AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
potassium canrenoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 477 | 2181-04-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic pregnadiene derivative with anti-aldosterone activity.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.40 | g | P |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,PDK1,PDK2,PDK4,PRKDC | 11 | |||
| kinase-selectivity-class | EIF2AK3,GRK2,MAP2K6,MAP3K14,TGFBR1 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sopor | 153.56 | 27.85 | 50 | 3166 | 24594 | 90600637 |
| Hyperkalaemia | 144.96 | 27.85 | 62 | 3154 | 64902 | 90560329 |
| Drug interaction | 127.07 | 27.85 | 93 | 3123 | 276360 | 90348871 |
| Lactic acidosis | 102.17 | 27.85 | 45 | 3171 | 50418 | 90574813 |
| Acute kidney injury | 100.26 | 27.85 | 86 | 3130 | 320301 | 90304930 |
| Hyponatraemia | 94.99 | 27.85 | 59 | 3157 | 133479 | 90491752 |
| Melaena | 76.82 | 27.85 | 33 | 3183 | 34764 | 90590467 |
| Syncope | 73.17 | 27.85 | 50 | 3166 | 132613 | 90492618 |
| Toxic epidermal necrolysis | 72.30 | 27.85 | 31 | 3185 | 32497 | 90592734 |
| Bradycardia | 69.75 | 27.85 | 41 | 3175 | 83806 | 90541425 |
| International normalised ratio increased | 67.12 | 27.85 | 33 | 3183 | 47283 | 90577948 |
| Metabolic acidosis | 48.32 | 27.85 | 28 | 3188 | 55648 | 90569583 |
| Dehydration | 46.51 | 27.85 | 45 | 3171 | 194402 | 90430829 |
| Anaemia | 43.77 | 27.85 | 58 | 3158 | 352744 | 90272487 |
| Hyponatraemic syndrome | 39.82 | 27.85 | 8 | 3208 | 566 | 90624665 |
| Hyponatraemic encephalopathy | 38.30 | 27.85 | 7 | 3209 | 299 | 90624932 |
| Necrotising colitis | 38.26 | 27.85 | 9 | 3207 | 1329 | 90623902 |
| Oliguria | 37.01 | 27.85 | 14 | 3202 | 10610 | 90614621 |
| Polyglandular disorder | 33.51 | 27.85 | 6 | 3210 | 228 | 90625003 |
| Hypoglycaemia | 33.04 | 27.85 | 24 | 3192 | 69824 | 90555407 |
| Electrocardiogram QT prolonged | 32.25 | 27.85 | 24 | 3192 | 72432 | 90552799 |
| Drug ineffective | 30.80 | 27.85 | 6 | 3210 | 1384292 | 89240939 |
| Asthenia | 30.75 | 27.85 | 62 | 3154 | 533689 | 90091542 |
| Vascular parkinsonism | 30.07 | 27.85 | 5 | 3211 | 122 | 90625109 |
| Hypokalaemia | 28.81 | 27.85 | 29 | 3187 | 131087 | 90494144 |
| Anaemia folate deficiency | 28.44 | 27.85 | 6 | 3210 | 540 | 90624691 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyperkalaemia | 178.93 | 30.66 | 90 | 2486 | 80368 | 42538391 |
| Sopor | 94.59 | 30.66 | 34 | 2542 | 13168 | 42605591 |
| Hypotension | 86.35 | 30.66 | 91 | 2485 | 257540 | 42361219 |
| Melaena | 84.81 | 30.66 | 43 | 2533 | 38703 | 42580056 |
| Anaemia | 83.45 | 30.66 | 93 | 2483 | 280185 | 42338574 |
| Drug interaction | 80.15 | 30.66 | 89 | 2487 | 266910 | 42351849 |
| Metabolic acidosis | 65.26 | 30.66 | 40 | 2536 | 51818 | 42566941 |
| Toxic epidermal necrolysis | 62.35 | 30.66 | 31 | 2545 | 26719 | 42592040 |
| Asthenia | 57.13 | 30.66 | 77 | 2499 | 280716 | 42338043 |
| Presyncope | 52.32 | 30.66 | 26 | 2550 | 22361 | 42596398 |
| Renal ischaemia | 40.73 | 30.66 | 11 | 2565 | 1659 | 42617100 |
| Acute kidney injury | 39.05 | 30.66 | 75 | 2501 | 367262 | 42251497 |
| Hyponatraemia | 35.82 | 30.66 | 37 | 2539 | 101425 | 42517334 |
| Oliguria | 31.59 | 30.66 | 14 | 2562 | 9299 | 42609460 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyperkalaemia | 314.64 | 25.42 | 151 | 5829 | 135645 | 110447674 |
| Sopor | 226.01 | 25.42 | 82 | 5898 | 36464 | 110546855 |
| Drug interaction | 188.28 | 25.42 | 179 | 5801 | 500004 | 110083315 |
| Melaena | 157.49 | 25.42 | 76 | 5904 | 68681 | 110514638 |
| Toxic epidermal necrolysis | 127.75 | 25.42 | 62 | 5918 | 56665 | 110526654 |
| Acute kidney injury | 123.38 | 25.42 | 161 | 5819 | 635269 | 109948050 |
| Anaemia | 117.80 | 25.42 | 146 | 5834 | 546940 | 110036379 |
| Metabolic acidosis | 110.06 | 25.42 | 68 | 5912 | 99676 | 110483643 |
| Hyponatraemia | 107.43 | 25.42 | 91 | 5889 | 217562 | 110365757 |
| Lactic acidosis | 104.24 | 25.42 | 64 | 5916 | 92747 | 110490572 |
| Syncope | 88.44 | 25.42 | 79 | 5901 | 202457 | 110380862 |
| Hypotension | 80.82 | 25.42 | 119 | 5861 | 523730 | 110059589 |
| Asthenia | 80.82 | 25.42 | 138 | 5842 | 688861 | 109894458 |
| Bradycardia | 78.67 | 25.42 | 66 | 5914 | 155451 | 110427868 |
| International normalised ratio increased | 73.17 | 25.42 | 50 | 5930 | 86722 | 110496597 |
| Oliguria | 62.82 | 25.42 | 27 | 5953 | 18630 | 110564689 |
| Presyncope | 58.15 | 25.42 | 35 | 5945 | 48852 | 110534467 |
| Dehydration | 51.13 | 25.42 | 69 | 5911 | 279442 | 110303877 |
| Haematuria | 43.52 | 25.42 | 36 | 5944 | 82969 | 110500350 |
| Electrocardiogram QT prolonged | 40.69 | 25.42 | 39 | 5941 | 108921 | 110474398 |
| Renal ischaemia | 38.33 | 25.42 | 11 | 5969 | 2312 | 110581007 |
| Hypokalaemia | 36.35 | 25.42 | 47 | 5933 | 182401 | 110400918 |
| Hypoglycaemia | 34.99 | 25.42 | 37 | 5943 | 116067 | 110467252 |
| Hyponatraemic syndrome | 33.84 | 25.42 | 8 | 5972 | 789 | 110582530 |
| Hyponatraemic encephalopathy | 33.52 | 25.42 | 7 | 5973 | 391 | 110582928 |
| Necrotising colitis | 32.02 | 25.42 | 9 | 5971 | 1756 | 110581563 |
| Polyglandular disorder | 30.69 | 25.42 | 6 | 5974 | 240 | 110583079 |
| Ascites | 30.52 | 25.42 | 31 | 5949 | 92777 | 110490542 |
| Loss of consciousness | 29.27 | 25.42 | 44 | 5936 | 196262 | 110387057 |
| Vascular parkinsonism | 28.08 | 25.42 | 5 | 5975 | 119 | 110583200 |
| Renal failure | 27.20 | 25.42 | 46 | 5934 | 226528 | 110356791 |
| Shock haemorrhagic | 26.07 | 25.42 | 17 | 5963 | 27230 | 110556089 |
| Rectal haemorrhage | 25.64 | 25.42 | 32 | 5948 | 119801 | 110463518 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C03DA02 | CARDIOVASCULAR SYSTEM DIURETICS ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS Aldosterone antagonists |
| MeSH PA | D000451 | Mineralocorticoid Receptor Antagonists |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D045283 | Natriuretic Agents |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:50113 | androgen |
Related Drugs by ATC class:
C03DA Aldosterone antagonists 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.78 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01943 | KEGG_DRUG |
| 1981 | RXNORM |
| CHEBI:749783 | CHEBI |
| CHEMBL1371200 | ChEMBL_ID |
| CHEMBL1616951 | ChEMBL_ID |
| 4138-96-9 | SECONDARY_CAS_RN |
| DB09015 | DRUGBANK_ID |
| 318053000 | SNOMEDCT_US |
| 419615001 | SNOMEDCT_US |
| C0006881 | UMLSCUI |
| D002191 | MESH_DESCRIPTOR_UI |
| 23671691 | PUBCHEM_CID |
| 2448 | INN_ID |
| 2571 | INN_ID |
| M671F9NLEA | UNII |
| 003944 | NDDF |
| 003945 | NDDF |
| M671F9NLEA | INXIGHT DRUGS |
Pharmaceutical products:
None