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paraoxon 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4683 | 311-45-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An organophosphate cholinesterase inhibitor that is used as a pesticide.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 66 | |||
| kinase-selectivity-class | AURKA,AXL,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK3,JAK1,JAK2,MAP2K3,MAP2K6,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,MET,MTOR,PDK4,PRKDC,SIK2,STK33,SYK,TEK,TTK,ZAP70 | 31 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EB10 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:38462 | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
Related Drugs by ATC class:
S01EB Parasympathomimetics 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Enzyme | IC50 | 7.23 | CHEMBL | |||||
| Carbonic anhydrase 1 | Enzyme | IC50 | 6.47 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 8 | CHEMBL | |||||
| Cholinesterase | Enzyme | IC50 | 8.15 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | IC50 | 5.99 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 7.89 | CHEMBL | |||||
| Cannabinoid receptor 1 | GPCR | IC50 | 5.92 | CHEMBL | |||||
| Monoglyceride lipase | Enzyme | IC50 | 5.92 | CHEMBL | |||||
| Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 6.27 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D10529 | KEGG_DRUG |
| CHEBI:27827 | CHEBI |
| CHEMBL23838 | ChEMBL_ID |
| DB13495 | DRUGBANK_ID |
| Q9CX8P80JW | UNII |
| C0030480 | UMLSCUI |
| D010261 | MESH_DESCRIPTOR_UI |
| 9395 | PUBCHEM_CID |
| C121104 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None