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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	1922	21829-25-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: BAY A1040 nifedipine nedipin fedipin	A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Molecular weight: 346.34 Formula: C17H18N2O6 CLOGP: 3.12 LIPINSKI: 0 HAC: 8 HDO: 1 TPSA: 110.45 ALOGS: -4.29 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

BAY A1040
nifedipine
nedipin
fedipin

A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Molecular weight: 346.34
Formula: C17H18N2O6
CLOGP: 3.12
LIPINSKI: 0
HAC: 8
HDO: 1
TPSA: 110.45
ALOGS: -4.29
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O
30	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.01 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	3.71 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	56 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.79 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.04 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.90 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	3.082		High	0.80
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.769		High	0.80
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	75.162	10^-6 cm/s	High	0.80
dh-clint	Dog hepatocyte intrinsic clearance	110.408	uL/min/10^6 cells	High	0.80
dppb	Dog plasma protein binding (% unbound)	7.780	%	High	0.80
fcs-ppb	Fetal calf serum protein binding (% unbound)	9.740	%	High	0.80
herg	hERG pIC50	4.542	pIC50	High	0.80
hh-clint	Human hepatocyte intrinsic clearance	33.266	uL/min/10^6 cells	High	0.80
hlm-clint	Human liver microsomal intrinsic clearance	263.027	uL/min/mg protein	High	0.80
hppb	Human plasma protein binding (% unbound)	5.680	%	High	0.80
kinase-safety-class	ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,STK33,TEK,TTK,ZAP70	38
kinase-selectivity-class	AXL,BRAF,GRK2,PDK4,PIK3CD	5
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	0.780		High	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	2.009		High	0.80
mh-clint	Mouse hepatocyte intrinsic clearance	65.013		High	0.80
mppb	Mouse plasma protein binding (% unbound)	4.190		High	0.80
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	6.324		High	0.80
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	12.150	%	High	0.80
rat-kpuu-brain	Rat brain Kpuu	0.189	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	239.332	uL/min/10^6 cells	High	0.80
rh-fuinc	Rat hepatocyte fraction unbound in incubation	43.870	%	High	0.80
rppb	Rat plasma protein binding (% unbound)	4.260	%	High	0.80
solubility-dd	Solubility at pH 7.4 in DMSO	36.224	uM	High	0.80

Approvals:

Date	Agency	Company	Orphan
Dec. 31, 1981	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	1064.41	10.09	554	73569	38208	90516116
Exposure during pregnancy	387.56	10.09	697	73426	237713	90316611
Premature baby	386.02	10.09	246	73877	24831	90529493
Pre-eclampsia	314.79	10.09	162	73961	10886	90543438
Low birth weight baby	238.91	10.09	128	73995	9339	90544985
Pemphigus	228.27	10.09	9	74114	326855	90227469
Foetal exposure during pregnancy	228.11	10.09	225	73898	42750	90511574
Maternal exposure during pregnancy	225.74	10.09	727	73396	359336	90194988
Glossodynia	202.79	10.09	16	74107	321763	90232561
Alopecia	174.29	10.09	94	74029	494977	90059347
Pericarditis	165.89	10.09	15	74108	270136	90284188
Hypotension	165.41	10.09	613	73510	324784	90229540
Helicobacter infection	159.16	10.09	6	74117	226844	90327480
Wound	154.78	10.09	30	74093	302950	90251374
Systemic lupus erythematosus	145.48	10.09	57	74066	361839	90192485
Duodenal ulcer perforation	145.18	10.09	9	74114	221279	90333045
Renal impairment	144.63	10.09	287	73836	105134	90449190
Arthropathy	141.85	10.09	61	74062	366181	90188143
Foetal growth restriction	139.32	10.09	90	74033	9290	90545034
Neovascularisation	132.57	10.09	50	74073	1580	90552744
Infusion related reaction	128.80	10.09	92	74031	416688	90137636
Caesarean section	125.00	10.09	111	74012	18466	90535858
Blood pressure inadequately controlled	123.87	10.09	72	74051	6152	90548172
Rheumatoid factor positive	122.28	10.09	4	74119	171646	90382678
Blood pressure increased	122.24	10.09	397	73726	196820	90357504
Premature labour	117.02	10.09	93	74030	13283	90541041
Discomfort	113.91	10.09	41	74082	274294	90280030
Synovitis	112.49	10.09	65	74058	329687	90224637
Impaired healing	109.89	10.09	28	74095	234171	90320153
Psoriatic arthropathy	105.79	10.09	28	74095	228307	90326017
Cardiac failure congestive	103.50	10.09	241	73882	98453	90455871
Fibromyalgia	102.03	10.09	22	74101	206247	90348077
Therapeutic product effect decreased	101.58	10.09	50	74073	277521	90276803
Joint swelling	100.87	10.09	160	73963	503140	90051184
Type 2 diabetes mellitus	99.88	10.09	22	74101	203222	90351102
Drug interaction	98.96	10.09	468	73655	275985	90278339
Irritable bowel syndrome	98.87	10.09	24	74099	207424	90346900
Proteinuria	96.76	10.09	107	74016	23184	90531140
Lower respiratory tract infection	95.03	10.09	43	74080	250616	90303708
Hepatic enzyme increased	91.52	10.09	96	74027	360640	90193684
Cerebral infarction	90.09	10.09	110	74013	26486	90527838
Liver injury	84.74	10.09	18	74105	170549	90383775
Anuria	81.25	10.09	79	74044	14739	90539585
Rheumatic fever	80.64	10.09	14	74109	153107	90401217
Blood aldosterone increased	80.21	10.09	21	74102	188	90554136
Oedema peripheral	79.79	10.09	419	73704	257496	90296828
Cardiac failure	78.53	10.09	232	73891	109264	90445060
Pulmonary oedema	77.98	10.09	163	73960	61917	90492407
Paradoxical drug reaction	77.55	10.09	52	74071	5714	90548610
HELLP syndrome	76.60	10.09	31	74092	1186	90553138
Hypersensitivity	76.39	10.09	161	73962	454516	90099808
Blood creatinine increased	73.84	10.09	216	73907	101170	90453154
Abdominal discomfort	73.70	10.09	177	73946	477151	90077173
Wheezing	72.89	10.09	53	74070	238027	90316297
Blister	71.49	10.09	62	74061	254936	90299388
Shock	69.69	10.09	101	74022	28677	90525647
Primary hyperaldosteronism	65.86	10.09	15	74108	69	90554255
Stomatitis	65.36	10.09	77	74046	274621	90279703
Oligohydramnios	64.99	10.09	51	74072	7150	90547174
Dyspnoea exertional	64.57	10.09	166	73957	72122	90482202
Bradycardia	64.31	10.09	182	73941	83665	90470659
Acute kidney injury	63.44	10.09	464	73659	319923	90234401
Scleroderma	62.33	10.09	47	74076	6214	90548110
Sinusitis	61.44	10.09	117	74006	342971	90211353
Blood pressure systolic increased	60.63	10.09	142	73981	58203	90496121
Aplastic anaemia	60.44	10.09	64	74059	13205	90541119
Heart rate decreased	59.78	10.09	134	73989	53371	90500953
Urticaria	59.25	10.09	103	74020	312631	90241693
Contraindicated product administered	59.24	10.09	107	74016	320032	90234292
Swelling	58.81	10.09	163	73960	418895	90135429
Hyperkalaemia	56.81	10.09	148	73975	64816	90489508
Infection	56.06	10.09	134	73989	361960	90192364
Sleep disorder	55.68	10.09	48	74075	197982	90356342
Injury	55.28	10.09	48	74075	197301	90357023
Intestinal angioedema	54.75	10.09	22	74101	826	90553498
Drug intolerance	54.36	10.09	186	73937	447405	90106919
Acute pulmonary oedema	54.26	10.09	52	74071	9528	90544796
Blood pressure systolic abnormal	54.07	10.09	73	74050	19405	90534919
Transfusion	53.90	10.09	69	74054	17419	90536905
Rash	52.81	10.09	408	73715	795692	89758632
Polyhydramnios	52.54	10.09	30	74093	2478	90551846
Blood pressure decreased	52.09	10.09	157	73966	74738	90479586
Blood pressure fluctuation	51.69	10.09	125	73998	52288	90502036
Completed suicide	51.41	10.09	245	73878	144813	90409511
Blood pressure diastolic abnormal	49.93	10.09	71	74052	19810	90534514
Wound infection	49.35	10.09	13	74110	106389	90447935
Premature separation of placenta	48.80	10.09	28	74095	2334	90551990
Cerebrovascular accident	48.49	10.09	215	73908	123318	90431006
General physical health deterioration	48.43	10.09	140	73983	354975	90199349
Hypertensive crisis	48.38	10.09	66	74057	17718	90536606
Treatment failure	48.21	10.09	111	74012	303817	90250507
Mobility decreased	47.10	10.09	83	74040	250651	90303673
Prescribed overdose	47.07	10.09	11	74112	97614	90456710
Ill-defined disorder	47.07	10.09	49	74074	184842	90369482
Renal failure	45.51	10.09	220	73903	130787	90423537
Grip strength decreased	45.50	10.09	10	74113	92566	90461758
Intentional product use issue	45.24	10.09	67	74056	216825	90337499
Pain	44.89	10.09	561	73562	995780	89558544
Hypocalvaria	44.46	10.09	10	74113	43	90554281
Dialysis	43.56	10.09	50	74073	11279	90543045
Eclampsia	43.14	10.09	16	74107	482	90553842
Dyspnoea	41.79	10.09	978	73145	879977	89674347
Mental status changes	41.35	10.09	104	74019	44575	90509749
Compartment syndrome	40.94	10.09	27	74096	2885	90551439
Tubulointerstitial nephritis	40.92	10.09	74	74049	25269	90529055
Wrist deformity	40.69	10.09	28	74095	3210	90551114
Bursitis	40.68	10.09	29	74094	131625	90422699
Bladder prolapse	40.44	10.09	24	74099	2131	90552193
Facet joint syndrome	40.30	10.09	15	74108	98374	90455950
Hypercholesterolaemia	40.30	10.09	16	74107	100876	90453448
Psoriasis	40.10	10.09	37	74086	147717	90406607
Platelet count decreased	39.91	10.09	219	73904	136750	90417574
Phaeochromocytoma	39.81	10.09	16	74107	601	90553723
Gastrointestinal disorder	39.70	10.09	95	74028	256592	90297732
Neonatal respiratory distress syndrome	39.40	10.09	27	74096	3074	90551250
Rectal prolapse	39.31	10.09	24	74099	2243	90552081
Angina unstable	39.00	10.09	38	74085	7105	90547219
Uraemic encephalopathy	38.90	10.09	13	74110	286	90554038
Knee arthroplasty	38.88	10.09	10	74113	83172	90471152
Contusion	38.83	10.09	93	74030	251123	90303201
Pain in jaw	38.60	10.09	106	74017	47879	90506445
Myocardial infarction	38.28	10.09	180	73943	105792	90448532
Product complaint	38.09	10.09	51	74072	13449	90540875
BRASH syndrome	38.09	10.09	22	74101	1857	90552467
Hip arthroplasty	37.93	10.09	8	74115	76200	90478124
Sinobronchitis	37.84	10.09	16	74107	685	90553639
Hypervolaemia	37.67	10.09	83	74040	32674	90521650
Lip dry	37.18	10.09	18	74105	100937	90453387
Product use issue	36.78	10.09	142	73981	329777	90224547
Blood pressure diastolic decreased	36.71	10.09	73	74050	26753	90527571
Drug dispensed to wrong patient	36.57	10.09	13	74110	346	90553978
Tetany	36.43	10.09	24	74099	2560	90551764
Hypergammaglobulinaemia	36.29	10.09	15	74108	606	90553718
Extrapyramidal disorder	36.28	10.09	55	74068	16248	90538076
Blood urea increased	36.04	10.09	78	74045	30335	90523989
Aortic dissection	35.42	10.09	23	74100	2394	90551930
Peripartum cardiomyopathy	34.52	10.09	11	74112	207	90554117
Autoimmune disorder	34.42	10.09	10	74113	76734	90477590
Adverse drug reaction	34.39	10.09	27	74096	116674	90437650
Metabolic acidosis	34.37	10.09	112	74011	55564	90498760
Pulmonary hypertension	34.27	10.09	94	74029	42429	90511895
Maternal condition affecting foetus	33.90	10.09	11	74112	220	90554104
Blood cholesterol increased	33.76	10.09	75	74048	207937	90346387
Scleroderma renal crisis	33.65	10.09	13	74110	439	90553885
Palpitations	33.60	10.09	209	73914	136519	90417805
Cardiac arrest	33.45	10.09	172	73951	104763	90449561
Haemoglobin decreased	33.42	10.09	237	73886	161719	90392605
C-reactive protein abnormal	33.31	10.09	33	74090	127396	90426928
Hepatic function abnormal	33.09	10.09	98	74025	46190	90508134
Respiratory tract inflammation	32.96	10.09	14	74109	606	90553718
Chronic kidney disease	32.83	10.09	103	74020	50088	90504236
Gait inability	32.77	10.09	43	74080	146413	90407911
Preterm premature rupture of membranes	32.70	10.09	19	74104	1622	90552702
Renal artery stenosis	32.60	10.09	21	74102	2156	90552168
Cough	32.54	10.09	452	73671	368510	90185814
Renin decreased	32.38	10.09	9	74114	103	90554221
Patent ductus arteriosus	32.13	10.09	28	74095	4541	90549783
Rheumatoid arthritis	32.08	10.09	170	73953	362444	90191880
Acute myocardial infarction	32.06	10.09	81	74042	34809	90519515
Nodular regenerative hyperplasia	31.66	10.09	14	74109	669	90553655
Injection site reaction	31.57	10.09	18	74105	92062	90462262
Superimposed pre-eclampsia	31.52	10.09	7	74116	28	90554296
Memory impairment	31.29	10.09	72	74051	197172	90357152
Respiratory distress	31.29	10.09	86	74037	38860	90515464
Peripheral vascular disorder	31.05	10.09	32	74091	6399	90547925
Pulmonary arterial hypertension	30.84	10.09	67	74056	26120	90528204
Oxygen saturation decreased	30.73	10.09	171	73952	107312	90447012
Therapeutic product effect incomplete	30.58	10.09	71	74052	193825	90360499
Foetal death	30.31	10.09	58	74065	20665	90533659
Anaemia	30.22	10.09	430	73693	352372	90201952
Hepatic rupture	29.94	10.09	8	74115	78	90554246
Musculoskeletal stiffness	29.71	10.09	133	73990	296399	90257925
Product residue present	29.58	10.09	26	74097	4265	90550059
Foetal distress syndrome	29.44	10.09	18	74105	1687	90552637
Atrial septal defect	29.42	10.09	35	74088	8199	90546125
Nasopharyngitis	29.13	10.09	204	73919	406900	90147424
Altered state of consciousness	28.76	10.09	73	74050	31459	90522865
Lower limb fracture	28.60	10.09	17	74106	84996	90469328
Drug ineffective for unapproved indication	28.45	10.09	119	74004	66525	90487799
Thermal burn	27.97	10.09	31	74092	6731	90547593
Dehydration	27.90	10.09	262	73861	194185	90360139
Confusional state	27.40	10.09	194	73929	386011	90168313
Atrioventricular block first degree	26.89	10.09	34	74089	8477	90545847
Left ventricular hypertrophy	26.86	10.09	29	74094	6115	90548209
Sciatica	26.79	10.09	26	74097	101356	90452968
Adverse event	26.76	10.09	34	74089	117384	90436940
CD30 expression	26.70	10.09	7	74116	63	90554261
Prescribed underdose	26.69	10.09	14	74109	75005	90479319
Diabetic nephropathy	26.65	10.09	17	74106	1717	90552607
Night sweats	26.62	10.09	40	74083	128726	90425598
C-reactive protein increased	26.58	10.09	69	74054	181320	90373004
Nephrogenic systemic fibrosis	26.55	10.09	24	74099	4084	90550240
Hyperaldosteronism	26.39	10.09	10	74113	320	90554004
Weight increased	26.32	10.09	217	73906	417710	90136614
Medication overuse headache	26.31	10.09	16	74107	1485	90552839
Gestational hypertension	26.16	10.09	21	74102	3041	90551283
Paternal exposure during pregnancy	25.96	10.09	10	74113	335	90553989
Urine output decreased	25.92	10.09	41	74082	12562	90541762
Premature rupture of membranes	25.65	10.09	27	74096	5531	90548793
Finger amputation	25.62	10.09	12	74111	656	90553668
Electrocardiogram PR prolongation	25.48	10.09	13	74110	857	90553467
Inflammation	25.36	10.09	69	74054	178523	90375801
Hypertensive emergency	25.13	10.09	18	74105	2199	90552125
Coronary artery disease	24.81	10.09	72	74051	33551	90520773
Foot deformity	24.59	10.09	9	74114	59642	90494682
Renal hypoplasia	24.58	10.09	7	74116	88	90554236
Liver function test increased	24.53	10.09	20	74103	84835	90469489
Lacunar infarction	24.36	10.09	21	74102	3356	90550968
Respiratory failure	24.25	10.09	173	73950	118245	90436079
Endometritis	24.19	10.09	14	74109	1186	90553138
Renal disorder	24.12	10.09	77	74046	37782	90516542
Stillbirth	23.94	10.09	30	74093	7413	90546911
Infrequent bowel movements	23.66	10.09	15	74108	1499	90552825
Coeliac disease	23.65	10.09	4	74119	44606	90509718
Hypertension neonatal	23.63	10.09	5	74118	15	90554309
Bone erosion	23.61	10.09	7	74116	53014	90501310
Allergic sinusitis	23.59	10.09	17	74106	2096	90552228
Foetal exposure timing unspecified	23.41	10.09	10	74113	439	90553885
Cognitive disorder	23.18	10.09	14	74109	69393	90484931
Death	22.84	10.09	511	73612	456040	90098284
Nephrotic syndrome	22.69	10.09	29	74094	7310	90547014
Angina pectoris	22.59	10.09	77	74046	39083	90515241
Frostbite	22.26	10.09	8	74115	220	90554104
Hypoaesthesia	22.20	10.09	158	73965	314052	90240272
Ear infection	22.04	10.09	15	74108	69760	90484564
Joint stiffness	21.82	10.09	19	74104	78023	90476301
Fatigue	21.69	10.09	750	73373	1153273	89401051
