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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists	2475	52-01-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: spironolactone abbolactone aldactone aldopur berlactone euteberol quimolactona spirolactone	A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827) Molecular weight: 416.58 Formula: C24H32O4S CLOGP: 2.84 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 60.44 ALOGS: -5.32 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

spironolactone
abbolactone
aldactone
aldopur
berlactone
euteberol
quimolactona
spirolactone

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Molecular weight: 416.58
Formula: C24H32O4S
CLOGP: 2.84
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 60.44
ALOGS: -5.32
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
37.50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.02 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	13.72 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	95.40 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	2.564		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.746		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	61.660	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	46.559	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	23.400	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	27.180	%	High	1
herg	hERG pIC50	4.485	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	8.511	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	27.164	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	22.830	%	High	1
kinase-safety-class	ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKDC,STK33,SYK,TEK,TTK,ZAP70	40
kinase-selectivity-class	EIF2AK3,GRK2	2
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	0.753		Moderate	0.78
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.448		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	252.348		High	1
mppb	Mouse plasma protein binding (% unbound)	22.460		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.959		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	26.550	%	High	1
rat-kpuu-brain	Rat brain Kpuu	0.338	%	Moderate	0.78
rh-clint	Rat hepatocyte intrinsic clearance	115.345	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	72.410	%	High	1
rppb	Rat plasma protein binding (% unbound)	16.630	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	129.122	uM	High	1

