celecoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 568 169590-42-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • celecoxib
  • celebrex
  • celecox
  • celocoxib
  • onsenal
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
  • Molecular weight: 381.37
  • Formula: C17H14F3N3O2S
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 77.98
  • ALOGS: -4.88
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 17.49 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability) 64 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.777 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.776 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 55.976 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 7.328 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.530 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 3.920 % High 1
herg hERG pIC50 4.801 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 18.836 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 13.868 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.810 % High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.361 High 1
mh-clint Mouse hepatocyte intrinsic clearance 22.491 High 1
mppb Mouse plasma protein binding (% unbound) 0.850 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.776 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 1.830 % High 1
rh-clint Rat hepatocyte intrinsic clearance 13.996 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 7.340 % High 1
rppb Rat plasma protein binding (% unbound) 1.040 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 3.141 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1998 FDA GD SEARLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1273.57 10.20 4697 393427 458912 89771411
Rheumatoid arthritis 645.36 10.20 3224 394900 359390 89870933
Fibromyalgia 595.95 10.20 2127 395997 204142 90026181
Toxicity to various agents 580.40 10.20 269 397855 287577 89942746
Psoriatic arthropathy 547.81 10.20 2219 395905 226116 90004207
Death 529.80 10.20 740 397384 455811 89774512
Musculoskeletal stiffness 529.04 10.20 2639 395485 293893 89936430
Neutropenia 429.34 10.20 226 397898 224678 90005645
C-reactive protein abnormal 391.07 10.20 1341 396783 126088 90104235
Mobility decreased 372.22 10.20 2122 396002 248612 89981711
Febrile neutropenia 368.69 10.20 118 398006 158231 90072092
Ankylosing spondylitis 368 10.20 366 397758 12767 90217556
Acute kidney injury 365.70 10.20 525 397599 319862 89910461
Anaemia 363.81 10.20 619 397505 352183 89878140
Facet joint syndrome 360.33 10.20 1100 397024 97289 90133034
Joint range of motion decreased 345.76 10.20 1344 396780 134299 90096024
Completed suicide 341.45 10.20 106 398018 144952 90085371
Osteoarthritis 327.08 10.20 1711 396413 194019 90036304
Type 2 diabetes mellitus 325.52 10.20 1756 396368 201488 90028835
Hypoaesthesia 318.16 10.20 2416 395708 311794 89918529
Breast cancer stage III 317.55 10.20 953 397171 83494 90146829
Inflammation 307.96 10.20 1575 396549 177017 90053306
Gait inability 305.76 10.20 1365 396759 145091 90085232
Arthralgia 304.34 10.20 4953 393171 773569 89456754
Lip dry 296.33 10.20 1047 397077 99908 90130415
Rheumatic fever 292.21 10.20 1390 396734 151731 90078592
C-reactive protein increased 290.98 10.20 1568 396556 179821 90050502
Bursitis 281.59 10.20 1236 396888 130418 90099905
Thrombocytopenia 279.99 10.20 302 397822 208423 90021900
Hypotension 278.37 10.20 637 397487 324760 89905563
Sciatica 276.02 10.20 1026 397098 100356 90129967
Drug abuse 275.51 10.20 23 398101 82324 90147999
Therapeutic product effect decreased 271.83 10.20 2118 396006 275453 89954870
Intentional overdose 269.93 10.20 44 398080 93790 90136533
Deep vein thrombosis postoperative 269.91 10.20 803 397321 70006 90160317
Hyponatraemia 249.17 10.20 138 397986 133400 90096923
Autoimmune disorder 248.94 10.20 823 397301 75921 90154402
Injury 247.47 10.20 1599 396525 195750 90034573
Musculoskeletal pain 243.95 10.20 1434 396690 169817 90060506
Lower limb fracture 243.77 10.20 875 397249 84138 90146185
Blood cholesterol increased 242.49 10.20 1655 396469 206357 90023966
Disease progression 235.08 10.20 205 397919 156410 90073913
Liver injury 234.45 10.20 1415 396709 169152 90061171
Liver disorder 224.19 10.20 1091 397033 120178 90110145
Impaired healing 222.59 10.20 1775 396349 232424 89997899
Foot deformity 221.23 10.20 670 397454 58981 90171342
Grip strength decreased 221.12 10.20 899 397225 91677 90138646
Dry mouth 219.03 10.20 1472 396652 182587 90047736
Constipation 216.97 10.20 578 397546 279817 89950506
Folliculitis 216.65 10.20 1589 396535 202764 90027559
Joint swelling 212.00 10.20 3244 394880 500056 89730267
Road traffic accident 211.10 10.20 985 397139 106641 90123682
Swollen joint count increased 209.55 10.20 1006 397118 110200 90120123
Arthropathy 204.73 10.20 2484 395640 363758 89866565
Blepharospasm 203.97 10.20 621 397503 54824 90175499
Wound infection 195.77 10.20 956 397168 105446 90124877
Loss of personal independence in daily activities 195.28 10.20 1142 396982 134963 90095360
Seizure 188.30 10.20 236 397888 152393 90077930
Duodenal ulcer perforation 187.75 10.20 1635 396489 219653 90010670
Sepsis 187.45 10.20 313 397811 179501 90050822
Dyspnoea 186.89 10.20 2736 395388 878219 89352104
Electrocardiogram QT prolonged 185.35 10.20 45 398079 72411 90157912
Drug tolerance 178.86 10.20 299 397825 17617 90212706
Drug intolerance 175.89 10.20 2852 395272 444739 89785584
Dehydration 174.93 10.20 370 397754 194077 90036246
Pain in extremity 170.47 10.20 2853 395271 447676 89782647
Obesity 170.40 10.20 914 397210 104593 90125730
Sleep disorder 167.89 10.20 1463 396661 196567 90033756
Hypercholesterolaemia 167.71 10.20 881 397243 100011 90130312
Synovitis 166.11 10.20 2194 395930 327558 89902765
Suicide attempt 165.42 10.20 62 398062 75337 90154986
Rheumatoid nodule 164.45 10.20 308 397816 19858 90210465
Neuropathy peripheral 163.58 10.20 217 397907 136753 90093570
Foetal exposure during pregnancy 162.14 10.20 6 398118 42969 90187354
Helicobacter infection 158.85 10.20 1609 396515 225241 90005082
Condition aggravated 158.32 10.20 3574 394550 591971 89638352
Pancytopenia 156.82 10.20 178 397946 120085 90110238
Product dose omission issue 156.16 10.20 704 397420 290983 89939340
Pulmonary fibrosis 155.47 10.20 904 397220 106599 90123724
Peripheral venous disease 152.92 10.20 752 397372 83169 90147154
Somnolence 152.03 10.20 444 397680 208640 90021683
Urticaria 149.76 10.20 2062 396062 310672 89919651
Live birth 149.27 10.20 716 397408 78391 90151932
Drug interaction 146.92 10.20 669 397455 275784 89954539
Prescribed overdose 146.45 10.20 829 397295 96796 90133527
Irritable bowel syndrome 145.53 10.20 1472 396652 205976 90024347
C-reactive protein 145.38 10.20 382 397742 30985 90199338
Device expulsion 143.70 10.20 9 398115 40877 90189446
Therapeutic product effect incomplete 142.39 10.20 1389 396735 192507 90037816
Syncope 140.97 10.20 228 397896 132435 90097888
Arthritis 139.67 10.20 1232 396892 166083 90064240
Myelosuppression 139.61 10.20 32 398092 53559 90176764
Contraindicated product administered 139.02 10.20 2075 396049 318064 89912259
Malignant neoplasm progression 135.22 10.20 162 397962 106708 90123615
Cardiac arrest 134.99 10.20 157 397967 104778 90125545
Hypoglycaemia 134.95 10.20 69 398055 69779 90160544
Respiratory failure 134.00 10.20 195 397929 118223 90112100
Lung disorder 133.14 10.20 1119 397005 148764 90081559
Red blood cell sedimentation rate increased 131.65 10.20 713 397411 81882 90148441
Rheumatoid factor positive 131.14 10.20 1240 396884 170410 90059913
Mucosal inflammation 127.06 10.20 47 398077 57578 90172745
Premature delivery 126.48 10.20 12 398112 38750 90191573
Neck pain 124.62 10.20 893 397231 113070 90117253
Hypertension 123.39 10.20 2752 395372 454780 89775543
Treatment failure 122.75 10.20 1946 396178 301982 89928341
Abortion spontaneous 121.03 10.20 43 398081 54013 90176310
Back injury 119.54 10.20 463 397661 46159 90184164
Tremor 117.44 10.20 317 397807 152856 90077467
Prescribed underdose 117.13 10.20 644 397480 74375 90155948
Platelet count decreased 117.09 10.20 268 397856 136701 90093622
Ill-defined disorder 116.53 10.20 1284 396840 183607 90046716
Night sweats 116.30 10.20 965 397159 127801 90102522
Nail disorder 116.08 10.20 541 397583 58526 90171797
International normalised ratio fluctuation 115.20 10.20 101 398023 2992 90227331
Onychomadesis 114.85 10.20 453 397671 45545 90184778
Hypoxia 114.50 10.20 90 398034 72309 90158014
Bradycardia 112.71 10.20 121 398003 83726 90146597
Multiple organ dysfunction syndrome 111.84 10.20 82 398042 68254 90162069
Overdose 111.66 10.20 339 397785 157370 90072953
Red blood cell sedimentation rate abnormal 111.39 10.20 294 397830 23910 90206413
Cognitive disorder 110.12 10.20 86 398038 69321 90161002
Wheezing 109.95 10.20 1560 396564 236520 89993803
Muscle injury 109.13 10.20 1222 396902 175432 90054891
Exostosis 109.11 10.20 493 397631 52641 90177682
Dislocation of vertebra 108.80 10.20 511 397613 55457 90174866
Lupus vulgaris 108.69 10.20 439 397685 44620 90185703
Urinary tract infection 108.06 10.20 842 397282 304790 89925533
Off label use 107.65 10.20 3863 394261 1098389 89131934
White blood cell count decreased 106.70 10.20 376 397748 166733 90063590
Cardio-respiratory arrest 105.65 10.20 74 398050 63066 90167257
Encephalopathy 105.61 10.20 36 398088 46408 90183915
Bone erosion 103.73 10.20 485 397639 52536 90177787
Hand deformity 103.36 10.20 1853 396271 294509 89935814
Neutrophil count decreased 103.28 10.20 97 398027 71435 90158888
Therapy non-responder 102.63 10.20 984 397140 135720 90094603
Pyrexia 102.37 10.20 2168 395956 658317 89572006
Epilepsy 101.66 10.20 664 397460 81542 90148781
Joint stiffness 101.20 10.20 638 397486 77404 90152919
Taste disorder 100.59 10.20 535 397589 61011 90169312
Sedation 100.13 10.20 43 398081 48128 90182195
Finger deformity 99.77 10.20 345 397779 32552 90197771
Gait disturbance 99.58 10.20 1653 396471 258843 89971480
Adjustment disorder with depressed mood 99.44 10.20 503 397621 56250 90174073
Intentional self-injury 98.65 10.20 8 398116 29326 90200997
Pulmonary embolism 97.85 10.20 274 397850 130546 90099777
Fall 96.45 10.20 1512 396612 480298 89750025
Chest discomfort 96.11 10.20 300 397824 138065 90092258
Pulmonary toxicity 93.87 10.20 176 397948 11355 90218968
Bloody discharge 92.63 10.20 78 398046 2185 90228138
Ulcer haemorrhage 92.33 10.20 290 397834 26031 90204292
Metabolic acidosis 90.87 10.20 67 398057 55609 90174714
COVID-19 90.59 10.20 407 397717 168436 90061887
Dysphagia 90.16 10.20 227 397897 112051 90118272
Migraine 90.08 10.20 1253 396871 189139 90041184
Product label confusion 89.77 10.20 262 397862 22588 90207735
Osteoporosis 87.99 10.20 725 397399 95806 90134517
Stomatitis 86.58 10.20 1691 396433 273007 89957316
Tachycardia 86.45 10.20 377 397747 157296 90073027
Oedema 85.20 10.20 1294 396830 199001 90031322
Bedridden 85.03 10.20 174 397950 11974 90218349
Sopor 84.92 10.20 6 398118 24638 90205685
Abdominal pain upper 84.60 10.20 1985 396139 330689 89899634
Hepatic cytolysis 83.50 10.20 17 398107 30899 90199424
Multiple sclerosis relapse 82.73 10.20 65 398059 52240 90178083
Epistaxis 81.62 10.20 156 397968 84969 90145354
Drug-induced liver injury 81.07 10.20 676 397448 89642 90140681
Chills 80.91 10.20 302 397822 131679 90098644
Blood parathyroid hormone decreased 80.86 10.20 171 397953 12045 90218278
Thyroid neoplasm 79.15 10.20 93 398031 3928 90226395
Ulcer 79.02 10.20 320 397804 32562 90197761
Hyperglycaemia 78.54 10.20 65 398059 50905 90179418
Cytokine release syndrome 78.49 10.20 14 398110 27959 90202364
Peripheral swelling 78.33 10.20 2372 395752 410734 89819589
Depressed level of consciousness 76.45 10.20 126 397998 72658 90157665
Premature baby 76.18 10.20 10 398114 25067 90205256
Blister 76.09 10.20 1557 396567 253441 89976882
Cholestasis 76.09 10.20 32 398092 36267 90194056
Colitis 75.42 10.20 119 398005 69823 90160500
Bone swelling 75.09 10.20 62 398062 1689 90228634
Plasma cell myeloma 74.97 10.20 43 398081 40785 90189538
Cardiac failure 74.92 10.20 239 397885 109257 90121066
Onychomycosis 74.66 10.20 344 397780 37032 90193291
Foetal death 74.54 10.20 4 398120 20719 90209604
Infection 74.07 10.20 2099 396025 359995 89870328
Device dislocation 74.06 10.20 23 398101 31459 90198864
Hypokalaemia 74.03 10.20 310 397814 130806 90099517
Drug resistance 73.89 10.20 21 398103 30428 90199895
Leukopenia 73.79 10.20 213 397911 100497 90129826
Granuloma skin 73.61 10.20 152 397972 10528 90219795
Drug ineffective for unapproved indication 73.19 10.20 112 398012 66532 90163791
General physical health deterioration 72.76 10.20 2059 396065 353056 89877267
Drug tolerance decreased 71.96 10.20 306 397818 31824 90198499
Orthostatic hypotension 71.33 10.20 48 398076 41779 90188544
Panniculitis 71.04 10.20 180 397944 14278 90216045
Balance disorder 70.63 10.20 206 397918 96874 90133449
Blood glucose increased 69.37 10.20 202 397922 95044 90135279
Anti-cyclic citrullinated peptide antibody positive 69.34 10.20 1440 396684 234993 89995330
Cytomegalovirus infection 69.06 10.20 16 398108 26586 90203737
Pleural fibrosis 68.85 10.20 82 398042 3514 90226809
Neoplasm malignant 68.55 10.20 313 397811 33567 90196756
Neoplasm progression 68.22 10.20 57 398067 44429 90185894
Pulmonary arterial hypertension 67.49 10.20 16 398108 26171 90204152
Ascites 67.44 10.20 66 398058 47674 90182649
Disability 67.13 10.20 355 397769 40390 90189933
Macular degeneration 66.90 10.20 42 398082 37928 90192395
Hypervolaemia 66.88 10.20 30 398094 32727 90197596
Hepatic enzyme increased 66.67 10.20 2065 396059 358671 89871652
Presbyacusis 66.02 10.20 74 398050 2968 90227355
Blood calcium decreased 65.89 10.20 25 398099 30157 90200166
Clostridium difficile colitis 65.59 10.20 18 398106 26688 90203635
Dysarthria 65.34 10.20 86 398038 54396 90175927
Cough 65.25 10.20 1184 396940 367778 89862545
Swelling 64.76 10.20 2349 395775 416709 89813614
Polyarthritis 64.20 10.20 202 397922 18148 90212175
Systemic lupus erythematosus rash 64.03 10.20 65 398059 2324 90227999
Mental status changes 64.01 10.20 61 398063 44618 90185705
Drug eruption 63.57 10.20 316 397808 35091 90195232
Hyperkalaemia 63.21 10.20 118 398006 64846 90165477
Fatigue 63.20 10.20 4295 393829 1149728 89080595
Coma 62.96 10.20 141 397983 72491 90157832
Blood bilirubin increased 62.69 10.20 59 398065 43411 90186912
International normalised ratio increased 61.70 10.20 70 398054 47246 90183077
Immobile 61.50 10.20 105 398019 6293 90224030
Clostridium difficile infection 61.27 10.20 42 398082 36203 90194120
Product quality issue 61.01 10.20 574 397550 78751 90151572
Joint destruction 60.74 10.20 161 397963 13126 90217197
Pharyngitis 60.43 10.20 223 397901 21724 90208599
Joint injury 60.41 10.20 294 397830 32370 90197953
Right ventricular failure 59.95 10.20 7 398117 19198 90211125
Gastrointestinal disorder 59.91 10.20 1514 396610 255173 89975150
Infusion site reaction 59.78 10.20 202 397922 18837 90211486
Gamma-glutamyltransferase increased 58.97 10.20 48 398076 37904 90192419
Acute respiratory failure 58.72 10.20 61 398063 42857 90187466
Gastrointestinal toxicity 58.63 10.20 129 397995 9338 90220985
Lethargy 58.55 10.20 118 398006 63021 90167302
Nerve injury 58.50 10.20 142 397982 10964 90219359
Liver function test increased 58.42 10.20 600 397524 84255 90146068
Hepatic failure 58.38 10.20 53 398071 39675 90190648
Dry skin 58.34 10.20 195 397929 87878 90142445
Muscle spasticity 58.30 10.20 42 398082 35280 90195043
Palmar-plantar erythrodysaesthesia syndrome 58.26 10.20 25 398099 27998 90202325
Lyme disease 57.84 10.20 82 398042 4180 90226143
Diarrhoea 57.61 10.20 3459 394665 935731 89294592
Cardiogenic shock 57.33 10.20 18 398106 24450 90205873
No adverse event 57.29 10.20 134 397990 67848 90162475
Suicidal ideation 57.23 10.20 152 397972 73703 90156620
Renal failure 57.16 10.20 339 397785 130668 90099655
Loss of employment 57.00 10.20 68 398056 2919 90227404
Intentional product use issue 56.88 10.20 1300 396824 215592 90014731
Dyspepsia 56.82 10.20 1203 396921 196957 90033366
Acute myeloid leukaemia 56.48 10.20 11 398113 20629 90209694
Rash erythematous 55.93 10.20 127 397997 64977 90165346
Insomnia 55.91 10.20 1887 396237 331587 89898736
Toothache 55.55 10.20 219 397905 22011 90208312
Pulmonary oedema 55.06 10.20 119 398005 61961 90168362
Flushing 54.54 10.20 202 397922 88289 90142034
Laryngitis 54.47 10.20 396 397728 50357 90179966
Torsade de pointes 54.39 10.20 3 398121 15179 90215144
Lower respiratory tract infection 54.30 10.20 1464 396660 249195 89981128
