AI ASSISTANT

Ask DrugCentral

Explore drug properties, targets, and indications with answers grounded in DrugCentral.

Your question

Ask in your own words. Each question is answered independently.

Explore sample questions

Select a question to fill the editor, then ask it or make it your own.

DrugCentral answer

Your answer will appear here. Open linked drug cards in a new tab to explore the source details.

AI can make mistakes. Verify answers against the original sources before relying on them.

Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, 6-aminopenicillanic acid derivatives	198	69-53-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ampicillin hydrate ampicillin ampicillin sodium ampicillin trihydrate ampicillin anhydrous	Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Molecular weight: 349.41 Formula: C16H19N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 112.73 ALOGS: -2.76 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ampicillin hydrate
ampicillin
ampicillin sodium
ampicillin trihydrate
ampicillin anhydrous

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

Molecular weight: 349.41
Formula: C16H19N3O4S
CLOGP: -1.20
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 112.73
ALOGS: -2.76
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	O
6	g	P
2	g	R
6	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	50 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	88 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	166.85 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	62 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.22 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.85 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.40 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-1.642		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.371		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.366	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	1.545	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	86.160	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	71.340	%	High	1
herg	hERG pIC50	4.428	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	1.081	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	3.148	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	86.880	%	High	1
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70	39
kinase-selectivity-class	AXL,GRK2,MAP2K6	3
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	0.360		High	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.569		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	1.718		High	1
mppb	Mouse plasma protein binding (% unbound)	88.590		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	1.033		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	80	%	High	1
rat-kpuu-brain	Rat brain Kpuu	0.007	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	1.076	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	88.140	%	High	1
rppb	Rat plasma protein binding (% unbound)	80.440	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	924.698	uM	High	1

Approvals:

Date	Agency	Company	Orphan
Dec. 17, 1965	FDA	WYETH AYERST

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	934.65	17.19	316	14233	38446	90575452
Normal labour	633.90	17.19	106	14443	511	90613387
Delivery	538.80	17.19	109	14440	1684	90612214
Maternal exposure during pregnancy	524.22	17.19	444	14105	359619	90254279
Drug hypersensitivity	294.36	17.19	366	14183	463243	90150655
Type IV hypersensitivity reaction	269.96	17.19	72	14477	3854	90610044
Premature baby	254.96	17.19	109	14440	24968	90588930
Foetal exposure during pregnancy	238.70	17.19	123	14426	42852	90571046
Cross sensitivity reaction	223.29	17.19	58	14491	2799	90611099
Exposure during pregnancy	158.36	17.19	193	14356	238217	90375681
Low birth weight baby	154.86	17.19	58	14491	9409	90604489
Rash maculo-papular	116.79	17.19	76	14473	40857	90573041
Drug reaction with eosinophilia and systemic symptoms	113.77	17.19	76	14473	42682	90571216
Pathogen resistance	105.23	17.19	42	14507	8073	90605825
Amniotic cavity infection	102.62	17.19	27	14522	1369	90612529
Product use in unapproved indication	91.32	17.19	180	14369	336056	90277842
Toxic epidermal necrolysis	77.46	17.19	54	14495	32474	90581424
Monocytosis	76.79	17.19	20	14529	974	90612924
Multiple organ dysfunction syndrome	74.57	17.19	72	14477	68264	90545634
Enterocolitis haemorrhagic	70.11	17.19	21	14528	1711	90612187
Respiratory acidosis	62.30	17.19	29	14520	8090	90605808
Septic shock	62.10	17.19	72	14477	84088	90529810
Premature labour	62.10	17.19	34	14515	13342	90600556
Clostridium difficile colitis	60.48	17.19	43	14506	26663	90587235
Appetite disorder	59.05	17.19	29	14520	9104	90604794
Stillbirth	58.40	17.19	27	14522	7416	90606482
Caesarean section	56.69	17.19	36	14513	18541	90595357
Premature rupture of membranes	55.92	17.19	24	14525	5534	90608364
Exposure to SARS-CoV-2	55.06	17.19	19	14530	2433	90611465
Jarisch-Herxheimer reaction	54.99	17.19	13	14536	423	90613475
Ulcerative keratitis	52.28	17.19	20	14529	3433	90610465
Neonatal disorder	51.04	17.19	13	14536	579	90613319
Neonatal respiratory distress syndrome	50.71	17.19	19	14530	3082	90610816
Intraventricular haemorrhage	47.30	17.19	17	14532	2452	90611446
Glomerulonephritis membranoproliferative	47.08	17.19	11	14538	340	90613558
Alopecia	46.89	17.19	11	14538	495060	90118838
Patent ductus arteriosus	46.86	17.19	20	14529	4549	90609349
Sepsis neonatal	45.75	17.19	12	14537	601	90613297
Hepatic infarction	44.41	17.19	12	14537	674	90613224
Dysphoria	44.19	17.19	21	14528	6133	90607765
Umbilical erythema	43.49	17.19	8	14541	72	90613826
Thymus disorder	42.46	17.19	10	14539	320	90613578
Systemic candida	42.09	17.19	19	14530	4940	90608958
Anaphylactic reaction	41.22	17.19	60	14489	87464	90526434
Systemic lupus erythematosus	40.93	17.19	5	14544	361891	90252007
Glossodynia	40.20	17.19	3	14546	321776	90292122
SARS-CoV-2 test positive	40.15	17.19	24	14525	11104	90602794
Haemorrhagic diathesis	40.13	17.19	19	14530	5505	90608393
Stevens-Johnson syndrome	39.90	17.19	35	14514	29341	90584557
Enterococcal infection	39.87	17.19	23	14526	9968	90603930
Intraventricular haemorrhage neonatal	39.04	17.19	9	14540	262	90613636
Arthritis infective	39.00	17.19	21	14528	7971	90605927
Drug ineffective	38.55	17.19	364	14185	1383934	89229964
Candida infection	37.35	17.19	36	14513	34021	90579877
Renal tubular injury	37.31	17.19	12	14537	1237	90612661
Pseudomembranous colitis	36.62	17.19	16	14533	3852	90610046
Eye inflammation	36.56	17.19	20	14529	7831	90606067
Laryngeal stenosis	36.49	17.19	12	14537	1327	90612571
Peripheral swelling	35.66	17.19	11	14538	413095	90200803
Malaise	34.80	17.19	26	14523	585960	90027938
Long QT syndrome congenital	34.53	17.19	7	14542	109	90613789
Sepsis	33.63	17.19	83	14466	179731	90434167
Pulmonary haemorrhage	33.46	17.19	19	14530	7994	90605904
Arthralgia	33.22	17.19	46	14503	778476	89835422
Perinatal stroke	33.20	17.19	5	14544	10	90613888
Renal failure	32.91	17.19	68	14481	130939	90482959
Neonatal respiratory failure	32.44	17.19	8	14541	312	90613586
Joint swelling	31.63	17.19	21	14528	503279	90110619
Liver abscess	31.60	17.19	14	14535	3482	90610416
Klebsiella infection	31.53	17.19	20	14529	10277	90603621
Guillain-Barre syndrome	30.88	17.19	15	14534	4597	90609301
Clostridial infection	30.80	17.19	15	14534	4621	90609277
Foetal death	30.80	17.19	26	14523	20697	90593201
Periumbilical abscess	29.84	17.19	7	14542	220	90613678
Congenital clavicular agenesis	29.80	17.19	6	14543	90	90613808
Maternal drugs affecting foetus	29.29	17.19	15	14534	5140	90608758
Catheter site abscess	29.03	17.19	7	14542	248	90613650
Acute respiratory distress syndrome	28.99	17.19	29	14520	28657	90585241
Hepatic function abnormal	28.26	17.19	36	14513	46252	90567646
Tubulointerstitial nephritis	28.19	17.19	27	14522	25316	90588582
Apnoea	28.11	17.19	18	14531	9396	90604502
Pain in extremity	28.03	17.19	19	14530	450510	90163388
Hydrops foetalis	27.29	17.19	8	14541	605	90613293
Hypotonia	27.26	17.19	19	14530	11407	90602491
Culture stool positive	27.16	17.19	7	14542	327	90613571
Hydrocephalus	26.94	17.19	15	14534	6079	90607819
Nasopharyngitis	26.92	17.19	16	14533	407088	90206810
Premature separation of placenta	26.43	17.19	11	14538	2351	90611547
Skin warm	26.24	17.19	16	14533	7671	90606227
Fungaemia	25.81	17.19	12	14537	3338	90610560
Polyhydramnios	25.79	17.19	11	14538	2497	90611401
Drug eruption	25.61	17.19	30	14519	35377	90578521
Foetal heart rate decreased	24.90	17.19	6	14543	212	90613686
Abdominal discomfort	24.86	17.19	24	14525	477304	90136594
Sinusitis	24.86	17.19	12	14537	343076	90270822
Oligohydramnios	24.61	17.19	15	14534	7186	90606712
Ventricular dysfunction	24.57	17.19	12	14537	3719	90610179
Thinking abnormal	24.52	17.19	18	14531	11714	90602184
Selective eating disorder	24.46	17.19	10	14539	2043	90611855
Streptococcal infection	24.36	17.19	15	14534	7318	90606580
Maternal exposure during delivery	24.23	17.19	12	14537	3834	90610064
Death neonatal	23.95	17.19	10	14539	2155	90611743
Atelectasis neonatal	23.79	17.19	4	14545	20	90613878
Oedema	23.35	17.19	78	14471	200217	90413681
Ventricular septal defect	23.06	17.19	13	14536	5394	90608504
Preterm premature rupture of membranes	23.05	17.19	9	14540	1632	90612266
Renal colic	22.98	17.19	9	14540	1644	90612254
Symblepharon	22.75	17.19	6	14543	307	90613591
Bradycardia neonatal	22.74	17.19	8	14541	1085	90612813
Pain	22.70	17.19	83	14466	996258	89617640
Cervical incompetence	22.57	17.19	7	14542	641	90613257
Impaired healing	22.55	17.19	5	14544	234194	90379704
Thrombocytopenia neonatal	22.51	17.19	4	14545	29	90613869
Hallucination	22.46	17.19	39	14510	65920	90547978
Photophobia	22.41	17.19	22	14527	21247	90592651
Immune reconstitution inflammatory syndrome	22.41	17.19	14	14535	7005	90606893
Intentional product use issue	22.20	17.19	4	14545	216888	90397010
Disseminated intravascular coagulation	22.18	17.19	22	14527	21516	90592382
Bradypnoea	22.06	17.19	12	14537	4646	90609252
Generalised anxiety disorder	21.66	17.19	10	14539	2737	90611161
Endocarditis candida	21.27	17.19	4	14545	41	90613857
Circulatory collapse	21.25	17.19	23	14526	24881	90589017
Wound infection fungal	21.02	17.19	5	14544	167	90613731
Pancreatic pseudocyst	20.99	17.19	7	14542	808	90613090
Hypotonia neonatal	20.64	17.19	8	14541	1422	90612476
Drug intolerance	20.54	17.19	25	14524	447566	90166332
Leukocytosis	20.35	17.19	25	14524	30965	90582933
Fatigue	20.30	17.19	106	14443	1153917	89459981
Vaginal lesion	20.23	17.19	6	14543	472	90613426
Acute generalised exanthematous pustulosis	19.97	17.19	17	14532	13686	90600212
Umbilical cord around neck	19.96	17.19	5	14544	208	90613690
Idiosyncratic drug reaction	19.79	17.19	7	14542	964	90612934
Intestinal obstruction	19.76	17.19	27	14522	37104	90576794
Escherichia infection	19.73	17.19	18	14531	15877	90598021
Swelling	19.66	17.19	23	14526	419035	90194863
West Nile viral infection	19.61	17.19	6	14543	525	90613373
Oliguria	19.32	17.19	15	14534	10609	90603289
Stenotrophomonas infection	19.30	17.19	9	14540	2520	90611378
Discomfort	19.26	17.19	10	14539	274325	90339573
Necrotising enterocolitis neonatal	19.25	17.19	5	14544	241	90613657
Meningitis bacterial	19.22	17.19	8	14541	1709	90612189
Urine output decreased	19.12	17.19	16	14533	12587	90601311
Enterobacter infection	19.12	17.19	9	14540	2574	90611324
Listeriosis	19.11	17.19	8	14541	1735	90612163
Drug resistance	19.09	17.19	24	14525	30425	90583473
Product use issue	19.09	17.19	15	14534	329904	90283994
Syndactyly	18.94	17.19	6	14543	589	90613309
Neonatal infection	18.82	17.19	5	14544	263	90613635
Listeria encephalitis	18.77	17.19	5	14544	266	90613632
Treatment failure	18.64	17.19	13	14536	303915	90309983
Gastrointestinal disorder	18.55	17.19	9	14540	256678	90357220
Congenital lymphoedema	18.39	17.19	3	14546	12	90613886
Infusion related reaction	18.37	17.19	24	14525	416756	90197142
Hepatomegaly	18.34	17.19	16	14533	13310	90600588
Insomnia	18.26	17.19	16	14533	333458	90280440
Foetal heart rate deceleration abnormality	18.16	17.19	6	14543	673	90613225
Neonatal respiratory distress	18.07	17.19	6	14543	683	90613215
Atrial septal defect	18.04	17.19	13	14536	8221	90605677
Rash morbilliform	18.03	17.19	10	14539	4019	90609879
Meningitis aseptic	17.91	17.19	12	14537	6761	90607137
Meconium in amniotic fluid	17.88	17.19	5	14544	319	90613579
Neonatal cardiac failure	17.84	17.19	3	14546	15	90613883
Retained placenta or membranes	17.70	17.19	5	14544	331	90613567
Headache	17.64	17.19	75	14474	862671	89751227
Memory impairment	17.46	17.19	5	14544	197239	90416659
Funisitis	17.38	17.19	3	14546	18	90613880
Neuromuscular blockade	17.28	17.19	5	14544	361	90613537
Megacolon	17.27	17.19	8	14541	2206	90611692
Glomerulonephritis minimal lesion	17.20	17.19	5	14544	367	90613531

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature baby	215.59	16.57	110	11026	23043	42587156
Foetal exposure during pregnancy	198.39	16.57	134	11002	47177	42563022
Low birth weight baby	91.72	16.57	47	11089	9908	42600291
Sepsis neonatal	91.34	16.57	20	11116	274	42609925
Neonatal respiratory distress syndrome	81.52	16.57	34	11102	4479	42605720
Drug ineffective	80.93	16.57	351	10785	629846	41980353
Type IV hypersensitivity reaction	78.61	16.57	28	11108	2409	42607790
Vitamin K deficiency	78.57	16.57	19	11117	412	42609787
Neonatal disorder	75.85	16.57	21	11115	786	42609413
Pathogen resistance	69.39	16.57	41	11095	11409	42598790
Red blood cell hyperchromic morphology	65.58	16.57	10	11126	10	42610189
Drug resistance	63.24	16.57	60	11076	34188	42576011
Candida infection	60.46	16.57	48	11088	21562	42588637
Cerebral palsy	59.65	16.57	15	11121	384	42609815
Drug hypersensitivity	58.36	16.57	98	11038	99291	42510908
Atrial septal defect	55.02	16.57	31	11105	7888	42602311
Congenital multiplex arthrogryposis	54.75	16.57	13	11123	260	42609939
Fatigue	54.42	16.57	23	11113	435618	42174581
Listeriosis	52.37	16.57	18	11118	1393	42608806
Pulmonary haemorrhage	51.82	16.57	34	11102	11363	42598836
Intraventricular haemorrhage neonatal	50.75	16.57	13	11123	359	42609840
Bradycardia neonatal	49.27	16.57	17	11119	1331	42608868
Pleocytosis	47.63	16.57	14	11122	651	42609548
Patent ductus arteriosus	45.88	16.57	21	11115	3455	42606744
Necrotising colitis	45.86	16.57	16	11120	1295	42608904
Neonatal hypoxia	45.48	16.57	13	11123	547	42609652
Kidney duplex	44.71	16.57	12	11124	399	42609800
Intraventricular haemorrhage	43.66	16.57	21	11115	3863	42606336
Systemic candida	42.96	16.57	23	11113	5296	42604903
Conductive deafness	41.98	16.57	12	11124	505	42609694
Brain abscess	41.71	16.57	21	11115	4263	42605936
Death	40.77	16.57	38	11098	471147	42139052
Neonatal respiratory failure	40.66	16.57	11	11125	377	42609822
Meningitis candida	39.34	16.57	9	11127	152	42610047
Otitis media	38.65	16.57	19	11117	3664	42606535
Cardiac septal defect	38.58	16.57	13	11123	947	42609252
Leukocytosis	38.43	16.57	43	11093	29665	42580534
Bronchopulmonary dysplasia	37.47	16.57	12	11124	745	42609454
Drug reaction with eosinophilia and systemic symptoms	36.80	16.57	50	11086	42025	42568174
Anisocytosis	36.42	16.57	11	11125	562	42609637
Congenital cystic lung	36.11	16.57	9	11127	222	42609977
Diplegia	35.10	16.57	13	11123	1249	42608950
Endocarditis	33.88	16.57	23	11113	8129	42602070
Encephalitis brain stem	33.23	16.57	8	11128	170	42610029
Nutritional condition abnormal	32.83	16.57	10	11126	526	42609673
Meningitis aseptic	32.37	16.57	18	11118	4464	42605735
Pyrexia	32.24	16.57	194	10942	393848	42216351
Macrocytosis	29.22	16.57	11	11125	1106	42609093
Janeway lesion	29.08	16.57	5	11131	16	42610183
Infantile apnoea	29.04	16.57	11	11125	1125	42609074
Cross sensitivity reaction	28.18	16.57	12	11124	1663	42608536
Hydrops foetalis	27.69	16.57	10	11126	895	42609304
Death neonatal	27.60	16.57	8	11128	354	42609845
Nocardiosis	27.35	16.57	17	11119	5173	42605026
Quadriparesis	27.31	16.57	13	11123	2337	42607862
Opisthotonus	27.13	16.57	9	11127	625	42609574
Drug withdrawal syndrome neonatal	27.09	16.57	16	11120	4445	42605754
Respiratory distress	26.88	16.57	43	11093	41777	42568422
Fall	26.71	16.57	14	11122	234506	42375693
Congenital skin dimples	26.58	16.57	7	11129	216	42609983
Fungaemia	26.56	16.57	14	11122	3122	42607077
Factor V inhibition	26.37	16.57	7	11129	223	42609976
Enterocolitis haemorrhagic	25.87	16.57	10	11126	1081	42609118
Apnoea	25.46	16.57	19	11117	7784	42602415
Polyhydramnios	25.44	16.57	7	11129	256	42609943
Joint contracture	25.14	16.57	12	11124	2169	42608030
Respiratory failure	25.04	16.57	82	11054	128050	42482149
Septic shock	24.93	16.57	66	11070	91606	42518593
Encephalitis	24.87	16.57	20	11116	9138	42601061
Talipes	24.86	16.57	12	11124	2224	42607975
Joint dislocation	24.73	16.57	15	11121	4372	42605827
Pulmonary artery stenosis	23.97	16.57	7	11129	318	42609881
Necrotising enterocolitis neonatal	23.85	16.57	7	11129	324	42609875
Acute generalised exanthematous pustulosis	23.83	16.57	19	11117	8576	42601623
Rash maculo-papular	23.34	16.57	38	11098	37465	42572734
Condition aggravated	22.96	16.57	131	11005	260623	42349576
Dizziness	22.82	16.57	19	11117	249235	42360964
Strongyloidiasis	22.67	16.57	13	11123	3418	42606781
Tubulointerstitial nephritis	22.45	16.57	34	11102	31514	42578685
Type I hypersensitivity	22.21	16.57	11	11125	2155	42608044
Hypotonia	22.17	16.57	19	11117	9480	42600719
Exposure during pregnancy	21.81	16.57	18	11118	8530	42601669
Neonatal infection	21.62	16.57	7	11129	450	42609749
Drug ineffective for unapproved indication	21.27	16.57	41	11095	46122	42564077
Pulmonary physical examination abnormal	21.22	16.57	4	11132	24	42610175
Klebsiella infection	21.18	16.57	20	11116	11312	42598887
Pseudo-Bartter syndrome	20.95	16.57	4	11132	26	42610173
Meningitis	20.89	16.57	15	11121	5794	42604405
Fungal skin infection	20.33	16.57	12	11124	3329	42606870
Respiratory disorder neonatal	20.19	16.57	10	11126	1960	42608239
Posthaemorrhagic hydrocephalus	20.15	16.57	5	11131	121	42610078
Trichosporon infection	20.02	16.57	8	11128	944	42609255
Congenital syphilis	19.67	16.57	3	11133	3	42610196
Grey syndrome neonatal	19.67	16.57	3	11133	3	42610196
Septic pulmonary embolism	19.63	16.57	5	11131	135	42610064
Neonatal candida infection	19.51	16.57	4	11132	39	42610160
Asthenia	19.47	16.57	27	11109	280766	42329433
Haemorrhage neonatal	19.21	16.57	3	11133	4	42610195
Choriomeningitis lymphocytic	19.12	16.57	5	11131	150	42610049
Aspergillus infection	18.91	16.57	22	11114	15815	42594384
Maternal drugs affecting foetus	18.79	16.57	12	11124	3827	42606372
Sepsis	18.76	16.57	102	11034	199232	42410967
Lymphocytosis	18.74	16.57	11	11125	3020	42607179
Eosinophilia	18.68	16.57	32	11104	32867	42577332
Drug eruption	18.05	16.57	26	11110	23049	42587150
Disseminated intravascular coagulation	18.04	16.57	27	11109	24767	42585432
Hepatotoxicity	17.73	16.57	27	11109	25140	42585059
Neonatal cholestasis	17.19	16.57	4	11132	73	42610126
Dry gangrene	17.01	16.57	6	11130	501	42609698
Metabolic acidosis	16.88	16.57	40	11096	51818	42558381

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Type IV hypersensitivity reaction	367.00	15.95	101	18121	5932	110565145
Cross sensitivity reaction	234.49	15.95	70	18152	5497	110565580
Premature delivery	200.94	15.95	99	18123	30533	110540544
Drug hypersensitivity	195.64	15.95	302	17920	453788	110117289
Pathogen resistance	165.23	15.95	73	18149	17599	110553478
Drug reaction with eosinophilia and systemic symptoms	155.78	15.95	120	18102	81975	110489102
Drug ineffective	151.11	15.95	569	17653	1519971	109051106
Exposure during pregnancy	147.56	15.95	159	18063	167265	110403812
Rash maculo-papular	146.33	15.95	111	18111	74111	110496966
Maternal exposure during pregnancy	111.55	15.95	171	18051	254712	110316365
Enterocolitis haemorrhagic	93.64	15.95	29	18193	2575	110568502
Amniotic cavity infection	78.09	15.95	20	18202	887	110570190
Clostridium difficile colitis	76.52	15.95	61	18161	43717	110527360
Septic shock	76.45	15.95	111	18111	157417	110413660
Toxic epidermal necrolysis	74.40	15.95	67	18155	56660	110514417
Candida infection	67.53	15.95	59	18163	47950	110523127
Listeriosis	67.27	15.95	23	18199	2791	110568286
Monocytosis	65.20	15.95	20	18202	1720	110569357
Vitamin K deficiency	63.38	15.95	17	18205	904	110570173
Drug resistance	63.17	15.95	61	18161	56313	110514764
Multiple organ dysfunction syndrome	62.41	15.95	99	18123	151611	110419466
Anaphylactic reaction	62.05	15.95	85	18137	114215	110456862
Tubulointerstitial nephritis	61.32	15.95	59	18163	54225	110516852
Enterococcal infection	60.05	15.95	39	18183	20327	110550750
Appetite disorder	53.60	15.95	28	18194	9741	110561336
Meningitis aseptic	53.33	15.95	28	18194	9842	110561235
Premature labour	52.37	15.95	27	18195	9145	110561932
Arthritis infective	51.88	15.95	28	18194	10401	110560676
Pyrexia	51.60	15.95	287	17935	897978	109673099
Exposure to SARS-CoV-2	51.34	15.95	19	18203	2900	110568177
Caesarean section	47.09	15.95	29	18193	13788	110557289
Premature rupture of membranes	46.07	15.95	20	18202	4617	110566460
Stevens-Johnson syndrome	45.62	15.95	47	18175	46854	110524223
Ulcerative keratitis	45.54	15.95	20	18202	4746	110566331
Alopecia	45.35	15.95	4	18218	364749	110206328
Pleocytosis	44.79	15.95	15	18207	1709	110569368
Brain abscess	44.71	15.95	22	18200	6752	110564325
Klebsiella infection	44.05	15.95	32	18190	19977	110551100
Drug eruption	43.79	15.95	49	18173	53610	110517467
Leukocytosis	43.67	15.95	49	18173	53779	110517298
Photophobia	43.10	15.95	35	18187	25736	110545341
Glomerulonephritis membranoproliferative	41.55	15.95	12	18210	838	110570239
Encephalitis	41.18	15.95	30	18192	18809	110552268
Pseudomembranous colitis	39.94	15.95	20	18202	6371	110564706
Hepatic infarction	39.85	15.95	12	18210	969	110570108
Dysphoria	39.83	15.95	20	18202	6408	110564669
Haemorrhagic diathesis	39.72	15.95	21	18201	7487	110563590
Meningitis candida	39.71	15.95	9	18213	236	110570841
Hepatic function abnormal	39.11	15.95	60	18162	89235	110481842
Fatigue	37.87	15.95	91	18131	1215867	109355210
Jarisch-Herxheimer reaction	37.31	15.95	12	18210	1205	110569872
Respiratory acidosis	37.18	15.95	25	18197	13801	110557276
Malaise	36.72	15.95	34	18188	671785	109899292
Thymus disorder	36.50	15.95	10	18212	576	110570501
Encephalitis brain stem	36.46	15.95	9	18213	343	110570734
Arthropathy	36.15	15.95	3	18219	287519	110283558
Laryngeal stenosis	35.67	15.95	12	18210	1386	110569691
Endocarditis	35.53	15.95	24	18198	13347	110557730
Clostridial infection	34.40	15.95	18	18204	6284	110564793
Aspartate aminotransferase increased	34.16	15.95	79	18143	159857	110411220
Eye inflammation	33.18	15.95	20	18202	9151	110561926
Renal tubular injury	32.83	15.95	14	18208	3094	110567983
Sepsis	32.47	15.95	123	18099	327223	110243854
Nutritional condition abnormal	32.32	15.95	11	18211	1316	110569761
Fungaemia	32.13	15.95	17	18205	6069	110565008
Nocardiosis	31.49	15.95	18	18204	7468	110563609
Long QT syndrome congenital	31.48	15.95	7	18215	168	110570909
Janeway lesion	31.38	15.95	5	18217	16	110571061
Respiratory failure	31.23	15.95	92	18130	215240	110355837
Acute generalised exanthematous pustulosis	31.22	15.95	27	18195	21637	110549440
Renal failure	31.15	15.95	95	18127	226479	110344598
Meningitis	31.09	15.95	21	18201	11681	110559396
Acute respiratory distress syndrome	31.05	15.95	41	18181	53157	110517920
Pseudomonas infection	30.93	15.95	30	18192	27823	110543254
Peripheral swelling	30.82	15.95	14	18208	404020	110167057
Culture stool positive	30.62	15.95	9	18213	669	110570408
Acute kidney injury	30.57	15.95	194	18028	635236	109935841
SARS-CoV-2 test positive	30.45	15.95	24	18198	16911	110554166
Death	28.96	15.95	44	18178	698825	109872252
Oedema	28.83	15.95	88	18134	209888	110361189
Catheter site abscess	28.25	15.95	7	18215	271	110570806
Circulatory collapse	28.02	15.95	35	18187	42958	110528119
Pain in extremity	27.38	15.95	24	18198	487094	110083983
Periumbilical abscess	27.32	15.95	7	18215	311	110570766
Quadriparesis	27.29	15.95	14	18208	4693	110566384
Strongyloidiasis	26.53	15.95	14	18208	4972	110566105
Systemic lupus erythematosus	26.32	15.95	5	18217	254333	110316744
Meningitis bacterial	26.25	15.95	12	18210	3127	110567950
Type I hypersensitivity	25.90	15.95	15	18207	6378	110564699
Klebsiella test positive	25.78	15.95	11	18211	2435	110568642
Pericarditis	25.67	15.95	3	18219	219111	110351966
Renal infarct	25.35	15.95	12	18210	3383	110567694
Arthralgia	25.29	15.95	57	18165	779575	109791502
Meningitis listeria	24.88	15.95	9	18213	1288	110569789
Polyhydramnios	24.79	15.95	10	18212	1923	110569154
West Nile viral infection	24.69	15.95	9	18213	1317	110569760
Joint swelling	24.66	15.95	22	18200	442823	110128254
Erythema	24.47	15.95	104	18118	291343	110279734
Rash	24.47	15.95	224	17998	820740	109750337
Oliguria	24.38	15.95	22	18200	18635	110552442
Systemic candida	24.37	15.95	17	18205	9957	110561120
Eosinophilia	24.06	15.95	38	18184	57898	110513179
Premature baby	24.05	15.95	13	18209	4842	110566235
Skin test positive	23.91	15.95	9	18213	1440	110569637
Paraesthesia	23.68	15.95	8	18214	276513	110294564
Oligohydramnios	23.50	15.95	12	18210	3982	110567095
Premature separation of placenta	23.15	15.95	9	18213	1571	110569506
Pulmonary physical examination abnormal	23.07	15.95	4	18218	24	110571053
Sinusitis	23.06	15.95	10	18212	296678	110274399
Encephalopathy	23.05	15.95	45	18177	81010	110490067
Clostridium test positive	23.02	15.95	17	18205	10876	110560201
Dry mouth	22.78	15.95	3	18219	199945	110371132
Pancreatic pseudocyst	22.73	15.95	9	18213	1649	110569428
Pain	22.73	15.95	81	18141	954874	109616203
CNS ventriculitis	22.32	15.95	7	18215	648	110570429
Listeria encephalitis	22.14	15.95	6	18216	332	110570745
Mobility decreased	21.90	15.95	6	18216	237416	110333661
Maternal exposure during delivery	21.82	15.95	11	18211	3554	110567523
Product dose omission issue	21.79	15.95	13	18209	321769	110249308
Vaginal lesion	21.63	15.95	6	18216	362	110570715
Generalised anxiety disorder	21.30	15.95	10	18212	2769	110568308
Foetal death	21.12	15.95	19	18203	16026	110555051
Intraventricular haemorrhage neonatal	21.06	15.95	3	18219	3	110571074
Guillain-Barre syndrome	21.00	15.95	16	18206	10728	110560349
Skin warm	20.95	15.95	15	18207	9155	110561922
Bacteraemia	20.72	15.95	30	18192	42360	110528717
Alanine aminotransferase increased	20.69	15.95	72	18150	183701	110387376
Choriomeningitis lymphocytic	20.51	15.95	5	18217	181	110570896
Hepatotoxicity	20.26	15.95	37	18185	63363	110507714
Generalised tonic-clonic seizure	20.18	15.95	34	18188	54646	110516431
Preterm premature rupture of membranes	19.99	15.95	8	18214	1507	110569570
Stillbirth	19.97	15.95	11	18211	4253	110566824
Symblepharon	19.91	15.95	6	18216	486	110570591
Intentional product use issue	19.83	15.95	8	18214	247898	110323179
Linear IgA disease	19.67	15.95	11	18211	4378	110566699
Injection site pain	19.50	15.95	3	18219	177919	110393158
Pleural effusion	19.47	15.95	69	18153	177640	110393437
Cervical incompetence	19.28	15.95	6	18216	541	110570536
Angioedema	19.23	15.95	47	18175	98453	110472624
Wound infection fungal	19.18	15.95	5	18217	238	110570839
Toxicity to various agents	19.18	15.95	31	18191	480524	110090553
Cardiac valve vegetation	19.14	15.95	7	18215	1033	110570044
Anaphylactic shock	18.96	15.95	32	18190	51514	110519563
Drug ineffective for unapproved indication	18.95	15.95	48	18174	102790	110468287
Swelling	18.87	15.95	18	18204	351023	110220054
Foetal exposure during pregnancy	18.82	15.95	13	18209	7492	110563585
Tachycardia	18.34	15.95	80	18142	226565	110344512
Rash morbilliform	18.15	15.95	13	18209	7938	110563139
Thinking abnormal	18.13	15.95	17	18205	15123	110555954
Musculoskeletal pain	18.10	15.95	4	18218	183019	110388058
Liver transplant rejection	18.05	15.95	10	18212	3908	110567169
Beta haemolytic streptococcal infection	17.70	15.95	9	18213	2962	110568115
Insomnia	17.68	15.95	20	18202	360570	110210507
Tenderness	17.66	15.95	23	18199	29414	110541663
Sepsis neonatal	17.61	15.95	4	18218	106	110570971
Septic pulmonary embolism	17.53	15.95	5	18217	334	110570743
Drug intolerance	17.39	15.95	25	18197	406487	110164590
Red blood cell schistocytes present	17.26	15.95	6	18216	765	110570312
Depressed level of consciousness	17.25	15.95	49	18173	112229	110458848
Megacolon	17.17	15.95	10	18212	4295	110566782
Umbilical cord prolapse	17.16	15.95	3	18219	19	110571058
Prosthetic cardiac valve stenosis	17.16	15.95	3	18219	19	110571058
Aspergillus infection	16.92	15.95	21	18201	25595	110545482
Renal colic	16.91	15.95	9	18213	3249	110567828
Neonatal respiratory distress syndrome	16.81	15.95	5	18217	387	110570690
Chills	16.76	15.95	69	18153	190511	110380566
Factor V inhibition	16.70	15.95	5	18217	396	110570681
Neonatal disorder	16.66	15.95	3	18219	23	110571054
Muscle spasms	16.48	15.95	13	18209	278144	110292933
Migraine	16.48	15.95	4	18218	171648	110399429
Abdominal pain upper	16.43	15.95	20	18202	349091	110221986
Memory impairment	16.34	15.95	6	18216	196938	110374139
Uterine contractions abnormal	16.32	15.95	4	18218	148	110570929
Depression	16.22	15.95	17	18205	317318	110253759
Completed suicide	16.12	15.95	10	18212	242371	110328706

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal exposure during pregnancy	57.85	22.71	43	1028	15735	97147
Drug ineffective	48.37	22.71	67	1004	1566	111316
Candida infection	29.17	22.71	14	1057	58	112824
Abdominal distension	27.03	22.71	15	1056	89	112793
Pulmonary haemorrhage	25.71	22.71	24	1047	352	112530
Haematochezia	24.08	22.71	9	1062	16	112866
Intraventricular haemorrhage	24.03	22.71	15	1056	114	112768

Pharmacologic Action:

Source	Code	Description
ATC	J01CA01	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum
ATC	J01CA51	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum
ATC	J01CR01	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Combinations of penicillins, incl. beta-lactamase inhibitors
ATC	S01AA19	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
FDA CS	M0016152	Penicillins
FDA EPC	N0000175497	Penicillin-class Antibacterial
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:33281	antimicrobial agent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:36047	antibacterial drug
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:64946	anti-HIV agent

Related Drugs by ATC class:

J01CA Penicillins with extended spectrum 18 drugs

amoxicillin aspoxicillin azlocillin bacampicillin carbenicillin carindacillin epicillin hetacillin mecillinam metampicillin mezlocillin piperacillin show all 18 →

J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 4 drugs

amoxicillin piperacillin sultamicillin ticarcillin

S01AA Antibiotics 27 drugs

amikacin azidamfenicol azithromycin bacitracin benzylpenicillin cefmenoxime cefuroxime chloramphenicol chlortetracycline dibekacin dihydrostreptomycin erythromycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute otitis media	indication	3110003
Septicemia due to Escherichia coli	indication	9323009
Bacterial septicemia	indication	10001005	DOID:0040085
Gonorrhea	indication	15628003	DOID:7551
Haemophilus Influenzae Acute Otitis Media	indication	19021002
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Acute gonococcal cervicitis	indication	20943002	DOID:10615
Acute bacterial epiglottitis	indication	21060003
Staphylococcal pneumonia	indication	22754005
Streptococcal septicemia	indication	29577008
Acute epiglottitis	indication	29608009	DOID:9398
Acute gonococcal urethritis	indication	29864006
Pneumonia due to Streptococcus	indication	34020007
Shigellosis	indication	36188001
Sinusitis	indication	36971009
Streptococcal tonsillitis	indication	41582007
Gonorrhea of rectum	indication	42746002
Salmonella septicemia	indication	49786009
Pneumococcal meningitis	indication	51169003
Bacterial pneumonia	indication	53084003	DOID:874
Acute gonococcal endometritis	indication	65295003	DOID:7527
Urinary tract infectious disease	indication	68566005
Haemophilus influenzae pneumonia	indication	70036007
Infection due to Escherichia coli	indication	71057007
Rhinoscleroma	indication	72409005	DOID:11336
Staphylococcal endocarditis	indication	73028002
Acute bacterial sinusitis	indication	75498004
Pneumococcal pharyngitis	indication	76651006
Cholangitis	indication	82403002	DOID:9446
Paratyphoid fever	indication	85904008	DOID:3055
Bacterial meningitis	indication	95883001	DOID:9470
Dysentery	indication	111939009
Female genital tract infection	indication	125585007
Infectious disease of abdomen	indication	128070006
Infection due to Enterobacteriaceae	indication	128945009
Meningococcal meningitis	indication	192644005
Escherichia coli meningitis	indication	192655005
Bacterial peritonitis	indication	197171003
Pneumococcal pneumonia	indication	233607000
Proteus septicemia	indication	300986008
Proteus urinary tract infection	indication	301012009
Bacterial endocarditis	indication	301183007
Septicemia due to enterococcus	indication	310669007
Bacterial urinary infection	indication	312124009
Infective otitis media	indication	312218008
Pharyngitis	indication	405737000	DOID:2275
Infection due to Staphylococcus aureus	indication	406602003
Acute exacerbation of chronic bronchitis	indication	425748003
Sepsis due to Staphylococcus aureus	indication	448417001
Staphylococcus Acute Otitis Media	indication	703469002
Bacteroides Gynecological Infections	indication
Skin and Skin Structure Acinetobacter Infection	indication
Haemophilus Influenzae Pharyngitis	indication
Skin and Skin Structure Proteus Infection	indication
Cesarean Section Infection Prevention	indication
Streptococcus Pneumoniae Chronic Bronchitis	indication
Haemophilus Influenzae Chronic Bronchitis	indication
Skin and Skin Structure Bacteroides Fragilis Infection	indication
Vaginal Hysterectomy Infection Prevention	indication
Pneumococcal Acute Otitis Media	indication
Staphylococcus Epidermidis Skin and Skin Structure Infection	indication
Streptococcal Endocarditis	indication
Bacteroides Peritonitis	indication
E. Coli Peritonitis	indication
Gastroenteritis due to Salmonella	indication
Enterococcus Urinary Tract Infection	indication
Neonatal Group B Streptococcal Septicemia	indication
Klebsiella Pneumoniae Peritonitis	indication
Genitourinary Tract Infections	indication
Inflammatory Disease of Female Pelvic Organs	indication
Intra-Abdominal E. Coli Abscess	indication
E. Coli Gynecological Infections	indication
Infection Prevention for GI Surgery	indication
Necrotizing enterocolitis in fetus OR newborn	off-label use	2707005
Listeriosis	off-label use	4241002	DOID:11573
Streptococcal meningitis	off-label use	4510004	DOID:11574
Typhoid fever	off-label use	4834000	DOID:13258
Pyrexia of unknown origin	off-label use	7520000
Inhalational anthrax	off-label use	11389007
Listeria meningitis	off-label use	31568009	DOID:11572
Pseudotuberculosis	off-label use	36753006
Enterocolitis	off-label use	43752006
Infection of bone	off-label use	111253001
Gastrointestinal anthrax	off-label use	111798006	DOID:13386
Infection by Campylobacter fetus	off-label use	111835002
Listerial endocarditis	off-label use	186318004
Sepsis of the newborn	off-label use	206376005
Neonatal pneumonia	off-label use	233619008
Human bite - wound	off-label use	262555007
Diverticulitis of gastrointestinal tract	off-label use	271366000
Neonatal meningitis	off-label use	276674008
Dog bite - wound	off-label use	283734005
Cat bite - wound	off-label use	283782004
Cutaneous listeriosis	off-label use	402128003
Anthrax	off-label use	409498004	DOID:7427
Pharyngitis due to Haemophilus Parainfluenzae	off-label use
Haemophilus Parainfluenzae Chronic Bronchitis	off-label use
Listeria Osteomyelitis	off-label use
Haemophilus Parainfluenzae Acute Otitis Media	off-label use
Diabetic Foot Infection	off-label use
Haemophilus Parainfluenzae Pneumonia	off-label use
H. Influenzae Meningitis	off-label use
Listeria Septic Arthritis	off-label use
Granulomatosis Infantiseptica	off-label use
Listeria Monocytogenes Septicemia	off-label use
Prevention of Neonatal Group B Streptococcal Infection	off-label use
Prevention of Bacterial Endocarditis	off-label use
Peptic ulcer	contraindication	13200003	DOID:750
Acute nephropathy	contraindication	58574008
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Impaired renal function disorder	contraindication	197663003
Infectious mononucleosis	contraindication	271558008	DOID:8568
Uric acid renal calculus	contraindication	274401005
Pseudomembranous enterocolitis	contraindication	397683000
Uric Acid Nephropathy Gout	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Skin, Soft Tissue and Post-Surgical Infections caused by Escherichia coli	Indication
Cats	Skin, Soft Tissue and Post-Surgical Infections caused by Proteus mirabilis	Indication
Cats	Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci	Indication
Cats	Skin, Soft Tissue and Post-Surgical Infections caused by Staphylococcus spp	Indication
Cats	Skin, Soft Tissue and Post-Surgical Infections caused by Pasteurella spp	Indication
Cats	Urinary Tract Infections caused by Proteus mirabilis	Indication
Cats	Urinary Tract Infections caused by Escherichia coli	Indication
Cats	Urinary tract infections caused by Staphylococcus species	Indication
Cats	Urinary Tract Infections caused by hemolytic streptococci	Indication
Cats	Urinary Tract Infections caused by Enterococcus spp	Indication
Cats	Upper respiratory infections caused by hemolytic streptococci	Indication
Cats	Upper respiratory infections caused by Staphylococcus aureus	Indication
Cats	Upper respiratory infections caused by Escherichia coli	Indication
Cats	Upper respiratory infections caused by Proteus mirabilis	Indication
Cats	Upper respiratory infections caused by Pasteurella spp	Indication
Cats	Gastrointestinal Infections caused by Enterococcus spp	Indication
Cats	Gastrointestinal Infections caused by Staphylococcus spp	Indication
Cats	Gastrointestinal Infections caused by Escherichia coli	Indication
Cats	Tonsillitis caused by Escherichia coli	Indication
Cats	Tonsillitis caused by hemolytic streptococci	Indication
Cats	Tonsillitis caused by Pasteurella spp	Indication
Cats	Tonsillitis caused by Proteus mirabilis	Indication
Cats	Tonsillitis caused by Staphylococcus aureus	Indication
Cats	Bronchopneumonia caused by Escherichia coli	Indication
Cats	Bronchopneumonia caused by hemolytic streptococci	Indication
Cats	Bronchopneumonia caused by Pasteurella spp	Indication
Cats	Bronchopneumonia caused by Proteus mirabilis	Indication
Cats	Bronchopneumonia caused by Staphylococcus aureus	Indication
Cats	Abscesses caused by hemolytic streptococci	Indication
Cats	Abscesses caused by Escherichia coli	Indication
Cats	Abscesses caused by Pasteurella spp	Indication
Cats	Abscesses caused by Proteus mirabilis	Indication
Cats	Abscesses caused by Staphylococcus spp	Indication
Cats	Pustular dermatitis caused by hemolytic streptococci	Indication
Cats	Pustular dermatitis caused by Escherichia coli	Indication
Cats	Pustular dermatitis caused by Pasteurella spp	Indication
Cats	Pustular dermatitis caused by Proteus mirabilis	Indication
Cats	Pustular dermatitis caused by Staphylococcus spp	Indication
Cats	Cellulitis caused by hemolytic streptococci	Indication
Cats	Cellulitis caused by Escherichia coli	Indication
Cats	Cellulitis caused by Pasteurella spp	Indication
Cats	Cellulitis caused by Proteus mirabilis	Indication
Cats	Cellulitis caused by Staphylococcus spp	Indication
Cats	Infections of the anal gland caused by hemolytic streptococci	Indication
Cats	Infections of the anal gland caused by Escherichia coli	Indication
Cats	Infections of the anal gland caused by Pasteurella spp	Indication
Cats	Infections of the anal gland caused by Proteus mirabilis	Indication
Cats	Infections of the anal gland caused by Staphylococcus spp	Indication
Cattle	Bacterial pneumonia caused by Aerobacter spp	Indication
Cattle	Bacterial pneumonia caused by Klebsiella spp	Indication
Cattle	Bacterial pneumonia caused by Staphylococcus spp	Indication
Cattle	Bacterial pneumonia caused by Streptococcus spp	Indication
Cattle	Bacterial pneumonia caused by Pasteurella multocida	Indication
Cattle	Bacterial pneumonia caused by Escherichia coli	Indication
Dogs	Skin, Soft Tissue and Post-Surgical Infections caused by Escherichia coli	Indication
Dogs	Skin, Soft Tissue and Post-Surgical Infections caused by Proteus mirabilis	Indication
Dogs	Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci	Indication
Dogs	Skin, Soft Tissue and Post-Surgical Infections caused by Staphylococcus spp	Indication
Dogs	Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci	Indication
Dogs	Upper respiratory infections caused by hemolytic streptococci	Indication
Dogs	Upper respiratory infections caused by Staphylococcus aureus	Indication
Dogs	Upper respiratory infections caused by Escherichia coli	Indication
Dogs	Upper respiratory infections caused by Proteus mirabilis	Indication
Dogs	Upper respiratory infections caused by Pasteurella spp	Indication
Dogs	Urinary Tract Infections caused by Proteus mirabilis	Indication
Dogs	Urinary Tract Infections caused by Escherichia coli	Indication
Dogs	Urinary tract infections caused by Staphylococcus species	Indication
Dogs	Urinary Tract Infections caused by hemolytic streptococci	Indication
Dogs	Urinary Tract Infections caused by Enterococcus spp	Indication
Dogs	Gastrointestinal Infections caused by Enterococcus spp	Indication
Dogs	Gastrointestinal Infections caused by Staphylococcus spp	Indication
Dogs	Gastrointestinal Infections caused by Escherichia coli	Indication
Dogs	Tonsillitis caused by Escherichia coli	Indication
Dogs	Tonsillitis caused by hemolytic streptococci	Indication
Dogs	Tonsillitis caused by Pasteurella spp	Indication
Dogs	Tonsillitis caused by Proteus mirabilis	Indication
Dogs	Tonsillitis caused by Staphylococcus aureus	Indication
Dogs	Bronchopneumonia caused by Escherichia coli	Indication
Dogs	Bronchopneumonia caused by hemolytic streptococci	Indication
Dogs	Bronchopneumonia caused by Pasteurella spp	Indication
Dogs	Bronchopneumonia caused by Proteus mirabilis	Indication
Dogs	Bronchopneumonia caused by Staphylococcus aureus	Indication
Dogs	Abscesses caused by Staphylococcus spp	Indication
Dogs	Pustular dermatitis caused by Staphylococcus spp	Indication
Dogs	Cellulitis caused by Staphylococcus spp	Indication
Dogs	Infections of the anal gland caused by Staphylococcus spp	Indication
Dogs	Abscesses caused by hemolytic streptococci	Indication
Dogs	Abscesses caused by Escherichia coli	Indication
Dogs	Abscesses caused by hemolytic streptococci	Indication
Dogs	Abscesses caused by Proteus mirabilis	Indication
Dogs	Pustular dermatitis caused by hemolytic streptococci	Indication
Dogs	Pustular dermatitis caused by Escherichia coli	Indication
Dogs	Pustular dermatitis caused by hemolytic streptococci	Indication
Dogs	Pustular dermatitis caused by Proteus mirabilis	Indication
Dogs	Cellulitis caused by hemolytic streptococci	Indication
Dogs	Cellulitis caused by Escherichia coli	Indication
Dogs	Cellulitis caused by hemolytic streptococci	Indication
Dogs	Cellulitis caused by Proteus mirabilis	Indication
Dogs	Infections of the anal gland caused by hemolytic streptococci	Indication
Dogs	Infections of the anal gland caused by Escherichia coli	Indication
Dogs	Infections of the anal gland caused by hemolytic streptococci	Indication
Dogs	Infections of the anal gland caused by Proteus mirabilis	Indication
Horses	Respiratory tract infections caused by Staphylococcus species	Indication
Horses	Respiratory tract infections caused by Escherichia coli	Indication
Horses	Respiratory tract infections caused by Proteus mirabilis	Indication
Horses	Skin and soft tissue infections caused by Staphylococcus spp	Indication
Horses	Skin and soft tissue infections caused by Streptococcus spp	Indication
Horses	Skin and soft tissue infections caused by Escherichia coli	Indication
Horses	Skin and soft tissue infections caused by Proteus mirabilis	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Omnipen 250 mg	Zoetis Inc.	1
Polyflex	Boehringer lngelheim Animal Health USA Inc.	1
Ampi-Tab	Zoetis Inc.	1
Princillin Injection	Zoetis Inc.	1
Princillin Injection	Zoetis Inc.	1
Princillin Injection 200 mg	Zoetis Inc.	1
Ampi-Bol	Zoetis Inc.	1
Ampi-Ject	Zoetis Inc.	1
Amp-Equine	Zoetis Inc.	1
Ampicillin Trihydrate	HQ Specialty Pharma Corp.	1
Ampicillin Sodium	HQ Specialty Pharma Corp.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.79	acidic
pKa2	7.67	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)