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 1960	FDA	GD SEARLE LLC
May 26, 2023	EMA	Nova Laboratories Ireland Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperkalaemia	3117.73	9.97	1905	204575	63059	90358908
Acute kidney injury	2035.66	9.97	3037	203443	317350	90104617
Cardiac failure	1456.73	9.97	1507	204973	107989	90313978
Hyponatraemia	1149.92	9.97	1468	205012	132070	90289897
Pemphigus	697.27	9.97	9	206471	326855	90095112
Pulmonary arterial hypertension	687.81	9.97	530	205950	25657	90396310
Synovitis	686.86	9.97	13	206467	329739	90092228
Hypotension	657.56	9.97	1926	204554	323471	90098496
Hand deformity	641.95	9.97	6	206474	296356	90125611
Glossodynia	598.98	9.97	33	206447	321746	90100221
Drug interaction	597.78	9.97	1677	204803	274776	90147191
Right ventricular failure	594.46	9.97	429	206051	18776	90403191
Systemic lupus erythematosus	588.22	9.97	68	206412	361828	90060139
Arthropathy	587.42	9.97	72	206408	366170	90055797
Renal impairment	538.10	9.97	906	205574	104515	90317452
Infusion related reaction	537.42	9.97	143	206337	416637	90005330
Cardiac failure congestive	515.47	9.97	857	205623	97837	90324130
Pulmonary hypertension	507.64	9.97	553	205927	41970	90379997
Joint swelling	488.07	9.97	270	206210	503030	89918937
Hepatic encephalopathy	485.17	9.97	333	206147	13439	90408528
Ascites	480.14	9.97	568	205912	47172	90374795
Dyspnoea	470.72	9.97	3521	202959	877434	89544533
Duodenal ulcer perforation	459.53	9.97	9	206471	221279	90200688
Helicobacter infection	456.58	9.97	13	206467	226837	90195130
Dehydration	456.29	9.97	1216	205264	193231	90228736
Wound	449.73	9.97	75	206405	302905	90119062
Renal failure	437.84	9.97	940	205540	130067	90291900
Bradycardia	432.35	9.97	724	205756	83123	90338844
Drug intolerance	419.73	9.97	250	206230	447341	89974626
Folliculitis	417.68	9.97	10	206470	204343	90217624
Maternal exposure during pregnancy	413.17	9.97	152	206328	359911	90062056
Drug ineffective	412.21	9.97	1694	204786	1382604	89039363
Therapeutic product effect decreased	404.71	9.97	72	206408	277499	90144468
Atrial fibrillation	403.96	9.97	921	205559	132690	90289277
Pericarditis	400.63	9.97	67	206413	270084	90151883
Hepatic enzyme increased	388.19	9.97	168	206312	360568	90061399
Muscle injury	385.16	9.97	3	206477	176651	90245316
Contraindicated product administered	369.20	9.97	134	206346	320005	90101962
Rheumatoid arthritis	352.03	9.97	194	206286	362420	90059547
Treatment failure	342.43	9.97	132	206348	303796	90118171
Hypersensitivity	342.42	9.97	319	206161	454358	89967609
Alopecia	335.86	9.97	380	206100	494691	89927276
Blood creatinine increased	333.55	9.97	723	205757	100663	90321304
Psoriatic arthropathy	324.73	9.97	63	206417	228272	90193695
Discomfort	324.56	9.97	110	206370	274225	90147742
Irritable bowel syndrome	319.91	9.97	46	206434	207402	90214565
Impaired healing	317.88	9.97	72	206408	234127	90187840
International normalised ratio increased	312.63	9.97	458	206022	46858	90375109
Oedema peripheral	302.98	9.97	1277	205203	256638	90165329
Hypervolaemia	300.40	9.97	372	206108	32385	90389582
Lower respiratory tract infection	283.74	9.97	108	206372	250551	90171416
Musculoskeletal stiffness	282.90	9.97	162	206318	296370	90125597
Blood potassium increased	279.84	9.97	288	206192	20461	90401506
Abdominal discomfort	275.75	9.97	413	206067	476915	89945052
Type 2 diabetes mellitus	263.07	9.97	69	206411	203175	90218792
Pain	261.95	9.97	1275	205205	995066	89426901
Ill-defined disorder	254.59	9.97	55	206425	184836	90237131
Cardiac failure chronic	253.72	9.97	159	206321	5487	90416480
Stomatitis	252.27	9.97	157	206323	274541	90147426
Anaemia	250.27	9.97	1515	204965	351287	90070680
Fluid retention	241.89	9.97	585	205895	87506	90334461
Blood cholesterol increased	241.51	9.97	86	206394	207926	90214041
Joint range of motion decreased	240.07	9.97	18	206462	135625	90286342
Blood urea increased	232.95	9.97	316	206164	30097	90391870
Swelling	227.32	9.97	378	206102	418680	90003287
Exposure during pregnancy	224.85	9.97	132	206348	238278	90183689
Liver injury	224.39	9.97	56	206424	170511	90251456
Bursitis	223.30	9.97	21	206459	131633	90290334
Dyspnoea exertional	215.79	9.97	496	205984	71792	90350175
Sensitisation	214.28	9.97	128	206352	4047	90417920
Syncope	212.88	9.97	726	205754	131937	90290030
Polycystic ovaries	206.94	9.97	140	206340	5514	90416453
Mobility decreased	206.77	9.97	161	206319	250573	90171394
Lip dry	202.25	9.97	6	206474	100949	90321018
Melaena	201.76	9.97	317	206163	34480	90387487
Gastrointestinal haemorrhage	198.04	9.97	551	205929	89697	90332270
Injury	195.13	9.97	103	206377	197246	90224721
Hypokalaemia	190.96	9.97	695	205785	130421	90291546
Renal disorder	188.54	9.97	322	206158	37537	90384430
Blister	186.95	9.97	183	206297	254815	90167152
Drug hypersensitivity	185.33	9.97	497	205983	463112	89958855
Sleep disorder due to general medical condition, insomnia type	181.86	9.97	36	206444	128658	90293309
Ejection fraction	177.51	9.97	101	206379	2910	90419057
Product use issue	174.77	9.97	302	206178	329617	90092350
Rash	172.04	9.97	1086	205394	795014	89626953
Grip strength decreased	170.53	9.97	10	206470	92566	90329401
Product prescribing error	169.77	9.97	271	206209	29874	90392093
Fall	167.28	9.97	1755	204725	480055	89941912
Blood pressure decreased	163.07	9.97	456	206024	74439	90347528
Cardiac disorder	162.91	9.97	384	206096	56488	90365479
Arthralgia	162.61	9.97	1073	205407	777449	89644518
Osteoarthritis	162.20	9.97	125	206355	195605	90226362
Urticaria	157.79	9.97	295	206185	312439	90109528
Hypercholesterolaemia	151.74	9.97	24	206456	100868	90321099
Nasopharyngitis	148.29	9.97	456	206024	406648	90015319
Sinusitis	146.90	9.97	355	206125	342733	90079234
Hepatic failure	146.52	9.97	297	206183	39431	90382536
Orthopnoea	142.69	9.97	121	206359	6714	90415253
Hypoaesthesia	142.67	9.97	315	206165	313895	90108072
N-terminal prohormone brain natriuretic peptide increased	142.19	9.97	87	206393	2875	90419092
Wound infection	141.74	9.97	34	206446	106368	90315599
Live birth	141.38	9.97	10	206470	79097	90342870
Sleep disorder	140.68	9.97	146	206334	197884	90224083
Chronic kidney disease	140.62	9.97	336	206144	49855	90372112
Gait inability	139.58	9.97	80	206400	146376	90275591
Cardiac failure acute	138.61	9.97	153	206327	11776	90410191
Night sweats	138.28	9.97	60	206420	128706	90293261
Glomerular filtration rate decreased	134.34	9.97	179	206301	16753	90405214
BRASH syndrome	132.70	9.97	71	206409	1808	90420159
Ventricular tachycardia	132.16	9.97	217	206263	24491	90397476
Gastrointestinal disorder	130.46	9.97	241	206239	256446	90165521
Pulmonary oedema	130.27	9.97	373	206107	61707	90360260
Pain in jaw	129.90	9.97	317	206163	47668	90374299
Brain natriuretic peptide increased	124.73	9.97	106	206374	5899	90416068
Ejection fraction abnormal	124.29	9.97	75	206405	2416	90419551
Off label use	124.16	9.97	1768	204712	1100484	89321483
Lactic acidosis	123.67	9.97	321	206159	50142	90371825
Infection	122.51	9.97	419	206061	361675	90060292
Cardioactive drug level increased	122.11	9.97	73	206407	2311	90419656
Fibromyalgia	119.34	9.97	178	206302	206091	90215876
Pleural effusion	117.95	9.97	537	205943	111454	90310513
Hip arthroplasty	114.89	9.97	18	206462	76190	90345777
Atrioventricular block	114.62	9.97	120	206360	8695	90413272
Sleep apnoea syndrome	111.96	9.97	233	206247	31514	90390453
Red blood cell sedimentation rate increased	110.78	9.97	26	206454	82569	90339398
Intentional product use issue	110.76	9.97	203	206277	216689	90205278
Atrial flutter	109.77	9.97	129	206351	10629	90411338
Sciatica	109.23	9.97	47	206433	101335	90320632
Congestive cardiomyopathy	104.48	9.97	105	206375	7249	90414718
Epistaxis	104.07	9.97	427	206053	84698	90337269
Labelled drug-drug interaction medication error	103.39	9.97	146	206334	14436	90407531
Respiratory failure	102.61	9.97	537	205943	117881	90304086
Haematoma	102.56	9.97	255	206225	38793	90383174
Blepharospasm	102.07	9.97	6	206474	55439	90366528
Blood bilirubin increased	101.91	9.97	272	206208	43198	90378769
Arrhythmia	101.39	9.97	267	206213	42065	90379902
Cardiogenic shock	101.24	9.97	192	206288	24276	90397691
Cardiomegaly	100.93	9.97	166	206314	18759	90403208
Transfusion	100.93	9.97	159	206321	17329	90404638
Pulmonary fibrosis	100.61	9.97	60	206420	107443	90314524
Product monitoring error	100.14	9.97	83	206397	4461	90417506
Bone erosion	99.91	9.97	5	206475	53016	90368951
Paraesthesia	97.89	9.97	271	206209	250055	90171912
Atrioventricular block complete	97.39	9.97	116	206364	9695	90412272
Palpitations	96.61	9.97	587	205893	136141	90285826
Hypothyroidism	96.16	9.97	303	206177	52824	90369143
Hepatocellular carcinoma	95.80	9.97	63	206417	2365	90419602
Haematemesis	95.79	9.97	227	206253	33499	90388468
Peripheral venous disease	95.14	9.97	36	206444	83885	90338082
Rhinitis allergic	94.65	9.97	151	206329	16634	90405333
Autoimmune disorder	93.80	9.97	29	206451	76715	90345252
Ischaemic stroke	93.03	9.97	175	206305	21991	90399976
Knee arthroplasty	92.13	9.97	37	206443	83145	90338822
Blood sodium decreased	91.97	9.97	198	206282	27415	90394552
Blood test abnormal	91.16	9.97	168	206312	20784	90401183
Prescribed overdose	90.64	9.97	55	206425	97570	90324397
X-ray abnormal	89.89	9.97	3	206477	45421	90376546
Arthritis	87.74	9.97	154	206326	167161	90254806
Lower limb fracture	87.54	9.97	42	206438	84971	90336996
Drug abuse	87.40	9.97	39	206441	82308	90339659
Inflammation	86.06	9.97	173	206307	178419	90243548
Hepatic function abnormal	85.62	9.97	266	206214	46022	90375945
Sputum culture positive	85.36	9.97	57	206423	2196	90419771
Oxygen saturation decreased	84.06	9.97	474	206006	107009	90314958
Vital capacity decreased	83.69	9.97	52	206428	1767	90420200
Pulmonary arterial pressure increased	83.13	9.97	70	206410	3846	90418121
Dry mouth	82.27	9.97	186	206294	183873	90238094
Sinus node dysfunction	81.94	9.97	80	206400	5332	90416635
Pericardial effusion	81.87	9.97	226	206254	36607	90385360
Hypovolaemia	81.61	9.97	120	206360	12311	90409656
Tricuspid valve incompetence	80.28	9.97	140	206340	16591	90405376
C-reactive protein increased	78.90	9.97	186	206294	181203	90240764
Atrial tachycardia	78.70	9.97	82	206398	5908	90416059
Left ventricular failure	77.95	9.97	86	206394	6614	90415353
Reversible airways obstruction	77.14	9.97	51	206429	1932	90420035
Nail disorder	76.48	9.97	20	206460	59047	90362920
Onychomadesis	76.24	9.97	8	206472	45990	90375977
Cardiomyopathy	75.62	9.97	152	206328	20054	90401913
Electrolyte imbalance	75.37	9.97	167	206313	23578	90398389
Varices oesophageal	75.01	9.97	65	206415	3714	90418253
Body tinea	73.44	9.97	51	206429	2097	90419870
Febrile neutropenia	73.25	9.97	157	206323	158192	90263775
Generalised oedema	72.11	9.97	144	206336	18909	90403058
Completed suicide	72.06	9.97	138	206342	144920	90277047
Obesity	71.33	9.97	81	206399	105426	90316541
Carpal tunnel syndrome	71.17	9.97	164	206316	23764	90398203
Concomitant disease aggravated	71.06	9.97	108	206372	11410	90410557
Prothrombin time prolonged	69.52	9.97	98	206382	9674	90412293
Device related infection	69.41	9.97	170	206310	25616	90396351
Road traffic accident	69.16	9.97	86	206394	107540	90314427
Acute respiratory failure	68.89	9.97	235	206245	42683	90379284
Injection site reaction	68.68	9.97	65	206415	92015	90329952
Catheter site infection	68.26	9.97	74	206406	5580	90416387
Catheter management	68.04	9.97	56	206424	2980	90418987
Upper gastrointestinal haemorrhage	67.82	9.97	157	206323	22819	90399148
Pulmonary congestion	67.79	9.97	142	206338	19291	90402676
Nephrectomy	67.64	9.97	47	206433	1934	90420033
Haemoglobin decreased	67.29	9.97	613	205867	161343	90260624
Orthostatic hypotension	67.11	9.97	229	206251	41598	90380369
Wheezing	66.68	9.97	297	206183	237783	90184184
Mitral valve incompetence	66.58	9.97	154	206326	22370	90399597
Pregnancy	66.46	9.97	29	206451	62018	90359949
Product use in unapproved indication	65.69	9.97	472	206008	335764	90086203
Hypoxia	65.25	9.97	332	206148	72067	90349900
Inappropriate antidiuretic hormone secretion	65.12	9.97	140	206340	19365	90402602
Adverse drug reaction	64.32	9.97	104	206376	116597	90305370
Congestive hepatopathy	63.94	9.97	54	206426	2979	90418988
Exostosis	63.29	9.97	21	206459	53113	90368854
Cellulitis	63.16	9.97	390	206090	90947	90331020
Joint stiffness	63.15	9.97	51	206429	77991	90343976
Paracentesis	63.06	9.97	35	206445	960	90421007
Epilepsy	62.52	9.97	57	206423	82149	90339818
Inhibitory drug interaction	61.97	9.97	54	206426	3109	90418858
Product quality issue	61.53	9.97	54	206426	79271	90342696
Haemoptysis	61.18	9.97	191	206289	33129	90388838
Metabolic acidosis	60.87	9.97	270	206210	55406	90366561
Shock haemorrhagic	60.76	9.97	104	206376	12141	90409826
Blood potassium decreased	60.38	9.97	242	206238	47485	90374482
Rhabdomyolysis	60.20	9.97	254	206226	51002	90370965
Multiple organ dysfunction syndrome	59.25	9.97	310	206170	68026	90353941
Ejection fraction decreased	58.26	9.97	161	206319	26092	90395875
Ammonia increased	58.01	9.97	64	206416	4922	90417045
Hidradenitis	58.00	9.97	60	206420	4287	90417680
Coeliac disease	57.95	9.97	15	206465	44595	90377372
Musculoskeletal pain	57.27	9.97	199	206281	171052	90250915
Oesophageal varices haemorrhage	57.14	9.97	38	206442	1454	90420513
Cor pulmonale	56.94	9.97	43	206437	2017	90419950
Foot deformity	56.22	9.97	33	206447	59618	90362349
Cough	56.06	9.97	1165	205315	367797	90054170
Onychomycosis	55.94	9.97	9	206471	37367	90384600
Colitis ulcerative	55.87	9.97	34	206446	60232	90361735
Dyspepsia	55.00	9.97	248	206232	197912	90224055
Prescribed underdose	54.73	9.97	54	206426	74965	90347002
Back injury	54.54	9.97	19	206461	46603	90375364
Portal hypertension	54.10	9.97	60	206420	4641	90417326
Abdominal distension	54.08	9.97	494	205986	130107	90291860
Taste disorder	53.95	9.97	37	206443	61509	90360458
Anuria	53.71	9.97	110	206370	14708	90407259
Cardiac arrest	53.58	9.97	416	206064	104519	90317448
Hypoglycaemia	53.26	9.97	306	206174	69542	90352425
Dizziness	53.10	9.97	1736	204744	587548	89834419
Shock	52.87	9.97	165	206315	28613	90393354
Polyuria	52.11	9.97	87	206393	9953	90412014
Sinoatrial block	52.06	9.97	31	206449	974	90420993
Bronchial secretion retention	52.06	9.97	52	206428	3563	90418404
Aspartate aminotransferase increased	51.96	9.97	407	206073	102530	90319437
Blood alkaline phosphatase increased	50.19	9.97	230	206250	47849	90374118
Gamma-glutamyltransferase increased	50.08	9.97	195	206285	37757	90384210
Oliguria	49.80	9.97	88	206392	10536	90411431
Pemphigoid	49.25	9.97	80	206400	8946	90413021
Myocardial infarction	49.15	9.97	411	206069	105561	90316406
Therapeutic drug monitoring analysis not performed	48.86	9.97	33	206447	1296	90420671
Hypovolaemic shock	48.78	9.97	70	206410	7024	90414943
Hepatorenal syndrome	48.48	9.97	39	206441	2009	90419958
Blood cholesterol decreased	48.33	9.97	38	206442	1893	90420074
Platelet count decreased	48.33	9.97	501	205979	136468	90285499
Subdural haematoma	48.31	9.97	113	206367	16532	90405435
Lupus-like syndrome	47.50	9.97	26	206454	48820	90373147
Death	47.22	9.97	1368	205112	455183	89966784
Migraine	47.20	9.97	248	206232	190144	90231823
Electrocardiogram QRS complex prolonged	46.89	9.97	70	206410	7278	90414689
Hepatic cirrhosis	46.86	9.97	275	206205	62978	90358989
Infection susceptibility increased	46.73	9.97	51	206429	3875	90418092
Poor quality sleep	46.68	9.97	143	206337	24550	90397417
Urinary retention	46.64	9.97	190	206290	37554	90384413
Lung disorder	46.28	9.97	180	206300	149703	90272264
Urine output decreased	46.20	9.97	94	206386	12509	90409458
Intentional overdose	45.96	9.97	90	206390	93744	90328223
Muscle spasticity	45.65	9.97	12	206468	35310	90386657
Drug tolerance decreased	45.35	9.97	9	206471	32121	90389846
Prerenal failure	45.30	9.97	38	206442	2077	90419890
Liver function test increased	44.56	9.97	78	206402	84777	90337190
Multiple allergies	44.16	9.97	103	206377	15043	90406924
Ventricular fibrillation	43.70	9.97	98	206382	13946	90408021
Jaundice	43.66	9.97	168	206312	32349	90389618
Concomitant disease progression	43.52	9.97	38	206442	2194	90419773
Inability to afford medication	43.02	9.97	47	206433	3575	90418392
Sepsis	42.21	9.97	609	205871	179205	90242762
Myelosuppression	42.15	9.97	36	206444	53555	90368412
Metabolic alkalosis	42.06	9.97	46	206434	3503	90418464
Hypochloraemia	42.04	9.97	40	206440	2582	90419385
Full blood count abnormal	41.92	9.97	180	206300	36417	90385550
Macular degeneration	41.86	9.97	17	206463	37953	90384014
Atrioventricular block first degree	41.85	9.97	72	206408	8439	90413528
Tachypnoea	41.78	9.97	125	206355	21184	90400783
Lichen planopilaris	41.39	9.97	16	206464	184	90421783
Hypertrichosis	41.17	9.97	31	206449	1448	90420519
Peripheral circulatory failure	41.09	9.97	32	206448	1572	90420395
Incorrect route of product administration	41.06	9.97	33	206447	50593	90371374
Sudden death	40.75	9.97	82	206398	10827	90411140
Walking aid user	40.63	9.97	15	206465	35491	90386476
Lung transplant	40.57	9.97	46	206434	3646	90418321
Bundle branch block left	40.49	9.97	68	206412	7817	90414150
Catheterisation cardiac	40.25	9.97	53	206427	4903	90417064
Hyperglycaemia	39.98	9.97	225	206255	50745	90371222
Hospitalisation	39.85	9.97	457	206023	127643	90294324
Left ventricular dysfunction	39.79	9.97	97	206383	14572	90407395
Sinus bradycardia	39.65	9.97	106	206374	16846	90405121
Catheter placement	39.51	9.97	38	206442	2486	90419481
Acute pulmonary oedema	39.41	9.97	75	206405	9505	90412462
Haemorrhagic disorder	39.30	9.97	26	206454	986	90420981
Eosinophil count increased	39.28	9.97	90	206390	12991	90408976
Bundle branch block right	39.25	9.97	55	206425	5398	90416569
Catheter site erythema	39.22	9.97	52	206428	4842	90417125
Haemoglobin increased	39.06	9.97	65	206415	7416	90414551
Hypertension	38.45	9.97	773	205707	456759	89965208
Hyperthyroidism	38.38	9.97	110	206370	18200	90403767
Purpura	38.27	9.97	96	206384	14682	90407285
Foreign body in reproductive tract	38.04	9.97	27	206453	1150	90420817
Dementia	37.72	9.97	130	206350	23731	90398236
Jugular vein distension	37.48	9.97	26	206454	1067	90420900
Iron deficiency anaemia	37.48	9.97	129	206351	23533	90398434
Foetal exposure during pregnancy	37.45	9.97	26	206454	42949	90379018
Blood aldosterone increased	37.23	9.97	15	206465	194	90421773
Dyspnoea at rest	37.01	9.97	50	206430	4741	90417226
Adverse event	36.90	9.97	140	206340	117278	90304689
Peripartum cardiomyopathy	36.62	9.97	15	206465	203	90421764
Gastric polyps	36.46	9.97	49	206431	4623	90417344
Disability	36.38	9.97	24	206456	40721	90381246
Anaphylactic reaction	36.27	9.97	92	206388	87432	90334535
Joint dislocation	36.23	9.97	29	206451	44553	90377414
Gout	36.04	9.97	102	206378	16757	90405210
Abortion spontaneous	35.99	9.97	42	206438	54014	90367953
Waist circumference increased	35.75	9.97	24	206456	933	90421034
Blood creatine increased	35.66	9.97	60	206420	6907	90415060
Oxygen consumption increased	35.62	9.97	48	206432	4541	90417426
Catheter site discharge	35.34	9.97	35	206445	2374	90419593
Pyrexia	34.80	9.97	1194	205286	659291	89762676
Neuroglycopenia	34.71	9.97	25	206455	1090	90420877
Psoriasis	34.67	9.97	196	206284	147558	90274409
Altered state of consciousness	34.52	9.97	153	206327	31379	90390588
Contusion	34.38	9.97	386	206094	250830	90171137
Cardioversion	34.38	9.97	27	206453	1343	90420624
Cardiac output decreased	34.36	9.97	24	206456	996	90420971
Cyanosis	34.32	9.97	110	206370	19345	90402622
Abdominal cavity drainage	34.23	9.97	18	206462	442	90421525
Chest pain	34.17	9.97	962	205518	318683	90103284
Ear infection	34.10	9.97	67	206413	69708	90352259
Immunodeficiency	34.05	9.97	29	206451	43205	90378762
Nephropathy	34.00	9.97	69	206411	9166	90412801
Peripheral swelling	33.79	9.97	701	205779	412405	90009562
Heart valve incompetence	33.78	9.97	40	206440	3322	90418645
Respiratory distress	33.29	9.97	176	206304	38770	90383197
Pulmonary arterial wedge pressure increased	33.26	9.97	17	206463	393	90421574
Therapeutic product effect incomplete	33.24	9.97	282	206198	193614	90228353
Laryngitis	33.18	9.97	40	206440	50713	90371254
Electrocardiogram QT prolonged	33.05	9.97	280	206200	72176	90349791
Ischaemic cardiomyopathy	32.96	9.97	35	206445	2578	90419389
Parkinsonism	32.95	9.97	88	206392	13977	90407990
Acute myocardial infarction	32.84	9.97	162	206318	34728	90387239
Cardiorenal syndrome	32.50	9.97	24	206456	1088	90420879
Cerebral infarction	32.17	9.97	133	206347	26463	90395504
Hepatomegaly	31.85	9.97	84	206396	13242	90408725
Cirrhosis alcoholic	31.68	9.97	15	206465	292	90421675
Atrial enlargement	31.49	9.97	16	206464	365	90421602
Chronic obstructive pulmonary disease	31.44	9.97	281	206199	73548	90348419
Ventricular hypokinesia	31.43	9.97	49	206431	5292	90416675
Right ventricular dilatation	31.28	9.97	28	206452	1671	90420296
Acidosis	31.18	9.97	81	206399	12655	90409312
Glucose tolerance impaired	31.00	9.97	61	206419	7924	90414043
Hyperuricaemia	30.66	9.97	55	206425	6664	90415303
Renin increased	30.59	9.97	13	206467	194	90421773
Haemorrhage	30.56	9.97	266	206214	69103	90352864
Intra-abdominal fluid collection	30.52	9.97	35	206445	2809	90419158
Aortic stenosis	30.37	9.97	53	206427	6283	90415684
Vascular resistance pulmonary decreased	30.23	9.97	10	206470	70	90421897
Frequent bowel movements	30.20	9.97	52	206428	56883	90365084
Adverse reaction	30.10	9.97	15	206465	29697	90392270
Diffuse large B-cell lymphoma refractory	29.89	9.97	28	206452	1772	90420195
Pulmonary arterial pressure abnormal	29.49	9.97	18	206462	592	90421375
Portal vein thrombosis	29.35	9.97	36	206444	3102	90418865
Bradyarrhythmia	29.34	9.97	32	206448	2429	90419538
Blood pressure abnormal	29.30	9.97	105	206375	19540	90402427
Diarrhoea	29.23	9.97	2501	203979	936689	89485278
Liver transplant	29.16	9.97	31	206449	2286	90419681
Portopulmonary hypertension	29.14	9.97	11	206469	118	90421849
Dizziness postural	29.10	9.97	64	206416	8989	90412978
Upper-airway cough syndrome	28.94	9.97	88	206392	15047	90406920
Foetal death	28.84	9.97	6	206474	20717	90401250
Thermohypoaesthesia	28.81	9.97	11	206469	122	90421845
Dyspnoea paroxysmal nocturnal	28.66	9.97	22	206458	1058	90420909
Therapy non-responder	28.59	9.97	188	206292	136516	90285451
Blood loss anaemia	28.52	9.97	68	206412	10072	90411895
Oedema	28.30	9.97	626	205854	199669	90222298
Vascular access site thrombosis	28.25	9.97	9	206471	55	90421912
Cardiospasm	28.21	9.97	37	206443	3409	90418558
Therapeutic response decreased	28.18	9.97	107	206373	89622	90332345
Pulmonary hypertensive crisis	28.12	9.97	16	206464	461	90421506
Occult blood positive	28.11	9.97	40	206440	3983	90417984
Poor peripheral circulation	28.09	9.97	40	206440	3985	90417982
Cardio-respiratory arrest	27.75	9.97	242	206238	62898	90359069
Bradykinesia	27.75	9.97	53	206427	6735	90415232
Device stimulation issue	27.71	9.97	9	206471	59	90421908
Toxicity to various agents	27.67	9.97	475	206005	287371	90134596
Ischaemic contracture of the left ventricle	27.67	9.97	11	206469	137	90421830
Hepatic cancer	27.64	9.97	44	206436	4837	90417130
N-terminal prohormone brain natriuretic peptide abnormal	27.58	9.97	9	206471	60	90421907
Aortic valve incompetence	27.43	9.97	52	206428	6572	90415395
Presyncope	27.37	9.97	144	206336	31661	90390306
Food allergy	27.14	9.97	12	206468	25466	90396501
Sight disability	27.11	9.97	11	206469	145	90421822
Haemorrhage subcutaneous	27.09	9.97	36	206444	3360	90418607
Device alarm issue	26.94	9.97	27	206453	1858	90420109
Hypertrophic cardiomyopathy	26.62	9.97	29	206451	2199	90419768
Bilirubin conjugated increased	26.24	9.97	34	206446	3096	90418871
Palmoplantar keratoderma	26.18	9.97	36	206444	3471	90418496
Bile acid malabsorption	26.18	9.97	13	206467	282	90421685
Product administration interrupted	26.14	9.97	75	206405	12417	90409550
Haemorrhoidal haemorrhage	26.13	9.97	45	206435	5278	90416689
Loss of consciousness	26.12	9.97	457	206023	139781	90282186
Circulatory collapse	25.89	9.97	119	206361	24785	90397182
Monocytosis	25.83	9.97	20	206460	974	90420993
Chronic hepatic failure	25.76	9.97	17	206463	642	90421325
Pruritus genital	25.69	9.97	41	206439	4517	90417450
Hyperbilirubinaemia	25.69	9.97	80	206400	13856	90408111
Drug-induced liver injury	25.67	9.97	112	206368	90206	90331761
Alanine aminotransferase increased	25.50	9.97	395	206085	117943	90304024
Device related sepsis	25.50	9.97	42	206438	4751	90417216
Diabetes mellitus inadequate control	25.47	9.97	97	206383	18587	90403380
Renal artery stenosis	25.42	9.97	28	206452	2149	90419818
Vascular device infection	25.24	9.97	72	206408	11880	90410087
Right ventricular dysfunction	25.21	9.97	29	206451	2335	90419632
Torsade de pointes	25.13	9.97	84	206396	15098	90406869
Memory impairment	25.08	9.97	308	206172	196936	90225031
Vascular access site infection	25.05	9.97	9	206471	83	90421884
Flushing	25.01	9.97	310	206170	88181	90333786
Embolic stroke	24.86	9.97	38	206442	4034	90417933
Activated partial thromboplastin time prolonged	24.79	9.97	55	206425	7770	90414197
Electrocardiogram abnormal	24.70	9.97	65	206415	10233	90411734
Sputum culture	24.66	9.97	13	206467	321	90421646
Cortisol increased	24.64	9.97	15	206465	491	90421476
Calcium deficiency	24.60	9.97	22	206458	1311	90420656
Marasmus	24.59	9.97	18	206462	805	90421162
Peritonitis bacterial	24.46	9.97	43	206437	5128	90416839
Blood pressure systolic abnormal	24.45	9.97	7	206473	19471	90402496
Transplant evaluation	24.42	9.97	22	206458	1324	90420643
Proctitis	24.42	9.97	3	206477	15256	90406711
Systemic infection	24.28	9.97	41	206439	4734	90417233
Fear of eating	24.15	9.97	14	206466	418	90421549
Cardiac dysfunction	24.01	9.97	35	206445	3562	90418405
Coagulopathy	24.00	9.97	111	206369	23178	90398789
Stupor	23.90	9.97	44	206436	5438	90416529
Spur cell anaemia	23.83	9.97	8	206472	59	90421908
Drug dispensed to wrong patient	23.78	9.97	13	206467	346	90421621
Multimorbidity	23.74	9.97	16	206464	626	90421341
Erysipelas	23.64	9.97	59	206421	8993	90412974
Ear pain	23.64	9.97	61	206419	57641	90364326
Right atrial dilatation	23.58	9.97	17	206463	742	90421225
Catheter site pain	23.35	9.97	44	206436	5535	90416432
Renin decreased	23.32	9.97	9	206471	103	90421864
Drug resistance	23.28	9.97	21	206459	30428	90391539
Burning sensation	23.28	9.97	234	206246	63218	90358749
Ventricular arrhythmia	23.17	9.97	38	206442	4283	90417684
Multiple drug therapy	23.04	9.97	50	206430	6959	90415008
Cardiac hypertrophy	22.85	9.97	20	206460	1158	90420809
Splenomegaly	22.73	9.97	73	206407	12851	90409116
Blood albumin decreased	22.71	9.97	87	206393	16716	90405251
Neck pain	22.69	9.97	159	206321	113804	90308163
Cardiopulmonary failure	22.69	9.97	37	206443	4151	90417816
Catheter removal	22.65	9.97	13	206467	381	90421586
Puncture site haemorrhage	22.52	9.97	13	206467	385	90421582
Walking distance test abnormal	22.46	9.97	15	206465	578	90421389
Multiple sclerosis relapse	22.43	9.97	54	206426	52251	90369716
Injection site erythema	22.39	9.97	132	206348	98370	90323597
Neonatal respiratory failure	22.34	9.97	12	206468	308	90421659
Sinus arrest	22.34	9.97	26	206454	2120	90419847
Sleep terror	22.26	9.97	38	206442	4426	90417541
Vessel puncture site haemorrhage	22.23	9.97	9	206471	118	90421849
Dry skin	22.15	9.97	302	206178	87771	90334196
Vasodilatation	22.13	9.97	30	206450	2854	90419113
Pulmonary veno-occlusive disease	21.92	9.97	22	206458	1516	90420451
Blood glucose increased	21.71	9.97	321	206159	94925	90327042
Asthenia	21.67	9.97	1452	205028	532299	89889668
Brain natriuretic peptide abnormal	21.65	9.97	13	206467	415	90421552
Exercise tolerance decreased	21.63	9.97	51	206429	7500	90414467
Supraventricular tachycardia	21.60	9.97	84	206396	16252	90405715
Aortic valve calcification	21.55	9.97	15	206465	619	90421348
Feeling abnormal	21.55	9.97	516	205964	166719	90255248
Low cardiac output syndrome	21.51	9.97	13	206467	420	90421547
Urinary tract infection	21.49	9.97	876	205604	304756	90117211
Hypernatraemia	21.26	9.97	58	206422	9329	90412638
Muscular weakness	21.18	9.97	337	206143	206329	90215638
Hepatitis	21.16	9.97	86	206394	70653	90351314
Nodal arrhythmia	21.12	9.97	20	206460	1283	90420684
Disseminated intravascular coagulation	20.99	9.97	101	206379	21437	90400530
Azotaemia	20.94	9.97	41	206439	5307	90416660
Left-to-right cardiac shunt	20.89	9.97	11	206469	271	90421696
Amnesia	20.82	9.97	153	206327	108352	90313615
Temperature regulation disorder	20.75	9.97	4	206476	14575	90407392
Aspiration pleural cavity	20.75	9.97	17	206463	899	90421068
Red cell distribution width abnormal	20.74	9.97	10	206470	203	90421764
Tenosynovitis	20.73	9.97	4	206476	14563	90407404
Blood pressure systolic decreased	20.72	9.97	57	206423	9213	90412754
Electrocardiogram change	20.69	9.97	16	206464	778	90421189
Dermatitis contact	20.56	9.97	73	206407	13522	90408445
Viral diarrhoea	20.52	9.97	10	206470	208	90421759
Hypoalbuminaemia	20.42	9.97	81	206399	15816	90406151
Intentional self-injury	20.39	9.97	22	206458	29312	90392655
Hypophagia	20.33	9.97	146	206334	35791	90386176
Inferior vena cava dilatation	20.32	9.97	8	206472	97	90421870
Injection site pain	20.32	9.97	276	206204	173423	90248544
Hyperglycaemic hyperosmolar nonketotic syndrome	20.28	9.97	20	206460	1349	90420618
Lower gastrointestinal haemorrhage	20.19	9.97	55	206425	8837	90413130
Catheter site inflammation	20.09	9.97	17	206463	940	90421027
Pulmonary vascular resistance abnormality	19.96	9.97	8	206472	102	90421865
Venous pressure jugular increased	19.94	9.97	14	206466	586	90421381
Joint effusion	19.89	9.97	10	206470	19700	90402267
Electrocardiogram T wave amplitude increased	19.84	9.97	6	206474	30	90421937
Drug tolerance	19.78	9.97	8	206472	17908	90404059
Septic shock	19.72	9.97	285	206195	83875	90338092
Duodenal ulcer	19.65	9.97	57	206423	9495	90412472
Hypotonia	19.61	9.97	64	206416	11362	90410605
Gastric varices haemorrhage	19.60	9.97	9	206471	163	90421804
Initial insomnia	19.58	9.97	56	206424	9254	90412713
International normalised ratio abnormal	19.53	9.97	33	206447	3812	90418155
Carotid artery occlusion	19.45	9.97	44	206436	6298	90415669
Schizophrenia	19.40	9.97	5	206475	14909	90407058
Brain stem stroke	19.36	9.97	12	206468	406	90421561
Toxic skin eruption	19.17	9.97	79	206401	15695	90406272
Metastases to central nervous system	19.10	9.97	8	206472	17534	90404433
Senile dementia	19.08	9.97	10	206470	244	90421723
Depression	19.06	9.97	530	205950	300071	90121896
Cardiovascular insufficiency	19.04	9.97	21	206459	1614	90420353
Localised oedema	19.02	9.97	43	206437	6151	90415816
Nasal congestion	18.96	9.97	281	206199	83133	90338834
Toxic epidermal necrolysis	18.90	9.97	133	206347	32395	90389572
Nodal rhythm	18.88	9.97	22	206458	1796	90420171
Encephalopathy	18.87	9.97	175	206305	46269	90375698
Therapeutic embolisation	18.82	9.97	10	206470	251	90421716
Catheter site swelling	18.81	9.97	22	206458	1803	90420164
Diet noncompliance	18.79	9.97	12	206468	428	90421539
Pulmonary aplasia	18.79	9.97	5	206475	14	90421953
Portal hypertensive gastropathy	18.77	9.97	17	206463	1030	90420937
Scleroderma	18.71	9.97	43	206437	6218	90415749
Subcutaneous drug absorption impaired	18.69	9.97	4	206476	13541	90408426
Anxiety	18.67	9.97	550	205930	309222	90112745
Dermatitis atopic	18.66	9.97	104	206376	23368	90398599
Decreased appetite	18.56	9.97	1042	205438	375498	90046469
Left ventricular enlargement	18.55	9.97	7	206473	75	90421892
Central venous catheterisation	18.44	9.97	27	206453	2759	90419208
Fatigue	18.43	9.97	2326	204154	1151697	89270270
Female sexual arousal disorder	18.39	9.97	6	206474	40	90421927
Blood potassium abnormal	18.36	9.97	28	206452	2966	90419001
Chest injury	18.36	9.97	23	206457	2025	90419942
Premature labour	18.35	9.97	4	206476	13372	90408595
Sudden cardiac death	18.33	9.97	24	206456	2208	90419759
Cardiac murmur	18.22	9.97	86	206394	18108	90403859
Cardiac failure high output	18.21	9.97	12	206468	452	90421515
Renal injury	18.14	9.97	58	206422	10185	90411782
Bleeding varicose vein	18.07	9.97	11	206469	360	90421607
Respiratory disorder	18.04	9.97	81	206399	64735	90357232
Psychotic disorder	17.99	9.97	27	206453	31203	90390764
Product odour abnormal	17.99	9.97	20	206460	1551	90420416
Hypercapnia	17.95	9.97	44	206436	6633	90415334
Pneumonia	17.93	9.97	1687	204793	636372	89785595
Haemodialysis	17.80	9.97	52	206428	8695	90413272
Left atrial dilatation	17.77	9.97	22	206458	1914	90420053
Catheter site pruritus	17.75	9.97	24	206456	2278	90419689
Hypophosphataemia	17.74	9.97	74	206406	14780	90407187
Gouty arthritis	17.73	9.97	13	206467	583	90421384
Neurological decompensation	17.72	9.97	30	206450	3471	90418496
Neutropenia	17.67	9.97	384	206096	224520	90197447
Ventricular failure	17.67	9.97	11	206469	375	90421592
Tension headache	17.61	9.97	47	206433	7462	90414505
Upper respiratory tract infection	17.61	9.97	197	206283	128121	90293846
Cardiac pacemaker insertion	17.51	9.97	34	206446	4373	90417594
Complication of device insertion	17.50	9.97	58	206422	10378	90411589
Asthma	17.47	9.97	419	206061	241741	90180226
Ventricular extrasystoles	17.41	9.97	68	206412	13182	90408785
Blood chloride decreased	17.37	9.97	42	206438	6277	90415690
Pain in extremity	17.35	9.97	844	205636	449685	89972282
Chronic respiratory failure	17.33	9.97	26	206454	2715	90419252
Eye inflammation	17.27	9.97	48	206432	7803	90414164
Rash vesicular	17.24	9.97	10	206470	18187	90403780
Leukaemic infiltration renal	17.24	9.97	5	206475	21	90421946
General symptom	17.12	9.97	6	206474	14662	90407305
Angina unstable	17.05	9.97	45	206435	7098	90414869
Sleep disorder due to a general medical condition	16.90	9.97	166	206314	44572	90377395
Blood bilirubin unconjugated increased	16.89	9.97	11	206469	406	90421561
Haemodynamic instability	16.88	9.97	62	206418	11677	90410290
Asterixis	16.85	9.97	20	206460	1665	90420302
Oligohydramnios	16.81	9.97	45	206435	7156	90414811
Cardiac ablation	16.67	9.97	20	206460	1684	90420283
Myocardial ischaemia	16.64	9.97	69	206411	13745	90408222
Faeces discoloured	16.64	9.97	94	206386	21226	90400741
Hypertonic bladder	16.62	9.97	33	206447	4315	90417652
Primary biliary cholangitis	16.62	9.97	18	206462	1356	90420611
Labelled drug-drug interaction issue	16.59	9.97	23	206457	2235	90419732
Hyperlipidaemia	16.56	9.97	99	206381	22817	90399150
Pustular psoriasis	16.47	9.97	11	206469	18545	90403422
Stevens-Johnson syndrome	16.42	9.97	119	206361	29257	90392710
Upper respiratory tract inflammation	16.40	9.97	25	206455	2647	90419320
Hypocalcaemia	16.39	9.97	158	206322	42210	90379757
Chronic sinusitis	16.38	9.97	18	206462	23784	90398183
Cytomegalovirus infection	16.32	9.97	22	206458	26580	90395387
Atrial septal defect repair	16.28	9.97	9	206471	245	90421722
Endocarditis	16.16	9.97	44	206436	7069	90414898
Renal tubular acidosis	16.15	9.97	23	206457	2292	90419675
Urine output increased	16.13	9.97	20	206460	1742	90420225
Tachycardia	16.13	9.97	472	206008	157201	90264766
Maternal exposure before pregnancy	16.12	9.97	3	206477	11210	90410757
Gastroenteritis	16.11	9.97	118	206362	29111	90392856
Intestinal haemorrhage	16.10	9.97	33	206447	4414	90417553
Pallor	16.10	9.97	133	206347	34032	90387935
Liver function test abnormal	16.08	9.97	182	206298	50663	90371304
Blood parathyroid hormone decreased	16.07	9.97	4	206476	12212	90409755
Blood pressure diastolic abnormal	16.07	9.97	13	206467	19868	90402099
Rales	15.99	9.97	75	206405	15752	90406215
Mixed hepatocellular cholangiocarcinoma	15.97	9.97	4	206476	8	90421959
Gastric antral vascular ectasia	15.93	9.97	14	206466	815	90421152
Cardiac cirrhosis	15.93	9.97	8	206472	178	90421789
Hepatorenal failure	15.92	9.97	13	206467	684	90421283
Amaurosis	15.92	9.97	14	206466	816	90421151
Malignant ascites	15.91	9.97	15	206465	957	90421010
Insomnia	15.89	9.97	610	205870	332864	90089103
Gastrointestinal arteriovenous malformation	15.89	9.97	12	206468	563	90421404
Flatulence	15.88	9.97	154	206326	41213	90380754
Blood uric acid increased	15.87	9.97	46	206434	7658	90414309
Puncture site haematoma	15.84	9.97	6	206474	65	90421902
Pericarditis constrictive	15.83	9.97	12	206468	566	90421401
Oesophageal variceal ligation	15.77	9.97	5	206475	30	90421937
Dilatation ventricular	15.69	9.97	23	206457	2353	90419614
Alcoholic liver disease	15.65	9.97	7	206473	119	90421848
Mitral valve disease	15.63	9.97	24	206456	2558	90419409
Right ventricular systolic pressure increased	15.52	9.97	12	206468	583	90421384
Catheter site haemorrhage	15.44	9.97	29	206451	3639	90418328
Postpericardiotomy syndrome	15.36	9.97	4	206476	10	90421957
Product administration error	15.33	9.97	108	206372	26315	90395652
Simple partial seizures	15.32	9.97	13	206467	722	90421245
Intestinal varices haemorrhage	15.26	9.97	3	206477	0	90421967
Bone density decreased	15.25	9.97	79	206401	17266	90404701
Catastrophic reaction	15.24	9.97	5	206475	34	90421933
Brain natriuretic peptide	15.24	9.97	5	206475	34	90421933
Gastric ulcer	15.23	9.97	111	206369	27337	90394630
Facial pain	15.22	9.97	65	206415	13117	90408850
Adrenal adenoma	15.21	9.97	16	206464	1166	90420801
Cardiac valve disease	15.16	9.97	33	206447	4602	90417365
Cardiac flutter	15.15	9.97	33	206447	4605	90417362
Angina pectoris	15.13	9.97	146	206334	39014	90382953
Suicide attempt	15.11	9.97	105	206375	75294	90346673
Panniculitis	15.10	9.97	7	206473	14451	90407516
Radiculopathy	15.08	9.97	12	206468	18493	90403474
Peripheral artery occlusion	15.07	9.97	18	206462	1508	90420459
Nephrogenic anaemia	15.04	9.97	23	206457	2443	90419524
Bronchopulmonary dysplasia	15.02	9.97	12	206468	612	90421355
No adverse event	14.97	9.97	92	206388	67890	90354077
Subchorionic haematoma	14.94	9.97	7	206473	133	90421834
Dystonia	14.89	9.97	10	206470	16809	90405158
Primary hyperaldosteronism	14.86	9.97	6	206474	78	90421889
Product used for unknown indication	14.84	9.97	13	206467	754	90421213
Agranulocytosis	14.78	9.97	133	206347	34869	90387098
International normalised ratio decreased	14.74	9.97	33	206447	4691	90417276
Euglycaemic diabetic ketoacidosis	14.73	9.97	39	206441	6162	90415805
Normal newborn	14.66	9.97	19	206461	23343	90398624
Volume blood decreased	14.60	9.97	8	206472	214	90421753
Gastritis erosive	14.57	9.97	41	206439	6714	90415253
Drug monitoring procedure not performed	14.55	9.97	13	206467	774	90421193
Chronic right ventricular failure	14.54	9.97	5	206475	40	90421927
Blood urea abnormal	14.50	9.97	14	206466	920	90421047
Diarrhoea infectious	14.48	9.97	16	206464	1233	90420734
Prothrombin time abnormal	14.47	9.97	11	206469	521	90421446
Product substitution issue	14.45	9.97	80	206400	17928	90404039
Sensory loss	14.39	9.97	12	206468	18063	90403904
Coma hepatic	14.33	9.97	12	206468	654	90421313
Traumatic haematoma	14.27	9.97	19	206461	1776	90420191
Haematocrit abnormal	14.27	9.97	15	206465	1092	90420875
Depressed level of consciousness	14.20	9.97	239	206241	72545	90349422
Toxic neuropathy	14.18	9.97	11	206469	537	90421430
Bronchiectasis	14.18	9.97	18	206462	22312	90399655
Unevaluable event	14.17	9.97	189	206291	54659	90367308
Deformity	14.16	9.97	5	206475	12165	90409802
Pancreatic enzymes decreased	14.15	9.97	4	206476	15	90421952
Hyperaldosteronism	14.09	9.97	9	206471	321	90421646
Infusion site pain	14.09	9.97	85	206395	19653	90402314
Ulcer	14.06	9.97	34	206446	32848	90389119
Akathisia	14.03	9.97	4	206476	11155	90410812
Emergency care examination	14.01	9.97	7	206473	154	90421813
Drug reaction with eosinophilia and systemic symptoms	13.95	9.97	154	206326	42604	90379363
Blood catecholamines decreased	13.95	9.97	4	206476	16	90421951
Staphylococcal sepsis	13.86	9.97	50	206430	9333	90412634
Hepatitis C	13.86	9.97	36	206444	5624	90416343
Pulmonary haemorrhage	13.86	9.97	45	206435	7968	90413999
Acute on chronic liver failure	13.85	9.97	9	206471	331	90421636
Drug therapeutic incompatibility	13.83	9.97	5	206475	47	90421920
Sedation complication	13.80	9.97	11	206469	16933	90405034
Neuromyelitis optica spectrum disorder	13.78	9.97	17	206463	1473	90420494
Walking disability	13.74	9.97	17	206463	1478	90420489
Strabismus	13.64	9.97	22	206458	2446	90419521
Polyarthritis	13.62	9.97	13	206467	18337	90403630
Neurodevelopmental disorder	13.62	9.97	8	206472	245	90421722
Catheter site abscess	13.56	9.97	8	206472	247	90421720
Glomerular filtration rate abnormal	13.51	9.97	16	206464	1329	90420638
Cerebral haemorrhage	13.49	9.97	129	206351	34393	90387574
Ectopic ACTH syndrome	13.35	9.97	7	206473	171	90421796
Coronary artery disease	13.31	9.97	126	206354	33497	90388470
Catheter site scab	13.30	9.97	8	206472	256	90421711
Hepatic hydrothorax	13.30	9.97	5	206475	53	90421914
Pain of skin	13.28	9.97	72	206408	16010	90405957
Urogenital haemorrhage	13.22	9.97	8	206472	259	90421708
Palliative care	13.21	9.97	13	206467	875	90421092
Platelet dysfunction	13.20	9.97	6	206474	106	90421861
Ulcer haemorrhage	13.10	9.97	25	206455	26296	90395671
Duodenal ulcer haemorrhage	13.07	9.97	22	206458	2534	90419433
Pulmonary arteriovenous fistula	13.06	9.97	4	206476	21	90421946
CREST syndrome	13.04	9.97	11	206469	606	90421361
Left ventricular hypertrophy	12.96	9.97	37	206443	6107	90415860
Progressive multifocal leukoencephalopathy	12.95	9.97	10	206470	15645	90406322
Lip erosion	12.89	9.97	15	206465	1223	90420744
Neuropathy peripheral	12.84	9.97	227	206253	136743	90285224
Dilatation atrial	12.82	9.97	19	206461	1962	90420005
Thromboembolectomy	12.82	9.97	5	206475	59	90421908
Hepatitis fulminant	12.81	9.97	28	206452	3917	90418050
Mucocutaneous haemorrhage	12.81	9.97	6	206474	114	90421853
Cardiac operation	12.79	9.97	28	206452	3921	90418046
Urine potassium increased	12.76	9.97	4	206476	23	90421944
Extensor plantar response	12.75	9.97	16	206464	1411	90420556
Neonatal hyponatraemia	12.75	9.97	5	206475	60	90421907
Blood antidiuretic hormone increased	12.73	9.97	3	206477	4	90421963
Dermoid cyst	12.72	9.97	10	206470	498	90421469
Subarachnoid haemorrhage	12.72	9.97	77	206403	17827	90404140
Cytokine release syndrome	12.71	9.97	28	206452	27945	90394022
Electrocardiogram QT shortened	12.68	9.97	7	206473	190	90421777
Immunisation	12.60	9.97	20	206460	2193	90419774
Anticoagulation drug level above therapeutic	12.53	9.97	19	206461	2003	90419964
Urine glucose/creatinine ratio increased	12.51	9.97	7	206473	195	90421772
Blood culture negative	12.51	9.97	7	206473	195	90421772
Foetal growth restriction	12.48	9.97	3	206477	9377	90412590
Ventricular assist device insertion	12.48	9.97	4	206476	25	90421942
Infusion site reaction	12.45	9.97	15	206465	19024	90402943
Malignant neoplasm progression	12.42	9.97	170	206310	106700	90315267
Head injury	12.41	9.97	117	206363	31071	90390896
Exposure to SARS-CoV-2	12.40	9.97	21	206459	2431	90419536
Haematoma muscle	12.35	9.97	18	206462	1832	90420135
Portal shunt	12.35	9.97	4	206476	26	90421941
Left ventricular dilatation	12.32	9.97	11	206469	654	90421313
Cardiac ventricular thrombosis	12.24	9.97	14	206466	1120	90420847
Right ventricular hypertrophy	12.23	9.97	12	206468	805	90421162
Incision site impaired healing	12.23	9.97	9	206471	406	90421561
Catheter site rash	12.19	9.97	12	206468	808	90421159
Nocturia	12.18	9.97	51	206429	10204	90411763
Renal function test abnormal	12.09	9.97	40	206440	7151	90414816
Cutaneous vasculitis	12.08	9.97	40	206440	7153	90414814
Gamma-glutamyltransferase abnormal	12.07	9.97	10	206470	537	90421430
Staphylococcus test positive	12.07	9.97	29	206451	4316	90417651
Listeraemia	12.05	9.97	5	206475	70	90421897
Treatment noncompliance	12.05	9.97	175	206305	51552	90370415
Hypomagnesaemia	11.99	9.97	129	206351	35459	90386508
Device connection issue	11.96	9.97	13	206467	983	90420984
Stress	11.95	9.97	123	206357	81272	90340695
Blood glucose abnormal	11.90	9.97	48	206432	9444	90412523
Productive cough	11.89	9.97	244	206236	76819	90345148
Abdominal pain upper	11.88	9.97	628	205852	332046	90089921
Pulseless electrical activity	11.87	9.97	46	206434	8886	90413081
Tachyarrhythmia	11.84	9.97	33	206447	5373	90416594
Ventricular dyssynchrony	11.80	9.97	5	206475	74	90421893
Electrocardiogram T wave inversion	11.80	9.97	26	206454	3657	90418310
Coordination abnormal	11.79	9.97	19	206461	21337	90400630
Nasal polyps	11.78	9.97	5	206475	10875	90411092
Injection site pruritus	11.78	9.97	73	206407	53761	90368206
Ulcerative keratitis	11.77	9.97	25	206455	3428	90418539
Heart sounds abnormal	11.77	9.97	11	206469	694	90421273
Periumbilical abscess	11.75	9.97	7	206473	220	90421747
Visual acuity reduced transiently	11.75	9.97	7	206473	220	90421747
Gastrointestinal angiectasia	11.74	9.97	5	206475	75	90421892
Anosmia	11.71	9.97	49	206431	9799	90412168
Haemorrhagic stroke	11.70	9.97	37	206443	6459	90415508
Wrong patient received product	11.65	9.97	25	206455	3452	90418515
Ballismus	11.65	9.97	6	206474	141	90421826
Hyperplasia adrenal	11.63	9.97	4	206476	32	90421935
Iliac artery stenosis	11.62	9.97	5	206475	77	90421890
Hypoosmolar state	11.59	9.97	7	206473	226	90421741
Diabetic metabolic decompensation	11.58	9.97	18	206462	1939	90420028
Pancreatitis acute	11.57	9.97	118	206362	31997	90389970
Defect conduction intraventricular	11.50	9.97	7	206473	229	90421738
Protein-losing gastroenteropathy	11.50	9.97	8	206472	330	90421637
Premature baby	11.47	9.97	25	206455	25052	90396915
Balloon atrial septostomy	11.45	9.97	5	206475	80	90421887
Throat tightness	11.45	9.97	32	206448	29452	90392515
Myalgia	11.40	9.97	498	205982	174627	90247340
Hypoperfusion	11.39	9.97	17	206463	1767	90420200
Petechiae	11.37	9.97	68	206412	15673	90406294
Hepatic neoplasm	11.34	9.97	19	206461	2179	90419788
Nephrocalcinosis	11.31	9.97	14	206466	1218	90420749
Hypertensive heart disease	11.27	9.97	21	206459	2619	90419348
QRS axis abnormal	11.25	9.97	14	206466	1224	90420743
Acute right ventricular failure	11.24	9.97	7	206473	239	90421728
Cerebral ischaemia	11.19	9.97	39	206441	7157	90414810
Immobilisation syndrome	11.18	9.97	9	206471	464	90421503
Respiratory tract infection	11.16	9.97	193	206287	58885	90363082
Infusion site erythema	11.15	9.97	61	206419	13609	90408358
Fibrinous bronchitis	11.12	9.97	3	206477	9	90421958
Haemoconcentration	11.10	9.97	6	206474	156	90421811
Chloasma	11.10	9.97	6	206474	156	90421811
Atrial thrombosis	11.05	9.97	19	206461	2226	90419741
Clostridium difficile colitis	11.04	9.97	101	206379	26605	90395362
Percutaneous coronary intervention	11.03	9.97	7	206473	247	90421720
Device dislocation	11.02	9.97	115	206365	31367	90390600
Hypoproteinaemia	11.01	9.97	23	206457	3119	90418848
Peripheral artery stenosis	10.99	9.97	10	206470	610	90421357
Colitis	10.98	9.97	104	206376	69838	90352129
Impaired quality of life	10.85	9.97	90	206390	23054	90398913
Cardiac valve thickening	10.85	9.97	4	206476	40	90421927
Gastrointestinal endoscopic therapy	10.85	9.97	4	206476	40	90421927
Blood pressure systolic increased	10.84	9.97	83	206397	58262	90363705
Interstitial lung disease	10.84	9.97	239	206241	76166	90345801
Blood magnesium decreased	10.84	9.97	67	206413	15626	90406341
Bundle branch block	10.83	9.97	12	206468	927	90421040
Electrocardiogram T wave peaked	10.81	9.97	7	206473	256	90421711
Yawning	10.79	9.97	13	206467	1099	90420868
Photophobia	10.76	9.97	20	206460	21249	90400718
Muscle twitching	10.76	9.97	93	206387	24109	90397858
Acute left ventricular failure	10.74	9.97	14	206466	1282	90420685
Chronic left ventricular failure	10.74	9.97	10	206470	628	90421339
Thrombotic microangiopathy	10.73	9.97	12	206468	15731	90406236
Deep vein thrombosis	10.70	9.97	279	206201	91341	90330626
Anal haemorrhage	10.68	9.97	20	206460	2504	90419463
Respiratory alkalosis	10.66	9.97	24	206456	3424	90418543
Dry gangrene	10.65	9.97	10	206470	635	90421332
External ear disorder	10.59	9.97	4	206476	43	90421924
Blood aldosterone abnormal	10.59	9.97	4	206476	43	90421924
Spondylitis	10.58	9.97	10	206470	14168	90407799
Face oedema	10.57	9.97	90	206390	23228	90398739
Thyroxine increased	10.46	9.97	11	206469	801	90421166
Somatostatin receptor scan abnormal	10.46	9.97	3	206477	12	90421955
Gonadotrophin deficiency	10.46	9.97	3	206477	12	90421955
Posterior reversible encephalopathy syndrome	10.45	9.97	22	206458	22317	90399650
Colon cancer	10.43	9.97	51	206429	10893	90411074
Pancreatolithiasis	10.43	9.97	7	206473	272	90421695
Femoral artery embolism	10.43	9.97	4	206476	45	90421922
Metastases to bone	10.42	9.97	27	206453	25478	90396489
Blood electrolytes abnormal	10.37	9.97	13	206467	1145	90420822
Platelet disorder	10.37	9.97	19	206461	2340	90419627
Conduction disorder	10.32	9.97	16	206464	1719	90420248
Vascular purpura	10.30	9.97	16	206464	1722	90420245
Alpha 1 foetoprotein increased	10.27	9.97	6	206474	182	90421785
Heparin-induced thrombocytopenia	10.26	9.97	31	206449	5281	90416686
Dialysis	10.24	9.97	52	206428	11277	90410690
Vascular stenosis	10.20	9.97	9	206471	527	90421440
Thrombosis in device	10.18	9.97	22	206458	3053	90418914
Right-to-left cardiac shunt	10.14	9.97	7	206473	285	90421682
Device occlusion	10.13	9.97	45	206435	9237	90412730
Hypocalvaria	10.12	9.97	4	206476	49	90421918
Oligodipsia	10.12	9.97	4	206476	49	90421918
Lethargy	10.10	9.97	201	206279	62938	90359029
Spinal fusion surgery	9.97	9.97	8	206472	12275	90409692

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperkalaemia	3075.42	10.82	2420	147246	78038	42393631
Acute kidney injury	1210.12	10.82	3410	146256	363927	42107742
Cardiac failure	900.09	10.82	1458	148208	105398	42366271
Hepatic encephalopathy	635.59	10.82	499	149167	15943	42455726
Hypotension	420.87	10.82	1904	147762	255727	42215942
Cardiac failure chronic	407.32	10.82	308	149358	9293	42462376
Ascites	398.01	10.82	714	148952	55964	42415705
Cardiac failure congestive	370.22	10.82	883	148783	84719	42386950
Drug ineffective	367.64	10.82	1073	148593	629124	41842545
Hyponatraemia	320.64	10.82	931	148735	100531	42371138
Hepatic cirrhosis	299.93	10.82	358	149308	19344	42452325
Oedema peripheral	295.48	10.82	1099	148567	134977	42336692
Gynaecomastia	279.81	10.82	279	149387	12288	42459381
Renal impairment	249.06	10.82	902	148764	109326	42362343
Hepatic failure	240.99	10.82	459	149207	37641	42434028
Dyspnoea	236.90	10.82	2482	147184	440139	42031530
Off label use	231.37	10.82	1309	148357	637026	41834643
Dehydration	230.97	10.82	1048	148618	140719	42330950
Drug abuse	228.70	10.82	45	149621	104726	42366943
Pulmonary hypertension	226.23	10.82	342	149324	23227	42448442
Ejection fraction decreased	209.87	10.82	319	149347	21768	42449901
Blood potassium increased	205.57	10.82	288	149378	18248	42453421
Right ventricular failure	205.13	10.82	208	149458	9347	42462322
N-terminal prohormone brain natriuretic peptide increased	183.48	10.82	127	149539	3326	42468343
Febrile neutropenia	181.97	10.82	231	149435	185472	42286197
Blood creatinine increased	167.84	10.82	798	148868	109205	42362464
Ventricular tachycardia	167.36	10.82	344	149322	29816	42441853
Completed suicide	166.69	10.82	65	149601	96400	42375269
Oesophageal varices haemorrhage	160.29	10.82	119	149547	3488	42468181
Renal failure	159.43	10.82	955	148711	142771	42328898
Drug interaction	157.05	10.82	1528	148138	265471	42206198
Hepatorenal syndrome	154.07	10.82	106	149560	2748	42468921
Pulmonary arterial hypertension	153.20	10.82	184	149482	10003	42461666
Congestive cardiomyopathy	153.10	10.82	171	149495	8593	42463076
Neutropenia	150.82	10.82	295	149371	199136	42272533
Toxicity to various agents	146.26	10.82	372	149294	228764	42242905
Cardiac failure acute	144.04	10.82	207	149459	13426	42458243
BRASH syndrome	143.75	10.82	86	149580	1739	42469930
Bradycardia	143.59	10.82	638	149028	84846	42386823
International normalised ratio increased	138.71	10.82	428	149238	47740	42423929
Mitral valve incompetence	134.35	10.82	222	149444	16267	42455402
Orthopnoea	131.29	10.82	126	149540	5291	42466378
Hepatocellular carcinoma	128.16	10.82	151	149515	8043	42463626
Orthostatic hypotension	124.12	10.82	308	149358	30262	42441407
Blood urea increased	121.33	10.82	319	149347	32474	42439195
Oedema	120.23	10.82	429	149237	51572	42420097
Atrial fibrillation	119.22	10.82	869	148797	138724	42332945
Therapeutic product effect incomplete	115.77	10.82	52	149614	70887	42400782
Brain natriuretic peptide increased	114.68	10.82	130	149536	6640	42465029
Syncope	112.36	10.82	664	149002	98742	42372927
Ischaemic cardiomyopathy	110.07	10.82	125	149541	6397	42465272
Chronic kidney disease	108.59	10.82	389	149277	46852	42424817
Arthralgia	108.49	10.82	364	149302	204874	42266795
Hepatic cancer	104.98	10.82	139	149527	8341	42463328
Product use in unapproved indication	103.86	10.82	318	149348	184138	42287531
General physical health deterioration	98.43	10.82	885	148781	150361	42321308
Hypokalaemia	97.01	10.82	503	149163	71218	42400451
Dyspnoea exertional	96.35	10.82	390	149276	49758	42421911
Varices oesophageal	95.48	10.82	96	149570	4269	42467400
Fluid retention	94.80	10.82	285	149381	31334	42440335
Atrioventricular block complete	91.23	10.82	152	149514	11212	42460457
Intentional product misuse	85.50	10.82	56	149610	61844	42409825
Intentional overdose	83.51	10.82	38	149628	51418	42420251
Treatment failure	83.37	10.82	59	149607	62565	42409104
Glomerular filtration rate decreased	83.14	10.82	180	149486	16171	42455498
Tricuspid valve incompetence	83.07	10.82	144	149522	10969	42460700
Gastrointestinal haemorrhage	82.58	10.82	607	149059	97119	42374550
Foetal exposure during pregnancy	81.49	10.82	32	149634	47279	42424390
Pyrexia	79.76	10.82	943	148723	393099	42078570
Bundle branch block left	78.39	10.82	105	149561	6371	42465298
Arrhythmia	76.21	10.82	312	149354	40005	42431664
Intentional product use issue	74.88	10.82	85	149581	71748	42399921
Blood pressure decreased	74.69	10.82	403	149263	57929	42413740
Fall	72.78	10.82	1192	148474	233328	42238341
Pain	70.85	10.82	536	149130	244312	42227357
Breast tenderness	69.73	10.82	41	149625	802	42470867
Rash	68.96	10.82	631	149035	276323	42195346
Melaena	68.67	10.82	294	149372	38452	42433217
Electrolyte imbalance	65.96	10.82	169	149497	16932	42454737
Blood bilirubin increased	64.69	10.82	307	149359	41945	42429724
Suicide attempt	64.63	10.82	41	149625	46059	42425610
Anxiety	64.13	10.82	208	149458	118352	42353317
Cardiomegaly	63.95	10.82	165	149501	16601	42455068
Ammonia increased	63.35	10.82	80	149586	4579	42467090
Infusion related reaction	63.32	10.82	72	149594	60734	42410935
Neuropathy peripheral	62.84	10.82	168	149498	101685	42369984
Electrocardiogram abnormal	62.60	10.82	121	149545	10024	42461645
Hypovolaemia	62.51	10.82	130	149536	11355	42460314
Hypervolaemia	61.52	10.82	200	149466	22925	42448744
Concomitant disease aggravated	60.96	10.82	94	149572	6492	42465177
Depression	59.11	10.82	197	149469	111166	42360503
COVID-19	58.25	10.82	210	149456	115738	42355931
Rheumatoid arthritis	57.79	10.82	39	149627	42401	42429268
Left ventricular dysfunction	57.77	10.82	126	149540	11375	42460294
Cardiac amyloidosis	57.03	10.82	51	149615	1954	42469715
Drug dependence	56.53	10.82	16	149650	29078	42442591
Suicidal ideation	55.84	10.82	52	149614	48109	42423560
Nipple pain	55.46	10.82	39	149627	1048	42470621
Injection site pain	55.37	10.82	73	149593	57725	42413944
Blood cholesterol	53.90	10.82	23	149643	217	42471452
Cardiomyopathy	53.70	10.82	169	149497	19041	42452628
Stress	52.13	10.82	47	149619	44165	42427504
Brain natriuretic peptide abnormal	51.91	10.82	26	149640	364	42471305
Congestive hepatopathy	51.39	10.82	52	149614	2330	42469339
Musculoskeletal stiffness	51.31	10.82	77	149589	57688	42413981
Jaundice	51.26	10.82	249	149417	34340	42437329
Urticaria	51.25	10.82	115	149551	73921	42397748
Breast pain	50.21	10.82	43	149623	1554	42470115
Atrioventricular block	50.20	10.82	107	149559	9508	42462161
Left ventricular dilatation	49.73	10.82	34	149632	872	42470797
Cytokine release syndrome	49.39	10.82	50	149616	44477	42427192
Glomerular filtration rate abnormal	49.23	10.82	38	149628	1182	42470487
Product dose omission issue	48.94	10.82	329	149337	154036	42317633
Loss of personal independence in daily activities	48.66	10.82	62	149604	49754	42421915
Pulmonary embolism	48.09	10.82	236	149430	119376	42352293
Anaemia	47.72	10.82	1305	148361	278973	42192696
Mucosal inflammation	47.66	10.82	62	149604	49312	42422357
Headache	47.09	10.82	576	149090	238793	42232876
Leukopenia	47.07	10.82	122	149544	74624	42397045
Thrombosis	46.95	10.82	107	149559	68404	42403265
Overdose	46.89	10.82	200	149466	105064	42366605
Low cardiac output syndrome	46.84	10.82	29	149637	625	42471044
Drug ineffective for unapproved indication	46.62	10.82	56	149610	46107	42425562
Sinusitis	46.05	10.82	59	149607	47233	42424436
Nodal rhythm	45.74	10.82	41	149625	1576	42470093
Seizure	45.56	10.82	243	149423	120318	42351351
Cytomegalovirus infection	44.91	10.82	29	149637	32277	42439392
Therapeutic drug monitoring analysis not performed	44.74	10.82	27	149639	555	42471114
Ventricular internal diameter abnormal	44.55	10.82	19	149647	179	42471490
Systemic infection	43.63	10.82	71	149595	5134	42466535
Therapeutic product effect decreased	43.38	10.82	44	149622	39106	42432563
Lactic acidosis	42.79	10.82	289	149377	44972	42426697
Metabolic acidosis	42.01	10.82	319	149347	51539	42420130
Intentional self-injury	41.75	10.82	3	149663	15199	42456470
Hyperhidrosis	41.53	10.82	170	149496	90342	42381327
Neuroleptic malignant syndrome	41.36	10.82	12	149654	21460	42450209
Joint swelling	41.33	10.82	113	149553	67909	42403760
Portal hypertension	41.09	10.82	66	149600	4721	42466948
Pulmonary congestion	40.90	10.82	135	149531	15595	42456074
Polyuria	40.76	10.82	101	149565	9910	42461759
Pneumonitis	40.67	10.82	52	149614	41666	42430003
Arthropathy	40.56	10.82	27	149639	29570	42442099
Pulmonary arterial pressure abnormal	40.41	10.82	21	149645	319	42471350
Blood sodium decreased	40.39	10.82	148	149518	18014	42453655
Electrocardiogram T wave peaked	40.29	10.82	28	149638	738	42470931
Synovitis	40.21	10.82	4	149662	15563	42456106
Sedation	40.17	10.82	29	149637	30446	42441223
Anuria	39.44	10.82	109	149557	11423	42460246
Generalised oedema	39.32	10.82	131	149535	15205	42456464
Myelosuppression	38.86	10.82	51	149615	40410	42431259
Appendicitis	38.83	10.82	12	149654	20601	42451068
Gastrointestinal disorder	38.77	10.82	65	149601	46588	42425081
Bradyarrhythmia	38.08	10.82	47	149619	2628	42469041
Cardioactive drug level increased	37.62	10.82	38	149628	1699	42469970
White blood cell count decreased	37.15	10.82	231	149435	110165	42361504
Chronic hepatic failure	36.85	10.82	25	149641	633	42471036
Product monitoring error	36.63	10.82	60	149606	4363	42467306
Type 2 diabetes mellitus	36.53	10.82	145	149521	18326	42453343
Left ventricular failure	36.08	10.82	71	149595	5960	42465709
Pulmonary oedema	35.75	10.82	314	149352	52958	42418711
Ventricular hypokinesia	35.24	10.82	76	149590	6808	42464861
Amyloidosis	35.24	10.82	43	149623	2376	42469293
Cardiogenic shock	35.16	10.82	230	149436	35410	42436259
Accidental exposure to product	34.77	10.82	14	149652	20379	42451290
Liver transplant	34.69	10.82	45	149621	2646	42469023
Hepatic function abnormal	34.63	10.82	304	149362	51263	42420406
Abdominal cavity drainage	34.61	10.82	21	149645	436	42471233
Tremor	34.09	10.82	200	149466	96729	42374940
Waist circumference increased	34.04	10.82	28	149638	956	42470713
Cirrhosis alcoholic	34.04	10.82	26	149640	796	42470873
Renin increased	33.97	10.82	16	149650	194	42471475
Somnolence	33.53	10.82	325	149341	140780	42330889
Blood potassium abnormal	33.18	10.82	36	149630	1750	42469919
Hypersensitivity	33.15	10.82	136	149530	72234	42399435
Pleural effusion	33.12	10.82	502	149164	96664	42375005
Neutrophil count decreased	33.07	10.82	113	149553	63302	42408367
Inability to afford medication	32.89	10.82	39	149627	2091	42469578
Subarachnoid haemorrhage	32.24	10.82	118	149548	14354	42457315
Troponin T increased	32.02	10.82	44	149622	2736	42468933
Genitalia external ambiguous	31.94	10.82	16	149650	224	42471445
Nasopharyngitis	31.89	10.82	169	149497	83827	42387842
Urine output decreased	31.63	10.82	97	149569	10776	42460893
Anaphylactic reaction	31.57	10.82	64	149602	42679	42428990
Sleep disorder due to a general medical condition	31.40	10.82	11	149655	17442	42454227
Arthritis	31.05	10.82	63	149603	42002	42429667
Malignant neoplasm progression	30.95	10.82	238	149428	108162	42363507
Oliguria	30.84	10.82	87	149579	9226	42462443
Upper gastrointestinal haemorrhage	30.78	10.82	197	149469	30102	42441567
Dyspnoea paroxysmal nocturnal	30.71	10.82	33	149633	1587	42470082
Colitis ulcerative	30.65	10.82	28	149638	26147	42445522
Iron deficiency anaemia	30.48	10.82	108	149558	12931	42458738
Diastolic dysfunction	30.08	10.82	72	149594	6911	42464758
Dizziness	29.90	10.82	1113	148553	248141	42223528
Portal hypertensive gastropathy	29.70	10.82	24	149642	799	42470870
Cardiac disorder	29.58	10.82	282	149384	48650	42423019
Adverse drug reaction	29.43	10.82	54	149612	37380	42434289
Pain in extremity	29.35	10.82	363	149303	150241	42321428
Myasthenia gravis	29.33	10.82	10	149656	16127	42455542
Multiple sclerosis relapse	29.32	10.82	7	149659	14257	42457412
Jugular vein distension	29.13	10.82	22	149644	662	42471007
Hepatitis C	29.11	10.82	90	149576	10043	42461626
Bronchopulmonary aspergillosis	29.03	10.82	16	149650	19413	42452256
N-terminal prohormone brain natriuretic peptide abnormal	28.97	10.82	15	149651	226	42471443
Chronic obstructive pulmonary disease	28.92	10.82	344	149322	62770	42408899
Keratoconus	28.72	10.82	13	149653	143	42471526
Sudden death	28.55	10.82	125	149541	16504	42455165
Incorrect route of product administration	28.46	10.82	26	149640	24279	42447390
Hallucination	28.30	10.82	105	149561	57402	42414267
Insomnia	28.24	10.82	272	149394	117981	42353688
Sopor	28.10	10.82	6	149660	13196	42458473
Paraesthesia	27.77	10.82	148	149518	73311	42398358
5-alpha-reductase deficiency	27.76	10.82	7	149659	7	42471662
Drug intolerance	27.72	10.82	167	149499	80257	42391412
Cardiac arrest	27.55	10.82	538	149128	108782	42362887
Respiratory depression	27.53	10.82	16	149650	18852	42452817
Graft versus host disease	27.25	10.82	6	149660	12919	42458750
Death	26.86	10.82	1367	148299	469818	42001851
Therapeutic response decreased	26.84	10.82	56	149610	36956	42434713
Premature baby	26.83	10.82	25	149641	23128	42448541
Pemphigoid	26.82	10.82	95	149571	11372	42460297
Adrenal adenoma	26.78	10.82	19	149647	518	42471151
Blood urea abnormal	26.69	10.82	26	149640	1112	42470557
Therapy partial responder	26.45	10.82	19	149647	20002	42451667
Akathisia	26.19	10.82	3	149663	10448	42461221
Prothrombin time prolonged	26.19	10.82	83	149583	9386	42462283
Neutrophil count increased	25.90	10.82	19	149647	19785	42451884
Bone marrow failure	25.78	10.82	48	149618	33045	42438624
Blood loss anaemia	25.71	10.82	84	149582	9652	42462017
Diaphragmatic spasm	25.66	10.82	11	149655	105	42471564
Hyperphosphataemia	25.54	10.82	7	149659	12997	42458672
Transplant rejection	25.43	10.82	8	149658	13580	42458089
Torsade de pointes	25.31	10.82	77	149589	8517	42463152
Peritonitis bacterial	25.29	10.82	67	149599	6848	42464821
Breast mass	25.09	10.82	21	149645	735	42470934
Ejection fraction	24.87	10.82	13	149653	200	42471469
Therapeutic drug monitoring analysis incorrectly performed	24.78	10.82	15	149651	310	42471359
Angina pectoris	24.78	10.82	199	149467	32697	42438972
Basal cell carcinoma	24.67	10.82	26	149640	22707	42448962
Acute myeloid leukaemia	24.67	10.82	25	149641	22231	42449438
Gastric varices	24.64	10.82	20	149646	670	42470999
Faecal volume decreased	24.36	10.82	13	149653	209	42471460
Presyncope	24.27	10.82	148	149518	22239	42449430
Periarthritis calcarea	24.24	10.82	10	149656	86	42471583
Bundle branch block right	24.22	10.82	73	149593	8033	42463636
Aggression	24.19	10.82	77	149589	44086	42427583
Embolic stroke	23.94	10.82	54	149612	4986	42466683
Articular calcification	23.84	10.82	10	149656	90	42471579
Metabolic alkalosis	23.82	10.82	33	149633	2068	42469601
Hypoaesthesia	23.79	10.82	150	149516	71313	42400356
Aspergillus infection	23.72	10.82	13	149653	15824	42455845
Liver disorder	23.72	10.82	228	149438	39416	42432253
Atrial enlargement	23.68	10.82	20	149646	709	42470960
Poisoning	23.62	10.82	11	149655	14688	42456981
Circulatory collapse	23.59	10.82	153	149513	23483	42448186
Generalised tonic-clonic seizure	23.58	10.82	35	149631	26344	42445325
Weight increased	23.47	10.82	520	149146	107463	42364206
Creatinine renal clearance decreased	23.41	10.82	44	149622	3569	42468100
Blood cholesterol increased	23.40	10.82	36	149630	26705	42444964
Scrotal oedema	23.31	10.82	31	149635	1868	42469801
Sudden cardiac death	23.24	10.82	46	149620	3878	42467791
Pancytopenia	23.23	10.82	283	149383	117460	42354209
Localised oedema	23.18	10.82	47	149619	4031	42467638
Portal vein thrombosis	23.03	10.82	50	149616	4499	42467170
Oxygen saturation increased	23.02	10.82	14	149652	292	42471377
Oesophageal variceal ligation	23.01	10.82	10	149656	99	42471570
Platelet count normal	22.96	10.82	7	149659	21	42471648
Coma hepatic	22.85	10.82	16	149650	427	42471242
Therapy non-responder	22.76	10.82	103	149563	53256	42418413
Osteonecrosis of jaw	22.75	10.82	20	149646	19029	42452640
Blood aldosterone increased	22.71	10.82	7	149659	22	42471647
Blood sodium abnormal	22.59	10.82	18	149648	587	42471082
Tinnitus	22.52	10.82	42	149624	28896	42442773
Nephrolithiasis	22.50	10.82	61	149605	36769	42434900
Dyskinesia	22.39	10.82	34	149632	25356	42446313
Haematemesis	22.37	10.82	182	149484	30017	42441652
Blood ketone body increased	22.24	10.82	17	149649	521	42471148
Hypoalbuminaemia	22.14	10.82	111	149555	15499	42456170
Blood pressure systolic decreased	22.11	10.82	52	149614	4935	42466734
Disease progression	22.07	10.82	363	149303	143293	42328376
Rhabdoid tumour	22.04	10.82	7	149659	25	42471644
Xanthopsia	22.02	10.82	11	149655	153	42471516
Angina unstable	21.94	10.82	89	149577	11359	42460310
Prostate cancer	21.65	10.82	82	149584	44561	42427108
Acute myocardial infarction	21.58	10.82	305	149361	57860	42413809
Migraine	21.49	10.82	35	149631	25379	42446290
Psoriatic arthropathy	21.48	10.82	34	149632	24933	42446736
Fractured coccyx	21.29	10.82	11	149655	165	42471504
Diplopia	21.20	10.82	24	149642	20292	42451377
Epistaxis	21.14	10.82	341	149325	66485	42405184
Quadriparesis	20.99	10.82	33	149633	2317	42469352
Injection site erythema	20.92	10.82	24	149642	20171	42451498
Enteritis	20.91	10.82	6	149660	10810	42460859
Abdominal distension	20.84	10.82	361	149305	71374	42400295
Subdural haematoma	20.83	10.82	146	149520	22992	42448677
Immune reconstitution inflammatory syndrome	20.80	10.82	5	149661	10138	42461531
Spur cell anaemia	20.80	10.82	8	149658	56	42471613
Injection site reaction	20.67	10.82	15	149651	15706	42455963
Protein-losing gastroenteropathy	20.49	10.82	15	149651	430	42471239
Therapeutic response shortened	20.49	10.82	11	149655	13543	42458126
Ejection fraction abnormal	20.47	10.82	24	149642	1271	42470398
Exercise tolerance decreased	20.41	10.82	57	149609	6009	42465660
Diabetic hyperosmolar coma	20.39	10.82	16	149650	510	42471159
Miosis	20.20	10.82	11	149655	13435	42458234
Cytomegalovirus infection reactivation	20.19	10.82	7	149659	11171	42460498
Adrenal cyst	20.18	10.82	11	149655	185	42471484
Neoplasm progression	20.09	10.82	45	149621	28955	42442714
Injection site swelling	20.06	10.82	18	149648	16955	42454714
Electrocardiogram QRS complex abnormal	19.90	10.82	15	149651	450	42471219
Rales	19.80	10.82	86	149580	11314	42460355
Thrombocytopenia	19.68	10.82	513	149153	189766	42281903
Oral lichen planus	19.66	10.82	11	149655	195	42471474
Acute pulmonary oedema	19.66	10.82	71	149595	8580	42463089
Neck pain	19.65	10.82	48	149618	29966	42441703
Memory impairment	19.64	10.82	100	149566	50122	42421547
Haemophagocytic lymphohistiocytosis	19.60	10.82	21	149645	18201	42453468
Left atrial enlargement	19.47	10.82	21	149645	1014	42470655
Paracentesis	19.37	10.82	15	149651	469	42471200
Impaired quality of life	19.33	10.82	13	149653	14164	42457505
Rhinitis	19.19	10.82	9	149657	11968	42459701
Blood phosphorus increased	19.17	10.82	10	149656	12515	42459154
Left ventricular hypertrophy	19.11	10.82	74	149592	9245	42462424
Alopecia	19.03	10.82	47	149619	29229	42442440
Back pain	19.00	10.82	367	149299	141409	42330260
Rhabdomyolysis	18.99	10.82	382	149284	77637	42394032
Psychotic disorder	18.90	10.82	47	149619	29161	42442508
Sinus arrest	18.88	10.82	30	149636	2126	42469543
Invasive ductal breast carcinoma	18.79	10.82	8	149658	75	42471594
Haematoma	18.70	10.82	165	149501	27858	42443811
Hydrocholecystis	18.70	10.82	15	149651	494	42471175
Eosinophilia	18.61	10.82	187	149479	32712	42438957
Neurological symptom	18.49	10.82	6	149660	9985	42461684
International normalised ratio decreased	18.48	10.82	46	149620	4526	42467143
Abdominal discomfort	18.43	10.82	172	149494	75083	42396586
Product storage error	18.42	10.82	8	149658	11132	42460537
International normalised ratio fluctuation	18.42	10.82	23	149643	1301	42470368
Chills	18.20	10.82	227	149439	93839	42377830
Erysipelas	18.16	10.82	56	149610	6240	42465429
Uveitis	18.15	10.82	5	149661	9253	42462416
Hydrothorax	18.11	10.82	16	149650	603	42471066
Haematotoxicity	17.99	10.82	8	149658	10977	42460692
Myasthenic syndrome	17.85	10.82	18	149648	803	42470866
Product prescribing error	17.56	10.82	154	149512	25958	42445711
Prerenal failure	17.50	10.82	31	149635	2402	42469267
Micturition urgency	17.49	10.82	10	149656	11888	42459781
Ventricular extrasystoles	17.46	10.82	93	149573	13297	42458372
Nephrogenic anaemia	17.39	10.82	32	149634	2554	42469115
Sinus bradycardia	17.26	10.82	100	149566	14753	42456916
Asthma	17.22	10.82	138	149528	62176	42409493
Vision blurred	17.21	10.82	114	149552	53585	42418084
Poisoning deliberate	17.21	10.82	7	149659	10127	42461542
Bacterial infection	17.16	10.82	46	149620	27833	42443836
Thrombotic microangiopathy	17.08	10.82	16	149650	14766	42456903
Stomatitis	17.08	10.82	105	149561	50224	42421445
Agitation	17.06	10.82	144	149522	64170	42407499
Hypochromic anaemia	17.05	10.82	20	149646	1060	42470609
Inferior vena cava syndrome	16.99	10.82	7	149659	60	42471609
Pericardial calcification	16.97	10.82	6	149660	32	42471637
Immune effector cell-associated neurotoxicity syndrome	16.96	10.82	6	149660	9455	42462214
Inappropriate schedule of product administration	16.89	10.82	236	149430	95666	42376003
Labelled drug-drug interaction medication error	16.88	10.82	103	149563	15479	42456190
Swelling	16.86	10.82	118	149548	54767	42416902
Agranulocytosis	16.83	10.82	173	149493	30439	42441230
Asthenia	16.82	10.82	1173	148493	279620	42192049
Base excess decreased	16.81	10.82	10	149656	200	42471469
Immature granulocyte count increased	16.80	10.82	11	149655	262	42471407
Blood chloride increased	16.78	10.82	38	149628	3518	42468151
Fluid intake reduced	16.75	10.82	41	149625	3991	42467678
Cardioversion	16.58	10.82	19	149647	982	42470687
Left atrial dilatation	16.50	10.82	30	149636	2372	42469297
Bladder irrigation	16.50	10.82	7	149659	65	42471604
Feeling abnormal	16.45	10.82	161	149505	69625	42402044
Endometriosis male	16.40	10.82	5	149661	15	42471654
Nightmare	16.38	10.82	40	149626	24972	42446697
Azotaemia	16.34	10.82	52	149614	5892	42465777
Cystitis haemorrhagic	16.29	10.82	3	149663	7326	42464343
Infection	16.29	10.82	286	149380	111782	42359887
Transplant evaluation	16.27	10.82	14	149652	509	42471160
Testicular swelling	16.20	10.82	27	149639	1992	42469677
Peptic ulcer perforation	16.18	10.82	12	149654	351	42471318
Irritability	16.14	10.82	48	149618	28080	42443589
Apparent mineralocorticoid excess	16.14	10.82	7	149659	69	42471600
Haematuria	16.12	10.82	289	149377	57510	42414159
Dermatomyositis	15.98	10.82	24	149642	1619	42470050
Sleep disorder	15.98	10.82	101	149565	47994	42423675
Oesophageal carcinoma	15.98	10.82	7	149659	9689	42461980
Infected dermal cyst	15.94	10.82	18	149648	915	42470754
Pulmonary veno-occlusive disease	15.92	10.82	15	149651	615	42471054
Pancreatitis	15.89	10.82	88	149578	43180	42428489
Colitis	15.89	10.82	97	149569	46475	42425194
Transferrin saturation decreased	15.89	10.82	14	149652	526	42471143
Bladder cancer	15.84	10.82	22	149644	17025	42454644
Dry mouth	15.83	10.82	79	149587	39800	42431869
Atrioventricular block second degree	15.75	10.82	41	149625	4146	42467523
Influenza	15.70	10.82	141	149525	62034	42409635
Atrial flutter	15.62	10.82	109	149557	17142	42454527
Conduction disorder	15.49	10.82	30	149636	2488	42469181
Asthma-chronic obstructive pulmonary disease overlap syndrome	15.49	10.82	23	149643	1536	42470133
Hyperaldosteronism	15.47	10.82	10	149656	233	42471436
Hepatomegaly	15.46	10.82	82	149584	11703	42459966
Ankylosing spondylitis	15.45	10.82	3	149663	7053	42464616
Atrioventricular block first degree	15.37	10.82	54	149612	6437	42465232
Dyspnoea at rest	15.37	10.82	41	149625	4208	42467461
Tachycardia	15.33	10.82	256	149410	100831	42370838
Oropharyngeal pain	15.32	10.82	87	149579	42423	42429246
Diffuse large B-cell lymphoma	15.30	10.82	7	149659	9447	42462222
Impaired work ability	15.30	10.82	12	149654	12079	42459590
Forced expiratory volume decreased	15.19	10.82	4	149662	7626	42464043
Pneumocystis jirovecii pneumonia	15.16	10.82	42	149624	25139	42446530
Stasis dermatitis	15.13	10.82	20	149646	1198	42470471
Hepatic pain	15.04	10.82	23	149643	1577	42470092
Hallucination, auditory	15.04	10.82	18	149648	14846	42456823
BK virus infection	15.02	10.82	6	149660	8778	42462891
Tooth disorder	15.02	10.82	12	149654	11967	42459702
Frequent bowel movements	15.01	10.82	33	149633	21374	42450295
Electrocardiogram change	14.99	10.82	15	149651	663	42471006
Blood thyroid stimulating hormone abnormal	14.99	10.82	12	149654	394	42471275
Activated partial thromboplastin time shortened	14.96	10.82	13	149653	479	42471190
Herpes zoster	14.87	10.82	78	149588	38799	42432870
Diffuse vasculitis	14.85	10.82	7	149659	85	42471584
Porphyria acute	14.73	10.82	12	149654	404	42471265
Intracranial aneurysm	14.66	10.82	24	149642	1744	42469925
Blood potassium decreased	14.64	10.82	122	149544	20262	42451407
Loss of consciousness	14.53	10.82	426	149240	91928	42379741
Drug withdrawal syndrome	14.48	10.82	34	149632	21515	42450154
Nocturnal dyspnoea	14.46	10.82	14	149652	594	42471075
International normalised ratio abnormal	14.43	10.82	35	149631	3388	42468281
Myocardial fibrosis	14.41	10.82	20	149646	1255	42470414
Concomitant disease progression	14.41	10.82	29	149637	2474	42469195
Syringe issue	14.38	10.82	6	149660	8550	42463119
Transfusion	14.38	10.82	74	149592	10440	42461229
Drug hypersensitivity	14.33	10.82	254	149412	99135	42372534
Left ventricular false tendon	14.31	10.82	6	149660	54	42471615
Blood creatinine abnormal	14.28	10.82	33	149633	3096	42468573
Plasma cell myeloma	14.27	10.82	103	149563	47475	42424194
Encephalopathy	14.25	10.82	214	149452	41119	42430550
Serotonin syndrome	14.20	10.82	45	149621	25800	42445869
Prothrombin level increased	14.18	10.82	9	149657	203	42471466
Acute respiratory distress syndrome	14.15	10.82	56	149610	30052	42441617
Parkinsonism	14.14	10.82	10	149656	10613	42461056
Tuberculosis	14.12	10.82	9	149657	10090	42461579
Hypopnoea	14.12	10.82	5	149661	7877	42463792
Tricuspid valve replacement	14.09	10.82	5	149661	27	42471642
Hyperuricaemia	14.07	10.82	68	149598	9356	42462313
Cardiac output decreased	14.03	10.82	18	149648	1047	42470622
Electrolyte depletion	14.02	10.82	10	149656	275	42471394
Prothrombin level decreased	14.00	10.82	19	149647	1167	42470502
Nodule	13.98	10.82	14	149652	12520	42459149
Preternatural anus	13.97	10.82	7	149659	98	42471571
Secondary sexual characteristics absence	13.97	10.82	3	149663	0	42471669
Cytopenia	13.97	10.82	25	149641	17472	42454197
Lipoprotein (a) increased	13.96	10.82	11	149655	353	42471316
Schizophrenia	13.95	10.82	10	149656	10540	42461129
Child-Pugh-Turcotte score increased	13.94	10.82	5	149661	28	42471641
Eye pain	13.89	10.82	24	149642	17006	42454663
Systolic dysfunction	13.89	10.82	32	149634	2996	42468673
Hypoglycaemia	13.88	10.82	291	149375	59563	42412106
Influenza like illness	13.86	10.82	61	149605	31779	42439890
Neurotoxicity	13.83	10.82	40	149626	23611	42448058
Ataxia	13.83	10.82	22	149644	16103	42455566
End stage renal disease	13.82	10.82	23	149643	16535	42455134
Drug level decreased	13.81	10.82	9	149657	9968	42461701
Atrial pressure increased	13.79	10.82	5	149661	29	42471640
Blood test abnormal	13.74	10.82	15	149651	12891	42458778
Cataract	13.70	10.82	58	149608	30546	42441123
Burning feet syndrome	13.67	10.82	7	149659	103	42471566
Rash erythematous	13.65	10.82	62	149604	32029	42439640
Percussion test abnormal	13.65	10.82	5	149661	30	42471639
Subcutaneous haematoma	13.63	10.82	18	149648	1077	42470592
Blood alkaline phosphatase increased	13.61	10.82	179	149487	33418	42438251
Hypogammaglobulinaemia	13.59	10.82	13	149653	11878	42459791
Lung diffusion test abnormal	13.58	10.82	6	149660	62	42471607
Ulcer	13.57	10.82	23	149643	16418	42455251
Crepitations	13.52	10.82	34	149632	3367	42468302
Blood lactic acid decreased	13.50	10.82	6	149660	63	42471606
Ear infection	13.50	10.82	15	149651	12789	42458880
Dysgeusia	13.41	10.82	68	149598	34121	42437548
Dependence on oxygen therapy	13.36	10.82	9	149657	225	42471444
Fungal infection	13.34	10.82	31	149635	19691	42451978
Hypophosphataemia	13.32	10.82	34	149632	20911	42450758
Bronchiectasis	13.28	10.82	27	149639	17992	42453677
Red cell distribution width increased	13.24	10.82	54	149612	6910	42464759
Blood creatine increased	13.14	10.82	47	149619	5653	42466016
Paranoia	13.14	10.82	18	149648	14008	42457661
Bronchial hyperreactivity	13.14	10.82	24	149642	1905	42469764
Rectosigmoid cancer metastatic	13.12	10.82	4	149662	12	42471657
Heart transplant	13.10	10.82	17	149649	1000	42470669
Night sweats	13.02	10.82	32	149634	19937	42451732
Hepatotoxicity	13.01	10.82	45	149621	25122	42446547
Pneumonia	12.91	10.82	1292	148374	420857	42050812
Right ventricular dysfunction	12.89	10.82	20	149646	1389	42470280
Disease recurrence	12.83	10.82	57	149609	29621	42442048
Exposure during pregnancy	12.83	10.82	7	149659	8541	42463128
Withdrawal syndrome	12.82	10.82	20	149646	14755	42456914
Haemodynamic test abnormal	12.77	10.82	5	149661	37	42471632
Lymph nodes scan abnormal	12.77	10.82	5	149661	37	42471632
Dilatation ventricular	12.76	10.82	28	149638	2538	42469131
Blood pressure abnormal	12.73	10.82	69	149597	9929	42461740
Urine protein/creatinine ratio increased	12.68	10.82	15	149651	802	42470867
Hormone receptor positive breast cancer	12.65	10.82	5	149661	38	42471631
Scrotal swelling	12.61	10.82	21	149645	1548	42470121
Cerebral infarction	12.60	10.82	166	149500	31003	42440666
Fistula	12.59	10.82	6	149660	7906	42463763
Infected skin ulcer	12.53	10.82	24	149642	1974	42469695
Left ventricular enlargement	12.46	10.82	15	149651	817	42470852
Prescribed underdose	12.45	10.82	70	149596	10212	42461457
Lower respiratory tract infection	12.45	10.82	89	149577	41117	42430552
Mycobacterium ulcerans infection	12.44	10.82	6	149660	77	42471592
Brain oedema	12.44	10.82	24	149642	16303	42455366
NYHA classification	12.43	10.82	5	149661	40	42471629
Gastric ulcer	12.43	10.82	108	149558	18154	42453515
Hypophagia	12.37	10.82	147	149519	26809	42444860
Substance abuse	12.37	10.82	8	149658	8897	42462772
Cardiac hypertrophy	12.34	10.82	18	149648	1183	42470486
Infective pulmonary exacerbation of cystic fibrosis	12.33	10.82	6	149660	7812	42463857
Chronic graft versus host disease	12.30	10.82	3	149663	6022	42465647
Hepatic calcification	12.29	10.82	10	149656	336	42471333
Drug effective for unapproved indication	12.25	10.82	4	149662	6629	42465040
Pulmonary vein stenosis	12.22	10.82	5	149661	42	42471627
Ventricular arrhythmia	12.18	10.82	49	149617	6230	42465439
Dyspepsia	12.17	10.82	90	149576	41262	42430407
Shock haemorrhagic	12.09	10.82	98	149568	16144	42455525
Hypoparathyroidism secondary	12.02	10.82	8	149658	196	42471473
Device inappropriate shock delivery	12.02	10.82	5	149661	44	42471625
Venous oxygen saturation decreased	12.02	10.82	5	149661	44	42471625
Ventricular fibrillation	12.00	10.82	160	149506	29963	42441706
Deep vein thrombosis	11.96	10.82	194	149472	76763	42394906
Pacemaker generated arrhythmia	11.90	10.82	3	149663	3	42471666
Pulmonary hypertensive crisis	11.88	10.82	8	149658	200	42471469
Perineal infection	11.87	10.82	13	149653	639	42471030
Neuralgia	11.86	10.82	48	149618	25599	42446070
Erythema	11.85	10.82	291	149375	108502	42363167
Epstein-Barr virus infection	11.85	10.82	10	149656	9708	42461961
Aortic valve incompetence	11.84	10.82	50	149616	6498	42465171
Sinus arrhythmia	11.83	10.82	15	149651	862	42470807
Extrapyramidal disorder	11.76	10.82	25	149641	16387	42455282
Hypertension	11.72	10.82	474	149192	166730	42304939
Portal shunt procedure	11.69	10.82	4	149662	19	42471650
Contraindicated product administered	11.68	10.82	138	149528	25134	42446535
Hypertriglyceridaemia	11.65	10.82	11	149655	10115	42461554
Cardiorenal syndrome	11.61	10.82	15	149651	878	42470791
Restless legs syndrome	11.60	10.82	10	149656	9604	42462065
Vasculitis	11.59	10.82	30	149636	18364	42453305
Hot flush	11.53	10.82	40	149626	22311	42449358
Apheresis related complication	11.52	10.82	4	149662	20	42471649
Hypoglycaemic coma	11.51	10.82	28	149638	2716	42468953
Goitre	11.50	10.82	22	149644	1808	42469861
Coordination abnormal	11.50	10.82	7	149659	8043	42463626
Intracardiac thrombus	11.49	10.82	26	149640	2406	42469263
Wrong technique in product usage process	11.47	10.82	212	149454	42423	42429246
Toxic epidermal necrolysis	11.46	10.82	144	149522	26606	42445063
Dizziness postural	11.46	10.82	56	149610	7739	42463930
Pathogen resistance	11.44	10.82	14	149652	11436	42460233
Large intestine perforation	11.40	10.82	10	149656	9526	42462143
Product quality issue	11.39	10.82	29	149637	17853	42453816
Coronary artery bypass	11.38	10.82	40	149626	4770	42466899
Urine osmolarity decreased	11.38	10.82	5	149661	51	42471618
Ectopic ACTH syndrome	11.36	10.82	4	149662	21	42471648
Joint stiffness	11.35	10.82	16	149650	12306	42459363
Middle insomnia	11.32	10.82	56	149610	7777	42463892
Abnormal behaviour	11.31	10.82	51	149615	26400	42445269
Defect conduction intraventricular	11.30	10.82	11	149655	470	42471199
Postrenal failure	11.27	10.82	12	149654	571	42471098
Muscle haemorrhage	11.26	10.82	36	149630	4089	42467580
Squamous cell carcinoma of skin	11.26	10.82	17	149649	12709	42458960
Cardiac asthma	11.22	10.82	8	149658	220	42471449
Body mass index decreased	11.18	10.82	9	149657	298	42471371
Eye irritation	11.14	10.82	14	149652	11304	42460365
Muscle spasticity	11.12	10.82	5	149661	6817	42464852
Exostosis	11.12	10.82	3	149663	5628	42466041
Intervertebral disc degeneration	11.10	10.82	6	149660	7361	42464308
Glomerular filtration rate increased	11.10	10.82	14	149652	800	42470869
Optic nerve operation	11.09	10.82	11	149655	481	42471188
Pulmonary fibrosis	11.08	10.82	52	149614	26629	42445040
Oxygen consumption decreased	11.08	10.82	9	149657	302	42471367
Splinter haemorrhages	11.05	10.82	6	149660	100	42471569
Hyperbilirubinaemia	11.05	10.82	116	149550	20519	42451150
Haemoglobin decreased	11.05	10.82	570	149096	131901	42339768
Acute abdomen	11.02	10.82	23	149643	2014	42469655
Post procedural haemorrhage	11.02	10.82	63	149603	9249	42462420
Restlessness	11.01	10.82	59	149607	29190	42442479
Electrocardiogram T wave amplitude increased	11	10.82	6	149660	101	42471568
Upper respiratory tract inflammation	10.95	10.82	22	149644	1874	42469795
Rash pruritic	10.94	10.82	71	149595	33532	42438137
CSF protein abnormal	10.92	10.82	4	149662	24	42471645
Therapeutic embolisation	10.90	10.82	9	149657	309	42471360
Endocarditis	10.89	10.82	57	149609	8095	42463574
Systemic lupus erythematosus	10.88	10.82	10	149656	9314	42462355
Nervous system disorder	10.87	10.82	28	149638	17167	42454502

