ammonium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4350 12125-02-9

Description:

MoleculeDescription

Synonyms:

  • ammonium chloride
An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.
  • Molecular weight: 53.49
  • Formula: ClH4N
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
8.50 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 13, 1978 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myasthenia gravis 189.08 126.40 70 4647 16067 42600551
Hyperphosphataemia 184.54 126.40 65 4652 12939 42603679
Analgesic therapy 171.40 126.40 52 4665 6472 42610146
Drug therapy 163.97 126.40 50 4667 6330 42610288
Sleep disorder therapy 160.15 126.40 50 4667 6844 42609774
Appendicolith 156.24 126.40 58 4659 13398 42603220
Neuralgia 154.47 126.40 69 4648 25578 42591040
Hypophosphataemia 154.43 126.40 65 4652 20880 42595738
Blood phosphorus increased 141.79 126.40 53 4664 12472 42604146
Stress 140.66 126.40 77 4640 44135 42572483
Appendicitis 138.81 126.40 60 4657 20553 42596065
Incorrect route of product administration 135.60 126.40 62 4655 24243 42592375
Bacterial infection 133.54 126.40 64 4653 27815 42588803
Activated partial thromboplastin time prolonged 129.50 126.40 53 4664 15850 42600768

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myasthenia gravis 233.99 83.78 71 5008 21440 110562780
Hyperphosphataemia 230.47 83.78 66 5013 16315 110567905
Analgesic therapy 216.07 83.78 53 5026 7231 110576989
Appendicolith 207.56 83.78 59 5020 14196 110570024
Drug therapy 205.91 83.78 51 5028 7240 110576980
Sleep disorder therapy 204.67 83.78 51 5028 7420 110576800
Hypophosphataemia 188.44 83.78 67 5012 33115 110551105
Blood phosphorus increased 177.94 83.78 54 5025 16286 110567934
Appendicitis 175.08 83.78 61 5018 28403 110555817
Neuralgia 174.05 83.78 70 5009 48408 110535812
Bacterial infection 160.17 83.78 65 5014 45971 110538249
Activated partial thromboplastin time prolonged 157.29 83.78 53 5026 22315 110561905
Ventricular fibrillation 149.46 83.78 60 5019 41253 110542967
Anticoagulant therapy 148.84 83.78 37 5042 5324 110578896
Congenital hiatus hernia 148.03 83.78 38 5041 6221 110577999
Antacid therapy 148.01 83.78 37 5042 5447 110578773
Stress 144.22 83.78 78 5001 105270 110478950
Blood uric acid increased 135.69 83.78 47 5032 21482 110562738
Diabetes mellitus 131.62 83.78 72 5007 99309 110484911
Incorrect route of product administration 130.26 83.78 62 5017 63999 110520221
End stage renal disease 128.10 83.78 45 5034 21428 110562792
Cardiogenic shock 121.19 83.78 57 5022 57281 110526939
Blood calcium increased 119.96 83.78 41 5038 17999 110566221
Multiple organ dysfunction syndrome 117.87 83.78 78 5001 151632 110432588
Chronic obstructive pulmonary disease 117.34 83.78 69 5010 109089 110475131
Bronchopulmonary aspergillosis allergic 114.21 83.78 33 5046 8393 110575827
Gout 111.47 83.78 47 5032 36519 110547701
Ascites 111.28 83.78 63 5016 92745 110491475
Troponin increased 110.29 83.78 44 5035 29722 110554498
Blood test abnormal 108.56 83.78 43 5036 28511 110555709
Intentional product misuse 104.83 83.78 69 5010 132835 110451385
Ulcer 104.03 83.78 47 5032 43069 110541151
Iron deficiency 103.66 83.78 37 5042 18439 110565781
Hyperlipidaemia 102.39 83.78 44 5035 35804 110548416
Hyponatraemia 90.65 83.78 77 5002 217576 110366644
Benign prostatic hyperplasia 85.51 83.78 32 5047 18202 110566018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05XA04 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
ATC G04BA01 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Acidifiers
CHEBI has role CHEBI:173084 ferroptosis inhibitor

Related Drugs by ATC class:

B05XA Electrolyte solutions 18 drugs
calcium chloridecalcium gluconatehydrochloric acidmagnesium chloridemagnesium phosphatemagnesium sulfatepotassium acetatepotassium chloridepotassium lactatepotassium phosphatesodium acetatesodium bicarbonate show all 18 →
G04BA Acidifiers 1 drug
calcium chloride

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cough indication 49727002
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Pulmonary edema contraindication 19242006 DOID:11396
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Agoraphobia contraindication 70691001 DOID:593
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Peripheral edema contraindication 271809000
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Cough Indication

🐶 Veterinary products

ProductApplicantIngredients
Carafen Cough Syrup, Carafen Cough Tablets Zoetis Inc. 2
Carafen Cough Syrup, Carafen Cough Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018575 VUID
N0000146891 NUI
D01139 KEGG_DRUG
4018575 VANDF
C0002615 UMLSCUI
CHEBI:31206 CHEBI
CHEMBL1200939 ChEMBL_ID
DB06767 DRUGBANK_ID
01Q9PC255D UNII
25517 PUBCHEM_CID
712 RXNORM
4182 MMSL
5668 MMSL
d00476 MMSL
000729 NDDF
002276 NDDF
419332007 SNOMEDCT_US
51366003 SNOMEDCT_US
D000643 MESH_DESCRIPTOR_UI
01Q9PC255D INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ecopp portable virus proection HUMAN OTC DRUG LABEL 2 42134-001 GRANULE 0.01 g EXTRACORPOREAL unapproved drug other 7 sections
Yep wake the faith up Ammonia inhalant HUMAN OTC DRUG LABEL 1 85271-7175 INHALANT 17 g RESPIRATORY (INHALATION) unapproved drug other 4 sections
AVIVA Sports Smelling Salts for Athletes HUMAN OTC DRUG LABEL 1 87790-001 POWDER 50 g TOPICAL unapproved drug other 12 sections