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fomepizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1233 | 7554-65-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.35 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.73 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.42 hours | Lombardo F, Berellini G, Obach RS |
| BA (Bioavailability) | 100 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,MAP3K10,MAP3K21,MAP4K1,MAP4K3,MAPK1,MAPK12,MAPK7,MAPK9,MARK4,NTRK2,PDK1,PDK2,PRKCD,PRKDC,ROCK1,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 50 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AURKB,AXL,BRAF,CAMK2D,DYRK1B,ERBB2,GRK2,GRK3,IRAK1,MAP3K10,MAP3K11,MAP3K21,MAPK1,SIK2,SIK3 | 17 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 4, 1997 | FDA | PALADIN LABS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V03AB34 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes |
| FDA EPC | N0000175429 | Antidote |
| MeSH PA | D000931 | Antidotes |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:50247 | antidote |
| CHEBI has role | CHEBI:50267 | protective agent |
| CHEBI has role | CHEBI:50269 | EC 1.1.1.1 (alcohol dehydrogenase) inhibitor |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
Related Drugs by ATC class:
V03AB Antidotes 28 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Accidental poisoning by methyl alcohol | indication | 216640006 | |
| Ethylene Glycol Toxicity | indication | ||
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Antidote for ethylene glycol (antifreeze) poisoning | Indication |
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.62 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alcohol dehydrogenase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Alcohol dehydrogenase | Enzyme | Kd | 7.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 83LCM6L2BY | UNII |
| 4021081 | VUID |
| N0000148539 | NUI |
| D00707 | KEGG_DRUG |
| 4021081 | VANDF |
| C0048504 | UMLSCUI |
| CHEBI:5141 | CHEBI |
| CHEMBL1308 | ChEMBL_ID |
| 3406 | PUBCHEM_CID |
| DB01213 | DRUGBANK_ID |
| D000077604 | MESH_DESCRIPTOR_UI |
| 6633 | INN_ID |
| 11705 | IUPHAR_LIGAND_ID |
| 15226 | RXNORM |
| 11512 | MMSL |
| 130106 | MMSL |
| 4762 | MMSL |
| d04274 | MMSL |
| 007238 | NDDF |
| 109100006 | SNOMEDCT_US |
| 386970006 | SNOMEDCT_US |
| 4PZ | PDB_CHEM_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-0710 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
| fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0517-0710 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 21 sections |
| Fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-829 | INJECTION | 1.50 g | INTRAVENOUS | ANDA | 22 sections |
| Antizol | Human Prescription Drug Label | 1 | 46129-200 | INJECTION | 1 g | INTRAVENOUS | NDA | 19 sections |
| Fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-211 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 22 sections |
| Fomepizole | Human Prescription Drug Label | 1 | 68083-510 | INJECTION | 1 g | INTRAVENOUS | ANDA | 17 sections |
| Fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68475-510 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 11 sections |
| Fomepizole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-1478 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 11 sections |