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperkalaemia	6102.69	10.10	4126	306502	131670	110147001
Acute kidney injury	3383.68	10.10	6237	304391	629193	109649478
Cardiac failure	2016.70	10.10	2558	308070	185068	110093603
Hyponatraemia	1325.04	10.10	2271	308357	215382	110063289
Hepatic encephalopathy	1084.91	10.10	781	309847	27475	110251196
Hypotension	1032.02	10.10	3524	307104	520325	109758346
Cardiac failure congestive	779.32	10.10	1467	309161	149533	110129138
Ascites	773.13	10.10	1119	309509	91689	110186982
Renal impairment	764.17	10.10	1656	308972	186789	110091882
Pulmonary arterial hypertension	720.48	10.10	652	309976	31916	110246755
Dehydration	709.10	10.10	2054	308574	277457	110001214
Drug interaction	705.66	10.10	3027	307601	497156	109781515
Synovitis	700.70	10.10	14	310614	274078	110004593
Right ventricular failure	657.07	10.10	561	310067	25393	110253278
Dyspnoea	626.12	10.10	5267	305361	1101605	109177066
Pulmonary hypertension	621.08	10.10	771	309857	54449	110224222
Cardiac failure chronic	602.85	10.10	413	310215	13398	110265273
Drug ineffective	598.61	10.10	2230	308398	1518310	108760361
Hand deformity	580.58	10.10	6	310622	218500	110060171
Renal failure	579.24	10.10	1670	308958	224904	110053767
Arthropathy	572.22	10.10	68	310560	287454	109991217
Infusion related reaction	546.49	10.10	194	310434	380968	109897703
Oedema peripheral	542.32	10.10	2089	308539	326571	109952100
Bradycardia	540.56	10.10	1286	309342	154231	110124440
Pemphigus	518.56	10.10	19	310609	214551	110064120
Joint swelling	496.27	10.10	316	310312	442529	109836142
Glossodynia	491.23	10.10	34	310594	221970	110056701
Atrial fibrillation	490.06	10.10	1589	309039	228053	110050618
Systemic lupus erythematosus	487.14	10.10	68	310560	254270	110024401
Blood creatinine increased	484.81	10.10	1366	309262	181523	110097148
Duodenal ulcer perforation	439.09	10.10	13	310615	177687	110100984
Helicobacter infection	429.71	10.10	19	310609	181858	110096813
Therapeutic product effect decreased	420.14	10.10	87	310541	244229	110034442
Maternal exposure during pregnancy	417.73	10.10	101	310527	254782	110023889
Folliculitis	411.58	10.10	13	310615	167640	110111031
International normalised ratio increased	403.44	10.10	807	309821	85965	110192706
Blood potassium increased	402.67	10.10	482	310146	32767	110245904
Drug intolerance	400.78	10.10	332	310296	406180	109872491
Treatment failure	397.41	10.10	141	310487	277093	110001578
Rheumatoid arthritis	389.32	10.10	177	310451	299436	109979235
Pericarditis	383.06	10.10	75	310553	219039	110059632
Muscle injury	368.90	10.10	5	310623	140802	110137869
Psoriatic arthropathy	366.58	10.10	57	310571	196704	110081967
Hepatic failure	363.30	10.10	675	309953	68064	110210607
Hypersensitivity	351.06	10.10	370	310258	403628	109875043
Wound	345.05	10.10	114	310514	234323	110044348
Musculoskeletal stiffness	342.73	10.10	179	310449	279643	109999028
Blood urea increased	331.86	10.10	572	310056	54385	110224286
Hepatic enzyme increased	328.86	10.10	252	310376	320640	109958031
Syncope	326.88	10.10	1279	309349	201257	110077414
Gynaecomastia	325.20	10.10	245	310383	9245	110269426
Off label use	323.43	10.10	2683	307945	1497502	108781169
Impaired healing	322.20	10.10	78	310550	196639	110082032
Irritable bowel syndrome	321.30	10.10	41	310587	164174	110114497
Alopecia	320.32	10.10	331	310297	364422	109914249
Pain	311.01	10.10	1503	309125	953452	109325219
C-reactive protein abnormal	298.48	10.10	16	310612	129679	110148992
N-terminal prohormone brain natriuretic peptide increased	295.80	10.10	195	310433	5926	110272745
Ventricular tachycardia	290.88	10.10	512	310116	49497	110229174
Fluid retention	288.57	10.10	743	309885	93564	110185107
Drug abuse	281.58	10.10	75	310553	177336	110101335
Bursitis	281.32	10.10	22	310606	129896	110148775
Arthralgia	280.65	10.10	1182	309446	778450	109500221
Hypervolaemia	279.47	10.10	500	310128	48960	110229711
Dyspnoea exertional	279.27	10.10	781	309847	103279	110175392
Lower respiratory tract infection	276.89	10.10	170	310458	242936	110035735
BRASH syndrome	276.09	10.10	156	310472	3567	110275104
Cardiac failure acute	275.19	10.10	339	310289	23739	110254932
Hypokalaemia	270.30	10.10	1122	309506	181326	110097345
Anaemia	269.22	10.10	2529	308099	544557	109734114
Joint range of motion decreased	268.45	10.10	19	310609	121813	110156858
Blood cholesterol increased	266.42	10.10	93	310535	184692	110093979
Stomatitis	262.15	10.10	224	310404	270018	110008653
Orthopnoea	254.30	10.10	226	310402	10795	110267876
Abdominal discomfort	249.50	10.10	453	310175	393405	109885266
Chronic kidney disease	249.00	10.10	616	310012	75675	110202996
Ill-defined disorder	245.74	10.10	68	310560	156785	110121886
Gastrointestinal haemorrhage	242.91	10.10	1015	309613	164503	110114168
Discomfort	240.55	10.10	153	310475	214554	110064117
Melaena	239.18	10.10	569	310059	68188	110210483
Lip dry	237.87	10.10	10	310618	100073	110178598
Completed suicide	234.97	10.10	201	310427	242180	110036491
Drug hypersensitivity	229.83	10.10	592	310036	453498	109825173
Exposure during pregnancy	226.77	10.10	93	310535	167331	110111340
Sinusitis	226.29	10.10	301	310327	296387	109982284
Contraindicated product administered	221.61	10.10	222	310406	248045	110030626
Hepatocellular carcinoma	218.86	10.10	198	310430	9682	110268989
Fall	217.77	10.10	2621	308007	600861	109677810
Urticaria	217.25	10.10	350	310278	318507	109960164
Brain natriuretic peptide increased	216.25	10.10	208	310420	11001	110267670
Mobility decreased	215.72	10.10	209	310419	237213	110041458
Congestive cardiomyopathy	214.42	10.10	231	310397	13988	110264683
Ejection fraction decreased	212.93	10.10	399	310229	40481	110238190
Rash	212.69	10.10	1392	309236	819572	109459099
Oesophageal varices haemorrhage	209.03	10.10	145	310483	4800	110273871
Febrile neutropenia	205.37	10.10	359	310269	316408	109962263
Product use in unapproved indication	203.55	10.10	614	310014	446763	109831908
Swelling	203.01	10.10	426	310202	350615	109928056
Orthostatic hypotension	201.66	10.10	521	310107	65728	110212943
Blood pressure decreased	201.39	10.10	746	309882	114345	110164326
Atrioventricular block complete	199.92	10.10	264	310364	19818	110258853
Hepatorenal syndrome	199.50	10.10	137	310491	4460	110274211
Hepatic cirrhosis	197.85	10.10	524	310104	67102	110211569
Glomerular filtration rate decreased	197.02	10.10	318	310310	28638	110250033
Nasopharyngitis	195.79	10.10	519	310109	393842	109884829
Intentional product use issue	194.70	10.10	246	310382	247660	110031011
Osteoarthritis	192.69	10.10	139	310489	182484	110096187
Grip strength decreased	190.57	10.10	8	310620	80166	110198505
Cardiac disorder	187.69	10.10	555	310073	75725	110202946
Gastrointestinal disorder	187.00	10.10	243	310385	241709	110036962
Mitral valve incompetence	185.81	10.10	335	310293	32994	110245677
Sleep disorder due to general medical condition, insomnia type	184.91	10.10	36	310592	105607	110173064
Injury	183.04	10.10	138	310490	177127	110101544
Night sweats	178.90	10.10	76	310552	133907	110144764
Blister	175.06	10.10	229	310399	227147	110051524
Hypoaesthesia	172.84	10.10	392	310236	313831	109964840
Atrioventricular block	171.31	10.10	224	310404	16653	110262018
Arrhythmia	170.02	10.10	505	310123	69070	110209601
Sleep disorder	168.96	10.10	185	310443	198459	110080212
Liver injury	165.97	10.10	109	310519	150304	110128367
Live birth	164.93	10.10	7	310621	69477	110209194
Polycystic ovaries	164.74	10.10	124	310504	4672	110273999
Sensitisation	162.18	10.10	116	310512	4035	110274636
Blood bilirubin increased	162.09	10.10	526	310102	75446	110203225
Varices oesophageal	158.66	10.10	144	310484	7071	110271600
Ejection fraction	157.20	10.10	100	310528	2855	110275816
Product prescribing error	156.55	10.10	404	310224	50927	110227744
Wound infection	152.62	10.10	41	310587	96424	110182247
Lactic acidosis	151.95	10.10	589	310039	92222	110186449
Fibromyalgia	151.14	10.10	154	310474	170755	110107916
Dry mouth	150.22	10.10	205	310423	199743	110078928
Cardiomegaly	150.06	10.10	283	310345	28847	110249824
Tricuspid valve incompetence	148.74	10.10	252	310376	23621	110255050
Ischaemic cardiomyopathy	147.68	10.10	145	310483	7866	110270805
Paraesthesia	146.41	10.10	352	310276	276169	110002502
Cardioactive drug level increased	146.00	10.10	106	310522	3776	110274895
Toxicity to various agents	142.01	10.10	781	309847	479774	109798897
Hypovolaemia	141.99	10.10	234	310394	21440	110257231
Arthritis	141.49	10.10	157	310471	167429	110111242
Electrolyte imbalance	140.36	10.10	317	310311	36711	110241960
Hypercholesterolaemia	137.45	10.10	42	310586	90795	110187876
Product use issue	135.16	10.10	437	310191	311258	109967413
Inflammation	132.59	10.10	211	310417	193027	110085644
Pulmonary oedema	131.35	10.10	596	310032	100063	110178608
Pleural effusion	129.94	10.10	900	309728	176809	110101862
Renal disorder	129.41	10.10	368	310260	49111	110229560
Therapeutic product effect incomplete	128.97	10.10	272	310356	223533	110055138
Blepharospasm	128.63	10.10	6	310622	54845	110223826
Product monitoring error	127.59	10.10	141	310487	8786	110269885
Type 2 diabetes mellitus	125.93	10.10	189	310439	177043	110101628
Peripheral venous disease	125.29	10.10	40	310588	84077	110194594
Cardiogenic shock	125.04	10.10	400	310228	56938	110221733
Blood sodium decreased	123.52	10.10	308	310320	38011	110240660
Gait inability	121.58	10.10	122	310506	136254	110142417
Concomitant disease aggravated	120.00	10.10	186	310442	16178	110262493
Ejection fraction abnormal	117.83	10.10	89	310539	3371	110275300
Bundle branch block left	116.99	10.10	162	310466	12726	110265945
Hepatic cancer	114.68	10.10	149	310479	11007	110267664
Intentional overdose	114.20	10.10	122	310506	132379	110146292
Cardiomyopathy	113.94	10.10	275	310353	33250	110245421
Bone erosion	112.34	10.10	4	310624	46367	110232304
Infection	111.75	10.10	580	310048	361620	109917051
Lower limb fracture	110.16	10.10	37	310591	75311	110203360
Sciatica	108.83	10.10	62	310566	92337	110186334
Myelosuppression	108.71	10.10	65	310563	94275	110184396
Obesity	108.57	10.10	95	310533	113256	110165415
Red blood cell sedimentation rate increased	106.81	10.10	43	310585	78259	110200412
Metabolic acidosis	106.74	10.10	558	310070	99186	110179485
Neutropenia	106.73	10.10	616	310012	374004	109904667
Hepatic function abnormal	105.73	10.10	514	310114	88781	110189890
Labelled drug-drug interaction medication error	105.69	10.10	246	310382	29056	110249615
Nail disorder	102.96	10.10	19	310609	57916	110220755
Ammonia increased	102.18	10.10	121	310507	8129	110270542
Epistaxis	100.50	10.10	669	309959	129703	110148968
Atrial flutter	100.21	10.10	215	310413	24047	110254624
Haematemesis	99.92	10.10	379	310249	58729	110219942
Pulmonary congestion	99.92	10.10	249	310379	30717	110247954
Haematoma	99.73	10.10	376	310252	58100	110220571
Pyrexia	99.46	10.10	1851	308777	896414	109382257
Injection site reaction	98.99	10.10	64	310564	89006	110189665
Onychomadesis	98.09	10.10	8	310620	45655	110233016
Jaundice	97.82	10.10	377	310251	58859	110219812
Upper gastrointestinal haemorrhage	96.36	10.10	335	310293	49761	110228910
Generalised oedema	95.01	10.10	243	310385	30461	110248210
Autoimmune disorder	94.27	10.10	33	310595	65450	110213221
Congestive hepatopathy	93.47	10.10	93	310535	5127	110273544
Transfusion	93.14	10.10	215	310413	25257	110253414
Colitis ulcerative	90.98	10.10	52	310576	77311	110201360
Electrocardiogram abnormal	90.52	10.10	177	310451	18532	110260139
Migraine	90.43	10.10	219	310409	171433	110107238
Pain in jaw	89.71	10.10	332	310296	50845	110227826
Therapeutic drug monitoring analysis not performed	89.64	10.10	60	310568	1871	110276800
Prescribed overdose	89.34	10.10	69	310559	87512	110191159
Left ventricular failure	88.52	10.10	133	310495	11256	110267415
Polyuria	88.49	10.10	170	310458	17568	110261103
Prothrombin time prolonged	88.05	10.10	167	310461	17094	110261577
Knee arthroplasty	88.04	10.10	36	310592	64912	110213759
Hip arthroplasty	87.76	10.10	24	310604	55789	110222882
Rhabdomyolysis	87.53	10.10	609	310019	119792	110158879
Road traffic accident	86.98	10.10	104	310524	107294	110171377
X-ray abnormal	86.76	10.10	5	310623	38112	110240559
Wheezing	84.85	10.10	398	310230	254832	110023839
Adverse drug reaction	83.60	10.10	104	310524	105455	110173216
Pulmonary fibrosis	83.51	10.10	98	310530	101944	110176727
Anuria	83.07	10.10	200	310428	24141	110254530
Product quality issue	79.99	10.10	60	310568	77239	110201432
Anxiety	78.87	10.10	606	310022	344472	109934199
Haemoglobin decreased	78.68	10.10	1055	309573	247672	110030999
Pemphigoid	78.38	10.10	172	310456	19535	110259136
Portal hypertension	77.55	10.10	108	310520	8529	110270142
Injection site pain	77.39	10.10	249	310379	177673	110100998
Inability to afford medication	75.55	10.10	74	310554	4002	110274669
Oedema	75.47	10.10	912	309716	209064	110069607
Epilepsy	74.98	10.10	103	310525	100106	110178565
Coeliac disease	74.97	10.10	15	310613	43172	110235499
Left ventricular dysfunction	73.80	10.10	187	310441	23306	110255365
Oliguria	73.26	10.10	162	310466	18495	110260176
Cardiac arrest	73.10	10.10	860	309768	195893	110082778
Pregnancy	73.06	10.10	26	310602	51041	110227630
Sinus node dysfunction	72.25	10.10	107	310521	8940	110269731
Subdural haematoma	72.05	10.10	246	310382	36208	110242463
Urine output decreased	71.83	10.10	167	310461	19709	110258962
Sleep apnoea syndrome	71.40	10.10	263	310365	40184	110238487
Systemic infection	71.15	10.10	111	310517	9708	110268963
C-reactive protein increased	70.56	10.10	343	310285	217576	110061095
Pericardial effusion	70.36	10.10	333	310295	56884	110221787
Exostosis	69.97	10.10	21	310607	45935	110232736
Depression	69.85	10.10	563	310065	316772	109961899
Sudden death	69.28	10.10	187	310441	24208	110254463
Metabolic alkalosis	69.19	10.10	82	310546	5513	110273158
Renin increased	68.88	10.10	29	310599	337	110278334
Musculoskeletal pain	68.39	10.10	273	310355	182750	110095921
Dyspepsia	68.14	10.10	290	310338	190675	110087996
Vital capacity decreased	67.68	10.10	52	310576	2021	110276650
Cardiac amyloidosis	67.09	10.10	59	310569	2778	110275893
General physical health deterioration	66.85	10.10	1615	309013	423680	109854991
Ischaemic stroke	66.81	10.10	261	310367	41002	110237669
Pulmonary arterial pressure increased	66.50	10.10	77	310551	5050	110273621
Paracentesis	66.19	10.10	44	310584	1356	110277315
Onychomycosis	65.61	10.10	14	310614	38517	110240154
Muscle spasticity	65.52	10.10	11	310617	35904	110242767
Low cardiac output syndrome	65.32	10.10	40	310588	1066	110277605
Blood potassium decreased	65.13	10.10	313	310315	53801	110224870
Intentional product misuse	65.03	10.10	176	310452	132728	110145943
Back injury	64.69	10.10	26	310602	47373	110231298
Brain natriuretic peptide abnormal	64.52	10.10	37	310591	871	110277800
Sputum culture positive	63.65	10.10	66	310562	3823	110274848
Joint stiffness	63.62	10.10	57	310571	67186	110211485
Iron deficiency anaemia	63.28	10.10	214	310414	31345	110247326
Inappropriate antidiuretic hormone secretion	63.06	10.10	224	310404	33627	110245044
Pulmonary arterial pressure abnormal	62.85	10.10	37	310591	916	110277755
Dizziness	62.78	10.10	2476	308152	695717	109582954
Hypoglycaemia	62.10	10.10	547	310081	115557	110163114
Chronic obstructive pulmonary disease	61.38	10.10	520	310108	108638	110170033
Prerenal failure	61.27	10.10	69	310559	4390	110274281
Taste disorder	61.17	10.10	56	310572	65331	110213340
Bundle branch block right	60.34	10.10	117	310511	12174	110266497
Shock haemorrhagic	60.23	10.10	191	310437	27056	110251615
Anaphylactic reaction	60.05	10.10	146	310482	114154	110164517
Incorrect route of product administration	59.77	10.10	55	310573	64006	110214665
Liver transplant	59.65	10.10	69	310559	4520	110274151
Foot deformity	59.31	10.10	31	310597	48449	110230222
Glomerular filtration rate abnormal	59.26	10.10	51	310577	2332	110276339
Therapy non-responder	59.18	10.10	234	310394	157073	110121598
Bradyarrhythmia	58.86	10.10	71	310557	4863	110273808
Sinus bradycardia	58.30	10.10	199	310429	29284	110249387
Hypovolaemic shock	57.68	10.10	127	310501	14456	110264215
Reversible airways obstruction	57.16	10.10	51	310577	2448	110276223
Circulatory collapse	57.14	10.10	256	310372	42737	110235934
Memory impairment	57.02	10.10	322	310306	196622	110082049
Catheter management	56.88	10.10	61	310567	3674	110274997
Abdominal cavity drainage	56.51	10.10	34	310594	877	110277794
Acute myocardial infarction	56.39	10.10	416	310212	83361	110195310
Abdominal distension	56.29	10.10	745	309883	174358	110104313
Nodal rhythm	55.85	10.10	58	310570	3365	110275306
Dyspnoea paroxysmal nocturnal	55.14	10.10	50	310578	2452	110276219
Hypertension	55.09	10.10	1055	309573	509029	109769642
Atrial tachycardia	54.70	10.10	95	310533	9083	110269588
Blood alkaline phosphatase increased	54.64	10.10	364	310264	70571	110208100
Lung disorder	54.53	10.10	290	310338	179757	110098914
Body tinea	54.10	10.10	46	310582	2069	110276602
Waist circumference increased	54.09	10.10	43	310585	1758	110276913
Nipple pain	53.86	10.10	36	310592	1120	110277551
Ear infection	53.78	10.10	58	310570	62674	110215997
Injection site erythema	53.77	10.10	115	310513	94061	110184610
Therapeutic response decreased	53.31	10.10	120	310508	96379	110182292
Acute pulmonary oedema	53.09	10.10	135	310493	16861	110261810
Cirrhosis alcoholic	53.08	10.10	35	310593	1064	110277607
Blood aldosterone increased	53.02	10.10	21	310607	206	110278465
Cytomegalovirus infection	52.90	10.10	45	310583	54399	110224272
Electrocardiogram T wave peaked	52.85	10.10	36	310592	1156	110277515
N-terminal prohormone brain natriuretic peptide abnormal	52.26	10.10	23	310605	300	110278371
Blood loss anaemia	52.02	10.10	139	310489	17886	110260785
Intentional self-injury	51.95	10.10	20	310608	37409	110241262
Product label confusion	51.54	10.10	3	310625	22674	110255997
Lupus-like syndrome	51.53	10.10	25	310603	40767	110237904
Rhinitis allergic	51.52	10.10	138	310490	17784	110260887
Embolic stroke	51.46	10.10	90	310538	8653	110270018
Peritonitis bacterial	51.38	10.10	100	310528	10433	110268238
Drug tolerance decreased	51.21	10.10	8	310620	27532	110251139
Stress	51.17	10.10	140	310488	105208	110173463
Neck pain	51.01	10.10	176	310452	122954	110155717
Nephrectomy	50.94	10.10	49	310579	2591	110276080
Cor pulmonale	50.86	10.10	46	310582	2248	110276423
Frequent bowel movements	50.81	10.10	76	310552	71314	110207357
Psoriasis	50.30	10.10	212	310416	139781	110138890
Cytokine release syndrome	49.89	10.10	75	310553	70231	110208440
Hepatitis C	49.17	10.10	109	310519	12464	110266207
Suicide attempt	49.03	10.10	139	310489	103255	110175416
Sinoatrial block	48.38	10.10	37	310591	1428	110277243
Ventricular hypokinesia	48.19	10.10	101	310527	11113	110267558
Poisoning deliberate	48.17	10.10	8	310620	26323	110252348
Palpitations	48.14	10.10	670	309958	158542	110120129
Hypothyroidism	47.93	10.10	360	310268	72539	110206132
Ventricular internal diameter abnormal	47.92	10.10	20	310608	227	110278444
Chest pain	47.80	10.10	1390	309238	374985	109903686
Pain in extremity	47.67	10.10	1024	309604	486094	109792577
Atrioventricular block first degree	47.60	10.10	116	310512	14109	110264562
Blood creatine increased	47.47	10.10	102	310526	11419	110267252
Acute respiratory failure	47.44	10.10	368	310260	74892	110203779
Portal vein thrombosis	47.31	10.10	77	310551	6981	110271690
Insomnia	47.27	10.10	720	309908	359870	109918801
Left ventricular dilatation	47.15	10.10	36	310592	1386	110277285
Suicidal ideation	47.01	10.10	123	310505	93814	110184857
Atrial enlargement	46.90	10.10	33	310595	1118	110277553
Torsade de pointes	46.86	10.10	155	310473	22445	110256226
Gamma-glutamyltransferase increased	46.86	10.10	314	310314	60995	110217676
Dizziness postural	46.63	10.10	117	310511	14492	110264179
Catheter site infection	46.63	10.10	82	310546	7918	110270753
Concomitant disease progression	46.46	10.10	54	310574	3556	110275115
Chronic hepatic failure	46.20	10.10	34	310594	1237	110277434
Inhibitory drug interaction	46.13	10.10	63	310565	4884	110273787
Carpal tunnel syndrome	45.93	10.10	154	310474	22456	110256215
Presyncope	45.91	10.10	264	310364	48623	110230048
Jugular vein distension	45.17	10.10	37	310591	1579	110277092
Shock	44.96	10.10	281	310347	53307	110225364
Ventricular fibrillation	44.79	10.10	232	310396	41081	110237590
Spur cell anaemia	44.37	10.10	16	310612	118	110278553
Mucosal inflammation	44.31	10.10	131	310497	96010	110182661
Cerebral infarction	44.23	10.10	273	310355	51565	110227106
Loss of consciousness	44.13	10.10	786	309842	195520	110083151
Portal hypertensive gastropathy	43.77	10.10	39	310589	1869	110276802
Breast tenderness	43.56	10.10	45	310583	2595	110276076
Urinary retention	43.52	10.10	340	310288	69343	110209328
Respiratory failure	43.49	10.10	848	309780	214484	110064187
Subarachnoid haemorrhage	43.41	10.10	182	310446	29520	110249151
Hyperbilirubinaemia	43.32	10.10	186	310442	30485	110248186
Cardioversion	42.73	10.10	42	310586	2281	110276390
Asthma	42.66	10.10	473	310155	249818	110028853
Hypophagia	42.33	10.10	273	310355	52353	110226318
Aortic valve incompetence	41.60	10.10	94	310534	10887	110267784
Adrenal adenoma	41.37	10.10	34	310594	1458	110277213
Adverse reaction	40.77	10.10	16	310612	29578	110249093
Lichen planopilaris	40.67	10.10	16	310612	154	110278517
Drug ineffective for unapproved indication	40.59	10.10	150	310478	102688	110175983
Erysipelas	40.56	10.10	104	310524	13054	110265617
Liver function test increased	40.56	10.10	121	310507	88427	110190244
Dyspnoea at rest	40.42	10.10	79	310549	8267	110270404
Immunodeficiency	40.37	10.10	30	310598	38808	110239863
Haematuria	40.29	10.10	383	310245	82622	110196049
Electrocardiogram QRS complex prolonged	40.23	10.10	103	310525	12918	110265753
Oxygen saturation decreased	40.19	10.10	642	309986	156340	110122331
Azotaemia	40.08	10.10	88	310540	9997	110268674
Purpura	40.08	10.10	155	310473	24233	110254438
Ventricular extrasystoles	39.78	10.10	147	310481	22494	110256177
Device related infection	39.49	10.10	217	310411	39302	110239369
Neuropathy peripheral	39.45	10.10	318	310310	178959	110099712
Hepatomegaly	39.28	10.10	141	310487	21273	110257398
Cardiac output decreased	39.17	10.10	38	310590	2031	110276640
Haemoptysis	39.10	10.10	338	310290	71016	110207655
Hyperuricaemia	38.89	10.10	109	310519	14422	110264249
Progressive multifocal leukoencephalopathy	38.73	10.10	11	310617	24945	110253726
Neuroleptic malignant syndrome	38.49	10.10	24	310604	34035	110244636
Hypoalbuminaemia	38.11	10.10	172	310456	28802	110249869
Catheterisation cardiac	38.10	10.10	65	310563	6126	110272545
Sinus arrest	38.02	10.10	53	310575	4189	110274482
Exercise tolerance decreased	37.85	10.10	96	310532	11971	110266700
Peripheral circulatory failure	37.46	10.10	35	310593	1784	110276887
Agranulocytosis	37.28	10.10	299	310329	61461	110217210
Localised oedema	37.25	10.10	81	310547	9142	110269529
Blood pressure systolic decreased	37.14	10.10	102	310526	13339	110265332
Bronchial secretion retention	36.69	10.10	57	310571	4967	110273704
Gastric polyps	36.68	10.10	60	310568	5463	110273208
Oesophageal variceal ligation	36.60	10.10	15	310613	162	110278509
Adverse event	36.53	10.10	169	310459	108640	110170031
Blood urea abnormal	36.26	10.10	35	310593	1859	110276812
Multiple sclerosis relapse	36.23	10.10	53	310575	50187	110228484
Cardiorenal syndrome	35.88	10.10	35	310593	1883	110276788
Multiple allergies	35.83	10.10	95	310533	12168	110266503
Hyperthyroidism	35.75	10.10	170	310458	29091	110249580
Ulcer	35.71	10.10	41	310587	43075	110235596
Hyperglycaemia	35.70	10.10	381	310247	84709	110193962
Myocardial infarction	35.65	10.10	747	309881	191336	110087335
Ventricular arrhythmia	35.63	10.10	84	310544	10003	110268668
Laryngitis	35.48	10.10	40	310588	42371	110236300
Walking aid user	35.47	10.10	13	310615	25062	110253609
Transplant evaluation	35.30	10.10	34	310594	1801	110276870
Electrocardiogram change	35.06	10.10	30	310598	1361	110277310
Schizophrenia	35.04	10.10	9	310619	21817	110256854
Ear pain	34.74	10.10	60	310568	53166	110225505
Electrocardiogram T wave amplitude increased	34.71	10.10	12	310616	77	110278594
Generalised tonic-clonic seizure	34.46	10.10	63	310565	54617	110224054
Oxygen consumption increased	34.08	10.10	59	310569	5626	110273045
Infection susceptibility increased	33.67	10.10	51	310577	4347	110274324
Catheter placement	33.59	10.10	44	310584	3276	110275395
Endocarditis	33.56	10.10	98	310530	13273	110265398
Angina unstable	33.45	10.10	112	310516	16320	110262351
Diastolic dysfunction	33.15	10.10	93	310535	12311	110266360
Sudden cardiac death	33.14	10.10	58	310570	5579	110273092
Haemorrhage subcutaneous	32.57	10.10	57	310571	5482	110273189
Pulmonary veno-occlusive disease	32.57	10.10	35	310593	2113	110276558
Blood cholesterol	32.50	10.10	24	310604	878	110277793
Overdose	32.29	10.10	462	310166	233332	110045339
Blood pressure systolic increased	32.14	10.10	122	310506	82869	110195802
Sedation	32.07	10.10	95	310533	69588	110209083
Scrotal oedema	32.06	10.10	31	310597	1650	110277021
Asthenia	31.91	10.10	2296	308332	686703	109591968
Akathisia	31.76	10.10	5	310623	17108	110261563
Troponin T increased	31.65	10.10	49	310579	4257	110274414
Respiratory depression	31.64	10.10	26	310602	31975	110246696
Normal newborn	31.57	10.10	11	310617	21885	110256786
Eosinophilia	31.51	10.10	274	310354	57662	110221009
Left atrial dilatation	31.19	10.10	44	310584	3516	110275155
Cytomegalovirus viraemia	31.19	10.10	6	310622	17758	110260913
Dilatation ventricular	30.84	10.10	47	310581	4028	110274643
Blood test abnormal	30.71	10.10	160	310468	28394	110250277
Hypochloraemia	30.65	10.10	44	310584	3574	110275097
Blood cholesterol decreased	30.65	10.10	38	310590	2678	110275993
Cellulitis	30.63	10.10	511	310117	125505	110153166
International normalised ratio abnormal	30.58	10.10	60	310568	6297	110272374
Disability	30.58	10.10	24	310604	30199	110248472
Device alarm issue	30.50	10.10	36	310592	2410	110276261
Drug tolerance	30.43	10.10	5	310623	16580	110262091
Cardiac dysfunction	30.26	10.10	59	310569	6164	110272507
Neuroglycopenia	29.85	10.10	25	310603	1101	110277570
Rales	29.70	10.10	143	310485	24596	110254075
Hyperaldosteronism	29.56	10.10	20	310608	635	110278036
International normalised ratio decreased	29.54	10.10	69	310559	8167	110270504
Walking distance test abnormal	29.50	10.10	21	310607	725	110277946
Blood pressure abnormal	29.40	10.10	133	310495	22291	110256380
Chronic sinusitis	29.29	10.10	17	310611	25067	110253604
Lung transplant	29.29	10.10	53	310575	5233	110273438
Haemorrhoidal haemorrhage	29.25	10.10	68	310560	8025	110270646
Leukopenia	29.14	10.10	272	310356	148519	110130152
Catheter site erythema	29.12	10.10	57	310571	5971	110272700
Amnesia	29.08	10.10	175	310453	105233	110173438
Foetal death	29.08	10.10	5	310623	16040	110262631
Hypernatraemia	29.03	10.10	113	310515	17720	110260951
Platelet count normal	28.78	10.10	8	310620	21	110278650
Gouty arthritis	28.68	10.10	29	310599	1630	110277041
Peripartum cardiomyopathy	28.65	10.10	13	310615	183	110278488
Bronchopulmonary aspergillosis	28.62	10.10	25	310603	29838	110248833
Poor quality sleep	28.61	10.10	155	310473	27922	110250749
Gastric varices	28.59	10.10	22	310606	857	110277814
Altered state of consciousness	28.51	10.10	267	310361	57359	110221312
Thrombotic microangiopathy	28.43	10.10	24	310604	29125	110249546
Toxic epidermal necrolysis	28.15	10.10	263	310365	56464	110222207
Portopulmonary hypertension	28.01	10.10	12	310616	146	110278525
Protein-losing gastroenteropathy	28.00	10.10	22	310606	884	110277787
Bone marrow failure	28.00	10.10	77	310551	57771	110220900
Vascular resistance pulmonary decreased	27.94	10.10	10	310618	72	110278599
Neoplasm progression	27.66	10.10	91	310537	64504	110214167
Asterixis	27.63	10.10	39	310589	3119	110275552
Angina pectoris	27.58	10.10	282	310346	62013	110216658
Cyanosis	27.53	10.10	160	310468	29581	110249090
Oropharyngeal pain	27.49	10.10	245	310383	135031	110143640
Intra-abdominal fluid collection	27.47	10.10	43	310585	3771	110274900
Diaphragmatic spasm	27.33	10.10	11	310617	113	110278558
Proctitis	27.14	10.10	7	310621	16920	110261751
Poisoning	27.14	10.10	25	310603	29080	110249591
Abortion spontaneous	26.90	10.10	34	310594	34248	110244423
Sopor	26.90	10.10	38	310590	36508	110242163
Acidosis	26.88	10.10	130	310498	22401	110256270
Joint dislocation	26.74	10.10	34	310594	34156	110244515
Coma hepatic	26.68	10.10	23	310605	1054	110277617
Anal haemorrhage	26.62	10.10	49	310579	4903	110273768
Haemorrhagic disorder	26.54	10.10	29	310599	1784	110276887
Cardiac hypertrophy	26.53	10.10	30	310598	1917	110276754
Keratoconus	26.51	10.10	12	310616	168	110278503
Angiotensin converting enzyme inhibitor foetopathy	26.44	10.10	8	310620	31	110278640
Catheter site discharge	26.37	10.10	37	310591	2942	110275729
Right ventricular dilatation	26.30	10.10	33	310595	2354	110276317
Macular degeneration	26.27	10.10	14	310614	21645	110257026
Aspartate aminotransferase increased	26.19	10.10	611	310017	159325	110119346
Loss of personal independence in daily activities	26.15	10.10	282	310346	149738	110128933
Right ventricular dysfunction	26.10	10.10	39	310589	3284	110275387
Psychotic disorder	26.02	10.10	66	310562	50871	110227800
Fear of eating	25.95	10.10	17	310611	511	110278160
Amyloidosis	25.95	10.10	38	310590	3143	110275528
Venous pressure jugular increased	25.91	10.10	25	310603	1327	110277344
Blood potassium abnormal	25.91	10.10	43	310585	3962	110274709
Therapy partial responder	25.85	10.10	40	310588	37021	110241650
Hypotonia	25.82	10.10	100	310528	15645	110263026
Periarthritis calcarea	25.81	10.10	10	310618	92	110278579
Aspiration pleural cavity	25.80	10.10	28	310600	1709	110276962
Gastric ulcer	25.80	10.10	196	310432	39631	110239040
Pulmonary hypertensive crisis	25.65	10.10	16	310612	441	110278230
Temperature regulation disorder	25.57	10.10	3	310625	12823	110265848
Bilirubin conjugated increased	25.52	10.10	55	310573	6169	110272502
Conduction disorder	25.52	10.10	43	310585	4012	110274659
Osteonecrosis of jaw	25.48	10.10	61	310567	47956	110230715
Sedation complication	25.34	10.10	12	310616	19843	110258828
Blood creatinine abnormal	25.24	10.10	53	310575	5839	110272832
Drug resistance	25.13	10.10	78	310550	56296	110222375
Pulmonary arterial wedge pressure increased	25.12	10.10	18	310610	628	110278043
Cytomegalovirus infection reactivation	25.11	10.10	10	310618	18323	110260348
Stevens-Johnson syndrome	25.09	10.10	221	310407	46680	110231991
Injection site pruritus	24.98	10.10	68	310560	51190	110227481
Left ventricular hypertrophy	24.97	10.10	88	310540	13156	110265515
Catheter removal	24.97	10.10	18	310610	634	110278037
Ischaemic contracture of the left ventricle	24.89	10.10	11	310617	145	110278526
Peripheral swelling	24.89	10.10	906	309722	403128	109875543
Bronchiectasis	24.87	10.10	40	310588	36453	110242218
Contusion	24.74	10.10	484	310144	232877	110045794
Joint effusion	24.65	10.10	14	310614	20891	110257780
Female sexual arousal disorder	24.65	10.10	6	310622	7	110278664
Accidental exposure to product	24.62	10.10	66	310562	49942	110228729
Product administration error	24.58	10.10	184	310444	37033	110241638
COVID-19	24.56	10.10	513	310115	244547	110034124
Cerebral haemorrhage	24.56	10.10	285	310343	64683	110213988
Myasthenia gravis	24.53	10.10	15	310613	21496	110257175
Injection site swelling	24.47	10.10	90	310538	61700	110216971
Apparent mineralocorticoid excess	24.44	10.10	9	310619	71	110278600
Basal cell carcinoma	24.43	10.10	57	310571	45213	110233458
Respiratory symptom	24.31	10.10	6	310622	14939	110263732
Multiple-drug resistance	24.26	10.10	4	310624	13231	110265440
Therapeutic embolisation	24.24	10.10	17	310611	573	110278098
Feeling hot	24.22	10.10	153	310475	90953	110187718
Nephropathy	24.13	10.10	88	310540	13379	110265292
Thermohypoaesthesia	24.08	10.10	10	310618	112	110278559
Encephalopathy	24.05	10.10	340	310288	80715	110197956
Hypocalvaria	24.02	10.10	8	310620	45	110278626
White blood cell count decreased	23.94	10.10	477	310151	228913	110049758
Blood parathyroid hormone decreased	23.89	10.10	4	310624	13085	110265586
Hospitalisation	23.84	10.10	546	310082	141947	110136724
Tenosynovitis	23.79	10.10	8	310620	16275	110262396
Immune reconstitution inflammatory syndrome	23.66	10.10	8	310620	16218	110262453
Rhabdoid tumour	23.58	10.10	7	310621	25	110278646
Hypertrichosis	23.56	10.10	27	310601	1751	110276920
Bleeding varicose vein	23.53	10.10	18	310610	695	110277976
Blood glucose increased	23.52	10.10	512	310116	131984	110146687
Pericarditis constrictive	23.43	10.10	21	310607	1014	110277657
Upper respiratory tract inflammation	23.18	10.10	43	310585	4328	110274343
Gout	23.15	10.10	179	310449	36387	110242284
Pruritus	23.15	10.10	1367	309261	580193	109698478
Testicular swelling	23.14	10.10	26	310602	1650	110277021
Graft versus host disease	23.04	10.10	12	310616	18794	110259877
Porphyria acute	22.99	10.10	12	310616	18768	110259903
Musculoskeletal disorder	22.93	10.10	18	310610	22646	110256025
Calcium deficiency	22.92	10.10	22	310606	1160	110277511
Prostatomegaly	22.83	10.10	42	310586	4200	110274471
Renal artery stenosis	22.77	10.10	39	310589	3687	110274984
Colitis	22.73	10.10	181	310447	102142	110176529
Foreign body in reproductive tract	22.52	10.10	20	310608	954	110277717
Left atrial enlargement	22.46	10.10	26	310602	1705	110276966
Neutrophil count decreased	22.45	10.10	224	310404	120717	110157954
Blood pressure fluctuation	22.38	10.10	121	310507	74703	110203968
Fluid intake reduced	22.35	10.10	56	310572	6930	110271741
Left-to-right cardiac shunt	22.23	10.10	11	310617	190	110278481
Adrenal cyst	22.19	10.10	12	310616	251	110278420
Nodal arrhythmia	22.18	10.10	29	310599	2155	110276516
Decreased appetite	22.05	10.10	1586	309042	474260	109804411
Coordination abnormal	21.99	10.10	23	310605	25205	110253466
Blood sodium abnormal	21.97	10.10	23	310605	1347	110277324
Diarrhoea	21.87	10.10	3580	307048	1135925	109142746
Transplant rejection	21.86	10.10	22	310606	24545	110254126
Nephrogenic anaemia	21.78	10.10	43	310585	4534	110274137
Pneumonitis	21.67	10.10	126	310502	76405	110202266
Ectopic ACTH syndrome	21.53	10.10	11	310617	204	110278467
Primary hyperaldosteronism	21.49	10.10	12	310616	268	110278403
Aortic stenosis	21.46	10.10	83	310545	12976	110265695
Drug dose omission by device	21.44	10.10	7	310621	14509	110264162
Marasmus	21.27	10.10	25	310603	1666	110277005
Blood pressure systolic abnormal	21.27	10.10	23	310605	24827	110253844
Blood chloride decreased	21.17	10.10	65	310563	9050	110269621
Gastritis erosive	21.15	10.10	78	310550	11922	110266749
Mitral valve disease	21.13	10.10	36	310592	3389	110275282
Cough	21.10	10.10	1537	309091	460104	109818567
Occult blood positive	21.07	10.10	57	310571	7388	110271283
Abdominal pain upper	21.01	10.10	785	309843	348326	109930345
Haematotoxicity	21.00	10.10	17	310611	21065	110257606
Renal injury	20.92	10.10	106	310522	18607	110260064
Cortisol increased	20.91	10.10	16	310612	618	110278053
Blood albumin decreased	20.75	10.10	141	310487	27511	110251160
Acute myeloid leukaemia	20.55	10.10	48	310580	38062	110240609
Appendicitis	20.55	10.10	30	310598	28434	110250237
Multiple organ dysfunction syndrome	20.54	10.10	565	310063	151145	110127526
Vascular access site thrombosis	20.41	10.10	9	310619	118	110278553
Catheter site inflammation	20.21	10.10	21	310607	1219	110277452
Sputum culture	20.21	10.10	12	310616	302	110278369
Lower gastrointestinal haemorrhage	20.17	10.10	104	310524	18382	110260289
Nasal polyps	20.15	10.10	6	310622	13194	110265477
Hepatitis	20.14	10.10	159	310469	89895	110188776
Epstein-Barr virus infection	20.10	10.10	14	310614	18724	110259947
Injection site bruising	20.08	10.10	75	310553	51188	110227483
Duodenal ulcer	20.07	10.10	108	310520	19406	110259265
Vasodilatation	20.06	10.10	37	310591	3707	110274964
Radiculopathy	20.01	10.10	15	310613	19321	110259350
Upper-airway cough syndrome	20.01	10.10	93	310535	15764	110262907
Renin decreased	20.01	10.10	9	310619	124	110278547
Food allergy	19.98	10.10	16	310612	19932	110258739
BK virus infection	19.93	10.10	6	310622	13100	110265571
Muscle haemorrhage	19.85	10.10	53	310575	6816	110271855
Diabetic hyperosmolar coma	19.83	10.10	18	310610	884	110277787
Infected skin ulcer	19.76	10.10	38	310590	3929	110274742
Cardio-respiratory arrest	19.73	10.10	445	310183	115391	110163280
Colon cancer	19.70	10.10	95	310533	16348	110262323
Diffuse large B-cell lymphoma	19.69	10.10	10	310618	15888	110262783
Atrial thrombosis	19.68	10.10	40	310588	4306	110274365
Head injury	19.65	10.10	196	310432	42821	110235850
Cardiac pacemaker insertion	19.63	10.10	50	310578	6251	110272420
Cytopenia	19.61	10.10	34	310594	30082	110248589
Hydrocholecystis	19.54	10.10	15	310613	582	110278089
Acute graft versus host disease	19.40	10.10	6	310622	12875	110265796
Hyperhidrosis	19.38	10.10	390	310238	186908	110091763
Glycosylated haemoglobin increased	19.28	10.10	123	310505	23496	110255175
Faecal volume decreased	19.24	10.10	13	310615	412	110278259
ECG signs of myocardial ischaemia	19.15	10.10	13	310615	415	110278256
Malignant neoplasm progression	19.13	10.10	360	310268	174207	110104464
Gastric antral vascular ectasia	19.03	10.10	20	310608	1177	110277494
Panniculitis	19.01	10.10	10	310618	15572	110263099
Bronchial hyperreactivity	18.96	10.10	35	310593	3509	110275162
Respiratory distress	18.89	10.10	285	310343	68589	110210082
Blood pressure diastolic abnormal	18.84	10.10	27	310601	25788	110252883
Urogenital haemorrhage	18.81	10.10	18	310610	946	110277725
Toxic skin eruption	18.72	10.10	137	310491	27378	110251293
Catheter site haemorrhage	18.67	10.10	47	310581	5833	110272838
Peripheral arterial occlusive disease	18.67	10.10	63	310565	9217	110269454
Upper respiratory tract infection	18.66	10.10	258	310370	131070	110147601
Serotonin syndrome	18.62	10.10	94	310534	59059	110219612
Hepatorenal failure	18.61	10.10	21	310607	1339	110277332
Cardiac cirrhosis	18.45	10.10	11	310617	279	110278392
Blood sodium increased	18.44	10.10	45	310583	5478	110273193
Sight disability	18.29	10.10	10	310618	214	110278457
Xanthopsia	18.25	10.10	12	310616	363	110278308
Oxygen saturation increased	18.22	10.10	16	310612	752	110277919
Pulmonary artery dilatation	18.22	10.10	15	310613	645	110278026
Haemodialysis	18.17	10.10	98	310530	17621	110261050
Hidradenitis	18.15	10.10	43	310585	5137	110273534
Blood ketone body increased	18.12	10.10	17	310611	871	110277800
Vascular access site infection	18.11	10.10	9	310619	157	110278514
Acute left ventricular failure	18.07	10.10	27	310601	2274	110276397
Eosinophil count increased	18.03	10.10	111	310517	20947	110257724
Cardiac ventricular thrombosis	18.01	10.10	32	310596	3115	110275556
Electrocardiogram QRS complex abnormal	17.97	10.10	16	310612	766	110277905
Movement disorder	17.96	10.10	48	310580	36356	110242315
Right atrial dilatation	17.95	10.10	18	310610	1002	110277669
Infusion site reaction	17.94	10.10	14	310614	17668	110261003
Hypertrophic cardiomyopathy	17.89	10.10	32	310596	3131	110275540
Catheter site swelling	17.86	10.10	27	310601	2297	110276374
Splenomegaly	17.84	10.10	124	310504	24374	110254297
Erythema	17.83	10.10	654	309974	290793	109987878
Photophobia	17.80	10.10	28	310600	25743	110252928
Hypoperfusion	17.76	10.10	32	310596	3149	110275522
Tachypnoea	17.76	10.10	179	310449	39216	110239455
Platelet count decreased	17.64	10.10	804	309824	229639	110049032
Cardiac ablation	17.63	10.10	29	310599	2653	110276018
Cardiac murmur	17.55	10.10	124	310504	24504	110254167
Endometriosis male	17.50	10.10	5	310623	15	110278656
Hypocalcaemia	17.36	10.10	269	310359	65097	110213574
Dementia	17.33	10.10	150	310478	31523	110247148
Gastric varices haemorrhage	17.31	10.10	13	310615	488	110278183
Therapeutic drug monitoring analysis incorrectly performed	17.22	10.10	15	310613	697	110277974
Articular calcification	17.15	10.10	10	310618	243	110278428
Faeces discoloured	17.15	10.10	158	310470	33790	110244881
Heart sounds abnormal	17.15	10.10	21	310607	1461	110277210
Infected dermal cyst	17.07	10.10	20	310608	1328	110277343
Body mass index decreased	17.05	10.10	16	310612	820	110277851
Prescribed underdose	17.04	10.10	110	310518	65064	110213607
Premature delivery	16.99	10.10	38	310590	30594	110248077
Atrial septal defect repair	16.95	10.10	13	310615	504	110278167
Inguinal hernia	16.93	10.10	54	310574	7671	110271000
Brain oedema	16.91	10.10	39	310589	31059	110247612
Complication of device insertion	16.90	10.10	59	310569	8779	110269892
Therapeutic response increased	16.88	10.10	14	310614	608	110278063
Puncture site haemorrhage	16.87	10.10	15	310613	717	110277954
Atrioventricular block second degree	16.86	10.10	56	310572	8125	110270546
Prothrombin time ratio increased	16.84	10.10	11	310617	329	110278342
Hepatic neoplasm	16.82	10.10	35	310593	3832	110274839
Gonadotrophin deficiency	16.81	10.10	7	310621	79	110278592
Hypomania	16.80	10.10	4	310624	10206	110268465
Nephrocalcinosis	16.76	10.10	23	310605	1791	110276880
Seronegative arthritis	16.76	10.10	8	310620	13169	110265502
Senile dementia	16.72	10.10	10	310618	255	110278416
Acute on chronic liver failure	16.61	10.10	12	310616	424	110278247
Coma	16.59	10.10	232	310396	117637	110161034
Full blood count abnormal	16.58	10.10	235	310393	55817	110222854
NYHA classification	16.55	10.10	6	310622	45	110278626
Device difficult to use	16.55	10.10	17	310611	18788	110259883
Internal haemorrhage	16.54	10.10	64	310564	10007	110268664
Left ventricular enlargement	16.49	10.10	16	310612	855	110277816
Seizure	16.46	10.10	484	310144	220701	110057970
Visual impairment	16.39	10.10	272	310356	134156	110144515
Intervertebral disc degeneration	16.32	10.10	16	310612	18069	110260602
Premature labour	16.31	10.10	3	310625	9169	110269502
Influenza like illness	16.30	10.10	164	310464	88248	110190423
Sinus disorder	16.26	10.10	43	310585	32685	110245986
Left ventricular false tendon	16.22	10.10	6	310622	48	110278623
Cardiopulmonary failure	16.20	10.10	54	310574	7849	110270822
Right ventricular hypertrophy	16.19	10.10	22	310606	1697	110276974
Nocturnal dyspnoea	16.17	10.10	23	310605	1852	110276819
Vessel puncture site haemorrhage	16.16	10.10	9	310619	200	110278471
Nodule	16.12	10.10	43	310585	32588	110246083
Lethargy	16.10	10.10	360	310268	93216	110185455
Eosinophilic granulomatosis with polyangiitis	16.06	10.10	5	310623	10681	110267990
Dyskinesia	16.05	10.10	82	310546	51364	110227307
Overlap syndrome	16.03	10.10	3	310625	9056	110269615
Tricuspid valve replacement	16.02	10.10	5	310623	22	110278649
Red cell distribution width abnormal	16.02	10.10	10	310618	276	110278395
Blood pressure orthostatic	16.00	10.10	7	310621	90	110278581
Death	15.99	10.10	2218	308410	696651	109582020
Monocytosis	15.98	10.10	22	310606	1718	110276953
Hormone-dependent prostate cancer	15.96	10.10	9	310619	205	110278466
Ventricular dyssynchrony	15.93	10.10	7	310621	91	110278580
Hypoparathyroidism secondary	15.92	10.10	10	310618	279	110278392
Paradoxical drug reaction	15.85	10.10	4	310624	9813	110268858
Urine potassium increased	15.84	10.10	5	310623	23	110278648
Dilatation atrial	15.75	10.10	34	310594	3818	110274853
Glucose tolerance impaired	15.74	10.10	62	310566	9775	110268896
Pericardial calcification	15.70	10.10	6	310622	53	110278618
Posterior reversible encephalopathy syndrome	15.70	10.10	46	310582	33815	110244856
Stupor	15.66	10.10	55	310573	8210	110270461
Activated partial thromboplastin time shortened	15.63	10.10	17	310611	1040	110277631
Tricuspid valve disease	15.63	10.10	12	310616	466	110278205
Tendonitis	15.60	10.10	31	310597	26052	110252619
Heart transplant	15.59	10.10	21	310607	1607	110277064
Right ventricular systolic pressure increased	15.48	10.10	17	310611	1052	110277619
Preternatural anus	15.46	10.10	7	310621	98	110278573
Aggression	15.45	10.10	100	310528	59110	110219561
Chronic respiratory failure	15.45	10.10	34	310594	3869	110274802
Scrotal swelling	15.39	10.10	18	310610	1193	110277478
Bundle branch block	15.38	10.10	22	310606	1781	110276890
Electrocardiogram QT prolonged	15.37	10.10	408	310220	108552	110170119
Pulmonary vein stenosis	15.34	10.10	8	310620	155	110278516
Quadriparesis	15.34	10.10	38	310590	4669	110274002
Portal shunt procedure	15.34	10.10	5	310623	26	110278645
Symblepharon	15.32	10.10	12	310616	480	110278191
Prothrombin level decreased	15.31	10.10	22	310606	1788	110276883
Renal tubular acidosis	15.30	10.10	38	310590	4677	110273994
Hypoglycaemic coma	15.30	10.10	42	310586	5491	110273180
Procedural pain	15.30	10.10	50	310578	35515	110243156
Forced expiratory volume decreased	15.29	10.10	9	310619	13167	110265504
Haemothorax	15.28	10.10	49	310579	6982	110271689
Haemophagocytic lymphohistiocytosis	15.28	10.10	42	310586	31517	110247154
Hypoxia	15.25	10.10	474	310154	129041	110149630
Catastrophic reaction	15.18	10.10	5	310623	27	110278644
Hypochromic anaemia	15.14	10.10	30	310598	3171	110275500
Diet noncompliance	15.13	10.10	13	310615	593	110278078
Muscle spasms	15.10	10.10	633	309995	277524	110001147
Defect conduction intraventricular	15.09	10.10	14	310614	707	110277964
Bladder irrigation	15.05	10.10	6	310622	60	110278611
Glaucoma	15.05	10.10	25	310603	22492	110256179
Subcutaneous haematoma	15.02	10.10	29	310599	3007	110275664
Catheter site pain	15.00	10.10	46	310582	6400	110272271
Gender dysphoria	14.96	10.10	6	310622	61	110278610
Haemoglobin increased	14.92	10.10	58	310570	9089	110269582
Rash pruritic	14.90	10.10	190	310438	97879	110180792
Leukaemic infiltration renal	14.89	10.10	5	310623	29	110278642
Dermatitis contact	14.88	10.10	78	310550	13875	110264796
Device inappropriate shock delivery	14.87	10.10	6	310622	62	110278609
Hypertensive heart disease	14.87	10.10	37	310591	4559	110274112
Aspergillus infection	14.85	10.10	31	310597	25585	110253086
Right-to-left cardiac shunt	14.85	10.10	10	310618	315	110278356
Venous oxygen saturation decreased	14.71	10.10	6	310622	64	110278607
Oesophageal carcinoma	14.65	10.10	7	310621	11517	110267154
Cystitis haemorrhagic	14.65	10.10	8	310620	12201	110266470
Metastases to central nervous system	14.64	10.10	26	310602	22791	110255880
Myasthenic syndrome	14.63	10.10	18	310610	1258	110277413
Secondary sexual characteristics absence	14.63	10.10	3	310625	0	110278671
Immune effector cell-associated neurotoxicity syndrome	14.63	10.10	12	310616	14770	110263901
Exposure to toxic agent	14.61	10.10	9	310619	12849	110265822
Neurologic neglect syndrome	14.61	10.10	4	310624	9294	110269377
Uveitis	14.60	10.10	24	310604	21686	110256985
Adjustment disorder	14.60	10.10	6	310622	10789	110267882
Cardiac function test abnormal	14.60	10.10	8	310620	172	110278499
Haematocrit abnormal	14.57	10.10	21	310607	1712	110276959
Neurotoxicity	14.49	10.10	65	310563	42142	110236529
Synovial cyst	14.44	10.10	7	310621	11423	110267248
Activated partial thromboplastin time prolonged	14.44	10.10	110	310518	22258	110256413
Myocardial ischaemia	14.41	10.10	126	310502	26558	110252113
Mouth ulceration	14.31	10.10	78	310550	48060	110230611
Diffuse vasculitis	14.30	10.10	7	310621	118	110278553
Urine output increased	14.26	10.10	27	310601	2759	110275912
Device occlusion	14.25	10.10	82	310546	15103	110263568
Respiratory tract congestion	14.25	10.10	42	310586	30815	110247856
Scrotal infection	14.16	10.10	14	310614	766	110277905
Multiple sclerosis	14.15	10.10	32	310596	25666	110253005
Hepatotoxicity	14.15	10.10	112	310516	63288	110215383
Vascular device infection	14.11	10.10	87	310541	16425	110262246
Affect lability	14.09	10.10	19	310609	18618	110260053
Second primary malignancy	14.09	10.10	18	310610	18050	110260621
Haemorrhage	14.06	10.10	396	310232	106296	110172375
Prothrombin level increased	14.05	10.10	12	310616	543	110278128
Subchorionic haematoma	14.04	10.10	7	310621	123	110278548
QRS axis abnormal	14	10.10	25	310603	2443	110276228
Right atrial pressure increased	13.93	10.10	10	310618	350	110278321
Euglycaemic diabetic ketoacidosis	13.82	10.10	67	310561	11556	110267115
Hydrothorax	13.80	10.10	20	310608	1638	110277033
Hepatic calcification	13.80	10.10	10	310618	355	110278316
Infusion site pain	13.78	10.10	90	310538	17329	110261342
Extrasystoles	13.78	10.10	53	310575	8265	110270406
Labelled drug-disease interaction medication error	13.78	10.10	10	310618	356	110278315
Throat tightness	13.78	10.10	48	310580	33441	110245230
Stasis dermatitis	13.77	10.10	21	310607	1801	110276870
Mesenteric vein thrombosis	13.69	10.10	22	310606	1973	110276698
Blood culture negative	13.64	10.10	9	310619	274	110278397
Scleroderma	13.61	10.10	44	310584	6297	110272374
Neutropenic colitis	13.59	10.10	3	310625	8062	110270609
Chronic right ventricular failure	13.58	10.10	6	310622	79	110278592
Collateral circulation	13.58	10.10	6	310622	79	110278592
Walking disability	13.57	10.10	25	310603	2503	110276168
Bile acid malabsorption	13.56	10.10	11	310617	463	110278208
General symptom	13.54	10.10	4	310624	8842	110269829
Blood catecholamines decreased	13.53	10.10	4	310624	14	110278657
Coagulopathy	13.53	10.10	175	310453	40736	110237935
Thromboembolectomy	13.50	10.10	7	310621	134	110278537
Craniocerebral injury	13.49	10.10	42	310586	5892	110272779
Blood chloride increased	13.48	10.10	44	310584	6328	110272343
Dysuria	13.46	10.10	241	310387	59990	110218681
Cardiac pacemaker evaluation	13.45	10.10	7	310621	135	110278536
Drug withdrawal syndrome	13.43	10.10	58	310570	37996	110240675
Intracardiac thrombus	13.43	10.10	34	310594	4234	110274437
Nephrolithiasis	13.41	10.10	120	310508	66092	110212579
Fatigue	13.40	10.10	3119	307509	1212839	109065832
Peptic ulcer perforation	13.39	10.10	14	310614	819	110277852
Accelerated idioventricular rhythm	13.38	10.10	9	310619	283	110278388
Medication error	13.24	10.10	212	310416	105154	110173517
Alkalosis hypochloraemic	13.22	10.10	12	310616	589	110278082
Multiple drug therapy	13.22	10.10	51	310577	7963	110270708
Optic nerve operation	13.16	10.10	11	310617	483	110278188
Gastrointestinal vascular malformation haemorrhagic	13.16	10.10	15	310613	967	110277704
Demyelination	13.15	10.10	5	310623	9424	110269247
Bladder cancer	13.13	10.10	23	310605	20269	110258402
Bradypnoea	13.08	10.10	4	310624	8645	110270026
Immature granulocyte count increased	13.06	10.10	14	310614	843	110277828
Secretion discharge	13.05	10.10	23	310605	20221	110258450
Coronary artery bypass	13.03	10.10	42	310586	6000	110272671
Supraventricular extrasystoles	13.01	10.10	51	310577	8022	110270649
Metastases to nervous system	13.00	10.10	9	310619	297	110278374
Amaurosis	12.99	10.10	19	310609	1570	110277101
Alpha 1 foetoprotein increased	12.96	10.10	14	310614	850	110277821
Primary biliary cholangitis	12.93	10.10	18	310610	1421	110277250
Mass	12.93	10.10	22	310606	19608	110259063
Base excess decreased	12.90	10.10	10	310618	394	110278277
Wrong technique in product usage process	12.88	10.10	329	310299	87019	110191652
Cardiac failure high output	12.86	10.10	11	310617	499	110278172
Haemodynamic instability	12.84	10.10	109	310519	22779	110255892
Osteoporosis	12.82	10.10	170	310458	86982	110191689
Percussion test abnormal	12.81	10.10	5	310623	47	110278624
Postrenal failure	12.80	10.10	14	310614	862	110277809
Kidney transplant rejection	12.80	10.10	9	310619	11978	110266693
Gastritis	12.77	10.10	217	310411	53482	110225189
Cerebral artery embolism	12.77	10.10	22	310606	2090	110276581
Dystonia	12.75	10.10	34	310594	25771	110252900
Arterial stenosis	12.72	10.10	19	310609	1600	110277071
Prolactin-producing pituitary tumour	12.67	10.10	7	310621	153	110278518
Electrolyte depletion	12.67	10.10	11	310617	509	110278162
Inappropriate schedule of product administration	12.67	10.10	456	310172	203181	110075490
Steroid dependence	12.66	10.10	4	310624	8465	110270206
Haemorrhagic stroke	12.64	10.10	74	310554	13715	110264956
Subcutaneous drug absorption impaired	12.60	10.10	3	310625	7656	110271015
Hypomagnesaemia	12.60	10.10	239	310389	60131	110218540
Affective disorder	12.59	10.10	8	310620	11233	110267438
Blood pressure increased	12.58	10.10	595	310033	257778	110020893
Drug specific antibody present	12.58	10.10	4	310624	8430	110270241
Persistent foetal circulation	12.56	10.10	3	310625	3	110278668
Bronchopulmonary aspergillosis allergic	12.56	10.10	4	310624	8422	110270249
Child-Pugh-Turcotte score increased	12.54	10.10	5	310623	50	110278621
Spinal fusion surgery	12.53	10.10	5	310623	9151	110269520
Oxygen consumption decreased	12.53	10.10	11	310617	517	110278154
Encephalitis	12.51	10.10	21	310607	18818	110259853
Blood bilirubin unconjugated increased	12.49	10.10	16	310612	1165	110277506
Arteriovenous fistula	12.49	10.10	18	310610	1467	110277204
Injection site mass	12.49	10.10	32	310596	24581	110254090
Pulmonary capillary haemangiomatosis	12.48	10.10	6	310622	97	110278574
Substance abuse	12.48	10.10	10	310618	12453	110266218
Rhinitis	12.48	10.10	28	310600	22517	110256154
Headache	12.47	10.10	2235	308393	880142	109398529
Therapeutic response shortened	12.44	10.10	42	310586	29541	110249130
Gastroenteritis	12.42	10.10	165	310463	38635	110240036
Apheresis related complication	12.40	10.10	4	310624	20	110278651
Liver carcinoma ruptured	12.39	10.10	9	310619	321	110278350
Ventricular assist device insertion	12.37	10.10	5	310623	52	110278619
Macroangiopathy	12.35	10.10	7	310621	161	110278510
Dermatitis bullous	12.34	10.10	88	310540	17441	110261230
Duodenal ulcer haemorrhage	12.34	10.10	50	310578	7987	110270684
Brain stem stroke	12.33	10.10	13	310615	768	110277903
Atrial pressure increased	12.32	10.10	6	310622	100	110278571
Haematoma muscle	12.27	10.10	32	310596	4058	110274613
Withdrawal syndrome	12.23	10.10	46	310582	31334	110247337
Paranoia	12.21	10.10	28	310600	22346	110256325
Diabetic nephropathy	12.16	10.10	29	310599	3479	110275192
Hepatitis fulminant	12.16	10.10	52	310576	8508	110270163
Gamma-glutamyltransferase abnormal	12.15	10.10	14	310614	913	110277758
Breast pain	12.15	10.10	58	310570	9942	110268729
Brain natriuretic peptide	12.12	10.10	5	310623	55	110278616
Graft versus host disease in gastrointestinal tract	12.11	10.10	5	310623	8963	110269708
Ventricular failure	12.09	10.10	11	310617	542	110278129
Adenovirus infection	12.08	10.10	8	310620	10986	110267685
Hypertrophy	12.06	10.10	14	310614	921	110277750
Fractured sacrum	12.04	10.10	21	310607	2015	110276656
Blood phosphorus increased	12.01	10.10	17	310611	16323	110262348
Hepatic hydrothorax	12.00	10.10	6	310622	106	110278565
Supraventricular tachycardia	12.00	10.10	113	310515	24309	110254362
Personality disorder	12.00	10.10	11	310617	12826	110265845
Gingival pain	11.94	10.10	16	310612	15720	110262951
Catheter site scab	11.91	10.10	8	310620	251	110278420
Injection site haemorrhage	11.87	10.10	50	310578	32978	110245693
Costal cartilage fracture	11.85	10.10	8	310620	253	110278418
Malnutrition	11.84	10.10	123	310505	27156	110251515
Resting tremor	11.82	10.10	19	310609	1704	110276967
Ataxia	11.82	10.10	44	310584	30064	110248607
Urethral injury	11.81	10.10	5	310623	59	110278612
Cerebral haematoma	11.80	10.10	56	310572	9576	110269095
Insurance issue	11.78	10.10	60	310568	10552	110268119
Gait disturbance	11.76	10.10	650	309978	277558	110001113
Alcoholic liver disease	11.75	10.10	11	310617	562	110278109
Neurological symptom	11.71	10.10	16	310612	15592	110263079
Deformity	11.70	10.10	7	310621	10153	110268518
Emotional disorder	11.70	10.10	17	310611	16143	110262528
Acquired haemophilia	11.66	10.10	24	310604	2607	110276064
Blood albumin abnormal	11.53	10.10	13	310615	828	110277843
CSF protein abnormal	11.53	10.10	4	310624	26	110278645
Inferior vena cava syndrome	11.52	10.10	6	310622	116	110278555
Blood electrolytes abnormal	11.51	10.10	21	310607	2087	110276584
Infusion site erythema	11.50	10.10	65	310563	11894	110266777
Blood thyroid stimulating hormone abnormal	11.48	10.10	15	310613	1114	110277557
Paraesthesia oral	11.48	10.10	52	310576	33619	110245052
Central venous catheterisation	11.47	10.10	30	310598	3812	110274859
Pathogen resistance	11.46	10.10	20	310608	17652	110261019
Cardiac operation	11.45	10.10	40	310588	5955	110272716
Tremor	11.44	10.10	458	310170	201774	110076897
Catheter site abscess	11.40	10.10	8	310620	270	110278401
Type 3 diabetes mellitus	11.38	10.10	6	310622	119	110278552
Cryoglobulins present	11.35	10.10	3	310625	6	110278665
Portal vein pressure increased	11.35	10.10	3	310625	6	110278665
Intestinal varices haemorrhage	11.35	10.10	3	310625	6	110278665
CREST syndrome	11.35	10.10	10	310618	472	110278199
Cardiac asthma	11.32	10.10	8	310620	273	110278398
Choking	11.31	10.10	77	310551	15033	110263638
Anorectal varices	11.31	10.10	5	310623	66	110278605
Breast cancer female	11.28	10.10	11	310617	12457	110266214
Pulmonary arteriovenous fistula	11.27	10.10	4	310624	28	110278643
Infective pulmonary exacerbation of cystic fibrosis	11.23	10.10	15	310613	14756	110263915
Labelled drug-drug interaction issue	11.21	10.10	31	310597	4070	110274601
Perineal infection	11.21	10.10	13	310615	854	110277817
Pustular psoriasis	11.20	10.10	13	310615	13592	110265079
Adrenomegaly	11.19	10.10	10	310618	481	110278190
Osteopenia	11.17	10.10	29	310599	22180	110256491
Muscular weakness	11.16	10.10	577	310051	247891	110030780
Hyperphosphataemia	11.12	10.10	18	310610	16363	110262308
Coagulation factor increased	11.11	10.10	5	310623	69	110278602
Craniotomy	11.11	10.10	11	310617	603	110278068
Immobilisation syndrome	11.10	10.10	13	310615	863	110277808
Mycobacterium ulcerans infection	11.07	10.10	6	310622	126	110278545
Initial insomnia	11.02	10.10	58	310570	10331	110268340
Rash vesicular	11.02	10.10	15	310613	14637	110264034
Injection site warmth	11.01	10.10	20	310608	17385	110261286
Drug monitoring procedure not performed	11.01	10.10	16	310612	1314	110277357
Troponin increased	10.99	10.10	130	310498	29636	110249035
Osteonecrosis	10.97	10.10	53	310575	33688	110244983
Burns second degree	10.95	10.10	4	310624	7729	110270942
Eye pain	10.95	10.10	89	310539	50010	110228661
Haemorrhagic infarction	10.95	10.10	13	310615	876	110277795
Congenital arterial malformation	10.92	10.10	4	310624	31	110278640
Blood antidiuretic hormone increased	10.92	10.10	5	310623	72	110278599
Time perception altered	10.91	10.10	7	310621	203	110278468
Simple partial seizures	10.90	10.10	14	310614	1022	110277649
Diverticulitis intestinal haemorrhagic	10.86	10.10	10	310618	500	110278171
Septic shock	10.86	10.10	544	310084	156984	110121687
Catheter site rash	10.86	10.10	14	310614	1026	110277645
Rhinorrhoea	10.85	10.10	213	310415	102453	110176218
Intracranial aneurysm	10.84	10.10	35	310593	5005	110273666
Cutaneous vasculitis	10.83	10.10	67	310561	12662	110266009
Herpes zoster	10.82	10.10	227	310401	108152	110170519
Electrocardiogram P wave abnormal	10.81	10.10	9	310619	393	110278278
Pulmonary vascular resistance abnormality	10.79	10.10	7	310621	207	110278464
Tuberculosis	10.74	10.10	21	310607	17753	110260918
Body temperature increased	10.71	10.10	100	310528	54613	110224058
Glucose tolerance decreased	10.68	10.10	5	310623	76	110278595
Heart valve incompetence	10.66	10.10	30	310598	3979	110274692
Staphylococcus test positive	10.64	10.10	45	310583	7325	110271346
Nasal oedema	10.64	10.10	3	310625	6836	110271835
Traumatic haematoma	10.63	10.10	22	310606	2399	110276272
Hypocoagulable state	10.60	10.10	23	310605	2592	110276079
Blood corticotrophin increased	10.59	10.10	8	310620	303	110278368
Splinter haemorrhages	10.59	10.10	6	310622	138	110278533
Hyperglycaemic hyperosmolar nonketotic syndrome	10.57	10.10	25	310603	2984	110275687
Carotid artery occlusion	10.57	10.10	54	310574	9511	110269160
Coronary artery disease	10.56	10.10	270	310358	71420	110207251
Idiopathic angioedema	10.56	10.10	5	310623	78	110278593
Drug monitoring procedure incorrectly performed	10.56	10.10	12	310616	771	110277900
Diabetes mellitus inadequate control	10.54	10.10	129	310499	29646	110249025
Caesarean section	10.54	10.10	14	310614	13803	110264868
Rhythm idioventricular	10.54	10.10	12	310616	773	110277898
Pancreatitis chronic	10.52	10.10	32	310596	4433	110274238
Oral lichen planus	10.51	10.10	13	310615	914	110277757
Cryptogenic cirrhosis	10.50	10.10	5	310623	79	110278592
Univentricular heart	10.50	10.10	3	310625	9	110278662
Pancreatic enzymes decreased	10.50	10.10	3	310625	9	110278662
Blood bicarbonate decreased	10.49	10.10	38	310590	5759	110272912
Hypoosmolar state	10.49	10.10	9	310619	410	110278261
Gastric ulcer haemorrhage	10.47	10.10	56	310572	10038	110268633
Product storage error	10.45	10.10	29	310599	21699	110256972
Heart disease congenital	10.41	10.10	11	310617	651	110278020
Bulbospinal muscular atrophy congenital	10.40	10.10	4	310624	36	110278635
Prurigo	10.39	10.10	16	310612	1384	110277287
Volume blood decreased	10.38	10.10	9	310619	416	110278255
Hypoaesthesia oral	10.35	10.10	20	310608	16982	110261689
Prostate cancer metastatic	10.34	10.10	34	310594	4909	110273762
Immunoglobulins increased	10.33	10.10	12	310616	790	110277881
Diabetic neuropathy	10.31	10.10	43	310585	6956	110271715
Venous pressure increased	10.31	10.10	4	310624	37	110278634
Hypercapnia	10.31	10.10	60	310568	11099	110267572
Malignant ascites	10.30	10.10	16	310612	1394	110277277
Haemoconcentration	10.30	10.10	7	310621	224	110278447
Drug level decreased	10.29	10.10	23	310605	18525	110260146
Tachycardia induced cardiomyopathy	10.27	10.10	7	310621	225	110278446
Fractured coccyx	10.22	10.10	15	310613	1243	110277428
Pulmonary valve incompetence	10.18	10.10	23	310605	2663	110276008
Listeraemia	10.18	10.10	5	310623	85	110278586
Hypergammaglobulinaemia	10.17	10.10	13	310615	945	110277726
Cardiovascular insufficiency	10.15	10.10	26	310602	3262	110275409
Vasoplegia syndrome	10.14	10.10	36	310592	5403	110273268
Duplicate therapy error	10.12	10.10	9	310619	430	110278241
Fat intolerance	10.12	10.10	4	310624	39	110278632

