gliclazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1299 21187-98-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gliclazide
  • diabezidum
  • diabrezide
  • diabyl
  • diaprel
  • glimicron
  • glinormax
  • glyzide
  • gliclazid
  • dizalid
  • S 1702
An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.
  • Molecular weight: 323.41
  • Formula: C15H21N3O3S
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 78.51
  • ALOGS: -3.23
  • ROTB: 2

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.13 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.43 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.41 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 16.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.528 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.549 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 47.424 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.716 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 9.740 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 8.320 % High 1
herg hERG pIC50 4.485 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.553 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.673 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 4.390 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,MAPK7,PDK1,PDK2,PDK4,PRKDC 13
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.972 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.188 High 1
mh-clint Mouse hepatocyte intrinsic clearance 11.695 High 1
mppb Mouse plasma protein binding (% unbound) 9.500 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.140 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 8.110 % High 1
rat-kpuu-brain Rat brain Kpuu 0.149 % High 1
rh-clint Rat hepatocyte intrinsic clearance 7.691 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 86.560 % High 1
rppb Rat plasma protein binding (% unbound) 4.730 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 933.254 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1972 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 863.44 13.79 522 51134 69326 90507465
Lactic acidosis 831.88 13.79 455 51201 50008 90526783
Diabetes mellitus inadequate control 481.66 13.79 228 51428 18456 90558335
Acute kidney injury 461.50 13.79 726 50930 319661 90257130
Gangrene 378.14 13.79 172 51484 12704 90564087
Arterial occlusive disease 371.02 13.79 168 51488 12278 90564513
Diabetic ketoacidosis 339.38 13.79 197 51459 24210 90552581
Carotid artery thrombosis 326.86 13.79 140 51516 8952 90567839
Neurologic neglect syndrome 323.90 13.79 138 51518 8709 90568082
Motor dysfunction 321.06 13.79 175 51481 19055 90557736
Adjustment disorder 302.84 13.79 135 51521 9507 90567284
Hyperkalaemia 298.02 13.79 267 51389 64697 90512094
Personality disorder 290.81 13.79 142 51514 12302 90564489
Skin haemorrhage 272.14 13.79 163 51493 21217 90555574
Sensory loss 259.55 13.79 149 51507 17926 90558865
Hemiplegia 250.35 13.79 140 51516 16020 90560771
Hyperglycaemia 246.73 13.79 216 51440 50754 90526037
Angina pectoris 245.94 13.79 193 51463 38967 90537824
Affect lability 243.72 13.79 143 51513 17920 90558871
Coordination abnormal 231.56 13.79 147 51509 21209 90555582
Sinus congestion 221.02 13.79 157 51499 27267 90549524
Euglycaemic diabetic ketoacidosis 208.21 13.79 91 51565 6110 90570681
Sneezing 206.78 13.79 156 51500 29713 90547078
Eating disorder 199.64 13.79 149 51507 27924 90548867
Cataract 190.53 13.79 220 51436 71872 90504919
Respiratory tract congestion 182.78 13.79 140 51516 27270 90549521
Hemiparesis 176.81 13.79 146 51510 31673 90545118
Aphasia 173.05 13.79 164 51492 42648 90534143
Multiple drug therapy 166.82 13.79 81 51575 6928 90569863
Sinus disorder 166.72 13.79 146 51510 34301 90542490
Palpitations 165.50 13.79 287 51369 136441 90440350
Hyponatraemia 165.17 13.79 283 51373 133255 90443536
Hypoglycaemic coma 158.98 13.79 61 51595 2929 90573862
Blood pressure increased 150.34 13.79 341 51315 196876 90379915
Muscle spasticity 147.91 13.79 138 51518 35184 90541607
Dysarthria 146.86 13.79 168 51488 54314 90522477
Rhinorrhoea 146.30 13.79 214 51442 88102 90488689
Arthropathy 144.56 13.79 19 51637 366223 90210568
Metabolic acidosis 143.90 13.79 168 51488 55508 90521283
Cystitis 136.50 13.79 179 51477 66539 90510252
Loss of employment 134.40 13.79 54 51602 2933 90573858
Ketoacidosis 134.18 13.79 65 51591 5530 90571261
Malignant mediastinal neoplasm 129.01 13.79 43 51613 1365 90575426
Glycosylated haemoglobin increased 127.48 13.79 90 51566 15472 90561319
Wound 126.31 13.79 13 51643 302967 90273824
Diabetic metabolic decompensation 122.52 13.79 45 51611 1912 90574879
Influenza like illness 121.62 13.79 187 51469 80424 90496367
Helicobacter infection 115.16 13.79 3 51653 226847 90349944
Synovitis 112.78 13.79 25 51631 329727 90247064
Infusion related reaction 111.55 13.79 49 51607 416731 90160060
Maternal exposure during pregnancy 108.60 13.79 35 51621 360028 90216763
Skin exfoliation 107.33 13.79 161 51495 67752 90509039
Blood glucose increased 105.01 13.79 192 51464 95054 90481737
Fall 104.57 13.79 546 51110 481264 90095527
Treatment failure 104.01 13.79 23 51633 303905 90272886
Stomatitis 99.82 13.79 18 51638 274680 90302111
Blood pressure inadequately controlled 99.33 13.79 55 51601 6169 90570622
Hepatic steatosis 97.99 13.79 113 51543 36832 90539959
Pemphigoid 95.02 13.79 61 51595 8965 90567826
Exercise tolerance decreased 94.59 13.79 57 51599 7494 90569297
Irritable bowel syndrome 94.48 13.79 6 51650 207442 90369349
Blister 94.20 13.79 16 51640 254982 90321809
Chest discomfort 94.20 13.79 229 51427 138136 90438655
Discomfort 89.45 13.79 23 51633 274312 90302479
Impaired healing 85.83 13.79 15 51641 234184 90342607
Hand deformity 85.55 13.79 31 51625 296331 90280460
Hypersensitivity 84.26 13.79 81 51575 454596 90122195
Infection 81.56 13.79 53 51603 362041 90214750
Blood cholesterol increased 81.52 13.79 11 51645 208001 90368790
Malaise 81.49 13.79 592 51064 585394 89991397
Blood immunoglobulin E increased 81.49 13.79 43 51613 4382 90572409
Parkinsonism 81.19 13.79 66 51590 13999 90562792
Blood cholesterol decreased 80.33 13.79 33 51623 1898 90574893
Exposure during pregnancy 79.64 13.79 19 51637 238391 90338400
Swelling 79.59 13.79 73 51583 418985 90157806
Pneumonia aspiration 79.35 13.79 107 51549 40833 90535958
Dementia 78.97 13.79 82 51574 23779 90553012
Fibromyalgia 78.29 13.79 12 51644 206257 90370534
Cerebrovascular accident 77.29 13.79 198 51458 123335 90453456
Melaena 76.86 13.79 97 51559 34700 90542091
Pancreatitis acute 76.53 13.79 93 51563 32022 90544769
Cough 76.44 13.79 413 51243 368549 90208242
Injury 76.01 13.79 11 51645 197338 90379453
Cognitive disorder 75.33 13.79 139 51517 69268 90507523
Muscle injury 75.11 13.79 7 51649 176647 90400144
Dysphagia 74.46 13.79 184 51472 112094 90464697
Urinary retention 73.69 13.79 99 51557 37645 90539146
Death 72.84 13.79 92 51564 456459 90120332
Muscular weakness 71.15 13.79 269 51387 206397 90370394
Cardiac failure 70.05 13.79 177 51479 109319 90467472
Hyperlactacidaemia 70.01 13.79 38 51618 4098 90572693
Peripheral circulatory failure 68.73 13.79 28 51628 1576 90575215
Drug interaction 68.13 13.79 325 51331 276128 90300663
Coma 66.06 13.79 135 51521 72497 90504294
Alopecia 66.04 13.79 113 51543 494958 90081833
Cardiospasm 64.92 13.79 34 51622 3412 90573379
