Death 19.54 9.92 2261 404482 696608 109485948
Klebsiella infection 19.52 9.92 27 406716 19982 110162574
Urinary sediment present 19.38 9.92 34 406709 2494 110180062
Uterine leiomyoma 19.38 9.92 68 406675 7732 110174824
Post concussion syndrome 19.30 9.92 18 406725 695 110181861
Arteriovenous fistula occlusion 19.14 9.92 16 406727 533 110182023
Pulmonary tuberculosis 19.09 9.92 5 406738 9134 110173422
Hostility 19.06 9.92 35 406708 2661 110179895
Second primary malignancy 19.05 9.92 23 406720 18045 110164511
Pharyngeal paraesthesia 19.05 9.92 45 406698 4087 110178469
Hyperbilirubinaemia 19.03 9.92 54 406689 30617 110151939
Ear infection 18.83 9.92 330 406413 62402 110120154
Large intestine perforation 18.81 9.92 20 406723 16609 110165947
Tooth infection 18.75 9.92 143 406600 22073 110160483
Vital capacity decreased 18.72 9.92 30 406713 2043 110180513
Alcohol poisoning 18.71 9.92 5 406738 9015 110173541
Infusion site swelling 18.70 9.92 79 406664 9798 110172758
Staphylococcal sepsis 18.64 9.92 22 406721 17432 110165124
Acute pulmonary oedema 18.61 9.92 21 406722 16975 110165581
Blood bilirubin increased 18.56 9.92 184 406559 75788 110106768
Hyperammonaemia 18.55 9.92 14 406729 13718 110168838
Product used for unknown indication 18.54 9.92 29 406714 1934 110180622
Bradyphrenia 18.52 9.92 10 406733 11718 110170838
Pneumonia aspiration 18.51 9.92 200 406543 81033 110101523
Pulmonary function test decreased 18.39 9.92 72 406671 8628 110173928
Gynaecomastia 18.34 9.92 6 406737 9484 110173072
Palmar-plantar erythrodysaesthesia syndrome 18.29 9.92 83 406660 40942 110141614
Musculoskeletal chest pain 18.18 9.92 174 406569 28673 110153883
Diffuse large B-cell lymphoma 18.12 9.92 19 406724 15879 110166677
Peripheral ischaemia 18.10 9.92 9 406734 11049 110171507
Candida infection 18.06 9.92 103 406640 47906 110134650
Disease recurrence 18.04 9.92 140 406603 60644 110121912
Hypertransaminasaemia 17.94 9.92 39 406704 24216 110158340
Drug intolerance 17.91 9.92 1732 405011 404780 109777776
Postnatal growth restriction 17.89 9.92 6 406737 25 110182531
Hip fracture 17.88 9.92 203 406540 34948 110147608
Endometrial disorder 17.83 9.92 17 406726 675 110181881
Premenstrual syndrome 17.77 9.92 16 406727 590 110181966
Renal tubular disorder 17.70 9.92 3 406740 7426 110175130
Haematoma 17.68 9.92 134 406609 58342 110124214
Hyperpyrexia 17.66 9.92 4 406739 8065 110174491
Ulcer 17.61 9.92 90 406653 43026 110139530
Dry throat 17.58 9.92 74 406669 9164 110173392
Partial seizures 17.45 9.92 10 406733 11339 110171217
Ligament sprain 17.44 9.92 110 406633 15958 110166598
Hiatus hernia strangulated 17.32 9.92 12 406731 300 110182256
Claustrophobia 17.30 9.92 25 406718 1554 110181002
Sputum culture 17.25 9.92 12 406731 302 110182254
Seasonal allergy 17.24 9.92 128 406615 19594 110162962
Cerebral haematoma 17.08 9.92 7 406736 9625 110172931
Electrolyte imbalance 17.06 9.92 74 406669 36954 110145602
Accidental overdose 17.02 9.92 116 406627 51718 110130838
Skin discolouration 16.94 9.92 264 406479 48782 110133774
Tardive dyskinesia 16.90 9.92 15 406728 13564 110168992
Premature delivery 16.83 9.92 57 406686 30575 110151981
Faecaloma 16.78 9.92 18 406725 14890 110167666
Libido increased 16.75 9.92 32 406711 2507 110180049
Cytomegalovirus chorioretinitis 16.71 9.92 3 406740 7125 110175431