Arrhythmia	21.64	10.09	80	74043	42252	90512072
Malignant hypertension	21.50	10.09	13	74110	1194	90553130
Drug titration error	21.21	10.09	13	74110	1224	90553100
Communication disorder	20.95	10.09	19	74104	3247	90551077
Injection site inflammation	20.85	10.09	22	74101	4519	90549805
Gingival hypertrophy	20.76	10.09	16	74107	2184	90552140
Vitamin D decreased	20.65	10.09	36	74087	11943	90542381
Arteriosclerosis	20.54	10.09	34	74089	10819	90543505
Peripheral venous disease	20.50	10.09	23	74100	83898	90470426
Term birth	20.45	10.09	7	74116	166	90554158
Hypovolaemic shock	20.32	10.09	27	74096	7067	90547257
Pleural effusion	20.32	10.09	159	73964	111832	90442492
Exostosis	20.29	10.09	9	74114	53125	90501199
Foetal hypokinesia	20.22	10.09	10	74113	617	90553707
Barotrauma	20.07	10.09	7	74116	176	90554148
Exposure via breast milk	20.04	10.09	16	74107	2299	90552025
Fluid retention	19.99	10.09	132	73991	87959	90466365
Atrioventricular block	19.99	10.09	30	74093	8785	90545539
Injection site erythema	19.97	10.09	31	74092	98471	90455853
Hypoxia	19.91	10.09	114	74009	72285	90482039
Road traffic accident	19.86	10.09	36	74087	107590	90446734
Drug abuse	19.65	10.09	23	74100	82324	90472000
Joint dislocation	19.64	10.09	6	74117	44576	90509748
Nail disorder	19.61	10.09	12	74111	59055	90495269
Cardiomegaly	19.59	10.09	46	74077	18879	90535445
Joint contracture	19.56	10.09	14	74109	1708	90552616
Delusion	19.35	10.09	38	74085	13802	90540522
Renin increased	19.22	10.09	7	74116	200	90554124
Hypoperfusion	19.12	10.09	14	74109	1770	90552554
Product quality issue	19.10	10.09	22	74101	79303	90475021
Neutropenia	19.01	10.09	107	74016	224797	90329527
Pulmonary fibrosis	18.92	10.09	37	74086	107466	90446858
Laryngitis	18.76	10.09	9	74114	50744	90503580
Aortic valve incompetence	18.65	10.09	25	74098	6599	90547725
Use of accessory respiratory muscles	18.65	10.09	8	74115	355	90553969
Hypermagnesaemia	18.59	10.09	12	74111	1237	90553087
Oral herpes	18.53	10.09	65	74058	33459	90520865
Hypertensive encephalopathy	18.47	10.09	10	74113	745	90553579
Hyperuricaemia	18.37	10.09	25	74098	6694	90547630
Transient ischaemic attack	18.35	10.09	77	74046	43099	90511225
Vascular resistance systemic increased	18.33	10.09	3	74120	0	90554324
Heart rate increased	18.17	10.09	156	73967	112746	90441578
Heliotrope rash	18.08	10.09	7	74116	238	90554086
Renal impairment neonatal	18.01	10.09	5	74118	57	90554267
Bradycardia foetal	17.99	10.09	9	74114	569	90553755
Transferrin decreased	17.94	10.09	8	74115	390	90553934
Hypoglycaemia	17.93	10.09	108	74015	69740	90484584
Urinary tract infection	17.85	10.09	350	73773	305282	90249042
Haemoperitoneum	17.84	10.09	18	74105	3510	90550814
Osteoarthritis	17.72	10.09	91	74032	195639	90358685
Amnesia	17.70	10.09	39	74084	108466	90445858
Hypoproteinaemia	17.69	10.09	17	74106	3125	90551199
Colitis ulcerative	17.68	10.09	14	74109	60252	90494072
Syncope	17.67	10.09	176	73947	132487	90421837
Feeling cold	17.63	10.09	56	74067	27409	90526915
Dry mouth	17.56	10.09	84	74039	183975	90370349
Epilepsy	17.51	10.09	25	74098	82181	90472143
Arthralgia	17.49	10.09	494	73629	778028	89776296
Platelet transfusion	17.26	10.09	11	74112	1109	90553215
Myocardial depression	17.22	10.09	9	74114	624	90553700
Rubber sensitivity	17.22	10.09	16	74107	2821	90551503
Incorrect route of product administration	17.20	10.09	10	74113	50616	90503708
Skin induration	17.15	10.09	17	74106	3245	90551079
Pseudolymphoma	17.13	10.09	9	74114	631	90553693
Hepatic cirrhosis	16.97	10.09	16	74107	63237	90491087
Macular degeneration	16.93	10.09	5	74118	37965	90516359
Toxicity to various agents	16.93	10.09	330	73793	287516	90266808
Pancreatic neuroendocrine tumour metastatic	16.87	10.09	5	74118	73	90554251
Hypocalcaemia	16.81	10.09	74	74049	42294	90512030
Drug tolerance decreased	16.77	10.09	3	74120	32127	90522197
Blood lactate dehydrogenase increased	16.76	10.09	53	74070	25879	90528445
Red blood cell sedimentation rate increased	16.74	10.09	26	74097	82569	90471755
Joint range of motion decreased	16.68	10.09	56	74067	135587	90418737
Laboratory test interference	16.61	10.09	9	74114	671	90553653
Ventricular hypertrophy	16.60	10.09	17	74106	3374	90550950
Abdominal pain upper	16.56	10.09	183	73940	332491	90221833
End stage renal disease	16.42	10.09	27	74096	8544	90545780
Myalgia	16.42	10.09	217	73906	174908	90379416
Tachycardia	16.32	10.09	199	73924	157474	90396850
Peritonitis	16.31	10.09	44	74079	19661	90534663
Poikiloderma	16.31	10.09	7	74116	311	90554013
Chillblains	16.27	10.09	7	74116	313	90554011
Back injury	16.14	10.09	9	74114	46613	90507711
Haemodialysis	16.02	10.09	27	74096	8720	90545604
Taste disorder	16.01	10.09	16	74107	61530	90492794
Renal tubular dysfunction	16.00	10.09	8	74115	505	90553819
Atypical haemolytic uraemic syndrome	15.94	10.09	10	74113	981	90553343
Pericardial effusion	15.90	10.09	66	74057	36767	90517557
Skin hypertrophy	15.71	10.09	17	74106	3593	90550731
Hyperplasia adrenal	15.68	10.09	4	74119	32	90554292
Inappropriate antidiuretic hormone secretion	15.60	10.09	43	74080	19462	90534862
Asthma	15.56	10.09	125	73998	242035	90312289
Acute coronary syndrome	15.49	10.09	30	74093	10783	90543541
Renal injury	15.39	10.09	29	74094	10214	90544110
Atrial fibrillation	15.32	10.09	172	73951	133439	90420885
Paternal exposure before pregnancy	15.27	10.09	5	74118	103	90554221
Umbilical cord vascular disorder	15.18	10.09	5	74118	105	90554219
Product substitution error	15.16	10.09	4	74119	37	90554287
Adverse reaction	15.03	10.09	3	74120	29709	90524615
Hypoglycaemia neonatal	14.80	10.09	10	74113	1112	90553212
Alanine aminotransferase increased	14.80	10.09	155	73968	118183	90436141
Azotaemia	14.78	10.09	20	74103	5328	90548996
Antibody test positive	14.66	10.09	15	74108	2974	90551350
Haematuria	14.61	10.09	62	74061	34875	90519449
Stevens-Johnson syndrome	14.58	10.09	55	74068	29321	90525003
Frequent bowel movements	14.58	10.09	15	74108	56920	90497404
Hypoaesthesia teeth	14.54	10.09	4	74119	44	90554280
Brain natriuretic peptide increased	14.43	10.09	21	74102	5984	90548340
Renal atrophy	14.37	10.09	12	74111	1836	90552488
Human chorionic gonadotropin positive	14.37	10.09	4	74119	46	90554278
Histiocytic necrotising lymphadenitis	14.37	10.09	4	74119	46	90554278
Plagiocephaly	14.32	10.09	5	74118	126	90554198
Hypertension	14.30	10.09	482	73641	457050	90097274
Skin tightness	14.29	10.09	18	74105	4470	90549854
Threatened labour	14.29	10.09	9	74114	889	90553435
Cervical incompetence	14.25	10.09	8	74115	640	90553684
Cerebral haemorrhage	14.23	10.09	61	74062	34461	90519863
Lactic acidosis	14.23	10.09	80	74043	50383	90503941
Sinus bradycardia	14.18	10.09	38	74085	16914	90537410
Underdose	14.10	10.09	14	74109	54003	90500321
Immunodeficiency	14.05	10.09	9	74114	43225	90511099
Gastroenteritis	13.92	10.09	54	74069	29175	90525149
Foetal heart rate deceleration abnormality	13.90	10.09	8	74115	671	90553653
Hyperglycaemia	13.84	10.09	80	74043	50890	90503434
Pulmonary artery stenosis congenital	13.77	10.09	7	74116	458	90553866
Iron binding capacity total decreased	13.76	10.09	7	74116	459	90553865
Ascites	13.67	10.09	76	74047	47664	90506660
Sleep disorder due to a general medical condition	13.62	10.09	10	74113	44728	90509596
Contraindicated product prescribed	13.60	10.09	11	74112	1611	90552713
Peripheral coldness	13.55	10.09	33	74090	13859	90540465
Tricuspid valve incompetence	13.49	10.09	37	74086	16694	90537630
Muscle spasticity	13.46	10.09	6	74117	35316	90519008
Oliguria	13.46	10.09	28	74095	10596	90543728
Aspartate aminotransferase increased	13.43	10.09	136	73987	102801	90451523
Large intestine polyp	13.40	10.09	26	74097	9360	90544964
Blood albumin decreased	13.39	10.09	37	74086	16766	90537558
Carotid artery disease	13.39	10.09	11	74112	1646	90552678
Psychomotor retardation	13.37	10.09	18	74105	4771	90549553
Cholecystitis acute	13.36	10.09	26	74097	9378	90544946
Neonatal hyponatraemia	13.34	10.09	4	74119	61	90554263
Jaundice neonatal	13.32	10.09	9	74114	1001	90553323
Limb injury	13.24	10.09	56	74067	31452	90522872
Cortisol increased	13.21	10.09	7	74116	499	90553825
Multiple sclerosis relapse	13.15	10.09	14	74109	52291	90502033
Anaemia of pregnancy	13.14	10.09	5	74118	162	90554162
Electrocardiogram abnormal	12.88	10.09	27	74096	10271	90544053
Stress	12.85	10.09	112	74011	81283	90473041
Amniotic cavity infection	12.84	10.09	10	74113	1386	90552938
Intentional self-injury	12.83	10.09	4	74119	29330	90524994
Blood corticotrophin decreased	12.76	10.09	7	74116	535	90553789
Hypoalbuminaemia	12.66	10.09	35	74088	15862	90538462
Haemodynamic instability	12.66	10.09	29	74094	11710	90542614
Gastrointestinal haemorrhage	12.63	10.09	121	74002	90127	90464197
Myocardial ischaemia	12.62	10.09	32	74091	13782	90540542
Right ventricular hypertrophy	12.53	10.09	8	74115	809	90553515
Intentional product misuse	12.43	10.09	35	74088	89569	90464755
Loss of consciousness	12.41	10.09	172	73951	140066	90414258
Maternal drugs affecting foetus	12.34	10.09	18	74105	5137	90549187
Spinal cord infarction	12.32	10.09	6	74117	358	90553966
Neuromuscular blockade	12.29	10.09	6	74117	360	90553964
Sepsis	12.26	10.09	211	73912	179603	90374721
Nephropathy toxic	12.23	10.09	30	74093	12658	90541666
Right ventricular failure	12.18	10.09	39	74084	19166	90535158
Cardiac disorder	12.17	10.09	84	74039	56788	90497536
Blood potassium increased	12.14	10.09	41	74082	20708	90533616
Blood alkaline phosphatase increased	12.12	10.09	74	74049	48005	90506319
Foetal exposure during delivery	12.07	10.09	6	74117	374	90553950
Ischaemia	11.98	10.09	18	74105	5277	90549047
Finger deformity	11.91	10.09	6	74117	32891	90521433
Ear pain	11.85	10.09	18	74105	57684	90496640
Onychomycosis	11.85	10.09	8	74115	37368	90516956
Lung disorder	11.76	10.09	73	74050	149810	90404514
Systemic scleroderma	11.71	10.09	10	74113	1579	90552745
Haemodialysis complication	11.65	10.09	5	74118	222	90554102
Hydronephrosis	11.61	10.09	29	74094	12373	90541951
Pancreatitis haemorrhagic	11.59	10.09	7	74116	642	90553682
Haematocrit decreased	11.59	10.09	66	74057	41766	90512558
Maternal exposure during delivery	11.58	10.09	15	74108	3831	90550493
Tongue oedema	11.57	10.09	18	74105	5436	90548888
Therapy partial responder	11.55	10.09	42	74081	22001	90532323
Retroperitoneal haematoma	11.52	10.09	14	74109	3354	90550970
Interstitial lung disease	11.48	10.09	104	74019	76301	90478023
Ductus arteriosus premature closure	11.45	10.09	6	74117	418	90553906
Thymic cyst	11.45	10.09	4	74119	101	90554223
Leukocytosis	11.45	10.09	53	74070	30937	90523387
Sprue-like enteropathy	11.41	10.09	8	74115	945	90553379
Obesity	11.36	10.09	46	74077	105461	90448863
Renal-limited thrombotic microangiopathy	11.33	10.09	5	74118	238	90554086
Small for dates baby	11.29	10.09	17	74106	4990	90549334
Cardiac failure acute	11.28	10.09	28	74095	11901	90542423
Drug eruption	11.25	10.09	58	74065	35349	90518975
Mallory-Weiss syndrome	11.25	10.09	10	74113	1665	90552659
Congenital hypothyroidism	11.21	10.09	5	74118	244	90554080
Renal transplant	11.18	10.09	10	74113	1678	90552646
Arteriovenous fistula operation	11.09	10.09	5	74118	250	90554074
Pyuria	11.06	10.09	11	74112	2108	90552216
Mitral valve incompetence	11.04	10.09	42	74081	22482	90531842
Peptic ulcer perforation	11.02	10.09	6	74117	452	90553872
Induced labour	11.01	10.09	8	74115	1000	90553324
Microvillous inclusion disease	10.99	10.09	3	74120	32	90554292
Essential hypertension	10.92	10.09	19	74104	6296	90548028
Erythema migrans	10.90	10.09	3	74120	33	90554291
Peritonitis bacterial	10.88	10.09	17	74106	5154	90549170
Hypokalaemia	10.88	10.09	159	73964	130957	90423367
Blood pressure diastolic increased	10.87	10.09	29	74094	12877	90541447
Chronic sinusitis	10.86	10.09	3	74120	23799	90530525
Biopsy kidney abnormal	10.82	10.09	3	74120	34	90554290
Ulcer haemorrhage	10.80	10.09	4	74119	26317	90528007
Dermatophytosis of nail	10.77	10.09	4	74119	121	90554203
Walking aid user	10.73	10.09	8	74115	35498	90518826
Peritoneal dialysis	10.71	10.09	6	74117	478	90553846
Pulseless electrical activity	10.69	10.09	23	74100	8909	90545415
Thalamus haemorrhage	10.63	10.09	7	74116	746	90553578
Hyperparathyroidism secondary	10.63	10.09	10	74113	1791	90552533
Therapy change	10.62	10.09	22	74101	8300	90546024
Ileal ulcer	10.61	10.09	8	74115	1058	90553266
Hypertrophic cardiomyopathy	10.60	10.09	11	74112	2217	90552107
Generalised oedema	10.58	10.09	37	74086	19016	90535308
Nodal rhythm	10.55	10.09	10	74113	1808	90552516
Autoimmune thyroiditis	10.54	10.09	18	74105	5875	90548449
Pemphigoid	10.52	10.09	23	74100	9003	90545321
Tuberculin test positive	10.40	10.09	14	74109	3711	90550613
Large intestine benign neoplasm	10.33	10.09	4	74119	136	90554188
Enterocolitis	10.32	10.09	25	74098	10465	90543859
Food allergy	10.24	10.09	4	74119	25474	90528850
Constipation	10.22	10.09	301	73822	280094	90274230
Respiratory depression	10.22	10.09	32	74091	15543	90538781
Pneumonia	10.21	10.09	628	73495	637431	89916893
Accidental overdose	10.18	10.09	48	74075	28225	90526099
Migraine	10.17	10.09	103	74020	190289	90364035

