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bacampicillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 280 | 50972-17-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract; RN given refers to parent cpd; structure
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.20 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.389 | Moderate | 0.69 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 31.261 | Moderate | 0.69 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 2.328 | 10^-6 cm/s | Moderate | 0.69 |
| dh-clint | Dog hepatocyte intrinsic clearance | 59.704 | uL/min/10^6 cells | Moderate | 0.69 |
| dppb | Dog plasma protein binding (% unbound) | 4.910 | % | Moderate | 0.69 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 12.710 | % | Moderate | 0.69 |
| herg | hERG pIC50 | 4.395 | pIC50 | Moderate | 0.69 |
| hh-clint | Human hepatocyte intrinsic clearance | 43.351 | uL/min/10^6 cells | Moderate | 0.69 |
| hlm-clint | Human liver microsomal intrinsic clearance | 190.108 | uL/min/mg protein | Moderate | 0.69 |
| hppb | Human plasma protein binding (% unbound) | 9.660 | % | Moderate | 0.69 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 | 43 | |||
| kinase-selectivity-class | AXL,GRK2 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 7.311 | Moderate | 0.69 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 23.550 | Moderate | 0.69 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 273.527 | Moderate | 0.69 | |
| mppb | Mouse plasma protein binding (% unbound) | 7.130 | Moderate | 0.69 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 41.495 | Moderate | 0.69 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 13.900 | % | Moderate | 0.69 |
| rat-kpuu-brain | Rat brain Kpuu | 0.027 | % | Moderate | 0.69 |
| rh-clint | Rat hepatocyte intrinsic clearance | 158.125 | uL/min/10^6 cells | Moderate | 0.69 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 37.280 | % | Moderate | 0.69 |
| rppb | Rat plasma protein binding (% unbound) | 7.170 | % | Moderate | 0.69 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 127.057 | uM | Moderate | 0.69 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 22, 1980 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01CA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:50266 | prodrug |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
Related Drugs by ATC class:
J01CA Penicillins with extended spectrum 18 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gonorrhea | indication | 15628003 | DOID:7551 |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Sinusitis | indication | 36971009 | |
| Urinary tract infectious disease | indication | 68566005 | |
| Haemophilus influenzae pneumonia | indication | 70036007 | |
| Infective otitis media | indication | 312218008 | |
| Pharyngitis | indication | 405737000 | DOID:2275 |
| Cholangitis | off-label use | 82403002 | DOID:9446 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.17 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019623 | VUID |
| N0000147716 | NUI |
| D00927 | KEGG_DRUG |
| 37661-08-8 | SECONDARY_CAS_RN |
| 18687 | RXNORM |
| C0052865 | UMLSCUI |
| CHEBI:2968 | CHEBI |
| CHEMBL1583 | ChEMBL_ID |
| CHEMBL1200965 | ChEMBL_ID |
| DB01602 | DRUGBANK_ID |
| C011674 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12292 | IUPHAR_LIGAND_ID |
| 3630 | INN_ID |
| 8GM2J22278 | UNII |
| 441397 | PUBCHEM_CID |
| 4240 | MMSL |
| d00151 | MMSL |
| 4018505 | VANDF |
| 4019623 | VANDF |
| 002709 | NDDF |
| 004839 | NDDF |
| 23176001 | SNOMEDCT_US |
| 372865005 | SNOMEDCT_US |
| 82312001 | SNOMEDCT_US |
Pharmaceutical products:
None