Lower respiratory tract congestion 16.70 9.92 47 406696 4749 110177807
Subcutaneous drug absorption impaired 16.69 9.92 64 406679 7595 110174961
Protein urine present 16.68 9.92 85 406658 11399 110171157
Electrocardiogram QRS complex prolonged 16.67 9.92 14 406729 13007 110169549
Hand deformity 16.55 9.92 972 405771 217534 109965022
Myocardial ischaemia 16.54 9.92 47 406696 26637 110155919
Systemic candida 16.50 9.92 8 406735 9966 110172590
Cytomegalovirus colitis 16.50 9.92 3 406740 7058 110175498
Psychomotor skills impaired 16.49 9.92 3 406740 7055 110175501
Bacterial test 16.32 9.92 21 406722 1168 110181388
Visual acuity reduced 16.26 9.92 62 406681 32111 110150445
Skin exfoliation 16.26 9.92 430 406313 87221 110095335
Menstruation delayed 16.25 9.92 26 406717 1768 110180788
Necrosis 16.23 9.92 11 406732 11395 110171161
Erectile dysfunction 16.21 9.92 27 406716 18529 110164027
Lip oedema 16.18 9.92 4 406739 7596 110174960
Carbon dioxide decreased 16.16 9.92 46 406697 4678 110177878
Wrist deformity 16.10 9.92 36 406707 3153 110179403
Hypersensitivity vasculitis 16.09 9.92 3 406740 6934 110175622
Blue toe syndrome 16.04 9.92 16 406727 672 110181884
Hepatosplenomegaly 16.03 9.92 3 406740 6916 110175640
Magnesium deficiency 16.03 9.92 17 406726 768 110181788
Hypovolaemic shock 15.98 9.92 18 406725 14565 110167991
Cutaneous vasculitis 15.92 9.92 14 406729 12715 110169841
Retching 15.91 9.92 140 406603 22542 110160014
Pseudomonas infection 15.87 9.92 51 406692 27802 110154754
Hyperuricaemia 15.86 9.92 18 406725 14513 110168043
Bradypnoea 15.80 9.92 6 406737 8643 110173913
Toothache 15.76 9.92 144 406599 23431 110159125
Mania 15.75 9.92 33 406710 20763 110161793
Intercepted product preparation error 15.71 9.92 3 406740 6817 110175739
Taste disorder 15.71 9.92 159 406584 65228 110117328
Liver function test abnormal 15.61 9.92 170 406573 68780 110113776
Multiple drug therapy 15.61 9.92 5 406738 8009 110174547
Specific gravity urine increased 15.55 9.92 14 406729 516 110182040
Hepatitis fulminant 15.54 9.92 6 406737 8554 110174002
Sarcoidosis 15.53 9.92 14 406729 12565 110169991
Metastases to liver 15.53 9.92 72 406671 35314 110147242
Femoral neck fracture 15.50 9.92 14 406729 12553 110170003
Sinus headache 15.34 9.92 53 406690 5979 110176577
Head discomfort 15.31 9.92 121 406622 18879 110163677
Urinary retention 15.31 9.92 173 406570 69510 110113046
Haemodialysis 15.28 9.92 26 406717 17693 110164863
Disturbance in attention 15.21 9.92 150 406593 61845 110120711
Dermatitis allergic 15.20 9.92 36 406707 21688 110160868
Acute generalised exanthematous pustulosis 15.08 9.92 36 406707 21628 110160928
Urogenital prolapse 15.07 9.92 5 406738 20 110182536
Obstruction 15.03 9.92 51 406692 5701 110176855
Increased tendency to bruise 15.02 9.92 84 406659 11674 110170882
Unintentional medical device removal 15.00 9.92 7 406736 8916 110173640
Diabetes mellitus 14.99 9.92 266 406477 99115 110083441
Inflammation 14.98 9.92 570 406173 192668 109989888
Drug effective for unapproved indication 14.98 9.92 18 406725 14149 110168407
Psychomotor retardation 14.93 9.92 5 406738 7787 110174769
Abortion spontaneous 14.90 9.92 70 406673 34212 110148344
Peripheral sensory neuropathy 14.83 9.92 24 406719 16656 110165900
Culture urine positive 14.78 9.92 45 406698 4751 110177805
Skin ulcer 14.78 9.92 156 406587 63489 110119067
Vein collapse 14.77 9.92 21 406722 1286 110181270
Respiratory distress 14.74 9.92 172 406571 68702 110113854
Escherichia infection 14.73 9.92 42 406701 23774 110158782
Reversible airways obstruction 14.68 9.92 30 406713 2469 110180087
Migraine 14.65 9.92 772 405971 170880 110011676
Foot fracture 14.60 9.92 151 406592 25395 110157161
Renal tubular necrosis 14.59 9.92 60 406683 30415 110152141
Loss of consciousness 14.57 9.92 582 406161 195724 109986832
Limb discomfort 14.53 9.92 221 406522 40633 110141923
Mydriasis 14.50 9.92 38 406705 22119 110160437
Cardiac failure acute 14.50 9.92 43 406700 24035 110158521
White coat hypertension 14.48 9.92 21 406722 1310 110181246
Maternal exposure before pregnancy 14.46 9.92 59 406684 7206 110175350
Endophthalmitis 14.43 9.92 6 406737 8181 110174375
Sputum culture positive 14.42 9.92 39 406704 3850 110178706
Sudden death 14.37 9.92 44 406699 24351 110158205
Pulmonary haemorrhage 14.33 9.92 24 406719 16432 110166124
Coagulopathy 14.22 9.92 90 406653 40821 110141735
Venoocclusive disease 14.20 9.92 3 406740 6347 110176209
Blood phosphorus increased 14.07 9.92 24 406719 16316 110166240
Diffuse large B-cell lymphoma recurrent 14.04 9.92 3 406740 6296 110176260
Blood pressure abnormal 14.00 9.92 135 406608 22289 110160267
Duodenal ulcer haemorrhage 13.99 9.92 6 406737 8031 110174525
Drug tolerance decreased 13.97 9.92 53 406690 27487 110155069
Lupus vulgaris 13.93 9.92 188 406555 33695 110148861
End stage renal disease 13.92 9.92 37 406706 21436 110161120
Type 2 diabetes mellitus 13.91 9.92 522 406221 176710 110005846
Polymenorrhoea 13.85 9.92 19 406724 1125 110181431
Localised infection 13.85 9.92 229 406514 42819 110139737
Blood lactic acid increased 13.84 9.92 23 406720 15798 110166758
Road traffic accident 13.83 9.92 504 406239 106894 110075662
Ileus 13.80 9.92 62 406681 30667 110151889
Respiratory symptom 13.76 9.92 21 406722 14924 110167632
Exposure to SARS-CoV-2 13.69 9.92 32 406711 2887 110179669
Back injury 13.68 9.92 110 406633 47289 110135267
Abdominal distension 13.68 9.92 516 406227 174587 110007969
Dermatitis atopic 13.68 9.92 149 406594 25392 110157164
Areflexia 13.58 9.92 4 406739 6765 110175791
Basal cell carcinoma 13.56 9.92 104 406639 45166 110137390
Dysstasia 13.55 9.92 183 406560 32803 110149753
Lichen sclerosus 13.55 9.92 19 406724 1149 110181407
International normalised ratio increased 13.49 9.92 231 406512 86541 110096015
Rebound effect 13.45 9.92 21 406722 14785 110167771
Encephalitis 13.36 9.92 31 406712 18808 110163748
Pyrexia 13.36 9.92 3604 403139 894661 109287895
Creatinine urine decreased 13.35 9.92 11 406732 359 110182197
Multiple sclerosis 13.34 9.92 149 406594 25549 110157007
Genital haemorrhage 13.30 9.92 5 406738 7247 110175309
Injection site erythema 13.29 9.92 255 406488 93921 110088635
Migraine without aura 13.26 9.92 14 406729 629 110181927
Lip pruritus 13.15 9.92 20 406723 1302 110181254
Foreign body 13.14 9.92 32 406711 2963 110179593
Staphylococcal bacteraemia 13.05 9.92 26 406717 16662 110165894
Aggression 13.01 9.92 147 406596 59063 110123493
Osteoporosis 12.99 9.92 416 406327 86736 110095820
Hypertensive crisis 12.95 9.92 46 406697 24326 110158230
Hypoproteinaemia 12.91 9.92 3 406740 5942 110176614
Human papilloma virus test positive 12.91 9.92 14 406729 649 110181907
Salivary hypersecretion 12.90 9.92 28 406715 17393 110165163
Hepatitis toxic 12.83 9.92 3 406740 5918 110176638
Monocytosis 12.82 9.92 23 406720 1717 110180839
Mean cell haemoglobin concentration decreased 12.81 9.92 48 406695 5634 110176922
Electrocardiogram ST segment elevation 12.81 9.92 9 406734 9151 110173405
Neuralgia 12.81 9.92 250 406493 48228 110134328
Bone pain 12.80 9.92 322 406421 64811 110117745
Cytopenia 12.79 9.92 62 406681 30054 110152502
Bronchial wall thickening 12.75 9.92 33 406710 3174 110179382
Ventricular arrhythmia 12.73 9.92 11 406732 10076 110172480
Swelling face 12.72 9.92 251 406492 92070 110090486
Intracranial pressure increased 12.68 9.92 12 406731 10523 110172033
Diplopia 12.67 9.92 96 406647 41798 110140758
Nonspecific reaction 12.60 9.92 32 406711 3042 110179514
Injection site extravasation 12.56 9.92 72 406671 10097 110172459
Pericarditis 12.54 9.92 952 405791 218162 109964394
Enterococcal infection 12.53 9.92 36 406707 20330 110162226
Urinary casts present 12.52 9.92 7 406736 118 110182438
Facet joint syndrome 12.52 9.92 266 406477 96562 110085994
General symptom 12.52 9.92 65 406678 8781 110173775
Testicular mass 12.52 9.92 7 406736 118 110182438
Toxic encephalopathy 12.51 9.92 23 406720 15191 110167365
Abnormal behaviour 12.50 9.92 88 406655 38951 110143605
Hypoaesthesia oral 12.48 9.92 106 406637 16896 110165660
Gastric disorder 12.47 9.92 182 406561 33175 110149381
Musculoskeletal discomfort 12.46 9.92 137 406606 23401 110159155
Type I hypersensitivity 12.43 9.92 4 406739 6389 110176167
Hand fracture 12.42 9.92 61 406682 8061 110174495
Scratch 12.36 9.92 86 406657 12893 110169663
Oral pain 12.35 9.92 200 406543 37244 110145312
Psychiatric decompensation 12.34 9.92 3 406740 5762 110176794
Accidental exposure to product 12.26 9.92 121 406622 49887 110132669
Diabetes mellitus inadequate control 12.24 9.92 62 406681 29713 110152843
Restlessness 12.23 9.92 140 406603 56119 110126437
Deep vein thrombosis postoperative 12.21 9.92 295 406448 58996 110123560
Tenosynovitis 12.20 9.92 26 406717 16257 110166299
Organising pneumonia 12.19 9.92 21 406722 14222 110168334
Papilloedema 12.17 9.92 6 406737 7403 110175153
Metastases to lymph nodes 12.12 9.92 23 406720 15009 110167547
Hospice care 12.09 9.92 83 406660 12390 110170166
Snapping hip syndrome 12.06 9.92 4 406739 16 110182540
Myopathy 12.04 9.92 49 406694 24911 110157645
Urethral meatus stenosis 12.00 9.92 5 406738 42 110182514
Substance abuse 11.98 9.92 17 406726 12446 110170110
Metastases to lung 11.95 9.92 44 406699 23019 110159537
Transplant failure 11.93 9.92 3 406740 5632 110176924
Hypotonia 11.91 9.92 25 406718 15720 110166836
Injection site pain 11.84 9.92 534 406209 177388 110005168
Myasthenia gravis 11.84 9.92 40 406703 21471 110161085
Urine ketone body present 11.78 9.92 36 406707 3810 110178746
Stupor 11.72 9.92 8 406735 8257 110174299
Band sensation 11.71 9.92 17 406726 1061 110181495
Overweight 11.70 9.92 51 406692 6413 110176143
Tongue oedema 11.70 9.92 8 406735 8248 110174308
Mycobacterial disease carrier 11.68 9.92 4 406739 18 110182538
Heart rate irregular 11.65 9.92 184 406559 34090 110148466
Middle insomnia 11.63 9.92 121 406622 20381 110162175
Autoimmune haemolytic anaemia 11.63 9.92 13 406730 10554 110172002
Cyanosis 11.63 9.92 63 406680 29678 110152878
Catheter site abscess 11.60 9.92 9 406734 269 110182287