Palmoplantar keratoderma 64.36 13.79 34 51622 3473 90573318
Pruritus genital 63.89 13.79 37 51619 4521 90572270
Neuroglycopenia 63.79 13.79 24 51632 1091 90575700
Completed suicide 63.71 13.79 5 51651 145053 90431738
Hepatic enzyme increased 62.55 13.79 68 51588 360668 90216123
Atrioventricular block first degree 62.34 13.79 46 51610 8465 90568326
Ill-defined disorder 61.22 13.79 15 51641 184876 90391915
Vomiting 61.18 13.79 702 50954 787591 89789200
Influenza 60.67 13.79 196 51460 139068 90437723
Tubulointerstitial nephritis 59.75 13.79 73 51583 25270 90551521
Rash 59.44 13.79 243 51413 795857 89780934
Psoriatic arthropathy 59.23 13.79 28 51628 228307 90348484
Drug ineffective 58.56 13.79 507 51149 1383791 89193000
Psoriasis 58.20 13.79 201 51455 147553 90429238
Joint swelling 57.46 13.79 126 51530 503174 90073617
Sleep terror 56.70 13.79 34 51622 4430 90572361
Condition aggravated 54.28 13.79 167 51489 595378 89981413
Gastric polyps 52.74 13.79 33 51623 4639 90572152
Pericarditis 52.52 13.79 46 51610 270105 90306686
Muscle rigidity 52.51 13.79 52 51604 14257 90562534
Medication error 52.22 13.79 135 51521 84517 90492274
Therapy non-responder 51.76 13.79 8 51648 136696 90440095
Product use in unapproved indication 51.29 13.79 70 51586 336166 90240625
Product dose omission issue 50.53 13.79 55 51601 291632 90285159
C3 glomerulopathy 50.27 13.79 13 51643 164 90576627
Initial insomnia 50.21 13.79 42 51614 9268 90567523
Type 2 diabetes mellitus 49.60 13.79 27 51629 203217 90373574
Urticaria 47.80 13.79 65 51591 312669 90264122
Rheumatic fever 47.71 13.79 14 51642 153107 90423684
Atrial tachycardia 47.57 13.79 34 51622 5956 90570835
Liver injury 47.26 13.79 19 51637 170548 90406243
Adverse event 46.49 13.79 6 51650 117412 90459379
Carotid artery occlusion 45.83 13.79 34 51622 6308 90570483
Hypercholesterolaemia 45.68 13.79 3 51653 100889 90475902
Stupor 45.58 13.79 32 51624 5450 90571341
Tension headache 44.96 13.79 36 51620 7473 90569318
Sleep disorder 44.53 13.79 29 51627 198001 90378790
Syncope 44.24 13.79 171 51485 132492 90444299
Acne 44.19 13.79 67 51589 28440 90548351
Gastric disorder 42.87 13.79 72 51584 33312 90543479
Lower respiratory tract infection 41.52 13.79 49 51607 250610 90326181
Arthritis 41.39 13.79 197 51459 167118 90409673
Renal tubular disorder 39.63 13.79 24 51632 3183 90573608
Upper respiratory tract infection 39.49 13.79 12 51644 128306 90448485
Dermatitis artefacta 39.43 13.79 9 51647 64 90576727
Inappropriate antidiuretic hormone secretion 39.36 13.79 52 51604 19453 90557338
Wound infection 38.56 13.79 7 51649 106395 90470396
Gait inability 37.90 13.79 18 51638 146438 90430353
Bradykinesia 37.39 13.79 31 51625 6757 90570034
Infected dermal cyst 37.29 13.79 13 51643 474 90576317
Road traffic accident 37.08 13.79 8 51648 107618 90469173
Butterfly rash 36.77 13.79 20 51636 2165 90574626
Depressed mood 36.17 13.79 85 51571 50137 90526654
Drug dependence 36.00 13.79 62 51594 29265 90547526
Pancreatic carcinoma 35.58 13.79 33 51623 8344 90568447
Transplant dysfunction 35.25 13.79 27 51629 5255 90571536
Bacterial translocation 35.17 13.79 14 51642 742 90576049
Anosmia 34.68 13.79 35 51621 9813 90566978
Mesenteric panniculitis 33.92 13.79 10 51646 210 90576581
Immunisation 33.80 13.79 19 51637 2194 90574597
Weight increased 33.38 13.79 124 51532 417803 90158988
Periorbital oedema 33.25 13.79 29 51627 6770 90570021
Gastrointestinal disorder 33.09 13.79 255 51401 256432 90320359
Joint noise 33.04 13.79 26 51630 5264 90571527
Vulvovaginal candidiasis 32.97 13.79 23 51633 3877 90572914
Blood glucose decreased 32.06 13.79 52 51604 23377 90553414
Chorea 31.91 13.79 18 51638 2092 90574699
Drug hypersensitivity 31.76 13.79 146 51510 463463 90113328
Product quality issue 31.53 13.79 4 51652 79321 90497470
Pain of skin 31.11 13.79 42 51614 16040 90560751
Hypomagnesaemia 31.00 13.79 65 51591 35523 90541268
Adverse drug reaction 30.73 13.79 14 51642 116687 90460104
Blood creatine increased 30.67 13.79 28 51628 6939 90569852
Blood urea increased 30.62 13.79 59 51597 30354 90546437
Joint range of motion decreased 30.30 13.79 20 51636 135623 90441168
Alopecia scarring 30.26 13.79 9 51647 195 90576596
Blood lactic acid 30.16 13.79 8 51648 112 90576679
Hypoaesthesia 30.09 13.79 86 51570 314124 90262667
Muscle atrophy 29.85 13.79 30 51626 8371 90568420
Nausea 29.71 13.79 835 50821 1109481 89467310
Blood potassium increased 29.69 13.79 47 51609 20702 90556089
Metastases to fallopian tube 29.31 13.79 7 51649 62 90576729
Prescribed underdose 29.30 13.79 4 51652 75015 90501776
Urine output decreased 29.21 13.79 36 51620 12567 90564224
Blood pressure systolic increased 28.99 13.79 86 51570 58259 90518532
Sleep disorder due to general medical condition, insomnia type 28.72 13.79 19 51637 128675 90448116
Blindness 28.55 13.79 53 51603 26515 90550276
Hypotension 28.43 13.79 297 51359 325100 90251691
Urine protein/creatinine ratio increased 28.08 13.79 13 51643 999 90575792
Diabetes mellitus 27.96 13.79 91 51565 64784 90512007
General physical health deterioration 27.93 13.79 106 51550 355009 90221782
Facial pain 27.93 13.79 36 51620 13146 90563645
Blood glucose fluctuation 27.55 13.79 23 51633 5060 90571731
Carcinoid tumour 27.40 13.79 10 51646 417 90576374
Bronchiectasis 27.14 13.79 47 51609 22283 90554508
Cholestatic liver injury 26.64 13.79 20 51636 3777 90573014
Cardiac arrest 26.26 13.79 124 51532 104811 90471980
Faeces discoloured 26.08 13.79 45 51611 21275 90555516
Head injury 26.05 13.79 56 51600 31132 90545659
Glucose urine present 26.04 13.79 12 51644 912 90575879
Neutropenia 25.86 13.79 56 51600 224848 90351943
Tinnitus 25.82 13.79 68 51588 43034 90533757
Lip swelling 25.29 13.79 63 51593 38547 90538244
Rebound psychosis 25.27 13.79 8 51648 215 90576576
Bladder sphincter atony 25.09 13.79 8 51648 220 90576571
Drug ineffective for unapproved indication 24.99 13.79 4 51652 66640 90510151
Transient ischaemic attack 24.73 13.79 67 51589 43109 90533682
Steatorrhoea 24.63 13.79 10 51646 558 90576233
Oedema 24.62 13.79 48 51608 200247 90376544
Ear infection 24.41 13.79 5 51651 69770 90507021
Therapeutic product effect decreased 24.41 13.79 79 51577 277492 90299299
Insulin-like growth factor decreased 24.05 13.79 9 51647 403 90576388
Autoimmune disorder 23.93 13.79 7 51649 76737 90500054
Autoimmune nephritis 23.84 13.79 9 51647 413 90576378
Subarachnoid haemorrhage 23.50 13.79 39 51617 17865 90558926
C-reactive protein abnormal 23.21 13.79 23 51633 127406 90449385
Musculoskeletal stiffness 23.00 13.79 89 51567 296443 90280348
Pseudohallucination 22.78 13.79 7 51649 170 90576621
White blood cell count decreased 22.36 13.79 38 51618 167071 90409720
Prescribed overdose 22.34 13.79 14 51642 97611 90479180
Fear-related avoidance of activities 22.25 13.79 7 51649 184 90576607
Acetonaemia 22.14 13.79 8 51648 324 90576467
Contraindicated product administered 21.80 13.79 101 51555 320038 90256753
Haemoglobin increased 21.74 13.79 24 51632 7457 90569334
Encephalocele 21.60 13.79 7 51649 203 90576588
No adverse event 21.57 13.79 6 51650 67976 90508815
Disease progression 21.53 13.79 35 51621 156580 90420211
Night sweats 21.49 13.79 25 51631 128741 90448050
Torticollis 21.43 13.79 15 51641 2543 90574248
Somnolence 21.25 13.79 197 51459 208887 90367904
Serum serotonin increased 21.22 13.79 7 51649 215 90576576
Nail disorder 21.15 13.79 4 51652 59063 90517728
Delayed graft function 21.13 13.79 12 51644 1413 90575378
Lip dry 21.08 13.79 16 51640 100939 90475852
Bradycardia 20.92 13.79 99 51557 83748 90493043
Neoplasm skin 20.83 13.79 16 51640 3126 90573665
Urine calcium/creatinine ratio increased 20.77 13.79 6 51650 117 90576674
Therapeutic reaction time decreased 20.76 13.79 17 51639 3641 90573150
Wheezing 20.76 13.79 68 51588 238012 90338779
Metastases to bladder 20.68 13.79 7 51649 233 90576558
Aspartate aminotransferase increased 20.63 13.79 17 51639 102920 90473871
Osteoporosis 20.57 13.79 109 51547 96422 90480369
Constipation 20.42 13.79 247 51409 280148 90296643
Hypoprothrombinaemia 20.41 13.79 8 51648 407 90576384
Bone erosion 20.30 13.79 3 51653 53018 90523773
Endometrial cancer stage I 20.08 13.79 7 51649 255 90576536
Cardioactive drug level increased 20.02 13.79 14 51642 2370 90574421
Hypotonia 19.35 13.79 28 51628 11398 90565393
Therapeutic product effect incomplete 19.35 13.79 52 51604 193844 90382947
Hypovolaemic shock 19.31 13.79 22 51634 7072 90569719
Vasculitis 19.24 13.79 41 51615 22652 90554139
Carcinoid crisis 19.20 13.79 7 51649 291 90576500
Dehydration 19.15 13.79 182 51474 194265 90382526
Unevaluable event 19.05 13.79 4 51652 54844 90521947
Diarrhoea 18.93 13.79 683 50973 938507 89638284
Anxiety 18.84 13.79 264 51392 309508 90267283
Facet joint syndrome 18.80 13.79 17 51639 98372 90478419
Trichophytosis 18.72 13.79 5 51651 72 90576719
Rhabdomyolysis 18.68 13.79 68 51588 51188 90525603
Confusional state 18.46 13.79 316 51340 385889 90190902
Treatment noncompliance 18.32 13.79 68 51588 51659 90525132
Loss of personal independence in daily activities 18.16 13.79 31 51625 136074 90440717
Polymyalgia rheumatica 18.10 13.79 18 51638 4959 90571832
Crystal arthropathy 18.09 13.79 7 51649 344 90576447
Diabetic ketosis 18.08 13.79 8 51648 553 90576238
Renal tubular acidosis 18.06 13.79 13 51643 2302 90574489
Angioedema 17.97 13.79 79 51577 64797 90511994
Vulvovaginal mycotic infection 17.90 13.79 20 51636 6294 90570497
Blood ketone body increased 17.90 13.79 7 51649 354 90576437
Urethral caruncle 17.90 13.79 5 51651 86 90576705
Eyelid haematoma 17.84 13.79 5 51651 87 90576704
Blood pressure systolic decreased 17.61 13.79 24 51632 9246 90567545
Base excess decreased 17.58 13.79 5 51651 92 90576699
Muscle twitching 17.46 13.79 41 51615 24161 90552630
Abdominal discomfort 17.38 13.79 181 51475 477147 90099644
Renal failure 17.34 13.79 131 51525 130876 90445915
Diabetic hyperosmolar coma 17.27 13.79 7 51649 389 90576402
Urine ketone body present 16.93 13.79 13 51643 2539 90574252
Hepatic pain 16.91 13.79 15 51641 3580 90573211
Calculus bladder 16.82 13.79 8 51648 653 90576138
Pulmonary fibrosis 16.75 13.79 22 51634 107481 90469310
Respiratory disorder 16.71 13.79 8 51648 64808 90511983
Polydipsia 16.69 13.79 16 51640 4215 90572576
Metastasis 16.65 13.79 19 51637 6118 90570673
Injection site pruritus 16.62 13.79 5 51651 53829 90522962
Muscle neoplasm 16.59 13.79 4 51652 37 90576754
Endometrial hyperplasia 16.58 13.79 9 51647 970 90575821
Salivary hypersecretion 16.46 13.79 23 51633 9069 90567722
Gallbladder neoplasm 16.41 13.79 4 51652 39 90576752
C-reactive protein increased 16.37 13.79 51 51605 181338 90395453
Injection site reaction 16.33 13.79 17 51639 92063 90484728
Electrocardiogram T wave peaked 16.29 13.79 6 51650 257 90576534
Catheter site thrombosis 16.23 13.79 7 51649 455 90576336
Hiatus hernia 16.21 13.79 41 51615 25320 90551471
Red blood cell sedimentation rate increased 16.11 13.79 14 51642 82581 90494210
Neck pain 16.10 13.79 25 51631 113938 90462853
Bronchitis 16.03 13.79 40 51616 152887 90423904
Meningioma 16.01 13.79 17 51639 5054 90571737
Ventricular tachycardia 15.85 13.79 40 51616 24668 90552123
Acidosis 15.73 13.79 27 51629 12709 90564082
Lymphatic system neoplasm 15.73 13.79 4 51652 47 90576744
Blood glucose abnormal 15.70 13.79 23 51633 9469 90567322
Transplant rejection 15.70 13.79 27 51629 12731 90564060
Bite 15.38 13.79 7 51649 517 90576274
Metastases to ovary 15.34 13.79 7 51649 520 90576271
Pain 15.27 13.79 442 51214 995899 89580892
Genital swelling 15.17 13.79 5 51651 153 90576638
Abdominal adhesions 15.09 13.79 14 51642 3541 90573250
Hyperchylomicronaemia 15.08 13.79 4 51652 56 90576735
Micturition disorder 15.01 13.79 13 51643 3007 90573784
Back injury 15.00 13.79 4 51652 46618 90530173
Abortion spontaneous 15 13.79 6 51650 54050 90522741
Dysuria 14.98 13.79 53 51603 39348 90537443
Peptic ulcer 14.94 13.79 17 51639 5458 90571333
Myelosuppression 14.79 13.79 6 51650 53585 90523206
Blood pressure diastolic decreased 14.74 13.79 41 51615 26785 90550006
Contraindicated product prescribed 14.74 13.79 10 51646 1612 90575179
Atrial fibrillation 14.65 13.79 128 51528 133483 90443308
Thirst decreased 14.64 13.79 6 51650 343 90576448
Judgement impaired 14.62 13.79 8 51648 877 90575914
Plasmapheresis 14.57 13.79 6 51650 347 90576444
Eyelid injury 14.56 13.79 5 51651 174 90576617
Head discomfort 14.42 13.79 30 51626 16303 90560488
Therapeutic response decreased 14.36 13.79 18 51638 89711 90487080
Violence-related symptom 14.35 13.79 7 51649 604 90576187
Amnesia 14.08 13.79 108 51548 108397 90468394
Cardiogenic shock 14.04 13.79 38 51618 24430 90552361
Hypomenorrhoea 13.90 13.79 7 51649 647 90576144
Shock 13.90 13.79 42 51614 28736 90548055
Labelled drug-drug interaction issue 13.89 13.79 11 51645 2247 90574544
Diabetic neuropathy 13.86 13.79 15 51641 4559 90572232
Hyperglycaemic hyperosmolar nonketotic syndrome 13.79 13.79 9 51647 1360 90575431

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 542.15 12.40 437 37082 59417 42524399
Lactic acidosis 425.71 12.40 338 37181 44923 42538893
Acute kidney injury 423.47 12.40 969 36550 366368 42217448
Diabetic ketoacidosis 326.38 12.40 218 37301 22149 42561667
Diabetes mellitus inadequate control 309.94 12.40 184 37335 15206 42568610
Hyperkalaemia 204.60 12.40 300 37219 80158 42503658
Euglycaemic diabetic ketoacidosis 158.36 12.40 84 37435 5576 42578240
Diabetic metabolic decompensation 130.06 12.40 54 37465 2048 42581768
Hyperglycaemia 125.24 12.40 177 37342 45682 42538134
Metabolic acidosis 119.79 12.40 185 37334 51673 42532143
Glycosylated haemoglobin increased 93.39 12.40 83 37436 12841 42570975
Hypoglycaemic coma 80.38 12.40 42 37477 2702 42581114
Soft tissue mass 76.41 12.40 30 37489 982 42582834
Death 76.34 12.40 191 37328 470994 42112822
Multimorbidity 75.07 12.40 29 37490 908 42582908
Oesophageal perforation 74.01 12.40 31 37488 1202 42582614
Hyperlactacidaemia 73.09 12.40 47 37472 4469 42579347
Completed suicide 68.78 12.40 4 37515 96461 42487355
Blood glucose increased 62.70 12.40 174 37345 73525 42510291
Drug ineffective 61.68 12.40 316 37203 629881 41953935
Foetal disorder 61.01 12.40 26 37493 1053 42582763
Drug abuse 57.93 12.40 11 37508 104760 42479056
Rales 53.82 12.40 58 37461 11342 42572474
Pancreatitis acute 52.76 12.40 101 37418 33463 42550353
Neutropenia neonatal 51.46 12.40 22 37497 898 42582918
Liver palpable 50.04 12.40 16 37503 282 42583534
Type 2 diabetes mellitus 49.95 12.40 71 37448 18400 42565416
Off label use 49.75 12.40 344 37175 637991 41945825
Hepatic vein dilatation 49.72 12.40 15 37504 216 42583600
Drug interaction 49.71 12.40 403 37116 266596 42317220
Superinfection 48.47 12.40 31 37488 2920 42580896
Pemphigoid 48.37 12.40 55 37464 11412 42572404
Ketoacidosis 48.16 12.40 39 37480 5313 42578503
Disease progression 41.68 12.40 39 37480 143617 42440199
Dermatitis bullous 39.88 12.40 43 37476 8413 42575403
Transplant failure 39.66 12.40 31 37488 4013 42579803
Atrial enlargement 39.35 12.40 17 37502 712 42583104
Obstructive pancreatitis 38.78 12.40 17 37502 738 42583078
Low density lipoprotein abnormal 37.54 12.40 14 37505 397 42583419
Ureteric compression 37.46 12.40 13 37506 298 42583518
Inferior vena cava dilatation 37.43 12.40 17 37502 803 42583013
Product dose omission issue 37.01 12.40 49 37470 154316 42429500
Lower respiratory tract infection 36.73 12.40 99 37420 41107 42542709
Cardiac failure 36.37 12.40 188 37331 106668 42477148
Myocardial ischaemia 36.35 12.40 60 37459 17702 42566114
Immunosuppressant drug level increased 35.91 12.40 39 37480 7692 42576124
Obesity 35.59 12.40 57 37462 16402 42567414
Malaise 34.57 12.40 311 37208 211845 42371971
Lumbosacral radiculoplexus neuropathy 33.48 12.40 9 37510 83 42583733
Platelet count decreased 33.20 12.40 44 37475 138537 42445279
Skin ulcer 33.04 12.40 71 37448 25530 42558286
Inflammatory marker increased 32.99 12.40 35 37484 6721 42577095
Varicella zoster pneumonia 31.75 12.40 11 37508 251 42583565
Right ventricular dysfunction 31.39 12.40 18 37501 1391 42582425
Fibrillary glomerulonephritis 31.34 12.40 8 37511 59 42583757
Helicobacter test false negative 30.77 12.40 8 37511 64 42583752
Hepatojugular reflux 30.75 12.40 14 37505 665 42583151
Ventricular enlargement 30.67 12.40 14 37505 669 42583147
Lung consolidation 29.82 12.40 33 37486 6644 42577172
Weight increased 29.44 12.40 179 37340 107804 42476012
Cardiac failure chronic 29.10 12.40 39 37480 9562 42574254
Blood pressure increased 29.09 12.40 171 37348 101757 42482059
Thrombosis 28.97 12.40 12 37507 68499 42515317
Oesophageal carcinoma 28.80 12.40 39 37480 9657 42574159
Spleen congestion 28.43 12.40 11 37508 346 42583470
Dyspnoea at rest 28.16 12.40 26 37493 4223 42579593
Infection parasitic 26.77 12.40 11 37508 406 42583410
Neuromyopathy 26.65 12.40 15 37504 1119 42582697
Urinary tract discomfort 26.40 12.40 8 37511 117 42583699
Flour sensitivity 26.39 12.40 6 37513 25 42583791
Pancreatic carcinoma 26.38 12.40 37 37482 9469 42574347
Mouth swelling 25.97 12.40 19 37500 2227 42581589
Potentiating drug interaction 25.56 12.40 30 37489 6438 42577378
Pain 25.38 12.40 120 37399 244728 42339088
Microsporum infection 25.33 12.40 6 37513 31 42583785
Onychoclasis 25.30 12.40 20 37499 2632 42581184
Dental caries 25.15 12.40 26 37493 4846 42578970
Product use in unapproved indication 25.13 12.40 81 37438 184375 42399441
Ketonuria 24.85 12.40 12 37507 652 42583164
Cardiomegaly 24.57 12.40 49 37470 16717 42567099
White blood cell count decreased 24.50 12.40 37 37482 110359 42473457
Spondylolysis 24.37 12.40 7 37512 84 42583732
Pancreatic carcinoma metastatic 24.20 12.40 21 37498 3145 42580671
Tonic clonic movements 24.05 12.40 15 37504 1352 42582464
Hypovolaemia 23.77 12.40 39 37480 11446 42572370
Sopor 23.60 12.40 42 37477 13160 42570656
Renal impairment 23.57 12.40 172 37347 110056 42473760
Tongue haemorrhage 23.45 12.40 12 37507 739 42583077
Autoimmune pancreatitis 23.37 12.40 10 37509 409 42583407
Acute painful neuropathy of rapid glycaemic control 23.26 12.40 5 37514 15 42583801
Melaena 23.20 12.40 81 37438 38665 42545151
Herbal interaction 23.17 12.40 10 37509 418 42583398
Therapy non-responder 23.12 12.40 9 37510 53350 42530466
Adrenal cyst 22.87 12.40 8 37511 188 42583628
Cholestasis 22.58 12.40 72 37447 32807 42551009
Drug level increased 22.39 12.40 62 37457 26138 42557678
Hyperglycaemic hyperosmolar nonketotic syndrome 21.74 12.40 15 37504 1603 42582213
Peak expiratory flow rate decreased 21.60 12.40 7 37512 129 42583687
Hypohidrosis 21.52 12.40 8 37511 225 42583591
Intentional product misuse 21.49 12.40 14 37505 61886 42521930
Intercapillary glomerulosclerosis 21.45 12.40 6 37513 65 42583751
Food aversion 21.28 12.40 10 37509 511 42583305
Pyonephrosis 21.21 12.40 7 37512 137 42583679
Aspartate aminotransferase increased 21.15 12.40 22 37497 77141 42506675
Blood pressure diastolic increased 20.93 12.40 27 37492 6378 42577438
Substance use 20.67 12.40 15 37504 1736 42582080
Hypoosmolar state 20.66 12.40 7 37512 149 42583667
Blood pressure fluctuation 20.41 12.40 61 37458 26847 42556969
Bronchitis viral 20.20 12.40 8 37511 268 42583548
Haematoma muscle 20.05 12.40 16 37503 2134 42581682
Anal fistula 20.01 12.40 26 37493 6187 42577629
Distributive shock 19.98 12.40 17 37502 2479 42581337
Cardiac ventricular disorder 19.90 12.40 8 37511 279 42583537
Asthma-chronic obstructive pulmonary disease overlap syndrome 19.89 12.40 14 37505 1545 42582271
Neutrophil count decreased 19.85 12.40 16 37503 63399 42520417
Cockroach allergy 19.34 12.40 5 37514 39 42583777
Microalbuminuria 19.03 12.40 11 37508 863 42582953
Hemiparaesthesia 18.99 12.40 7 37512 192 42583624
Bursitis infective 18.93 12.40 10 37509 658 42583158
Depression 18.82 12.40 44 37475 111319 42472497
Pyelocaliectasis 18.79 12.40 13 37506 1396 42582420
Cytomegalovirus infection 18.70 12.40 3 37516 32303 42551513
Gastrointestinal bacterial infection 18.61 12.40 10 37509 681 42583135
Capillary fragility 18.33 12.40 5 37514 49 42583767
Respiratory rate increased 18.26 12.40 34 37485 11028 42572788
Application site haematoma 18.24 12.40 5 37514 50 42583766
Blood pressure abnormal 18.12 12.40 32 37487 9966 42573850
Dry skin 18.08 12.40 10 37509 48328 42535488
Blood pressure systolic increased 18.08 12.40 60 37459 27908 42555908
Neutrophilia 17.71 12.40 23 37496 5469 42578347
Left ventricular dysfunction 17.32 12.40 34 37485 11467 42572349
Acetonaemia 17.15 12.40 7 37512 254 42583562
Genital swelling 17.07 12.40 7 37512 257 42583559
Productive cough 17.02 12.40 90 37429 51477 42532339
Jaundice cholestatic 16.94 12.40 22 37497 5231 42578585
Mast cell degranulation present 16.84 12.40 5 37514 68 42583748
Metastases to pelvis 16.82 12.40 8 37511 420 42583396
Heart rate irregular 16.82 12.40 41 37478 16009 42567807
Mental status changes 16.82 12.40 8 37511 42107 42541709
Glycosuria 16.78 12.40 12 37507 1358 42582458
Neutropenia 16.65 12.40 105 37414 199326 42384490
Drug ineffective for unapproved indication 16.63 12.40 10 37509 46153 42537663
Wrong patient received product 16.51 12.40 18 37501 3565 42580251
Seizure 16.37 12.40 53 37466 120508 42463308
Diabetic neuropathy 16.34 12.40 20 37499 4482 42579334
Stenosis 16.19 12.40 14 37505 2087 42581729
Plasma cell myeloma 16.19 12.40 11 37508 47567 42536249
Exercise tolerance decreased 15.93 12.40 23 37496 6043 42577773
Orbital oedema 15.90 12.40 6 37513 176 42583640
Forced vital capacity decreased 15.75 12.40 10 37509 930 42582886
Nephritis 15.68 12.40 18 37501 3771 42580045
Staphylococcal infection 15.26 12.40 7 37512 37636 42546180
Pyelonephritis 15.21 12.40 26 37493 7888 42575928
Adverse drug reaction 15.12 12.40 7 37512 37427 42546389
Basosquamous carcinoma 15.09 12.40 5 37514 99 42583717
Pancreatitis chronic 15.09 12.40 14 37505 2288 42581528
Oxygen saturation decreased 15.02 12.40 103 37416 64584 42519232
Vitamin D deficiency 14.84 12.40 26 37493 8047 42575769
Conjunctival disorder 14.82 12.40 5 37514 105 42583711
Pyroglutamic acidosis 14.79 12.40 9 37510 776 42583040
Blood glucose abnormal 14.66 12.40 24 37495 7029 42576787
Necrotising fasciitis 14.60 12.40 19 37500 4527 42579289
Blood pressure systolic abnormal 14.58 12.40 21 37498 5507 42578309
Suspected suicide attempt 14.57 12.40 7 37512 376 42583440
Ocular myasthenia 14.56 12.40 8 37511 569 42583247
Hospitalisation 14.55 12.40 27 37492 74303 42509513
Gastric dilatation 14.50 12.40 9 37510 804 42583012
Heart rate 14.50 12.40 4 37515 41 42583775
Unevaluable event 14.50 12.40 6 37513 34282 42549534
Hyperintensity in brain deep nuclei 14.47 12.40 5 37514 113 42583703
Diabetic retinopathy 14.41 12.40 13 37506 2050 42581766
Urine ketone body present 14.35 12.40 11 37508 1383 42582433
Restlessness 14.31 12.40 4 37515 29245 42554571
Anion gap increased 14.24 12.40 13 37506 2081 42581735
Bradycardia 14.23 12.40 126 37393 85358 42498458
Hyperaesthesia teeth 14.12 12.40 8 37511 604 42583212
Bite 14.08 12.40 5 37514 123 42583693
Medical device implantation 14.01 12.40 8 37511 613 42583203
Immune-mediated myositis 14.01 12.40 17 37502 3776 42580040
Chorioretinitis 13.90 12.40 8 37511 623 42583193
Irregular sleep phase 13.89 12.40 5 37514 128 42583688
Pyrexia 13.84 12.40 254 37265 393788 42190028
Generalised oedema 13.81 12.40 37 37482 15299 42568517
Complex regional pain syndrome 13.73 12.40 8 37511 637 42583179
Fatigue 13.73 12.40 286 37233 435355 42148461
Cardiorenal syndrome 13.73 12.40 9 37510 884 42582932
Ketosis 13.62 12.40 9 37510 896 42582920
Renal failure 13.43 12.40 189 37330 143537 42440279
Face oedema 13.36 12.40 34 37485 13632 42570184
Mycobacterial infection 13.34 12.40 14 37505 2654 42581162
Electrolyte depletion 13.30 12.40 6 37513 279 42583537
Lipase increased 13.28 12.40 29 37490 10537 42573279
Gastric varices 13.23 12.40 8 37511 682 42583134
Ventricular fibrillation 13.18 12.40 5 37514 30118 42553698
Latent autoimmune diabetes in adults 13.18 12.40 5 37514 149 42583667
Traumatic shock 13.10 12.40 3 37516 13 42583803
Ejection fraction decreased 13.07 12.40 46 37473 22041 42561775
Pancreatic neoplasm 13.02 12.40 9 37510 965 42582851
Blood glucose fluctuation 12.94 12.40 18 37501 4569 42579247
Polyp 12.86 12.40 18 37501 4596 42579220
Lipid metabolism disorder 12.85 12.40 7 37512 490 42583326
Decreased appetite 12.82 12.40 240 37279 192897 42390919
Incarcerated hernia 12.81 12.40 5 37514 161 42583655
Loss of personal independence in daily activities 12.77 12.40 15 37504 49801 42534015

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1305.08 11.80 920 85585 115184 110387610
Lactic acidosis 1164.20 11.80 787 85718 92024 110410770
Acute kidney injury 867.54 11.80 1677 84828 633753 109869041
Diabetes mellitus inadequate control 738.78 11.80 392 86113 29383 110473411
Diabetic ketoacidosis 617.93 11.80 394 86111 41664 110461130
Hyperkalaemia 476.70 11.80 559 85946 135237 110367557
Hyperglycaemia 338.69 11.80 374 86131 84716 110418078
Euglycaemic diabetic ketoacidosis 331.23 11.80 168 86337 11455 110491339
Gangrene 314.33 11.80 182 86323 16159 110486635
Arterial occlusive disease 301.13 11.80 173 86332 15135 110487659
Carotid artery thrombosis 288.41 11.80 144 86361 9494 110493300
Neurologic neglect syndrome 287.35 11.80 142 86363 9156 110493638
Adjustment disorder 261.69 11.80 140 86365 10655 110492139
Metabolic acidosis 256.80 11.80 352 86153 99392 110403402
Personality disorder 254.98 11.80 146 86359 12691 110490103
Motor dysfunction 245.36 11.80 181 86324 24225 110478569
Diabetic metabolic decompensation 228.16 11.80 93 86412 3796 110498998
Sensory loss 222.19 11.80 162 86343 21295 110481499
Hypoglycaemic coma 218.39 11.80 100 86405 5433 110497361
Skin haemorrhage 216.20 11.80 169 86336 24658 110478136
Glycosylated haemoglobin increased 210.50 11.80 163 86342 23456 110479338
Affect lability 209.70 11.80 148 86357 18489 110484305
Sinus congestion 188.01 11.80 170 86335 30289 110472505
Hemiplegia 185.34 11.80 149 86356 22633 110480161
Coordination abnormal 178.15 11.80 152 86353 25076 110477718
Sneezing 171.38 11.80 165 86340 31819 110470975
Eating disorder 170.67 11.80 162 86343 30696 110472098
Cataract 164.46 11.80 253 86252 79232 110423562
Blood glucose increased 164.33 11.80 337 86168 132159 110370635
Respiratory tract congestion 161.22 11.80 157 86348 30700 110472094
Angina pectoris 159.01 11.80 219 86286 62076 110440718
Blood pressure increased 158.27 11.80 503 86002 257870 110244924
Maternal exposure during pregnancy 156.71 11.80 11 86494 254872 110247922
Glossodynia 154.74 11.80 4 86501 222000 110280794
Arthropathy 154.35 11.80 21 86484 287501 110215293
Completed suicide 153.36 11.80 9 86496 242372 110260422
Sinus disorder 146.23 11.80 153 86352 32575 110470219
Hemiparesis 142.80 11.80 174 86331 43729 110459065
Ketoacidosis 141.90 11.80 92 86413 9995 110492799
Aphasia 139.58 11.80 200 86305 58797 110443997
Synovitis 138.06 11.80 24 86481 274068 110228726
Multiple drug therapy 132.57 11.80 81 86424 7933 110494861
Hyperlactacidaemia 130.08 11.80 81 86424 8205 110494589
Pemphigus 129.78 11.80 10 86495 214560 110288234
Pemphigoid 129.57 11.80 114 86391 19593 110483201
Pancreatitis acute 127.70 11.80 194 86311 60080 110442714
Helicobacter infection 124.09 11.80 4 86501 181873 110320921
Folliculitis 116.90 11.80 3 86502 167650 110335144
Muscle spasticity 116.25 11.80 142 86363 35773 110467021
Stomatitis 115.44 11.80 34 86471 270208 110232586
Loss of employment 115.15 11.80 55 86450 3289 110499505
Malignant mediastinal neoplasm 112.92 11.80 42 86463 1336 110501458
Drug interaction 111.62 11.80 721 85784 499462 110003332
Cystitis 109.23 11.80 190 86315 65846 110436948
Rhinorrhoea 108.74 11.80 245 86260 102421 110400373
Wound 108.71 11.80 25 86480 234412 110268382
Palpitations 107.69 11.80 321 86184 158891 110343903
Hyponatraemia 107.14 11.80 394 86111 217259 110285535
Cardiac failure 105.58 11.80 355 86150 187271 110315523
Influenza like illness 102.73 11.80 219 86286 88193 110414601
Injury 102.46 11.80 10 86495 177255 110325539
Infusion related reaction 101.81 11.80 89 86416 381073 110121721
Exposure during pregnancy 100.69 11.80 8 86497 167416 110335378
Malaise 97.35 11.80 875 85630 670944 109831850
Fibromyalgia 95.30 11.80 11 86494 170898 110331896
Melaena 94.97 11.80 183 86322 68574 110434220
Drug ineffective 94.68 11.80 750 85755 1519790 108983004
Irritable bowel syndrome 93.00 11.80 10 86495 164205 110338589
Impaired healing 91.15 11.80 21 86484 196696 110306098
Death 90.97 11.80 264 86241 698605 109804189
Treatment failure 90.76 11.80 52 86453 277182 110225612
Dysarthria 90.48 11.80 202 86303 83919 110418875
Blood pressure inadequately controlled 89.09 11.80 62 86443 7571 110495223
Hand deformity 88.84 11.80 30 86475 218476 110284318
Exercise tolerance decreased 83.75 11.80 72 86433 11995 110490799
Product use in unapproved indication 81.94 11.80 140 86365 447237 110055557
Muscle injury 81.22 11.80 8 86497 140799 110361995
Blood cholesterol decreased 79.55 11.80 40 86465 2676 110500118
Blood cholesterol increased 75.76 11.80 25 86480 184760 110318034
Skin exfoliation 75.40 11.80 193 86312 87458 110415336
Hepatic steatosis 74.96 11.80 136 86369 48695 110454099
Therapy non-responder 74.48 11.80 16 86489 157291 110345503
Chest discomfort 74.30 11.80 301 86204 173547 110329247
Psoriatic arthropathy 71.74 11.80 32 86473 196729 110306065
Discomfort 70.65 11.80 40 86465 214667 110288127
Drug abuse 69.30 11.80 26 86479 177385 110325409
Alopecia 68.76 11.80 112 86393 364641 110138153
Product dose omission issue 67.26 11.80 92 86413 321690 110181104
Swelling 65.97 11.80 108 86397 350933 110151861
Blister 65.79 11.80 49 86456 227327 110275467
Oesophageal perforation 65.52 11.80 30 86475 1629 110501165
Hepatic enzyme increased 64.83 11.80 94 86411 320798 110181996
Soft tissue mass 64.59 11.80 29 86476 1504 110501290
Dysphagia 64.09 11.80 264 86241 153336 110349458
Hypersensitivity 63.86 11.80 138 86367 403860 110098934
Pericarditis 63.68 11.80 47 86458 219067 110283727
Blood immunoglobulin E increased 63.12 11.80 50 86455 7432 110495362
Ill-defined disorder 62.94 11.80 22 86483 156831 110345963
Psoriasis 62.72 11.80 246 86259 139747 110363047
Condition aggravated 62.58 11.80 329 86176 734507 109768287
Pancreatic carcinoma 61.96 11.80 67 86438 14805 110487989
Multimorbidity 61.65 11.80 28 86477 1492 110501302
Off label use 61.39 11.80 817 85688 1499368 109003426
Atrioventricular block first degree 59.11 11.80 64 86441 14161 110488633
Infection 57.84 11.80 123 86382 362077 110140717
Peripheral circulatory failure 56.85 11.80 28 86477 1791 110501003
Urinary retention 56.41 11.80 150 86355 69533 110433261
Neuroglycopenia 56.20 11.80 24 86481 1102 110501692
Fall 55.10 11.80 717 85788 602765 109900029
Rheumatic fever 54.99 11.80 14 86491 122565 110380229
Urticaria 52.83 11.80 106 86399 318751 110184043
Disease progression 51.76 11.80 69 86436 243965 110258829
Joint swelling 51.40 11.80 176 86329 442669 110060125
Hepatic vein dilatation 50.66 11.80 15 86490 229 110502565
Liver palpable 49.32 11.80 16 86489 335 110502459
C-reactive protein abnormal 49.01 11.80 20 86485 129675 110373119
White blood cell count decreased 48.51 11.80 65 86440 229325 110273469
Cough 48.38 11.80 563 85942 461078 110041716
Muscular weakness 48.04 11.80 346 86159 248122 110254672
Adverse event 47.72 11.80 13 86492 108796 110393998
Lower limb fracture 47.02 11.80 3 86502 75345 110427449
Neutropenia 46.86 11.80 144 86361 374476 110128318
General physical health deterioration 46.05 11.80 174 86331 425121 110077673
Wound infection 45.27 11.80 10 86495 96455 110406339
Parkinsonism 44.99 11.80 70 86435 22117 110480677
Drug hypersensitivity 44.62 11.80 193 86312 453897 110048897
Joint range of motion decreased 44.11 11.80 20 86485 121812 110380982
Upper respiratory tract infection 43.87 11.80 24 86481 131304 110371490
Cerebrovascular accident 43.85 11.80 267 86238 181017 110321777
Aspartate aminotransferase increased 43.08 11.80 37 86468 159899 110342895
Gastric disorder 42.69 11.80 86 86419 33271 110469523
Hypoaesthesia 42.04 11.80 117 86388 314106 110188688
Drug ineffective for unapproved indication 41.99 11.80 14 86491 102824 110399970
Inflammatory marker increased 41.71 11.80 54 86451 14415 110488379
Road traffic accident 41.50 11.80 16 86489 107382 110395412
Obstructive pancreatitis 41.48 11.80 20 86485 1221 110501573
Dermatitis bullous 40.82 11.80 59 86446 17470 110485324
Gastric polyps 40.47 11.80 34 86471 5489 110497305
Vomiting 40.05 11.80 963 85542 909712 109593082
Knee arthroplasty 39.33 11.80 3 86502 64945 110437849
Ureteric compression 38.84 11.80 13 86492 301 110502493
Acetonaemia 38.31 11.80 15 86490 550 110502244
Grip strength decreased 38.26 11.80 8 86497 80166 110422628
Sleep disorder 37.40 11.80 61 86444 198583 110304211
Adverse drug reaction 37.18 11.80 18 86487 105541 110397253
Cognitive disorder 36.95 11.80 151 86354 87360 110415434
Atrial enlargement 36.82 11.80 18 86487 1133 110501661
Initial insomnia 36.78 11.80 43 86462 10346 110492448
Liver injury 36.75 11.80 38 86467 150375 110352419
Inferior vena cava dilatation 36.67 11.80 17 86488 950 110501844
Dermatitis artefacta 35.67 11.80 9 86496 72 110502722
Renal impairment 35.60 11.80 261 86244 188184 110314610
Pruritus genital 35.60 11.80 34 86471 6488 110496306
Mental status changes 35.50 11.80 8 86497 76114 110426680
Lip dry 35.35 11.80 17 86488 100066 110402728
Superinfection 35.23 11.80 32 86473 5731 110497063
Low density lipoprotein abnormal 34.82 11.80 14 86491 551 110502243
Blood glucose fluctuation 34.40 11.80 36 86469 7662 110495132
Prescribed underdose 34.38 11.80 5 86500 65169 110437625
Product quality issue 34.34 11.80 9 86496 77290 110425504
Sleep disorder due to general medical condition, insomnia type 34.28 11.80 20 86485 105623 110397171
Therapeutic product effect decreased 34.16 11.80 89 86416 244227 110258567
Medication error 34.10 11.80 168 86337 105198 110397596
Cholestatic liver injury 33.87 11.80 35 86470 7341 110495453
Facet joint syndrome 33.36 11.80 17 86488 96811 110405983
Myelosuppression 33.36 11.80 16 86489 94324 110408470
Urine ketone body present 33.09 11.80 26 86479 3820 110498974
Rash 32.72 11.80 449 86056 820515 109682279
Blood pressure systolic increased 32.54 11.80 140 86365 82851 110419943
Pain 32.35 11.80 539 85966 954416 109548378
Blood glucose abnormal 32.33 11.80 45 86460 12871 110489923
Inflammation 32.20 11.80 64 86441 193174 110309620
Renal failure 32.11 11.80 294 86211 226280 110276514
Bradycardia 32.05 11.80 220 86285 155297 110347497
Transplant failure 31.95 11.80 30 86475 5605 110497189
Lumbosacral radiculoplexus neuropathy 31.94 11.80 9 86496 114 110502680
Dementia 31.76 11.80 74 86431 31599 110471195
Helicobacter test false negative 31.71 11.80 8 86497 64 110502730
Ventricular enlargement 31.47 11.80 14 86491 710 110502084
Platelet count decreased 31.41 11.80 85 86420 230358 110272436
Butterfly rash 31.36 11.80 20 86485 2111 110500683
Neutrophil count decreased 31.34 11.80 29 86476 120912 110381882
Hepatojugular reflux 31.27 11.80 14 86491 721 110502073
Cardiospasm 31.19 11.80 28 86477 4939 110497855
Migraine 31.12 11.80 54 86451 171598 110331196
Genital swelling 31.10 11.80 12 86493 423 110502371
Fibrillary glomerulonephritis 31.07 11.80 8 86497 70 110502724
Pneumonia aspiration 31.06 11.80 136 86369 81097 110421697
Rales 30.73 11.80 63 86442 24676 110478118
Cardiomegaly 30.25 11.80 69 86436 29061 110473733
Loss of personal independence in daily activities 30.22 11.80 44 86461 149976 110352818
Vulvovaginal candidiasis 29.98 11.80 23 86482 3262 110499532
Anaemia vitamin B12 deficiency 29.98 11.80 16 86489 1211 110501583
Diabetic neuropathy 29.98 11.80 32 86473 6967 110495827
Glycosuria 29.85 11.80 21 86484 2609 110500185
Bacterial translocation 29.71 11.80 17 86488 1475 110501319
Hyperglycaemic hyperosmolar nonketotic syndrome 29.53 11.80 22 86483 2987 110499807
Diarrhoea 29.52 11.80 1129 85376 1138376 109364418
Prescribed overdose 29.25 11.80 16 86489 87565 110415229
Palmoplantar keratoderma 29.25 11.80 28 86477 5359 110497435
Drug level increased 29.24 11.80 93 86412 47626 110455168
Pancreatic carcinoma metastatic 29.21 11.80 25 86480 4139 110498655
Tubulointerstitial nephritis 29.00 11.80 101 86404 54183 110448611
Blood glucose decreased 28.60 11.80 68 86437 29420 110473374
Myocardial ischaemia 28.59 11.80 64 86441 26620 110476174
Polymyalgia rheumatica 28.56 11.80 30 86475 6412 110496382
Gait inability 28.46 11.80 39 86466 136337 110366457
Autoimmune disorder 28.38 11.80 8 86497 65475 110437319
Night sweats 28.28 11.80 38 86467 133945 110368849
Red blood cell sedimentation rate increased 28.11 11.80 13 86492 78289 110424505
Varicella zoster pneumonia 28.10 11.80 11 86494 403 110502391
Immunosuppressant drug level increased 28.09 11.80 40 86465 11684 110491110
Unevaluable event 28.07 11.80 6 86499 59221 110443573
Alopecia scarring 27.76 11.80 9 86496 188 110502606
Wrong patient received product 27.68 11.80 30 86475 6644 110496150
Glucose urine present 27.67 11.80 19 86486 2270 110500524
Gastrointestinal disorder 27.53 11.80 300 86205 241652 110261142
Inappropriate antidiuretic hormone secretion 27.52 11.80 73 86432 33778 110469016
Sleep disorder due to a general medical condition 27.49 11.80 4 86501 52108 110450686
Mesenteric panniculitis 27.37 11.80 12 86493 588 110502206
Injection site reaction 27.33 11.80 18 86487 89052 110413742
Stupor 27.26 11.80 33 86472 8232 110494562
Metastases to fallopian tube 27.21 11.80 7 86498 61 110502733
Cardiac failure chronic 27.21 11.80 43 86462 13768 110489026
Nail disorder 27.20 11.80 6 86499 57929 110444865
Diabetes mellitus 27.02 11.80 151 86354 99230 110403564
No adverse event 26.91 11.80 12 86493 73827 110428967
Bite 26.90 11.80 12 86493 613 110502181
Injection site pruritus 26.88 11.80 4 86501 51254 110451540
Cardioactive drug level increased 26.61 11.80 23 86482 3859 110498935
Hypotension 26.41 11.80 565 85940 523284 109979510
Tension headache 26.33 11.80 35 86470 9583 110493211
Bursitis 26.27 11.80 38 86467 129880 110372914
Coma 26.25 11.80 170 86335 117699 110385095
Multiple sclerosis relapse 26.17 11.80 4 86501 50236 110452558
Spleen congestion 26.12 11.80 11 86494 488 110502306
Pain of skin 26.06 11.80 52 86453 19977 110482817
Accidental exposure to product 26.00 11.80 4 86501 50004 110452790
Neutrophilia 25.88 11.80 36 86469 10293 110492501
Bone erosion 25.80 11.80 3 86502 46368 110456426
Influenza 25.79 11.80 223 86282 168878 110333916
Hip arthroplasty 25.76 11.80 6 86499 55807 110446987
Depressed mood 25.73 11.80 105 86400 60704 110442090
Oesophageal carcinoma 25.69 11.80 38 86467 11486 110491308
Faeces discoloured 25.39 11.80 71 86434 33877 110468917
Adrenal cyst 25.21 11.80 9 86496 254 110502540
Injection site erythema 25.10 11.80 22 86483 94154 110408640
Renal tubular disorder 25.06 11.80 30 86475 7399 110495395
Muscle rigidity 25.04 11.80 57 86448 23974 110478820
Ketonuria 25.01 11.80 15 86490 1420 110501374
Acne 24.97 11.80 70 86435 33450 110469344
Head injury 24.70 11.80 82 86423 42935 110459859
Therapeutic product effect incomplete 24.57 11.80 91 86414 223714 110279080
Pregnancy 24.56 11.80 5 86500 51062 110451732
Sleep terror 24.47 11.80 28 86477 6582 110496212
Neuromyopathy 24.47 11.80 16 86489 1763 110501031
Lip swelling 24.29 11.80 91 86414 50576 110452218
Wheezing 24.13 11.80 110 86395 255120 110247674
Microsporum infection 24.12 11.80 6 86499 45 110502749
Thrombocytosis 24.10 11.80 35 86470 10409 110492385
Acidosis 24.10 11.80 54 86451 22477 110480317
Pyonephrosis 23.91 11.80 8 86497 185 110502609
Hypomagnesaemia 23.79 11.80 102 86403 60268 110442526
Thrombosis 23.77 11.80 30 86475 108632 110394162
Depression 23.23 11.80 149 86356 317186 110185608
Peripheral venous disease 23.21 11.80 19 86486 84098 110418696
Exostosis 23.17 11.80 4 86501 45952 110456842
Pyelocaliectasis 22.95 11.80 13 86492 1106 110501688
Dehydration 22.94 11.80 326 86179 279185 110223609
Joint noise 22.89 11.80 24 86481 5119 110497675
Flour sensitivity 22.74 11.80 5 86500 20 110502774
Potentiating drug interaction 22.59 11.80 36 86469 11607 110491187
Fear-related avoidance of activities 22.41 11.80 7 86498 129 110502665
Diabetic ketosis 22.29 11.80 12 86493 924 110501870
Dyspnoea at rest 22.28 11.80 30 86475 8316 110494478
Diabetic retinopathy 22.20 11.80 20 86485 3544 110499250
Back injury 22.07 11.80 5 86500 47394 110455400
Blood pressure fluctuation 21.90 11.80 116 86389 74708 110428086
Periorbital oedema 21.85 11.80 33 86472 10159 110492635
Chorea 21.84 11.80 19 86486 3216 110499578
Bradykinesia 21.82 11.80 34 86471 10754 110492040
Microalbuminuria 21.63 11.80 13 86492 1236 110501558
Necrotising fasciitis 21.37 11.80 28 86477 7563 110495231
Bronchitis 21.34 11.80 58 86447 156974 110345820
Lung consolidation 21.17 11.80 33 86472 10443 110492351
Rebound psychosis 21.16 11.80 9 86496 409 110502385
Polydipsia 21.09 11.80 28 86477 7660 110495134
Acute painful neuropathy of rapid glycaemic control 21.07 11.80 5 86500 30 110502764
Insulin-like growth factor decreased 20.86 11.80 10 86495 603 110502191
Open reduction of fracture 20.84 11.80 8 86497 278 110502516
Drug resistance 20.80 11.80 9 86496 56365 110446429
Herbal interaction 20.66 11.80 10 86495 616 110502178
Blood potassium increased 20.56 11.80 65 86440 33184 110469610
Muscle atrophy 20.44 11.80 37 86468 13217 110489577
Respiratory arrest 20.44 11.80 10 86495 58289 110444505
Lipase increased 20.25 11.80 45 86460 18627 110484167
Atrial tachycardia 20.08 11.80 30 86475 9148 110493646
Infection parasitic 20.01 11.80 11 86494 883 110501911
Endometrial cancer stage I 20.01 11.80 7 86498 186 110502608
Acute coronary syndrome 19.98 11.80 51 86454 23061 110479733
Hypohidrosis 19.82 11.80 8 86497 318 110502476
Tongue haemorrhage 19.47 11.80 12 86493 1193 110501601
Right ventricular dysfunction 19.43 11.80 18 86487 3305 110499489
Syncope 19.42 11.80 243 86262 202293 110300501
Transplant dysfunction 19.35 11.80 28 86477 8300 110494494
Alanine aminotransferase increased 19.34 11.80 76 86429 183697 110319097
Meningioma 19.31 11.80 23 86482 5642 110497152
Pseudohallucination 19.27 11.80 7 86498 208 110502586
Cardiac ventricular disorder 19.25 11.80 8 86497 343 110502451
Upper gastrointestinal haemorrhage 19.25 11.80 84 86421 50012 110452782
Arthritis 19.15 11.80 208 86297 167378 110335416
Intercapillary glomerulosclerosis 19.09 11.80 6 86499 113 110502681
Mouth swelling 18.98 11.80 26 86479 7328 110495466
Cockroach allergy 18.94 11.80 6 86499 116 110502678
Intentional product misuse 18.88 11.80 48 86457 132856 110369938
Seizure 18.78 11.80 99 86406 221086 110281708
Spondylolysis 18.72 11.80 7 86498 226 110502568
Dermatitis exfoliative generalised 18.70 11.80 32 86473 10940 110491854
Diabetic nephropathy 18.60 11.80 18 86487 3490 110499304
Respiratory rate increased 18.31 11.80 52 86453 25031 110477763
Steatorrhoea 18.26 11.80 11 86494 1050 110501744
Infected dermal cyst 18.24 11.80 12 86493 1336 110501458
Carcinoid tumour 18.12 11.80 9 86496 586 110502208
Dysuria 18.06 11.80 94 86411 60137 110442657
Rhabdomyolysis 17.95 11.80 158 86347 120243 110382551
Crystal arthropathy 17.87 11.80 7 86498 257 110502537
Cortisol decreased 17.83 11.80 16 86489 2820 110499974
Autoimmune pancreatitis 17.82 11.80 10 86495 836 110501958
Therapeutic response decreased 17.81 11.80 30 86475 96469 110406325
Onychoclasis 17.80 11.80 25 86480 7212 110495582
Toxicity to various agents 17.64 11.80 267 86238 480288 110022506
Blood pressure systolic decreased 17.61 11.80 35 86470 13406 110489388
Head discomfort 17.55 11.80 43 86462 18957 110483837
Urine calcium/creatinine ratio increased 17.53 11.80 6 86499 149 110502645
Cholestasis 17.52 11.80 98 86407 64420 110438374
Dry eye 17.49 11.80 11 86494 55782 110447012
Mast cell degranulation present 17.42 11.80 5 86500 68 110502726
Blood ketone body increased 17.37 11.80 10 86495 878 110501916
Urine output decreased 17.33 11.80 44 86461 19832 110482962
Urethral caruncle 17.22 11.80 5 86500 71 110502723
Pancreatic neoplasm 17.12 11.80 13 86492 1816 110500978
Bronchiectasis 17.04 11.80 65 86440 36428 110466366
Posterior reversible encephalopathy syndrome 16.96 11.80 3 86502 33858 110468936
Blood lactic acid 16.88 11.80 8 86497 470 110502324
Osteonecrosis 16.87 11.80 3 86502 33738 110469056
Application site haematoma 16.79 11.80 5 86500 78 110502716
Endometrial hyperplasia 16.72 11.80 9 86496 693 110502101
Carotid artery occlusion 16.44 11.80 28 86477 9537 110493257
Plasma cell myeloma 16.41 11.80 15 86490 62921 110439873
Respiratory disorder 16.36 11.80 19 86486 71363 110431431
Blood creatine increased 16.31 11.80 31 86474 11490 110491304
Pyelonephritis 16.20 11.80 50 86455 25200 110477594
Neoplasm skin 16.17 11.80 16 86489 3188 110499606
Immune-mediated myositis 16.16 11.80 22 86483 6164 110496630
Metastases to bladder 16.10 11.80 7 86498 336 110502458
Erectile dysfunction 16.09 11.80 41 86464 18515 110484279
Hypotonia 16.02 11.80 37 86468 15708 110487086
Food aversion 16.02 11.80 12 86493 1643 110501151
Hypovolaemia 15.89 11.80 45 86460 21629 110481165
Intentional product use issue 15.88 11.80 121 86384 247785 110255009
Coeliac disease 15.77 11.80 7 86498 43180 110459614
Full blood count decreased 15.74 11.80 3 86502 32096 110470698
Suspected suicide attempt 15.70 11.80 7 86498 357 110502437
Autoimmune nephritis 15.58 11.80 9 86496 795 110501999
Substance use 15.49 11.80 14 86491 2492 110500302
Vulvovaginal mycotic infection 15.39 11.80 20 86485 5357 110497437
Nausea 15.38 11.80 1143 85362 1234547 109268247
Tonic clonic movements 15.38 11.80 15 86490 2937 110499857
Serum serotonin increased 15.38 11.80 7 86498 375 110502419
Haemophagocytic lymphohistiocytosis 15.37 11.80 3 86502 31556 110471238
Nocturia 15.22 11.80 38 86467 16952 110485842
Hypercholesterolaemia 15.20 11.80 30 86475 90807 110411987
Metastases to ovary 15.07 11.80 7 86498 393 110502401
Fluid retention 15.05 11.80 32 86473 94275 110408519
Gait disturbance 15.03 11.80 142 86363 278066 110224728
Fatigue 15.02 11.80 788 85717 1215170 109287624
Basosquamous carcinoma 14.97 11.80 5 86500 115 110502679
Hemiparaesthesia 14.94 11.80 7 86498 401 110502393
Febrile neutropenia 14.93 11.80 167 86338 316600 110186194
Treatment noncompliance 14.88 11.80 103 86402 72887 110429907
Eyelid haematoma 14.81 11.80 5 86500 119 110502675
Cytokine release syndrome 14.77 11.80 20 86485 70286 110432508
Hypoosmolar state 14.76 11.80 7 86498 412 110502382
Premature delivery 14.73 11.80 3 86502 30629 110472165
Asthma 14.73 11.80 125 86380 250166 110252628
Glomerular filtration rate decreased 14.71 11.80 53 86452 28903 110473891
Haemoglobin increased 14.71 11.80 26 86479 9121 110493673
Renal tubular atrophy 14.63 11.80 13 86492 2263 110500531
Mycetoma mycotic 14.62 11.80 7 86498 421 110502373
Sopor 14.59 11.80 62 86443 36484 110466310
Toxic epidermal necrolysis 14.23 11.80 14 86491 56713 110446081
Forced vital capacity decreased 14.17 11.80 12 86493 1958 110500836
Thrombocytopenia 14.15 11.80 190 86315 348695 110154099
Disease recurrence 14.13 11.80 16 86489 60768 110442026
Vitamin D deficiency 14.07 11.80 39 86466 18513 110484281
Blood pressure abnormal 14.01 11.80 44 86461 22380 110480414
Glycosylated haemoglobin abnormal 13.80 11.80 7 86498 477 110502317
Musculoskeletal stiffness 13.79 11.80 146 86359 279676 110223118
Stenosis 13.79 11.80 15 86490 3336 110499458
Anion gap increased 13.77 11.80 17 86488 4327 110498467
Hypomenorrhoea 13.76 11.80 7 86498 480 110502314
Muscle neoplasm 13.70 11.80 4 86501 58 110502736
Confusional state 13.69 11.80 471 86034 468209 110034585
Epilepsy 13.62 11.80 37 86468 100172 110402622
Staphylococcal infection 13.61 11.80 21 86484 69923 110432871
Device issue 13.58 11.80 5 86500 34530 110468264
Nephrotic syndrome 13.52 11.80 32 86473 13799 110488995
Device dislocation 13.50 11.80 4 86501 31700 110471094
Abortion spontaneous 13.42 11.80 5 86500 34277 110468517
Sciatica 13.41 11.80 33 86472 92366 110410428
Hyperchylomicronaemia 13.39 11.80 4 86501 63 110502731
Deep vein thrombosis 13.38 11.80 60 86445 139827 110362967
Irregular sleep phase 13.38 11.80 5 86500 161 110502633
Oral mucosal blistering 13.34 11.80 23 86482 7911 110494883
Atrial fibrillation 13.31 11.80 253 86252 229389 110273405
Ketosis 13.27 11.80 11 86494 1743 110501051
Flushing 13.26 11.80 40 86465 104696 110398098
Ocular myasthenia 13.22 11.80 8 86497 770 110502024
Atrophic vulvovaginitis 13.21 11.80 10 86495 1390 110501404
Hypocalcaemia 13.18 11.80 92 86413 65274 110437520
Ventricular fibrillation 13.15 11.80 8 86497 41305 110461489
Gastrointestinal bacterial infection 13.10 11.80 10 86495 1408 110501386
Haematoma muscle 12.96 11.80 16 86489 4074 110498720
Breast cancer 12.93 11.80 7 86498 38535 110464259
Labelled drug-drug interaction issue 12.92 11.80 16 86489 4085 110498709
Blood pressure diastolic decreased 12.90 11.80 59 86446 35826 110466968
Carcinoid crisis 12.90 11.80 7 86498 548 110502246
Latent autoimmune diabetes in adults 12.86 11.80 5 86500 180 110502614
Heart rate irregular 12.81 11.80 57 86448 34217 110468577
Eyelid injury 12.78 11.80 5 86500 183 110502611
Bursitis infective 12.74 11.80 10 86495 1466 110501328
Lymphatic system neoplasm 12.74 11.80 4 86501 75 110502719
Antipsychotic drug level increased 12.67 11.80 21 86484 6994 110495800
Immunisation 12.67 11.80 14 86491 3169 110499625
Productive cough 12.65 11.80 141 86364 114164 110388630
Traumatic shock 12.64 11.80 3 86502 18 110502776
Bone marrow failure 12.62 11.80 16 86489 57832 110444962
Torticollis 12.53 11.80 14 86491 3207 110499587
Blindness 12.50 11.80 59 86446 36300 110466494
Skin ulcer 12.50 11.80 89 86416 63556 110439238
Lymphopenia 12.48 11.80 8 86497 40162 110462632
Thirst decreased 12.46 11.80 6 86499 365 110502429
Hyperintensity in brain deep nuclei 12.46 11.80 5 86500 196 110502598
Hypovolaemic shock 12.42 11.80 32 86473 14551 110488243
Cardiorenal syndrome 12.42 11.80 11 86494 1907 110500887
Anosmia 12.35 11.80 29 86476 12443 110490351
Insomnia 12.33 11.80 203 86302 360387 110142407
Gastric varices 12.32 11.80 8 86497 871 110501923
Gallbladder neoplasm 12.27 11.80 4 86501 85 110502709
Gingival hypertrophy 12.23 11.80 16 86489 4315 110498479
Type 2 diabetes mellitus 12.07 11.80 85 86420 177147 110325647
Ear infection 12.05 11.80 19 86486 62713 110440081
Catheter site thrombosis 12.03 11.80 7 86498 627 110502167
Diabetes mellitus management 12.00 11.80 3 86502 23 110502771
Base excess decreased 11.98 11.80 6 86499 398 110502396
Hospitalisation 11.97 11.80 64 86441 142429 110360365
Muscle strength abnormal 11.96 11.80 6 86499 399 110502395
Polyp 11.91 11.80 25 86480 9955 110492839
Hepatocellular injury 11.86 11.80 74 86431 50568 110452226
Oedema 11.85 11.80 106 86399 209870 110292924
Blood pressure diastolic increased 11.84 11.80 37 86468 18770 110484024
Lipid metabolism disorder 11.83 11.80 7 86498 647 110502147

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB09 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:48578 radical scavenger
CHEBI has role CHEBI:90415 insulin secretagogue

Related Drugs by ATC class:

A10BB Sulfonylureas 12 drugs
acetohexamidecarbutamidechlorpropamideglibenclamideglibornurideglimepirideglipizidegliquidoneglisoxepidemetahexamidetolazamidetolbutamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.97 acidic
pKa2 3.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 6.22 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.71 CHEMBL
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 5.13 WOMBAT-PK

External reference:

IDSource
N0000166470 NUI
D01599 KEGG_DRUG
C0017631 UMLSCUI
CHEBI:31654 CHEBI
GCZ PDB_CHEM_ID
CHEMBL427216 ChEMBL_ID
DB01120 DRUGBANK_ID
D005907 MESH_DESCRIPTOR_UI
3475 PUBCHEM_CID
3056 INN_ID
G4PX8C4HKV UNII
4816 RXNORM
003858 NDDF
325238000 SNOMEDCT_US
395731001 SNOMEDCT_US

Pharmaceutical products:

None