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature baby	309.18	10.35	242	51108	22911	42547074
Low birth weight baby	211.26	10.35	138	51212	9817	42560168
Foetal exposure during pregnancy	187.44	10.35	257	51093	47054	42522931
Gingival hypertrophy	148.61	10.35	68	51282	2371	42567614
Photodermatosis	104.51	10.35	38	51312	722	42569263
Solar lentigo	103.48	10.35	36	51314	598	42569387
Off label use	103.08	10.35	409	50941	637926	41932059
Dysplastic naevus	96.85	10.35	35	51315	653	42569332
Drug ineffective	87.58	10.35	427	50923	629770	41940215
Shock	87.55	10.35	139	51211	28982	42541003
Cerebral infarction	80.57	10.35	139	51211	31030	42538955
Renal impairment	77.55	10.35	300	51050	109928	42460057
Polydactyly	73.91	10.35	34	51316	1200	42568785
Foetal growth restriction	72.16	10.35	56	51294	5227	42564758
Completed suicide	70.69	10.35	266	51084	96199	42473786
Bradycardia	68.78	10.35	243	51107	85241	42484744
Hyperkalaemia	63.26	10.35	227	51123	80231	42489754
Drug abuse	62.49	10.35	24	51326	104747	42465238
Blood creatinine increased	58.47	10.35	275	51075	109728	42460257
Neutropenia	57.33	10.35	95	51255	199336	42370649
BRASH syndrome	55.90	10.35	32	51318	1793	42568192
Kidney transplant rejection	53.55	10.35	59	51291	8624	42561361
Blood urea increased	51.78	10.35	119	51231	32674	42537311
Proteinuria	49.85	10.35	95	51255	22888	42547097
Aplastic anaemia	48.58	10.35	67	51283	12317	42557668
Phospholipidosis	47.58	10.35	12	51338	58	42569927
Atrioventricular septal defect	46.77	10.35	16	51334	252	42569733
Protein urine present	45.81	10.35	45	51305	5756	42564229
Drug interaction	44.77	10.35	505	50845	266494	42303491
Cardiac failure congestive	44.01	10.35	212	51138	85390	42484595
Pulse pressure increased	43.89	10.35	9	51341	12	42569973
Dandy-Walker syndrome	42.37	10.35	15	51335	263	42569722
Blood pressure increased	41.75	10.35	237	51113	101691	42468294
Trisomy 21	41.12	10.35	18	51332	564	42569421
Hepatic function abnormal	39.24	10.35	144	51206	51423	42518562
Hypotension	38.19	10.35	476	50874	257155	42312830
Bezoar	38.08	10.35	22	51328	1254	42568731
Actinic keratosis	36.92	10.35	38	51312	5138	42564847
Pulmonary hypertension	36.62	10.35	85	51265	23484	42546501
Neurodevelopmental disorder	35.09	10.35	15	51335	443	42569542
Product use in unapproved indication	35.00	10.35	110	51240	184346	42385639
Chronic kidney disease	34.34	10.35	130	51220	47111	42522874
Macrocephaly	34.21	10.35	15	51335	472	42569513
Blood pressure decreased	34.07	10.35	150	51200	58182	42511803
Diabetic hyperosmolar coma	33.10	10.35	15	51335	511	42569474
Speech disorder developmental	32.91	10.35	25	51325	2260	42567725
Telangiectasia	32.26	10.35	19	51331	1123	42568862
Thrombotic cerebral infarction	31.51	10.35	14	51336	455	42569530
Oesophageal obstruction	31.17	10.35	15	51335	587	42569398
Febrile neutropenia	31.00	10.35	117	51233	185586	42384399
Interstitial lung disease	29.89	10.35	179	51171	78283	42491702
Atrioventricular block complete	29.77	10.35	51	51299	11313	42558672
Cardiac arrest	29.47	10.35	229	51121	109091	42460894
Prinzmetal angina	29.24	10.35	19	51331	1338	42568647
Oedema	29.07	10.35	132	51218	51869	42518116
Congenital central nervous system anomaly	28.92	10.35	15	51335	690	42569295
Hypertension	27.39	10.35	315	51035	166889	42403096
Foetal exposure timing unspecified	27.22	10.35	11	51339	281	42569704
Myocardial infarction	27.18	10.35	248	51102	123761	42446224
Aplasia pure red cell	26.96	10.35	38	51312	7128	42562857
Pre-eclampsia	26.49	10.35	7	51343	42	42569943
Acute kidney injury	26.34	10.35	603	50747	366734	42203251
Hyperuricaemia	25.62	10.35	43	51307	9381	42560604
Incision site pain	25.62	10.35	20	51330	1883	42568102
Endoscopy upper gastrointestinal tract abnormal	24.97	10.35	7	51343	54	42569931
Acute myocardial infarction	24.96	10.35	137	51213	58028	42511957
Exposure via breast milk	24.94	10.35	22	51328	2455	42567530
Hypotonic-hyporesponsive episode	24.91	10.35	6	51344	23	42569962
Drug dependence	24.69	10.35	3	51347	29091	42540894
Product residue present	24.24	10.35	23	51327	2818	42567167
Therapeutic product effect incomplete	24.09	10.35	30	51320	70909	42499076
Intentional overdose	23.99	10.35	124	51226	51332	42518653
Oedema peripheral	23.47	10.35	259	51091	135817	42434168
Lacunar infarction	23.37	10.35	24	51326	3236	42566749
Squamous cell carcinoma of skin	23.28	10.35	49	51301	12677	42557308
Hypertensive crisis	23.14	10.35	43	51307	10163	42559822
Haemodilution	22.99	10.35	6	51344	34	42569951
Systemic scleroderma	22.88	10.35	12	51338	565	42569420
Thrombocytopenia	22.85	10.35	135	51215	190144	42379841
Hypertensive emergency	22.78	10.35	16	51334	1281	42568704
Gene mutation	22.43	10.35	18	51332	1763	42568222
Drug level increased	22.36	10.35	76	51274	26124	42543861
Lupus-like syndrome	22.22	10.35	23	51327	3131	42566854
Blood pressure inadequately controlled	22.18	10.35	22	51328	2846	42567139
Patent ductus arteriosus	22.09	10.35	24	51326	3452	42566533
Pemphigoid	21.96	10.35	45	51305	11422	42558563
Chronic allograft nephropathy	21.96	10.35	17	51333	1581	42568404
Product dose omission issue	21.60	10.35	104	51246	154261	42415724
Renal failure	21.43	10.35	266	51084	143460	42426525
Periodontitis	21.00	10.35	19	51331	2192	42567793
Treatment failure	20.73	10.35	27	51323	62597	42507388
Anti-erythropoietin antibody positive	20.62	10.35	13	51337	869	42569116
Renal disorder	20.44	10.35	79	51271	28901	42541084
Nephrogenic anaemia	20.31	10.35	20	51330	2566	42567419
Hyperinsulinaemia	20.19	10.35	7	51343	115	42569870
Procedural hypertension	20.02	10.35	6	51344	60	42569925
Malignant hypertension	19.72	10.35	12	51338	753	42569232
Death	19.57	10.35	426	50924	470759	42099226
Pyelocaliectasis	19.38	10.35	15	51335	1394	42568591
Pulmonary oedema	19.31	10.35	120	51230	53152	42516833
Glomerular filtration rate decreased	19.16	10.35	53	51297	16298	42553687
Congenital cystic lung	19.15	10.35	8	51342	223	42569762
Crepitations	19.08	10.35	22	51328	3379	42566606
HIV associated nephropathy	18.87	10.35	9	51341	345	42569640
Azotaemia	18.73	10.35	29	51321	5915	42564070
Cutaneous lupus erythematosus	18.61	10.35	12	51338	834	42569151
Neonatal respiratory distress syndrome	18.58	10.35	25	51325	4488	42565497
Nephrogenic systemic fibrosis	18.56	10.35	22	51328	3479	42566506
Removal of internal fixation	18.19	10.35	4	51346	9	42569976
Neonatal respiratory failure	18.09	10.35	9	51341	379	42569606
Joint range of motion decreased	18.00	10.35	33	51317	7720	42562265
Supernumerary nipple	17.90	10.35	5	51345	38	42569947
Maternal exposure during pregnancy	17.86	10.35	31	51319	6947	42563038
Photosensitivity reaction	17.78	10.35	44	51306	12658	42557327
Putamen haemorrhage	17.59	10.35	8	51342	275	42569710
Myocardial ischaemia	17.39	10.35	54	51296	17708	42552277
Attention deficit hyperactivity disorder	17.26	10.35	20	51330	3088	42566897
Retinopathy of prematurity	17.07	10.35	7	51343	186	42569799
Mixed connective tissue disease	17.06	10.35	5	51345	46	42569939
Loss of personal independence in daily activities	16.98	10.35	21	51329	49795	42520190
Vomiting	16.74	10.35	247	51103	289476	42280509
Pemphigus	16.66	10.35	16	51334	1990	42567995
Cell marker increased	16.61	10.35	9	51341	453	42569532
Intentional product use issue	16.48	10.35	39	51311	71794	42498191
Blood pressure systolic	16.47	10.35	4	51346	16	42569969
Atrioventricular block	16.41	10.35	36	51314	9579	42560406
Agitation	16.34	10.35	33	51317	64281	42505704
Rickets	16.26	10.35	5	51345	55	42569930
Tubulointerstitial nephritis	16.10	10.35	78	51272	31470	42538515
Ventricular septal defect	16.06	10.35	23	51327	4376	42565609
Congenital pulmonary valve atresia	16.02	10.35	5	51345	58	42569927
Caesarean section	16.00	10.35	16	51334	2090	42567895
Hypergastrinaemia	16	10.35	7	51343	219	42569766
Brain stem infarction	15.82	10.35	13	51337	1317	42568668
Exposure during pregnancy	15.73	10.35	33	51317	8515	42561470
Apnoeic attack	15.66	10.35	9	51341	508	42569477
Disease progression	15.65	10.35	105	51245	143551	42426434
Jaundice neonatal	15.55	10.35	16	51334	2163	42567822
Infantile apnoea	15.42	10.35	12	51338	1124	42568861
Skin tightness	15.36	10.35	16	51334	2194	42567791
Angina unstable	15.34	10.35	39	51311	11409	42558576
Post procedural urine leak	15.24	10.35	6	51344	143	42569842
Neuropathy peripheral	15.20	10.35	67	51283	101786	42468199
Vertebral artery stenosis	15.12	10.35	6	51344	146	42569839
Intestinal pseudo-obstruction	15.09	10.35	16	51334	2239	42567746
Polyhydramnios	14.98	10.35	7	51343	256	42569729
Cytokine release syndrome	14.94	10.35	19	51331	44508	42525477
Bronchopulmonary dysplasia	14.86	10.35	10	51340	747	42569238
Adverse drug reaction	14.73	10.35	14	51336	37420	42532565
Metabolic acidosis	14.72	10.35	110	51240	51748	42518237
Abdominal symptom	14.66	10.35	9	51341	574	42569411
Diabetic nephropathy	14.59	10.35	16	51334	2325	42567660
Pulmonary eosinophilia	14.52	10.35	7	51343	275	42569710
Drug intolerance	14.51	10.35	49	51301	80375	42489610
Cerebrovascular insufficiency	14.49	10.35	4	51346	29	42569956
Immunosuppressant drug level increased	14.41	10.35	30	51320	7701	42562284
Lymphocyte count decreased	14.37	10.35	69	51281	27740	42542245
Cardiac failure	14.33	10.35	194	51156	106662	42463323
Chorioretinopathy	14.23	10.35	13	51337	1518	42568467
Cardiac failure chronic	14.23	10.35	34	51316	9567	42560418
Aortic dissection	14.17	10.35	18	51332	3054	42566931
Eating disorder symptom	14.03	10.35	4	51346	33	42569952
Altered state of consciousness	13.98	10.35	71	51279	29188	42540797
Pituitary tumour recurrent	13.95	10.35	5	51345	91	42569894
Cerebral hyperperfusion syndrome	13.95	10.35	5	51345	91	42569894
Maternal drugs affecting foetus	13.91	10.35	20	51330	3819	42566166
Suspected suicide	13.90	10.35	26	51324	6173	42563812
Meningitis staphylococcal	13.80	10.35	5	51345	94	42569891
Angina pectoris	13.79	10.35	77	51273	32819	42537166
Sedation	13.72	10.35	10	51340	30465	42539520
Sepsis	13.66	10.35	164	51186	199170	42370815
Congenital hearing disorder	13.65	10.35	5	51345	97	42569888
Red blood cells urine positive	13.58	10.35	14	51336	1896	42568089
Blood pressure systolic increased	13.45	10.35	68	51282	27900	42542085
Naevus flammeus	13.39	10.35	6	51344	199	42569786
Nausea	13.37	10.35	370	50980	396429	42173556
Hydrocele male infected	13.35	10.35	4	51346	40	42569945
Gastrointestinal stromal tumour	13.28	10.35	11	51339	1127	42568858
Sclerodactylia	13.26	10.35	4	51346	41	42569944
Drug ineffective for unapproved indication	13.22	10.35	22	51328	46141	42523844
Depressed level of consciousness	13.19	10.35	101	51249	47869	42522116
Condition aggravated	13.14	10.35	228	51122	260526	42309459
Oesophageal haemorrhage	13.13	10.35	12	51338	1402	42568583
Orthostatic hypotension	13.11	10.35	72	51278	30498	42539487
Tonsillar hypertrophy	13.06	10.35	10	51340	915	42569070
Renal artery stenosis	13.02	10.35	15	51335	2302	42567683
Congenital vesicoureteric reflux	13.00	10.35	4	51346	44	42569941
Haemoglobin decreased	12.97	10.35	228	51122	132243	42437742
Hyphaema	12.92	10.35	9	51341	711	42569274
Sleep disorder	12.80	10.35	24	51326	48071	42521914
Bradycardia foetal	12.79	10.35	7	51343	359	42569626
Pulmonary embolism	12.74	10.35	88	51262	119524	42450461
Complications of transplanted kidney	12.71	10.35	23	51327	5327	42564658
Aggression	12.69	10.35	21	51329	44142	42525843
Apgar score low	12.68	10.35	10	51340	955	42569030
Generalised oedema	12.66	10.35	44	51306	15292	42554693
Psychotic disorder	12.61	10.35	10	51340	29198	42540787
Wrong technique in product usage process	12.51	10.35	20	51330	42615	42527370
Anti-neutrophil cytoplasmic antibody positive vasculitis	12.34	10.35	12	51338	1516	42568469
Hyperparathyroidism tertiary	12.26	10.35	4	51346	54	42569931
Dialysis	12.26	10.35	37	51313	11949	42558036
Renal failure neonatal	12.22	10.35	5	51345	132	42569853
Postrenal failure	12.17	10.35	8	51342	575	42569410
General physical health deterioration	12.13	10.35	120	51230	151126	42418859
Peripheral arterial occlusive disease	12.12	10.35	26	51324	6812	42563173
Transplant rejection	12.11	10.35	40	51310	13548	42556437
Cerebrovascular accident	12.06	10.35	174	51176	96986	42472999
Fatigue	12.05	10.35	417	50933	435224	42134761
Anaemia neonatal	12.02	10.35	7	51343	405	42569580
Injection site pain	12.01	10.35	33	51317	57765	42512220
Acute lung injury	11.94	10.35	12	51338	1577	42568408
Blood albumin increased	11.81	10.35	9	51341	818	42569167
Hypoglycaemia	11.75	10.35	117	51233	59737	42510248
Palatal swelling	11.75	10.35	4	51346	62	42569923
Scleroderma renal crisis	11.71	10.35	7	51343	425	42569560
Hepatocellular injury	11.70	10.35	7	51343	23671	42546314
Poor feeding infant	11.66	10.35	9	51341	833	42569152
Premature delivery	11.66	10.35	5	51345	149	42569836
Ventricular extrasystoles	11.56	10.35	39	51311	13351	42556634
Dyslalia	11.54	10.35	8	51342	627	42569358
Low density lipoprotein increased	11.44	10.35	22	51328	5333	42564652
Pancytopenia	11.39	10.35	89	51261	117654	42452331
Cardiac cirrhosis	11.30	10.35	4	51346	70	42569915
Deep vein thrombosis	11.25	10.35	51	51299	76906	42493079
Leukopenia	11.25	10.35	49	51301	74697	42495288
Hypokalaemia	11.22	10.35	134	51216	71587	42498398
Hypersensitivity	11.16	10.35	47	51303	72323	42497662
Neonatal cholestasis	11.15	10.35	4	51346	73	42569912
Hydrops foetalis	11.09	10.35	9	51341	896	42569089
Immobilisation syndrome	11.09	10.35	7	51343	469	42569516
Hypertensive encephalopathy	11.01	10.35	7	51343	475	42569510
Intentional product misuse	10.97	10.35	38	51312	61862	42508123
Incorrect route of product administration	10.91	10.35	8	51342	24297	42545688
Gastric cancer	10.84	10.35	25	51325	6878	42563107
Full blood count abnormal	10.82	10.35	12	51338	29864	42540121
Peritonitis bacterial	10.81	10.35	25	51325	6890	42563095
Skin hypertrophy	10.80	10.35	15	51335	2774	42567211
Hypertensive nephropathy	10.79	10.35	7	51343	492	42569493
Hypermagnesaemia	10.75	10.35	6	51344	320	42569665
Atrial septal defect	10.63	10.35	27	51323	7892	42562093
Urticaria pigmentosa	10.61	10.35	3	51347	24	42569961
Gastric ileus	10.61	10.35	3	51347	24	42569961
Neonatal respiratory distress	10.58	10.35	9	51341	956	42569029
Paralysis	10.56	10.35	25	51325	6995	42562990
Decreased appetite	10.55	10.35	306	51044	192831	42377154
Arthralgia	10.48	10.35	179	51171	205059	42364926
Arteriovenous fistula thrombosis	10.40	10.35	6	51344	341	42569644
Restrictive cardiomyopathy	10.35	10.35	8	51342	742	42569243

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	826.52	9.80	460	107885	30172	110450782
Exposure during pregnancy	283.81	9.80	553	107792	166871	110314083
Pre-eclampsia	244.49	9.80	134	108211	8516	110472438
Renal impairment	217.28	9.80	533	107812	187912	110293042
Hypotension	179.36	9.80	997	107348	522852	109958102
Cerebral infarction	175.95	9.80	235	108110	51603	110429351
Maternal exposure during pregnancy	164.10	9.80	586	107759	254297	110226657
Gingival hypertrophy	162.15	9.80	81	108264	4250	110476704
Drug interaction	161.33	9.80	937	107408	499246	109981708
Shock	160.94	9.80	229	108116	53359	110427595
Glossodynia	152.36	9.80	19	108326	221985	110258969
Pericarditis	147.38	9.80	20	108325	219094	110261860
Folliculitis	145.51	9.80	4	108341	167649	110313305
Cardiac failure congestive	145.11	9.80	399	107946	150601	110330353
Alopecia	144.97	9.80	89	108256	364664	110116290
Pemphigus	143.34	9.80	20	108325	214550	110266404
Helicobacter infection	139.51	9.80	10	108335	181867	110299087
Bradycardia	137.76	9.80	399	107946	155118	110325836
Completed suicide	137.43	9.80	535	107810	241846	110239108
Wound	136.78	9.80	31	108314	234406	110246548
Duodenal ulcer perforation	135.65	9.80	10	108335	177690	110303264
Blood creatinine increased	132.99	9.80	438	107907	182451	110298503
Proteinuria	132.12	9.80	179	108166	39839	110441115
Hyperkalaemia	129.65	9.80	358	107987	135438	110345516
Muscle injury	123.55	9.80	3	108342	140804	110340150
Neovascularisation	120.73	9.80	50	108295	1687	110479267
Blood pressure increased	120.38	9.80	537	107808	257836	110223118
Arthropathy	114.43	9.80	70	108275	287452	110193502
Psoriatic arthropathy	112.82	9.80	27	108318	196734	110284220
Impaired healing	108.92	9.80	29	108316	196688	110284266
Rheumatoid factor positive	107.79	9.80	5	108340	131635	110349319
Fibromyalgia	105.04	9.80	20	108325	170889	110310065
Joint swelling	103.97	9.80	171	108174	442674	110038280
Photodermatosis	102.36	9.80	39	108306	1052	110479902
Synovitis	101.94	9.80	72	108273	274020	110206934
Premature labour	101.74	9.80	79	108266	9093	110471861
Infusion related reaction	101.33	9.80	135	108210	381027	110099927
Aplastic anaemia	99.54	9.80	121	108224	24187	110456767
Systemic lupus erythematosus	98.34	9.80	64	108281	254274	110226680
Dysplastic naevus	96.76	9.80	35	108310	813	110480141
Therapeutic product effect decreased	96.49	9.80	60	108285	244256	110236698
BRASH syndrome	95.19	9.80	54	108291	3669	110477285
Irritable bowel syndrome	93.23	9.80	23	108322	164192	110316762
Acute kidney injury	92.43	9.80	990	107355	634440	109846514
Blood pressure inadequately controlled	91.82	9.80	69	108276	7564	110473390
Lower respiratory tract infection	91.53	9.80	63	108282	243043	110237911
Discomfort	90.08	9.80	49	108296	214658	110266296
Blood urea increased	87.56	9.80	177	108168	54780	110426174
Blood pressure decreased	86.66	9.80	279	108066	114812	110366142
Pulmonary oedema	85.04	9.80	254	108091	100405	110380549
Cardiac failure	83.63	9.80	385	107960	187241	110293713
Wheezing	82.49	9.80	77	108268	255153	110225801
Oedema peripheral	81.87	9.80	577	107768	328083	110152871
Hepatic enzyme increased	80.93	9.80	118	108227	320774	110160180
Hypersensitivity	80.68	9.80	172	108173	403826	110077128
Solar lentigo	80.08	9.80	36	108309	1488	110479466
Hepatic function abnormal	79.90	9.80	230	108115	89065	110391889
Myocardial infarction	78.24	9.80	384	107961	191699	110289255
Rheumatic fever	76.06	9.80	14	108331	122565	110358389
Foetal growth restriction	74.66	9.80	43	108302	3007	110477947
Sleep disorder	72.77	9.80	53	108292	198591	110282363
Drug abuse	72.24	9.80	42	108303	177369	110303585
Cardiac arrest	70.84	9.80	380	107965	196373	110284581
Caesarean section	68.68	9.80	76	108269	13741	110467213
Drug intolerance	64.92	9.80	194	108151	406318	110074636
Chronic kidney disease	64.89	9.80	193	108152	76098	110404856
Neutropenia	64.08	9.80	173	108172	374447	110106507
Blood pressure systolic increased	62.29	9.80	201	108144	82790	110398164
Liver injury	62.11	9.80	35	108310	150378	110330576
Renal failure	61.27	9.80	406	107939	226168	110254786
Type 2 diabetes mellitus	60.22	9.80	51	108294	177181	110303773
Intentional product use issue	58.80	9.80	95	108250	247811	110233143
Acute myocardial infarction	58.50	9.80	198	108147	83579	110397375
Angina unstable	58.07	9.80	76	108269	16356	110464598
Primary hyperaldosteronism	57.59	9.80	18	108327	262	110480692
Anuria	57.44	9.80	93	108252	24248	110456706
Hypertensive crisis	57.35	9.80	93	108252	24279	110456675
Cerebrovascular accident	56.58	9.80	337	108008	180947	110300007
Kidney transplant rejection	56.27	9.80	64	108281	11923	110469031
Sinusitis	56.18	9.80	130	108215	296558	110184396
Abdominal discomfort	55.92	9.80	198	108147	393660	110087294
Urticaria	54.70	9.80	147	108198	318710	110162244
Mobility decreased	53.53	9.80	94	108251	237328	110243626
Treatment failure	52.88	9.80	121	108224	277113	110203841
Bursitis	52.54	9.80	31	108314	129887	110351067
Metabolic acidosis	52.32	9.80	215	108130	99529	110381425
Grip strength decreased	52.30	9.80	8	108337	80166	110400788
Ill-defined disorder	51.04	9.80	47	108298	156806	110324148
General physical health deterioration	50.76	9.80	229	108116	425066	110055888
Tubulointerstitial nephritis	50.68	9.80	142	108203	54142	110426812
Facet joint syndrome	50.41	9.80	16	108329	96812	110384142
Hyperuricaemia	49.48	9.80	66	108279	14465	110466489
Blister	49.48	9.80	92	108253	227284	110253670
Adverse drug reaction	48.97	9.80	21	108324	105538	110375416
Wound infection	48.37	9.80	17	108328	96448	110384506
Scleroderma	48.36	9.80	44	108301	6297	110474657
C-reactive protein abnormal	48.28	9.80	34	108311	129661	110351293
Oligohydramnios	47.81	9.80	36	108309	3958	110476996
Swelling	47.50	9.80	180	108165	350861	110130093
Lacunar infarction	46.73	9.80	43	108302	6243	110474711
Haemoglobin decreased	46.61	9.80	409	107936	248318	110232636
Pulmonary hypertension	46.30	9.80	139	108206	55081	110425873
Interstitial lung disease	46.05	9.80	263	108082	139071	110341883
Intestinal angioedema	45.49	9.80	22	108323	1075	110479879
Paradoxical drug reaction	45.38	9.80	52	108293	9765	110471189
Protein urine present	45.14	9.80	56	108289	11428	110469526
Dialysis	44.99	9.80	74	108271	19545	110461409
Lip dry	44.72	9.80	21	108324	100062	110380892
Sinobronchitis	44.39	9.80	17	108328	465	110480489
Blood aldosterone increased	44.22	9.80	14	108331	213	110480741
Inflammation	44.01	9.80	76	108269	193162	110287792
Polyhydramnios	44.00	9.80	26	108319	1907	110479047
Platelet count decreased	43.73	9.80	380	107965	230063	110250891
Therapeutic product effect incomplete	43.22	9.80	97	108248	223708	110257246
Night sweats	42.59	9.80	41	108304	133942	110347012
Bladder prolapse	42.58	9.80	23	108322	1419	110479535
Malignant hypertension	42.35	9.80	24	108321	1627	110479327
Off label use	42.18	9.80	1134	107211	1499051	108981903
Telangiectasia	42.08	9.80	25	108320	1852	110479102
Angina pectoris	41.54	9.80	145	108200	62150	110418804
Prescribed overdose	41.31	9.80	17	108328	87564	110393390
Aortic dissection	41.13	9.80	36	108309	4897	110476057
Stomatitis	40.97	9.80	132	108213	270110	110210844
Altered state of consciousness	40.94	9.80	137	108208	57489	110423465
Actinic keratosis	40.91	9.80	42	108303	6971	110473983
Blood pressure systolic abnormal	40.73	9.80	81	108264	24769	110456185
HELLP syndrome	40.71	9.80	19	108326	857	110480097
Infection	40.29	9.80	200	108145	362000	110118954
Scleroderma renal crisis	39.76	9.80	19	108326	904	110480050
Autoimmune disorder	39.51	9.80	8	108337	65475	110415479
Renal artery stenosis	38.97	9.80	31	108314	3695	110477259
Psoriasis	38.79	9.80	48	108297	139945	110341009
Atrioventricular block first degree	38.65	9.80	58	108287	14167	110466787
Dry mouth	38.33	9.80	87	108258	199861	110281093
Phaeochromocytoma	38.26	9.80	18	108327	827	110480127
Heart rate decreased	37.73	9.80	171	108174	82585	110398369
Atrioventricular block complete	37.27	9.80	69	108276	20013	110460941
Diabetic hyperosmolar coma	37.14	9.80	18	108327	884	110480070
Transfusion	37.01	9.80	79	108266	25393	110455561
Wrist deformity	36.53	9.80	28	108317	3161	110477793
Coronary artery disease	36.39	9.80	153	108192	71537	110409417
Diabetic nephropathy	36.29	9.80	29	108316	3479	110477475
Blood pressure fluctuation	35.91	9.80	157	108188	74667	110406287
Pemphigoid	35.68	9.80	67	108278	19640	110461314
Atrioventricular block	35.18	9.80	61	108284	16816	110464138
Knee arthroplasty	35.14	9.80	10	108335	64938	110416016
Musculoskeletal stiffness	34.98	9.80	148	108197	279674	110201280
Lower limb fracture	34.93	9.80	15	108330	75333	110405621
Acute pulmonary oedema	34.86	9.80	61	108284	16935	110464019
Azotaemia	34.64	9.80	46	108299	10039	110470915
Renal disorder	34.59	9.80	117	108228	49362	110431592
Gait inability	34.50	9.80	50	108295	136326	110344628
Rash	34.25	9.80	582	107763	820382	109660572
Weight increased	33.97	9.80	256	108089	419388	110061566
Eclampsia	33.83	9.80	13	108332	359	110480595
Hypercholesterolaemia	33.56	9.80	24	108321	90813	110390141
Sciatica	33.38	9.80	25	108320	92374	110388580
Hip arthroplasty	33.30	9.80	7	108338	55806	110425148
Dehydration	33.15	9.80	419	107926	279092	110201862
Nail disorder	33.10	9.80	8	108337	57927	110423027
Product use issue	33.02	9.80	175	108170	311520	110169434
Hypervolaemia	32.87	9.80	115	108230	49345	110431609
Dyspnoea exertional	32.81	9.80	194	108151	103866	110377088
Rectal prolapse	32.69	9.80	24	108321	2539	110478415
Nasopharyngitis	32.67	9.80	239	108106	394122	110086832
Bezoar	32.63	9.80	29	108316	4025	110476929
Pain	32.49	9.80	701	107644	954254	109526700
Injury	32.48	9.80	79	108266	177186	110303768
Myocardial ischaemia	32.33	9.80	77	108268	26607	110454347
Nephrotic syndrome	31.49	9.80	52	108293	13779	110467175
Phospholipidosis	31.48	9.80	12	108333	324	110480630
Arthralgia	31.45	9.80	556	107789	779076	109701878
Product residue present	31.34	9.80	28	108317	3913	110477041
Contraindicated product administered	31.22	9.80	131	108214	248136	110232818
Injection site reaction	31.03	9.80	25	108320	89045	110391909
Incorrect route of product administration	30.92	9.80	12	108333	64049	110416905
Peripheral vascular disorder	30.82	9.80	40	108305	8536	110472418
Blood pressure diastolic abnormal	30.75	9.80	74	108271	25741	110455213
Product use in unapproved indication	30.74	9.80	285	108060	447092	110033862
Liver function test increased	30.66	9.80	25	108320	88523	110392431
Prinzmetal angina	30.65	9.80	22	108323	2247	110478707
Incision site pain	30.49	9.80	25	108320	3110	110477844
Premature separation of placenta	30.19	9.80	19	108326	1561	110479393
Thrombotic cerebral infarction	30.17	9.80	15	108330	779	110480175