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypocalvaria	36.09	24.96	9	136	40	113768
Generalised tonic-clonic seizure	30.18	24.96	10	135	139	113669

Pharmacologic Action:

Source	Code	Description
ATC	C03DA01	CARDIOVASCULAR SYSTEM DIURETICS ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS Aldosterone antagonists
FDA MoA	N0000011310	Aldosterone Antagonists
FDA EPC	N0000175557	Aldosterone Antagonist
MeSH PA	D000451	Mineralocorticoid Receptor Antagonists
MeSH PA	D004232	Diuretics
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D045283	Natriuretic Agents
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35498	diuretic
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:38070	anti-arrhythmia drug
CHEBI has role	CHEBI:50844	aldosterone antagonist
CHEBI has role	CHEBI:62868	hepatoprotective agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:78298	environmental contaminant
CHEBI has role	CHEBI:231911	renoprotective agent
CHEBI has role	CHEBI:233423	antifibrotic agent

Related Drugs by ATC class:

C03DA Aldosterone antagonists 5 drugs

canrenone dapagliflozin eplerenone finerenone potassium canrenoate

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Aldosteronism	indication	88213004	DOID:446
Edema	indication	267038008
Ascites	indication	389026000
Diagnostic Test for Primary Aldosteronism	indication
Hypokalemia Prevention	indication
Peripheral Edema due to Chronic Heart Failure	indication
Edema due to Hepatic Cirrhosis	indication
Edema due to Nephrotic Syndrome	indication
Pulmonary Edema due to Chronic Heart Failure	indication
Acne	off-label use	11381005	DOID:6543
Polycystic ovaries	off-label use	69878008
Anuria	contraindication	2472002	DOID:2983
Hypercholesterolemia	contraindication	13644009
Hyperkalemia	contraindication	14140009
Metabolic acidosis, normal anion gap, acidifying salts	contraindication	18104000
Secondary angle-closure glaucoma	contraindication	21571006
Hypovolemia	contraindication	28560003
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Sympathectomy	contraindication	57071006
Acute nephropathy	contraindication	58574008
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hypochloremic alkalosis	contraindication	70134007
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hypomagnesemia	contraindication	190855004
Acute pancreatitis	contraindication	197456007	DOID:2913
Neonatal hyperbilirubinemia	contraindication	281610001
Azotemia	contraindication	445009001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Cardalis	Ceva Sante Animale	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
25MG/5ML	CAROSPIR	CMP DEV LLC	N209478	Aug. 4, 2017	RX	SUSPENSION	ORAL	11395828	Oct. 28, 2036	CAROSPIR IS INDICATED AS AN ADD-ON THERAPY FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULT PATIENTS WHO ARE NOT ADEQUATELY CONTROLLED ON OTHER AGENTS
25MG/5ML	CAROSPIR	CMP DEV LLC	N209478	Aug. 4, 2017	RX	SUSPENSION	ORAL	11395828	Oct. 28, 2036	CAROSPIR IS INDICATED FOR THE MANAGEMENT OF EDEMA IN ADULT CIRRHOTIC PATIENTS WHEN EDEMA IS NOT RESPONSIVE TO FLUID AND SODIUM RESTRICTION
25MG/5ML	CAROSPIR	CMP DEV LLC	N209478	Aug. 4, 2017	RX	SUSPENSION	ORAL	11395828	Oct. 28, 2036	CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE
25MG/5ML	CAROSPIR	CMP DEV LLC	N209478	Aug. 4, 2017	RX	SUSPENSION	ORAL	9757394	Oct. 28, 2036	CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN	ANTAGONIST	IC50	9.88	WOMBAT-PK	CHEMBL
Nuclear receptor subfamily 1 group I member 2	Nuclear hormone receptor	O75469	NR1I2_HUMAN				WOMBAT-PK
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		Ki	7.40	CHEMBL
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		EC50	6.03	WOMBAT-PK
Estrogen receptor beta	Nuclear hormone receptor	Q92731	ESR2_HUMAN		EC50	5.48	CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.52	DRUG MATRIX
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		IC50	6.23	WOMBAT-PK
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	4.73	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		IC50	6.17	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	6.66	DRUG MATRIX

External reference:

ID	Source
4017881	VUID
N0000146234	NUI
D00443	KEGG_DRUG
4017881	VANDF
C0037982	UMLSCUI
CHEBI:9241	CHEBI
SNL	PDB_CHEM_ID
CHEMBL1393	ChEMBL_ID
D013148	MESH_DESCRIPTOR_UI
DB00421	DRUGBANK_ID
5833	PUBCHEM_CID
2875	IUPHAR_LIGAND_ID
987	INN_ID
27O7W4T232	UNII
151317	RXNORM
1558	MMSL
1587	MMSL
5506	MMSL
d00373	MMSL
002211	NDDF
13929005	SNOMEDCT_US
387078006	SNOMEDCT_US
27O7W4T232	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Aldactone	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1001	TABLET, FILM COATED	25 mg	ORAL	NDA	28 sections
Aldactone	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1031	TABLET, FILM COATED	100 mg	ORAL	NDA	28 sections
Aldactone	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1041	TABLET, FILM COATED	50 mg	ORAL	NDA	28 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0243	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Spironolactone and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0403	TABLET	25 mg	ORAL	ANDA	25 sections
Spironolactone and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0403	TABLET	25 mg	ORAL	ANDA	25 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0437	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-2146	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
SPIRONOLACTONE	HUMAN PRESCRIPTION DRUG LABEL	1	0574-1133	SUSPENSION	25 mg	ORAL	NDA authorized generic	25 sections
SPIRONOLACTONE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8451	TABLET	25 mg	ORAL	ANDA	25 sections
SPIRONOLACTONE	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8452	TABLET	50 mg	ORAL	ANDA	25 sections
spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6927	TABLET, FILM COATED	25 mg	ORAL	ANDA	24 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	10544-499	TABLET	25 mg	ORAL	ANDA	16 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	10544-523	TABLET	25 mg	ORAL	ANDA	16 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	16729-225	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	16729-226	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	16729-227	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
CaroSpir	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0120	Suspension	25 mg	ORAL	NDA	25 sections
SPIRONOLACTONE	HUMAN PRESCRIPTION DRUG LABEL	1	17856-1133	SUSPENSION	25 mg	ORAL	NDA authorized generic	25 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	17856-2028	SUSPENSION	25 mg	ORAL	ANDA	27 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	21695-766	TABLET	25 mg	ORAL	ANDA	26 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	21695-960	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	31722-094	TABLET, FILM COATED	25 mg	ORAL	ANDA	25 sections
spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	31722-095	TABLET, FILM COATED	50 mg	ORAL	ANDA	25 sections
spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	31722-096	TABLET, FILM COATED	100 mg	ORAL	ANDA	25 sections
spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	31722-691	SUSPENSION	25 mg	ORAL	ANDA	25 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	33261-764	TABLET, FILM COATED	100 mg	ORAL	ANDA	27 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	33261-869	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	33261-895	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Spironolactone	HUMAN PRESCRIPTION DRUG LABEL	1	42254-183	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections

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General architecture

Using the assistant

spironolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: