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glutathione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1312 | 70-18-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 57 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK9,GRK2,MAP2K6,MAPK7,TEK,TGFBR1 | 9 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 146.90 | 24.04 | 52 | 2245 | 46236 | 90579914 |
| Platelet count decreased | 56.67 | 24.04 | 38 | 2259 | 136931 | 90489219 |
| Drug-induced liver injury | 54.88 | 24.04 | 32 | 2265 | 90286 | 90535864 |
| White blood cell count decreased | 54.33 | 24.04 | 40 | 2257 | 167069 | 90459081 |
| Neutrophil count decreased | 45.18 | 24.04 | 26 | 2271 | 71506 | 90554644 |
| Alanine aminotransferase increased | 44.58 | 24.04 | 31 | 2266 | 118307 | 90507843 |
| Aspartate aminotransferase increased | 43.60 | 24.04 | 29 | 2268 | 102908 | 90523242 |
| Lymphocyte count decreased | 43.25 | 24.04 | 20 | 2277 | 35030 | 90591120 |
| Eosinophilic pneumonia chronic | 42.62 | 24.04 | 7 | 2290 | 224 | 90625926 |
| Anaemia | 38.59 | 24.04 | 46 | 2251 | 352756 | 90273394 |
| Chronic disease | 36.04 | 24.04 | 6 | 2291 | 209 | 90625941 |
| Hypoalbuminaemia | 32.60 | 24.04 | 13 | 2284 | 15884 | 90610266 |
| Hypoproteinaemia | 28.97 | 24.04 | 8 | 2289 | 3134 | 90623016 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 112.66 | 29.88 | 50 | 1637 | 51517 | 42568131 |
| Platelet count decreased | 71.09 | 29.88 | 52 | 1635 | 138529 | 42481119 |
| Lymphocyte count decreased | 60.70 | 29.88 | 27 | 1660 | 27782 | 42591866 |
| Neutrophil count increased | 59.06 | 29.88 | 24 | 1663 | 19780 | 42599868 |
| Incision site pain | 48.97 | 29.88 | 12 | 1675 | 1891 | 42617757 |
| Drug-induced liver injury | 46.77 | 29.88 | 25 | 1662 | 38248 | 42581400 |
| Myelosuppression | 42.72 | 29.88 | 24 | 1663 | 40437 | 42579211 |
| Alanine aminotransferase increased | 40.35 | 29.88 | 31 | 1656 | 88375 | 42531273 |
| White blood cell count decreased | 34.32 | 29.88 | 31 | 1656 | 110365 | 42509283 |
| Neutrophil count decreased | 30.59 | 29.88 | 23 | 1664 | 63392 | 42556256 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 240.89 | 25.05 | 98 | 3898 | 89197 | 110496106 |
| Platelet count decreased | 133.40 | 25.05 | 90 | 3906 | 230353 | 110354950 |
| Lymphocyte count decreased | 114.83 | 25.05 | 51 | 3945 | 57192 | 110528111 |
| White blood cell count decreased | 92.45 | 25.05 | 72 | 3924 | 229318 | 110355985 |
| Drug-induced liver injury | 91.91 | 25.05 | 56 | 3940 | 120011 | 110465292 |
| Neutrophil count decreased | 83.93 | 25.05 | 53 | 3943 | 120888 | 110464415 |
| Alanine aminotransferase increased | 81.29 | 25.05 | 61 | 3935 | 183712 | 110401591 |
| Incision site pain | 68.34 | 25.05 | 17 | 3979 | 3118 | 110582185 |
| Myelosuppression | 64.56 | 25.05 | 41 | 3955 | 94299 | 110491004 |
| Aspartate aminotransferase increased | 63.91 | 25.05 | 50 | 3946 | 159886 | 110425417 |
| Neutrophil count increased | 63.48 | 25.05 | 29 | 3967 | 34623 | 110550680 |
| Hypoalbuminaemia | 58.64 | 25.05 | 26 | 3970 | 28948 | 110556355 |
| Anaemia | 54.91 | 25.05 | 82 | 3914 | 547004 | 110038299 |
| Red blood cells urine positive | 42.32 | 25.05 | 13 | 3983 | 5172 | 110580131 |
| Chronic disease | 40.14 | 25.05 | 7 | 3989 | 224 | 110585079 |
| Hypocalcaemia | 38.80 | 25.05 | 26 | 3970 | 65340 | 110519963 |
| Blood albumin decreased | 38 | 25.05 | 19 | 3977 | 27633 | 110557670 |
| Hypokalaemia | 37.05 | 25.05 | 39 | 3957 | 182409 | 110402894 |
| Hypoproteinaemia | 36.51 | 25.05 | 12 | 3984 | 5933 | 110579370 |
| Eosinophilic pneumonia chronic | 33.86 | 25.05 | 7 | 3989 | 560 | 110584743 |
| White blood cell count increased | 29.71 | 25.05 | 26 | 3970 | 96816 | 110488487 |
| Hyperuricaemia | 29.26 | 25.05 | 13 | 3983 | 14518 | 110570785 |
| Gamma-glutamyltransferase increased | 28.49 | 25.05 | 21 | 3975 | 61288 | 110524015 |
| Hypophosphataemia | 26.68 | 25.05 | 16 | 3980 | 33166 | 110552137 |
| Blood bilirubin increased | 26.58 | 25.05 | 22 | 3974 | 75950 | 110509353 |
| Liver injury | 25.06 | 25.05 | 29 | 3967 | 150384 | 110434919 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V03AB32 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes |
| CHEBI has role | CHEBI:22586 | antioxidant |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
| CHEBI has role | CHEBI:85046 | skin lightening agent |
| CHEBI has role | CHEBI:176497 | geroprotector |
Related Drugs by ATC class:
V03AB Antidotes 28 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.97 | acidic |
| pKa2 | 3.3 | acidic |
| pKa3 | 9.09 | acidic |
| pKa4 | 11.82 | acidic |
| pKa5 | 13.85 | acidic |
| pKa6 | 9.79 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glutathione S-transferase kappa 1 | Enzyme | IC50 | 7.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020562 | VUID |
| N0000148266 | NUI |
| D00014 | KEGG_DRUG |
| 4020562 | VANDF |
| C0202053 | UMLSCUI |
| CHEBI:16856 | CHEBI |
| 0P0 | PDB_CHEM_ID |
| CHEMBL1543 | ChEMBL_ID |
| DB00143 | DRUGBANK_ID |
| D005978 | MESH_DESCRIPTOR_UI |
| 124886 | PUBCHEM_CID |
| 6737 | IUPHAR_LIGAND_ID |
| GAN16C9B8O | UNII |
| 4890 | RXNORM |
| 37752 | MMSL |
| 382529 | MMSL |
| NOCODE | MMSL |
| d09739 | MMSL |
| 003447 | NDDF |
| 423272009 | SNOMEDCT_US |
| 55477000 | SNOMEDCT_US |
| GAN16C9B8O | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Bio-7 Serum | HUMAN OTC DRUG LABEL | 2 | 71583-1002 | LIQUID | 3 g | TOPICAL | unapproved drug other | 7 sections |
| Bio-7 | HUMAN OTC DRUG LABEL | 2 | 71583-1003 | CREAM | 3.26 g | TOPICAL | unapproved drug other | 7 sections |
| GZE AHA BodyLotion | HUMAN OTC DRUG LABEL | 3 | 74458-020 | CREAM | 0.10 g | TOPICAL | OTC Monograph Drug | 10 sections |
| GZE Glutathione BrighteningSoap | HUMAN OTC DRUG LABEL | 1 | 74458-331 | SOAP | 2 g | TOPICAL | OTC Monograph Drug | 11 sections |
| MELAO Kojic Acid BodyLotion | HUMAN OTC DRUG LABEL | 2 | 74458-357 | LOTION | 1 g | TOPICAL | OTC Monograph Drug | 10 sections |
| HARUTO HANGOVER DEFENCEPATCH | HUMAN OTC DRUG LABEL | 1 | 80094-0001 | PATCH | 1.42 mg | TOPICAL | unapproved drug other | 7 sections |
| ST.LAWRENCE ANTI-AGING AND WHITENING MASK | HUMAN OTC DRUG LABEL | 5 | 81309-010 | LIQUID | 4 g | TOPICAL | OTC Monograph Drug | |
| Deyanling(Cranberry Flavored Collagen Peptide) | HUMAN OTC DRUG LABEL | 3 | 82570-004 | POWDER | 5 g | TOPICAL | unapproved drug other | 8 sections |
| Dark knucklee SERUM | HUMAN OTC DRUG LABEL | 3 | 84423-004 | OIL | 0.25 mg | CUTANEOUS | OTC Monograph Drug | 9 sections |
| 5D Gluta Organic Exfoliating Cream Premium Glutathione Powder | HUMAN OTC DRUG LABEL | 3 | 84423-005 | EMULSION | 0.00 g | CUTANEOUS | OTC Monograph Drug | 9 sections |
| 7 Days Whitening Face Cream | HUMAN OTC DRUG LABEL | 3 | 84423-006 | CREAM | 0.25 mg | CUTANEOUS | OTC Monograph Drug | 9 sections |
| STRONG WHITENING BATH | HUMAN OTC DRUG LABEL | 2 | 84423-008 | EMULSION | 0.50 mg | CUTANEOUS | OTC Monograph Drug | 7 sections |
| GLUTA PRIMME body oil | HUMAN OTC DRUG LABEL | 2 | 84423-009 | OIL | 0.40 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Glutathione And Kojic Atid Exfoliating BlackSoap | HUMAN OTC DRUG LABEL | 3 | 84423-011 | SOAP | 0.25 mg | CUTANEOUS | OTC Monograph Drug | 9 sections |
| 5 DAYS WHITENING BOOSTER | HUMAN OTC DRUG LABEL | 3 | 84423-017 | LIQUID | 0.80 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Half Cast Whitening Serum STRONG | HUMAN OTC DRUG LABEL | 3 | 84423-018 | LIQUID | 1.20 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Diamond Radiance Body Serum | HUMAN OTC DRUG LABEL | 2 | 84423-019 | LIQUID | 1.20 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| STRONG WHITENING BODY SERUM | HUMAN OTC DRUG LABEL | 3 | 84423-020 | LIQUID | 0.36 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| 7 DAYS ADUANCED WHITENING MAXIMUM BOOST SERUM | HUMAN OTC DRUG LABEL | 3 | 84423-021 | LIQUID | 0.96 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| EXFOLIATING WHITENING BOYD SCRUB | HUMAN OTC DRUG LABEL | 2 | 84423-023 | EMULSION | 0.90 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Papaya Whitening BodyLotion | HUMAN OTC DRUG LABEL | 2 | 84423-025 | EMULSION | 1.95 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| 7 Days Extra Whitening BodyLotion | HUMAN OTC DRUG LABEL | 2 | 84423-027 | EMULSION | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Shine BodyLotion | HUMAN OTC DRUG LABEL | 2 | 84423-028 | EMULSION | 5 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| MIRACLE SUPER WHITE BODYLOTION | HUMAN OTC DRUG LABEL | 5 | 84423-031 | EMULSION | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| 7Days Advanced Whitening BodyLotion | HUMAN OTC DRUG LABEL | 3 | 84423-032 | EMULSION | 4 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| MAGIC POTION BLEACHING SHOWER GELIN | HUMAN OTC DRUG LABEL | 2 | 84423-033 | EMULSION | 0.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Goqi Berry Body Lotio | HUMAN OTC DRUG LABEL | 2 | 84423-039 | CREAM, AUGMENTED | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Carrot BodyLotion | HUMAN OTC DRUG LABEL | 3 | 84423-040 | EMULSION | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Papaya Oil Whitening BodyLotion | HUMAN OTC DRUG LABEL | 3 | 84423-041 | EMULSION | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |
| Brightening and Anti Aging BodyLotion | HUMAN OTC DRUG LABEL | 3 | 84423-042 | EMULSION | 2.50 mg | CUTANEOUS | OTC Monograph Drug | 8 sections |