Upper gastrointestinal haemorrhage 11.55 9.92 123 406620 49973 110132583
Cardiomyopathy 11.52 9.92 74 406669 33451 110149105
Pleural effusion 11.50 9.92 535 406208 177174 110005382
Metabolic disorder 11.49 9.92 13 406730 10497 110172059
Impaired work ability 11.45 9.92 54 406689 26365 110156191
Noninfective gingivitis 11.43 9.92 24 406719 2013 110180543
Neutrophil count decreased 11.41 9.92 348 406395 120593 110061963
Normochromic normocytic anaemia 11.41 9.92 19 406724 13038 110169518
Therapeutic response decreased 11.37 9.92 269 406474 96230 110086326
Nitrite urine present 11.33 9.92 18 406725 1217 110181339
Multiple sclerosis relapse 11.28 9.92 253 406490 49987 110132569
Red blood cell sedimentation rate abnormal 11.28 9.92 49 406694 24460 110158096
Subdural haematoma 11.28 9.92 83 406660 36371 110146185
Hangover 11.27 9.92 27 406716 2475 110180081
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.24 9.92 3 406740 5414 110177142
Cushingoid 11.23 9.92 16 406727 11696 110170860
Pancreatitis 11.22 9.92 260 406483 93273 110089283
Mass 11.21 9.92 116 406627 19514 110163042
Blood uric acid increased 11.20 9.92 41 406702 21488 110161068
Endodontic procedure 11.18 9.92 31 406712 3105 110179451
Vitello-intestinal duct remnant 11.17 9.92 7 406736 147 110182409
Hepatic necrosis 11.15 9.92 12 406731 9910 110172646
Pneumatosis intestinalis 11.13 9.92 9 406734 8520 110174036
Muscle strain 11.13 9.92 75 406668 11127 110171429
Mycotic allergy 11.10 9.92 4 406739 5950 110176606
Drug dose omission by device 11.02 9.92 23 406720 14493 110168063
Hypothalamo-pituitary disorder 11.02 9.92 29 406714 2817 110179739
Blood calcium increased 11.02 9.92 32 406711 18008 110164548
Red blood cell count decreased 10.99 9.92 319 406424 65604 110116952
Delirium 10.97 9.92 396 406347 134629 110047927
Dissociation 10.95 9.92 12 406731 9830 110172726
Macular oedema 10.91 9.92 6 406737 6960 110175596
Urosepsis 10.91 9.92 67 406676 30608 110151948
Rash pustular 10.90 9.92 19 406724 12810 110169746
Flail chest 10.85 9.92 6 406737 99 110182457
Adulterated product 10.82 9.92 17 406726 1138 110181418
Eyelash discolouration 10.79 9.92 6 406737 100 110182456
Haemolytic anaemia 10.78 9.92 40 406703 20880 110161676
Infusion site bruising 10.78 9.92 34 406709 3660 110178896
Activated partial thromboplastin time prolonged 10.74 9.92 44 406699 22324 110160232
Vitamin B12 decreased 10.71 9.92 43 406700 5214 110177342
Varicella zoster virus infection 10.70 9.92 5 406738 6363 110176193
Hip arthroplasty 10.70 9.92 275 406468 55538 110127018
Urine analysis abnormal 10.69 9.92 52 406691 6845 110175711
Tachypnoea 10.66 9.92 93 406650 39302 110143254
Polyarthritis 10.61 9.92 35 406708 18928 110163628
Red blood cell sedimentation rate 10.61 9.92 3 406740 5211 110177345
Pharyngeal disorder 10.57 9.92 28 406715 2731 110179825
Cranial nerve decompression 10.55 9.92 3 406740 6 110182550
Allergic transfusion reaction 10.52 9.92 8 406735 232 110182324
Confusional state 10.49 9.92 1917 404826 466763 109715793
Hepatic enzyme 10.45 9.92 3 406740 5160 110177396
Withdrawal syndrome 10.42 9.92 70 406673 31310 110151246
Respiratory alkalosis 10.40 9.92 4 406739 5717 110176839
Product use issue 10.40 9.92 1304 405439 310391 109872165
Intervertebral disc degeneration 10.38 9.92 107 406636 17978 110164578
Device related infection 10.38 9.92 94 406649 39425 110143131
Brain abscess 10.37 9.92 6 406737 6768 110175788
Hepatitis C 10.34 9.92 19 406724 12554 110170002
Diverticulitis 10.34 9.92 264 406479 53258 110129298
Breast cancer stage III 10.33 9.92 217 406526 78900 110103656
Cardiac tamponade 10.30 9.92 16 406727 11291 110171265
Extrapyramidal disorder 10.29 9.92 63 406680 28804 110153752
Device use error 10.20 9.92 11 406732 9078 110173478
Blood iron increased 10.20 9.92 24 406719 2174 110180382
Arthritis bacterial 10.16 9.92 15 406728 10805 110171751
Neck pain 10.15 9.92 552 406191 122578 110059978
Thymoma 10.14 9.92 10 406733 414 110182142
Disturbance in social behaviour 10.13 9.92 3 406740 5055 110177501
Retinal haemorrhage 10.12 9.92 12 406731 9489 110173067
Pseudomonal sepsis 10.10 9.92 11 406732 9035 110173521
Metamorphopsia 10.07 9.92 20 406723 1613 110180943
Migraine with aura 10.06 9.92 32 406711 3460 110179096
Delusion 10.03 9.92 49 406694 23706 110158850
Fibrosis 10.03 9.92 55 406688 7587 110174969
Neck injury 10.02 9.92 30 406713 3138 110179418
Total lung capacity decreased 9.94 9.92 7 406736 7107 110175449
Arteriosclerosis coronary artery 9.94 9.92 53 406690 25065 110157491

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05CA03 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Expectorants
FDA PE N0000008867 Decreased Respiratory Secretion Viscosity
FDA PE N0000009560 Increased Respiratory Secretions
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:51177 antitussive
FDA EPC N0000193956 Expectorant

Related Drugs by ATC class:

R05CA Expectorants 7 drugs
antimony pentasulfidecineolecreosotelevoverbenonepotassium iodidesulfogaiacoltyloxapol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Fever indication 386661006
Asthma off-label use 195967001 DOID:2841
Asthma-chronic obstructive pulmonary disease overlap syndrome off-label use 10692761000119107
COPD Associated with Chronic Bronchitis off-label use
Chronic Obstructive Pulmonary Disease with Bronchospasms off-label use
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Alcoholic liver damage contraindication 41309000
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by phenobarbital contraindication 64921004
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Cystic fibrosis contraindication 190905008 DOID:1485
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Smoking cessation assistance contraindication 384742004
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Fever greater than 100.4 Fahrenheit contraindication 426000000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

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Gecolate, Glycodex Injection Summit Hill Laboratories 1
Guailaxin Zoetis Inc. 1
Guaifenesin Injection Elanco US Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 10105324 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9549907 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4
200MG/5ML;2.5MG/5ML OBREDON SOVEREIGN PHARMS N205474 Nov. 14, 2014 DISCN SOLUTION ORAL 9808431 Nov. 13, 2035 A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018147 VUID
N0000146484 NUI
D00337 KEGG_DRUG
4018147 VANDF
C0018305 UMLSCUI
CHEBI:5551 CHEBI
CHEMBL980 ChEMBL_ID
DB00874 DRUGBANK_ID
D006140 MESH_DESCRIPTOR_UI
3516 PUBCHEM_CID
7617 IUPHAR_LIGAND_ID
968 INN_ID
495W7451VQ UNII
5032 RXNORM
2461 MMSL
4805 MMSL
d00797 MMSL
000724 NDDF
386184000 SNOMEDCT_US
87174009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 3 0031-0100 LIQUID 400 mg ORAL OTC Monograph Drug 16 sections
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2097 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
Childrens Robitussin Elderberry Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2098 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 100 mg ORAL Export only 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8702 LIQUID 200 mg ORAL OTC Monograph Drug 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8715 LIQUID 100 mg ORAL OTC Monograph Drug 15 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 50 mg ORAL OTC Monograph Drug 17 sections
Robitussin Maximum Strength Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8719 CAPSULE, LIQUID FILLED 200 mg ORAL OTC Monograph Drug 15 sections
Robitussin Mucus Plus Chest Congestion HUMAN OTC DRUG LABEL 1 0031-8724 LIQUID 200 mg ORAL OTC MONOGRAPH FINAL 14 sections
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8739 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8739 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 100 mg ORAL OTC Monograph Drug 17 sections
ROBITUSSIN CHEST CONGESTION HUMAN OTC DRUG LABEL 1 0031-8748 LIQUID 100 mg ORAL EXPORT ONLY 1 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 400 mg ORAL OTC Monograph Drug 17 sections
Robitussin Honey Maximum Strength Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8756 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8757 SOLUTION 200 mg ORAL OTC Monograph Drug 15 sections
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8759 SOLUTION 200 mg ORAL OTC Monograph Drug 15 sections
Childrens Robitussin Honey Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8760 SOLUTION 100 mg ORAL OTC Monograph Drug 15 sections
Robitussin Maximum Strength 12 Hour Cough and Mucus Relief HUMAN OTC DRUG LABEL 2 0031-8765 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 16 sections
Theraflu Severe Cold Relief Chest Congestion Daytime HUMAN OTC DRUG LABEL 3 0067-0104 SYRUP 400 mg ORAL OTC Monograph Drug 15 sections
Theraflu ExpressMax Severe Cold and Flu Syrup HUMAN OTC DRUG LABEL 4 0067-8132 SYRUP 400 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Severe Cold and Flu Caplets HUMAN OTC DRUG LABEL 4 0067-8145 TABLET, COATED 200 mg ORAL OTC Monograph Drug 16 sections
Good Sense Severe Daytime Cold and Flu HUMAN OTC DRUG LABEL 4 0113-0603 SOLUTION 200 mg ORAL OTC Monograph Drug 16 sections
good sense mucus dm HUMAN OTC DRUG LABEL 2 0113-0812 TABLET, EXTENDED RELEASE 1200 mg ORAL ANDA 15 sections
Good Sense Tussin DM Max HUMAN OTC DRUG LABEL 2 0113-0927 SOLUTION 400 mg ORAL OTC Monograph Drug 14 sections
good sense tussin dm HUMAN OTC DRUG LABEL 2 0113-1725 SOLUTION 200 mg ORAL OTC Monograph Drug 14 sections
GOOD SENSE TUSSIN HUMAN OTC DRUG LABEL 3 0113-2009 SOLUTION 400 mg ORAL OTC Monograph Drug 15 sections
good sense mucus er HUMAN OTC DRUG LABEL 1 0113-2023 TABLET, MULTILAYER, EXTENDED RELEASE 600 mg ORAL ANDA 14 sections
Good Sense Mucus DM HUMAN OTC DRUG LABEL 2 0113-2219 TABLET, EXTENDED RELEASE 600 mg ORAL ANDA 15 sections
good sense day time cold and flu HUMAN OTC DRUG LABEL 4 0113-2299 SOLUTION 200 mg ORAL OTC Monograph Drug 16 sections