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| Stem definition | Drug id | CAS RN |
|---|---|---|
| humanized origin | 4971 | 347396-82-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION.
|
None
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 21, 2009 | PMDA | Novartis Pharma | |
| June 30, 2006 | FDA | GENENTECH | |
| Jan. 22, 2007 | EMA | Novartis Europharm Limited |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 3082.95 | 26.08 | 745 | 16652 | 22665 | 90588385 |
| Endophthalmitis | 1347.89 | 26.08 | 283 | 17114 | 4402 | 90606648 |
| Death | 1289.01 | 26.08 | 894 | 16503 | 455657 | 90155393 |
| Retinal haemorrhage | 989.42 | 26.08 | 228 | 17169 | 5536 | 90605514 |
| Cerebrovascular accident | 835.78 | 26.08 | 427 | 16970 | 123106 | 90487944 |
| Blindness | 820.78 | 26.08 | 273 | 17124 | 26295 | 90584755 |
| Retinal pigment epithelial tear | 747.97 | 26.08 | 112 | 17285 | 159 | 90610891 |
| Detachment of retinal pigment epithelium | 735.05 | 26.08 | 120 | 17277 | 385 | 90610665 |
| Eye haemorrhage | 673.45 | 26.08 | 188 | 17209 | 9992 | 90601058 |
| No adverse event | 665.40 | 26.08 | 303 | 17094 | 67679 | 90543371 |
| Retinal oedema | 631.66 | 26.08 | 118 | 17279 | 958 | 90610092 |
| Vitreous floaters | 623.24 | 26.08 | 166 | 17231 | 7383 | 90603667 |
| Visual impairment | 588.54 | 26.08 | 347 | 17050 | 132018 | 90479032 |
| Macular oedema | 581.74 | 26.08 | 144 | 17253 | 4765 | 90606285 |
| Vitreous haemorrhage | 543.10 | 26.08 | 121 | 17276 | 2505 | 90608545 |
| Subretinal fluid | 528.15 | 26.08 | 95 | 17302 | 609 | 90610441 |
| Eye pain | 515.94 | 26.08 | 223 | 17174 | 43945 | 90567105 |
| Age-related macular degeneration | 447.33 | 26.08 | 83 | 17314 | 646 | 90610404 |
| Photopsia | 374.70 | 26.08 | 102 | 17295 | 4922 | 90606128 |
| Metamorphopsia | 356.03 | 26.08 | 77 | 17320 | 1380 | 90609670 |
| Eye discharge | 349.83 | 26.08 | 108 | 17289 | 8150 | 90602900 |
| Vision blurred | 341.08 | 26.08 | 230 | 17167 | 110063 | 90500987 |
| Intraocular pressure increased | 327.00 | 26.08 | 99 | 17298 | 6994 | 90604056 |
| Eye pruritus | 288.65 | 26.08 | 131 | 17266 | 28896 | 90582154 |
| Choroidal neovascularisation | 286.19 | 26.08 | 52 | 17345 | 355 | 90610695 |
| Eye inflammation | 267.57 | 26.08 | 87 | 17310 | 7764 | 90603286 |
| Retinal exudates | 264.32 | 26.08 | 53 | 17344 | 643 | 90610407 |
| Myocardial infarction | 251.22 | 26.08 | 188 | 17209 | 105784 | 90505266 |
| Retinal detachment | 250.48 | 26.08 | 80 | 17317 | 6742 | 90604308 |
| Transient ischaemic attack | 247.67 | 26.08 | 134 | 17263 | 43042 | 90568008 |
| Polypoidal choroidal vasculopathy | 245.73 | 26.08 | 36 | 17361 | 39 | 90611011 |
| Vitritis | 235.44 | 26.08 | 56 | 17341 | 1558 | 90609492 |
| Macular hole | 229.14 | 26.08 | 50 | 17347 | 935 | 90610115 |
| Retinal thickening | 224.46 | 26.08 | 43 | 17354 | 404 | 90610646 |
| Cystoid macular oedema | 220.79 | 26.08 | 56 | 17341 | 2044 | 90609006 |
| Eye irritation | 219.00 | 26.08 | 114 | 17283 | 33864 | 90577186 |
| Vitreous detachment | 199.53 | 26.08 | 53 | 17344 | 2325 | 90608725 |
| Dry throat | 191.75 | 26.08 | 68 | 17329 | 7892 | 90603158 |
| Retinal vein occlusion | 191.06 | 26.08 | 52 | 17345 | 2504 | 90608546 |
| Non-infectious endophthalmitis | 188.74 | 26.08 | 35 | 17362 | 271 | 90610779 |
| Macular fibrosis | 179.13 | 26.08 | 35 | 17362 | 368 | 90610682 |
| Iridocyclitis | 176.90 | 26.08 | 53 | 17344 | 3608 | 90607442 |
| Retinal disorder | 176.48 | 26.08 | 46 | 17351 | 1873 | 90609177 |
| Blindness unilateral | 167.23 | 26.08 | 61 | 17336 | 7675 | 90603375 |
| Subretinal fibrosis | 164.52 | 26.08 | 27 | 17370 | 90 | 90610960 |
| Retinal depigmentation | 163.11 | 26.08 | 31 | 17366 | 278 | 90610772 |
| Retinal scar | 162.71 | 26.08 | 28 | 17369 | 133 | 90610917 |
| Pharyngeal oedema | 162.12 | 26.08 | 70 | 17327 | 13701 | 90597349 |
| Uveitis | 161.93 | 26.08 | 73 | 17324 | 15830 | 90595220 |
| Ocular hyperaemia | 161.33 | 26.08 | 93 | 17304 | 33705 | 90577345 |
| Cataract nuclear | 159.78 | 26.08 | 38 | 17359 | 1056 | 90609994 |
| Vitreous opacities | 156.00 | 26.08 | 32 | 17365 | 438 | 90610612 |
| Off label use | 153.78 | 26.08 | 511 | 16886 | 1101741 | 89509309 |
| Cerebral infarction | 153.73 | 26.08 | 83 | 17314 | 26513 | 90584537 |
| Anterior chamber cell | 147.14 | 26.08 | 33 | 17364 | 703 | 90610347 |
| Retinal neovascularisation | 142.75 | 26.08 | 23 | 17374 | 66 | 90610984 |
| Cataract | 142.64 | 26.08 | 115 | 17282 | 71977 | 90539073 |
| Retinal cyst | 139.84 | 26.08 | 23 | 17374 | 78 | 90610972 |
| Macular degeneration | 133.72 | 26.08 | 86 | 17311 | 37884 | 90573166 |
| Retinal degeneration | 133.68 | 26.08 | 33 | 17364 | 1076 | 90609974 |
| Macular scar | 129.55 | 26.08 | 22 | 17375 | 95 | 90610955 |
| Ocular hypertension | 129.40 | 26.08 | 35 | 17362 | 1645 | 90609405 |
| Visual field defect | 116.88 | 26.08 | 46 | 17351 | 7120 | 90603930 |
| Retinal artery occlusion | 114.59 | 26.08 | 34 | 17363 | 2237 | 90608813 |
| Retinal ischaemia | 105.04 | 26.08 | 23 | 17374 | 437 | 90610613 |
| Retinal tear | 100.44 | 26.08 | 28 | 17369 | 1474 | 90609576 |
| Throat tightness | 94.57 | 26.08 | 63 | 17334 | 29421 | 90581629 |
| Retinal vascular disorder | 93.67 | 26.08 | 19 | 17378 | 245 | 90610805 |
| Vitreous disorder | 91.97 | 26.08 | 17 | 17380 | 129 | 90610921 |
| Disease progression | 89.23 | 26.08 | 129 | 17268 | 156486 | 90454564 |
| Hypopyon | 84.48 | 26.08 | 22 | 17375 | 892 | 90610158 |
| Retinal aneurysm | 84.11 | 26.08 | 17 | 17380 | 215 | 90610835 |
| Conjunctival erosion | 83.73 | 26.08 | 16 | 17381 | 148 | 90610902 |
| Glaucoma | 80.53 | 26.08 | 50 | 17347 | 20705 | 90590345 |
| Diarrhoea | 79.13 | 26.08 | 41 | 17356 | 939149 | 89671901 |
| Lacrimation increased | 77.70 | 26.08 | 54 | 17343 | 27008 | 90584042 |
| Dry age-related macular degeneration | 76.63 | 26.08 | 16 | 17381 | 240 | 90610810 |
| Rash | 76.07 | 26.08 | 29 | 17368 | 796071 | 89814979 |
| Alopecia | 75.54 | 26.08 | 5 | 17392 | 495066 | 90115984 |
| Macular pigmentation | 75.04 | 26.08 | 11 | 17386 | 12 | 90611038 |
| Retinal vasculitis | 73.11 | 26.08 | 22 | 17375 | 1519 | 90609531 |
| Eye oedema | 72.08 | 26.08 | 23 | 17374 | 1929 | 90609121 |
| Fatigue | 71.55 | 26.08 | 70 | 17327 | 1153953 | 89457097 |
| Foreign body sensation in eyes | 71.23 | 26.08 | 26 | 17371 | 3274 | 90607776 |
| Cutis laxa | 70.10 | 26.08 | 14 | 17383 | 166 | 90610884 |
| Conjunctival bleb | 69.55 | 26.08 | 12 | 17385 | 58 | 90610992 |
| Disease recurrence | 65.95 | 26.08 | 56 | 17341 | 37597 | 90573453 |
| Eye infection | 64.75 | 26.08 | 38 | 17359 | 14216 | 90596834 |
| Retinal drusen | 64.28 | 26.08 | 10 | 17387 | 21 | 90611029 |
| Joint swelling | 64.15 | 26.08 | 10 | 17387 | 503290 | 90107760 |
| Foreign body in eye | 63.30 | 26.08 | 13 | 17384 | 179 | 90610871 |
| Neovascular age-related macular degeneration | 63.02 | 26.08 | 15 | 17382 | 418 | 90610632 |
| Anterior chamber flare | 62.61 | 26.08 | 12 | 17385 | 113 | 90610937 |
| Maculopathy | 62.60 | 26.08 | 22 | 17375 | 2484 | 90608566 |
| Ophthalmological examination abnormal | 62.51 | 26.08 | 12 | 17385 | 114 | 90610936 |
| Eye disorder | 61.26 | 26.08 | 47 | 17350 | 27343 | 90583707 |
| Diabetic retinopathy | 60.98 | 26.08 | 22 | 17375 | 2680 | 90608370 |
| Ischaemic stroke | 60.76 | 26.08 | 43 | 17354 | 22123 | 90588927 |
| Drug intolerance | 59.10 | 26.08 | 8 | 17389 | 447583 | 90163467 |
| Suspected transmission of an infectious agent via product | 58.79 | 26.08 | 14 | 17383 | 391 | 90610659 |
| Ocular discomfort | 57.80 | 26.08 | 27 | 17370 | 6343 | 90604707 |
| Choroidal haemorrhage | 57.68 | 26.08 | 10 | 17387 | 50 | 90611000 |
| Posterior capsule opacification | 57.16 | 26.08 | 12 | 17385 | 185 | 90610865 |
| Retinoschisis | 53.14 | 26.08 | 8 | 17389 | 12 | 90611038 |
| Conjunctival haemorrhage | 52.68 | 26.08 | 22 | 17375 | 3962 | 90607088 |
| Pyrexia | 52.39 | 26.08 | 31 | 17366 | 660454 | 89950596 |
| Weight increased | 51.68 | 26.08 | 9 | 17388 | 417918 | 90193132 |
| Rheumatoid arthritis | 51.56 | 26.08 | 5 | 17392 | 362609 | 90248441 |
| Pain | 51.33 | 26.08 | 70 | 17327 | 996271 | 89614779 |
| Arthropathy | 49.66 | 26.08 | 6 | 17391 | 366236 | 90244814 |
| Blepharitis | 49.38 | 26.08 | 21 | 17376 | 3955 | 90607095 |
| Retinal fibrosis | 48.06 | 26.08 | 7 | 17390 | 7 | 90611043 |
| Abdominal discomfort | 47.87 | 26.08 | 16 | 17381 | 477312 | 90133738 |
| Peripheral swelling | 46.71 | 26.08 | 11 | 17386 | 413095 | 90197955 |
| Treatment failure | 46.53 | 26.08 | 3 | 17394 | 303925 | 90307125 |
| Atrial fibrillation | 46.25 | 26.08 | 88 | 17309 | 133523 | 90477527 |
| Tachyphylaxis | 45.06 | 26.08 | 11 | 17386 | 342 | 90610708 |
| Corneal oedema | 44.86 | 26.08 | 16 | 17381 | 1885 | 90609165 |
| Vomiting | 44.06 | 26.08 | 52 | 17345 | 788241 | 89822809 |
| Vitrectomy | 43.77 | 26.08 | 10 | 17387 | 232 | 90610818 |
| Retinopathy proliferative | 43.36 | 26.08 | 8 | 17389 | 60 | 90610990 |
| Anterior chamber inflammation | 43.16 | 26.08 | 11 | 17386 | 409 | 90610641 |
| Exudative retinopathy | 42.29 | 26.08 | 6 | 17391 | 4 | 90611046 |
| Photophobia | 42.17 | 26.08 | 34 | 17363 | 21235 | 90589815 |
| Swelling | 42.09 | 26.08 | 14 | 17383 | 419044 | 90192006 |
| Dysphonia | 41.92 | 26.08 | 56 | 17341 | 63028 | 90548022 |
| Visual acuity tests abnormal | 41.51 | 26.08 | 9 | 17388 | 163 | 90610887 |
| Stomatitis | 41.20 | 26.08 | 3 | 17394 | 274695 | 90336355 |
| Iritis | 40.97 | 26.08 | 18 | 17379 | 3668 | 90607382 |
| Pericarditis | 40.38 | 26.08 | 3 | 17394 | 270148 | 90340902 |
| Arthralgia | 39.73 | 26.08 | 55 | 17342 | 778467 | 89832583 |
| Dry eye | 39.38 | 26.08 | 52 | 17345 | 57879 | 90553171 |
| Sinusitis | 39.04 | 26.08 | 9 | 17388 | 343079 | 90267971 |
| Hypertensive crisis | 38.64 | 26.08 | 30 | 17367 | 17754 | 90593296 |
| Vitreal cells | 38.57 | 26.08 | 8 | 17389 | 116 | 90610934 |
| Myocardial ischaemia | 38.33 | 26.08 | 27 | 17370 | 13787 | 90597263 |
| Macular ischaemia | 38.24 | 26.08 | 7 | 17390 | 50 | 90611000 |
| Staphylococcus test positive | 38.14 | 26.08 | 18 | 17379 | 4327 | 90606723 |
| Device issue | 38.10 | 26.08 | 37 | 17360 | 29500 | 90581550 |
| Angina pectoris | 37.81 | 26.08 | 42 | 17355 | 39118 | 90571932 |
| Pruritus | 36.83 | 26.08 | 30 | 17367 | 541495 | 90069555 |
| Vitreous adhesions | 35.87 | 26.08 | 7 | 17390 | 73 | 90610977 |
| Vitreous degeneration | 35.50 | 26.08 | 6 | 17391 | 25 | 90611025 |
| Infection | 34.81 | 26.08 | 13 | 17384 | 362081 | 90248969 |
| Acute myocardial infarction | 34.69 | 26.08 | 38 | 17359 | 34852 | 90576198 |
| Intraocular lens implant | 34.16 | 26.08 | 9 | 17388 | 382 | 90610668 |
| Glare | 34.11 | 26.08 | 7 | 17390 | 96 | 90610954 |
| Haemorrhagic stroke | 34.01 | 26.08 | 19 | 17378 | 6477 | 90604573 |
| Decreased appetite | 33.79 | 26.08 | 15 | 17382 | 376525 | 90234525 |
| Macular detachment | 33.78 | 26.08 | 7 | 17390 | 101 | 90610949 |
| Hypotony of eye | 33.71 | 26.08 | 8 | 17389 | 220 | 90610830 |
| Conjunctival hyperaemia | 33.69 | 26.08 | 15 | 17382 | 3154 | 90607896 |
| Diabetic retinal oedema | 33.48 | 26.08 | 9 | 17388 | 413 | 90610637 |
| Cataract subcapsular | 32.81 | 26.08 | 10 | 17387 | 721 | 90610329 |
| Dyspnoea | 32.57 | 26.08 | 76 | 17321 | 880879 | 89730171 |
| Cataract cortical | 31.65 | 26.08 | 6 | 17391 | 53 | 90610997 |
| Conjunctival disorder | 31.22 | 26.08 | 8 | 17389 | 304 | 90610746 |
| Gastrointestinal disorder | 30.69 | 26.08 | 6 | 17391 | 256681 | 90354369 |
| Corneal opacity | 30.64 | 26.08 | 10 | 17387 | 901 | 90610149 |
| Psoriatic arthropathy | 30.30 | 26.08 | 4 | 17393 | 228331 | 90382719 |
| Abdominal pain upper | 30.24 | 26.08 | 13 | 17384 | 332661 | 90278389 |
| Pain in extremity | 29.34 | 26.08 | 26 | 17371 | 450503 | 90160547 |
| Conjunctival retraction | 29.18 | 26.08 | 5 | 17392 | 23 | 90611027 |
| Xerophthalmia | 29.18 | 26.08 | 9 | 17388 | 675 | 90610375 |
| Retinal vascular occlusion | 28.48 | 26.08 | 8 | 17389 | 433 | 90610617 |
| Weight decreased | 28.46 | 26.08 | 19 | 17378 | 379891 | 90231159 |
| Blister | 28.39 | 26.08 | 7 | 17390 | 254991 | 90356059 |
| Corneal striae | 28.36 | 26.08 | 5 | 17392 | 28 | 90611022 |
| Optical coherence tomography abnormal | 28.24 | 26.08 | 7 | 17390 | 232 | 90610818 |
| Macular cyst | 28.07 | 26.08 | 5 | 17392 | 30 | 90611020 |
| Posterior capsule rupture | 28.00 | 26.08 | 4 | 17393 | 3 | 90611047 |
| Choroidal effusion | 27.92 | 26.08 | 9 | 17388 | 780 | 90610270 |
| Musculoskeletal stiffness | 27.90 | 26.08 | 11 | 17386 | 296521 | 90314529 |
| Wheezing | 27.57 | 26.08 | 6 | 17391 | 238074 | 90372976 |
| Normal tension glaucoma | 27.04 | 26.08 | 5 | 17392 | 38 | 90611012 |
| Corneal abrasion | 27.04 | 26.08 | 10 | 17387 | 1306 | 90609744 |
| Choroidal detachment | 26.92 | 26.08 | 7 | 17390 | 282 | 90610768 |
| Abdominal pain | 26.78 | 26.08 | 22 | 17375 | 395699 | 90215351 |
| Abnormal sensation in eye | 26.45 | 26.08 | 11 | 17386 | 1960 | 90609090 |
| Open angle glaucoma | 26.43 | 26.08 | 7 | 17390 | 303 | 90610747 |
| Product use issue | 26.23 | 26.08 | 129 | 17268 | 329790 | 90281260 |
| Keratic precipitates | 26.15 | 26.08 | 7 | 17390 | 316 | 90610734 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 2988.39 | 30.78 | 769 | 13824 | 16781 | 42589961 |
| Retinal haemorrhage | 1247.31 | 30.78 | 307 | 14286 | 5463 | 42601279 |
| Macular oedema | 873.52 | 30.78 | 210 | 14383 | 3359 | 42603383 |
| Vitreous haemorrhage | 858.13 | 30.78 | 197 | 14396 | 2550 | 42604192 |
| Death | 845.40 | 30.78 | 910 | 13683 | 470275 | 42136467 |
| Subretinal fluid | 725.47 | 30.78 | 137 | 14456 | 606 | 42606136 |
| Endophthalmitis | 667.90 | 30.78 | 177 | 14416 | 4256 | 42602486 |
| Detachment of retinal pigment epithelium | 649.50 | 30.78 | 121 | 14472 | 489 | 42606253 |
| Retinal oedema | 611.51 | 30.78 | 124 | 14469 | 844 | 42605898 |
| Retinal pigment epithelial tear | 605.02 | 30.78 | 104 | 14489 | 230 | 42606512 |
| Vitreous floaters | 571.58 | 30.78 | 155 | 14438 | 4075 | 42602667 |
| No adverse event | 518.30 | 30.78 | 257 | 14336 | 38764 | 42567978 |
| Visual impairment | 476.88 | 30.78 | 251 | 14342 | 42862 | 42563880 |
| Cerebrovascular accident | 402.16 | 30.78 | 303 | 14290 | 96857 | 42509885 |
| Choroidal neovascularisation | 382.08 | 30.78 | 69 | 14524 | 224 | 42606518 |
| Eye haemorrhage | 345.39 | 30.78 | 108 | 14485 | 4722 | 42602020 |
| Polypoidal choroidal vasculopathy | 339.31 | 30.78 | 58 | 14535 | 122 | 42606620 |
| Intraocular pressure increased | 338.54 | 30.78 | 114 | 14479 | 6319 | 42600423 |
| Retinal detachment | 325.17 | 30.78 | 111 | 14482 | 6414 | 42600328 |
| Vision blurred | 284.94 | 30.78 | 195 | 14398 | 53504 | 42553238 |
| Blindness | 273.21 | 30.78 | 130 | 14463 | 17848 | 42588894 |
| Retinal exudates | 255.71 | 30.78 | 59 | 14534 | 778 | 42605964 |
| Eye pain | 252.24 | 30.78 | 121 | 14472 | 16909 | 42589833 |
| Myocardial infarction | 244.36 | 30.78 | 254 | 14339 | 123755 | 42482987 |
| Cerebral infarction | 234.20 | 30.78 | 141 | 14452 | 31028 | 42575714 |
| Cystoid macular oedema | 212.96 | 30.78 | 53 | 14540 | 980 | 42605762 |
| Cataract | 210.87 | 30.78 | 131 | 14462 | 30473 | 42576269 |
| Vitritis | 207.80 | 30.78 | 54 | 14539 | 1195 | 42605547 |
| Ocular hypertension | 197.94 | 30.78 | 51 | 14542 | 1090 | 42605652 |
| Metamorphopsia | 179.75 | 30.78 | 42 | 14551 | 587 | 42606155 |
| Macular hole | 169.96 | 30.78 | 36 | 14557 | 310 | 42606432 |
| Vitreous detachment | 169.38 | 30.78 | 44 | 14549 | 972 | 42605770 |
| Vitreous opacities | 169.38 | 30.78 | 38 | 14555 | 438 | 42606304 |
| Retinal disorder | 158.35 | 30.78 | 43 | 14550 | 1132 | 42605610 |
| Blindness transient | 156.91 | 30.78 | 52 | 14541 | 2737 | 42604005 |
| Retinal thickening | 153.00 | 30.78 | 34 | 14559 | 374 | 42606368 |
| Retinal vein occlusion | 152.96 | 30.78 | 47 | 14546 | 1934 | 42604808 |
| Diabetic retinopathy | 151.08 | 30.78 | 47 | 14546 | 2016 | 42604726 |
| Increased insulin requirement | 143.70 | 30.78 | 27 | 14566 | 115 | 42606627 |
| Ocular discomfort | 132.93 | 30.78 | 47 | 14546 | 3010 | 42603732 |
| Macular degeneration | 129.57 | 30.78 | 44 | 14549 | 2497 | 42604245 |
| Dry age-related macular degeneration | 129.55 | 30.78 | 24 | 14569 | 93 | 42606649 |
| Retinal tear | 125.84 | 30.78 | 35 | 14558 | 1009 | 42605733 |
| Cataract nuclear | 125.55 | 30.78 | 33 | 14560 | 764 | 42605978 |
| Eye inflammation | 123.11 | 30.78 | 45 | 14548 | 3173 | 42603569 |
| Disease recurrence | 118.88 | 30.78 | 91 | 14502 | 29587 | 42577155 |
| Subretinal fibrosis | 118.00 | 30.78 | 22 | 14571 | 89 | 42606653 |
| Eye disorder | 117.93 | 30.78 | 64 | 14529 | 11548 | 42595194 |
| Suture rupture | 116.17 | 30.78 | 28 | 14565 | 450 | 42606292 |
| Retinal ischaemia | 114.97 | 30.78 | 28 | 14565 | 471 | 42606271 |
| Retinal degeneration | 114.61 | 30.78 | 30 | 14563 | 683 | 42606059 |
| Vitreous disorder | 114.60 | 30.78 | 23 | 14570 | 147 | 42606595 |
| Macular fibrosis | 111.48 | 30.78 | 26 | 14567 | 360 | 42606382 |
| Glaucoma | 111.22 | 30.78 | 55 | 14538 | 8193 | 42598549 |
| Retinal cyst | 108.48 | 30.78 | 20 | 14573 | 75 | 42606667 |
| Anterior chamber inflammation | 105.09 | 30.78 | 25 | 14568 | 379 | 42606363 |
| Macular scar | 103.71 | 30.78 | 17 | 14576 | 24 | 42606718 |
| Disease progression | 102.00 | 30.78 | 179 | 14414 | 143477 | 42463265 |
| Blindness unilateral | 100.65 | 30.78 | 45 | 14548 | 5343 | 42601399 |
| Neovascular age-related macular degeneration | 100.45 | 30.78 | 22 | 14571 | 225 | 42606517 |
| Diarrhoea | 99.23 | 30.78 | 19 | 14574 | 460830 | 42145912 |
| Haemorrhage | 97.93 | 30.78 | 112 | 14481 | 60451 | 42546291 |
| Retinal scar | 96.11 | 30.78 | 23 | 14570 | 358 | 42606384 |
| Off label use | 95.42 | 30.78 | 450 | 14143 | 637885 | 41968857 |
| Ocular hyperaemia | 94.15 | 30.78 | 62 | 14531 | 15901 | 42590841 |
| Transient ischaemic attack | 92.40 | 30.78 | 83 | 14510 | 33656 | 42573086 |
| Retinal artery occlusion | 92.31 | 30.78 | 33 | 14560 | 2182 | 42604560 |
| Pyrexia | 89.70 | 30.78 | 14 | 14579 | 394028 | 42212714 |
| Hypopyon | 88.36 | 30.78 | 23 | 14570 | 512 | 42606230 |
| Retinal neovascularisation | 87.06 | 30.78 | 18 | 14575 | 136 | 42606606 |
| Retinal depigmentation | 86.57 | 30.78 | 16 | 14577 | 61 | 42606681 |
| Retinal vasculitis | 83.47 | 30.78 | 23 | 14570 | 640 | 42606102 |
| Age-related macular degeneration | 82.42 | 30.78 | 20 | 14573 | 331 | 42606411 |
| Uveitis | 80.28 | 30.78 | 46 | 14547 | 9212 | 42597530 |
| Serous retinal detachment | 79.72 | 30.78 | 24 | 14569 | 920 | 42605822 |
| Visual field defect | 78.91 | 30.78 | 37 | 14556 | 4901 | 42601841 |
| Retinal aneurysm | 77.14 | 30.78 | 16 | 14577 | 123 | 42606619 |
| Hyphaema | 77.07 | 30.78 | 22 | 14571 | 698 | 42606044 |
| Neovascularisation | 75.51 | 30.78 | 13 | 14580 | 29 | 42606713 |
| Diabetic retinal oedema | 74.31 | 30.78 | 17 | 14576 | 215 | 42606527 |
| Non-infectious endophthalmitis | 71.94 | 30.78 | 17 | 14576 | 250 | 42606492 |
| Diabetic foot | 71.59 | 30.78 | 30 | 14563 | 3043 | 42603699 |
| Posterior capsule opacification | 68.43 | 30.78 | 15 | 14578 | 154 | 42606588 |
| Corneal oedema | 68.06 | 30.78 | 24 | 14569 | 1524 | 42605218 |
| Anterior chamber cell | 67.16 | 30.78 | 18 | 14575 | 450 | 42606292 |
| Ocular vascular disorder | 66.92 | 30.78 | 15 | 14578 | 172 | 42606570 |
| Macular ischaemia | 66.68 | 30.78 | 15 | 14578 | 175 | 42606567 |
| Fatigue | 65.34 | 30.78 | 34 | 14559 | 435607 | 42171135 |
| Toxicity to various agents | 62.74 | 30.78 | 4 | 14589 | 229132 | 42377610 |
| Macular cyst | 59.51 | 30.78 | 9 | 14584 | 4 | 42606738 |
| Retinal vascular disorder | 59.36 | 30.78 | 14 | 14579 | 204 | 42606538 |
| Eye oedema | 58.88 | 30.78 | 19 | 14574 | 918 | 42605824 |
| Subretinal haematoma | 57.65 | 30.78 | 9 | 14584 | 7 | 42606735 |
| Acute kidney injury | 57.57 | 30.78 | 27 | 14566 | 367310 | 42239432 |
| Cutis laxa | 56.47 | 30.78 | 12 | 14581 | 105 | 42606637 |
| Nausea | 55.12 | 30.78 | 34 | 14559 | 396765 | 42209977 |
| Photopsia | 54.55 | 30.78 | 23 | 14570 | 2369 | 42604373 |
| Foreign body sensation in eyes | 54.49 | 30.78 | 18 | 14575 | 937 | 42605805 |
| Aphonia | 53.71 | 30.78 | 27 | 14566 | 4162 | 42602580 |
| Retinopathy proliferative | 53.10 | 30.78 | 11 | 14582 | 84 | 42606658 |
| Xerophthalmia | 51.73 | 30.78 | 12 | 14581 | 162 | 42606580 |
| Drug interaction | 51.35 | 30.78 | 14 | 14579 | 266985 | 42339757 |
| Hypotension | 50.51 | 30.78 | 13 | 14580 | 257618 | 42349124 |
| Neutropenia | 50.35 | 30.78 | 5 | 14588 | 199426 | 42407316 |
| Cataract traumatic | 48.86 | 30.78 | 7 | 14586 | 0 | 42606742 |
| Device issue | 48.82 | 30.78 | 39 | 14554 | 13470 | 42593272 |
| Keratic precipitates | 47.89 | 30.78 | 12 | 14581 | 228 | 42606514 |
| Iridocyclitis | 46.25 | 30.78 | 20 | 14573 | 2191 | 42604551 |
| Conjunctival haemorrhage | 45.97 | 30.78 | 23 | 14570 | 3510 | 42603232 |
| Vitreous haze | 45.33 | 30.78 | 9 | 14584 | 54 | 42606688 |
| Maculopathy | 44.73 | 30.78 | 16 | 14577 | 1059 | 42605683 |
| Poor peripheral circulation | 44.66 | 30.78 | 18 | 14575 | 1653 | 42605089 |
| Corneal erosion | 44.43 | 30.78 | 10 | 14583 | 117 | 42606625 |
| Vitrectomy | 42.84 | 30.78 | 10 | 14583 | 139 | 42606603 |
| Thrombocytopenia | 42.65 | 30.78 | 7 | 14586 | 190272 | 42416470 |
| Inappropriate schedule of product administration | 42.14 | 30.78 | 98 | 14495 | 95804 | 42510938 |
| Hypotony of eye | 42.12 | 30.78 | 11 | 14582 | 248 | 42606494 |
| Anaemia | 41.75 | 30.78 | 22 | 14571 | 280256 | 42326486 |
| Cataract subcapsular | 41.72 | 30.78 | 13 | 14580 | 560 | 42606182 |
| Myocardial ischaemia | 41.47 | 30.78 | 40 | 14553 | 17722 | 42589020 |
| Decreased appetite | 41.35 | 30.78 | 8 | 14585 | 193129 | 42413613 |
| Visual acuity reduced transiently | 38.69 | 30.78 | 9 | 14584 | 123 | 42606619 |
| Lacrimation increased | 38.39 | 30.78 | 32 | 14561 | 11726 | 42595016 |
| Conjunctival bleb | 37.61 | 30.78 | 7 | 14586 | 28 | 42606714 |
| Conjunctival hyperaemia | 36.45 | 30.78 | 19 | 14574 | 3157 | 42603585 |
| Pseudoendophthalmitis | 36.42 | 30.78 | 8 | 14585 | 83 | 42606659 |
| Intraocular lens implant | 36.40 | 30.78 | 10 | 14583 | 275 | 42606467 |
| Ophthalmological examination abnormal | 36.01 | 30.78 | 7 | 14586 | 37 | 42606705 |
| Vomiting | 35.96 | 30.78 | 28 | 14565 | 289695 | 42317047 |
| Visual acuity tests abnormal | 35.91 | 30.78 | 8 | 14585 | 89 | 42606653 |
| Ischaemic stroke | 35.69 | 30.78 | 41 | 14552 | 22192 | 42584550 |
| Choroidal haemorrhage | 34.84 | 30.78 | 8 | 14585 | 103 | 42606639 |
| Retinoschisis | 34.09 | 30.78 | 6 | 14587 | 16 | 42606726 |
| Rash | 34.07 | 30.78 | 27 | 14566 | 276927 | 42329815 |
| Corneal disorder | 33.90 | 30.78 | 13 | 14580 | 1046 | 42605696 |
| Vitreous adhesions | 33.82 | 30.78 | 6 | 14587 | 17 | 42606725 |
| Iritis | 33.65 | 30.78 | 15 | 14578 | 1767 | 42604975 |
| Eye irritation | 33.27 | 30.78 | 29 | 14564 | 11289 | 42595453 |
| Conjunctival erosion | 32.44 | 30.78 | 6 | 14587 | 23 | 42606719 |
| Constipation | 32.14 | 30.78 | 8 | 14585 | 162283 | 42444459 |
| Somnolence | 32.04 | 30.78 | 5 | 14588 | 141100 | 42465642 |
| Tachyphylaxis | 31.98 | 30.78 | 8 | 14585 | 151 | 42606591 |
| Abdominal pain | 31.34 | 30.78 | 13 | 14580 | 190458 | 42416284 |
| Corneal abrasion | 31.16 | 30.78 | 9 | 14584 | 298 | 42606444 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Visual acuity reduced | 4590.01 | 24.57 | 1102 | 21210 | 31071 | 110535916 |
| Retinal haemorrhage | 1519.06 | 24.57 | 358 | 21954 | 9143 | 110557844 |
| Endophthalmitis | 1518.28 | 24.57 | 348 | 21964 | 7839 | 110559148 |
| No adverse event | 1308.82 | 24.57 | 509 | 21803 | 73330 | 110493657 |
| Macular oedema | 1168.54 | 24.57 | 273 | 22039 | 6693 | 110560294 |
| Subretinal fluid | 1108.63 | 24.57 | 198 | 22114 | 1146 | 110565841 |
| Detachment of retinal pigment epithelium | 1036.10 | 24.57 | 179 | 22133 | 826 | 110566161 |
| Vitreous haemorrhage | 995.03 | 24.57 | 222 | 22090 | 4398 | 110562589 |
| Retinal pigment epithelial tear | 917.09 | 24.57 | 146 | 22166 | 354 | 110566633 |
| Death | 905.46 | 24.57 | 891 | 21421 | 697978 | 109869009 |
| Retinal oedema | 887.18 | 24.57 | 169 | 22143 | 1458 | 110565529 |
| Choroidal neovascularisation | 723.79 | 24.57 | 121 | 22191 | 438 | 110566549 |
| Vitreous floaters | 721.39 | 24.57 | 196 | 22116 | 8938 | 110558049 |
| Eye haemorrhage | 615.11 | 24.57 | 183 | 22129 | 11591 | 110555396 |
| Cerebrovascular accident | 589.18 | 24.57 | 397 | 21915 | 180887 | 110386100 |
| Visual impairment | 572.06 | 24.57 | 349 | 21963 | 134079 | 110432908 |
| Polypoidal choroidal vasculopathy | 555.21 | 24.57 | 86 | 22226 | 161 | 110566826 |
| Eye pain | 531.46 | 24.57 | 240 | 22072 | 49859 | 110517128 |
| Age-related macular degeneration | 480.33 | 24.57 | 93 | 22219 | 880 | 110566107 |
| Intraocular pressure increased | 477.95 | 24.57 | 148 | 22164 | 10728 | 110556259 |
| Retinal detachment | 449.92 | 24.57 | 142 | 22170 | 10958 | 110556029 |
| Blindness | 394.45 | 24.57 | 177 | 22135 | 36182 | 110530805 |
| Macular hole | 390.58 | 24.57 | 79 | 22233 | 952 | 110566035 |
| Retinal exudates | 384.76 | 24.57 | 81 | 22231 | 1203 | 110565784 |
| Vision blurred | 377.24 | 24.57 | 265 | 22047 | 128757 | 110438230 |
| Retinal thickening | 372.80 | 24.57 | 63 | 22249 | 247 | 110566740 |
| Cerebral infarction | 366.30 | 24.57 | 188 | 22124 | 51650 | 110515337 |
| Vitritis | 331.29 | 24.57 | 82 | 22230 | 2571 | 110564416 |
| Photopsia | 321.93 | 24.57 | 96 | 22216 | 6118 | 110560869 |
| Eye inflammation | 309.06 | 24.57 | 102 | 22210 | 9069 | 110557918 |
| Myocardial infarction | 286.30 | 24.57 | 266 | 22046 | 191817 | 110375170 |
| Off label use | 265.30 | 24.57 | 779 | 21533 | 1499406 | 109067581 |
| Metamorphopsia | 257.90 | 24.57 | 61 | 22251 | 1572 | 110565415 |
| Cataract | 257.45 | 24.57 | 174 | 22138 | 79311 | 110487676 |
| Retinal vein occlusion | 252.15 | 24.57 | 72 | 22240 | 3935 | 110563052 |
| Macular fibrosis | 241.99 | 24.57 | 50 | 22262 | 674 | 110566313 |
| Transient ischaemic attack | 241.13 | 24.57 | 154 | 22158 | 63828 | 110503159 |
| Cystoid macular oedema | 234.65 | 24.57 | 63 | 22249 | 2737 | 110564250 |
| Vitreous opacities | 231.75 | 24.57 | 50 | 22262 | 839 | 110566148 |
| Retinal disorder | 230.49 | 24.57 | 60 | 22252 | 2310 | 110564677 |
| Ocular hypertension | 229.54 | 24.57 | 60 | 22252 | 2348 | 110564639 |
| Vitreous detachment | 223.51 | 24.57 | 60 | 22252 | 2605 | 110564382 |
| Disease progression | 211.28 | 24.57 | 253 | 22059 | 243781 | 110323206 |
| Subretinal fibrosis | 207.58 | 24.57 | 36 | 22276 | 170 | 110566817 |
| Non-infectious endophthalmitis | 206.19 | 24.57 | 41 | 22271 | 450 | 110566537 |
| Retinal depigmentation | 205.61 | 24.57 | 39 | 22273 | 327 | 110566660 |
| Retinal ischaemia | 203.68 | 24.57 | 46 | 22266 | 961 | 110566026 |
| Macular degeneration | 202.07 | 24.57 | 95 | 22217 | 21564 | 110545423 |
| Retinal degeneration | 200.51 | 24.57 | 50 | 22262 | 1616 | 110565371 |
| Diabetic retinopathy | 197.43 | 24.57 | 58 | 22254 | 3506 | 110563481 |
| Retinal tear | 192.01 | 24.57 | 50 | 22262 | 1927 | 110565060 |
| Retinal cyst | 189.43 | 24.57 | 32 | 22280 | 125 | 110566862 |
| Retinal artery occlusion | 187.37 | 24.57 | 58 | 22254 | 4191 | 110562796 |
| Retinal neovascularisation | 186.86 | 24.57 | 34 | 22278 | 221 | 110566766 |
| Ocular hyperaemia | 184.86 | 24.57 | 109 | 22203 | 39177 | 110527810 |
| Dry age-related macular degeneration | 180.67 | 24.57 | 34 | 22278 | 272 | 110566715 |
| Uveitis | 180.56 | 24.57 | 88 | 22224 | 21622 | 110545365 |
| Dry throat | 178.55 | 24.57 | 68 | 22244 | 9170 | 110557817 |
| Vitreous disorder | 172.35 | 24.57 | 34 | 22278 | 357 | 110566630 |
| Iridocyclitis | 169.65 | 24.57 | 57 | 22255 | 5351 | 110561636 |
| Blindness unilateral | 167.69 | 24.57 | 66 | 22246 | 9720 | 110557267 |
| Anterior chamber cell | 163.88 | 24.57 | 40 | 22272 | 1181 | 110565806 |
| Ocular discomfort | 162.00 | 24.57 | 62 | 22250 | 8471 | 110558516 |
| Blindness transient | 160.40 | 24.57 | 56 | 22256 | 5900 | 110561087 |
| Retinal scar | 159.62 | 24.57 | 33 | 22279 | 446 | 110566541 |
| Cataract nuclear | 158.27 | 24.57 | 40 | 22272 | 1366 | 110565621 |
| Retinal vasculitis | 152.54 | 24.57 | 42 | 22270 | 2007 | 110564980 |
| Increased insulin requirement | 144.83 | 24.57 | 27 | 22285 | 204 | 110566783 |
| Visual field defect | 138.48 | 24.57 | 58 | 22254 | 10014 | 110556973 |
| Macular scar | 137.59 | 24.57 | 23 | 22289 | 83 | 110566904 |
| Neovascular age-related macular degeneration | 136.18 | 24.57 | 30 | 22282 | 557 | 110566430 |
| Pharyngeal oedema | 134.83 | 24.57 | 66 | 22246 | 16362 | 110550625 |
| Eye discharge | 132.52 | 24.57 | 54 | 22258 | 8700 | 110558287 |
| Retinal vascular disorder | 129.44 | 24.57 | 27 | 22285 | 382 | 110566605 |
| Hypopyon | 128.24 | 24.57 | 34 | 22278 | 1406 | 110565581 |
| Glaucoma | 126.08 | 24.57 | 70 | 22242 | 22447 | 110544540 |
| Eye disorder | 125.06 | 24.57 | 76 | 22236 | 28830 | 110538157 |
| Suture rupture | 119.75 | 24.57 | 28 | 22284 | 685 | 110566302 |
| Anterior chamber inflammation | 117.43 | 24.57 | 28 | 22284 | 747 | 110566240 |
| Diarrhoea | 113.93 | 24.57 | 44 | 22268 | 1139461 | 109427526 |
| Haemorrhage | 109.66 | 24.57 | 121 | 22191 | 106571 | 110460416 |
| Eye pruritus | 109.02 | 24.57 | 73 | 22239 | 32702 | 110534285 |
| Retinal aneurysm | 103.65 | 24.57 | 21 | 22291 | 255 | 110566732 |
| Disease recurrence | 101.79 | 24.57 | 90 | 22222 | 60694 | 110506293 |
| Eye oedema | 100.56 | 24.57 | 32 | 22280 | 2530 | 110564457 |
| Device issue | 98.56 | 24.57 | 70 | 22242 | 34465 | 110532522 |
| Choroidal haemorrhage | 98.08 | 24.57 | 19 | 22293 | 180 | 110566807 |
| Pyrexia | 96 | 24.57 | 31 | 22281 | 898234 | 109668753 |
| Corneal oedema | 93.84 | 24.57 | 32 | 22280 | 3141 | 110563846 |
| Serous retinal detachment | 91.68 | 24.57 | 27 | 22285 | 1645 | 110565342 |
| Conjunctival bleb | 90.33 | 24.57 | 17 | 22295 | 136 | 110566851 |
| Retinopathy proliferative | 89.68 | 24.57 | 17 | 22295 | 142 | 110566845 |
| Posterior capsule opacification | 86.74 | 24.57 | 18 | 22294 | 248 | 110566739 |
| Throat tightness | 86.73 | 24.57 | 64 | 22248 | 33425 | 110533562 |
| Diabetic foot | 85.86 | 24.57 | 32 | 22280 | 4063 | 110562924 |
| Hyphaema | 83.83 | 24.57 | 23 | 22289 | 1084 | 110565903 |
| Macular ischaemia | 82.62 | 24.57 | 17 | 22295 | 224 | 110566763 |
| Toxicity to various agents | 80.40 | 24.57 | 4 | 22308 | 480551 | 110086436 |
| Macular cyst | 78.64 | 24.57 | 13 | 22299 | 43 | 110566944 |
| Fatigue | 78.58 | 24.57 | 78 | 22234 | 1215880 | 109351107 |
| Xerophthalmia | 77.81 | 24.57 | 21 | 22291 | 930 | 110566057 |
| Retinoschisis | 77.74 | 24.57 | 13 | 22299 | 47 | 110566940 |
| Foreign body sensation in eyes | 77.09 | 24.57 | 28 | 22284 | 3306 | 110563681 |
| Ischaemic stroke | 76.98 | 24.57 | 65 | 22247 | 41198 | 110525789 |
| Rash | 76.61 | 24.57 | 35 | 22277 | 820929 | 109746058 |
| Visual acuity tests abnormal | 75.48 | 24.57 | 15 | 22297 | 164 | 110566823 |
| Lacrimation increased | 70.96 | 24.57 | 55 | 22257 | 30895 | 110536092 |
| Joint swelling | 70.09 | 24.57 | 5 | 22307 | 442840 | 110124147 |
| Keratic precipitates | 68.47 | 24.57 | 17 | 22295 | 539 | 110566448 |
| Conjunctival haemorrhage | 67.78 | 24.57 | 31 | 22281 | 6602 | 110560385 |
| Vomiting | 67.77 | 24.57 | 51 | 22261 | 910624 | 109656363 |
| Exudative retinopathy | 66.34 | 24.57 | 10 | 22302 | 14 | 110566973 |
| Cutis laxa | 65.43 | 24.57 | 13 | 22299 | 142 | 110566845 |
| Drug interaction | 63.54 | 24.57 | 12 | 22300 | 500171 | 110066816 |
| Nausea | 63.19 | 24.57 | 95 | 22217 | 1235595 | 109331392 |
| Weight increased | 62.92 | 24.57 | 6 | 22306 | 419638 | 110147349 |
| Ophthalmological examination abnormal | 62.73 | 24.57 | 11 | 22301 | 56 | 110566931 |
| Anterior chamber flare | 61.00 | 24.57 | 13 | 22299 | 205 | 110566782 |
| Eye irritation | 60.97 | 24.57 | 52 | 22260 | 33400 | 110533587 |
| Conjunctival erosion | 58.97 | 24.57 | 13 | 22299 | 242 | 110566745 |
| Optical coherence tomography abnormal | 58.91 | 24.57 | 12 | 22300 | 150 | 110566837 |
| Alopecia | 58.05 | 24.57 | 4 | 22308 | 364749 | 110202238 |
| Drug intolerance | 57.92 | 24.57 | 7 | 22305 | 406505 | 110160482 |
| Subretinal haematoma | 57.69 | 24.57 | 10 | 22302 | 47 | 110566940 |
| Maculopathy | 57.47 | 24.57 | 22 | 22290 | 3005 | 110563982 |
| Tachyphylaxis | 57.10 | 24.57 | 14 | 22298 | 421 | 110566566 |
| Vitreous haze | 55.97 | 24.57 | 11 | 22301 | 113 | 110566874 |
| Abdominal pain | 55.96 | 24.57 | 17 | 22295 | 512972 | 110054015 |
| Decreased appetite | 55.20 | 24.57 | 14 | 22298 | 475832 | 110091155 |
| Cataract subcapsular | 54.70 | 24.57 | 17 | 22295 | 1244 | 110565743 |
| Iritis | 51.52 | 24.57 | 23 | 22289 | 4629 | 110562358 |
| Hypotony of eye | 50.93 | 24.57 | 13 | 22299 | 462 | 110566525 |
| Staphylococcus test positive | 49.90 | 24.57 | 26 | 22286 | 7344 | 110559643 |
| Vitreous adhesions | 49.39 | 24.57 | 9 | 22303 | 59 | 110566928 |
| Suspected transmission of an infectious agent via product | 48.88 | 24.57 | 16 | 22296 | 1384 | 110565603 |
| Retinal drusen | 48.27 | 24.57 | 9 | 22303 | 68 | 110566919 |
| Retinal vascular occlusion | 47.33 | 24.57 | 13 | 22299 | 615 | 110566372 |
| Pain | 47.22 | 24.57 | 75 | 22237 | 954880 | 109612107 |
| Diabetic retinal oedema | 46.86 | 24.57 | 12 | 22300 | 432 | 110566555 |
| Abdominal discomfort | 46.82 | 24.57 | 11 | 22301 | 393847 | 110173140 |
| Hypotension | 46.26 | 24.57 | 24 | 22288 | 523825 | 110043162 |
| Rheumatoid arthritis | 45.66 | 24.57 | 4 | 22308 | 299609 | 110267378 |
| Visual acuity reduced transiently | 45.59 | 24.57 | 11 | 22301 | 309 | 110566678 |
| Detachment of macular retinal pigment epithelium | 45.57 | 24.57 | 7 | 22305 | 12 | 110566975 |
| Vitreous degeneration | 45.42 | 24.57 | 8 | 22304 | 42 | 110566945 |
| Pruritus | 45.24 | 24.57 | 31 | 22281 | 581529 | 109985458 |
| Retinal pallor | 45.05 | 24.57 | 6 | 22306 | 0 | 110566987 |
| Retinal pigment epitheliopathy | 44.76 | 24.57 | 12 | 22300 | 518 | 110566469 |
| Ocular vascular disorder | 44.51 | 24.57 | 13 | 22299 | 769 | 110566218 |
| Conjunctival retraction | 43.83 | 24.57 | 8 | 22304 | 53 | 110566934 |
| Aphonia | 43.61 | 24.57 | 29 | 22283 | 12831 | 110554156 |
| Stomatitis | 42.88 | 24.57 | 3 | 22309 | 270239 | 110296748 |
| Angina pectoris | 41.79 | 24.57 | 57 | 22255 | 62238 | 110504749 |
| Inappropriate schedule of product administration | 41.52 | 24.57 | 112 | 22200 | 203525 | 110363462 |
| Iris neovascularisation | 40.72 | 24.57 | 8 | 22304 | 82 | 110566905 |
| Pseudoendophthalmitis | 40.72 | 24.57 | 8 | 22304 | 82 | 110566905 |
| Eye infection | 40.43 | 24.57 | 29 | 22283 | 14489 | 110552498 |
| Pain in extremity | 39.18 | 24.57 | 25 | 22287 | 487093 | 110079894 |
| Macular pigmentation | 38.46 | 24.57 | 6 | 22306 | 12 | 110566975 |
| Macular detachment | 37.50 | 24.57 | 9 | 22303 | 247 | 110566740 |
| Retinal occlusive vasculitis | 37.46 | 24.57 | 9 | 22303 | 248 | 110566739 |
| Fundoscopy abnormal | 36.97 | 24.57 | 7 | 22305 | 58 | 110566929 |
| Vitrectomy | 36.83 | 24.57 | 9 | 22303 | 267 | 110566720 |
| Retinal fibrosis | 36.74 | 24.57 | 6 | 22306 | 18 | 110566969 |
| Retinal injury | 36.49 | 24.57 | 10 | 22302 | 469 | 110566518 |
| Peripheral swelling | 36.42 | 24.57 | 18 | 22294 | 404016 | 110162971 |
| Wound | 36.07 | 24.57 | 3 | 22309 | 234434 | 110332553 |
| Arthralgia | 35.94 | 24.57 | 64 | 22248 | 779568 | 109787419 |
| Acute myocardial infarction | 35.53 | 24.57 | 62 | 22250 | 83715 | 110483272 |
| Drug resistance | 35.44 | 24.57 | 50 | 22262 | 56324 | 110510663 |
| Posterior capsule rupture | 35.40 | 24.57 | 6 | 22306 | 24 | 110566963 |
| Conjunctival hyperaemia | 35.04 | 24.57 | 19 | 22293 | 5812 | 110561175 |
| Vitreal cells | 35.02 | 24.57 | 8 | 22304 | 176 | 110566811 |
| Haemorrhagic stroke | 34.90 | 24.57 | 26 | 22286 | 13763 | 110553224 |
| Dysphonia | 34.58 | 24.57 | 58 | 22254 | 75871 | 110491116 |
| Choroidal effusion | 34.45 | 24.57 | 11 | 22301 | 879 | 110566108 |
| Neovascularisation | 34.33 | 24.57 | 13 | 22299 | 1724 | 110565263 |
| Arthropathy | 34.22 | 24.57 | 8 | 22304 | 287514 | 110279473 |
| Thrombocytopenia | 33.85 | 24.57 | 14 | 22298 | 348871 | 110218116 |
| Foreign body in eye | 33.62 | 24.57 | 9 | 22303 | 386 | 110566601 |
| Chorioretinal scar | 33.56 | 24.57 | 7 | 22305 | 99 | 110566888 |
| Macular thickening | 33.24 | 24.57 | 6 | 22306 | 37 | 110566950 |
| Anaemia | 33.06 | 24.57 | 37 | 22275 | 547049 | 110019938 |
| Dyspnoea | 32.93 | 24.57 | 114 | 22198 | 1106758 | 109460229 |
| Conjunctival disorder | 32.82 | 24.57 | 9 | 22303 | 423 | 110566564 |
| Wheezing | 32.64 | 24.57 | 6 | 22306 | 255224 | 110311763 |
| Insomnia | 32.59 | 24.57 | 16 | 22296 | 360574 | 110206413 |
| Corneal disorder | 32.52 | 24.57 | 14 | 22298 | 2583 | 110564404 |
| Weight decreased | 32.49 | 24.57 | 28 | 22284 | 468029 | 110098958 |
| Myocardial ischaemia | 32.23 | 24.57 | 33 | 22279 | 26651 | 110540336 |
| Blister | 32.16 | 24.57 | 4 | 22308 | 227372 | 110339615 |
| Sinusitis | 32.02 | 24.57 | 10 | 22302 | 296678 | 110270309 |
| Dry eye | 31.46 | 24.57 | 47 | 22265 | 55746 | 110511241 |
| Swelling | 31.09 | 24.57 | 16 | 22296 | 351025 | 110215962 |
| Blepharitis | 30.65 | 24.57 | 16 | 22296 | 4536 | 110562451 |
| Pericarditis | 30.63 | 24.57 | 4 | 22308 | 219110 | 110347877 |
| Somnolence | 30.40 | 24.57 | 11 | 22301 | 297438 | 110269549 |
| Open angle glaucoma | 30.30 | 24.57 | 9 | 22303 | 565 | 110566422 |
| Anterior chamber disorder | 30.22 | 24.57 | 7 | 22305 | 164 | 110566823 |
| Sudden visual loss | 29.38 | 24.57 | 6 | 22306 | 76 | 110566911 |
| Nasopharyngitis | 29.36 | 24.57 | 22 | 22290 | 394339 | 110172648 |
| Drug hypersensitivity | 29.35 | 24.57 | 29 | 22283 | 454061 | 110112926 |
| Musculoskeletal stiffness | 29.20 | 24.57 | 10 | 22302 | 279812 | 110287175 |
| Concomitant disease aggravated | 28.92 | 24.57 | 25 | 22287 | 16339 | 110550648 |
| COVID-19 | 28.80 | 24.57 | 7 | 22305 | 245053 | 110321934 |
| Intra-ocular injection complication | 28.44 | 24.57 | 6 | 22306 | 90 | 110566897 |
| Aneurysm | 28.15 | 24.57 | 15 | 22297 | 4431 | 110562556 |
| IIIrd nerve paresis | 28.13 | 24.57 | 7 | 22305 | 224 | 110566763 |
| Abnormal sensation in eye | 28.09 | 24.57 | 12 | 22300 | 2174 | 110564813 |
| Constipation | 27.89 | 24.57 | 19 | 22293 | 357767 | 110209220 |
| Corneal lesion | 27.68 | 24.57 | 6 | 22306 | 103 | 110566884 |
| Choroidal detachment | 27.67 | 24.57 | 9 | 22303 | 763 | 110566224 |
| Oedema peripheral | 27.62 | 24.57 | 16 | 22296 | 328644 | 110238343 |
| Giant cell arteritis | 27.62 | 24.57 | 14 | 22298 | 3735 | 110563252 |
| Intraocular lens implant | 27.61 | 24.57 | 8 | 22304 | 460 | 110566527 |
| Retinal perivascular sheathing | 27.36 | 24.57 | 6 | 22306 | 109 | 110566878 |
| Muscle spasms | 27.24 | 24.57 | 11 | 22301 | 278146 | 110288841 |
| Dry mouth | 27.13 | 24.57 | 4 | 22308 | 199944 | 110367043 |
| Asthenia | 27.08 | 24.57 | 62 | 22250 | 688937 | 109878050 |
| Corneal opacity | 27.05 | 24.57 | 10 | 22302 | 1241 | 110565746 |
| Asthenopia | 26.82 | 24.57 | 13 | 22299 | 3151 | 110563836 |
| Acute kidney injury | 26.78 | 24.57 | 55 | 22257 | 635375 | 109931612 |
| Pancytopenia | 26.65 | 24.57 | 5 | 22307 | 209608 | 110357379 |
| Tractional retinal detachment | 26.58 | 24.57 | 6 | 22306 | 125 | 110566862 |
| Psoriatic arthropathy | 26.55 | 24.57 | 4 | 22308 | 196757 | 110370230 |
| Cerebral haemorrhage | 26.15 | 24.57 | 47 | 22265 | 64921 | 110502066 |
| White blood cell count decreased | 26.09 | 24.57 | 7 | 22305 | 229383 | 110337604 |
| Angle closure glaucoma | 25.58 | 24.57 | 13 | 22299 | 3486 | 110563501 |
| Bacterial endophthalmitis | 25.41 | 24.57 | 7 | 22305 | 335 | 110566652 |
| Cataract cortical | 25.35 | 24.57 | 6 | 22306 | 155 | 110566832 |
| Overdose | 25.01 | 24.57 | 8 | 22304 | 233786 | 110333201 |
| Normal tension glaucoma | 24.73 | 24.57 | 5 | 22307 | 60 | 110566927 |
| Charles Bonnet syndrome | 24.73 | 24.57 | 5 | 22307 | 60 | 110566927 |
None
| Source | Code | Description |
|---|---|---|
| ATC | S01LA04 | SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| FDA MoA | N0000193542 | Vascular Endothelial Growth Factor Inhibitors |
| FDA EPC | N0000193543 | Vascular Endothelial Growth Factor Inhibitor |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic retinopathy | indication | 4855003 | DOID:8947 |
| Choroidal retinal neovascularization | indication | 75971007 | |
| Central retinal vein occlusion with macular edema | indication | 232039004 | |
| Branch retinal vein occlusion with macular edema | indication | 232048009 | |
| Age related macular degeneration | indication | 267718000 | DOID:10871 |
| Macular edema due to diabetes mellitus | indication | 312912001 | DOID:9191 |
| Exudative age-related macular degeneration | indication | 414173003 | DOID:10873 |
| Retinopathy of prematurity | indication | 415297005 | DOID:13025 |
| Eye infection | contraindication | 128351009 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor A | Secreted | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| D05697 | KEGG_DRUG |
| 4025260 | VUID |
| N0000179788 | NUI |
| 4025260 | VANDF |
| 4041511 | VANDF |
| CHEBI:749601 | CHEBI |
| CHEMBL1201825 | ChEMBL_ID |
| C000719192 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6779 | IUPHAR_LIGAND_ID |
| DB01270 | DRUGBANK_ID |
| 2602351 | RXNORM |
| 21678 | MMSL |
| 350639 | MMSL |
| 39922 | MMSL |
| 83454 | MMSL |
| 011622 | NDDF |
| 018852 | NDDF |
| 422456007 | SNOMEDCT_US |
| 425256004 | SNOMEDCT_US |
| C1566537 | UMLSCUI |
| D000069579 | MESH_DESCRIPTOR_UI |
| 8313 | INN_ID |
| ZL1R02VT79 | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Susvimo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-078 | INJECTION, SOLUTION | 100 mg | INTRAVITREAL | BLA | 30 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-080 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 28 sections |
| LUCENTIS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-082 | INJECTION, SOLUTION | 6 mg | INTRAVITREAL | BLA | 28 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-624 | INJECTION, SOLUTION | 0.30 mg | INTRAVITREAL | BLA | 29 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-625 | INJECTION, SOLUTION | 0.50 mg | INTRAVITREAL | BLA | 29 sections |
| Byooviz | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64406-019 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 31 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-440 | INJECTION, SOLUTION | 0.30 mg | INTRAVITREAL | BLA | 31 sections |
| CIMERLI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70114-441 | INJECTION, SOLUTION | 0.50 mg | INTRAVITREAL | BLA | 31 sections |
| NUFYMCO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-2172 | INJECTION, SOLUTION | 0.30 mg | INTRAVITREAL | BLA | 24 sections |
| NUFYMCO | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-2173 | INJECTION, SOLUTION | 0.50 mg | INTRAVITREAL | BLA | 24 sections |
| Byooviz | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82667-018 | INJECTION, SOLUTION | 10 mg | INTRAVITREAL | BLA | 31 sections |