macrogol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4253 25322-68-3

Description:

MoleculeDescription

Synonyms:

  • polyethylene glycol
  • polyethylene glycol 3350
  • polyethylene glycol 400
  • polyethylene glycol 300
  • macrogol
  • macrogol 4000
  • Molecular weight:
  • Formula: (C2H4O)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 13, 1984 FDA BRAINTREE
Sept. 21, 2018 PMDA EA Pharma Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Constipation 690.58 9.73 1148 96474 279247 90251578
Macular degeneration 519.72 9.73 385 97237 37585 90493240
Febrile neutropenia 394.03 9.73 652 96970 157697 90373128
Pemphigus 326.43 9.73 5 97617 326859 90203966
Synovitis 317.47 9.73 8 97614 329744 90201081
Systemic lupus erythematosus 299.61 9.73 24 97598 361872 90168953
Hand deformity 289.89 9.73 6 97616 296356 90234469
Contraindicated product administered 277.23 9.73 17 97605 320122 90210703
Glossodynia 264.49 9.73 22 97600 321757 90209068
Pericarditis 241.14 9.73 12 97610 270139 90260686
Arthropathy 233.71 9.73 54 97568 366188 90164637
Chronic sinusitis 230.49 9.73 197 97425 23605 90507220
Infective pulmonary exacerbation of cystic fibrosis 226.37 9.73 140 97482 10139 90520686
Treatment failure 214.57 9.73 35 97587 303893 90226932
Rheumatoid arthritis 213.20 9.73 63 97559 362551 90168274
Helicobacter infection 205.93 9.73 9 97613 226841 90303984
Maternal exposure during pregnancy 195.12 9.73 72 97550 359991 90170834
Wound 194.60 9.73 44 97578 302936 90227889
Folliculitis 192.74 9.73 6 97616 204347 90326478
Joint swelling 187.63 9.73 160 97462 503140 90027685
Vaginal flatulence 183.83 9.73 133 97489 12505 90518320
Proctitis 174.27 9.73 139 97483 15120 90515705
Abdominal pain 173.69 9.73 864 96758 394857 90135968
Paraesthesia oral 172.31 9.73 191 97431 31468 90499357
Psoriatic arthropathy 171.10 9.73 22 97600 228313 90302512
Swelling 169.03 9.73 123 97499 418935 90111890
Female genital tract fistula 167.14 9.73 145 97477 17723 90513102
Therapeutic product effect decreased 161.69 9.73 49 97573 277522 90253303
Vaginal discharge 158.39 9.73 146 97476 19318 90511507
Procedural pain 155.84 9.73 186 97436 33174 90497651
Radiculopathy 154.86 9.73 141 97481 18364 90512461
Colitis 154.02 9.73 273 97349 69669 90461156
Creatinine renal clearance decreased 135.18 9.73 132 97490 18767 90512058
Alopecia 134.77 9.73 203 97419 494868 90035957
Hepatic enzyme increased 133.94 9.73 115 97507 360621 90170204
Urinary tract infection 133.05 9.73 666 96956 304966 90225859
Discomfort 129.35 9.73 67 97555 274268 90256557
Lower respiratory tract infection 129.33 9.73 54 97568 250605 90280220
Liver injury 128.82 9.73 16 97606 170551 90360274
Sedation complication 128.08 9.73 122 97500 16822 90514003
Blood calcium decreased 127.57 9.73 160 97462 30022 90500803
Aplastic anaemia 126.78 9.73 109 97513 13160 90517665
Sleep disorder due to general medical condition, insomnia type 124.22 9.73 3 97619 128691 90402134
Impaired healing 123.19 9.73 49 97573 234150 90296675
Dehydration 118.86 9.73 469 97153 193978 90336847
Irritable bowel syndrome 116.55 9.73 39 97583 207409 90323416
Exposure during pregnancy 115.73 9.73 56 97566 238354 90292471
Type 2 diabetes mellitus 111.10 9.73 40 97582 203204 90327621
Drug hypersensitivity 104.46 9.73 214 97408 463395 90067430
Joint range of motion decreased 104.21 9.73 12 97610 135631 90395194
Drug intolerance 103.93 9.73 203 97419 447388 90083437
Oral candidiasis 103.21 9.73 157 97465 35298 90495527
Abdominal discomfort 102.82 9.73 226 97396 477102 90053723
Blister 102.52 9.73 75 97547 254923 90275902
Ill-defined disorder 101.71 9.73 36 97586 184855 90345970
Anaemia 99.69 9.73 686 96936 352116 90178709
Orthostatic hypotension 98.24 9.73 168 97454 41659 90489166
Mental status changes 92.74 9.73 170 97452 44509 90486316
Nausea 92.28 9.73 1692 95930 1108624 89422201
Fall 91.91 9.73 856 96766 480954 90049871
Fibromyalgia 90.54 9.73 55 97567 206214 90324611
Haematochezia 90.28 9.73 221 97401 70692 90460133
Inflammation 89.67 9.73 40 97582 178552 90352273
Musculoskeletal stiffness 89.22 9.73 113 97509 296419 90234406
Facet joint syndrome 88.93 9.73 4 97618 98385 90432440
Lip dry 85.42 9.73 6 97616 100949 90429876
Arthralgia 84.32 9.73 493 97129 778029 89752796
Blood cholesterol increased 81.26 9.73 63 97559 207949 90322876
Completed suicide 78.49 9.73 29 97593 145029 90385796
Urticaria 77.72 9.73 136 97486 312598 90218227
Death 76.22 9.73 789 96833 455762 90075063
Balance disorder 76.10 9.73 254 97368 96826 90433999
Nasopharyngitis 74.91 9.73 209 97413 406895 90123930
Plasma cell myeloma 74.42 9.73 147 97475 40681 90490144
Weight decreased 74.41 9.73 679 96943 379231 90151594
Sedation 74.39 9.73 162 97460 48009 90482816
Renal function test abnormal 70.59 9.73 60 97562 7131 90523694
Bursitis 70.10 9.73 27 97595 131627 90399198
Intestinal obstruction 69.27 9.73 135 97487 36996 90493829
Hypotension 69.09 9.73 592 97030 324805 90206020
Condition aggravated 68.27 9.73 370 97252 595175 89935650
Creatinine renal clearance increased 67.99 9.73 43 97579 3238 90527587
Cognitive disorder 67.74 9.73 196 97426 69211 90461614
Drug ineffective 66.94 9.73 1070 96552 1383228 89147597
Frequent bowel movements 66.77 9.73 172 97450 56763 90474062
Grip strength decreased 66.76 9.73 10 97612 92566 90438259
Sepsis 66.61 9.73 375 97247 179439 90351386
General physical health deterioration 65.54 9.73 182 97440 354933 90175892
Peripheral venous disease 65.52 9.73 7 97615 83914 90446911
Hypercholesterolaemia 64.02 9.73 15 97607 100877 90429948
Autoimmune disorder 63.67 9.73 5 97617 76739 90454086
Infection 63.59 9.73 190 97432 361904 90168921
C-reactive protein increased 63.47 9.73 61 97561 181328 90349497
Product use issue 63.20 9.73 166 97456 329753 90201072
Seizure 63.08 9.73 328 97294 152301 90378524
Rectal haemorrhage 60.91 9.73 212 97410 82532 90448293
Acute respiratory failure 60.29 9.73 139 97483 42779 90488046
Hypersensitivity 59.83 9.73 269 97353 454408 90076417
Depressed level of consciousness 59.33 9.73 193 97429 72591 90458234
Live birth 58.32 9.73 8 97614 79099 90451726
Rash 56.40 9.73 567 97055 795533 89735292
Colitis ulcerative 55.77 9.73 167 97455 60099 90470726
Stomatitis 55.09 9.73 135 97487 274563 90256262
Pulmonary embolism 53.27 9.73 280 97342 130540 90400285
Failure to thrive 53.26 9.73 55 97567 8356 90522469
Swollen tongue 53.03 9.73 138 97484 45818 90485007
Hyponatraemia 51.78 9.73 282 97340 133256 90397569
Wound infection 51.59 9.73 25 97597 106377 90424448
Pulmonary fibrosis 51.00 9.73 26 97596 107477 90423348
Red blood cell sedimentation rate increased 51.00 9.73 13 97609 82582 90448243
Intentional product use issue 50.58 9.73 98 97524 216794 90314031
Upper gastrointestinal haemorrhage 49.68 9.73 89 97533 22887 90507938
Malnutrition 49.57 9.73 79 97543 18479 90512346
Obesity 49.34 9.73 26 97596 105481 90425344
Abdominal distension 48.77 9.73 273 97349 130328 90400497
Faecaloma 48.44 9.73 58 97564 10373 90520452
Infusion related reaction 48.21 9.73 258 97364 416522 90114303
Gastrointestinal disorder 47.75 9.73 131 97491 256556 90274269
Sleep disorder 46.59 9.73 89 97533 197941 90332884
Injury 46.17 9.73 89 97533 197260 90333565
Small intestinal obstruction 45.59 9.73 82 97540 21152 90509673
Therapy non-responder 45.50 9.73 48 97574 136656 90394169
Hospice care 45.14 9.73 54 97568 9650 90521175
Blepharospasm 44.93 9.73 4 97618 55441 90475384
Liver disorder 44.53 9.73 39 97583 121230 90409595
Dysphonia 44.16 9.73 159 97463 62925 90467900
Platelet count decreased 43.86 9.73 275 97347 136694 90394131
Adjustment disorder with depressed mood 43.63 9.73 5 97617 56748 90474077
Transfusion 43.39 9.73 72 97550 17416 90513409
Blood potassium decreased 42.98 9.73 131 97491 47596 90483229
Hypoxia 42.87 9.73 173 97449 72226 90458599
Psoriasis 42.66 9.73 58 97564 147696 90383129
Intentional overdose 42.60 9.73 24 97598 93810 90437015
Deep vein thrombosis 42.15 9.73 203 97419 91417 90439408
Osteoarthritis 40.97 9.73 94 97528 195636 90335189
Gastrointestinal motility disorder 40.70 9.73 41 97581 6050 90524775
Wheezing 40.29 9.73 127 97495 237953 90292872
Prescribed overdose 40.14 9.73 28 97594 97597 90433228
Hip arthroplasty 39.95 9.73 16 97606 76192 90454633
Asthenia 39.81 9.73 801 96821 532950 89997875
Weight increased 38.81 9.73 277 97345 417650 90113175
Pleural effusion 37.84 9.73 228 97394 111763 90419062
X-ray abnormal 37.57 9.73 3 97619 45421 90485404
Clostridium test positive 37.27 9.73 37 97585 5364 90525461
Respiratory distress 37.05 9.73 109 97513 38837 90491988
