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anecortave 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 217 | 7753-60-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 19 | |||
| kinase-selectivity-class | GRK2,MAP2K6 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 2006 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01LA02 | SENSORY ORGANS OPHTHALMOLOGICALS OCULAR VASCULAR DISORDER AGENTS Antineovascularisation agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
Related Drugs by ATC class:
S01LA Antineovascularisation agents 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Exudative age-related macular degeneration | indication | 414173003 | DOID:10873 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.5 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Plasminogen activator inhibitor 1 | Secreted | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D01733 | KEGG_DRUG |
| 10184-70-0 | SECONDARY_CAS_RN |
| CHEBI:31215 | CHEBI |
| CHEMBL2106613 | ChEMBL_ID |
| C108424 | MESH_SUPPLEMENTAL_RECORD_UI |
| C418047 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB12081 | DRUGBANK_ID |
| R5Y8O51589 | UNII |
| DB05288 | DRUGBANK_ID |
| C1693912 | UMLSCUI |
| 7074810 | PUBCHEM_CID |
| 7747 | INN_ID |
| 011285 | NDDF |
| 011286 | NDDF |
| R5Y8O51589 | INXIGHT DRUGS |
Pharmaceutical products:
None