cetrimide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4360 8044-71-1

Description:

MoleculeDescription

Synonyms:

  • cetrimide
  • cetavlon
  • quammonium
  • Molecular weight:
  • Formula: C4H11BrN(CH3)11,13,15
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle injury 239.93 69.39 242 19751 176412 90432042
Sleep disorder due to general medical condition, insomnia type 223.52 69.39 202 19791 128492 90479962
Irritable bowel syndrome 216.20 69.39 247 19746 207201 90401253
Folliculitis 176.18 69.39 221 19772 204132 90404322
Duodenal ulcer perforation 171.49 69.39 227 19766 221061 90387393
Lower respiratory tract infection 166.98 69.39 239 19754 250420 90358034
Anti-cyclic citrullinated peptide antibody positive 145.20 69.39 217 19776 236216 90372238
Helicobacter infection 144.76 69.39 212 19781 226638 90381816
Deep vein thrombosis postoperative 138.52 69.39 119 19874 70690 90537764
Impaired healing 133.97 69.39 208 19785 233991 90374463
Blister 128.81 69.39 214 19779 254784 90353670
Stomatitis 127.50 69.39 222 19771 274476 90333978
Lower limb fracture 127.36 69.39 123 19870 84890 90523564
Autoimmune disorder 120.58 69.39 114 19879 76630 90531824
Pericarditis 119.77 69.39 214 19779 269937 90338517
Gastrointestinal disorder 118.52 69.39 207 19786 256480 90351974
Ill-defined disorder 118.20 69.39 173 19820 184718 90423736
Sinusitis 115.67 69.39 242 19751 342846 90265608
Hand deformity 112.94 69.39 220 19773 296142 90312312
Contusion 111.34 69.39 199 19794 251017 90357437
Discomfort 111.10 69.39 209 19784 274126 90334328
C-reactive protein 110.77 69.39 75 19918 31292 90577162
Sciatica 107.59 69.39 122 19871 101260 90507194
Prescribed overdose 97.73 69.39 114 19879 97511 90510943
Injury 93.44 69.39 161 19832 197188 90411266
Infection 91.56 69.39 228 19765 361866 90246588
Nausea 89.31 69.39 69 19924 1110247 89498207
Glossodynia 88.16 69.39 209 19784 321570 90286884
Liver disorder 87.07 69.39 120 19873 121149 90487305
Nasopharyngitis 85.30 69.39 239 19754 406865 90201589
Pemphigus 84.92 69.39 208 19785 326656 90281798
Road traffic accident 84.12 69.39 111 19882 107515 90500939
Peripheral venous disease 79.02 69.39 95 19898 83826 90524628
Synovitis 78.50 69.39 203 19790 329549 90278905
Sleep disorder 77.78 69.39 149 19844 197881 90410573
Facet joint syndrome 77.70 69.39 102 19891 98287 90510167
Systemic lupus erythematosus 75.32 69.39 212 19781 361684 90246770
Confusional state 72.46 69.39 218 19775 385987 90222467
Contraindicated product administered 72.03 69.39 193 19800 319946 90288508
Hepatic enzyme increased 71.84 69.39 208 19785 360528 90247926
Joint range of motion decreased 71.28 69.39 116 19877 135527 90472927

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle injury 262.59 103.17 201 17467 140606 110431025
Irritable bowel syndrome 243.60 103.17 205 17463 164010 110407621
Sleep disorder due to general medical condition, insomnia type 212.83 103.17 158 17510 105485 110466146
Duodenal ulcer perforation 194.62 103.17 187 17481 177513 110394118
Deep vein thrombosis postoperative 189.44 103.17 118 17550 59173 110512458
Folliculitis 184.66 103.17 177 17491 167476 110404155
Lower limb fracture 177.59 103.17 124 17544 75224 110496407
Anti-cyclic citrullinated peptide antibody positive 170.60 103.17 176 17492 181808 110389823
Autoimmune disorder 164.28 103.17 112 17556 65371 110506260
Lower respiratory tract infection 164.07 103.17 198 17470 242908 110328723
Helicobacter infection 159.93 103.17 170 17498 181707 110389924
Sciatica 152.87 103.17 123 17545 92276 110479355
Hand deformity 149.10 103.17 179 17489 218327 110353304
Impaired healing 137.23 103.17 163 17505 196554 110375077
C-reactive protein 135.44 103.17 75 17593 30256 110541375
Pericarditis 134.17 103.17 170 17498 218944 110352687
Sinusitis 133.12 103.17 198 17470 296490 110275141
Blister 132.30 103.17 172 17496 227204 110344427
Discomfort 132.13 103.17 167 17501 214540 110357091
Glossodynia 129.26 103.17 168 17500 221836 110349795
Prescribed overdose 126.96 103.17 108 17560 87473 110484158
Pemphigus 125.90 103.17 163 17505 214407 110357224
Stomatitis 116.41 103.17 177 17491 270065 110301566
Road traffic accident 111.78 103.17 110 17558 107288 110464343
Joint range of motion decreased 110.79 103.17 116 17552 121716 110449915
Gastrointestinal disorder 110.66 103.17 163 17505 241789 110329842
Systemic lupus erythematosus 110.13 103.17 167 17501 254171 110317460
Ill-defined disorder 106.10 103.17 128 17540 156725 110414906
Facet joint syndrome 106.07 103.17 102 17566 96726 110474905
Contusion 104.97 103.17 156 17512 233205 110338426
Peripheral venous disease 104.42 103.17 95 17573 84022 110487609

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ04 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D11AC01 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Medicated shampoos
CHEBI has role CHEBI:73336 vulnerary
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Related Drugs by ATC class:

D08AJ Quaternary ammonium compounds 9 drugs
benzalkoniumbenzethoniumbenzoxonium chloridecetrimoniumcetylpyridiniumdecamethoxinedidecyldimethylammonium chloridedodeclonium bromideoctenidine
D11AC Medicated shampoos 2 drugs
povidone-iodinexenysalate

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dynamin-1 Structural IC50 5.24 CHEMBL

External reference:

IDSource
D02164 KEGG_DRUG
C0950191 UMLSCUI
CHEBI:3565 CHEBI
CHEMBL5219790 ChEMBL_ID
5157 INN_ID
24QSH2NL8N UNII
288088 RXNORM
003518 NDDF
333179001 SNOMEDCT_US
395895003 SNOMEDCT_US
D000077286 MESH_DESCRIPTOR_UI
5974 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Derma Wound-Eaz HUMAN OTC DRUG LABEL 1 82160-696 CREAM 5 mg TOPICAL unapproved drug other 15 sections