Walking aid user 54.21 10.20 303 397821 35203 90195120
Hyperhidrosis 54.17 10.20 363 397761 135942 90094381
Pleural thickening 54.02 10.20 69 398055 3179 90227144
Anti-cyclic citrullinated peptide antibody 53.97 10.20 250 397874 26971 90203352
Adverse reaction 53.92 10.20 266 397858 29446 90200877
Neutropenic sepsis 53.27 10.20 8 398116 18122 90212201
Injection site pain 53.06 10.20 497 397627 173202 90057121
Blood magnesium increased 52.94 10.20 70 398054 3338 90226985
Haematochezia 52.66 10.20 149 397975 70764 90159559
Sleep disorder due to general medical condition, insomnia type 52.62 10.20 826 397298 127868 90102455
Memory impairment 52.58 10.20 1185 396939 196059 90034264
Gastrooesophageal reflux disease 52.37 10.20 1024 397100 165313 90065010
Female genital tract fistula 52.23 10.20 8 398116 17860 90212463
Exposure during pregnancy 52.16 10.20 735 397389 237675 89992648
Pulmonary hypertension 52.15 10.20 66 398058 42457 90187866
Generalised tonic-clonic seizure 51.96 10.20 46 398078 34857 90195466
Creatinine renal clearance decreased 51.86 10.20 10 398114 18889 90211434
Pneumonia aspiration 51.84 10.20 62 398062 40878 90189445
Drug ineffective 51.51 10.20 6883 391241 1377415 88852908
Sedation complication 50.89 10.20 7 398117 16937 90213386
Drug reaction with eosinophilia and systemic symptoms 50.76 10.20 68 398056 42690 90187633
Glossodynia 50.73 10.20 1808 396316 319971 89910352
Diabetic ketoacidosis 50.38 10.20 22 398102 24385 90205938
Respiratory distress 50.36 10.20 58 398066 38888 90191435
Hypermobility syndrome 49.92 10.20 37 398087 857 90229466
Bunion operation 49.89 10.20 44 398080 1314 90229009
Therapy interrupted 49.65 10.20 90 398034 50018 90180305
Posterior reversible encephalopathy syndrome 49.61 10.20 18 398106 22321 90208002
Nausea 49.23 10.20 4205 393919 1106111 89124212
Skin necrosis 49.07 10.20 175 397949 16766 90213557
Pneumonitis 48.72 10.20 74 398050 44096 90186227
X-ray abnormal 48.51 10.20 354 397770 45070 90185253
Eosinophilia 48.31 10.20 33 398091 28500 90201823
Foot fracture 48.15 10.20 238 397886 26368 90203955
Full blood count decreased 48.09 10.20 36 398088 29653 90200670
Skin exfoliation 48.03 10.20 146 397978 67767 90162556
Unevaluable event 47.93 10.20 106 398018 54742 90175581
Eye injury 47.83 10.20 131 397993 10889 90219434
White blood cell count abnormal 47.32 10.20 103 398021 7401 90222922
Enthesopathy 47.17 10.20 118 398006 9286 90221037
Respiratory arrest 47.11 10.20 46 398078 33265 90197058
Acute hepatic failure 47.11 10.20 20 398104 22541 90207782
Lactic acidosis 47.05 10.20 94 398030 50369 90179954
Agitation 46.92 10.20 145 397979 66953 90163370
Chronic sinusitis 46.74 10.20 23 398101 23779 90206544
Palpitations 46.73 10.20 380 397744 136348 90093975
Psychotic disorder 46.68 10.20 41 398083 31189 90199134
Lymphocyte count decreased 46.63 10.20 51 398073 34999 90195324
Device difficult to use 46.58 10.20 10 398114 17515 90212808
Hip arthroplasty 46.49 10.20 526 397598 75682 90154641
Gastric disorder 46.47 10.20 278 397846 33106 90197217
Device issue 46.34 10.20 37 398087 29500 90200823
Pallor 46.25 10.20 49 398075 34116 90196207
Thrombotic microangiopathy 46.13 10.20 7 398117 15736 90214587
Nodule 45.68 10.20 235 397889 26451 90203872
Rhabdomyolysis 45.66 10.20 98 398026 51158 90179165
Therapeutic response decreased 45.47 10.20 598 397526 89131 90141192
Joint dislocation 45.09 10.20 343 397781 44239 90186084
Aphasia 45.06 10.20 74 398050 42738 90187585
Neurotoxicity 44.87 10.20 19 398105 21448 90208875
Pericarditis 44.58 10.20 1526 396598 268625 89961698
Hepatocellular injury 44.53 10.20 37 398087 28921 90201402
Sacroiliitis 44.25 10.20 72 398052 4147 90226176
Proctitis 44.22 10.20 7 398117 15252 90215071
Injection site erythema 43.97 10.20 253 397871 98249 90132074
Food allergy 43.77 10.20 29 398095 25449 90204874
Wrong technique in product usage process 43.70 10.20 164 397960 71407 90158916
Knee arthroplasty 43.68 10.20 558 397566 82624 90147699
Blood potassium decreased 43.57 10.20 90 398034 47637 90182686
Progressive multifocal leukoencephalopathy 43.57 10.20 8 398116 15647 90214676
Deformity 43.52 10.20 135 397989 12035 90218288
Agranulocytosis 43.27 10.20 54 398070 34948 90195375
Depression 43.26 10.20 1672 396452 298929 89931394
Myelodysplastic syndrome 42.90 10.20 19 398105 20884 90209439
Lupus-like syndrome 42.45 10.20 363 397761 48483 90181840
Rotator cuff syndrome 42.37 10.20 160 397964 15759 90214564
Heart rate increased 42.24 10.20 306 397818 112596 90117727
Fluid retention 41.65 10.20 222 397902 87869 90142454
Pericardial effusion 41.31 10.20 61 398063 36772 90193551
Paraesthesia oral 41.10 10.20 47 398077 31612 90198711
Status epilepticus 40.60 10.20 16 398108 18858 90211465
Joint effusion 40.55 10.20 183 397941 19527 90210796
Septic shock 40.40 10.20 211 397913 83949 90146374
Hallucination 40.36 10.20 151 397973 65808 90164515
Grip strength 40.34 10.20 108 398016 8857 90221466
Atrial fibrillation 40.07 10.20 384 397740 133227 90097096
Foot operation 40.07 10.20 108 398016 8893 90221430
Disorientation 39.58 10.20 84 398040 44030 90186293
Dyskinesia 39.54 10.20 62 398062 36472 90193851
Bone marrow failure 39.53 10.20 50 398074 32171 90198152
Chronic kidney disease 39.11 10.20 103 398021 50088 90180235
Polyneuropathy 39.04 10.20 18 398106 19323 90211000
Retinitis 38.96 10.20 296 397828 38162 90192161
Pleural effusion 38.84 10.20 310 397814 111681 90118642
Weight increased 38.78 10.20 2225 395899 415702 89814621
Ventricular tachycardia 38.70 10.20 31 398093 24677 90205646
Cardiotoxicity 38.59 10.20 3 398121 11386 90218937
Presyncope 38.35 10.20 50 398074 31755 90198568
Intervertebral disc protrusion 38.19 10.20 227 397897 26969 90203354
Haemoglobin decreased 38.05 10.20 492 397632 161464 90068859
Tenosynovitis 37.61 10.20 145 397979 14422 90215901
Ejection fraction decreased 37.42 10.20 36 398088 26217 90204106
Nasopharyngitis 37.31 10.20 2165 395959 404939 89825384
Bone cyst 37.18 10.20 49 398075 2329 90227994
Skin haemorrhage 37.18 10.20 24 398100 21356 90208967
Investigation abnormal 37.12 10.20 48 398076 2239 90228084
Mydriasis 37.09 10.20 10 398114 15002 90215321
Cerebral haemorrhage 36.96 10.20 59 398065 34463 90195860
Hyperbilirubinaemia 36.94 10.20 8 398116 13928 90216395
Electrolyte imbalance 36.93 10.20 30 398094 23715 90206608
Circulatory collapse 36.86 10.20 33 398091 24871 90205452
Psoriasis 36.69 10.20 879 397245 146875 90083448
Nephrolithiasis 36.65 10.20 353 397771 48732 90181591
Wound 36.50 10.20 1654 396470 301326 89928997
Porphyria acute 36.31 10.20 166 397958 17809 90212514
Burning mouth syndrome 36.03 10.20 26 398098 577 90229746
Haematotoxicity 35.77 10.20 6 398118 12529 90217794
Toxic epidermal necrolysis 35.39 10.20 55 398069 32473 90197850
Antinuclear antibody positive 35.38 10.20 105 398019 9136 90221187
Brain oedema 35.37 10.20 16 398108 17369 90212954
Lacrimation increased 35.32 10.20 40 398084 27022 90203301
Vision blurred 35.23 10.20 312 397812 109981 90120342
Metastases to bone 35.18 10.20 36 398088 25469 90204854
Wrist deformity 34.97 10.20 56 398068 3182 90227141
Schizophrenia 34.89 10.20 11 398113 14903 90215420
Transplant rejection 34.49 10.20 7 398117 12751 90217572
Pneumonia 34.37 10.20 2377 395747 635682 89594641
Poisoning 34.24 10.20 12 398112 15205 90215118
Adverse event 33.69 10.20 713 397411 116705 90113618
Blood folate decreased 33.50 10.20 39 398085 1631 90228692
Intentional product misuse 33.45 10.20 243 397881 89361 90140962
Dysstasia 33.21 10.20 206 397918 24846 90205477
Affect lability 33.20 10.20 19 398105 18044 90212279
Dyspnoea exertional 33.17 10.20 184 397940 72104 90158219
Aggression 33.11 10.20 41 398083 26627 90203696
Tachypnoea 33.05 10.20 27 398097 21282 90209041
Dysgeusia 33.03 10.20 119 398005 52441 90177882
Metastases to liver 33.00 10.20 47 398077 28760 90201563
Epigastric discomfort 32.88 10.20 90 398034 7478 90222845
Premature labour 32.88 10.20 9 398115 13367 90216956
Haemodynamic instability 32.66 10.20 6 398118 11733 90218590
Myocarditis 32.63 10.20 10 398114 13796 90216527
Hepatic encephalopathy 32.50 10.20 10 398114 13762 90216561
Eczema 32.37 10.20 121 398003 52749 90177574
Thrombosis 32.23 10.20 189 397935 73062 90157261
Drug level increased 32.10 10.20 45 398079 27717 90202606
Depressed mood 32.03 10.20 113 398011 50109 90180214
Hypoalbuminaemia 31.77 10.20 15 398109 15882 90214441
Ventricular fibrillation 31.73 10.20 11 398113 14033 90216290
Gastric ulcer 31.69 10.20 218 397906 27230 90203093
Extrapyramidal disorder 31.64 10.20 16 398108 16287 90214036
Osteosclerosis 31.57 10.20 63 398061 4257 90226066
Motor dysfunction 31.56 10.20 23 398101 19207 90211116
Infective pulmonary exacerbation of cystic fibrosis 31.46 10.20 4 398120 10275 90220048
Injection site reaction 31.42 10.20 574 397550 91506 90138817
Cerebrovascular accident 31.38 10.20 369 397755 123164 90107159
Deafness neurosensory 31.38 10.20 83 398041 6758 90223565
Aspergillus infection 31.29 10.20 5 398119 10818 90219505
Restlessness 31.24 10.20 69 398055 35651 90194672
Dysphonia 30.93 10.20 157 397967 62927 90167396
Seronegative arthritis 30.81 10.20 160 397964 18074 90212249
Left ventricular dysfunction 30.63 10.20 13 398111 14656 90215667
Therapy partial responder 30.53 10.20 31 398093 22012 90208311
Hallucination, auditory 30.53 10.20 16 398108 15959 90214364
Hypothyroidism 30.35 10.20 125 397999 53002 90177321
Impaired work ability 30.22 10.20 166 397958 19160 90211163
Intervertebral disc degeneration 30.18 10.20 153 397971 17121 90213202
Bacteraemia 30.17 10.20 32 398092 22268 90208055
Chronic obstructive pulmonary disease 30.14 10.20 195 397929 73634 90156689
Parkinsonism 30.12 10.20 12 398112 14053 90216270
Oxygen saturation decreased 30.11 10.20 314 397810 107169 90123154
Hyperthyroidism 29.92 10.20 22 398102 18288 90212035
Coordination abnormal 29.62 10.20 30 398094 21326 90208997
Epicondylitis 29.59 10.20 46 398078 2548 90227775
Blood pressure decreased 29.48 10.20 200 397924 74695 90155628
Full blood count abnormal 29.36 10.20 74 398050 36523 90193800
Serotonin syndrome 29.33 10.20 78 398046 37809 90192514
Accidental exposure to product 29.30 10.20 92 398032 42274 90188049
Ankle arthroplasty 29.27 10.20 48 398076 2783 90227540
Stress cardiomyopathy 29.26 10.20 11 398113 13344 90216979
Abortion induced 29.22 10.20 8 398116 11880 90218443
Respiratory depression 29.17 10.20 16 398108 15559 90214764
Dysuria 29.10 10.20 83 398041 39318 90191005
Dystonia 29.09 10.20 19 398105 16800 90213523
Hepatic cirrhosis 28.96 10.20 414 397710 62839 90167484
Aplastic anaemia 28.95 10.20 11 398113 13258 90217065
Haemorrhage 28.94 10.20 182 397942 69187 90161136
Pancreatitis acute 28.94 10.20 61 398063 32054 90198269
Basal cell carcinoma 28.94 10.20 248 397876 33141 90197182
Injection site swelling 28.73 10.20 150 397974 59689 90170634
Disturbance in attention 28.72 10.20 108 398016 47001 90183322
Coagulopathy 28.71 10.20 36 398088 23253 90207070
Suspected suicide 28.63 10.20 4 398120 9564 90220759
Axial spondyloarthritis 28.44 10.20 23 398101 608 90229715
Sinus tachycardia 28.44 10.20 51 398073 28462 90201861
Nasal congestion 28.41 10.20 232 397892 83182 90147141
Caesarean section 28.24 10.20 24 398100 18553 90211770
Hemiparesis 28.21 10.20 61 398063 31758 90198565
Gestational diabetes 28.20 10.20 6 398118 10576 90219747
Blood lactate dehydrogenase increased 28.07 10.20 44 398080 25888 90204435
Procedural pain 27.91 10.20 66 398058 33294 90197029
Rebound effect 27.89 10.20 4 398120 9380 90220943
Delusion 27.75 10.20 13 398111 13827 90216496
Blood creatinine increased 27.66 10.20 298 397826 101088 90129235
Vascular device infection 27.63 10.20 9 398115 11943 90218380
Genital haemorrhage 27.59 10.20 3 398121 8699 90221624
Skin discolouration 27.41 10.20 101 398023 44214 90186109
Nasal polyps 27.35 10.20 7 398117 10873 90219450
Residual urine volume increased 27.35 10.20 12 398112 95 90230228
Cytopenia 27.20 10.20 22 398102 17427 90212896
Fine motor skill dysfunction 27.18 10.20 68 398056 5351 90224972
Eye pruritus 27.12 10.20 54 398070 28973 90201350
Infusion site pain 27.06 10.20 28 398096 19710 90210613
Febrile bone marrow aplasia 27.05 10.20 5 398119 9733 90220590
Musculoskeletal disorder 27.00 10.20 176 397948 21593 90208730
Pain 27.00 10.20 4869 393255 991472 89238851
Sinus bradycardia 26.89 10.20 21 398103 16931 90213392
Delirium 26.87 10.20 624 397500 103735 90126588
Intestinal obstruction 26.85 10.20 79 398045 37052 90193271
Systemic lupus erythematosus 26.48 10.20 1888 396236 360008 89870315
Myalgia 26.38 10.20 577 397547 174548 90055775
Blood alkaline phosphatase increased 26.31 10.20 115 398009 47964 90182359
Impaired quality of life 26.28 10.20 38 398086 23106 90207217
Muscle twitching 26.26 10.20 41 398083 24161 90206162
Entropion 26.22 10.20 12 398112 106 90230217
Maternal exposure timing unspecified 26.21 10.20 179 397945 22304 90208019
Neuroleptic malignant syndrome 26.18 10.20 17 398107 15079 90215244
Hallucination, visual 26.13 10.20 38 398086 23054 90207269
Transfusion 26.09 10.20 23 398101 17465 90212858
Erythema 26.08 10.20 787 397337 228459 90001864
Vaginal haemorrhage 26.05 10.20 62 398062 31209 90199114
Arterial occlusive disease 26.04 10.20 11 398113 12435 90217888
Low birth weight baby 26.00 10.20 5 398119 9462 90220861
Enterococcal infection 25.95 10.20 6 398118 9985 90220338
Respiratory syncytial virus infection 25.86 10.20 7 398117 10473 90219850
Abnormal behaviour 25.84 10.20 37 398087 22591 90207732
Spinal osteoarthritis 25.73 10.20 158 397966 18990 90211333
Hepatic enzyme 25.70 10.20 66 398058 5278 90225045
Hepatitis 25.57 10.20 445 397679 70294 90160029
Hypomagnesaemia 25.53 10.20 76 398048 35512 90194811
Deep vein thrombosis 25.52 10.20 268 397856 91352 90138971
Haematoma 25.48 10.20 87 398037 38961 90191362
Skin ulcer 25.48 10.20 334 397790 49741 90180582
Pseudomonas infection 25.43 10.20 17 398107 14848 90215475
Mental disorder 25.42 10.20 66 398058 32252 90198071
Acute respiratory distress syndrome 25.42 10.20 55 398069 28631 90201692
Device malfunction 25.27 10.20 33 398091 20944 90209379
Therapy cessation 25.12 10.20 79 398045 36282 90194041
Sinus disorder 25.12 10.20 73 398051 34374 90195949
Muscle spasms 24.70 10.20 1348 396776 250535 89979788
Liver function test abnormal 24.67 10.20 127 397997 50718 90179605
Exposure to toxic agent 24.63 10.20 3 398121 7964 90222359
Leukocytosis 24.60 10.20 63 398061 30927 90199396
Hypersensitivity 24.59 10.20 2318 395806 452359 89777964
Carotid artery thrombosis 24.55 10.20 5 398119 9087 90221236
Gangrene 24.45 10.20 13 398111 12863 90217460
Body temperature increased 24.43 10.20 107 398017 44603 90185720
Renal tubular necrosis 24.42 10.20 17 398107 14538 90215785
Myocardial infarction 24.38 10.20 624 397500 105348 90124975
Nightmare 24.34 10.20 36 398088 21689 90208634
Irritability 24.27 10.20 78 398046 35584 90194739
Hospitalisation 24.23 10.20 406 397718 127694 90102629
Blood creatine phosphokinase increased 24.16 10.20 73 398051 33950 90196373
Amnesia 24.11 10.20 636 397488 107869 90122454
Synovial cyst 24.09 10.20 109 398015 11643 90218680
Hypotonia 24.06 10.20 10 398114 11416 90218907
Anuria 23.96 10.20 18 398106 14800 90215523
Swollen joint count 23.89 10.20 88 398036 8565 90221758
Complication of device insertion 23.88 10.20 8 398116 10428 90219895
Jaw clicking 23.86 10.20 11 398113 99 90230224
Productive cough 23.73 10.20 220 397904 76843 90153480
Iritis 23.71 10.20 51 398073 3635 90226688
Blood sodium decreased 23.61 10.20 54 398070 27559 90202764
Klebsiella infection 23.38 10.20 8 398116 10289 90220034
Movement disorder 23.32 10.20 212 397912 28807 90201516
Unintended pregnancy 23.31 10.20 3 398121 7634 90222689
Fracture pain 23.29 10.20 27 398097 1124 90229199
Rheumatoid lung 23.28 10.20 54 398070 4049 90226274
Device related infection 23.22 10.20 49 398075 25737 90204586
Inappropriate antidiuretic hormone secretion 23.17 10.20 31 398093 19474 90210849
Eating disorder 23.12 10.20 56 398068 28017 90202306
Mania 23.04 10.20 17 398107 14107 90216216
Headache 23.00 10.20 3382 394742 859364 89370959
Acute generalised exanthematous pustulosis 23.00 10.20 16 398108 13687 90216636
Personality disorder 23.00 10.20 13 398111 12431 90217892
Uterine perforation 22.98 10.20 3 398121 7551 90222772
Pathogen resistance 22.90 10.20 4 398120 8111 90222212
Muscular weakness 22.90 10.20 1119 397005 205547 90024776
Adjustment disorder 22.76 10.20 7 398117 9635 90220688
Rhinorrhoea 22.74 10.20 263 397861 88053 90142270
Metastases to lung 22.71 10.20 22 398102 15969 90214354
Hypothermia 22.62 10.20 21 398103 15554 90214769
COVID-19 pneumonia 22.51 10.20 28 398096 18149 90212174
Shock 22.46 10.20 59 398065 28719 90201604
Bronchopulmonary aspergillosis 22.40 10.20 11 398113 11387 90218936
Subdural haematoma 22.39 10.20 24 398100 16621 90213702
Device leakage 22.27 10.20 8 398116 9983 90220340
Retching 22.21 10.20 31 398093 19128 90211195
Transaminases increased 22.20 10.20 86 398038 37106 90193217
Multiple fractures 22.14 10.20 92 398032 9470 90220853
Paranasal sinus inflammation 22.08 10.20 20 398104 619 90229704
Injection site pruritus 22.07 10.20 142 397982 53692 90176631
Accidental overdose 22.04 10.20 58 398066 28215 90202108
Sneezing 22.00 10.20 63 398061 29806 90200517
Overlap syndrome 22.00 10.20 85 398039 8463 90221860
Vomiting 21.95 10.20 3082 395042 785211 89445112
Incorrect dose administered 21.93 10.20 231 397893 78699 90151624
Tendonitis 21.93 10.20 165 397959 21207 90209116
Hypomania 21.84 10.20 6 398118 8891 90221432
Hunger 21.82 10.20 71 398053 6492 90223831
Blood magnesium decreased 21.81 10.20 22 398102 15671 90214652
Partial seizures 21.80 10.20 3 398121 7257 90223066
Feeling cold 21.67 10.20 56 398068 27409 90202914
Spondylitis 21.64 10.20 121 398003 14057 90216266
Unresponsive to stimuli 21.59 10.20 90 398034 38031 90192292
Multiple-drug resistance 21.58 10.20 4 398120 7772 90222551
Product administration error 21.53 10.20 53 398071 26370 90203953
Device breakage 21.52 10.20 18 398106 14026 90216297
Rash macular 21.48 10.20 65 398059 30215 90200108
Infusion related reaction 21.38 10.20 2117 396007 414663 89815660
Haematuria 21.36 10.20 80 398044 34857 90195466
Abdominal discomfort 21.31 10.20 2402 395722 474926 89755397
Vulvovaginal erythema 21.30 10.20 19 398105 576 90229747
Nephropathy toxic 21.05 10.20 15 398109 12673 90217650
Oesophageal spasm 21.04 10.20 46 398078 3315 90227008
Blood glucose decreased 20.70 10.20 45 398079 23384 90206939
Breast cyst excision 20.65 10.20 9 398115 70 90230253
Cyst 20.60 10.20 134 397990 16427 90213896
Fear of injection 20.56 10.20 83 398041 8432 90221891
Osteopenia 20.54 10.20 172 397952 22830 90207493
Miosis 20.46 10.20 8 398116 9476 90220847
Meniscus injury 20.46 10.20 81 398043 8156 90222167
Atrioventricular block first degree 20.41 10.20 6 398118 8505 90221818
Proteinuria 20.36 10.20 45 398079 23246 90207077
Hypovolaemia 20.23 10.20 15 398109 12416 90217907
Obstructive airways disorder 20.22 10.20 53 398071 25816 90204507
Escherichia infection 20.20 10.20 24 398100 15871 90214452
Psychomotor hyperactivity 20.16 10.20 16 398108 12797 90217526
Vulvovaginal swelling 20.14 10.20 21 398103 775 90229548
Cyanosis 20.13 10.20 34 398090 19421 90210902
Joint prosthesis user 20.10 10.20 8 398116 48 90230275
Gastric ulcer haemorrhage 20.01 10.20 60 398064 5251 90225072
Drug dose omission by device 19.92 10.20 10 398114 10221 90220102
Hemiplegia 19.90 10.20 25 398099 16135 90214188
Feeding disorder 19.64 10.20 29 398095 17483 90212840
Coeliac disease 19.64 10.20 290 397834 44320 90186003
Dermatitis allergic 19.64 10.20 137 397987 17190 90213133
Shock haemorrhagic 19.64 10.20 15 398109 12230 90218093
Underdose 19.59 10.20 340 397784 53677 90176646
Amblyopia 19.51 10.20 14 398110 308 90230015
Lung adenocarcinoma stage IV 19.44 10.20 16 398108 434 90229889
Limb discomfort 19.42 10.20 254 397870 37806 90192517
Haemoptysis 19.28 10.20 78 398046 33242 90197081
Splenomegaly 19.28 10.20 17 398107 12907 90217416
Haemorrhage intracranial 19.15 10.20 23 398101 15139 90215184
Dermatitis contact 18.96 10.20 19 398105 13576 90216747
Haemophagocytic lymphohistiocytosis 18.95 10.20 24 398100 15435 90214888
Bronchiectasis 18.82 10.20 44 398080 22286 90208037
Akathisia 18.77 10.20 13 398111 11146 90219177
Synovial disorder 18.76 10.20 42 398082 3076 90227247
Tumour lysis syndrome 18.75 10.20 13 398111 11139 90219184
Pharyngeal oedema 18.73 10.20 114 398010 13657 90216666
Gelatinous transformation of the bone marrow 18.72 10.20 5 398119 5 90230318
Hyperammonaemia 18.70 10.20 3 398121 6472 90223851
Malnutrition 18.68 10.20 33 398091 18525 90211798
Staphylococcal sepsis 18.53 10.20 9 398115 9374 90220949
Atrioventricular block complete 18.49 10.20 10 398114 9801 90220522
Hypertensive crisis 18.47 10.20 31 398093 17753 90212570
Nail injury 18.33 10.20 20 398104 778 90229545
Sensory loss 18.32 10.20 32 398092 18043 90212280
Failure to thrive 18.31 10.20 7 398117 8404 90221919
Hepatic steatosis 18.20 10.20 245 397879 36700 90193623
Neutrophil count increased 18.18 10.20 36 398088 19354 90210969
Synovial fluid analysis 18.13 10.20 39 398085 2779 90227544
Serum ferritin increased 18.08 10.20 5 398119 7376 90222947
Peripheral sensory neuropathy 18.07 10.20 9 398115 9241 90221082
Rash papular 18.06 10.20 39 398085 20316 90210007
Breast cancer metastatic 18.03 10.20 24 398100 15108 90215215
Dialysis 18.01 10.20 14 398110 11315 90219008
Blood lactic acid increased 17.98 10.20 8 398116 8770 90221553
Abnormal loss of weight 17.92 10.20 4 398120 6819 90223504
Illness 17.80 10.20 253 397871 81716 90148607
Bradykinesia 17.79 10.20 4 398120 6784 90223539
Product storage error 17.78 10.20 39 398085 20202 90210121
Sickle cell anaemia with crisis 17.77 10.20 5 398119 7292 90223031
Malaise 17.72 10.20 2881 395243 583105 89647218
Cardiomyopathy 17.69 10.20 39 398085 20167 90210156
Dermatitis atopic 17.66 10.20 49 398075 23423 90206900
Vaginal discharge 17.51 10.20 37 398087 19427 90210896
Wrong product administered 17.32 10.20 6 398118 7659 90222664
Loss of consciousness 17.31 10.20 476 397648 139762 90090561
Glycosylated haemoglobin increased 17.23 10.20 26 398098 15536 90214787
Pruritus allergic 17.22 10.20 29 398095 1719 90228604
Angioedema 17.17 10.20 192 397932 64684 90165639
Tenosynovitis stenosans 17.16 10.20 47 398077 3906 90226417
Postoperative adhesion 17.15 10.20 15 398109 443 90229880
Glomerular filtration rate decreased 17.14 10.20 30 398094 16902 90213421
Apathy 17.11 10.20 14 398110 11026 90219297
Blood test abnormal 17.09 10.20 42 398082 20910 90209413
Hypernatraemia 17.07 10.20 10 398114 9377 90220946
Nasal oedema 17.01 10.20 4 398120 6580 90223743
Metastases to central nervous system 16.94 10.20 32 398092 17510 90212813
Paranoia 16.93 10.20 19 398105 12889 90217434
Altered state of consciousness 16.90 10.20 76 398048 31456 90198867
Pulmonary alveolar haemorrhage 16.83 10.20 3 398121 5995 90224328
Venoocclusive liver disease 16.81 10.20 3 398121 5990 90224333
Blindness 16.79 10.20 60 398064 26508 90203815
Dactylitis 16.77 10.20 46 398078 3827 90226496
Ileal ulcer 16.72 10.20 22 398102 1044 90229279
Multiple drug therapy 16.70 10.20 5 398119 7004 90223319
Iron deficiency 16.70 10.20 85 398039 9527 90220796
Pneumonia viral 16.62 10.20 9 398115 8814 90221509
Myopathy 16.56 10.20 21 398103 13497 90216826
Alanine aminotransferase abnormal 16.53 10.20 57 398067 5369 90224954
Flatulence 16.51 10.20 110 398014 41257 90189066
Jaundice cholestatic 16.50 10.20 12 398112 10031 90220292
Pollakiuria 16.26 10.20 82 398042 32923 90197400
Ischaemic stroke 16.14 10.20 47 398077 22119 90208204
Hepatomegaly 16.01 10.20 21 398103 13305 90217018
Tuberculin test positive 15.89 10.20 44 398080 3681 90226642
Mass excision 15.87 10.20 13 398111 350 90229973
Spinal flattening 15.86 10.20 12 398112 287 90230036
Ageusia 15.81 10.20 29 398095 16047 90214276
Escherichia bacteraemia 15.81 10.20 3 398121 5732 90224591
Treatment noncompliance 15.78 10.20 148 397976 51579 90178744
Mood swings 15.74 10.20 43 398081 20659 90209664
Carbuncle 15.73 10.20 25 398099 1411 90228912
Body height decreased 15.68 10.20 98 398026 11851 90218472
Infusion site swelling 15.65 10.20 17 398107 11703 90218620
Hepatic function abnormal 15.64 10.20 129 397995 46159 90184164
Maternal exposure during breast feeding 15.64 10.20 4 398120 6216 90224107
Tooth infection 15.52 10.20 146 397978 20024 90210299
Vitamin B12 decreased 15.50 10.20 55 398069 5255 90225068
Catheter site infection 15.50 10.20 3 398121 5651 90224672
Urosepsis 15.48 10.20 45 398079 21187 90209136
Abdominal pain lower 15.43 10.20 74 398050 30103 90200220
Disability assessment scale score increased 15.37 10.20 45 398079 3886 90226437
Jaundice 15.34 10.20 82 398042 32435 90197888
Maternal exposure before pregnancy 15.27 10.20 16 398108 11197 90219126
Oropharyngeal pain 15.26 10.20 387 397737 114800 90115523
Upper-airway cough syndrome 15.16 10.20 27 398097 15108 90215215
Red blood cell sedimentation rate 15.14 10.20 50 398074 4608 90225715
Complication associated with device 15.08 10.20 40 398084 19409 90210914
Bone pain 15.03 10.20 187 397937 61796 90168527
Bronchospasm 15.02 10.20 44 398080 20665 90209658
Thrombocytosis 14.95 10.20 6 398118 6995 90223328
Synovial rupture 14.91 10.20 12 398112 315 90230008
Diabetes mellitus inadequate control 14.82 10.20 38 398086 18646 90211677
Salivary hypersecretion 14.76 10.20 11 398113 9081 90221242
Anosmia 14.63 10.20 13 398111 9835 90220488
Vertigo 14.63 10.20 217 397907 69594 90160729
Gingival bleeding 14.56 10.20 27 398097 14876 90215447
Spinal fusion surgery 14.44 10.20 98 398026 12185 90218138
Myoclonus 14.43 10.20 40 398084 19128 90211195
Hallucinations, mixed 14.40 10.20 4 398120 5885 90224438
Rash maculo-papular 14.33 10.20 113 398011 40820 90189503
Lip swelling 14.26 10.20 105 398019 38505 90191818
Haemolysis 14.20 10.20 10 398114 8500 90221823
Paraesthesia 14.08 10.20 1280 396844 249046 89981277
Small intestinal obstruction 14.07 10.20 47 398077 21187 90209136
Pemphigus 14.05 10.20 1641 396483 325223 89905100
Somatic symptom disorder 14.04 10.20 40 398084 3401 90226922
Head injury 13.97 10.20 80 398044 31108 90199215
Complication of device removal 13.96 10.20 5 398119 6250 90224073
Pulmonary haemorrhage 13.93 10.20 9 398115 8004 90222319
Injection site mass 13.89 10.20 50 398074 22040 90208283
Panic attack 13.86 10.20 64 398060 26301 90204022
Hyperthermia 13.79 10.20 15 398109 10320 90220003
Milk-alkali syndrome 13.73 10.20 22 398102 1251 90229072
Respiratory tract infection 13.67 10.20 180 397944 58898 90171425
Patellofemoral pain syndrome 13.66 10.20 17 398107 763 90229560
Peritonitis bacterial 13.64 10.20 3 398121 5168 90225155
Genital ulceration 13.62 10.20 20 398104 1053 90229270
Tongue disorder 13.59 10.20 88 398036 10772 90219551
Staphylococcal bacteraemia 13.52 10.20 8 398116 7461 90222862
Sinusitis 13.51 10.20 1713 396411 341375 89888948
Renal impairment 13.48 10.20 356 397768 105065 90125258
Cervical radiculopathy 13.46 10.20 23 398101 1379 90228944
Multiple allergies 13.45 10.20 29 398095 15117 90215206
Rhinitis allergic 13.42 10.20 34 398090 16751 90213572
Eosinophil count increased 13.41 10.20 23 398101 13058 90217265
Hypocholesterolaemia 13.36 10.20 60 398064 6389 90223934
Throat irritation 13.33 10.20 143 397981 48552 90181771
Ataxia 13.33 10.20 38 398086 18004 90212319
Myofascial pain syndrome 13.30 10.20 36 398088 2971 90227352
Dressler's syndrome 13.30 10.20 3 398121 0 90230323
Spinal retrolisthesis 13.30 10.20 3 398121 0 90230323
Fracture 13.29 10.20 152 397972 21924 90208399
Cartilage injury 13.15 10.20 29 398095 2102 90228221
Hypophagia 13.15 10.20 98 398026 35839 90194484
Malignant polyp 13.07 10.20 9 398115 185 90230138
Inappropriate schedule of product administration 13.06 10.20 532 397592 149401 90080922
Hospice care 13.04 10.20 14 398110 9690 90220633
Thirst 13.03 10.20 33 398091 16262 90214061
Breast cancer stage II 13.03 10.20 223 397901 35111 90195212
Troponin increased 13.03 10.20 24 398100 13257 90217066
Subarachnoid haemorrhage 13.01 10.20 38 398086 17866 90212457
Tuberculosis 12.94 10.20 97 398027 12452 90217871
Osteogenesis imperfecta 12.93 10.20 18 398106 902 90229421
Rhabdoid tumour 12.92 10.20 6 398118 55 90230268
Labelled drug-drug interaction medication error 12.89 10.20 28 398096 14554 90215769
Anal incontinence 12.88 10.20 33 398091 16197 90214126
Vulval disorder 12.84 10.20 22 398102 1322 90229001
Blood albumin decreased 12.70 10.20 35 398089 16768 90213555
Oligohydramnios 12.64 10.20 8 398116 7193 90223130
Substance abuse 12.62 10.20 4 398120 5402 90224921
Pain of skin 12.53 10.20 33 398091 16049 90214274
Injection site rash 12.52 10.20 59 398065 24114 90206209
Haemolytic anaemia 12.51 10.20 20 398104 11677 90218646
Acidosis 12.50 10.20 23 398101 12713 90217610
Epiploic appendagitis 12.50 10.20 7 398117 98 90230225
Monocyte count increased 12.36 10.20 13 398111 9084 90221239
Asphyxia 12.32 10.20 8 398116 7095 90223228
Haemoglobin abnormal 12.31 10.20 8 398116 7092 90223231
Swelling face 12.26 10.20 268 397856 81084 90149239
Hepatitis acute 12.24 10.20 18 398106 10869 90219454
Eructation 12.22 10.20 18 398106 10864 90219459
Forced vital capacity abnormal 12.22 10.20 6 398118 63 90230260
Hip fracture 12.20 10.20 90 398034 32987 90197336
Metabolic disorder 12.17 10.20 9 398115 7461 90222862
Diplopia 12.15 10.20 75 398049 28639 90201684
Systemic infection 12.14 10.20 3 398121 4772 90225551
Iron deficiency anaemia 12.11 10.20 58 398066 23604 90206719
Hot flush 12.09 10.20 186 397938 59302 90171021
Pneumonia fungal 12.08 10.20 8 398116 7023 90223300
Immune reconstitution inflammatory syndrome 12.04 10.20 8 398116 7011 90223312
Speech disorder 12.03 10.20 135 397989 45450 90184873
Endoscopic retrograde cholangiopancreatography 12.01 10.20 9 398115 212 90230111
Rales 11.94 10.20 33 398091 15794 90214529
Skin fissures 11.86 10.20 49 398075 20760 90209563
Escherichia urinary tract infection 11.82 10.20 27 398097 13788 90216535
Autoimmune haemolytic anaemia 11.79 10.20 5 398119 5640 90224683
Maternal exposure during pregnancy 11.78 10.20 1393 396731 358670 89871653
Stevens-Johnson syndrome 11.78 10.20 78 398046 29298 90201025
Urine abnormality 11.76 10.20 10 398114 7727 90222596
Medulloblastoma 11.74 10.20 6 398118 69 90230254
Bronchomalacia 11.73 10.20 9 398115 220 90230103
Infusion site extravasation 11.68 10.20 17 398107 10311 90220012
Product adhesion issue 11.66 10.20 4 398120 5138 90225185
Breath sounds abnormal 11.66 10.20 111 398013 15275 90215048
Blood calcium increased 11.64 10.20 22 398102 12036 90218287
Tendinous contracture 11.63 10.20 8 398116 164 90230159
Visual acuity reduced 11.62 10.20 58 398066 23352 90206971
Anger 11.59 10.20 27 398097 13693 90216630
Angina pectoris 11.54 10.20 113 398011 39047 90191276
Bone marrow oedema 11.50 10.20 22 398102 1441 90228882
Oedema peripheral 11.45 10.20 976 397148 256939 89973384
Blood thyroid stimulating hormone increased 11.45 10.20 14 398110 9141 90221182
Acute myocardial infarction 11.45 10.20 98 398026 34792 90195531
Lip and/or oral cavity cancer 11.44 10.20 17 398107 905 90229418
Food aversion 11.43 10.20 21 398103 1334 90228989
Nystagmus 11.40 10.20 9 398115 7218 90223105
Tongue cancer recurrent 11.36 10.20 4 398120 16 90230307
Pulmonary congestion 11.34 10.20 133 397991 19300 90211023
Pruritus genital 11.33 10.20 3 398121 4555 90225768
Breast cancer recurrent 11.30 10.20 5 398119 5498 90224825
Weight decreased 11.29 10.20 1479 396645 378431 89851892
Pelvic fracture 11.28 10.20 32 398092 15187 90215136
Respiration abnormal 11.26 10.20 11 398113 7952 90222371
Neuroprosthesis implantation 11.23 10.20 3 398121 3 90230320
Carotid artery occlusion 11.19 10.20 7 398117 6335 90223988
Therapy change 11.19 10.20 12 398112 8310 90222013
Intestinal perforation 11.19 10.20 28 398096 13853 90216470
Injection site urticaria 11.17 10.20 41 398083 17970 90212353
Dizziness postural 11.15 10.20 14 398110 9039 90221284
Sciatic nerve neuropathy 11.12 10.20 12 398112 461 90229862
Allergy to chemicals 11.06 10.20 39 398085 3715 90226608
Coronary artery surgery 11.04 10.20 5 398119 43 90230280
Hip surgery 11.03 10.20 42 398082 4153 90226170
Hypothalamo-pituitary disorder 11.02 10.20 28 398096 2224 90228099
Lipase increased 10.97 10.20 20 398104 11091 90219232
Aspiration 10.91 10.20 34 398090 15659 90214664
Pelvic pain 10.87 10.20 33 398091 15324 90214999
End stage renal disease 10.83 10.20 13 398111 8558 90221765
Autoimmune hepatitis 10.79 10.20 18 398106 10333 90219990
Femur fracture 10.79 10.20 272 397852 45810 90184513
Epstein-Barr virus infection 10.77 10.20 18 398106 10326 90219997
Normal newborn 10.73 10.20 153 397971 23209 90207114
Sarcoidosis 10.72 10.20 19 398105 10654 90219669
Drug dependence 10.72 10.20 80 398044 29247 90201076
Feeling abnormal 10.70 10.20 613 397511 166622 90063701
Paradoxical drug reaction 10.69 10.20 6 398118 5760 90224563
Infusion site erythema 10.69 10.20 28 398096 13642 90216681
Intestinal ischaemia 10.67 10.20 14 398110 8869 90221454
Product dose omission in error 10.64 10.20 50 398074 20453 90209870
Influenza like illness 10.63 10.20 271 397853 80340 90149983
Lymphopenia 10.63 10.20 58 398066 22823 90207500
Acute pulmonary oedema 10.61 10.20 16 398108 9564 90220759
Central nervous system lesion 10.60 10.20 22 398102 11624 90218699
Incorrect dose administered by device 10.59 10.20 6 398118 5731 90224592
Weight fluctuation 10.58 10.20 133 397991 19616 90210707
Vascular graft infection 10.57 10.20 5 398119 48 90230275
Lupus nephritis 10.55 10.20 4 398120 4828 90225495
Throat tightness 10.50 10.20 81 398043 29403 90200920
Tardive dyskinesia 10.50 10.20 20 398104 10910 90219413
Lithotripsy 10.49 10.20 4 398120 21 90230302
Atrioventricular block 10.48 10.20 14 398110 8801 90221522
Lung neoplasm malignant 10.48 10.20 63 398061 24210 90206113
Personality change 10.48 10.20 10 398114 7311 90223012
Vitamin K deficiency 10.48 10.20 12 398112 493 90229830
Coeliac artery compression syndrome 10.46 10.20 7 398117 137 90230186
Meningitis streptococcal 10.42 10.20 7 398117 138 90230185
Hypersensitivity vasculitis 10.41 10.20 41 398083 4118 90226205
Spinal cord injury 10.40 10.20 18 398106 1091 90229232
Cholecystitis chronic 10.33 10.20 17 398107 9809 90220514
Influenza 10.32 10.20 503 397621 138761 90091562
Periarticular disorder 10.31 10.20 5 398119 51 90230272
Adrenal suppression 10.29 10.20 17 398107 992 90229331
Alanine aminotransferase increased 10.28 10.20 420 397704 117918 90112405
Dementia 10.27 10.20 62 398062 23799 90206524
Catatonia 10.26 10.20 7 398117 6049 90224274
Pulse absent 10.26 10.20 7 398117 6048 90224275
Head discomfort 10.25 10.20 37 398087 16296 90214027
Ear infection 10.23 10.20 389 397735 69386 90160937
Aplasia pure red cell 10.23 10.20 5 398119 5189 90225134
Acute coronary syndrome 10.20 10.20 20 398104 10793 90219530

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 571.05 10.93 268 73885 6788 42540394
Psoriatic arthropathy 325.56 10.93 301 73852 24666 42522516
Arthralgia 274.49 10.93 882 73271 204356 42342826
Drug hypersensitivity 272.00 10.93 560 73593 98829 42448353
Pain 202.97 10.93 903 73250 243945 42303237
Nightmare 165.82 10.93 211 73942 24801 42522381
Musculoskeletal stiffness 154.94 10.93 323 73830 57442 42489740
Osteoarthritis 152.58 10.93 200 73953 24205 42522977
Nephrolithiasis 141.22 10.93 240 73913 36590 42510592
Sedation 137.79 10.93 214 73939 30261 42516921
Death 133.95 10.93 400 73753 470785 42076397
Neck pain 127.73 10.93 205 73948 29809 42517373
Rheumatoid arthritis 127.73 10.93 249 73904 42191 42504991
Toxicity to various agents 126.88 10.93 127 74026 229009 42318173
Hyperhidrosis 126.11 10.93 395 73758 90117 42457065
Arthritis 125.62 10.93 246 73907 41819 42505363
Back pain 118.76 10.93 525 73628 141251 42405931
Psoriasis 114.56 10.93 258 73895 48346 42498836
Myocardial infarction 102.15 10.93 457 73696 123552 42423630
Juvenile idiopathic arthritis 83.71 10.93 54 74099 2585 42544597
Arthropathy 83.43 10.93 169 73984 29428 42517754
Synovitis 82.81 10.93 118 74035 15449 42531733
Sacroiliitis 81.86 10.93 48 74105 1934 42545248
Drug ineffective 81.65 10.93 1542 72611 628655 41918527
Joint swelling 81.39 10.93 282 73871 67740 42479442
Victim of child abuse 77.61 10.93 39 74114 1150 42546032
Acute kidney injury 75.93 10.93 355 73798 366982 42180200
Epidural lipomatosis 75.42 10.93 44 74109 1756 42545426
Febrile neutropenia 73.18 10.93 132 74021 185571 42361611
Neutropenia 70.61 10.93 151 74002 199280 42347902
Brain scan abnormal 70.35 10.93 37 74116 1202 42545980
Drug dependence 69.16 10.93 155 73998 28939 42518243
Child abuse 66.40 10.93 32 74121 860 42546322
Cerebral artery thrombosis 64.45 10.93 35 74118 1214 42545968
Knee arthroplasty 62.85 10.93 77 74076 8704 42538478
Nasopharyngitis 62.79 10.93 301 73852 83695 42463487
Drug interaction 61.84 10.93 247 73906 266752 42280430
Thrombocytopenia 57.88 10.93 156 73997 190123 42357059
Hypotension 54.91 10.93 246 73907 257385 42289797
Mobility decreased 54.67 10.93 160 73993 35146 42512036
Intervertebral disc protrusion 54.63 10.93 81 74072 10991 42536191
Fibromyalgia 54.53 10.93 49 74104 3864 42543318
Tenderness 54.27 10.93 72 74081 8811 42538371
Multiple organ dysfunction syndrome 53.36 10.93 54 74099 96981 42450201
Axial spondyloarthritis 51.29 10.93 23 74130 522 42546660
Mycobacterium tuberculosis complex test positive 50.13 10.93 32 74121 1504 42545678
Respiratory depression 47.64 10.93 103 74050 18765 42528417
Product prescribing error 46.99 10.93 125 74028 25987 42521195
Product used for unknown indication 46.76 10.93 28 74125 1173 42546009
Pain in extremity 46.22 10.93 432 73721 150172 42397010
Sepsis 45.10 10.93 186 73967 199148 42348034
General physical health deterioration 44.48 10.93 126 74027 151120 42396062
Anxiety 43.62 10.93 354 73799 118206 42428976
Gait disturbance 43.59 10.93 306 73847 97694 42449488
Coronary artery disease 43.43 10.93 197 73956 53523 42493659
Heart rate decreased 42.41 10.93 150 74003 36382 42510800
Chronic idiopathic pain syndrome 41.83 10.93 14 74139 138 42547044
Depressive symptom 41.78 10.93 42 74111 3811 42543371
Pancytopenia 41.75 10.93 89 74064 117654 42429528
Joint range of motion decreased 41.57 10.93 59 74094 7694 42539488
Completed suicide 41.25 10.93 65 74088 96400 42450782
Enthesopathy 40.63 10.93 46 74107 4782 42542400
Foetal exposure during pregnancy 38.53 10.93 17 74136 47294 42499888
Hernia 38.31 10.93 69 74084 11004 42536178
HLA marker study positive 37.74 10.93 14 74139 191 42546991
Drug abuse 37.30 10.93 79 74074 104692 42442490
Anaemia 36.97 10.93 311 73842 279967 42267215
Body temperature decreased 36.75 10.93 79 74074 14334 42532848
Therapeutic product effect decreased 36.58 10.93 150 74003 39000 42508182
Intervertebral disc degeneration 36.49 10.93 54 74099 7313 42539869
Uveitis 36.35 10.93 61 74092 9197 42537985
Leukopenia 36.29 10.93 46 74107 74700 42472482
Red blood cell sedimentation rate increased 35.83 10.93 63 74090 9861 42537321
Cardiogenic shock 35.66 10.93 9 74144 35631 42511551
Muscle swelling 35.61 10.93 17 74136 447 42546735
Pleural thickening 34.50 10.93 17 74136 480 42546702
Blood pressure fluctuation 33.42 10.93 113 74040 26795 42520387
Exostosis 33.41 10.93 45 74108 5586 42541596
Therapeutic product effect incomplete 33.00 10.93 224 73929 70715 42476467
Road traffic accident 32.94 10.93 90 74063 19003 42528179
Depression 32.92 10.93 317 73836 111046 42436136
Diverticulitis intestinal perforated 32.75 10.93 14 74139 282 42546900
Septic shock 32.73 10.93 69 74084 91603 42455579
Intentional overdose 32.66 10.93 25 74128 51431 42495751
Cytomegalovirus infection 32.63 10.93 8 74145 32298 42514884
Spinal pain 32.57 10.93 49 74104 6733 42540449
Spondyloarthropathy 32.23 10.93 20 74133 894 42546288
Hypoaesthesia 31.68 10.93 223 73930 71240 42475942
Depression suicidal 30.92 10.93 33 74120 3212 42543970
Cytokine release syndrome 30.41 10.93 20 74133 44507 42502675
Areflexia 30.38 10.93 35 74118 3708 42543474
Paranoia 30.32 10.93 72 74081 13954 42533228
Bradycardia 29.97 10.93 65 74088 85419 42461763
Grip strength decreased 29.88 10.93 34 74119 3554 42543628
Transposition of the great vessels 29.61 10.93 15 74138 450 42546732
Coma 29.20 10.93 30 74123 53524 42493658
Hypomagnesaemia 28.87 10.93 7 74146 28481 42518701
Diarrhoea 28.41 10.93 599 73554 460250 42086932
Nausea 28.26 10.93 896 73257 395903 42151279
Oesophageal fibrosis 28.11 10.93 11 74142 175 42547007
Cardio-respiratory arrest 27.52 10.93 37 74116 58599 42488583
Inflammation 27.25 10.93 124 74029 33723 42513459
Hip arthroplasty 26.44 10.93 39 74114 5266 42541916
Gingival ulceration 26.33 10.93 14 74139 465 42546717
Oesophagogastric fundoplasty 26.27 10.93 6 74147 10 42547172
Musculoskeletal pain 26.00 10.93 121 74032 33219 42513963
Product use issue 25.98 10.93 225 73928 76526 42470656
Electrocardiogram QT prolonged 25.98 10.93 27 74126 47918 42499264
Hypoglycaemia 25.89 10.93 40 74113 59814 42487368
Blood pressure increased 25.76 10.93 281 73872 101647 42445535
Hypokalaemia 25.59 10.93 54 74099 71667 42475515
Tearfulness 25.54 10.93 31 74122 3469 42543713
Bone marrow oedema 25.51 10.93 17 74136 860 42546322
Xyphoid retraction 25.33 10.93 10 74143 163 42547019
Confusional state 25.33 10.93 179 73974 167418 42379764
Cardiac arrest 25.32 10.93 101 74052 109219 42437963
C-reactive protein increased 25.12 10.93 193 73960 63367 42483815
Lactic acidosis 25.08 10.93 25 74128 45236 42501946
Emotional distress 24.97 10.93 73 74080 16020 42531162
Spinal osteoarthritis 24.95 10.93 50 74103 8636 42538546
Premature baby 24.86 10.93 5 74148 23148 42524034
Off label use 24.76 10.93 886 73267 637449 41909733
Pregnancy of partner 24.72 10.93 13 74140 422 42546760
Rheumatoid lung 24.70 10.93 17 74136 907 42546275
Coronary artery occlusion 24.37 10.93 57 74096 10940 42536242
Inflammatory pain 23.94 10.93 14 74139 561 42546621
Drug resistance 23.91 10.93 15 74138 34233 42512949
Drug tolerance 23.78 10.93 29 74124 3261 42543921
Synovial cyst 23.76 10.93 26 74127 2603 42544579
Foot deformity 23.47 10.93 36 74117 5032 42542150
Hospitalisation 23.28 10.93 60 74093 74270 42472912
Coronary artery stenosis 23.22 10.93 54 74099 10325 42536857
Cystitis bacterial 23.19 10.93 10 74143 206 42546976
Thermal burn 22.93 10.93 27 74126 2927 42544255
Nasal turbinate abnormality 22.78 10.93 7 74146 51 42547131
Rotator cuff syndrome 22.73 10.93 41 74112 6545 42540637
Periarthritis 22.71 10.93 19 74134 1361 42545821
Syndesmophyte 22.30 10.93 10 74143 227 42546955
Iritis 22.28 10.93 21 74132 1761 42545421
Generalised tonic-clonic seizure 22.24 10.93 9 74144 26370 42520812
Lower respiratory tract congestion 22.23 10.93 20 74133 1580 42545602
Hemiplegia 22.21 10.93 45 74108 7834 42539348
Small intestine ulcer 21.96 10.93 13 74140 533 42546649
Dysstasia 21.95 10.93 64 74089 14022 42533160
Spinal disorder 21.81 10.93 33 74120 4558 42542624
Myelosuppression 21.68 10.93 23 74130 40438 42506744
Osteopenia 21.56 10.93 39 74114 6239 42540943
Platelet count decreased 21.43 10.93 147 74006 138434 42408748
Gastrointestinal adenocarcinoma 21.29 10.93 7 74146 65 42547117
Chest pain 21.26 10.93 351 73802 139179 42408003
Psychiatric decompensation 20.99 10.93 31 74122 4191 42542991
Angina unstable 20.79 10.93 55 74098 11393 42535789
Rhabdomyolysis 20.77 10.93 68 74085 77951 42469231
Herpes zoster 20.67 10.93 127 74026 38750 42508432
Pyrexia 20.65 10.93 525 73628 393517 42153665
Sciatica 20.63 10.93 42 74111 7335 42539847
Interstitial lung disease 20.60 10.93 218 73935 78244 42468938
Degenerative bone disease 20.57 10.93 7 74146 73 42547109
Agranulocytosis 20.56 10.93 14 74139 30598 42516584
Knee operation 20.52 10.93 24 74129 2584 42544598
Insomnia 20.49 10.93 304 73849 117949 42429233
Bursitis 20.45 10.93 38 74115 6206 42540976
Diaphragmatic injury 20.40 10.93 8 74145 128 42547054
Obesity 20.33 10.93 69 74084 16390 42530792
Hyponatraemia 20.31 10.93 99 74054 101363 42445819
Arachnoiditis 20.22 10.93 11 74142 383 42546799
Mass 20.14 10.93 46 74107 8693 42538489
Back disorder 20.10 10.93 42 74111 7472 42539710
Splenic embolism 20.08 10.93 10 74143 289 42546893
Ascites 19.94 10.93 43 74110 56635 42490547
Investigation abnormal 19.80 10.93 13 74140 641 42546541
Spinal stenosis 19.76 10.93 38 74115 6368 42540814
Cerebrovascular accident 19.76 10.93 257 73896 96903 42450279
Suicide attempt 19.75 10.93 31 74122 46069 42501113
Gastric ulcer haemorrhage 19.71 10.93 37 74116 6090 42541092
Mucosal inflammation 19.49 10.93 35 74118 49339 42497843
Chest expansion decreased 19.49 10.93 8 74145 145 42547037
Dyspepsia 19.48 10.93 131 74022 41221 42505961
Benign abdominal neoplasm 19.32 10.93 7 74146 89 42547093
Agitation 19.31 10.93 53 74100 64261 42482921
Nerve compression 19.20 10.93 29 74124 3999 42543183
Rib fracture 19.19 10.93 68 74085 16503 42530679
Granuloma 19.13 10.93 29 74124 4012 42543170
Loss of personal independence in daily activities 18.98 10.93 150 74003 49666 42497516
Bronchial wall thickening 18.89 10.93 17 74136 1343 42545839
Abdominal discomfort 18.79 10.93 207 73946 75048 42472134
Ligament rupture 18.68 10.93 17 74136 1363 42545819
Neuroleptic malignant syndrome 18.64 10.93 7 74146 21465 42525717
Seizure 18.58 10.93 128 74025 120433 42426749
Blood pressure systolic abnormal 18.56 10.93 34 74119 5494 42541688
Facial paralysis 18.55 10.93 56 74097 12507 42534675
Carpal tunnel syndrome 18.51 10.93 34 74119 5505 42541677
Salmonella bacteraemia 18.39 10.93 11 74142 460 42546722
Sideroblastic anaemia 18.15 10.93 10 74143 357 42546825
Inadequate analgesia 18.14 10.93 25 74128 3172 42544010
Tumour lysis syndrome 18.08 10.93 8 74145 22223 42524959
Tachycardia 17.80 10.93 103 74050 100984 42446198
Hypervolaemia 17.76 10.93 9 74144 23116 42524066
Ankle fracture 17.71 10.93 31 74122 4835 42542347
Metabolic acidosis 17.70 10.93 40 74113 51818 42495364
Vitamin B1 decreased 17.66 10.93 10 74143 377 42546805
Drug level increased 17.58 10.93 12 74141 26188 42520994
Lumbar spinal stenosis 17.57 10.93 24 74129 3019 42544163
Status epilepticus 17.50 10.93 3 74150 15575 42531607
Haemophagocytic lymphohistiocytosis 17.47 10.93 5 74148 18217 42528965
Hyperbilirubinaemia 17.46 10.93 7 74146 20628 42526554
Neuropathy peripheral 17.29 10.93 105 74048 101748 42445434
Blood pressure diastolic abnormal 17.27 10.93 35 74118 6093 42541089
Hepatic cirrhosis 17.24 10.93 74 74079 19628 42527554
Dactylitis 17.21 10.93 15 74138 1136 42546046
Nasal turbinate hypertrophy 17.17 10.93 8 74145 199 42546983
Hypoxia 17.11 10.93 63 74090 69723 42477459
Adenocarcinoma of appendix 17.05 10.93 7 74146 127 42547055
Tendon disorder 17.01 10.93 25 74128 3364 42543818
Mitral valve incompetence 16.86 10.93 65 74088 16424 42530758
Drug eruption 16.72 10.93 82 74071 22993 42524189
Cardiac failure 16.69 10.93 113 74040 106743 42440439
Chest injury 16.43 10.93 18 74135 1804 42545378
Pelvic pain 16.33 10.93 24 74129 3230 42543952
Drug abuser 16.23 10.93 25 74128 3506 42543676
Cholestasis 16.20 10.93 20 74133 32859 42514323
Overdose 16.10 10.93 112 74041 105152 42442030
Disease progression 16.05 10.93 166 73987 143490 42403692
Injury 15.96 10.93 79 74074 22237 42524945
Drug withdrawal syndrome 15.92 10.93 77 74076 21472 42525710
Nasal septum deviation 15.86 10.93 15 74138 1263 42545919
Foot fracture 15.86 10.93 34 74119 6157 42541025
Diverticulitis 15.85 10.93 80 74073 22693 42524489
Aspergillus infection 15.84 10.93 4 74149 15833 42531349
Oesophageal infection 15.83 10.93 9 74144 342 42546840
Fracture 15.82 10.93 40 74113 8063 42539119
Hyperkalaemia 15.81 10.93 79 74074 80379 42466803
Acute hepatic failure 15.80 10.93 5 74148 17068 42530114
Multiple injuries 15.80 10.93 18 74135 1884 42545298
Energy increased 15.74 10.93 16 74137 1471 42545711
Gastric ulcer 15.52 10.93 68 74085 18194 42528988
Intervertebral disc disorder 15.25 10.93 18 74135 1956 42545226
Gastritis 15.20 10.93 82 74071 23865 42523317
Sinusitis 15.15 10.93 137 74016 47155 42500027
Post procedural infection 15.08 10.93 32 74121 5753 42541429
Psychomotor skills impaired 15.00 10.93 30 74123 5174 42542008
Lid sulcus deepened 14.92 10.93 6 74147 103 42547079
Inflammatory bowel disease 14.86 10.93 24 74129 3505 42543677
Musculoskeletal discomfort 14.71 10.93 43 74110 9433 42537749
Hepatic cytolysis 14.67 10.93 15 74138 26829 42520353
Spinal compression fracture 14.67 10.93 37 74116 7446 42539736
Blood pressure systolic increased 14.64 10.93 91 74062 27877 42519305
Renal failure 14.50 10.93 170 73983 143556 42403626
Myalgia intercostal 14.46 10.93 4 74149 19 42547163
Granulomatous liver disease 14.39 10.93 11 74142 692 42546490
Bronchopulmonary aspergillosis 14.28 10.93 8 74145 19421 42527761
Musculoskeletal disorder 14.27 10.93 34 74119 6604 42540578
Joint space narrowing 14.16 10.93 7 74146 199 42546983
Epistaxis 14.08 10.93 64 74089 66762 42480420
Chronic tonsillitis 13.99 10.93 3 74150 3 42547179
Marrow hyperplasia 13.90 10.93 14 74139 1273 42545909
Gastrointestinal haemorrhage 13.84 10.93 243 73910 97483 42449699
Post procedural fistula 13.72 10.93 6 74147 128 42547054
Hyperglycaemia 13.61 10.93 38 74115 45821 42501361
Tendonitis 13.58 10.93 43 74110 9851 42537331
Movement disorder 13.47 10.93 56 74097 14642 42532540
End stage renal disease 13.40 10.93 6 74147 16552 42530630
Hyperaesthesia 13.35 10.93 31 74122 5921 42541261
Intermittent claudication 13.28 10.93 19 74134 2496 42544686
Facet joint syndrome 13.21 10.93 8 74145 342 42546840
Vascular pseudoaneurysm ruptured 13.18 10.93 9 74144 474 42546708
Medulloblastoma 13.11 10.93 5 74148 74 42547108
Sleep disorder due to a general medical condition 13.10 10.93 7 74146 17446 42529736
Candida infection 13.08 10.93 11 74142 21599 42525583
Duodenal ulcer 13.05 10.93 49 74104 12230 42534952
Joint stiffness 12.95 10.93 49 74104 12273 42534909
Orchitis noninfective 12.92 10.93 4 74149 30 42547152
Myasthenia gravis 12.82 10.93 6 74147 16131 42531051
Hepatitis chronic persistent 12.78 10.93 3 74150 6 42547176
Peptic ulcer 12.76 10.93 22 74131 3390 42543792
Laryngeal pain 12.67 10.93 19 74134 2603 42544579
Clostridium difficile colitis 12.64 10.93 11 74142 21241 42525941
Myocardial oedema 12.63 10.93 7 74146 253 42546929
No adverse event 12.60 10.93 31 74122 38990 42508192
Therapy non-responder 12.54 10.93 49 74104 53310 42493872
Serotonin syndrome 12.44 10.93 16 74137 25829 42521353
Vomiting 12.35 10.93 397 73756 289326 42257856
Feeling abnormal 12.31 10.93 180 73973 69606 42477576
Open angle glaucoma 12.28 10.93 7 74146 267 42546915
Nephropathy toxic 12.28 10.93 7 74146 16831 42530351
Hypophosphataemia 12.27 10.93 11 74142 20934 42526248
Arthritis infective 12.23 10.93 24 74129 4082 42543100
Xerophthalmia 12.22 10.93 6 74147 168 42547014
Accidental overdose 12.18 10.93 19 74134 28311 42518871
Dyspnoea 12.16 10.93 638 73515 441983 42105199
HLA-B*27 positive 12.08 10.93 4 74149 38 42547144
Nervousness 11.97 10.93 51 74102 13481 42533701
Blood creatinine increased 11.92 10.93 128 74025 109875 42437307
Hypogammaglobulinaemia 11.90 10.93 3 74150 11888 42535294
Carotid artery stenosis 11.85 10.93 28 74125 5408 42541774
Blood bilirubin increased 11.82 10.93 36 74117 42216 42504966
Orthostatic hypotension 11.77 10.93 22 74131 30548 42516634
Plasma cell myeloma 11.63 10.93 43 74110 47535 42499647
Blood cholesterol increased 11.58 10.93 83 74070 26658 42520524
Sarcoidosis 11.55 10.93 22 74131 3660 42543522
Intentional self-injury 11.55 10.93 6 74147 15196 42531986
Ankle operation 11.50 10.93 7 74146 302 42546880
Arthritis bacterial 11.49 10.93 29 74124 5839 42541343
Anger 11.47 10.93 49 74104 12969 42534213
Haemarthrosis 11.46 10.93 23 74130 3975 42543207
Rebound psychosis 11.35 10.93 6 74147 197 42546985
Multiple sclerosis 11.34 10.93 34 74119 7564 42539618
Ventricular fibrillation 11.32 10.93 22 74131 30101 42517081
Osteomyelitis 11.29 10.93 62 74091 18161 42529021
Somnolence 11.29 10.93 175 73978 140930 42406252
Psychotic disorder 11.27 10.93 21 74132 29187 42517995
Cerebrospinal fluid retention 11.26 10.93 3 74150 12 42547170
Radiculopathy 11.24 10.93 20 74133 3160 42544022
Dry throat 11.23 10.93 19 74134 2883 42544299
Intestinal resection 11.22 10.93 15 74138 1849 42545333
Upper-airway cough syndrome 11.21 10.93 24 74129 4342 42542840
Nerve block 11.17 10.93 4 74149 49 42547133
Cognitive disorder 11.15 10.93 27 74126 34145 42513037
Tenosynovitis 11.14 10.93 25 74128 4670 42542512
Adverse drug reaction 11.12 10.93 31 74122 37403 42509779
Extranodal marginal zone B-cell lymphoma (MALT type) 11.12 10.93 7 74146 321 42546861
Lymph node palpable 11.10 10.93 4 74149 50 42547132
Neurotoxicity 11.02 10.93 15 74138 23636 42523546
Acute respiratory failure 10.95 10.93 33 74120 38825 42508357

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1580.97 10.46 4387 394749 449703 109740460
Rheumatoid arthritis 1007.97 10.46 2861 396275 296752 109893411
Psoriatic arthropathy 920.09 10.46 2128 397008 194633 109995530
Toxicity to various agents 813.90 10.46 358 398778 480197 109709966
Fibromyalgia 800.66 10.46 1850 397286 169059 110021104
Musculoskeletal stiffness 701.11 10.46 2413 396723 277409 109912754
Death 691.97 10.46 906 398230 697963 109492200
Ankylosing spondylitis 678.91 10.46 514 398622 15098 110175065
Acute kidney injury 677.21 10.46 778 398358 634652 109555511
Arthralgia 568.94 10.46 4775 394361 774857 109415306
Mobility decreased 562.24 10.46 2010 397126 235412 109954751
Arthropathy 555.16 10.46 2281 396855 285241 109904922
Neutropenia 553.76 10.46 333 398803 374287 109815876
Febrile neutropenia 539.11 10.46 234 398902 316533 109873630
Therapeutic product effect decreased 504.13 10.46 1979 397157 242337 109947826
Facet joint syndrome 502.33 10.46 1092 398044 95736 110094427
Anaemia 488.85 10.46 762 398374 546324 109643839
Rheumatic fever 486.36 10.46 1245 397891 121334 110068829
Joint range of motion decreased 475.73 10.46 1230 397906 120602 110069561
Joint swelling 473.44 10.46 2974 396162 439871 109750292
C-reactive protein abnormal 469.50 10.46 1273 397863 128422 110061741
Synovitis 466.29 10.46 2093 397043 271999 109918164
Type 2 diabetes mellitus 459.02 10.46 1546 397590 175686 110014477
Osteoarthritis 456.29 10.46 1574 397562 181049 110009114
Completed suicide 443.63 10.46 160 398976 242221 109947942
Inflammation 442.96 10.46 1619 397517 191619 109998544
Hypotension 437.81 10.46 762 398374 523087 109667076
Lip dry 411.05 10.46 1030 398106 99053 110091110
Bursitis 408.56 10.46 1212 397924 128706 110061457
Contraindicated product administered 407.45 10.46 1876 397260 246391 109943772
Thrombocytopenia 401.41 10.46 400 398736 348485 109841678
Hypoaesthesia 399.31 10.46 2209 396927 312014 109878149
Duodenal ulcer perforation 395.66 10.46 1475 397661 176225 110013938
Breast cancer stage III 391.95 10.46 876 398260 78241 110111922
Folliculitis 389.57 10.46 1411 397725 166242 110023921
Sciatica 372.21 10.46 944 398192 91455 110098708
Drug abuse 370.19 10.46 92 399044 177319 110012844
Impaired healing 364.04 10.46 1541 397595 195176 109994987
Swollen joint count increased 360.47 10.46 877 398259 82784 110107379
Hand deformity 359.13 10.46 1652 397484 216854 109973309
Blood cholesterol increased 351.65 10.46 1460 397676 183325 110006838
Gait inability 348.07 10.46 1184 397952 135192 110054971
Helicobacter infection 339.04 10.46 1428 397708 180449 110009714
Drug intolerance 336.55 10.46 2565 396571 403947 109786216
Sepsis 333.01 10.46 415 398721 326931 109863232
Musculoskeletal pain 328.04 10.46 1420 397716 181603 110008560
Drug interaction 326.86 10.46 836 398300 499347 109690816
Grip strength decreased 320.73 10.46 817 398319 79357 110110806
Injury 313.62 10.46 1370 397766 175895 110014268
Liver injury 312.95 10.46 1222 397914 149191 110040972
Deep vein thrombosis postoperative 312.39 10.46 673 398463 58618 110131545
Glossodynia 308.59 10.46 1600 397536 220404 109969759
Hyponatraemia 306.93 10.46 204 398932 217449 109972714
C-reactive protein increased 302.51 10.46 1570 397566 216349 109973814
Lower limb fracture 299.51 10.46 766 398370 74582 110115581
Intentional overdose 295.98 10.46 59 399077 132442 110057721
Road traffic accident 291.43 10.46 952 398184 106446 110083717
Pancytopenia 284.24 10.46 205 398931 209408 109980755
Autoimmune disorder 281.60 10.46 686 398450 64797 110125366
Irritable bowel syndrome 274.53 10.46 1248 397888 162967 110027196
Dry mouth 271.62 10.46 1432 397704 198516 109991647
Ill-defined disorder 271.18 10.46 1204 397932 155649 110034514
Blepharospasm 269.04 10.46 605 398531 54246 110135917
Wound infection 263.45 10.46 857 398279 95608 110094555
Rheumatoid factor positive 262.16 10.46 1055 398081 130585 110059578
Systemic lupus erythematosus 249.25 10.46 1672 397464 252666 109937497
Multiple organ dysfunction syndrome 247.15 10.46 119 399017 151591 110038572
Live birth 245.34 10.46 676 398460 68808 110121355
Swelling 244.43 10.46 2130 397006 348911 109841252
Muscle injury 243.52 10.46 1081 398055 139726 110050437
Sleep disorder 242.49 10.46 1382 397754 197262 109992901
Obesity 242.35 10.46 929 398207 112422 110077741
Disease progression 242.28 10.46 315 398821 243719 109946444
Cardiac arrest 240.95 10.46 213 398923 196540 109993623
Seizure 234.87 10.46 271 398865 220914 109969249
Foot deformity 233.61 10.46 531 398605 47949 110142214
Pain 227.56 10.46 4766 394370 950189 109239974
Peripheral venous disease 224.93 10.46 742 398394 83375 110106788
Electrocardiogram QT prolonged 224.38 10.46 58 399078 108902 110081261
Neck pain 223.37 10.46 959 398177 122171 110067992
Liver disorder 217.20 10.46 1053 398083 141190 110048973
Treatment failure 215.75 10.46 1725 397411 275509 109914654
Pain in extremity 214.13 10.46 2692 396444 484426 109705737
Somnolence 210.86 10.46 476 398660 296973 109893190
Rheumatoid nodule 207.67 10.46 308 398828 19988 110170175
Hypercholesterolaemia 207.07 10.46 760 398376 90077 110100086
Pemphigus 203.28 10.46 1399 397737 213171 109976992
Anti-cyclic citrullinated peptide antibody positive 200.78 10.46 1233 397903 180751 110009412
Dyspnoea 200.51 10.46 2803 396333 1104069 109086094
Arthritis 198.02 10.46 1156 397980 166430 110023733
Bradycardia 196.94 10.46 163 398973 155354 110034809
Hepatic enzyme increased 196.92 10.46 1895 397241 318997 109871166
Night sweats 196.82 10.46 981 398155 133002 110057161
Constipation 193.58 10.46 653 398483 357133 109833030
Wound 190.24 10.46 1473 397663 232964 109957199
C-reactive protein 188.94 10.46 369 398767 29962 110160201
Myelosuppression 187.16 10.46 54 399082 94286 110095877
Therapeutic product effect incomplete 186.51 10.46 1415 397721 222390 109967773
Hypoglycaemia 184.67 10.46 94 399042 116010 110074153
Peripheral swelling 181.39 10.46 2242 396894 401792 109788371
Dehydration 180.95 10.46 469 398667 279042 109911121
Suicide attempt 179.55 10.46 74 399062 103320 110086843
Respiratory failure 177.06 10.46 316 398820 215016 109975147
Urticaria 176.81 10.46 1844 397292 317013 109873150
Abdominal discomfort 176.57 10.46 2185 396951 391673 109798490
Nail disorder 174.97 10.46 533 398603 57402 110132761
Drug tolerance 173.03 10.46 254 398882 16331 110173832
Onychomadesis 169.95 10.46 453 398683 45210 110144953
Mucosal inflammation 169.90 10.46 67 399069 96074 110094089
Neuropathy peripheral 167.25 10.46 242 398894 179035 110011128
Platelet count decreased 167.20 10.46 364 398772 230079 109960084
Red blood cell sedimentation rate increased 166.73 10.46 641 398495 77661 110112502
Migraine 166.01 10.46 1125 398011 170527 110019636
Sleep disorder due to general medical condition, insomnia type 164.82 10.46 787 398349 104856 110085307
Tachycardia 163.61 10.46 359 398777 226286 109963877
Back injury 161.26 10.46 455 398681 46944 110143219
Blister 160.91 10.46 1385 397751 225991 109964172
Hypoxia 160.00 10.46 139 398997 129376 110060787
Cytokine release syndrome 157.64 10.46 31 399105 70275 110119888
Lung disorder 157.15 10.46 1151 397985 178896 110011267
Syncope 157.01 10.46 308 398828 202228 109987935
Pyrexia 156.00 10.46 2293 396843 895972 109294191
Nasopharyngitis 155.46 10.46 2137 396999 392224 109797939
Prescribed overdose 153.36 10.46 675 398461 86906 110103257
Gastrointestinal disorder 151.91 10.46 1436 397700 240516 109949647
Stomatitis 151.26 10.46 1566 397570 268676 109921487
Pericarditis 150.01 10.46 1325 397811 217789 109972374
Finger deformity 147.97 10.46 352 398784 32740 110157423
Cardio-respiratory arrest 147.16 10.46 121 399015 115715 110074448
Dislocation of vertebra 147.09 10.46 418 398718 43303 110146860
Hypertension 146.99 10.46 2622 396514 507462 109682701
Pulmonary fibrosis 143.43 10.46 738 398398 101304 110088859
Leukopenia 142.60 10.46 197 398939 148594 110041569
Taste disorder 140.63 10.46 537 398599 64850 110125313
Off label use 140.47 10.46 4236 394900 1495949 108694214
Adjustment disorder with depressed mood 138.43 10.46 410 398726 43473 110146690
Septic shock 136.99 10.46 223 398913 157305 110032858
Abdominal pain upper 136.83 10.46 1890 397246 347221 109842942
Tremor 134.98 10.46 334 398802 201898 109988265
Metabolic acidosis 133.27 10.46 99 399037 99645 110090518
Encephalopathy 132.87 10.46 63 399073 80992 110109171
Loss of personal independence in daily activities 132.60 10.46 962 398174 149058 110041105
Drug tolerance decreased 131.95 10.46 301 398835 27239 110162924
Hyperkalaemia 131.95 10.46 178 398958 135618 110054545
Pulmonary embolism 131.90 10.46 369 398767 214105 109976058
Drug ineffective 129.89 10.46 6715 392421 1513825 108676338
Renal failure 129.79 10.46 403 398733 226171 109963992
Cardiogenic shock 129.15 10.46 25 399111 57313 110132850
Overdose 127.55 10.46 425 398711 233369 109956794
Cardiac failure 126.69 10.46 308 398828 187318 110002845
Cytomegalovirus infection 126.37 10.46 22 399114 54422 110135741
Product label confusion 125.89 10.46 263 398873 22414 110167749
Alopecia 124.15 10.46 1927 397209 362826 109827337
Neutrophil count decreased 123.20 10.46 153 398983 120788 110069375
Infusion related reaction 123.07 10.46 1996 397140 379166 109810997
Hypokalaemia 122.80 10.46 300 398836 182148 110008015
Wheezing 119.51 10.46 1428 397708 253802 109936361
Rhabdomyolysis 118.83 10.46 156 398980 120245 110069918
COVID-19 118.79 10.46 468 398668 244592 109945571
Product dose omission issue 118.76 10.46 678 398458 321104 109869059
Red blood cell sedimentation rate abnormal 117.57 10.46 268 398868 24241 110165922
Epistaxis 116.72 10.46 181 398955 130191 110059972
Condition aggravated 116.22 10.46 3472 395664 731364 109458799
Drug resistance 116.07 10.46 30 399106 56344 110133819
International normalised ratio fluctuation 116.00 10.46 105 399031 3975 110186188
Hepatic cytolysis 115.86 10.46 28 399108 55025 110135138
Cholestasis 113.93 10.46 45 399091 64473 110125690
Hyperglycaemia 112.98 10.46 85 399051 85005 110105158
Onychomycosis 112.17 10.46 350 398786 38181 110151982
Agitation 112.06 10.46 146 398990 112905 110077258
Exostosis 111.09 10.46 392 398744 45564 110144599
Lower respiratory tract infection 110.68 10.46 1353 397783 241753 109948410
Epilepsy 109.86 10.46 678 398458 99531 110090632
Coma 109.04 10.46 160 398976 117709 110072454
Ascites 108.22 10.46 105 399031 92703 110097460
Orthostatic hypotension 106.30 10.46 53 399083 66196 110123967
Malignant neoplasm progression 105.36 10.46 303 398833 174264 110015899
Memory impairment 105.33 10.46 1131 398005 195813 109994350
Sopor 104.37 10.46 7 399129 36539 110153624
White blood cell count decreased 103.74 10.46 450 398686 228940 109961223
Hypersensitivity 102.25 10.46 2036 397100 401962 109788201
Blood parathyroid hormone decreased 101.43 10.46 175 398961 12914 110177249
Cognitive disorder 100.89 10.46 100 399036 87411 110102752
X-ray abnormal 100.77 10.46 335 398801 37782 110152381
Product quality issue 100.37 10.46 547 398589 76752 110113411
Mental status changes 99.84 10.46 77 399059 76045 110114118
Prescribed underdose 99.09 10.46 482 398654 64692 110125471
Intentional self-injury 99.07 10.46 10 399126 37419 110152744
Acute respiratory failure 97.61 10.46 77 399059 75183 110114980
Gastrooesophageal reflux disease 97.38 10.46 1036 398100 178940 110011223
Lactic acidosis 97.08 10.46 115 399021 92696 110097467
Blood bilirubin increased 96.94 10.46 79 399057 75893 110114270
Dysphagia 96.86 10.46 261 398875 153339 110036824
Thyroid neoplasm 95.91 10.46 86 399050 3215 110186948
Bloody discharge 95.24 10.46 79 399057 2654 110187509
Depression 94.05 10.46 1639 397497 315696 109874467
Lupus vulgaris 93.35 10.46 302 398834 33581 110156582
Chills 92.96 10.46 363 398773 190217 109999946
Granuloma skin 92.92 10.46 155 398981 11128 110179035
Clostridium difficile colitis 92.65 10.46 22 399114 43756 110146407
Gait disturbance 92.41 10.46 1464 397672 276744 109913419
Dyspepsia 91.81 10.46 1074 398062 189891 110000272
Nephrolithiasis 91.73 10.46 477 398659 65735 110124428
Knee arthroplasty 91.44 10.46 470 398666 64478 110125685
Weight increased 91.35 10.46 2069 397067 417575 109772588
Depressed level of consciousness 91.15 10.46 166 398970 112112 110078051
Panniculitis 90.36 10.46 184 398952 15398 110174765
Hypervolaemia 89.83 10.46 33 399103 49427 110140736
Psoriasis 88.86 10.46 833 398303 139160 110051003
Colitis 88.81 10.46 145 398991 102178 110087985
Discomfort 87.16 10.46 1170 397966 213537 109976626
Infection 86.87 10.46 1811 397325 360389 109829774
Hip arthroplasty 86.46 10.46 415 398721 55398 110134765
Bone erosion 86.24 10.46 364 398772 46007 110144156
Insomnia 86.18 10.46 1802 397334 358788 109831375
Adverse reaction 85.39 10.46 268 398868 29326 110160837
Eosinophilia 84.77 10.46 52 399084 57884 110132279
Plasma cell myeloma 84.68 10.46 62 399074 62874 110127289
Agranulocytosis 84.19 10.46 60 399076 61700 110128463
Bone swelling 83.72 10.46 62 399074 1759 110188404
Atrial fibrillation 83.54 10.46 486 398650 229156 109961007
Osteoporosis 83.50 10.46 570 398566 86582 110103581
Adverse event 82.88 10.46 674 398462 108135 110082028
Drug ineffective for unapproved indication 82.63 10.46 153 398983 102685 110087478
Poisoning deliberate 81.68 10.46 3 399133 26328 110163835
Dysarthria 80.97 10.46 111 399025 84010 110106153
Pleural thickening 80.41 10.46 79 399057 3320 110186843
Generalised tonic-clonic seizure 80.11 10.46 49 399087 54631 110135532
Device expulsion 79.85 10.46 9 399127 30882 110159281
Sinusitis 79.00 10.46 1507 397629 295181 109894982
Premature delivery 78.99 10.46 9 399127 30623 110159540
Injection site reaction 78.01 10.46 570 398566 88500 110101663
Blood creatinine increased 77.76 10.46 367 398769 182522 110007641
Hepatic failure 77.59 10.46 80 399056 68659 110121504
Disability 77.57 10.46 263 398873 29960 110160203
Pneumonia aspiration 76.38 10.46 109 399027 81124 110109039
Blood glucose increased 76.32 10.46 235 398901 132261 110057902
Ventricular fibrillation 75.99 10.46 27 399109 41286 110148877
Product use issue 75.88 10.46 1562 397574 310133 109880030
Presbyacusis 75.18 10.46 70 399066 2749 110187414
Lyme disease 74.82 10.46 85 399051 4231 110185932
Infusion site reaction 73.62 10.46 183 398953 17499 110172664
Diarrhoea 73.61 10.46 3363 395773 1136142 109054021
Foot fracture 73.39 10.46 231 398905 25315 110164848
Intentional product use issue 73.27 10.46 1280 397856 246626 109943537
Enthesopathy 73.13 10.46 148 398988 12330 110177833
Pulmonary oedema 72.96 10.46 159 398977 100500 110089663
Ulcer haemorrhage 72.25 10.46 212 398924 22359 110167804
Posterior reversible encephalopathy syndrome 71.69 10.46 17 399119 33844 110156319
International normalised ratio increased 71.59 10.46 127 399009 86645 110103518
Diabetic ketoacidosis 71.57 10.46 31 399105 42027 110148136
Fall 71.40 10.46 1646 397490 601836 109588327
Gamma-glutamyltransferase increased 70.74 10.46 70 399066 61239 110128924
Status epilepticus 70.60 10.46 14 399122 31557 110158606
Joint stiffness 70.60 10.46 450 398686 66793 110123370
Psychotic disorder 70.07 10.46 49 399087 50888 110139275
Aspergillus infection 70.05 10.46 6 399130 25610 110164553
Drug reaction with eosinophilia and systemic symptoms 69.70 10.46 118 399018 81977 110108186
Urinary tract infection 69.65 10.46 797 398339 325485 109864678
Hallucination 69.64 10.46 165 398971 101267 110088896
Bronchopulmonary aspergillosis 69.45 10.46 12 399124 29851 110160312
Clostridium difficile infection 69.30 10.46 52 399084 52077 110138086
Drug eruption 69.17 10.46 379 398757 53280 110136883
Aggression 69.01 10.46 67 399069 59143 110131020
Neurotoxicity 68.88 10.46 33 399103 42174 110147989
Neoplasm progression 68.67 10.46 79 399057 64516 110125647
Oedema 67.84 10.46 1100 398036 208876 109981287
Hyperbilirubinaemia 67.76 10.46 14 399122 30657 110159506
Pulmonary arterial hypertension 67.69 10.46 17 399119 32551 110157612
Deformity 67.45 10.46 127 399009 10033 110180130
Pleural effusion 67.38 10.46 371 398765 177338 110012825
Systemic lupus erythematosus rash 67.15 10.46 57 399079 1978 110188185
Loss of employment 65.12 10.46 70 399066 3274 110186889
Acute hepatic failure 65.11 10.46 25 399111 36443 110153720
Poisoning 64.89 10.46 13 399123 29092 110161071
Chest discomfort 64.79 10.46 365 398771 173483 110016680
Bone marrow failure 64.53 10.46 68 399068 57780 110132383
Respiratory arrest 64.50 10.46 69 399067 58230 110131933
Cerebral haemorrhage 64.28 10.46 84 399052 64884 110125279
Ulcer 64.20 10.46 317 398819 42799 110147364
Malaise 64.04 10.46 3001 396135 668818 109521345
Neutropenic sepsis 63.99 10.46 16 399120 30730 110159433
Transplant rejection 63.90 10.46 7 399129 24560 110165603
Ventricular tachycardia 63.80 10.46 52 399084 49957 110140206
Sacroiliitis 63.53 10.46 84 399052 4894 110185269
Blood calcium decreased 63.29 10.46 25 399111 35820 110154343
Thrombotic microangiopathy 62.98 10.46 14 399122 29135 110161028
Pneumonia 62.86 10.46 2557 396579 874157 109316006
Axial spondyloarthritis 62.07 10.46 39 399097 839 110189324
Toxic epidermal necrolysis 61.81 10.46 68 399068 56659 110133504
Pleural fibrosis 61.74 10.46 77 399059 4231 110185932
Right ventricular failure 61.31 10.46 10 399126 25944 110164219
Tachypnoea 61.00 10.46 33 399103 39362 110150801
Pneumonitis 60.48 10.46 115 399021 76416 110113747
Neuroleptic malignant syndrome 59.73 10.46 24 399112 34035 110156128
Drug level increased 59.18 10.46 51 399085 47668 110142495
Hypomagnesaemia 58.76 10.46 79 399057 60291 110129872
Haemoglobin decreased 58.52 10.46 594 398542 248133 109942030
Palmar-plantar erythrodysaesthesia syndrome 58.40 10.46 38 399098 40987 110149176
Hepatocellular injury 58.22 10.46 58 399078 50584 110139579
Progressive multifocal leukoencephalopathy 58.10 10.46 10 399126 24946 110165217
Bacteraemia 58.02 10.46 41 399095 42349 110147814
Intervertebral disc protrusion 57.52 10.46 225 398911 27473 110162690
Pulmonary alveolar haemorrhage 57.13 10.46 4 399132 20146 110170017
Tenosynovitis 57.04 10.46 158 398978 16125 110174038
Gastric disorder 56.80 10.46 255 398881 33102 110157061
Walking aid user 56.45 10.46 209 398927 24866 110165297
Haematuria 56.21 10.46 136 399000 82869 110107294
Brain oedema 56.05 10.46 21 399115 31077 110159086
Liver function test increased 55.73 10.46 526 398610 88022 110102141
Laryngitis 55.64 10.46 301 398835 42110 110148053
Pancreatitis acute 55.56 10.46 82 399054 60192 110129971
Grip strength 55.46 10.46 110 399026 9031 110181132
Lethargy 55.30 10.46 164 398972 93412 110096751
Tumour lysis syndrome 55.18 10.46 21 399115 30780 110159383
Torsade de pointes 55.00 10.46 8 399128 22592 110167571
Transaminases increased 54.84 10.46 90 399046 63300 110126863
Therapy partial responder 54.59 10.46 33 399103 37028 110153135
Pericardial effusion 54.56 10.46 76 399060 57141 110133022
Maternal exposure during pregnancy 54.25 10.46 1253 397883 253630 109936533
Joint destruction 53.98 10.46 121 399015 10822 110179341
Haematochezia 53.82 10.46 224 398912 115300 110074863
Muscle spasms 53.63 10.46 1349 397787 276808 109913355
Dyskinesia 53.53 10.46 64 399072 51382 110138781
Nerve injury 53.45 10.46 119 399017 10594 110179569
Chronic kidney disease 53.26 10.46 123 399013 76168 110113995
Serotonin syndrome 53.05 10.46 82 399054 59071 110131092
Miosis 52.99 10.46 8 399128 21975 110168188
Extrapyramidal disorder 52.86 10.46 19 399117 28848 110161315
Aphasia 52.70 10.46 82 399054 58915 110131248
Porphyria acute 52.29 10.46 168 398968 18612 110171551
Leukocytosis 51.83 10.46 71 399065 53757 110136406
Haemoptysis 51.47 10.46 113 399023 71241 110118922
Device dislocation 51.41 10.46 25 399111 31679 110158484
Mydriasis 51.32 10.46 9 399127 22148 110168015
Therapy non-responder 51.14 10.46 825 398311 156482 110033681
Joint effusion 51.11 10.46 179 398957 20726 110169437
Pulmonary hypertension 51.02 10.46 75 399061 55145 110135018
Disorientation 50.91 10.46 112 399024 70559 110119604
Victim of child abuse 50.73 10.46 39 399097 1172 110188991
Skin necrosis 50.70 10.46 182 398954 21330 110168833
Blood potassium decreased 50.49 10.46 73 399063 54041 110136122
Neoplasm malignant 50.35 10.46 266 398870 36877 110153286
Myelodysplastic syndrome 50.33 10.46 37 399099 37447 110152716
Schizophrenia 50.26 10.46 9 399127 21817 110168346
Pallor 49.95 10.46 79 399057 56388 110133775
Myocarditis 49.81 10.46 23 399113 30032 110160131
Maternal exposure timing unspecified 49.72 10.46 178 398958 20835 110169328
COVID-19 pneumonia 49.44 10.46 37 399099 37106 110153057
Foot operation 49.28 10.46 92 399044 7221 110182942
Accidental overdose 49.27 10.46 69 399067 51765 110138398
Cytomegalovirus viraemia 49.02 10.46 4 399132 17760 110172403
Klebsiella infection 48.89 10.46 7 399129 20002 110170161
Nephropathy toxic 48.79 10.46 19 399117 27459 110162704
Therapeutic response decreased 48.72 10.46 548 398588 95951 110094212
Musculoskeletal disorder 48.61 10.46 186 398950 22478 110167685
Restlessness 48.55 10.46 80 399056 56179 110133984
Abortion spontaneous 48.47 10.46 32 399104 34250 110155913
Sedation complication 48.38 10.46 7 399129 19848 110170315
Dry skin 48.15 10.46 212 398924 107441 110082722
Febrile bone marrow aplasia 48.01 10.46 4 399132 17461 110172702
Lymphocyte count decreased 47.93 10.46 83 399053 57160 110133003
Haematotoxicity 47.88 10.46 9 399127 21073 110169090
Unresponsive to stimuli 47.70 10.46 99 399037 63691 110126472
Acute respiratory distress syndrome 47.46 10.46 74 399062 53124 110137039
Device difficult to use 47.32 10.46 6 399130 18799 110171364
Chronic obstructive pulmonary disease 47.00 10.46 218 398918 108940 110081223
Cytopenia 46.96 10.46 25 399111 30091 110160072
Bedridden 46.76 10.46 130 399006 13295 110176868
Multiple sclerosis relapse 46.65 10.46 68 399068 50172 110139991
Haemophagocytic lymphohistiocytosis 46.62 10.46 28 399108 31531 110158632
Blood magnesium increased 46.47 10.46 63 399073 3760 110186403
Hepatic encephalopathy 46.25 10.46 22 399114 28234 110161929
Pathogen resistance 46.06 10.46 5 399131 17667 110172496
Foetal death 46.03 10.46 3 399133 16042 110174121
Angioedema 45.88 10.46 191 398945 98309 110091854
Therapy interrupted 45.71 10.46 68 399068 49754 110140409
Enterococcal infection 45.61 10.46 9 399127 20357 110169806
Sinus tachycardia 45.60 10.46 56 399080 44437 110145726
Dysstasia 45.24 10.46 237 398899 32749 110157414
Polyneuropathy 45.09 10.46 30 399106 31982 110158181
Hypermobility syndrome 45.01 10.46 27 399109 533 110189630
Balance disorder 44.91 10.46 242 398894 116318 110073845
Female genital tract fistula 44.82 10.46 4 399132 16515 110173648
Child abuse 44.81 10.46 32 399104 857 110189306
Coeliac disease 44.71 10.46 288 398848 42899 110147264
Aplastic anaemia 44.51 10.46 16 399120 24292 110165871
Drug-induced liver injury 43.74 10.46 642 398494 119425 110070738
Full blood count abnormal 43.62 10.46 85 399051 55967 110134196
Respiratory distress 43.43 10.46 117 399019 68757 110121406
Inappropriate antidiuretic hormone secretion 43.43 10.46 35 399101 33816 110156347
Cardiotoxicity 43.43 10.46 5 399131 16876 110173287
Venoocclusive liver disease 43.17 10.46 3 399133 15204 110174959
Delusion 42.88 10.46 16 399120 23739 110166424
Polyarthritis 42.64 10.46 158 398978 18805 110171358
Wrist deformity 42.54 10.46 55 399081 3134 110187029
Ejection fraction decreased 42.38 10.46 51 399085 40829 110149334
Creatinine renal clearance decreased 42.33 10.46 13 399123 21802 110168361
Multiple fractures 42.04 10.46 97 399039 8843 110181320
Haemodynamic instability 42.02 10.46 15 399121 22873 110167290
Blood creatine phosphokinase increased 41.80 10.46 130 399006 72947 110117216
Hyperthyroidism 41.79 10.46 27 399109 29234 110160929
Rash 41.74 10.46 3472 395664 817492 109372671
Immune effector cell-associated neurotoxicity syndrome 41.72 10.46 3 399133 14779 110175384
Parkinsonism 41.67 10.46 14 399122 22173 110167990
Thrombosis 41.65 10.46 226 398910 108436 110081727
Blood phosphorus increased 41.64 10.46 5 399131 16335 110173828
Joint injury 41.58 10.46 267 398869 39727 110150436
Epidural lipomatosis 41.55 10.46 44 399092 2023 110188140
End stage renal disease 41.30 10.46 13 399123 21460 110168703
Device related infection 41.29 10.46 49 399087 39470 110150693
Abnormal behaviour 41.22 10.46 48 399088 38991 110151172
General physical health deterioration 41.14 10.46 1903 397233 423392 109766771
Circulatory collapse 41.10 10.46 57 399079 42936 110147227
Shock 41.06 10.46 82 399054 53506 110136657
Renal tubular necrosis 41.02 10.46 30 399106 30445 110159718
Disturbance in attention 40.86 10.46 103 399033 61892 110128271
Pseudomonas infection 40.75 10.46 25 399111 27828 110162335
Rheumatoid lung 40.74 10.46 63 399073 4241 110185922
Epstein-Barr virus infection 40.48 10.46 9 399127 18729 110171434
Left ventricular dysfunction 40.48 10.46 17 399119 23476 110166687
Ankle arthroplasty 40.47 10.46 48 399088 2503 110187660
Hallucination, visual 40.43 10.46 50 399086 39555 110150608
Obstructive airways disorder 40.41 10.46 65 399071 46084 110144079
Lupus-like syndrome 40.38 10.46 269 398867 40523 110149640
Rotator cuff syndrome 40.36 10.46 143 398993 16651 110173512
Renal impairment 40.31 10.46 460 398676 187985 110002178
Paraesthesia 40.21 10.46 1294 397842 275227 109914936
Skin exfoliation 40.18 10.46 171 398965 87480 110102683
Hepatic enzyme 39.97 10.46 69 399067 5094 110185069
Presyncope 39.92 10.46 72 399064 48815 110141348
Retinitis 39.45 10.46 225 398911 32102 110158061
Paraesthesia oral 39.36 10.46 38 399098 33633 110156530
Blood lactate dehydrogenase increased 39.24 10.46 62 399074 44272 110145891
Proctitis 38.93 10.46 7 399129 16920 110173243
Electrolyte imbalance 38.59 10.46 46 399090 36982 110153181
Heart rate increased 38.32 10.46 333 398803 143501 110046662
Hallucination, auditory 38.19 10.46 24 399112 26373 110163790
Cough 37.96 10.46 1324 397812 460317 109729846
Suicidal ideation 37.89 10.46 192 398944 93745 110096418
Flushing 37.88 10.46 222 398914 104514 110085649
Unevaluable event 37.81 10.46 100 399036 59127 110131036
No adverse event 37.70 10.46 138 398998 73701 110116462
Eczema 37.65 10.46 134 399002 72159 110118004
Vascular device infection 37.61 10.46 7 399129 16505 110173658
Productive cough 37.36 10.46 250 398886 114055 110076108
Neutrophil count increased 37.25 10.46 42 399094 34610 110155553
Loss of consciousness 37.14 10.46 492 398644 195814 109994349
Haemorrhage intracranial 37.11 10.46 30 399106 28939 110161224
Rash maculo-papular 37.06 10.46 140 398996 74082 110116081
Device issue 36.97 10.46 42 399094 34493 110155670
Troponin increased 36.68 10.46 32 399104 29734 110160429
Dystonia 36.60 10.46 24 399112 25781 110164382
Rebound effect 36.60 10.46 5 399131 14801 110175362
Bunion operation 36.56 10.46 29 399107 913 110189250
Infective pulmonary exacerbation of cystic fibrosis 36.48 10.46 5 399131 14766 110175397
Brain scan abnormal 36.21 10.46 36 399100 1535 110188628
Intervertebral disc degeneration 36.02 10.46 145 398991 17940 110172223
Acute myeloid leukaemia 35.96 10.46 51 399085 38059 110152104
Muscle twitching 35.91 10.46 33 399103 29902 110160261
Hypophosphataemia 35.90 10.46 40 399096 33142 110157021
Haemorrhage 35.55 10.46 232 398904 106460 110083703
Burning mouth syndrome 35.45 10.46 25 399111 656 110189507
Tubulointerstitial nephritis 35.15 10.46 91 399045 54193 110135970
Anti-cyclic citrullinated peptide antibody 35.03 10.46 154 398982 19810 110170353
Deep vein thrombosis 35.02 10.46 329 398807 139558 110050605
Impaired work ability 34.99 10.46 188 398948 26231 110163932
Myasthenia gravis 34.82 10.46 17 399119 21494 110168669
Hypoalbuminaemia 34.69 10.46 32 399104 28942 110161221
Intestinal obstruction 34.64 10.46 89 399047 53138 110137025
Myalgia 34.59 10.46 579 398557 221802 109968361
Salivary hypersecretion 34.49 10.46 10 399126 17411 110172752
Depressed mood 34.20 10.46 109 399027 60700 110129463
Malnutrition 34.01 10.46 29 399107 27250 110162913
Muscle spasticity 33.95 10.46 48 399088 35867 110154296
Dyspnoea exertional 33.80 10.46 228 398908 103832 110086331
Dysgeusia 33.66 10.46 134 399002 69851 110120312
Coagulopathy 33.63 10.46 60 399076 40851 110149312
Synovial cyst 33.42 10.46 104 399032 11326 110178837
Blood lactic acid increased 33.38 10.46 8 399128 15813 110174350
Blood alkaline phosphatase increased 33.37 10.46 137 398999 70798 110119365
Swollen joint count 33.23 10.46 87 399049 8587 110181576
Iritis 33.21 10.46 60 399076 4592 110185571
Labelled drug-drug interaction medication error 33.18 10.46 34 399102 29268 110160895
Antinuclear antibody positive 33.15 10.46 90 399046 9078 110181085
Hyperammonaemia 33.10 10.46 5 399131 13727 110176436
Cystitis haemorrhagic 33.01 10.46 3 399133 12206 110177957
Product administration error 32.98 10.46 52 399084 37165 110152998
Osteopenia 32.86 10.46 163 398973 22046 110168117
Amnesia 32.83 10.46 549 398587 104859 110085304
Exposure to toxic agent 32.60 10.46 4 399132 12854 110177309
Juvenile idiopathic arthritis 32.57 10.46 69 399067 5938 110184225
Joint dislocation 32.37 10.46 223 398913 33967 110156196
Epicondylitis 32.36 10.46 43 399093 2517 110187646
Subdural haematoma 32.24 10.46 51 399085 36403 110153760
Tendonitis 32.13 10.46 182 398954 25901 110164262
Gastric ulcer 32.12 10.46 250 398886 39577 110150586
Chronic sinusitis 32.10 10.46 26 399110 25058 110165105
Overlap syndrome 31.83 10.46 88 399048 8971 110181192
Spondyloarthropathy 31.81 10.46 34 399102 1580 110188583
Oxygen saturation decreased 31.72 10.46 388 398748 156594 110033569
Dactylitis 31.69 10.46 55 399081 4078 110186085
Suspected suicide 31.46 10.46 8 399128 15191 110174972
Activated partial thromboplastin time prolonged 31.46 10.46 21 399115 22347 110167816
Drug use disorder 31.27 10.46 13 399123 18061 110172102
Wrong technique in product usage process 31.14 10.46 186 398950 87162 110103001
Hypovolaemia 30.95 10.46 20 399116 21654 110168509
Immune reconstitution inflammatory syndrome 30.89 10.46 10 399126 16216 110173947
Investigation abnormal 30.66 10.46 41 399095 2415 110187748
Transfusion 30.65 10.46 28 399108 25444 110164719
Tenderness 30.28 10.46 196 398940 29241 110160922
Full blood count decreased 30.24 10.46 43 399093 32056 110158107
Glomerular filtration rate decreased 30.15 10.46 36 399100 28920 110161243
Epigastric discomfort 30.13 10.46 86 399050 8929 110181234
Liver function test abnormal 30.10 10.46 137 398999 68813 110121350
Rash erythematous 29.84 10.46 173 398963 81659 110108504
Residual urine volume increased 29.62 10.46 12 399124 95 110190068
Lacrimation increased 29.62 10.46 41 399095 30909 110159254
Pregnancy 29.51 10.46 298 398838 50769 110139394
Hypercapnia 29.49 10.46 3 399133 11156 110179007
Staphylococcal sepsis 29.48 10.46 13 399123 17441 110172722
Fine motor skill dysfunction 29.42 10.46 68 399068 6206 110183957
Atrioventricular block complete 29.41 10.46 18 399118 20064 110170099
Splenomegaly 29.39 10.46 27 399109 24471 110165692
Toothache 29.37 10.46 165 398971 23410 110166753
Hypothermia 29.24 10.46 31 399105 26271 110163892
Bacterial infection 29.18 10.46 78 399058 45958 110144205
Blood folate decreased 29.18 10.46 39 399097 2296 110187867
Cerebral artery thrombosis 29.17 10.46 33 399103 1635 110188528
Normal newborn 29.13 10.46 156 398980 21740 110168423
Blood sodium decreased 29.05 10.46 59 399077 38260 110151903
Hypernatraemia 29.01 10.46 14 399122 17819 110172344
Body height decreased 28.96 10.46 94 399042 10469 110179694
Dermatitis exfoliative generalised 28.86 10.46 3 399133 10969 110179194
Breast cancer stage II 28.61 10.46 183 398953 27192 110162971
Deafness neurosensory 28.57 10.46 88 399048 9531 110180632
Hyperthermia 28.56 10.46 21 399115 21251 110168912
Vulvovaginal swelling 28.47 10.46 21 399115 592 110189571
Myoclonus 28.40 10.46 47 399089 32951 110157212
Skin ulcer 28.40 10.46 353 398783 63292 110126871
Oesophageal spasm 28.39 10.46 49 399087 3617 110186546
Failure to thrive 28.37 10.46 7 399129 13567 110176596
Sinus bradycardia 28.27 10.46 39 399097 29444 110160719
Osteosclerosis 28.20 10.46 55 399081 4460 110185703
Intentional product misuse 28.19 10.46 325 398811 132579 110057584
Jaundice 28.12 10.46 114 399022 59122 110131041
Irritability 28.09 10.46 84 399052 47725 110142438
Fluid retention 28.02 10.46 212 398924 94095 110096068
Urosepsis 28.01 10.46 42 399094 30633 110159530
Cyst 28.00 10.46 126 399010 16370 110173793
Skin haemorrhage 27.89 10.46 29 399107 24798 110165365
Anuria 27.84 10.46 28 399108 24313 110165850
Gastric ulcer haemorrhage 27.83 10.46 90 399046 10004 110180159
Fracture pain 27.75 10.46 27 399109 1121 110189042
Escherichia infection 27.69 10.46 27 399109 23789 110166374
Oedema peripheral 27.60 10.46 940 398196 327720 109862443
Nodule 27.52 10.46 207 398929 32424 110157739
Impaired quality of life 27.50 10.46 41 399095 29976 110160187
Respiratory syncytial virus infection 27.44 10.46 9 399127 14475 110175688
Treatment noncompliance 27.31 10.46 153 398983 72837 110117326
Nasal polyps 27.22 10.46 7 399129 13193 110176970
Alanine aminotransferase increased 27.12 10.46 483 398653 183290 110006873
Vulvovaginal erythema 26.96 10.46 19 399117 498 110189665
Injection site erythema 26.91 10.46 214 398922 93962 110096201
Cyanosis 26.89 10.46 41 399095 29700 110160463
Hypogammaglobulinaemia 26.72 10.46 20 399116 20056 110170107
Atrioventricular block first degree 26.67 10.46 9 399127 14216 110175947
Asphyxia 26.64 10.46 9 399127 14206 110175957
Hemiparesis 26.62 10.46 76 399060 43827 110146336
Jaw clicking 26.53 10.46 11 399125 93 110190070
Movement disorder 26.37 10.46 223 398913 36181 110153982
Stress cardiomyopathy 26.34 10.46 12 399124 15794 110174369
Chronic idiopathic pain syndrome 26.27 10.46 14 399122 218 110189945
Myocardial infarction 26.15 10.46 892 398244 191191 109998972
Hypothyroidism 26.11 10.46 155 398981 72744 110117419
Personality disorder 26.10 10.46 7 399129 12830 110177333
Mania 26.06 10.46 22 399114 20774 110169389
Underdose 26.04 10.46 347 398789 63207 110126956
Apathy 26.04 10.46 13 399123 16226 110173937
Psychomotor hyperactivity 25.97 10.46 21 399115 20256 110169907
Cardiomyopathy 25.94 10.46 51 399085 33474 110156689
Bradykinesia 25.84 10.46 4 399132 10784 110179379
Hypophagia 25.80 10.46 100 399036 52526 110137637
Blood pressure decreased 25.77 10.46 278 398858 114813 110075350
Rash macular 25.71 10.46 64 399072 38622 110151541
Hypertensive crisis 25.70 10.46 30 399106 24342 110165821
Synovial disorder 25.69 10.46 42 399094 2965 110187198
Akathisia 25.54 10.46 15 399121 17098 110173065
Hepatitis 25.52 10.46 462 398674 89592 110100571
Therapy cessation 25.51 10.46 80 399056 44777 110145386
Eosinophilic granulomatosis with polyangiitis 25.51 10.46 4 399132 10682 110179481
Device leakage 25.50 10.46 13 399123 16035 110174128
Multiple-drug resistance 25.47 10.46 8 399128 13227 110176936
Catatonia 25.29 10.46 5 399131 11295 110178868
Immobile 25.28 10.46 73 399063 7629 110182534
Entropion 25.28 10.46 11 399125 106 110190057
Blood magnesium decreased 25.25 10.46 21 399115 19975 110170188
Bone cyst 25.12 10.46 46 399090 3557 110186606
Red blood cell sedimentation rate 24.99 10.46 57 399079 5157 110185006
Myopathy 24.97 10.46 32 399104 24928 110165235
Aspiration 24.90 10.46 45 399091 30488 110159675
Muscle rigidity 24.89 10.46 30 399106 24001 110166162
Renal cancer 24.87 10.46 8 399128 13026 110177137
Rhinovirus infection 24.80 10.46 6 399130 11783 110178380
Motor dysfunction 24.72 10.46 31 399105 24375 110165788
Spinal pain 24.69 10.46 132 399004 18383 110171780
Benign abdominal neoplasm 24.62 10.46 15 399121 305 110189858
Hepatic function abnormal 24.55 10.46 205 398931 89090 110101073
Bronchiectasis 24.54 10.46 60 399076 36433 110153730
Contusion 24.47 10.46 1053 398083 232308 109957855
Haemolysis 24.36 10.46 13 399123 15626 110174537
Disability assessment scale score increased 24.26 10.46 50 399086 4220 110185943
Wrong product administered 24.22 10.46 5 399131 10955 110179208
Abnormal loss of weight 24.12 10.46 4 399132 10253 110179910
Drug level decreased 24.02 10.46 19 399117 18529 110171634
Ataxia 24.00 10.46 45 399091 30063 110160100
Palpitations 23.95 10.46 417 398719 158795 110031368
Metastases to liver 23.94 10.46 58 399078 35328 110154835
Glycosylated haemoglobin increased 23.92 10.46 30 399106 23589 110166574
Spinal osteoarthritis 23.67 10.46 139 398997 20044 110170119
Synovial fluid analysis 23.66 10.46 38 399098 2643 110187520
Gangrene 23.44 10.46 15 399121 16326 110173837
Pneumonia fungal 23.37 10.46 12 399124 14742 110175421
Blood test abnormal 23.36 10.46 42 399094 28512 110161651
Haematoma 23.31 10.46 120 399016 58356 110131807
Shock haemorrhagic 23.27 10.46 39 399097 27208 110162955
Small intestinal obstruction 23.24 10.46 51 399085 32162 110158001
Blood albumin decreased 23.23 10.46 40 399096 27612 110162551
Appendicitis 23.17 10.46 42 399094 28422 110161741
Substance abuse 23.17 10.46 8 399128 12455 110177708
Gout 23.14 10.46 62 399074 36504 110153659
Serum ferritin increased 23.09 10.46 7 399129 11840 110178323
Hunger 23.05 10.46 64 399072 6540 110183623
Hepatomegaly 22.97 10.46 26 399110 21388 110168775
Peritonitis bacterial 22.87 10.46 5 399131 10528 110179635
Paranasal sinus inflammation 22.79 10.46 14 399122 289 110189874
Procedural pain 22.74 10.46 60 399076 35505 110154658
Acute myocardial infarction 22.73 10.46 193 398943 83584 110106579
Systemic infection 22.71 10.46 4 399132 9815 110180348
Tenosynovitis stenosans 22.64 10.46 44 399092 3559 110186604
Gastrointestinal haemorrhage 22.56 10.46 441 398695 165077 110025086
Nightmare 22.56 10.46 227 398909 38636 110151527
Bacterial sepsis 22.54 10.46 5 399131 10421 110179742
Pseudomonal sepsis 22.49 10.46 3 399133 9043 110181120
Limb discomfort 22.46 10.46 236 398900 40618 110149545
Metastases to bone 22.36 10.46 50 399086 31322 110158841
Subarachnoid haemorrhage 22.29 10.46 46 399090 29656 110160507
Ileal ulcer 22.18 10.46 30 399106 1787 110188376
Product monitoring error 22.10 10.46 3 399133 8924 110181239
Back disorder 21.95 10.46 140 398996 20782 110169381
Flatulence 21.94 10.46 105 399031 52044 110138119
Hypomania 21.86 10.46 5 399131 10205 110179958
Sickle cell anaemia with crisis 21.84 10.46 4 399132 9541 110180622
Adjustment disorder 21.74 10.46 6 399130 10789 110179374
Staphylococcal bacteraemia 21.73 10.46 17 399119 16671 110173492
Gynaecomastia 21.66 10.46 4 399132 9486 110180677
Coordination abnormal 21.65 10.46 36 399100 25192 110164971
Food allergy 21.63 10.46 24 399112 19924 110170239
Proteinuria 21.63 10.46 73 399063 39945 110150218
Pharyngitis 21.61 10.46 160 398976 24938 110165225
Blood calcium increased 21.51 10.46 20 399116 18020 110172143
Cerebrovascular accident 21.22 10.46 495 398641 180789 110009374
Vulval disorder 21.19 10.46 21 399115 892 110189271
Pharyngeal oedema 21.15 10.46 116 399020 16312 110173851
Tooth infection 21.09 10.46 145 398991 22071 110168092
Atrioventricular block 20.97 10.46 18 399118 16859 110173304
Tuberculin test positive 20.90 10.46 43 399093 3625 110186538
Dialysis 20.85 10.46 24 399112 19595 110170568
Upper limb fracture 20.83 10.46 138 398998 20750 110169413
Lung consolidation 20.77 10.46 6 399130 10470 110179693
Pneumothorax 20.73 10.46 62 399074 35223 110154940
Myofascial pain syndrome 20.73 10.46 35 399101 2538 110187625
Carbuncle 20.67 10.46 26 399110 1441 110188722
Granulocytopenia 20.66 10.46 10 399126 12705 110177458
Aspartate aminotransferase increased 20.64 10.46 430 398706 159506 110030657
Paradoxical drug reaction 20.64 10.46 5 399131 9812 110180351
Drug level above therapeutic 20.59 10.46 8 399128 11580 110178583
Amblyopia 20.51 10.46 13 399123 284 110189879
Injection site pain 20.50 10.46 487 398649 177435 110012728
Peripheral sensory neuropathy 20.47 10.46 18 399118 16662 110173501
Oesophageal fibrosis 20.43 10.46 11 399125 175 110189988
Acidosis 20.43 10.46 31 399105 22500 110167663
Intestinal ischaemia 20.42 10.46 17 399119 16162 110174001
Gingival bleeding 20.30 10.46 25 399111 19814 110170349
Blood glucose decreased 20.21 10.46 48 399088 29440 110160723
Alcohol poisoning 20.17 10.46 4 399132 9016 110181147
Meniscus injury 20.16 10.46 68 399068 7725 110182438
Dysphonia 20.12 10.46 176 398960 75753 110114410
Heparin-induced thrombocytopenia 20.12 10.46 8 399128 11416 110178747
Pulmonary toxicity 20.03 10.46 121 399015 17625 110172538
Osteogenesis imperfecta 19.91 10.46 19 399117 770 110189393
Pulmonary haemorrhage 19.91 10.46 18 399118 16438 110173725
Altered state of consciousness 19.86 10.46 124 399012 57502 110132661
Fear of injection 19.83 10.46 74 399062 8837 110181326
Retching 19.81 10.46 32 399104 22650 110167513
Accidental exposure to product 19.72 10.46 103 399033 49905 110140258
Lipase increased 19.67 10.46 23 399113 18649 110171514
Dermatitis atopic 19.64 10.46 39 399097 25502 110164661
Polyuria 19.61 10.46 21 399115 17717 110172446
Affect lability 19.59 10.46 23 399113 18614 110171549
Femur fracture 19.56 10.46 246 398890 44223 110145940
Skin toxicity 19.55 10.46 9 399127 11774 110178389
Weight fluctuation 19.54 10.46 142 398994 22003 110168160
Inflammatory pain 19.50 10.46 26 399110 1527 110188636
Diabetes mellitus inadequate control 19.21 10.46 50 399086 29725 110160438
Hallucinations, mixed 19.14 10.46 4 399132 8689 110181474
Catheter site infection 19.08 10.46 3 399133 7997 110182166
Vertigo 18.98 10.46 211 398925 86659 110103504
Product used for unknown indication 18.96 10.46 29 399107 1934 110188229
Personality change 18.89 10.46 8 399128 10994 110179169
Infusion site pain 18.84 10.46 21 399115 17398 110172765
Central nervous system lesion 18.83 10.46 17 399119 15536 110174627
Rales 18.83 10.46 38 399098 24701 110165462
Intestinal perforation 18.81 10.46 29 399107 20915 110169248
Bronchial wall thickening 18.75 10.46 38 399098 3169 110186994
Atrial flutter 18.70 10.46 37 399099 24225 110165938
Atrial tachycardia 18.67 10.46 5 399131 9173 110180990
Drug dose omission by device 18.63 10.46 15 399121 14501 110175662
Inflammatory bowel disease 18.61 10.46 63 399073 7171 110182992
Bronchospasm 18.59 10.46 52 399084 30187 110159976
Dysuria 18.56 10.46 134 399002 60097 110130066
Lip swelling 18.53 10.46 107 399029 50560 110139603
Acute generalised exanthematous pustulosis 18.51 10.46 31 399105 21633 110168530
Haemodialysis 18.48 10.46 22 399114 17697 110172466
Device use error 18.40 10.46 5 399131 9084 110181079
Hypocholesterolaemia 18.39 10.46 58 399078 6363 110183800
Xyphoid retraction 18.36 10.46 10 399126 163 110190000
Squamous cell carcinoma of skin 18.33 10.46 21 399115 17182 110172981
Erythema 18.32 10.46 862 398274 290585 109899578
Carotid artery thrombosis 18.24 10.46 6 399130 9632 110180531
Burns second degree 18.22 10.46 3 399133 7730 110182433
Gastrointestinal toxicity 18.07 10.46 84 399052 11064 110179099
Ileus 18.05 10.46 54 399082 30675 110159488
Escherichia urinary tract infection 18.02 10.46 19 399117 16143 110174020
Hypocalcaemia 18 10.46 150 398986 65216 110124947
Medulloblastoma 17.86 10.46 9 399127 124 110190039
Acute pulmonary oedema 17.83 10.46 21 399115 16975 110173188
Allergy to chemicals 17.80 10.46 38 399098 3287 110186876
Enteritis 17.71 10.46 26 399110 19130 110171033
Jaundice cholestatic 17.65 10.46 16 399120 14592 110175571
Blood pressure systolic increased 17.64 10.46 408 398728 82583 110107580
Blood pressure diastolic abnormal 17.58 10.46 156 398980 25659 110164504
Pregnancy of partner 17.52 10.46 12 399124 300 110189863
Vision blurred 17.51 10.46 344 398792 128678 110061485
Melaena 17.51 10.46 161 398975 68596 110121567
Joint prosthesis user 17.44 10.46 7 399129 54 110190109
Lymphopenia 17.42 10.46 80 399056 40090 110150073
Cachexia 17.25 10.46 13 399123 12992 110177171
Cholestatic liver injury 17.07 10.46 3 399133 7373 110182790
Mental disorder 16.97 10.46 77 399059 38714 110151449
Bone marrow oedema 16.93 10.46 29 399107 2127 110188036
Hiccups 16.89 10.46 13 399123 12856 110177307
Ageusia 16.89 10.46 28 399108 19617 110170546
Respiratory acidosis 16.87 10.46 15 399121 13811 110176352
Muscular weakness 16.87 10.46 1076 398060 247392 109942771
Genital haemorrhage 16.68 10.46 3 399133 7249 110182914
Cardiac failure congestive 16.66 10.46 416 398720 150584 110039579
Stevens-Johnson syndrome 16.65 10.46 100 399036 46801 110143362
Postoperative adhesion 16.61 10.46 15 399121 566 110189597
Cerebral haematoma 16.55 10.46 7 399129 9625 110180538
Respiratory tract infection 16.43 10.46 172 398964 71445 110118718
Eosinophil count increased 16.32 10.46 32 399104 21026 110169137
Body temperature increased 16.25 10.46 123 399013 54590 110135573
Second primary malignancy 16.24 10.46 25 399111 18043 110172120
Eye pruritus 16.24 10.46 62 399074 32713 110157450
Respiratory symptom 16.19 10.46 18 399118 14927 110175236
Normochromic normocytic anaemia 16.13 10.46 14 399122 13043 110177120
Systemic inflammatory response syndrome 16.10 10.46 14 399122 13029 110177134
Basal cell carcinoma 16.07 10.46 241 398895 45029 110145134
Electrocardiogram QRS complex prolonged 16.04 10.46 14 399122 13007 110177156
Arterial occlusive disease 15.97 10.46 19 399117 15289 110174874
Hepatitis acute 15.90 10.46 27 399109 18739 110171424
Splenic embolism 15.88 10.46 10 399126 216 110189947
Cardiac failure acute 15.87 10.46 40 399096 24038 110166125
Nail injury 15.80 10.46 17 399119 796 110189367
Toxic encephalopathy 15.75 10.46 19 399117 15195 110174968
Granuloma 15.75 10.46 72 399064 9418 110180745
Cardiac failure chronic 15.67 10.46 16 399120 13795 110176368
Syndesmophyte 15.61 10.46 7 399129 73 110190090
Blood uric acid increased 15.60 10.46 34 399102 21495 110168668
Injection site swelling 15.60 10.46 145 398991 61645 110128518
Hypopnoea 15.58 10.46 11 399125 11369 110178794
Hepatic cirrhosis 15.48 10.46 336 398800 67290 110122873
Ear infection 15.44 10.46 315 398821 62417 110127746
Blood immunoglobulin E increased 15.37 10.46 4 399132 7478 110182685
Uterine perforation 15.36 10.46 3 399133 6837 110183326
Hospitalisation 15.33 10.46 394 398742 142099 110048064
Speech disorder 15.32 10.46 145 398991 61424 110128739
Eye injury 15.30 10.46 62 399074 7693 110182470
Premature labour 15.23 10.46 7 399129 9165 110180998
Abdominal pain 15.18 10.46 1620 397516 511369 109678794
Abortion induced 15.16 10.46 5 399131 8014 110182149
Encephalitis 15.15 10.46 28 399108 18811 110171352
Multiple drug therapy 15.15 10.46 5 399131 8009 110182154
Tardive dyskinesia 15.10 10.46 16 399120 13563 110176600
Adverse drug reaction 15.07 10.46 493 398643 105066 110085097
Lip and/or oral cavity cancer 15.06 10.46 20 399116 1170 110188993
Arteriospasm coronary 15.02 10.46 7 399129 9093 110181070
Supraventricular tachycardia 15.01 10.46 42 399094 24380 110165783
Tension headache 14.97 10.46 8 399128 9610 110180553
Muscle swelling 14.92 10.46 19 399117 1066 110189097
Vomiting 14.90 10.46 2980 396156 907695 109282468
Aplasia pure red cell 14.86 10.46 8 399128 9570 110180593
Blood pressure systolic abnormal 14.83 10.46 146 398990 24704 110165459
Diaphragmatic injury 14.82 10.46 8 399128 128 110190035
Anxiety 14.80 10.46 1442 397694 343636 109846527
Autoimmune hepatitis 14.79 10.46 19 399117 14785 110175378
Rash pruritic 14.78 10.46 461 398675 97608 110092555
Blood urea increased 14.73 10.46 127 399009 54830 110135333
SARS-CoV-2 test positive 14.69 10.46 24 399112 16911 110173252
Metastases to lung 14.67 10.46 39 399097 23024 110167139
Hospice care 14.67 10.46 14 399122 12459 110177704
Osteomyelitis 14.65 10.46 199 398937 36401 110153762
Knee operation 14.55 10.46 57 399079 6965 110183198
Prothrombin time prolonged 14.47 10.46 25 399111 17236 110172927
Device breakage 14.46 10.46 17 399119 13752 110176411
Thrombocytosis 14.43 10.46 10 399126 10434 110179729
Injection site pruritus 14.40 10.46 117 399019 51141 110139022
Dizziness postural 14.34 10.46 19 399117 14590 110175573
Hypovolaemic shock 14.28 10.46 19 399117 14564 110175599
Gelatinous transformation of the bone marrow 14.27 10.46 5 399131 25 110190138
Macular degeneration 14.26 10.46 36 399100 21623 110168540
Bone density decreased 14.23 10.46 103 399033 15939 110174224
Metastases to central nervous system 14.20 10.46 39 399097 22778 110167385
Ammonia increased 14.17 10.46 6 399130 8244 110181919
Anal incontinence 14.08 10.46 37 399099 21927 110168236
Dermatitis acneiform 14.07 10.46 15 399121 12680 110177483
Vaginal haemorrhage 14.06 10.46 45 399091 25029 110165134
Body temperature decreased 14.04 10.46 199 398937 36736 110153427
Abdominal pain lower 14.03 10.46 78 399058 37205 110152958
Atrioventricular block second degree 13.97 10.46 6 399130 8175 110181988
Nasal congestion 13.96 10.46 260 398876 98022 110092141
Coma scale abnormal 13.85 10.46 9 399127 9717 110180446
Aortic stenosis 13.85 10.46 16 399120 13043 110177120
Lung opacity 13.79 10.46 13 399123 11639 110178524
Sneezing 13.69 10.46 64 399072 31920 110158243
Escherichia bacteraemia 13.69 10.46 10 399126 10154 110180009
Conjunctivitis allergic 13.68 10.46 4 399132 6927 110183236
Hypoventilation 13.68 10.46 6 399130 8075 110182088
Cerebellar syndrome 13.67 10.46 3 399133 6299 110183864
Exercise tolerance decreased 13.66 10.46 14 399122 12053 110178110
Eating disorder 13.65 10.46 61 399075 30797 110159366
Neurological symptom 13.65 10.46 22 399114 15586 110174577
Urinary incontinence 13.60 10.46 111 399025 48476 110141687
Thirst 13.59 10.46 37 399099 21670 110168493
Anosmia 13.53 10.46 15 399121 12457 110177706
Prostate cancer 13.49 10.46 80 399056 37561 110152602
Ketoacidosis 13.49 10.46 10 399126 10077 110180086
Mood swings 13.46 10.46 40 399096 22772 110167391
Congestive cardiomyopathy 13.44 10.46 19 399117 14200 110175963
Carotid artery occlusion 13.42 10.46 9 399127 9556 110180607
Spinal stenosis 13.42 10.46 116 399020 18940 110171223
Feeling cold 13.40 10.46 70 399066 33917 110156246
Metabolic disorder 13.32 10.46 11 399125 10499 110179664
Acute coronary syndrome 13.30 10.46 41 399095 23071 110167092
Arrhythmia 13.29 10.46 174 398962 69401 110120762
Mass excision 13.22 10.46 11 399125 371 110189792
Delirium 13.20 10.46 605 398531 134420 110055743
Small intestine ulcer 13.18 10.46 16 399120 855 110189308
Bladder cancer 13.15 10.46 34 399102 20258 110169905
Left ventricular failure 13.14 10.46 13 399123 11376 110178787
Endoscopic retrograde cholangiopancreatography 13.14 10.46 9 399127 225 110189938
Wrist fracture 13.04 10.46 93 399043 14324 110175839
Hypotonia 13.02 10.46 23 399113 15722 110174441
Hypertriglyceridaemia 13.00 10.46 24 399112 16130 110174033
Pulmonary mass 12.99 10.46 80 399056 37221 110152942
Vasculitis 12.99 10.46 76 399060 35797 110154366
Complication of device insertion 12.83 10.46 8 399128 8830 110181333
Gingival ulceration 12.83 10.46 19 399117 1231 110188932
Malignant polyp 12.82 10.46 8 399128 170 110189993
Tongue disorder 12.80 10.46 92 399044 14206 110175957
Respiration abnormal 12.76 10.46 10 399126 9799 110180364
Incorrect dose administered 12.69 10.46 281 398855 103360 110086803
Urinary retention 12.68 10.46 176 398960 69507 110120656
Oesophageal pain 12.63 10.46 44 399092 5081 110185082
Mycotic allergy 12.58 10.46 3 399133 5951 110184212
Optic neuritis 12.55 10.46 13 399123 11134 110179029
Musculoskeletal discomfort 12.49 10.46 135 399001 23403 110166760
Cervical radiculopathy 12.47 10.46 22 399114 1652 110188511
Endophthalmitis 12.47 10.46 7 399129 8180 110181983
Diffuse large B-cell lymphoma 12.46 10.46 24 399112 15874 110174289
Pruritus genital 12.45 10.46 4 399132 6518 110183645
Device related sepsis 12.44 10.46 6 399130 7641 110182522
Coccydynia 12.42 10.46 28 399108 2513 110187650
Orchitis noninfective 12.33 10.46 4 399132 15 110190148
Device malfunction 12.25 10.46 49 399087 25509 110164654
Hepatic pain 12.20 10.46 41 399095 4649 110185514
Herpes simplex 12.18 10.46 24 399112 15740 110174423
Enterobacter infection 12.14 10.46 3 399133 5808 110184355
Tongue cancer recurrent 12.13 10.46 4 399132 16 110190147
Fluid intake reduced 12.12 10.46 5 399131 6981 110183182
Coronavirus infection 12.08 10.46 10 399126 9535 110180628
Alanine aminotransferase abnormal 12.08 10.46 66 399070 9268 110180895
Acute lymphocytic leukaemia recurrent 12.07 10.46 3 399133 5784 110184379
Scleritis 12.05 10.46 45 399091 5375 110184788
Tooth disorder 12.04 10.46 161 398975 29348 110160815
Cold sweat 12.03 10.46 40 399096 21991 110168172
Pneumonia cytomegaloviral 12.03 10.46 5 399131 6949 110183214
Erysipelas 12.03 10.46 18 399118 13140 110177023
Rash papular 12.01 10.46 55 399081 27584 110162579
Pneumatosis intestinalis 12.00 10.46 8 399128 8521 110181642
Superinfection 11.99 10.46 3 399133 5760 110184403
Vitamin B12 decreased 11.99 10.46 44 399092 5213 110184950
Oesophagitis 11.97 10.46 58 399078 28657 110161506
Sputum increased 11.95 10.46 3 399133 5748 110184415
Pollakiuria 11.91 10.46 102 399034 44093 110146070
Subcutaneous drug absorption impaired 11.89 10.46 57 399079 7602 110182561
Sciatic nerve neuropathy 11.89 10.46 12 399124 521 110189642
Platelet count abnormal 11.73 10.46 4 399132 6278 110183885
Hepatocellular carcinoma 11.72 10.46 11 399125 9869 110180294
Sideroblastic anaemia 11.69 10.46 11 399125 438 110189725
Carpal tunnel syndrome 11.68 10.46 129 399007 22481 110167682
Neutrophilia 11.68 10.46 12 399124 10317 110179846
Ischaemic stroke 11.68 10.46 94 399042 41169 110148994
Oculomucocutaneous syndrome 11.66 10.46 10 399126 352 110189811
Drug level below therapeutic 11.64 10.46 15 399121 11658 110178505
Ankle fracture 11.62 10.46 116 399020 19703 110170460
Myalgia intercostal 11.58 10.46 4 399132 19 110190144
Skin neoplasm excision 11.58 10.46 24 399112 2034 110188129
Potentiating drug interaction 11.57 10.46 15 399121 11628 110178535
Amylase increased 11.57 10.46 17 399119 12502 110177661
Incoherent 11.55 10.46 8 399128 8350 110181813
Mood altered 11.54 10.46 39 399097 21336 110168827
Chest expansion decreased 11.54 10.46 8 399128 204 110189959
Escherichia sepsis 11.54 10.46 12 399124 10260 110179903
Patellofemoral pain syndrome 11.52 10.46 12 399124 541 110189622
Transplant dysfunction 11.47 10.46 8 399128 8320 110181843
Nystagmus 11.42 10.46 15 399121 11562 110178601
Cross sensitivity reaction 11.39 10.46 3 399133 5564 110184599
Food aversion 11.38 10.46 21 399115 1634 110188529
Spondylitis 11.36 10.46 75 399061 11263 110178900
Pneumocystis jirovecii pneumonia 11.35 10.46 99 399037 42636 110147527
Seronegative arthritis 11.34 10.46 84 399052 13093 110177070
Endotracheal intubation 11.33 10.46 4 399132 6140 110184023
Abnormal faeces 11.30 10.46 10 399126 9226 110180937
Head injury 11.27 10.46 100 399036 42917 110147246
N-terminal prohormone brain natriuretic peptide increased 11.26 10.46 4 399132 6117 110184046
Liver abscess 11.25 10.46 7 399129 7732 110182431
Lung adenocarcinoma stage IV 11.20 10.46 12 399124 559 110189604
Tendinous contracture 11.17 10.46 9 399127 290 110189873
Dry eye 11.16 10.46 272 398864 55521 110134642
Blindness 11.15 10.46 81 399055 36278 110153885
Skin reaction 11.13 10.46 39 399097 21105 110169058
Forced expiratory volume decreased 11.12 10.46 19 399117 13157 110177006
Ventricular arrhythmia 11.09 10.46 12 399124 10075 110180088
Allergic reaction to excipient 11.00 10.46 14 399122 785 110189378
Long QT syndrome 10.97 10.46 6 399130 7112 110183051
Urine abnormality 10.94 10.46 10 399126 9086 110181077
Brain death 10.94 10.46 5 399131 6568 110183595
Upper respiratory tract infection 10.92 10.46 376 398760 130952 110059211
Arachnoiditis 10.91 10.46 16 399120 1028 110189135
Subdural haemorrhage 10.90 10.46 5 399131 6553 110183610
Coronary artery stenosis 10.89 10.46 86 399050 13672 110176491
Vaginal discharge 10.86 10.46 31 399105 17877 110172286
General physical condition abnormal 10.84 10.46 7 399129 7583 110182580
Product preparation error 10.83 10.46 14 399122 10865 110179298
Portal vein thrombosis 10.80 10.46 6 399130 7052 110183111
Cardiac tamponade 10.80 10.46 15 399121 11292 110178871
HLA marker study positive 10.77 10.46 8 399128 228 110189935
Bradyphrenia 10.76 10.46 16 399120 11712 110178451
Decubitus ulcer 10.74 10.46 32 399104 18204 110171959
Cytomegalovirus test positive 10.74 10.46 6 399130 7030 110183133
Hepatitis C 10.74 10.46 18 399118 12555 110177608
Overweight 10.69 10.46 49 399087 6415 110183748
Breast cyst excision 10.68 10.46 4 399132 25 110190138
Neutrophil count 10.67 10.46 10 399126 396 110189767
Hepatitis chronic persistent 10.61 10.46 3 399133 6 110190157
Ventricular hypokinesia 10.59 10.46 15 399121 11199 110178964
Mycobacterium avium complex infection 10.54 10.46 4 399132 5873 110184290
Tubo-ovarian abscess 10.50 10.46 10 399126 404 110189759
Sinus disorder 10.48 10.46 72 399064 32656 110157507
Hypersensitivity pneumonitis 10.47 10.46 3 399133 5262 110184901

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC L01XX33 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
ATC M01AH01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
ATC N02AJ16 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:50629 cyclooxygenase 2 inhibitor
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:149553 anticoronaviral agent
CHEBI has role CHEBI:176497 geroprotector

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N02AJ Opioids in combination with non-opioid analgesics 9 drugs
acetylsalicylic acidcodeinedexketoprofendihydrocodeinehydrocodoneibuprofenoxycodoneparacetamoltramadol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.79 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 10238668 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 10548909 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 DISCN TABLET ORAL 11478488 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 10376527 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 10722456 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 10799517 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 9572819 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 9795620 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX PHARMS N212157 May 5, 2020 RX SOLUTION ORAL 9949990 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.24 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.85 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.48 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.14 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.92 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.18 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.86 DRUG MATRIX
Carbonic anhydrase 1 Enzyme Ki 4.30 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.06 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.80 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 7.74 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.76 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.10 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.66 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 4.44 CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 5.03 DRUG MATRIX
Histone deacetylase 1 Enzyme IC50 5.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 6.19 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 7.31 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.13 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 6.16 CHEMBL
Mitogen-activated protein kinase 14 Kinase IC50 6.09 CHEMBL
Cytochrome c oxidase subunit 2 Enzyme IC50 6.27 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase IC50 4.32 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 7.01 CHEMBL
Prostaglandin E synthase Enzyme IC50 6.37 CHEMBL
Carbonic anhydrase 2 Enzyme IC50 7.68 WOMBAT-PK
Progesterone receptor Transcription factor Ki 5.63 DRUG MATRIX
Prostaglandin G/H synthase 2 Enzyme IC50 9.29 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 9.15 CHEMBL
Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein Enzyme IC50 6.05 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.54 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.43 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.24 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.85 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.25 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.40 CHEMBL
Carbonic anhydrase Enzyme Ki 6.85 CHEMBL
Carbonic anhydrase Enzyme Ki 4.41 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.35 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.11 CHEMBL
Carbonic anhydrase Enzyme Ki 6.97 CHEMBL
Carbonic anhydrase Enzyme Ki 7.68 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase Enzyme Ki 6.94 CHEMBL
Alpha carbonic anhydrase Enzyme Ki 7.47 CHEMBL
Cytochrome c oxidase subunit 2 Enzyme IC50 7.22 CHEMBL
Carbonic anhydrase Enzyme Ki 6.16 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.51 CHEMBL
Astrosclerin-3 Enzyme Ki 6.14 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.99 CHEMBL
Delta carbonic anhydrase Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.15 CHEMBL
Cytochrome c oxidase subunit 1 Enzyme IC50 4.61 CHEMBL
Carbonic anhydrase Enzyme Ki 6.76 CHEMBL
Carbonic anhydrase, alpha family Enzyme Ki 6.01 CHEMBL
Carbonate dehydratase Enzyme Ki 8.16 CHEMBL

External reference:

IDSource
4021143 VUID
N0000148596 NUI
D00567 KEGG_DRUG
140587 RXNORM
C0538927 UMLSCUI
CHEBI:41423 CHEBI
CEL PDB_CHEM_ID
CHEMBL118 ChEMBL_ID
DB00482 DRUGBANK_ID
D000068579 MESH_DESCRIPTOR_UI
2662 PUBCHEM_CID
2892 IUPHAR_LIGAND_ID
7767 INN_ID
JCX84Q7J1L UNII
14020 MMSL
174627 MMSL
7872 MMSL
d04380 MMSL
007731 NDDF
116081000 SNOMEDCT_US
370187009 SNOMEDCT_US
4021143 VANDF
JCX84Q7J1L INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3982 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3983 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3984 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3985 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8571 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0615-8572 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-7550 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0904-7551 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-917 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-918 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-929 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-953 CAPSULE 200 mg ORAL ANDA 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 10544-967 CAPSULE 200 mg ORAL NDA authorized generic 33 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 11788-112 CAPSULE 50 mg ORAL ANDA 21 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 11788-113 CAPSULE 100 mg ORAL ANDA 21 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 11788-114 CAPSULE 200 mg ORAL ANDA 21 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 11788-115 CAPSULE 400 mg ORAL ANDA 21 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-307 CAPSULE 50 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-310 CAPSULE 400 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-441 CAPSULE 100 mg ORAL ANDA 27 sections
celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 13668-442 CAPSULE 200 mg ORAL ANDA 27 sections
VYSCOXA HUMAN PRESCRIPTION DRUG LABEL 1 15370-501 Suspension 10 mg ORAL NDA 30 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 16590-045 CAPSULE 100 mg ORAL NDA 33 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 16590-046 CAPSULE 200 mg ORAL NDA 33 sections
CELECOXIB HUMAN PRESCRIPTION DRUG LABEL 1 16714-731 CAPSULE 50 mg ORAL ANDA 26 sections
CELECOXIB HUMAN PRESCRIPTION DRUG LABEL 1 16714-732 CAPSULE 100 mg ORAL ANDA 26 sections
CELECOXIB HUMAN PRESCRIPTION DRUG LABEL 1 16714-733 CAPSULE 200 mg ORAL ANDA 26 sections
CELECOXIB HUMAN PRESCRIPTION DRUG LABEL 1 16714-734 CAPSULE 400 mg ORAL ANDA 26 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 21695-022 CAPSULE 100 mg ORAL NDA 33 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 21695-023 CAPSULE 200 mg ORAL NDA 33 sections