Peripheral venous disease	30.07	9.80	23	108322	84094	110396860
Memory impairment	29.98	9.80	96	108249	196848	110284106
Hypertension	29.96	9.80	682	107663	509402	109971552
Nephrogenic anaemia	29.62	9.80	29	108316	4548	110476406
Renal hypoplasia	29.34	9.80	6	108339	11	110480943
Renin decreased	29.25	9.80	9	108336	124	110480830
Preterm premature rupture of membranes	28.40	9.80	18	108327	1497	110479457
Paternal exposure during pregnancy	28.28	9.80	10	108335	217	110480737
Drug ineffective	28.23	9.80	1211	107134	1519329	108961625
Premature baby	28.19	9.80	29	108316	4826	110476128
Pain in jaw	28.17	9.80	112	108233	51065	110429889
Back injury	28.17	9.80	6	108339	47393	110433561
Left ventricular hypertrophy	27.77	9.80	48	108297	13196	110467758
Hypergammaglobulinaemia	27.51	9.80	15	108330	943	110480011
Aplasia pure red cell	27.38	9.80	40	108305	9538	110471416
Bone erosion	27.29	9.80	6	108339	46365	110434589
Glomerular filtration rate decreased	27.27	9.80	76	108269	28880	110452074
Foot deformity	27.10	9.80	7	108338	48473	110432481
Hepatic cytolysis	27.09	9.80	10	108335	55043	110425911
Hypertensive emergency	27.03	9.80	24	108321	3327	110477627
Intestinal pseudo-obstruction	27.00	9.80	24	108321	3332	110477622
Uraemic encephalopathy	26.95	9.80	14	108331	798	110480156
Blood cholesterol increased	26.80	9.80	92	108253	184693	110296261
Hyperaldosteronism	26.75	9.80	13	108332	642	110480312
Oesophageal obstruction	26.43	9.80	16	108329	1227	110479727
Pulse pressure increased	26.42	9.80	9	108336	174	110480780
Systemic scleroderma	26.37	9.80	19	108326	1953	110479001
Superimposed pre-eclampsia	26.15	9.80	6	108339	23	110480931
Rheumatoid arthritis	26.06	9.80	179	108166	299434	110181520
Blood lactate dehydrogenase increased	26.01	9.80	99	108246	44235	110436719
Maternal condition affecting foetus	26	9.80	9	108336	183	110480771
Fatigue	25.87	9.80	953	107392	1215005	109265949
Peripartum cardiomyopathy	25.82	9.80	9	108336	187	110480767
Hypoglycaemia	25.53	9.80	198	108147	115906	110365048
Tetany	25.53	9.80	24	108321	3580	110477374
Product quality issue	25.33	9.80	23	108322	77276	110403678
Drug dispensed to wrong patient	25.10	9.80	13	108332	736	110480218
Cerebral haemorrhage	25.09	9.80	128	108217	64840	110416114
Ventricular extrasystoles	24.95	9.80	63	108282	22578	110458376
Hypermagnesaemia	24.87	9.80	17	108328	1606	110479348
Periodontitis	24.78	9.80	28	108317	5180	110475774
Drug dependence	24.76	9.80	9	108336	50011	110430943
Product complaint	24.67	9.80	47	108298	13925	110467029
Squamous cell carcinoma of skin	24.58	9.80	53	108292	17150	110463804
Endometritis	24.56	9.80	14	108331	960	110479994
Pulmonary arterial hypertension	24.54	9.80	79	108266	32489	110448465
Hypokalaemia	24.46	9.80	280	108065	182168	110298786
Febrile neutropenia	24.33	9.80	196	108149	316571	110164383
Hypertensive encephalopathy	24.24	9.80	15	108330	1196	110479758
Platelet transfusion	24.19	9.80	21	108324	2825	110478129
Abdominal pain upper	24.14	9.80	222	108123	348889	110132065
CD30 expression	24.10	9.80	7	108338	78	110480876
Asthma	24.08	9.80	145	108200	250146	110230808
Ear infection	23.94	9.80	16	108329	62716	110418238
Oxygen saturation decreased	23.86	9.80	247	108098	156735	110324219
Pleural effusion	23.50	9.80	272	108073	177437	110303517
Dyspnoea	23.39	9.80	1316	107029	1105556	109375398
Finger amputation	23.23	9.80	13	108332	860	110480094
Medication overuse headache	23.08	9.80	16	108329	1547	110479407
Brain stem infarction	22.84	9.80	18	108327	2116	110478838
Blood glucose increased	22.82	9.80	214	108131	132282	110348672
Putamen haemorrhage	22.81	9.80	11	108334	534	110480420
Mental status changes	22.77	9.80	140	108205	75982	110404972
Hypocalcaemia	22.66	9.80	125	108220	65241	110415713
Urine output decreased	22.63	9.80	56	108289	19820	110461134
Red blood cell sedimentation rate increased	22.59	9.80	26	108319	78276	110402678
Lactic acidosis	22.51	9.80	162	108183	92649	110388305
Haemodialysis	22.42	9.80	52	108293	17667	110463287
Injection site erythema	22.40	9.80	36	108309	94140	110386814
Stillbirth	22.14	9.80	24	108321	4240	110476714
Gestational hypertension	22.12	9.80	18	108327	2216	110478738
Nephrogenic systemic fibrosis	21.97	9.80	27	108318	5456	110475498
Confusional state	21.94	9.80	325	108020	468355	110012599
Removal of internal fixation	21.82	9.80	5	108340	19	110480935
Generalised oedema	21.81	9.80	73	108272	30631	110450323
Sleep disorder due to a general medical condition	21.69	9.80	12	108333	52100	110428854
Blood albumin decreased	21.68	9.80	68	108277	27584	110453370
Exostosis	21.54	9.80	9	108336	45947	110435007
Contusion	21.51	9.80	137	108208	233224	110247730
Arrhythmia	21.47	9.80	129	108216	69446	110411508
Gastroenteritis	21.43	9.80	85	108260	38715	110442239
Umbilical cord vascular disorder	21.42	9.80	5	108340	21	110480933
Cardiac failure chronic	21.42	9.80	44	108301	13767	110467187
Immunosuppressant drug level increased	21.40	9.80	40	108305	11684	110469270
Allergic sinusitis	21.20	9.80	16	108329	1765	110479189
Wrong technique in product usage process	21.14	9.80	33	108312	87315	110393639
Endoscopy upper gastrointestinal tract abnormal	21.07	9.80	6	108339	62	110480892
Tricuspid valve incompetence	20.87	9.80	61	108284	23812	110457142
Gastrointestinal disorder	20.81	9.80	145	108200	241807	110239147
Low birth weight baby	20.78	9.80	12	108333	843	110480111
Suspected suicide	20.78	9.80	46	108299	15153	110465801
Osteoarthritis	20.77	9.80	100	108245	182523	110298431
Vomiting	20.63	9.80	708	107637	909967	109570987
Cardiac failure acute	20.55	9.80	61	108284	24017	110456937
HIV associated nephropathy	20.46	9.80	9	108336	353	110480601
Laryngitis	20.38	9.80	8	108337	42403	110438551
Adverse event	20.32	9.80	48	108297	108761	110372193
Hypoperfusion	20.30	9.80	20	108325	3161	110477793
Frequent bowel movements	20.28	9.80	24	108321	71366	110409588
Fluid retention	20.27	9.80	160	108185	94147	110386807
Oesophageal haemorrhage	20.26	9.80	16	108329	1887	110479067
Hepatic rupture	20.15	9.80	7	108338	144	110480810
Blood potassium increased	20.13	9.80	75	108270	33174	110447780
Photosensitivity reaction	20.13	9.80	63	108282	25526	110455428
Blood pressure diastolic decreased	20.13	9.80	79	108266	35806	110445148
Renal-limited thrombotic microangiopathy	19.78	9.80	10	108335	538	110480416
White blood cell count increased	19.57	9.80	162	108183	96680	110384274
Keratoacanthoma	19.47	9.80	14	108331	1434	110479520
Shunt occlusion	19.35	9.80	15	108330	1722	110479232
Foetal death	19.12	9.80	46	108299	15999	110464955
Anti-neutrophil cytoplasmic antibody positive vasculitis	19.06	9.80	25	108320	5392	110475562
Palpitations	19.00	9.80	239	108106	158973	110321981
Migraine	18.94	9.80	95	108250	171557	110309397
Diabetes mellitus	18.90	9.80	164	108181	99217	110381737
Epilepsy	18.88	9.80	44	108301	100165	110380789
Rubber sensitivity	18.87	9.80	17	108328	2401	110478553
Skin hypertrophy	18.86	9.80	24	108321	5023	110475931
Road traffic accident	18.79	9.80	49	108296	107349	110373605
Loss of consciousness	18.68	9.80	283	108062	196023	110284931
Respiratory tract inflammation	18.58	9.80	12	108333	1031	110479923
Electrocardiogram PR prolongation	18.56	9.80	15	108330	1828	110479126
Lung disorder	18.55	9.80	102	108243	179945	110301009
Ear pain	18.46	9.80	15	108330	53211	110427743
Sclerodactylia	18.37	9.80	7	108338	189	110480765
Loss of personal independence in daily activities	18.34	9.80	80	108265	149940	110331014
Injection site inflammation	18.33	9.80	23	108322	4748	110476206
Barotrauma	18.30	9.80	7	108338	191	110480763
Hyperplasia adrenal	18.28	9.80	5	108340	44	110480910
Thermal burn	18.14	9.80	30	108315	7958	110472996
Intentional self-injury	18.08	9.80	7	108338	37422	110443532
Finger deformity	18.08	9.80	5	108340	33087	110447867
Peritonitis bacterial	18.07	9.80	35	108310	10498	110470456
Nodular regenerative hyperplasia	17.98	9.80	14	108331	1617	110479337
Blood creatine phosphokinase increased	17.98	9.80	128	108217	72949	110408005
Intestinal ischaemia	17.81	9.80	45	108300	16134	110464820
Low density lipoprotein increased	17.76	9.80	35	108310	10631	110470323
Arteriosclerosis	17.69	9.80	59	108286	24708	110456246
Cognitive disorder	17.65	9.80	37	108308	87474	110393480
Peritoneal dialysis	17.60	9.80	11	108334	893	110480061
Pericardial effusion	17.60	9.80	106	108239	57111	110423843
Renal injury	17.51	9.80	49	108296	18664	110462290
Taste disorder	17.51	9.80	23	108322	65364	110415590
Obesity	17.42	9.80	55	108290	113296	110367658
Palmar-plantar erythrodysaesthesia syndrome	17.39	9.80	83	108262	40942	110440012
Renal atrophy	17.35	9.80	16	108329	2330	110478624
Thrombocytopenia	17.35	9.80	239	108106	348646	110132308
Hydronephrosis	17.30	9.80	52	108293	20613	110460341
Vascular resistance systemic increased	17.30	9.80	4	108341	16	110480938
Premature rupture of membranes	17.25	9.80	22	108323	4615	110476339
Adverse reaction	17.07	9.80	4	108341	29590	110451364
Drug level increased	17.04	9.80	92	108253	47627	110433327
Gastric cancer	16.99	9.80	35	108310	10973	110469981
Muscle spasticity	16.89	9.80	7	108338	35908	110445046
Diverticulum intestinal haemorrhagic	16.78	9.80	22	108323	4741	110476213
Ventricular hypertrophy	16.73	9.80	27	108318	7018	110473936
Rhabdomyolysis	16.69	9.80	186	108159	120215	110360739
Haemodilution	16.68	9.80	6	108339	137	110480817
Oliguria	16.63	9.80	48	108297	18609	110462345
Accidental exposure to product by child	16.60	9.80	18	108327	3180	110477774
Ileus paralytic	16.59	9.80	36	108309	11701	110469253
High density lipoprotein decreased	16.47	9.80	24	108321	5709	110475245
Atrioventricular block second degree	16.31	9.80	29	108316	8152	110472802
Peritoneal dialysis complication	16.23	9.80	16	108329	2530	110478424
Cardiomegaly	16.23	9.80	64	108281	29066	110451888
Sedation	16.23	9.80	27	108318	69656	110411298
Crepitations	16.20	9.80	34	108311	10801	110470153
Haemoperitoneum	16.13	9.80	23	108322	5365	110475589
Peripheral arterial occlusive disease	16.12	9.80	31	108314	9249	110471705
Peritonitis	16.09	9.80	69	108276	32538	110448416
Pulmonary fibrosis	16.04	9.80	49	108296	101993	110378961
Oesophageal dilatation	15.91	9.80	9	108336	608	110480346
Peripheral coldness	15.85	9.80	47	108298	18493	110462461
Foetal hypokinesia	15.82	9.80	8	108337	431	110480523
Hypoproteinaemia	15.81	9.80	24	108321	5921	110475033
Frostbite	15.81	9.80	7	108338	279	110480675
Thalamus haemorrhage	15.71	9.80	14	108331	1950	110479004
Lymphocyte count decreased	15.71	9.80	103	108242	57140	110423814
Blood corticotrophin decreased	15.69	9.80	10	108335	840	110480114
Hyperventilation	15.68	9.80	30	108315	8917	110472037
Drug eruption	15.62	9.80	98	108247	53561	110427393
Nodal rhythm	15.60	9.80	18	108327	3405	110477549
Large intestine polyp	15.56	9.80	41	108304	15076	110465878
Condition aggravated	15.55	9.80	576	107769	734260	109746694
Joint dislocation	15.54	9.80	7	108338	34183	110446771
Skin tightness	15.41	9.80	23	108322	5590	110475364
Brain natriuretic peptide increased	15.41	9.80	34	108311	11175	110469779
Atrial fibrillation	15.37	9.80	313	108032	229329	110251625
Colitis ulcerative	15.36	9.80	33	108312	77330	110403624
Drug tolerance decreased	15.35	9.80	4	108341	27536	110453418
Neutrophil count increased	15.34	9.80	71	108274	34581	110446373
Red blood cells urine positive	15.33	9.80	22	108323	5163	110475791
Small for dates baby	15.32	9.80	9	108336	653	110480301
Shunt stenosis	15.28	9.80	12	108333	1404	110479550
Chronic sinusitis	15.27	9.80	3	108342	25081	110455873
Multiple sclerosis relapse	15.25	9.80	16	108329	50224	110430730
Decreased appetite	15.22	9.80	590	107755	475256	110005698
Chest discomfort	15.16	9.80	247	108098	173601	110307353
Amniotic cavity infection	15.10	9.80	10	108335	897	110480057
Pneumonia	15.06	9.80	1024	107321	875690	109605264
Diabetic retinopathy	15.01	9.80	18	108327	3546	110477408
Chronic allograft nephropathy	14.76	9.80	14	108331	2112	110478842
Immunodeficiency	14.69	9.80	10	108335	38828	110442126
Hypoaesthesia	14.65	9.80	218	108127	314005	110166949
Human chorionic gonadotropin positive	14.64	9.80	4	108341	35	110480919
Injection site pain	14.63	9.80	108	108237	177814	110303140
Aspartate aminotransferase increased	14.61	9.80	229	108116	159707	110321247
Intentional overdose	14.59	9.80	196	108149	132305	110348649
Vitamin D decreased	14.53	9.80	35	108310	12180	110468774
Anti-erythropoietin antibody positive	14.52	9.80	9	108336	720	110480234
Sinus arrhythmia	14.51	9.80	14	108331	2156	110478798
Myocardial depression	14.49	9.80	9	108336	723	110480231
Toxicity to various agents	14.48	9.80	592	107753	479963	110000991
Procedural hypertension	14.48	9.80	7	108338	342	110480612
Onychomycosis	14.47	9.80	10	108335	38521	110442433
Complications of transplanted kidney	14.35	9.80	26	108319	7416	110473538
Hypergastrinaemia	14.34	9.80	7	108338	349	110480605
Poisoning deliberate	14.34	9.80	4	108341	26327	110454627
Oedema	14.31	9.80	287	108058	209689	110271265
Upper gastrointestinal haemorrhage	14.27	9.80	91	108254	50005	110430949
Haemorrhage subcutaneous	14.22	9.80	22	108323	5517	110475437
Arteriospasm coronary	14.12	9.80	29	108316	9071	110471883
Urinary tract infection	14.09	9.80	419	107926	325863	110155091
Cholangitis acute	14.05	9.80	13	108332	1900	110479054
Anaemia of pregnancy	14.03	9.80	5	108340	111	110480843
Chorioretinopathy	13.85	9.80	14	108331	2281	110478673
Intentional product misuse	13.85	9.80	75	108270	132829	110348125
Depression	13.83	9.80	223	108122	317112	110163842
Pulmonary embolism	13.71	9.80	139	108206	214335	110266619
Ileus	13.63	9.80	63	108282	30666	110450288
Hypoaesthesia teeth	13.58	9.80	4	108341	47	110480907
Vertebral artery stenosis	13.58	9.80	6	108339	238	110480716
Heliotrope rash	13.58	9.80	6	108339	238	110480716
Cerebral hyperperfusion syndrome	13.52	9.80	5	108340	124	110480830
Sinus bradycardia	13.49	9.80	61	108284	29422	110451532
End stage renal disease	13.47	9.80	49	108296	21424	110459530
Hyperglycaemia	13.46	9.80	135	108210	84955	110395999
Hepatic cirrhosis	13.30	9.80	29	108316	67597	110413357
Hyphaema	13.30	9.80	10	108335	1097	110479857
Dyslalia	13.29	9.80	11	108334	1386	110479568
Bradycardia foetal	13.26	9.80	5	108340	131	110480823
Compartment syndrome	13.16	9.80	22	108323	5888	110475066
Mucosal erosion	13.12	9.80	15	108330	2809	110478145
Renal transplant	13.06	9.80	16	108329	3222	110477732
Postrenal failure	13.01	9.80	9	108336	867	110480087
Peripheral swelling	12.99	9.80	299	108046	403735	110077219
Post transplant distal limb syndrome	12.94	9.80	9	108336	875	110480079
Communication disorder	12.92	9.80	20	108325	5019	110475935
Focal segmental glomerulosclerosis	12.86	9.80	18	108327	4127	110476827
Coronary artery stenosis	12.85	9.80	36	108309	13722	110467232
Cerebellar infarction	12.72	9.80	18	108327	4169	110476785
Underdose	12.71	9.80	27	108318	63527	110417427
Threatened labour	12.68	9.80	8	108337	660	110480294
Cerebrovascular insufficiency	12.66	9.80	5	108340	149	110480805
Hyperinsulinaemia	12.65	9.80	6	108339	281	110480673
Joint range of motion decreased	12.56	9.80	69	108276	121763	110359191
Gastrointestinal necrosis	12.55	9.80	23	108322	6617	110474337
Post procedural urine leak	12.47	9.80	5	108340	155	110480799
Tongue oedema	12.45	9.80	26	108319	8230	110472724
Peripheral ischaemia	12.43	9.80	31	108314	11027	110469927
Carotid artery disease	12.40	9.80	13	108332	2210	110478744
Intracardiac mass	12.37	9.80	6	108339	295	110480659
Atypical haemolytic uraemic syndrome	12.36	9.80	11	108334	1529	110479425
Cytokine release syndrome	12.35	9.80	32	108313	70274	110410680
Paranasal sinus inflammation	12.34	9.80	6	108339	297	110480657
Enteritis infectious	12.26	9.80	17	108328	3865	110477089
Dermatophytosis of nail	12.19	9.80	6	108339	305	110480649
Use of accessory respiratory muscles	12.17	9.80	8	108337	708	110480246
Hyperthermia	12.03	9.80	3	108342	21269	110459685
Histiocytic necrotising lymphadenitis	12.01	9.80	4	108341	72	110480882
Neuropathy peripheral	11.95	9.80	115	108230	179162	110301792
Depressed level of consciousness	11.92	9.80	165	108180	112113	110368841
Product substitution error	11.91	9.80	4	108341	74	110480880
Amnesia	11.82	9.80	58	108287	105350	110375604
Cough	11.76	9.80	559	107786	461082	110019872
Renal cyst haemorrhage	11.73	9.80	8	108337	753	110480201
Concomitant disease aggravated	11.71	9.80	39	108306	16325	110464629
Pituitary tumour recurrent	11.69	9.80	5	108340	183	110480771
Upper respiratory tract infection	11.64	9.80	78	108267	131250	110349704
Cholecystitis acute	11.63	9.80	38	108307	15744	110465210
Syncope	11.61	9.80	270	108075	202266	110278688
Peripheral embolism	11.53	9.80	12	108333	2023	110478931
Aortic valve incompetence	11.53	9.80	30	108315	10951	110470003
Cervical incompetence	11.52	9.80	7	108338	540	110480414
Neutropenic sepsis	11.52	9.80	8	108337	30738	110450216
Transferrin decreased	11.51	9.80	7	108338	541	110480413
Pneumonia aspiration	11.49	9.80	126	108219	81107	110399847
Marasmus	11.48	9.80	11	108334	1680	110479274
Restrictive cardiomyopathy	11.47	9.80	9	108336	1052	110479902
Sprue-like enteropathy	11.45	9.80	11	108334	1685	110479269
Hepatocellular carcinoma	11.42	9.80	28	108317	9852	110471102
Anaemia	11.41	9.80	650	107695	546436	109934518
Laboratory test interference	11.34	9.80	10	108335	1373	110479581
Arteriovenous fistula operation	11.29	9.80	6	108339	358	110480596
Apnoeic attack	11.26	9.80	8	108337	804	110480150
Hyperparathyroidism secondary	11.24	9.80	15	108330	3289	110477665
Gastric ileus	11.22	9.80	3	108342	24	110480930
Papillary renal cell carcinoma	11.22	9.80	6	108339	363	110480591
Electrocardiogram QRS complex shortened	11.19	9.80	8	108337	812	110480142
Myelosuppression	11.11	9.80	51	108294	94289	110386665
Mitral valve incompetence	11.06	9.80	63	108282	33266	110447688
Atheroembolism	11.04	9.80	6	108339	375	110480579
Urticaria pigmentosa	11.01	9.80	3	108342	26	110480928
Glomerulonephritis membranoproliferative	10.93	9.80	8	108337	842	110480112
Lip haemorrhage	10.92	9.80	10	108335	1442	110479512
Stevens-Johnson syndrome	10.88	9.80	81	108264	46820	110434134
Abdominal symptom	10.87	9.80	8	108337	850	110480104
Thyroid operation	10.85	9.80	5	108340	219	110480735
Atrioventricular dissociation	10.85	9.80	6	108339	388	110480566
Sedation complication	10.85	9.80	3	108342	19852	110461102
Blood pressure systolic	10.82	9.80	4	108341	99	110480855
Haemophagocytic lymphohistiocytosis	10.81	9.80	9	108336	31550	110449404
Paternal exposure before pregnancy	10.81	9.80	3	108342	28	110480926
Hypertensive urgency	10.78	9.80	9	108336	1148	110479806
Joint stiffness	10.78	9.80	32	108313	67211	110413743
Thymic cyst	10.75	9.80	4	108341	101	110480853
Pancreatic neuroendocrine tumour metastatic	10.74	9.80	5	108340	224	110480730
Hypothyroidism	10.74	9.80	114	108231	72785	110408169
Immobilisation syndrome	10.72	9.80	8	108337	868	110480086
Colitis ischaemic	10.71	9.80	40	108305	17710	110463244
Acute coronary syndrome	10.71	9.80	48	108297	23064	110457890
Adrenal adenoma	10.69	9.80	10	108335	1482	110479472
Skin induration	10.65	9.80	17	108328	4378	110476576
Cutaneous lupus erythematosus	10.61	9.80	15	108330	3473	110477481
Inappropriate antidiuretic hormone secretion	10.59	9.80	63	108282	33788	110447166
Immune-mediated myocarditis	10.57	9.80	15	108330	3483	110477471
Hepatocellular injury	10.56	9.80	21	108324	50621	110430333
Extrapyramidal disorder	10.54	9.80	56	108289	28811	110452143
Alanine aminotransferase increased	10.54	9.80	245	108100	183528	110297426
Nephropathy toxic	10.51	9.80	54	108291	27424	110453530
Aspergillus infection	10.51	9.80	6	108339	25610	110455344
Ascites	10.51	9.80	138	108207	92670	110388284
Meningitis staphylococcal	10.50	9.80	5	108340	236	110480718
Bradyarrhythmia	10.50	9.80	18	108327	4916	110476038
Immune-mediated hepatic disorder	10.49	9.80	17	108328	4433	110476521
Pyuria	10.49	9.80	13	108332	2650	110478304
Withdrawal hypertension	10.45	9.80	6	108339	417	110480537
Skin squamous cell carcinoma recurrent	10.43	9.80	4	108341	110	110480844
Mixed connective tissue disease	10.42	9.80	6	108339	419	110480535
Glucose urine present	10.37	9.80	12	108333	2277	110478677
Pseudolymphoma	10.27	9.80	9	108336	1226	110479728
Tonsillar hypertrophy	10.22	9.80	11	108334	1927	110479027
Mallory-Weiss syndrome	10.22	9.80	14	108331	3147	110477807
Hypoxia	10.19	9.80	181	108164	129334	110351620
Cholestasis	10.13	9.80	31	108314	64487	110416467
Cell marker increased	10.12	9.80	7	108338	674	110480280
Walking aid user	10.11	9.80	6	108339	25069	110455885
Vascular resistance systemic decreased	10.03	9.80	5	108340	261	110480693
Tuberculin test positive	10.03	9.80	15	108330	3653	110477301
Mechanical ileus	10.01	9.80	9	108336	1268	110479686
Hypogonadism	9.97	9.80	11	108334	1983	110478971
Musculoskeletal pain	9.96	9.80	123	108222	182900	110298054
Induration	9.96	9.80	12	108333	2377	110478577
Respiratory arrest	9.95	9.80	94	108251	58205	110422749
Heart rate increased	9.93	9.80	197	108148	143637	110337317
Illness	9.93	9.80	44	108301	82127	110398827
Skin haemorrhage	9.93	9.80	6	108339	24821	110456133
Lymphopenia	9.89	9.80	15	108330	40155	110440799
Skin discolouration	9.88	9.80	82	108263	48964	110431990
Blood triglycerides increased	9.85	9.80	48	108297	23878	110457076
Feeling cold	9.84	9.80	62	108283	33925	110447029
Affect lability	9.84	9.80	3	108342	18634	110462320
Renal cyst infection	9.82	9.80	5	108340	273	110480681
Urinary retention	9.81	9.80	108	108237	69575	110411379

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C07FB03	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C08CA05	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C08CA55	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C08GA01	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics
FDA CS	M0006414	Dihydropyridines
FDA MoA	N0000000069	Calcium Channel Antagonists
FDA EPC	N0000175421	Dihydropyridine Calcium Channel Blocker
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D012102	Reproductive Control Agents
MeSH PA	D014665	Vasodilator Agents
MeSH PA	D015149	Tocolytic Agents
MeSH PA	D049990	Membrane Transport Modulators
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35620	vasodilator agent
CHEBI has role	CHEBI:35623	anticonvulsant
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:38215	calcium channel blocker
CHEBI has role	CHEBI:53784	antispasmodic drug
CHEBI has role	CHEBI:66993	tocolytic agent
CHEBI has role	CHEBI:76595	nephroprotective agent
CHEBI has role	CHEBI:77746	human metabolite

Related Drugs by ATC class:

C07FB Beta blocking agents and calcium channel blockers 6 drugs

amlodipine atenolol bisoprolol felodipine metoprolol nebivolol

C08CA Dihydropyridine derivatives 17 drugs

amlodipine barnidipine benidipine celecoxib cilnidipine clevidipine felodipine isradipine lacidipine lercanidipine levamlodipine manidipine show all 17 →

C08GA Calcium channel blockers and diuretics 1 drug

amlodipine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Prinzmetal angina	indication	87343002
Angina pectoris	indication	194828000
Premature labor	off-label use	6383007
Raynaud's phenomenon	off-label use	266261006
Cirrhosis of liver	contraindication	19943007	DOID:5082
Myocardial infarction	contraindication	22298006	DOID:5844
Stenosis of intestine	contraindication	23065003
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Chronic idiopathic constipation	contraindication	82934008
Left heart failure	contraindication	85232009
Cardiogenic shock	contraindication	89138009
Kidney disease	contraindication	90708001	DOID:557
Gastrointestinal obstruction	contraindication	126765001
Disease of liver	contraindication	235856003	DOID:409
Pyloric obstruction	contraindication	244815007
Peripheral edema	contraindication	271809000
Continent ileostomy - stoma	contraindication	311414006
Non-Q wave myocardial infarction	contraindication	314207007
Acute coronary syndrome	contraindication	394659003
Porphyria	contraindication	418470004
Severe Aortic Valve Stenosis	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.5	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Voltage-dependent L-type calcium channel subunit alpha-1D	Ion channel	Q01668	CAC1D_HUMAN	GATING INHIBITOR	IC50	7.70	IUPHAR	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel	Q13936	CAC1C_HUMAN	BLOCKER	Kd	9.40	CHEMBL	SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	4.30	WOMBAT-PK
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	5.26	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.50	PDSP
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.02	DRUG MATRIX
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN		Ki	5.35	DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.08	CHEMBL
Glutathione reductase, mitochondrial	Enzyme	P00390	GSHR_HUMAN		Ki	4.76	CHEMBL
Transthyretin	Secreted	P02766	TTHY_HUMAN		IC50	5.66	WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	4.30	CHEMBL
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN		IC50	5.48	CHEMBL
Bile salt export pump	Transporter	O95342	ABCBB_HUMAN		IC50	4.51	CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H	Ion channel	O95180	CAC1H_HUMAN		Ki	4.67	WOMBAT-PK
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	6.52	DRUG MATRIX
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN		IC50	6.37	CHEMBL
Potassium voltage-gated channel subfamily A member 1	Ion channel	Q09470	KCNA1_HUMAN		IC50	4.02	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S	Ion channel	Q13698	CAC1S_HUMAN	INHIBITOR	IC50	6.30	IUPHAR
Potassium voltage-gated channel subfamily A member 5	Ion channel	P22460	KCNA5_HUMAN		IC50	5.21	CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Enzyme	P27815	PDE4A_HUMAN		IC50	4.36	DRUG MATRIX
Glycine receptor subunit beta	Ion channel	P48167	GLRB_HUMAN	ANTAGONIST	IC50	5.90	IUPHAR
Potassium voltage-gated channel subfamily A member 2	Ion channel	P16389	KCNA2_HUMAN		Kd	4.70	WOMBAT-PK
Myosin light chain kinase, smooth muscle	Kinase	Q15746	MYLK_HUMAN		IC50	5.69	CHEMBL
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	4.73	DRUG MATRIX
C-C chemokine receptor type 2	GPCR	P41597	CCR2_HUMAN		Ki	6.07	DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1F	Ion channel	O60840	CAC1F_HUMAN	GATING INHIBITOR	IC50	6	IUPHAR
Glycine receptor subunit alpha-3	Ion channel	O75311	GLRA3_HUMAN	ANTAGONIST	IC50	4.50	IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	4.43	CHEMBL
Sodium/nucleoside cotransporter 1	Transporter	O00337	S28A1_HUMAN		Ki	5.09	DRUG MATRIX
Adenosine receptor A2a	GPCR	P29274	AA2AR_HUMAN		Ki	4.65	CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	4.82	DRUG MATRIX
Adenosine receptor A1	GPCR		AA1R_RAT		Ki	5.54	CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL		Ki	5.40	CHEMBL
Adenosine receptor A2a	GPCR		AA2AR_RAT		Ki	4.74	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RABIT		IC50	9	CHEMBL
Translocator protein	Membrane receptor		TSPO_RAT		IC50	9.30	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RAT		Ki	8.46	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D	Ion channel		CAC1D_RAT		Ki	8.92	CHEMBL
Cholinesterase	Enzyme		CHLE_HORSE		Ki	5.92	CHEMBL
Indoleamine 2,3-dioxygenase 2	Enzyme		I23O2_MOUSE		IC50	5.82	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_CAVPO		IC50	8.59	CHEMBL
Voltage-gated L-type calcium channel	Ion channel		CAC1C_RAT CAC1D_RAT CAC1S_RAT		Ki	8.33	CHEMBL
Bile salt export pump	Transporter		ABCBB_RAT		IC50	4.34	CHEMBL
Potassium voltage-gated channel subfamily A member 7	Ion channel		KCNA7_MOUSE	BLOCKER	IC50	4.90	IUPHAR
Potassium voltage-gated channel subfamily A member 1	Ion channel		KCNA1_MOUSE	BLOCKER	IC50	4	IUPHAR
Potassium voltage-gated channel subfamily A member 2	Ion channel		KCNA2_RAT	BLOCKER	Kd	4.70	IUPHAR
Potassium channel subfamily K member 2	Ion channel		Q8HY88_BOVIN		IC50	5.09	CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme		I23O1_MOUSE		IC50	4.34	CHEMBL

External reference:

ID	Source
4018390	VUID
N0000146717	NUI
D00437	KEGG_DRUG
4018390	VANDF
C0028066	UMLSCUI
CHEBI:7565	CHEBI
C5U	PDB_CHEM_ID
CHEMBL193	ChEMBL_ID
DB01115	DRUGBANK_ID
D009543	MESH_DESCRIPTOR_UI
4485	PUBCHEM_CID
2514	IUPHAR_LIGAND_ID
3222	INN_ID
I9ZF7L6G2L	UNII
7417	RXNORM
2302	MMSL
5175	MMSL
d00051	MMSL
000710	NDDF
017700	NDDF
387490003	SNOMEDCT_US
85272000	SNOMEDCT_US
I9ZF7L6G2L	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ProcardiaXL	HUMAN PRESCRIPTION DRUG LABEL	1	0069-2650	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	NDA	20 sections
ProcardiaXL	HUMAN PRESCRIPTION DRUG LABEL	1	0069-2660	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	NDA	20 sections
ProcardiaXL	HUMAN PRESCRIPTION DRUG LABEL	1	0069-2670	TABLET, FILM COATED, EXTENDED RELEASE	90 mg	ORAL	NDA	20 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8549	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7080	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7081	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7082	TABLET, FILM COATED, EXTENDED RELEASE	90 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7208	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	12 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7229	CAPSULE	10 mg	ORAL	ANDA	19 sections
NIFEDIPINE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-319	CAPSULE, LIQUID FILLED	10 mg	ORAL	ANDA	19 sections
NIFEDIPINE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-948	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	11 sections
nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	21695-807	TABLET, FILM COATED, EXTENDED RELEASE	90 mg	ORAL	ANDA	20 sections
nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	21695-908	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	20 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	21695-909	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	14 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	23155-194	CAPSULE	10 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	23155-195	CAPSULE	20 mg	ORAL	ANDA	19 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-009	TABLET, EXTENDED RELEASE	90 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-009	TABLET, EXTENDED RELEASE	90 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-010	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-010	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-011	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	24979-011	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	11 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	33261-840	TABLET, FILM COATED, EXTENDED RELEASE	90 mg	ORAL	ANDA	22 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	42254-095	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	22 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	43353-209	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	25 sections
AfeditabCR	HUMAN PRESCRIPTION DRUG LABEL	1	43353-782	TABLET, FILM COATED, EXTENDED RELEASE	60 mg	ORAL	ANDA	13 sections
AfeditabCR	HUMAN PRESCRIPTION DRUG LABEL	1	43353-792	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	13 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	43353-929	TABLET, FILM COATED, EXTENDED RELEASE	30 mg	ORAL	ANDA	22 sections
Nifedipine	HUMAN PRESCRIPTION DRUG LABEL	1	43386-440	CAPSULE	10 mg	ORAL	ANDA	19 sections
Nifedipine	Human Prescription Drug Label	1	46708-732	TABLET, EXTENDED RELEASE	30 mg	ORAL	ANDA	17 sections

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nifedipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: