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temocapril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 2586 | 111902-57-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
| BA (Bioavailability) | 52 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.444 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 4.539 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 20.045 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 16.444 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 5.320 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 9.260 | % | High | 1 |
| herg | hERG pIC50 | 4.395 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 49.888 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 50.234 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 4.290 | % | High | 1 |
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 | 23 | |||
| kinase-selectivity-class | AXL,BRAF,EPHB4,GRK2,MAP2K6 | 5 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 5.689 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.664 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 74.645 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 3.310 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 9.638 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 5.990 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.006 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 113.501 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 74.170 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 3.450 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 984.011 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1994 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09AA14 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
Related Drugs by ATC class:
C09AA ACE inhibitors, plain 15 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.12 | acidic |
| pKa2 | 5.71 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | DRUG LABEL | SCIENTIFIC LITERATURE | |||||
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.44 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D01119 | KEGG_DRUG |
| C0753183 | UMLSCUI |
| CHEBI:135771 | CHEBI |
| CHEMBL2110627 | ChEMBL_ID |
| CHEMBL2104499 | ChEMBL_ID |
| DB08836 | DRUGBANK_ID |
| C055603 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11736 | IUPHAR_LIGAND_ID |
| 6712 | INN_ID |
| 110221-44-8 | SECONDARY_CAS_RN |
| 18IZ008EU6 | UNII |
| 443874 | PUBCHEM_CID |
| 010988 | NDDF |
| 010989 | NDDF |
| C0646101 | UMLSCUI |
| CHEMBL300841 | ChEMBL_ID |
| 110221-53-9 | SECONDARY_CAS_RN |
| 443151 | PUBCHEM_CID |
| 11737 | IUPHAR_LIGAND_ID |
| 7673 | INN_ID |
| C069156 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2D6A12Q12R | UNII |
| CHEBI:9436 | CHEBI |
| 18IZ008EU6 | INXIGHT DRUGS |
| 2D6A12Q12R | INXIGHT DRUGS |
Pharmaceutical products:
None