Hypophagia 36.53 9.73 103 97519 35834 90494991
White blood cell count decreased 36.45 9.73 306 97316 166803 90364022
Peripheral swelling 36.35 9.73 278 97344 412828 90117997
Gait inability 36.06 9.73 64 97558 146392 90384433
Night sweats 35.73 9.73 52 97570 128714 90402111
Lethargy 35.12 9.73 148 97474 62991 90467834
Impaired gastric emptying 34.86 9.73 55 97567 12754 90518071
Lung disorder 34.70 9.73 68 97554 149815 90381010
Coeliac disease 34.12 9.73 4 97618 44606 90486219
Knee arthroplasty 34.01 9.73 24 97598 83158 90447667
Medication error 33.86 9.73 25 97597 84627 90446198
Lupus-like syndrome 33.60 9.73 6 97616 48840 90481985
Exostosis 33.51 9.73 8 97614 53126 90477699
Sciatica 33.28 9.73 36 97586 101346 90429479
Hospitalisation 33.13 9.73 244 97378 127856 90402969
Anal incontinence 32.72 9.73 61 97561 16169 90514656
Cytokine release syndrome 32.27 9.73 84 97538 27889 90502936
Musculoskeletal pain 32.13 9.73 87 97535 171164 90359661
Bacteraemia 31.07 9.73 72 97550 22228 90508597
Multiple drug therapy 30.97 9.73 38 97584 6971 90523854
Onychomadesis 30.89 9.73 6 97616 45992 90484833
Proctalgia 30.79 9.73 41 97581 8157 90522668
Flatulence 30.44 9.73 106 97516 41261 90489564
Lower limb fracture 30.42 9.73 28 97594 84985 90445840
Adverse event 30.11 9.73 50 97572 117368 90413457
Full blood count decreased 30.09 9.73 85 97537 29604 90501221
Decubitus ulcer 29.80 9.73 49 97573 11764 90519061
Swelling face 29.66 9.73 169 97453 81183 90449642
Back pain 28.83 9.73 491 97131 316684 90214141
Chronic obstructive pulmonary disease 28.66 9.73 156 97466 73673 90457152
Nail disorder 28.44 9.73 14 97608 59053 90471772
Neuropathy peripheral 28.39 9.73 248 97374 136722 90394103
Blood sodium decreased 27.93 9.73 79 97543 27534 90503291
Foot deformity 27.45 9.73 15 97607 59636 90471189
Rhinovirus infection 27.44 9.73 33 97589 5930 90524895
Sinusitis 26.92 9.73 238 97384 342850 90187975
Atelectasis 26.84 9.73 72 97550 24337 90506488
Injection site reaction 26.72 9.73 36 97586 92044 90438781
Eye irritation 26.70 9.73 89 97533 33889 90496936
Pyrexia 26.39 9.73 913 96709 659572 89871253
Hip fracture 26.31 9.73 87 97535 32990 90497835
Cardiac failure congestive 26.09 9.73 189 97433 98505 90432320
Peritonitis bacterial 26.09 9.73 30 97592 5141 90525684
Contusion 26.07 9.73 161 97461 251055 90279770
Oedema 25.99 9.73 119 97503 200176 90330649
Respiratory failure 25.90 9.73 217 97405 118201 90412624
Back injury 25.76 9.73 9 97613 46613 90484212
Disease progression 25.73 9.73 270 97352 156345 90374480
Neutrophil count decreased 25.68 9.73 148 97474 71384 90459441
Haemorrhoids 25.66 9.73 75 97547 26627 90504198
Hypertension 25.63 9.73 343 97279 457189 90073636
Myelosuppression 25.36 9.73 13 97609 53578 90477247
Atrial fibrillation 25.18 9.73 237 97385 133374 90397451
Eye pain 24.93 9.73 104 97518 44064 90486761
Hepatic cirrhosis 24.88 9.73 19 97603 63234 90467591
Road traffic accident 24.76 9.73 49 97573 107577 90423248
Haemoglobin decreased 24.66 9.73 275 97347 161681 90369144
Abortion spontaneous 24.28 9.73 14 97608 54042 90476783
Pregnancy 23.95 9.73 19 97603 62028 90468797
Abdominal pain lower 23.67 9.73 79 97543 30098 90500727
Escherichia bacteraemia 23.59 9.73 30 97592 5705 90525120
Cystic fibrosis 23.58 9.73 25 97597 3916 90526909
Foreign body sensation in eyes 23.50 9.73 23 97599 3277 90527548
Hepatitis 23.35 9.73 25 97597 70714 90460111
Pruritus 23.24 9.73 427 97195 541098 89989727
Neutropenia 22.97 9.73 355 97267 224549 90306276
Vomiting 22.94 9.73 1053 96569 787240 89743585
Encephalopathy 22.89 9.73 105 97517 46339 90484486
Anticoagulant therapy 22.89 9.73 13 97609 804 90530021
Carbon dioxide decreased 22.72 9.73 21 97601 2787 90528038
Product complaint 22.68 9.73 47 97575 13453 90517372
Analgesic therapy 22.42 9.73 12 97610 660 90530165
Pneumonia 22.32 9.73 869 96753 637190 89893635
Joint stiffness 22.15 9.73 31 97591 78011 90452814
Epilepsy 22.02 9.73 34 97588 82172 90448653
Tremor 21.49 9.73 256 97366 152917 90377908
Neurogenic bladder 21.42 9.73 23 97599 3655 90527170
Urinary retention 21.40 9.73 89 97533 37655 90493170
Large intestinal obstruction 21.38 9.73 20 97602 2694 90528131
Instillation site pain 21.32 9.73 13 97609 917 90529908
Antacid therapy 21.13 9.73 12 97610 742 90530083
Appendicolith 21.03 9.73 12 97610 749 90530076
Onychomycosis 21.02 9.73 7 97615 37369 90493456
Hypoaesthesia 20.85 9.73 227 97395 313983 90216842
Migraine 20.81 9.73 120 97502 190272 90340553
Finger deformity 20.65 9.73 5 97617 32892 90497933
Dysphagia 20.58 9.73 198 97424 112080 90418745
Hepatotoxicity 20.41 9.73 12 97610 45830 90484995
Rectal prolapse 20.40 9.73 18 97604 2249 90528576
Drug therapy 20.34 9.73 12 97610 797 90530028
Enterovirus infection 20.28 9.73 15 97607 1459 90529366
Pneumonia viral 20.14 9.73 35 97587 8788 90522037
Drug tolerance decreased 19.94 9.73 5 97617 32125 90498700
Feeling abnormal 19.86 9.73 271 97351 166964 90363861
International normalised ratio increased 19.75 9.73 102 97520 47214 90483611
Hypokalaemia 19.67 9.73 222 97400 130894 90399931
Urinary tract infection enterococcal 19.60 9.73 20 97602 2996 90527829
Fumbling 19.59 9.73 7 97615 142 90530683
Gastrointestinal haemorrhage 19.53 9.73 165 97457 90083 90440742
Product odour abnormal 19.42 9.73 15 97607 1556 90529269
Thrombocytopenia 19.27 9.73 324 97298 208401 90322424
Cellulitis 19.24 9.73 166 97456 91171 90439654
Noninfectious peritonitis 19.23 9.73 7 97615 150 90530675
Dementia 19.19 9.73 63 97559 23798 90507027
Product taste abnormal 19.14 9.73 18 97604 2442 90528383
Paraesthesia 19.03 9.73 175 97447 250151 90280674
Angioedema 18.77 9.73 127 97495 64749 90466076
Haematocrit decreased 18.74 9.73 92 97530 41740 90489085
Streptococcal bacteraemia 18.69 9.73 17 97605 2210 90528615
Dysuria 18.62 9.73 88 97534 39313 90491512
Vision blurred 18.52 9.73 191 97431 110102 90420723
Embolism 18.33 9.73 35 97587 9446 90521379
Venous pressure jugular increased 18.04 9.73 10 97612 590 90530235
Hyperlipidaemia 17.98 9.73 60 97562 22856 90507969
Hyponatraemic encephalopathy 17.84 9.73 8 97614 298 90530527
Drug-induced liver injury 17.61 9.73 45 97577 90273 90440552
Pelvic kidney 17.51 9.73 6 97616 107 90530718
Chills 17.39 9.73 218 97404 131763 90399062
Adenocarcinoma of colon 17.14 9.73 18 97604 2788 90528037
Urinary incontinence 17.10 9.73 83 97539 37483 90493342
Lymphocyte count decreased 17.09 9.73 79 97543 34971 90495854
Loss of personal independence in daily activities 16.98 9.73 82 97540 136023 90394802
Pseudohyponatraemia 16.81 9.73 5 97617 55 90530770
Foetal exposure during pregnancy 16.79 9.73 13 97609 42962 90487863
Clostridium difficile colitis 16.76 9.73 65 97557 26641 90504184
Leukocytosis 16.73 9.73 72 97550 30918 90499907
Productive cough 16.73 9.73 141 97481 76922 90453903
Visceral pain 16.54 9.73 4 97618 18 90530807
Distal intestinal obstruction syndrome 16.50 9.73 9 97613 514 90530311
Device expulsion 16.44 9.73 12 97610 40874 90489951
Bowel movement irregularity 16.40 9.73 27 97595 6487 90524338
Pneumonia aspiration 16.22 9.73 87 97535 40853 90489972
Hyperphosphataemia 16.20 9.73 20 97602 3691 90527134
Syncope 16.16 9.73 216 97406 132447 90398378
Cardiomyopathy 15.94 9.73 53 97569 20153 90510672
Unresponsive to stimuli 15.78 9.73 82 97540 38039 90492786
Salivary gland enlargement 15.69 9.73 8 97614 398 90530427
Diverticulum 15.67 9.73 38 97584 12075 90518750
Mucosal inflammation 15.60 9.73 111 97511 57514 90473311
Laryngitis 15.60 9.73 19 97603 50734 90480091
Eyelid pain 15.57 9.73 10 97612 773 90530052
Troponin increased 15.44 9.73 40 97582 13241 90517584
Red blood cell count decreased 15.41 9.73 94 97528 46257 90484568
Blood phosphorus increased 15.31 9.73 21 97601 4297 90526528
Dry mouth 15.17 9.73 126 97496 183933 90346892
Tricuspid valve disease 15.10 9.73 7 97615 282 90530543
Faeces hard 15.01 9.73 18 97604 3224 90527601
Drug resistance 14.99 9.73 7 97615 30442 90500383
Arthritis 14.97 9.73 112 97510 167203 90363622
Blood sodium abnormal 14.94 9.73 10 97612 829 90529996
Walking aid user 14.84 9.73 10 97612 35496 90495329
Oedema peripheral 14.76 9.73 373 97249 257542 90273283
Biliary dyskinesia 14.69 9.73 16 97606 2583 90528242
Dyspepsia 14.59 9.73 297 97325 197863 90332962
End stage renal disease 14.59 9.73 30 97592 8541 90522284
Neurogenic bowel 14.54 9.73 6 97616 182 90530643
Sinus tachycardia 14.45 9.73 65 97557 28448 90502377
Escherichia urinary tract infection 14.44 9.73 40 97582 13775 90517050
Blood loss anaemia 14.41 9.73 33 97589 10107 90520718
Adverse reaction 14.37 9.73 7 97615 29705 90501120
Adverse drug reaction 14.16 9.73 71 97551 116630 90414195
Bladder disorder 14.16 9.73 34 97588 10738 90520087
Asthma 14.11 9.73 180 97442 241980 90288845
Product administered to patient of inappropriate age 14.10 9.73 21 97601 4632 90526193
Gastritis 14.09 9.73 85 97537 41668 90489157
Hydronephrosis 14.06 9.73 37 97585 12365 90518460
Hyponatraemic seizure 13.98 9.73 8 97614 502 90530323
Cardiac murmur 13.71 9.73 47 97575 18147 90512678
Aspartate aminotransferase increased 13.55 9.73 170 97452 102767 90428058
Staphylococcal infection 13.52 9.73 94 97528 48345 90482480
Musculoskeletal chest pain 13.46 9.73 56 97566 23694 90507131
Electrocardiogram ST segment elevation 13.44 9.73 19 97603 3997 90526828
Joint dislocation 13.37 9.73 17 97605 44565 90486260
Carbohydrate antigen 125 increased 13.30 9.73 17 97605 3249 90527576
Bone pain 13.24 9.73 113 97509 61870 90468955
Kyphosis 13.23 9.73 16 97606 2892 90527933
Spleen atrophy 13.21 9.73 4 97618 47 90530778
Colitis ischaemic 13.15 9.73 36 97586 12310 90518515
Hyperglycaemia 13.12 9.73 97 97525 50873 90479952
Ascites 12.95 9.73 92 97530 47648 90483177
Blood phosphorus decreased 12.86 9.73 21 97601 5013 90525812
Breath sounds abnormal 12.71 9.73 41 97581 15345 90515480
Prescribed underdose 12.69 9.73 40 97582 74979 90455846
Blood calcium increased 12.69 9.73 35 97587 12023 90518802
Blood alkaline phosphatase increased 12.66 9.73 92 97530 47987 90482838
Erythema 12.66 9.73 330 97292 228916 90301909
Injection site pain 12.53 9.73 123 97499 173576 90357249
Fibula agenesis 12.50 9.73 4 97618 57 90530768
Delayed haemolytic transfusion reaction 12.50 9.73 3 97619 13 90530812
Spina bifida occulta 12.44 9.73 4 97618 58 90530767
Platelet transfusion 12.36 9.73 10 97612 1110 90529715
Paraneoplastic dermatomyositis 12.36 9.73 5 97617 144 90530681
Urinary tract infection staphylococcal 12.31 9.73 7 97615 434 90530391
Non-small cell lung cancer 12.18 9.73 19 97603 4362 90526463
Head injury 12.17 9.73 66 97556 31122 90499703
Calculus bladder 12.07 9.73 8 97614 653 90530172
Mean platelet volume increased 12.05 9.73 9 97613 888 90529937
Oesophageal achalasia 11.99 9.73 8 97614 660 90530165
Premature baby 11.99 9.73 6 97616 25071 90505754
Pulmonary function test decreased 11.82 9.73 19 97603 4475 90526350
Intracranial pressure increased 11.78 9.73 24 97598 6787 90524038
Hypophosphataemia 11.75 9.73 39 97583 14815 90516010
Disability 11.75 9.73 16 97606 40729 90490096
Pustule 11.73 9.73 15 97607 2868 90527957
Listeraemia 11.69 9.73 4 97618 71 90530754
Mental disorder 11.68 9.73 67 97555 32251 90498574
Electrocardiogram QRS complex prolonged 11.67 9.73 25 97597 7323 90523502
Lower gastrointestinal haemorrhage 11.62 9.73 28 97594 8864 90521961
Pubic pain 11.55 9.73 5 97617 171 90530654
Presyncope 11.54 9.73 66 97556 31739 90499086
Blood albumin decreased 11.46 9.73 42 97580 16761 90514064
Foetal death 11.45 9.73 4 97618 20719 90510106
Thrombosis 11.43 9.73 125 97497 73126 90457699
Incorrect product administration duration 11.30 9.73 46 97576 19276 90511549
Iron deficiency anaemia 11.29 9.73 53 97569 23609 90507216
Hypervolaemia 11.25 9.73 67 97555 32690 90498135
Anion gap increased 11.17 9.73 13 97609 2257 90528568
Blood urea decreased 11 9.73 14 97608 2664 90528161
Ileus 10.98 9.73 41 97581 16505 90514320
Fibrinolysis 10.94 9.73 3 97619 24 90530801
Obstruction 10.90 9.73 17 97605 3904 90526921
Pancytopenia 10.84 9.73 186 97436 120077 90410748
Hiatus hernia 10.81 9.73 55 97567 25306 90505519
Dysgeusia 10.79 9.73 95 97527 52465 90478360
Protein deficiency 10.79 9.73 6 97616 356 90530469
Diarrhoea 10.77 9.73 1162 96460 938028 89592797
Pneumonitis 10.77 9.73 83 97539 44087 90486738
Compression fracture 10.77 9.73 27 97595 8762 90522063
Chronic respiratory failure 10.74 9.73 14 97608 2727 90528098
Right ventricular dysfunction 10.74 9.73 13 97609 2351 90528474
Dyspnoea 10.67 9.73 1094 96528 879861 89650964
Liver function test increased 10.66 9.73 51 97571 84804 90446021
Mobility decreased 10.64 9.73 198 97424 250536 90280289
Drug interaction 10.62 9.73 222 97400 276231 90254594
Respiratory syncytial virus infection 10.61 9.73 30 97592 10450 90520375
Sleep disorder due to a general medical condition 10.61 9.73 20 97602 44718 90486107
Spinal cord compression 10.59 9.73 19 97603 4892 90525933
Anxiety 10.58 9.73 421 97201 309351 90221474
Acidosis 10.58 9.73 34 97588 12702 90518123
Aortic stenosis 10.58 9.73 22 97600 6314 90524511
Normal newborn 10.57 9.73 6 97616 23356 90507469
Abdominal abscess 10.55 9.73 20 97602 5367 90525458
Atrial enlargement 10.51 9.73 6 97616 375 90530450
Parainfluenzae virus infection 10.50 9.73 14 97608 2789 90528036
Cardiac arrest 10.46 9.73 165 97457 104770 90426055
Enterobacter bacteraemia 10.46 9.73 8 97614 818 90530007
Spinal compression fracture 10.40 9.73 38 97584 15140 90515685
Pollakiuria 10.39 9.73 66 97556 32939 90497886
Product dose omission issue 10.33 9.73 398 97224 291289 90239536
Economic problem 10.22 9.73 15 97607 3266 90527559
Renal impairment 10.19 9.73 69 97553 105352 90425473
Subdural haematoma 10.03 9.73 40 97582 16605 90514220
Unmasking of previously unidentified disease 9.98 9.73 10 97612 1466 90529359
Urine flow decreased 9.98 9.73 6 97616 413 90530412
Headache 9.97 9.73 1068 96554 861678 89669147
Troponin I increased 9.94 9.73 13 97609 2542 90528283
Cholecystitis chronic 9.83 9.73 28 97594 9798 90521027
Hallucination, visual 9.79 9.73 50 97572 23042 90507783
Blister infected 9.75 9.73 8 97614 905 90529920

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 235.39 10.27 776 72261 184927 42363371
Appendicolith 206.97 10.27 177 72860 13279 42535019
Constipation 200.05 10.27 672 72365 161619 42386679
Appendicitis 170.24 10.27 193 72844 20420 42527878
Drug ineffective 160.77 10.27 550 72487 629647 41918651
Toxicity to various agents 151.06 10.27 104 72933 229032 42319266
Abdominal distension 140.55 10.27 351 72686 71384 42476914
Blood phosphorus increased 127.51 10.27 131 72906 12394 42535904
Drug interaction 116.84 10.27 173 72864 266826 42281472
Infective pulmonary exacerbation of cystic fibrosis 112.46 10.27 99 72938 7719 42540579
Hyperphosphataemia 107.77 10.27 122 72915 12882 42535416
Stress 105.82 10.27 234 72803 43978 42504320
Abdominal pain 99.67 10.27 612 72425 189859 42358439
Aplastic anaemia 98.94 10.27 114 72923 12270 42536028
Hyponatraemia 98.44 10.27 389 72648 101073 42447225
Ventricular fibrillation 97.82 10.27 181 72856 29942 42518356
Sleep disorder therapy 96.57 10.27 86 72951 6808 42541490
Myasthenia gravis 95.86 10.27 128 72909 16009 42532289
Ascites 93.33 10.27 260 72777 56418 42491880
Completed suicide 93.22 10.27 25 73012 96440 42451858
Cardiogenic shock 90.26 10.27 193 72844 35447 42512851
Analgesic therapy 88.65 10.27 80 72957 6444 42541854
Sepsis 82.33 10.27 604 72433 198730 42349568
Neuralgia 81.88 10.27 153 72884 25494 42522804
Drug therapy 72.79 10.27 71 72966 6309 42541989
Hypophosphataemia 70.70 10.27 128 72909 20817 42527481
Urinary tract infection 69.95 10.27 346 72691 98938 42449360
Iron deficiency 67.64 10.27 89 72948 10972 42537326
Vomiting 66.69 10.27 774 72263 288949 42259349
Blood uric acid increased 65.69 10.27 105 72932 15442 42532856
Bacterial infection 63.83 10.27 145 72892 27734 42520564
Incorrect route of product administration 60.82 10.27 131 72906 24174 42524124
Interstitial lung disease 59.53 10.27 30 73007 78432 42469866
Drug abuse 57.24 10.27 57 72980 104714 42443584
Therapeutic product effect incomplete 54 10.27 27 73010 70912 42477386
Antacid therapy 52.89 10.27 52 72985 4665 42543633
Anticoagulant therapy 52.74 10.27 51 72986 4484 42543814
Brain scan abnormal 51.58 10.27 30 73007 1209 42547089
Cerebral artery thrombosis 51.35 10.27 30 73007 1219 42547079
Intentional overdose 50.33 10.27 13 73024 51443 42496855
Dry mouth 47.97 10.27 164 72873 39715 42508583
Aspiration 46.59 10.27 98 72939 17788 42530510
Renal impairment 46.58 10.27 73 72964 110155 42438143
Ocular procedural complication 46.04 10.27 12 73025 44 42548254
Activated partial thromboplastin time prolonged 46.00 10.27 91 72946 15812 42532486
Treatment failure 45.94 10.27 25 73012 62599 42485699
Blood cholesterol increased 44.31 10.27 123 72914 26618 42521680
Clostridium test positive 42.83 10.27 50 72987 5455 42542843
Plasma cell myeloma 42.58 10.27 178 72859 47400 42500898
Victim of child abuse 42.25 10.27 26 73011 1163 42547135
Drug resistance 41.39 10.27 5 73032 34243 42514055
Cerebral hypoperfusion 40.13 10.27 24 73013 1019 42547279
Suicide attempt 39.11 10.27 15 73022 46085 42502213
Thrombosis 38.84 10.27 225 72812 68286 42480012
Rheumatoid arthritis 37.37 10.27 13 73024 42427 42505871
Fall 36.75 10.27 585 72452 233935 42314363
Swelling 36.32 10.27 188 72849 54697 42493601
Dehydration 36.28 10.27 387 72650 141380 42406918
Psoriasis 36.24 10.27 19 73018 48585 42499713
Bronchopulmonary aspergillosis allergic 36.17 10.27 42 72995 4556 42543742
Hospice care 35.28 10.27 57 72980 8456 42539842
Blood calcium increased 34.22 10.27 56 72981 8398 42539900
Somnolence 34.17 10.27 381 72656 140724 42407574
Nausea 32.90 10.27 901 72136 395898 42152400
Ulcer 31.68 10.27 80 72957 16361 42531937
Foetal exposure during pregnancy 30.40 10.27 22 73015 47289 42501009
Myocardial infarction 30.14 10.27 110 72927 123899 42424399
Troponin increased 29.94 10.27 86 72951 18976 42529322
Hyperlipidaemia 29.94 10.27 93 72944 21423 42526875
Binocular eye movement disorder 29.34 10.27 13 73024 291 42548007
Psoriatic arthropathy 29.32 10.27 4 73033 24963 42523335
Bacteraemia 29.25 10.27 102 72935 24938 42523360
Areflexia 29.13 10.27 34 73003 3709 42544589
Cytokine release syndrome 29.10 10.27 152 72885 44375 42503923
Failure to thrive 28.57 10.27 55 72982 9367 42538931
Rhabdomyolysis 28.14 10.27 57 72980 77962 42470336
Aortic stenosis 27.69 10.27 52 72985 8693 42539605
End stage renal disease 27.27 10.27 76 72961 16482 42531816
Renal failure 26.72 10.27 141 72896 143585 42404713
Congenital hiatus hernia 26.49 10.27 42 72995 6132 42542166
Micturition urgency 26.25 10.27 61 72976 11837 42536461
Hepatic function abnormal 25.98 10.27 30 73007 51537 42496761
Hypophagia 25.81 10.27 103 72934 26853 42521445
Myelosuppression 25.76 10.27 19 73018 40442 42507856
Off label use 25.70 10.27 867 72170 637468 41910830
Child abuse 25.48 10.27 17 73020 875 42547423
Contraindicated product administered 25.46 10.27 6 73031 25266 42523032
Small intestinal obstruction 24.91 10.27 75 72962 16986 42531312
Rhinovirus infection 24.66 10.27 42 72995 6506 42541792
Overdose 24.52 10.27 95 72942 105169 42443129
Complication associated with device 24.05 10.27 42 72995 6639 42541659
Coma 24.03 10.27 34 73003 53520 42494778
Multiple organ dysfunction syndrome 23.92 10.27 263 72774 96772 42451526
Shunt malfunction 23.90 10.27 11 73026 270 42548028
Respiratory distress 23.47 10.27 137 72900 41683 42506615
Gastric hypomotility 23.34 10.27 10 73027 206 42548092
Oesophageal injury 23.20 10.27 10 73027 209 42548089
Pneumonia aspiration 23.08 10.27 156 72881 49922 42498376
Sleep disorder 22.88 10.27 151 72886 47944 42500354
Gout 22.82 10.27 102 72935 27953 42520345
C-reactive protein increased 22.44 10.27 47 72990 63513 42484785
Muscle spasticity 22.14 10.27 41 72996 6781 42541517
Chronic obstructive pulmonary disease 21.97 10.27 184 72853 62930 42485368
Cystic fibrosis 21.83 10.27 22 73015 2033 42546265
Enterococcus test positive 21.60 10.27 20 73017 1665 42546633
Cardiac failure 21.47 10.27 102 72935 106754 42441544
Decubitus ulcer 21.26 10.27 52 72985 10425 42537873
Total lung capacity decreased 20.71 10.27 28 73009 3542 42544756
Injection related reaction 20.70 10.27 13 73024 603 42547695
Deep vein thrombosis 20.56 10.27 212 72825 76745 42471553
Mental status changes 20.50 10.27 133 72904 41982 42506316
Epidural lipomatosis 20.47 10.27 20 73017 1780 42546518
Drug eruption 20.43 10.27 7 73030 23068 42525230
Hip fracture 20.40 10.27 60 72977 13412 42534886
Cerebellar stroke 20.30 10.27 13 73024 624 42547674
Atelectasis 20.18 10.27 76 72961 19285 42529013
Pulmonary embolism 20.08 10.27 302 72735 119310 42428988
Blood test abnormal 20.05 10.27 58 72979 12848 42535450
Growth hormone-producing pituitary tumour 19.81 10.27 8 73029 141 42548157
Platelet transfusion 19.60 10.27 19 73018 1675 42546623
Hepatocellular injury 19.59 10.27 8 73029 23670 42524628
General physical health deterioration 19.57 10.27 366 72671 150880 42397418
Pneumonia 19.55 10.27 897 72140 421252 42127046
Faecaloma 19.50 10.27 37 73000 6233 42542065
Blood creatine phosphokinase increased 19.48 10.27 33 73004 48305 42499993
Bacteroides infection 19.30 10.27 23 73014 2564 42545734
Pseudomonal bacteraemia 19.04 10.27 22 73015 2374 42545924
Arthralgia 18.94 10.27 243 72794 204995 42343303
Pruritus 18.74 10.27 220 72817 188551 42359747
Pleuritic pain 18.69 10.27 39 72998 7038 42541260
Injection site pain 18.56 10.27 45 72992 57753 42490545
Acute respiratory failure 18.48 10.27 122 72915 38736 42509562
Suicidal ideation 18.40 10.27 34 73003 48127 42500171
Orthostatic hypertension 18.31 10.27 11 73026 471 42547827
Upper respiratory tract infection 17.46 10.27 128 72909 42045 42506253
Drug ineffective for unapproved indication 17.27 10.27 33 73004 46130 42502168
Cytomegalovirus infection 17.15 10.27 18 73019 32288 42516010
Malnutrition 16.78 10.27 59 72978 14483 42533815
Intestinal pseudo-obstruction 16.75 10.27 20 73017 2235 42546063
Viral diarrhoea 16.57 10.27 9 73028 317 42547981
Circulatory collapse 16.52 10.27 10 73027 23626 42524672
Frustration tolerance decreased 16.43 10.27 24 73013 3262 42545036
Lung opacity 16.40 10.27 33 73004 5804 42542494
Intentional product misuse 16.29 10.27 170 72867 61730 42486568
Foetal disorder 16.19 10.27 14 73023 1065 42547233
Dysphemia 16.02 10.27 18 73019 1884 42546414
Implant site erosion 15.87 10.27 6 73031 88 42548210
Malaise 15.80 10.27 262 72775 211894 42336404
Dysphagia 15.64 10.27 192 72845 72527 42475771
Urinary tract infection pseudomonal 15.63 10.27 15 73022 1306 42546992
Drug-induced liver injury 15.54 10.27 26 73011 38247 42510051
Pneumonia lipoid 15.17 10.27 6 73031 100 42548198
Ileus 15.13 10.27 69 72968 19070 42529228
Diabetes mellitus 14.87 10.27 163 72874 59924 42488374
Cerebral infarction 14.78 10.27 19 73018 31150 42517148
Leukopenia 14.63 10.27 72 72965 74674 42473624
Cervical vertebral fracture 14.42 10.27 19 73018 2344 42545954
Juvenile idiopathic arthritis 14.26 10.27 20 73017 2619 42545679
Hallucination 14.23 10.27 156 72881 57351 42490947
Pulmonary alveolar haemorrhage 14 10.27 4 73033 14812 42533486
Blood pressure decreased 13.99 10.27 52 72985 58280 42490018
Joint injury 13.99 10.27 56 72981 14620 42533678
Neutropenia neonatal 13.93 10.27 12 73025 908 42547390
Asthenia 13.92 10.27 601 72436 280192 42268106
Anaphylactic shock 13.77 10.27 12 73025 23505 42524793
Facial paralysis 13.67 10.27 50 72987 12513 42535785
Blood calcium decreased 13.63 10.27 46 72991 11062 42537236
Liver injury 13.53 10.27 8 73029 19140 42529158
Anaemia 13.47 10.27 598 72439 279680 42268618
Epilepsy 13.43 10.27 15 73022 26156 42522142
Pneumocystis jirovecii pneumonia 13.40 10.27 14 73023 25167 42523131
Hospitalisation 13.38 10.27 190 72847 74140 42474158
Therapy partial responder 13.27 10.27 9 73028 20012 42528286
Perirectal abscess 13.16 10.27 16 73021 1822 42546476
Therapeutic product effect decreased 12.95 10.27 30 73007 39120 42509178
Drooling 12.92 10.27 25 73012 4274 42544024
Sports injury 12.90 10.27 6 73031 151 42548147
Hypersensitivity 12.89 10.27 72 72965 72298 42476000
Back pain 12.86 10.27 326 72711 141450 42406848
Urinary incontinence 12.82 10.27 72 72965 21596 42526702
Haematochezia 12.80 10.27 54 72983 58382 42489916
Burkholderia test positive 12.57 10.27 12 73025 1038 42547260
Proteus test positive 12.53 10.27 7 73030 261 42548037
Bronchopulmonary aspergillosis 12.53 10.27 9 73028 19420 42528878
Lactic acidosis 12.46 10.27 38 72999 45223 42503075
Transfusion 12.43 10.27 43 72994 10471 42537827
Hypoxia 12.41 10.27 178 72859 69608 42478690
Otitis media acute 12.38 10.27 10 73027 692 42547606
Immune effector cell-associated neurotoxicity syndrome 12.34 10.27 40 72997 9421 42538877
Spinal cord compression 12.01 10.27 24 73013 4200 42544098
Volvulus 12 10.27 16 73021 1997 42546301
Gastrostomy tube site complication 11.94 10.27 5 73032 97 42548201
Angina pectoris 11.89 10.27 24 73013 32872 42515426
Seizure 11.76 10.27 280 72757 120281 42428017
Confusional state 11.75 10.27 373 72664 167224 42381074
Acute kidney injury 11.60 10.27 513 72524 366824 42181474
Myalgia 11.56 10.27 107 72930 95973 42452325
Breath sounds abnormal 11.41 10.27 46 72991 12047 42536251
Graft versus host disease 11.31 10.27 4 73033 12921 42535377
Speech disorder 11.27 10.27 87 72950 29034 42519264
Vasculitis 11.24 10.27 9 73028 18385 42529913
Accidental exposure to product 11.24 10.27 11 73026 20382 42527916
Dizziness postural 11.13 10.27 34 73003 7761 42540537
Drug reaction with eosinophilia and systemic symptoms 11.11 10.27 36 73001 42039 42506259
Fatigue 11.07 10.27 878 72159 434763 42113535
Blood growth hormone increased 10.99 10.27 9 73028 635 42547663
Intentional product use issue 10.95 10.27 75 72962 71758 42476540
Chest discomfort 10.94 10.27 64 72973 63552 42484746
Bladder cancer 10.85 10.27 8 73029 17039 42531259
Nodule 10.76 10.27 4 73033 12530 42535768
Cytomegalovirus infection reactivation 10.60 10.27 3 73034 11175 42537123
Prostate cancer 10.57 10.27 40 72997 44603 42503695
Metabolic encephalopathy 10.54 10.27 26 73011 5239 42543059
Pleural effusion 10.51 10.27 229 72808 96937 42451361
Injection site reaction 10.51 10.27 7 73030 15714 42532584
Palpitations 10.49 10.27 48 72989 50749 42497549
Crowned dens syndrome 10.45 10.27 3 73034 17 42548281
Hypoglycaemia 10.41 10.27 60 72977 59794 42488504
Incorrect dose administered 10.38 10.27 51 72986 52923 42495375

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 720.94 9.83 1377 139376 315390 110133156
Constipation 608.46 9.83 1380 139373 356406 110092140
Synovitis 323.05 9.83 5 140748 274087 110174459
Infective pulmonary exacerbation of cystic fibrosis 280.05 9.83 195 140558 14576 110433970
Appendicolith 269.82 9.83 188 140565 14067 110434479
Hand deformity 257.41 9.83 4 140749 218502 110230044
Pemphigus 248.35 9.83 5 140748 214565 110233981
Aplastic anaemia 246.56 9.83 222 140531 24086 110424460
Contraindicated product administered 241.10 9.83 20 140733 248247 110200299
Rheumatoid arthritis 238.44 9.83 46 140707 299567 110148979
Abdominal pain 230.59 9.83 1272 139481 511717 109936829
Systemic lupus erythematosus 222.66 9.83 30 140723 254308 110194238
Glossodynia 209.84 9.83 20 140733 221984 110226562
Chronic sinusitis 206.39 9.83 204 140549 24880 110423666
Duodenal ulcer perforation 206.20 9.83 4 140749 177696 110270850
Maternal exposure during pregnancy 205.21 9.83 38 140715 254845 110193701
Treatment failure 201.60 9.83 52 140701 277182 110171364
Appendicitis 200.66 9.83 213 140540 28251 110420295
Joint swelling 198.98 9.83 163 140590 442682 110005864
Drug ineffective 198.54 9.83 1132 139621 1519408 108929138
Sepsis 195.39 9.83 880 139873 326466 110122080
Macular degeneration 194.85 9.83 185 140568 21474 110427072
Pericarditis 186.74 9.83 28 140725 219086 110229460
Arthropathy 183.82 9.83 68 140685 287454 110161092
Psoriatic arthropathy 182.62 9.83 19 140734 196742 110251804
Hyponatraemia 175.10 9.83 642 140111 217011 110231535
Helicobacter infection 170.26 9.83 17 140736 181860 110266686
Folliculitis 166.99 9.83 12 140741 167641 110280905
Vaginal flatulence 166.62 9.83 132 140621 12012 110436534
Therapeutic product effect decreased 166.20 9.83 52 140701 244264 110204282
Completed suicide 164.14 9.83 52 140701 242329 110206217
Blood phosphorus increased 163.29 9.83 148 140605 16192 110432354
Wound 162.90 9.83 48 140705 234389 110214157
Proctitis 158.81 9.83 148 140605 16779 110431767
Abdominal distension 158.47 9.83 537 140216 174566 110273980
C-reactive protein abnormal 150.14 9.83 3 140750 129692 110318854
Female genital tract fistula 148.41 9.83 141 140612 16378 110432168
Hyperphosphataemia 147.51 9.83 140 140613 16241 110432305
Vaginal discharge 144.29 9.83 144 140609 17764 110430782
Urinary tract infection 141.66 9.83 802 139951 325480 110123066
Paraesthesia oral 134.39 9.83 189 140564 33482 110415064
Radiculopathy 133.30 9.83 143 140610 19193 110429353
Dehydration 132.01 9.83 703 140050 278808 110169738
Liver injury 130.99 9.83 18 140735 150395 110298151
Blood calcium decreased 129.62 9.83 192 140561 35653 110412893
Analgesic therapy 128.43 9.83 92 140661 7192 110441354
Procedural pain 127.89 9.83 190 140563 35375 110413171
Sleep disorder therapy 126.33 9.83 92 140661 7379 110441167
Ascites 126.29 9.83 329 140424 92479 110356067
Ventricular fibrillation 125.24 9.83 204 140549 41109 110407437
Alopecia 122.76 9.83 171 140582 364582 110083964
Impaired healing 121.59 9.83 49 140704 196668 110251878
Irritable bowel syndrome 120.88 9.83 30 140723 164185 110284361
Exposure during pregnancy 120.54 9.83 32 140721 167392 110281154
Fibromyalgia 116.89 9.83 36 140717 170873 110277673
Sleep disorder due to general medical condition, insomnia type 116.46 9.83 4 140749 105639 110342907
Arthralgia 116.07 9.83 554 140199 779078 109669468
Inflammation 114.84 9.83 51 140702 193187 110255359
Creatinine renal clearance decreased 114.31 9.83 140 140613 21675 110426871
Hepatic enzyme increased 109.41 9.83 149 140604 320743 110127803
Drug therapy 108.15 9.83 83 140670 7208 110441338
Colitis 108.13 9.83 331 140422 101992 110346554
Myasthenia gravis 107.82 9.83 135 140618 21376 110427170
Sedation complication 104.97 9.83 128 140625 19727 110428819
Blister 102.88 9.83 83 140670 227293 110221253
Facet joint syndrome 102.27 9.83 5 140748 96823 110351723
Type 2 diabetes mellitus 100.35 9.83 50 140703 177182 110271364
Anaemia 99.89 9.83 1100 139653 545986 109902560
Cardiogenic shock 99.15 9.83 223 140530 57115 110391431
Bursitis 99.05 9.83 22 140731 129896 110318650
Ill-defined disorder 98.69 9.83 38 140715 156815 110291731
Fall 94.49 9.83 1178 139575 602304 109846242
Hypophosphataemia 92.75 9.83 158 140595 33024 110415522
Lip dry 91.98 9.83 10 140743 100073 110348473
Mental status changes 90.69 9.83 257 140496 75865 110372681
Pulmonary embolism 90.26 9.83 523 140230 213951 110234595
Joint range of motion decreased 90.16 9.83 22 140731 121810 110326736
Blood uric acid increased 89.13 9.83 123 140630 21406 110427140
Clostridium test positive 88.51 9.83 88 140665 10805 110437741
Nasopharyngitis 88.09 9.83 236 140517 394125 110054421
Anticoagulant therapy 86.10 9.83 64 140689 5297 110443249
Antacid therapy 84.81 9.83 64 140689 5420 110443126
Plasma cell myeloma 84.48 9.83 222 140531 62714 110385832
Discomfort 83.43 9.83 90 140663 214617 110233929
Lower respiratory tract infection 82.73 9.83 113 140640 242993 110205553
Nausea 82.07 9.83 2104 138649 1233586 109214960
Peripheral venous disease 81.00 9.83 7 140746 84110 110364436
Acute respiratory failure 80.01 9.83 244 140509 75016 110373530
Intentional overdose 78.67 9.83 35 140718 132466 110316080
Cytokine release syndrome 78.58 9.83 232 140521 70074 110378472
Urticaria 78.06 9.83 182 140571 318675 110129871
Drug interaction 77.53 9.83 350 140403 499833 109948713
Iron deficiency 77.15 9.83 106 140647 18370 110430176
Failure to thrive 75.84 9.83 90 140663 13484 110435062
C-reactive protein increased 75.46 9.83 100 140653 217819 110230727
Stress 74.17 9.83 298 140455 105050 110343496
Oral candidiasis 73.97 9.83 171 140582 44589 110403957
Bacterial infection 70.79 9.83 171 140582 45865 110402681
Death 70.50 9.83 1265 139488 697604 109750942
Respiratory distress 68.33 9.83 218 140535 68656 110379890
Drug hypersensitivity 67.83 9.83 322 140431 453768 109994778
Toxicity to various agents 67.07 9.83 349 140404 480206 109968340
Hospice care 66.90 9.83 81 140672 12392 110436154
Intentional product use issue 66.88 9.83 134 140619 247772 110200774
Grip strength decreased 66.57 9.83 11 140742 80163 110368383
Orthostatic hypotension 66.00 9.83 210 140543 66039 110382507
Activated partial thromboplastin time prolonged 65.83 9.83 109 140644 22259 110426287
Bacteraemia 65.76 9.83 158 140595 42232 110406314
Small intestinal obstruction 65.72 9.83 134 140619 32079 110416467
Hypersensitivity 65.43 9.83 278 140475 403720 110044826
Infection 64.51 9.83 240 140513 361960 110086586
Neuralgia 64.04 9.83 170 140583 48308 110400238
Seizure 62.13 9.83 488 140265 220697 110227849
Deep vein thrombosis 62.03 9.83 346 140407 139541 110309005
Abdominal discomfort 61.96 9.83 274 140479 393584 110054962
Faecaloma 61.45 9.83 85 140668 14823 110433723
Chronic obstructive pulmonary disease 60.96 9.83 288 140465 108870 110339676
Psoriasis 59.77 9.83 54 140699 139939 110308607
Weight increased 59.54 9.83 303 140450 419341 110029205
Autoimmune disorder 59.03 9.83 7 140746 65476 110383070
Troponin increased 58.59 9.83 122 140631 29644 110418902
Osteoarthritis 58.07 9.83 89 140664 182534 110266012
Thrombosis 57.29 9.83 282 140471 108380 110340166
Rash 56.38 9.83 722 140031 820242 109628304
Vomiting 56.35 9.83 1537 139216 909138 109539408
Hypotension 55.55 9.83 956 139797 522893 109925653
Creatinine renal clearance increased 55.38 9.83 42 140711 3583 110444963
Hypophagia 55.36 9.83 170 140583 52456 110396090
Pruritus 53.85 9.83 477 140276 581083 109867463
Brain scan abnormal 53.25 9.83 30 140723 1541 110447005
Hyperlipidaemia 52.82 9.83 131 140622 35717 110412829
Liver disorder 52.65 9.83 62 140691 142181 110306365
Cerebral artery thrombosis 51.58 9.83 30 140723 1638 110446908
Pleural effusion 50.96 9.83 394 140359 177315 110271231
Transfusion 50.83 9.83 105 140648 25367 110423179
Hypoxia 50.71 9.83 310 140443 129205 110319341
Myelosuppression 49.90 9.83 29 140724 94311 110354235
End stage renal disease 49.47 9.83 94 140659 21379 110427167
Renal function test abnormal 49.46 9.83 59 140694 8887 110439659
Infusion related reaction 49.21 9.83 284 140469 380878 110067668
Interstitial lung disease 49.18 9.83 63 140690 139271 110309275
Wound infection 49.14 9.83 31 140722 96434 110352112
Victim of child abuse 49.01 9.83 26 140727 1185 110447361
Intestinal obstruction 48.77 9.83 164 140589 53063 110395483
Aspiration 48.65 9.83 115 140638 30418 110418128
Injury 48.51 9.83 95 140658 177170 110271376
Upper gastrointestinal haemorrhage 48.27 9.83 157 140596 49939 110398607
Malnutrition 48.17 9.83 107 140646 27172 110421374
Red blood cell sedimentation rate increased 47.56 9.83 20 140733 78282 110370264
Aortic stenosis 47.28 9.83 70 140683 12989 110435557
Rhinovirus infection 46.78 9.83 66 140687 11723 110436823
Condition aggravated 46.53 9.83 657 140096 734179 109714367
Atelectasis 45.74 9.83 126 140627 36586 110411960
Frequent bowel movements 45.58 9.83 196 140557 71194 110377352
Musculoskeletal stiffness 45.00 9.83 193 140560 279629 110168917
Blepharospasm 44.50 9.83 8 140745 54843 110393703
Musculoskeletal pain 44.33 9.83 105 140648 182918 110265628
Bone erosion 44.26 9.83 4 140749 46367 110402179
Sedation 43.48 9.83 190 140563 69493 110379053
Balance disorder 43.13 9.83 275 140478 116285 110332261
Swelling 42.44 9.83 267 140486 350774 110097772
Peripheral swelling 42.10 9.83 321 140432 403713 110044833
Drug resistance 42.06 9.83 10 140743 56364 110392182
Cognitive disorder 41.86 9.83 221 140532 87290 110361256
Blood calcium increased 41.59 9.83 79 140674 17961 110430585
Hospitalisation 41.45 9.83 317 140436 142176 110306370
Obesity 41.32 9.83 50 140703 113301 110335245
Injection site reaction 40.91 9.83 32 140721 89038 110359508
Therapy non-responder 40.75 9.83 87 140666 157220 110291326
Paraesthesia 40.72 9.83 197 140556 276324 110172222
Dysphonia 40.70 9.83 198 140555 75731 110372815
Lethargy 40.51 9.83 230 140523 93346 110355200
Drug intolerance 40.48 9.83 327 140426 406185 110042361
Sinusitis 39.94 9.83 218 140535 296470 110152076
Somnolence 39.53 9.83 564 140189 296885 110151661
Epilepsy 38.92 9.83 42 140711 100167 110348379
Pneumonia aspiration 38.75 9.83 205 140548 81028 110367518
Pneumonia 38.22 9.83 1419 139334 875295 109573251
Renal impairment 38.20 9.83 118 140635 188327 110260219
Wheezing 38.06 9.83 181 140572 255049 110193497
Cystic fibrosis 38.03 9.83 38 140715 4693 110443853
Rectal haemorrhage 37.93 9.83 272 140481 119561 110328985
Sciatica 37.84 9.83 37 140716 92362 110356184
Lupus-like syndrome 37.67 9.83 4 140749 40788 110407758
Congenital hiatus hernia 37.47 9.83 43 140710 6216 110442330
Gout 37.42 9.83 117 140636 36449 110412097
Weight decreased 37.28 9.83 818 139935 467239 109981307
Swollen tongue 37.22 9.83 164 140589 60198 110388348
X-ray abnormal 37.17 9.83 3 140750 38114 110410432
Respiratory failure 36.93 9.83 428 140325 214904 110233642
Onychomadesis 36.31 9.83 7 140746 45656 110402890
Decubitus ulcer 36.19 9.83 75 140678 18161 110430385
Bronchopulmonary aspergillosis allergic 36.18 9.83 49 140704 8377 110440169
Ocular procedural complication 35.42 9.83 16 140737 511 110448035
Pyrexia 35.17 9.83 1437 139316 896828 109551718
Night sweats 34.78 9.83 74 140679 133909 110314637
Dysphagia 34.74 9.83 323 140430 153277 110295269
Lower limb fracture 34.70 9.83 27 140726 75321 110373225
Pregnancy 34.47 9.83 11 140742 51056 110397490
Adjustment disorder with depressed mood 34.32 9.83 7 140746 43876 110404670
Back injury 34.21 9.83 9 140744 47390 110401156
Pulmonary fibrosis 34.12 9.83 48 140705 101994 110346552
Migraine 33.73 9.83 109 140644 171543 110277003
Prescribed overdose 33.68 9.83 37 140716 87544 110361002
Coeliac disease 33.55 9.83 7 140746 43180 110405366
Road traffic accident 33.50 9.83 53 140700 107345 110341201
Colitis ulcerative 33.39 9.83 190 140563 77173 110371373
Encephalopathy 32.99 9.83 196 140557 80859 110367687
Medication error 32.87 9.83 52 140701 105314 110343232
Stomatitis 32.42 9.83 206 140547 270036 110178510
Haematochezia 31.93 9.83 254 140499 115270 110333276
Nail disorder 31.80 9.83 17 140736 57918 110390628
Knee arthroplasty 31.55 9.83 22 140731 64926 110383620
Lung disorder 30.93 9.83 121 140632 179926 110268620
Platelet transfusion 30.86 9.83 27 140726 2819 110445727
Multiple drug therapy 30.52 9.83 44 140709 7970 110440576
Injection site pain 30.29 9.83 120 140633 177802 110270744
Child abuse 30.20 9.83 17 140736 872 110447674
Anal incontinence 30.00 9.83 78 140675 21886 110426660
Urinary retention 29.98 9.83 171 140582 69512 110379034
Asthenia 29.94 9.83 1115 139638 687884 109760662
Haemoglobin decreased 29.29 9.83 462 140291 248265 110200281
Drug-induced liver injury 28.98 9.83 69 140684 119998 110328548
White blood cell count decreased 28.90 9.83 431 140322 228959 110219587
Platelet count decreased 28.65 9.83 432 140321 230011 110218535
Suicide attempt 28.63 9.83 55 140698 103339 110345207
Hip arthroplasty 28.34 9.83 18 140735 55795 110392751
Incorrect route of product administration 28.08 9.83 158 140595 63903 110384643
Gastrointestinal motility disorder 27.79 9.83 40 140713 7236 110441310
Hip fracture 27.64 9.83 103 140650 35048 110413498
Carbon dioxide decreased 27.52 9.83 32 140721 4692 110443854
Blood potassium decreased 27.50 9.83 139 140614 53975 110394571
Gastrointestinal disorder 27.22 9.83 188 140565 241764 110206782
Impaired gastric emptying 26.82 9.83 55 140698 13220 110435326
Onychomycosis 26.54 9.83 8 140745 38523 110410023
Drug abuse 26.33 9.83 126 140627 177285 110271261
Streptococcal bacteraemia 26.15 9.83 31 140722 4638 110443908
Contusion 25.92 9.83 182 140571 233179 110215367
Ileus 25.82 9.83 92 140661 30637 110417909
Arthritis 25.47 9.83 118 140635 167468 110281078
Escherichia bacteraemia 25.30 9.83 46 140707 10118 110438428
Intestinal pseudo-obstruction 25.23 9.83 26 140727 3330 110445216
Hepatic function abnormal 25.17 9.83 47 140706 89248 110359298
Multiple organ dysfunction syndrome 24.88 9.83 299 140454 151411 110297135
Urinary incontinence 24.83 9.83 125 140628 48462 110400084
Breath sounds abnormal 24.82 9.83 80 140673 25324 110423222
Mucosal inflammation 24.74 9.83 208 140545 95933 110352613
Proctalgia 24.64 9.83 53 140700 13169 110435377
Hypercholesterolaemia 24.57 9.83 49 140704 90788 110357758
Gait inability 24.49 9.83 90 140663 136286 110312260
Exostosis 24.48 9.83 14 140739 45942 110402604
Drooling 24.04 9.83 37 140716 7102 110441444
Unresponsive to stimuli 23.90 9.83 151 140602 63639 110384907
Lymphocyte count decreased 23.66 9.83 139 140614 57104 110391442
Hypoaesthesia 23.52 9.83 271 140482 313952 110134594
Epidural lipomatosis 23.20 9.83 20 140733 2047 110446499
Joint stiffness 23.11 9.83 31 140722 67212 110381334
Back pain 23.07 9.83 627 140126 370369 110078177
Peritonitis bacterial 22.90 9.83 45 140708 10488 110438058
Gastric hypomotility 22.88 9.83 10 140743 295 110448251
Immune effector cell-associated neurotoxicity syndrome 22.82 9.83 55 140698 14727 110433819
Enterococcus test positive 22.75 9.83 23 140730 2881 110445665
Blood test abnormal 22.73 9.83 84 140669 28470 110420076
Bacteroides infection 22.65 9.83 23 140730 2896 110445650
Neurogenic bladder 22.51 9.83 30 140723 5049 110443497
Spinal cord compression 22.49 9.83 37 140716 7515 110441031
Drug tolerance decreased 22.37 9.83 4 140749 27536 110421010
Growth hormone-producing pituitary tumour 21.82 9.83 8 140745 147 110448399
Total lung capacity decreased 21.38 9.83 35 140718 7079 110441467
Tremor 21.35 9.83 369 140384 201863 110246683
Areflexia 21.29 9.83 34 140719 6735 110441811
Product odour abnormal 21.27 9.83 17 140736 1566 110446980
Osteoporosis 21.10 9.83 50 140703 87102 110361444
Shunt malfunction 21.03 9.83 10 140743 360 110448186
Diabetes mellitus 20.98 9.83 206 140547 99175 110349371
Oedema 20.83 9.83 169 140584 209807 110238739
Hallucination 20.81 9.83 209 140544 101223 110347323
Blood sodium decreased 20.58 9.83 100 140653 38219 110410327
Injection site erythema 20.51 9.83 57 140696 94119 110354427
Foot deformity 20.33 9.83 19 140734 48461 110400085
Haematocrit decreased 20.30 9.83 149 140604 65968 110382578
Drug eruption 20.27 9.83 23 140730 53636 110394910
Atrial fibrillation 20.09 9.83 407 140346 229235 110219311
Cellulitis 20.07 9.83 247 140506 125769 110322777
Depressed level of consciousness 20.06 9.83 225 140528 112053 110336493
Hepatotoxicity 20.05 9.83 31 140722 63369 110385177
Coma 19.74 9.83 80 140673 117789 110330757
Pseudomonal bacteraemia 19.66 9.83 26 140727 4345 110444201
Hepatic cirrhosis 19.59 9.83 35 140718 67591 110380955
Hyponatraemic seizure 19.50 9.83 12 140741 727 110447819
Product complaint 19.48 9.83 50 140703 13922 110434624
Oesophageal injury 19.46 9.83 9 140744 304 110448242
Blood albumin decreased 19.28 9.83 78 140675 27574 110420972
Flatulence 19.26 9.83 123 140630 52026 110396520
Aspartate aminotransferase increased 19.17 9.83 298 140455 159638 110288908
Fumbling 18.92 9.83 7 140746 132 110448414
Abortion spontaneous 18.90 9.83 10 140743 34272 110414274
Adverse reaction 18.89 9.83 7 140746 29587 110418959
Pneumonia viral 18.85 9.83 43 140710 11114 110437432
Large intestinal obstruction 18.75 9.83 24 140729 3884 110444662
Therapeutic response decreased 18.45 9.83 62 140691 96437 110352109
Myocardial infarction 18.42 9.83 156 140597 191927 110256619
Blood creatinine increased 18.34 9.83 331 140422 182558 110265988
Product administered to patient of inappropriate age 18.29 9.83 35 140718 8001 110440545
Injection site pruritus 18.27 9.83 23 140730 51235 110397311
Urinary tract infection pseudomonal 18.14 9.83 18 140735 2204 110446342
Perirectal abscess 18.06 9.83 18 140735 2216 110446330
Non-cardiac chest pain 18.00 9.83 40 140713 10158 110438388
Hypokalaemia 17.52 9.83 328 140425 182120 110266426
Thrombocytopenia 17.45 9.83 574 140179 348311 110100235
Micturition urgency 17.23 9.83 59 140694 19261 110429285
Asthma 17.15 9.83 220 140533 250071 110198475
Haemorrhoids 16.99 9.83 90 140663 35582 110412964
Labelled drug-drug interaction medication error 16.98 9.83 8 140745 29294 110419252
Leukocytosis 16.92 9.83 122 140631 53706 110394840
Foreign body sensation in eyes 16.83 9.83 21 140732 3313 110445233
Premature delivery 16.80 9.83 9 140744 30623 110417923
Oedema peripheral 16.77 9.83 542 140211 328118 110120428
Hepatocellular injury 16.75 9.83 24 140729 50618 110397928
Ulcer 16.74 9.83 103 140650 43013 110405533
Embolism 16.55 9.83 52 140701 16237 110432309
Benign prostatic hyperplasia 16.54 9.83 56 140697 18178 110430368
Malignant neoplasm progression 16.48 9.83 313 140440 174254 110274292
Sinus tachycardia 16.47 9.83 105 140648 44388 110404158
Hepatitis 16.45 9.83 59 140694 89995 110358551
Sports injury 16.32 9.83 7 140746 197 110448349
Normal newborn 16.11 9.83 4 140749 21892 110426654
Product taste abnormal 16.07 9.83 18 140735 2534 110446012
Salivary gland enlargement 16.02 9.83 9 140744 460 110448086
Rectal prolapse 16.01 9.83 18 140735 2545 110446001
Full blood count decreased 15.99 9.83 82 140671 32017 110416529
Product dose omission issue 15.99 9.83 529 140224 321253 110127293
Pleuritic pain 15.92 9.83 51 140702 16089 110432457
Blood phosphorus decreased 15.77 9.83 32 140721 7633 110440913
Chronic respiratory failure 15.71 9.83 22 140731 3881 110444665
Swelling face 15.59 9.83 183 140570 92138 110356408
Clostridium difficile colitis 15.40 9.83 102 140651 43676 110404870
Gastrostomy tube site complication 15.40 9.83 7 140746 227 110448319
Hypertension 15.24 9.83 514 140239 509570 109938976
Lower gastrointestinal haemorrhage 15.23 9.83 55 140698 18431 110430115
Laryngitis 15.14 9.83 19 140734 42392 110406154
Upper respiratory tract infection 15.10 9.83 243 140510 131085 110317461
Abdominal pain lower 15.07 9.83 90 140663 37193 110411353
Enterovirus infection 14.87 9.83 18 140735 2752 110445794
Angina pectoris 14.87 9.83 36 140717 62259 110386287
Taste disorder 14.67 9.83 39 140714 65348 110383198
Product use issue 14.66 9.83 294 140459 311401 110137145
Medical device site pain 14.64 9.83 8 140745 387 110448159
Hyponatraemic encephalopathy 14.58 9.83 8 140745 390 110448156
Red blood cell count decreased 14.58 9.83 138 140615 65785 110382761
Volvulus 14.41 9.83 20 140733 3498 110445048
Kyphosis 14.40 9.83 19 140734 3168 110445378
Facial paralysis 14.33 9.83 65 140688 24149 110424397
Rhabdomyolysis 14.31 9.83 92 140661 120309 110328237
Loss of personal independence in daily activities 14.31 9.83 122 140631 149898 110298648
Adenocarcinoma of colon 14.20 9.83 27 140726 6141 110442405
Sleep disorder due to a general medical condition 14.19 9.83 28 140725 52084 110396462
Cytomegalovirus infection reactivation 14.18 9.83 3 140750 18330 110430216
Toxic epidermal necrolysis 14.17 9.83 32 140721 56695 110391851
Pulmonary function test decreased 14.11 9.83 33 140720 8667 110439879
Adverse event 14.06 9.83 81 140672 108728 110339818
Viral diarrhoea 14.05 9.83 9 140744 585 110447961
Vasculitis 13.96 9.83 15 140738 35858 110412688
Hallucination, visual 13.77 9.83 92 140661 39513 110409033
Orthostatic hypertension 13.66 9.83 11 140742 1024 110447522
Urinary tract infection enterococcal 13.63 9.83 20 140733 3682 110444864
Neutrophil count decreased 13.61 9.83 223 140530 120718 110327828
Tuberculosis 13.56 9.83 3 140750 17771 110430775
Lung opacity 13.54 9.83 39 140714 11613 110436933
Impaired fasting glucose 13.51 9.83 9 140744 625 110447921
Noninfectious peritonitis 13.51 9.83 7 140746 304 110448242
Adverse drug reaction 13.41 9.83 79 140674 105480 110343066
Injection related reaction 13.29 9.83 13 140740 1565 110446981
Escherichia urinary tract infection 13.25 9.83 48 140705 16114 110432432
Tricuspid valve disease 13.22 9.83 8 140745 470 110448076
Mean platelet volume increased 13.11 9.83 13 140740 1591 110446955
Pneumonia lipoid 13.10 9.83 6 140747 198 110448348
Product use in unapproved indication 13.08 9.83 452 140301 446925 110001621
Device expulsion 13.08 9.83 12 140741 30879 110417667
Injection site swelling 13.01 9.83 38 140715 61752 110386794
Pseudohyponatraemia 12.99 9.83 6 140747 202 110448344
Cervical vertebral fracture 12.96 9.83 22 140731 4583 110443963
Mastication disorder 12.86 9.83 19 140734 3519 110445027
Anion gap increased 12.56 9.83 21 140732 4323 110444223
International normalised ratio increased 12.51 9.83 167 140586 86605 110361941
Dizziness postural 12.50 9.83 44 140709 14565 110433981
Overdose 12.39 9.83 216 140537 233578 110214968
Economic problem 11.98 9.83 20 140733 4111 110444435
Clostridium difficile infection 11.97 9.83 110 140643 52019 110396527
Complication associated with device 11.97 9.83 54 140699 20019 110428527
Scoliosis 11.91 9.83 31 140722 8702 110439844
Essential hypertension 11.90 9.83 29 140724 7818 110440728
Metabolic encephalopathy 11.88 9.83 36 140717 11024 110437522
Hydronephrosis 11.88 9.83 55 140698 20610 110427936
Accidental exposure to product 11.86 9.83 29 140724 49979 110398567
Pneumonia respiratory syncytial viral 11.82 9.83 16 140737 2733 110445813
Cytomegalovirus infection 11.82 9.83 33 140720 54411 110394135
Disease progression 11.81 9.83 400 140353 243634 110204912
Eye irritation 11.80 9.83 78 140675 33374 110415172
Drug reaction with eosinophilia and systemic symptoms 11.77 9.83 59 140694 82036 110366510
Oesophageal achalasia 11.71 9.83 10 140743 1011 110447535
Cardiac failure congestive 11.70 9.83 263 140490 150737 110297809
Foetal death 11.67 9.83 3 140750 16042 110432504
Hypertonia 11.63 9.83 30 140723 8376 110440170
Urinary tract infection staphylococcal 11.60 9.83 10 140743 1023 110447523
Faeces hard 11.58 9.83 20 140733 4226 110444320
Ischaemic stroke 11.55 9.83 91 140662 41172 110407374
Colitis ischaemic 11.53 9.83 49 140704 17701 110430845
Chills 11.52 9.83 321 140432 190259 110258287
Gastrointestinal haemorrhage 11.52 9.83 284 140469 165234 110283312
Agitation 11.47 9.83 205 140548 112846 110335700
Infrequent bowel movements 11.46 9.83 14 140739 2161 110446385
Otitis media acute 11.43 9.83 12 140741 1570 110446976
Poisoning deliberate 11.42 9.83 10 140743 26321 110422225
Anaphylactic shock 11.37 9.83 31 140722 51515 110397031
Dysuria 11.35 9.83 122 140631 60109 110388437
Seizure cluster 11.31 9.83 9 140744 824 110447722
Spleen atrophy 11.31 9.83 4 140749 66 110448480
Blood chloride increased 11.26 9.83 25 140728 6347 110442199
Neutrophil count abnormal 11.25 9.83 22 140731 5110 110443436
Alpha haemolytic streptococcal infection 11.24 9.83 18 140735 3575 110444971
Bandaemia 11.23 9.83 7 140746 434 110448112
Carbohydrate antigen 125 increased 11.22 9.83 15 140738 2532 110446014
Post transplant lymphoproliferative disorder 11.20 9.83 3 140750 15610 110432936
Panniculitis 11.17 9.83 3 140750 15579 110432967
Sickle cell anaemia with crisis 11.14 9.83 32 140721 9513 110439033
Behaviour disorder 10.93 9.83 32 140721 9615 110438931
Crowned dens syndrome 10.92 9.83 3 140750 20 110448526
Therapy partial responder 10.90 9.83 19 140734 37042 110411504
Pharyngeal perforation 10.79 9.83 3 140750 21 110448525
Pneumocystis jirovecii pneumonia 10.76 9.83 24 140729 42711 110405835
Parenteral nutrition 10.70 9.83 9 140744 891 110447655
Myalgia 10.68 9.83 209 140544 222172 110226374
Hypervolaemia 10.67 9.83 103 140650 49357 110399189
Suicidal ideation 10.55 9.83 73 140680 93864 110354682
Urosepsis 10.51 9.83 71 140682 30604 110417942
Delayed haemolytic transfusion reaction 10.44 9.83 3 140750 24 110448522
Nasal flaring 10.37 9.83 4 140749 85 110448461
Hyperglycaemia 10.37 9.83 159 140594 84931 110363615
Rebound effect 10.33 9.83 3 140750 14803 110433743
Listeraemia 10.33 9.83 4 140749 86 110448460
Mobility decreased 10.26 9.83 227 140526 237195 110211351
Bowel movement irregularity 10.25 9.83 27 140726 7633 110440913
Radiotherapy 10.25 9.83 11 140742 1477 110447069
Strabismus 10.23 9.83 17 140736 3482 110445064
Bacterial translocation 10.22 9.83 11 140742 1481 110447065
Bronchiolitis 10.21 9.83 22 140731 5471 110443075
Respiratory syncytial virus infection 10.21 9.83 41 140712 14443 110434103
Memory impairment 10.10 9.83 183 140570 196761 110251785
Neutropenia 10.09 9.83 578 140175 374042 110074504
Blood creatinine decreased 10.06 9.83 30 140723 9107 110439439
Pulmonary toxicity 10.05 9.83 5 140748 17741 110430805
Mental disorder 10.02 9.83 84 140669 38707 110409839
Instillation site pain 10 9.83 8 140745 738 110447808
Proteus test positive 9.98 9.83 8 140745 740 110447806
Juvenile idiopathic arthritis 9.98 9.83 23 140730 5984 110442562
Incorrect product administration duration 9.96 9.83 52 140701 20446 110428100
Crystal nephropathy 9.87 9.83 12 140741 1844 110446702

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AD15 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
ATC A06AD65 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives
FDA PE N0000009871 Stimulation Large Intestine Fluid/Electrolyte Secretion
FDA MoA N0000010288 Osmotic Activity
FDA EPC N0000175811 Osmotic Laxative
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35526 hypoglycemic agent

Related Drugs by ATC class:

A06AD Osmotically acting laxatives 13 drugs
lactitollactulosemagnesium carbonatemagnesium citratemagnesium oxidemagnesium peroxidemagnesium sulfatemannitolpentaerythritolsodium phosphatesodium sulfatesodium tartrate show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Tear film insufficiency indication 46152009
Red eye indication 75705005
Incomplete passage of stool indication 249515001
Keratoconjunctivitis sicca off-label use 302896008 DOID:12895
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Paralytic ileus contraindication 55525008 DOID:8442
Perforation of intestine contraindication 56905009 DOID:2074
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Incontinence of feces contraindication 72042002
Diabetes mellitus contraindication 73211009 DOID:9351
Appendicitis contraindication 74400008 DOID:8337
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Hyperglycemia contraindication 80394007 DOID:4195
Intestinal obstruction contraindication 81060008 DOID:8437
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Gastroparesis contraindication 235675006
Hyporeninemic hypoaldosteronism contraindication 236464008
Pyloric obstruction contraindication 244815007
Edema contraindication 267038008
Injury of eye region contraindication 282752000
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Unconscious contraindication 418107008
Severe dehydration contraindication 450316000
Predisposition to Nausea and Vomiting contraindication
Suppression of the Gag Reflex contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 11529368 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 12083179 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT SUFLAVE AZURITY N215344 June 15, 2023 RX FOR SOLUTION ORAL 12239659 June 14, 2044 GASTROINTESTINAL FLAVORED SOLUTION INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT SUFLAVE AZURITY N215344 June 15, 2023 RX FOR SOLUTION ORAL 12433914 June 14, 2044 GASTROINTESTINAL FLAVORED SOLUTION INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT SUFLAVE AZURITY N215344 June 15, 2023 RX FOR SOLUTION ORAL June 15, 2026 NEW PRODUCT

Bioactivity Summary:

None

External reference:

IDSource
4020355 VUID
N0000148185 NUI
D03370 KEGG_DRUG
4010510 VANDF
4010512 VANDF
4017885 VANDF
4018073 VANDF
4018836 VANDF
4019294 VANDF
4020325 VANDF
4020355 VANDF
4020744 VANDF
4020749 VANDF
4020755 VANDF
4020756 VANDF
4024435 VANDF
4024437 VANDF
CHEBI:46793 CHEBI
P4K PDB_CHEM_ID
CHEMBL1201478 ChEMBL_ID
CHEMBL1201479 ChEMBL_ID
C000595212 MESH_SUPPLEMENTAL_RECORD_UI
C000595213 MESH_SUPPLEMENTAL_RECORD_UI
C000595211 MESH_SUPPLEMENTAL_RECORD_UI
DB09287 DRUGBANK_ID
DB11077 DRUGBANK_ID
DB11161 DRUGBANK_ID
1310594 RXNORM
170507 MMSL
37581 MMSL
5316 MMSL
64169 MMSL
NOCODE MMSL
d05350 MMSL
002459 NDDF
002470 NDDF
006552 NDDF
007839 NDDF
009223 NDDF
009954 NDDF
010247 NDDF
010266 NDDF
356076006 SNOMEDCT_US
421083001 SNOMEDCT_US
424535007 SNOMEDCT_US
712566007 SNOMEDCT_US
712567003 SNOMEDCT_US
712568008 SNOMEDCT_US
713360008 SNOMEDCT_US
8030004 SNOMEDCT_US
C0032483 UMLSCUI
CHEMBL2108780 ChEMBL_ID
174 PUBCHEM_CID
G2M7P15E5P UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Systane Lubricant HUMAN OTC DRUG LABEL 2 0065-0429 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0431 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0454 GEL 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane Ultra HUMAN OTC DRUG LABEL 2 0065-1431 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
SystaneULTRA HUMAN OTC DRUG LABEL 2 0065-1432 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1437 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane Ultra Preservative Free HUMAN OTC DRUG LABEL 2 0065-1507 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1510 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
GenTeal Tears Gel Drops HUMAN OTC DRUG LABEL 2 0065-8067 GEL 4 mg OPHTHALMIC OTC Monograph Drug 13 sections
Good Sense Clear Lax HUMAN OTC DRUG LABEL 1 0113-0306 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
good sense clearlax HUMAN OTC DRUG LABEL 1 0113-1023 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
injoy constipation relief HUMAN OTC DRUG LABEL 1 0113-6900 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
Glitch Advanced Relief Eye Drops HUMAN OTC DRUG LABEL 2 0276-0801 SOLUTION/ DROPS 1 g OPHTHALMIC OTC Monograph Drug 14 sections
smooth lax HUMAN OTC DRUG LABEL 1 0363-0306 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
smooth lax HUMAN OTC DRUG LABEL 1 0363-0306 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
smoothlax HUMAN OTC DRUG LABEL 1 0363-1323 POWDER, FOR SOLUTION 17 g ORAL ANDA 16 sections
Walgreens Multi-Symptom Relief Eye Drops HUMAN OTC DRUG LABEL 5 0363-1462 SOLUTION/ DROPS 1 g OPHTHALMIC OTC Monograph Drug 13 sections
Walgreens Sterile Advance Relief Eye Drops HUMAN OTC DRUG LABEL 4 0363-1677 SOLUTION/ DROPS 0.01 mg OPHTHALMIC OTC monograph final 12 sections
Walgreens Eye Drops Advanced Relief 15mL HUMAN OTC DRUG LABEL 4 0363-4547 SOLUTION/ DROPS 1 g OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Lubricant Eye Drops High Performance 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4549 SOLUTION/ DROPS 0.40 g OPHTHALMIC OTC Monograph Drug 14 sections
Walgreens Lubricant Eye Drops Dry Eye 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4551 SOLUTION/ DROPS 0.40 g OPHTHALMIC OTC Monograph Drug 13 sections
Walgreens HUMAN OTC DRUG LABEL 1 0363-5260 POWDER, FOR SOLUTION 17 g ORAL ANDA 17 sections
Walgreens Lubricant HUMAN OTC DRUG LABEL 2 0363-6153 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Lubricant HUMAN OTC DRUG LABEL 2 0363-6153 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Ultra Lubricant HUMAN OTC DRUG LABEL 2 0363-6154 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Ultra Lubricant HUMAN OTC DRUG LABEL 2 0363-6154 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC Monograph Drug 12 sections
Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-6451 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC monograph final 13 sections
Walgreens Lubricant Eye Drops HUMAN OTC DRUG LABEL 2 0363-7220 SOLUTION/ DROPS 0.40 mg OPHTHALMIC OTC monograph final 11 sections
Walgreens Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-7267 SOLUTION/ DROPS 4 mg OPHTHALMIC OTC monograph final 12 sections
Eye Lubricant HUMAN OTC DRUG LABEL 2 0363-8396 LIQUID 4 mg OPHTHALMIC OTC monograph final 12 sections