doxylamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
962 469-21-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxylamine
  • (+/-)-Doxylamine
  • doxylamine succinate
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.
  • Molecular weight: 270.38
  • Formula: C17H22N2O
  • CLOGP: 2.35
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 25.36
  • ALOGS: -2.70
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 24.70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Bocci G, Oprea TI, Benet LZ
fu (Fraction unbound in plasma) 0.51 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.682 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.914 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 27.290 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 12.359 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 78.830 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 65.580 % High 1
herg hERG pIC50 4.689 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.972 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.943 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 73.900 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 35
kinase-selectivity-class AXL,ERBB2,PDK4,SIK2 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.708 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.993 High 1
mh-clint Mouse hepatocyte intrinsic clearance 57.412 High 1
mppb Mouse plasma protein binding (% unbound) 78.830 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.582 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 79.920 % High 1
rat-kpuu-brain Rat brain Kpuu 0.478 % High 1
rh-clint Rat hepatocyte intrinsic clearance 79.616 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.350 % High 1
rppb Rat plasma protein binding (% unbound) 77.460 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 912.011 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 7, 1948 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 4549.81 10.11 8609 779825 279237 89560776
Completed suicide 3154.74 10.11 5000 783434 140058 89699955
Exposure to toxic agent 1994.33 10.11 1094 787340 6873 89833140
Intentional overdose 1647.66 10.11 2941 785493 90893 89749120
Acute hepatic failure 1198.70 10.11 1216 787218 21345 89818668
Overdose 1051.94 10.11 3391 785043 154318 89685695
Infusion related reaction 795.98 10.11 6273 782161 410507 89429506
Hepatic cytolysis 783.10 10.11 1145 787289 29771 89810242
Suicide attempt 700.29 10.11 1826 786608 73573 89766440
Injection site pain 670.82 10.11 336 788098 173363 89666650
Metabolic acidosis 582.58 10.11 1411 787023 54265 89785748
Product dose omission issue 560.67 10.11 1052 787382 290635 89549378
Poisoning deliberate 545.41 10.11 695 787739 15791 89824222
Intentional product misuse 520.50 10.11 1840 786594 87764 89752249
Folliculitis 460.56 10.11 3201 785233 201152 89638861
Lower respiratory tract infection 450.09 10.11 3722 784712 246937 89593076
Blood pressure fluctuation 444.94 10.11 1228 787206 51185 89788828
Analgesic drug level increased 410.33 10.11 277 788157 2642 89837371
Muscle injury 408.58 10.11 2785 785649 173869 89666144
Sinusitis 408.41 10.11 4673 783761 338415 89501598
Drug ineffective 397.79 10.11 9103 779331 1375195 88464818
Irritable bowel syndrome 375.31 10.11 3086 785348 204362 89635651
Duodenal ulcer perforation 366.15 10.11 3227 785207 218061 89621952
Injection site erythema 357.55 10.11 206 788228 98296 89741717
Rheumatoid arthritis 352.37 10.11 4755 783679 357859 89482154
Helicobacter infection 351.81 10.11 3262 785172 223588 89616425
Ill-defined disorder 344.45 10.11 2769 785665 182122 89657891
Blister 343.34 10.11 3560 784874 251438 89588575
Sleep disorder due to general medical condition, insomnia type 334.77 10.11 2090 786344 126604 89713409
Hepatic enzyme increased 324.44 10.11 4666 783768 356070 89483943
Diarrhoea 314.72 10.11 6020 782414 933170 88906843
Pericarditis 313.86 10.11 3663 784771 266488 89573525
Anti-cyclic citrullinated peptide antibody positive 304.72 10.11 3272 785162 233161 89606852
Impaired healing 304.59 10.11 3247 785187 230952 89609061
Device expulsion 299.75 10.11 13 788421 40873 89799140
Suspected suicide attempt 291.77 10.11 147 788287 754 89839259
Suspected suicide 287.94 10.11 385 788049 9183 89830830
Medication error 260.36 10.11 1437 786997 83215 89756798
Wrong technique in product usage process 259.28 10.11 150 788284 71421 89768592
Nasopharyngitis 247.13 10.11 4941 783493 402163 89437850
Pyroglutamic acidosis 246.03 10.11 148 788286 1132 89838881
Depressed level of consciousness 245.97 10.11 1268 787166 71516 89768497
Disease progression 238.48 10.11 641 787793 155974 89684039
Throat irritation 237.00 10.11 945 787489 47750 89792263
Gastrointestinal disorder 234.88 10.11 3331 785103 253356 89586657
Anion gap 232.42 10.11 137 788297 1005 89839008
Joint swelling 227.75 10.11 5860 782574 497440 89342573
Hypersensitivity 223.29 10.11 5353 783081 449324 89390689
Anaemia 222.98 10.11 1978 786456 350824 89489189
Malignant neoplasm progression 219.94 10.11 369 788065 106501 89733512
Cardiac failure congestive 215.15 10.11 328 788106 98366 89741647
Hand deformity 211.60 10.11 3689 784745 292673 89547340
Synovitis 206.99 10.11 4023 784411 325729 89514284
Myelosuppression 206.28 10.11 104 788330 53487 89786526
Intentional product use issue 202.56 10.11 2825 785609 214067 89625946
Injection site pruritus 200.51 10.11 109 788325 53725 89786288
Hepatotoxicity 194.46 10.11 853 787581 44989 89795024
Injection site bruising 191.79 10.11 108 788326 52199 89787814
Stomatitis 191.67 10.11 3407 785027 271291 89568722
Injection site swelling 190.33 10.11 145 788289 59694 89780319
Liver injury 182.72 10.11 2278 786156 168289 89671724
White blood cell count decreased 179.21 10.11 795 787639 166314 89673699
Confusional state 178.74 10.11 4511 783923 381694 89458319
Coagulopathy 176.59 10.11 524 787910 22765 89817248
Discomfort 171.78 10.11 3346 785088 270989 89569024
Body temperature increased 170.33 10.11 806 787628 43904 89796109
Feeling abnormal 166.70 10.11 817 787617 166418 89673595
Wound 165.31 10.11 3621 784813 299359 89540654
Neutropenia 164.00 10.11 1213 787221 223691 89616322
Therapy interrupted 162.48 10.11 119 788315 49989 89790024
Ear pruritus 162.26 10.11 245 788189 6558 89833455
Neuropathy peripheral 162.20 10.11 627 787807 136343 89703670
Blood pressure systolic abnormal 159.01 10.11 450 787984 19028 89820985
Therapeutic product effect decreased 154.17 10.11 3326 785108 274245 89565768
Rheumatic fever 150.50 10.11 2013 786421 151108 89688905
Weight increased 145.50 10.11 4709 783725 413218 89426795
Dry skin 142.08 10.11 350 788084 87723 89752290
Myocardial infarction 141.55 10.11 461 787973 105511 89734502
Coma 141.27 10.11 1099 787335 71533 89768480
Blood pressure diastolic abnormal 139.20 10.11 435 787999 19446 89820567
Therapy cessation 137.80 10.11 72 788362 36289 89803724
Surgery 137.43 10.11 113 788321 44774 89795239
Swelling 136.74 10.11 4686 783748 414372 89425641
Unevaluable event 127.69 10.11 174 788260 54674 89785339
Prothrombin time ratio decreased 127.06 10.11 89 788345 906 89839107
Hepatic failure 123.19 10.11 676 787758 39052 89800961
Hospitalisation 122.97 10.11 634 787800 127466 89712547
Blood pressure systolic increased 122.57 10.11 899 787535 57446 89782567
Blood pressure diastolic decreased 122.12 10.11 510 787924 26316 89813697
Sedation complication 120.73 10.11 373 788061 16571 89823442
Cardiac failure 119.74 10.11 517 787917 108979 89731034
Neoplasm progression 118.54 10.11 127 788307 44359 89795654
Device dislocation 118.33 10.11 63 788371 31419 89808594
Cytokine release syndrome 117.49 10.11 519 787915 27454 89812559
Muscle spasticity 116.29 10.11 611 787823 34711 89805302
Heart rate decreased 115.61 10.11 830 787604 52675 89787338
Glossodynia 113.55 10.11 3632 784802 318147 89521866
Drug abuse 110.80 10.11 1150 787284 81197 89758816
Rheumatoid factor positive 110.56 10.11 2103 786331 169547 89670466
Poisoning 107.51 10.11 334 788100 14883 89825130
Bone pain 107.45 10.11 237 788197 61746 89778267
Creatinine renal clearance decreased 107.02 10.11 385 788049 18514 89821499
Renal impairment 106.77 10.11 512 787922 104909 89735104
Dehydration 105.50 10.11 1131 787303 193316 89646697
Osteonecrosis of jaw 104.90 10.11 111 788323 38992 89801021
Cardio-respiratory arrest 104.90 10.11 922 787512 62218 89777795
Dermatitis atopic 102.32 10.11 38 788396 23434 89816579
Mobility decreased 101.88 10.11 2880 785554 247854 89592159
Psoriasis 101.50 10.11 810 787624 146944 89693069
Pancytopenia 100.39 10.11 623 787811 119640 89720373
Product storage error 100.37 10.11 26 788408 20215 89819798
Myalgia 100.16 10.11 1006 787428 174119 89665894
Diabetes mellitus 99.10 10.11 265 788169 64610 89775403
Nausea 98.77 10.11 8319 780115 1101997 88738016
Infection 98.46 10.11 3968 784466 358126 89481887
Seizure 97.92 10.11 852 787582 151777 89688236
Drug resistance 97.83 10.11 73 788361 30376 89809637
Device malfunction 96.55 10.11 31 788403 20946 89819067
Injection site haemorrhage 96.11 10.11 64 788370 28254 89811759
Device difficult to use 96.02 10.11 18 788416 17507 89822506
Swollen joint count increased 95.60 10.11 1428 787006 109778 89730235
Product substitution issue 95.51 10.11 20 788414 17988 89822025
Accidental overdose 95.10 10.11 492 787942 27781 89812232
Abortion spontaneous 95.10 10.11 205 788229 53851 89786162
Dizziness 93.69 10.11 4181 784253 585103 89254910
Injection site urticaria 93.50 10.11 21 788413 17990 89822023
Platelet count decreased 93.10 10.11 753 787681 136216 89703797
Injection site rash 92.89 10.11 47 788387 24126 89815887
Pemphigus 92.36 10.11 3597 784837 323267 89516746
Injection site warmth 91.77 10.11 20 788414 17495 89822518
Vision blurred 90.17 10.11 575 787859 109718 89730295
Injury 89.33 10.11 2299 786135 195050 89644963
Cerebrovascular accident 88.21 10.11 670 787764 122863 89717150
Respiratory depression 87.95 10.11 317 788117 15258 89824755
Accidental exposure to product 87.40 10.11 146 788288 42220 89797793
Type 2 diabetes mellitus 86.90 10.11 2350 786084 200894 89639119
Arthropathy 86.68 10.11 3956 784478 362286 89477727
Respiratory failure 85.63 10.11 640 787794 117778 89722235
Respiratory arrest 84.69 10.11 538 787896 32773 89807240
Breast cancer 84.10 10.11 217 788217 53544 89786469
Device issue 83.63 10.11 80 788354 29457 89810556
Infusion site swelling 83.50 10.11 258 788176 11462 89828551
Red blood cell sedimentation rate abnormal 83.10 10.11 54 788380 24150 89815863
Full blood count abnormal 82.30 10.11 119 788315 36478 89803535
Peripheral swelling 82.11 10.11 4387 784047 408719 89431294
Dyspnoea exertional 81.69 10.11 337 788097 71951 89768062
Loss of consciousness 81.68 10.11 802 787632 139436 89700577
Hepatic necrosis 81.54 10.11 176 788258 6262 89833751
Renal failure 81.53 10.11 737 787697 130270 89709743
Schizoaffective disorder 81.01 10.11 154 788280 4993 89835020
Atrial fibrillation 79.12 10.11 761 787673 132850 89707163
Infusion site pruritus 78.97 10.11 179 788255 6586 89833427
Acute lung injury 78.20 10.11 80 788354 1418 89838595
Visual acuity reduced 77.99 10.11 54 788380 23356 89816657
Blood cholesterol increased 77.83 10.11 2365 786069 205647 89634366
Drug use disorder 77.35 10.11 202 788232 8141 89831872
Urinary tract infection 77.03 10.11 2046 786388 303586 89536427
Infusion site pain 76.76 10.11 358 788076 19380 89820633
Contusion 76.07 10.11 2786 785648 248430 89591583
Pyroglutamate increased 75.75 10.11 44 788390 313 89839700
Palmar-plantar erythrodysaesthesia syndrome 74.66 10.11 80 788354 27943 89812070
Blood calcium decreased 74.60 10.11 484 787950 29698 89810315
Interstitial lung disease 73.96 10.11 377 788057 76028 89763985
Injection site mass 73.53 10.11 51 788383 22039 89817974
Injection site reaction 72.76 10.11 485 787949 91595 89748418
Infusion site erythema 71.97 10.11 272 788162 13398 89826615
Drug-induced liver injury 71.96 10.11 1145 787289 89173 89750840
Transient ischaemic attack 71.67 10.11 169 788265 43007 89797006
Oxygen saturation decreased 71.30 10.11 1323 787111 106160 89733853
Blood glucose increased 71.15 10.11 510 787924 94736 89745277
Systemic lupus erythematosus 70.46 10.11 3836 784598 358060 89481953
Night sweats 70.45 10.11 1540 786894 127226 89712787
Gastrointestinal haemorrhage 69.99 10.11 478 787956 89770 89750243
Epistaxis 69.99 10.11 443 787991 84682 89755331
Ear pain 69.37 10.11 788 787646 56914 89783099
Bone marrow failure 69.32 10.11 108 788326 32113 89807900
Full blood count decreased 69.29 10.11 94 788340 29595 89810418
Prothrombin time shortened 69.06 10.11 92 788342 2186 89837827
Multiple sclerosis relapse 68.82 10.11 229 788205 52076 89787937
Pharyngeal paraesthesia 68.28 10.11 109 788325 3065 89836948
Hepatitis acute 67.02 10.11 228 788206 10659 89829354
Blood pressure increased 66.63 10.11 2215 786219 195002 89645011
Leukopenia 66.00 10.11 559 787875 100151 89739862
No adverse event 65.48 10.11 336 788098 67646 89772367
Hypothyroidism 64.94 10.11 240 788194 52887 89787126
Suicidal ideation 64.56 10.11 377 788057 73478 89766535
Metastases to bone 64.47 10.11 76 788358 25429 89814584
Therapeutic product effect incomplete 64.44 10.11 1243 787191 192653 89647360
Drug dose omission by device 64.21 10.11 7 788427 10224 89829789
Tremor 63.92 10.11 942 787492 152231 89687782
Posterior reversible encephalopathy syndrome 63.84 10.11 60 788374 22279 89817734
Pyrexia 63.83 10.11 6620 781814 653865 89186148
Contraindicated product administered 63.61 10.11 3400 785034 316739 89523274
Metastases to liver 63.47 10.11 95 788339 28712 89811301
Therapeutic response unexpected 63.43 10.11 58 788376 21822 89818191
Pulmonary hypertension 63.22 10.11 176 788258 42347 89797666
Thrombosis 62.40 10.11 377 788057 72874 89767139
Myelodysplastic syndrome 62.29 10.11 54 788380 20849 89819164
Hypocoagulable state 61.93 10.11 73 788361 1526 89838487
Hypomania 61.67 10.11 194 788240 8703 89831310
Schizophrenia 61.34 10.11 275 788159 14639 89825374
Fall 61.33 10.11 3497 784937 478313 89361700
Deep vein thrombosis 61.19 10.11 506 787928 91114 89748899
Coronary artery disease 60.41 10.11 126 788308 33497 89806516
Depression 60.02 10.11 2076 786358 298525 89541488
Sopor 59.59 10.11 76 788358 24568 89815445
Facet joint syndrome 59.45 10.11 1194 787240 97195 89742818
Sepsis 59.06 10.11 1155 787279 178659 89661354
Breast cancer female 58.63 10.11 28 788406 14858 89825155
Impaired quality of life 58.46 10.11 69 788365 23075 89816938
Cardiac disorder 58.29 10.11 275 788159 56597 89783416
Hypocalcaemia 58.18 10.11 182 788252 42186 89797827
Syncope 58.12 10.11 808 787626 131855 89708158
Disease recurrence 58.11 10.11 153 788281 37500 89802513
Haemorrhage 58.06 10.11 359 788075 69010 89771003
Bursitis 57.32 10.11 1526 786908 130128 89709885
Hepatitis fulminant 57.18 10.11 114 788320 3831 89836182
Blood potassium decreased 56.78 10.11 218 788216 47509 89792504
Drug level increased 56.73 10.11 425 788009 27337 89812676
Exposure via ingestion 56.57 10.11 91 788343 2576 89837437
Anion gap abnormal 56.03 10.11 37 788397 339 89839674
Hepatic encephalopathy 55.93 10.11 253 788181 13519 89826494
Hypokalaemia 55.87 10.11 803 787631 130313 89709700
Jaundice cholestatic 55.52 10.11 203 788231 9840 89830173
Pulmonary embolism 55.46 10.11 802 787632 130018 89709995
Hyperlipidaemia 55.07 10.11 71 788363 22845 89817168
Carpal tunnel syndrome 54.60 10.11 77 788357 23851 89816162
Cognitive disorder 54.57 10.11 878 787556 68529 89771484
Brain oedema 54.01 10.11 296 788138 17089 89822924
Basal cell carcinoma 53.59 10.11 133 788301 33256 89806757
Decreased appetite 53.10 10.11 2705 785729 373835 89466178
Drug hypersensitivity 52.79 10.11 3400 785034 460209 89379804
Infusion site extravasation 52.32 10.11 203 788231 10125 89829888
Product dose omission in error 51.93 10.11 61 788373 20442 89819571
Haematotoxicity 51.84 10.11 22 788412 12513 89827500
Electric shock 51.37 10.11 69 788365 1653 89838360
Muscle spasms 51.33 10.11 1735 786699 250148 89589865
Injection site induration 50.86 10.11 14 788420 10454 89829559
Exposure via skin contact 50.74 10.11 15 788419 10690 89829323
Drug withdrawal syndrome 50.46 10.11 109 788325 28614 89811399
Lip dry 50.10 10.11 1191 787243 99764 89740249
Cellulitis 50.01 10.11 530 787904 90807 89749206
Ductus arteriosus premature closure 49.71 10.11 36 788398 388 89839625
Spinal stenosis 49.55 10.11 47 788387 17377 89822636
Thrombotic microangiopathy 48.98 10.11 39 788395 15704 89824309
Complication of device insertion 48.79 10.11 15 788419 10421 89829592
Pain in extremity 48.77 10.11 3319 785115 447210 89392803
Orthostatic hypotension 48.39 10.11 567 787867 41260 89798753
Fibromyalgia 48.29 10.11 2226 786208 204043 89635970
Poor venous access 48.17 10.11 313 788121 19214 89820799
Injection site discolouration 48.11 10.11 11 788423 9309 89830704
Metastases to lung 48.03 10.11 41 788393 15950 89824063
Heart rate increased 47.53 10.11 1303 787131 111599 89728414
Hyponatraemia 47.49 10.11 846 787588 132692 89707321
Septic shock 47.04 10.11 486 787948 83674 89756339
Mucosal inflammation 46.79 10.11 301 788133 57324 89782689
Osteonecrosis 46.59 10.11 99 788335 26142 89813871
Joint range of motion decreased 46.20 10.11 1525 786909 134118 89705895
Chronic kidney disease 46.14 10.11 252 788182 49939 89790074
Vaginal haemorrhage 46.06 10.11 130 788304 31141 89808872
Skin burning sensation 45.86 10.11 62 788372 19549 89820464
Skin exfoliation 45.84 10.11 374 788060 67539 89772474
Eczema 45.61 10.11 271 788163 52599 89787414
Genital haemorrhage 45.46 10.11 10 788424 8692 89831321
Neurotoxicity 45.19 10.11 73 788361 21394 89818619
Drug intolerance 44.70 10.11 4497 783937 443094 89396919
Sleep apnoea syndrome 44.57 10.11 135 788299 31612 89808401
Diabetic ketoacidosis 44.24 10.11 91 788343 24316 89815697
Plasma cell myeloma 43.88 10.11 194 788240 40634 89799379
Renal disorder 43.08 10.11 176 788258 37683 89802330
Pathogen resistance 43.06 10.11 9 788425 8106 89831907
Post transplant lymphoproliferative disorder 42.99 10.11 5 788429 6944 89833069
Complication of device removal 42.72 10.11 3 788431 6252 89833761
Multiple-drug resistance 42.57 10.11 8 788426 7768 89832245
Product preparation error 42.45 10.11 18 788416 10243 89829770
Pneumocystis jirovecii pneumonia 42.31 10.11 77 788357 21539 89818474
Device breakage 42.19 10.11 36 788398 14008 89826005
Femur fracture 42.02 10.11 232 788202 45850 89794163
Dysgeusia 41.94 10.11 276 788158 52284 89787729
Transplant rejection 41.75 10.11 30 788404 12728 89827285
Neutrophil count decreased 41.67 10.11 409 788025 71123 89768890
Heart rate irregular 41.67 10.11 357 788077 23911 89816102
Ascites 41.56 10.11 244 788190 47496 89792517
Dyskinesia 41.47 10.11 170 788264 36364 89803649
Urticaria 41.40 10.11 3208 785226 309526 89530487
Clostridium test positive 41.40 10.11 122 788312 5279 89834734
Cerebral infarction 41.10 10.11 108 788326 26488 89813525
Hyperkalaemia 41.04 10.11 364 788070 64600 89775413
Rash pruritic 40.71 10.11 488 787946 81726 89758287
Hypothermia 40.49 10.11 253 788181 15322 89824691
Device use error 40.46 10.11 7 788427 7214 89832799
Pulmonary arterial hypertension 39.97 10.11 107 788327 26080 89813933
Deep vein thrombosis postoperative 39.72 10.11 850 787584 69959 89770054
Blood pressure diastolic increased 39.60 10.11 219 788215 12687 89827326
Polyneuropathy 39.57 10.11 67 788367 19274 89820739
Dry eye 39.57 10.11 318 788116 57613 89782400
Pleural effusion 39.03 10.11 712 787722 111279 89728734
Crystal urine present 38.91 10.11 56 788378 1434 89838579
Right ventricular failure 38.86 10.11 67 788367 19138 89820875
Dyspnoea 38.73 10.11 6910 781524 874045 88965968
Skin discolouration 38.31 10.11 227 788207 44088 89795925
White blood cells urine positive 38.19 10.11 134 788300 6364 89833649
Thinking abnormal 37.85 10.11 28 788406 11704 89828309
Ageusia 37.41 10.11 51 788383 16025 89823988
Irritability 37.39 10.11 171 788263 35491 89804522
Acute myeloid leukaemia 37.37 10.11 77 788357 20563 89819450
Respiratory disorder 37.31 10.11 781 787653 64035 89775978
Product prescribing error 36.96 10.11 136 788298 30009 89810004
Hypertensive crisis 36.95 10.11 61 788373 17723 89822290
Dermatitis 36.86 10.11 87 788347 22133 89817880
Acute myocardial infarction 36.76 10.11 167 788267 34723 89805290
Cytomegalovirus infection 36.72 10.11 114 788320 26488 89813525
Tardive dyskinesia 36.69 10.11 25 788409 10905 89829108
Complication associated with device 36.55 10.11 71 788363 19378 89820635
Palpitations 36.35 10.11 908 787526 135820 89704193
Anticipatory anxiety 36.16 10.11 49 788385 1184 89838829
Coeliac disease 36.07 10.11 567 787867 44043 89795970
Multiple drug therapy 35.70 10.11 138 788296 6871 89833142
Cardiac failure acute 35.33 10.11 31 788403 11898 89828115
Pain in jaw 35.32 10.11 258 788176 47727 89792286
Burning sensation 35.22 10.11 367 788067 63085 89776928
Flatulence 35.18 10.11 213 788221 41154 89798859
Uterine perforation 35.06 10.11 11 788423 7543 89832470
Gait disturbance 34.87 10.11 1881 786553 258615 89581398
Sensitivity to weather change 34.75 10.11 17 788417 8897 89831116
Musculoskeletal disorder 34.72 10.11 87 788347 21682 89818331
Body temperature decreased 34.62 10.11 338 788096 23478 89816535
Haemoglobin decreased 34.53 10.11 1109 787325 160847 89679166
Dissociation 34.51 10.11 8 788426 6707 89833306
Second primary malignancy 34.49 10.11 24 788410 10354 89829659
Heavy menstrual bleeding 34.36 10.11 80 788354 20450 89819563
Sleep disorder 34.23 10.11 2077 786357 195953 89644060
Skin ulcer 34.14 10.11 275 788159 49800 89790213
Amenorrhoea 34.07 10.11 31 788403 11691 89828322
Drug tolerance 34.02 10.11 65 788369 17851 89822162
Therapeutic response decreased 33.98 10.11 562 787872 89167 89750846
Mixed liver injury 33.97 10.11 144 788290 7479 89832534
Inflammation 33.71 10.11 1888 786546 176704 89663309
Hypercalcaemia 33.67 10.11 168 788266 34072 89805941
Product adhesion issue 33.63 10.11 3 788431 5139 89834874
Staphylococcal infection 33.50 10.11 265 788169 48174 89791839
Product complaint 33.30 10.11 41 788393 13459 89826554
Hypotension 33.28 10.11 3275 785159 322122 89517891
Premature delivery 33.27 10.11 199 788235 38563 89801450
Cholestasis 33.10 10.11 471 787963 35828 89804185
Hypomagnesaemia 33.09 10.11 178 788256 35410 89804603
Administration site swelling 32.97 10.11 52 788382 1447 89838566
Thrombocytopenia 32.83 10.11 1482 786952 207243 89632770
Infusion site bruising 32.79 10.11 98 788336 4274 89835739
Foot operation 32.40 10.11 19 788415 8982 89831031
Eye pruritus 32.37 10.11 136 788298 28891 89811122
Oedema peripheral 32.20 10.11 1875 786559 256040 89583973
Treatment noncompliance 32.16 10.11 291 788143 51436 89788577
Urine abnormality 32.07 10.11 143 788291 7594 89832419
Cardiomyopathy 32.03 10.11 81 788353 20125 89819888
Sedation 31.95 10.11 593 787841 47578 89792435
Skin necrosis 31.70 10.11 62 788372 16879 89823134
Cytopenia 31.67 10.11 65 788369 17384 89822629
Gastric disorder 31.58 10.11 166 788268 33218 89806795
Weight fluctuation 31.57 10.11 286 788148 19463 89820550
Analgesic drug level above therapeutic 31.41 10.11 19 788415 147 89839866
Product use issue 31.37 10.11 3304 785130 326615 89513398
Immune reconstitution inflammatory syndrome 31.21 10.11 11 788423 7008 89833005
Neoplasm malignant 31.20 10.11 170 788264 33710 89806303
Respiratory rate increased 31.04 10.11 242 788192 15759 89824254
Autoimmune disorder 30.98 10.11 881 787553 75863 89764150
Mitral valve incompetence 30.75 10.11 97 788337 22427 89817586
Pre-existing condition improved 30.74 10.11 21 788413 9148 89830865
Unintended pregnancy 30.64 10.11 14 788420 7623 89832390
Urinary sediment present 30.53 10.11 62 788372 2112 89837901
Eye irritation 30.47 10.11 172 788262 33806 89806207
Ankylosing spondylitis 30.23 10.11 42 788392 13091 89826922
Fracture 30.19 10.11 95 788339 21981 89818032
Infective pulmonary exacerbation of cystic fibrosis 30.09 10.11 27 788407 10252 89829761
Hypercholesterolaemia 30.04 10.11 1117 787317 99775 89740238
Urine leukocyte esterase positive 29.95 10.11 79 788355 3203 89836810
Anion gap increased 29.83 10.11 63 788371 2207 89837806
Ductus arteriosus stenosis foetal 29.80 10.11 21 788413 216 89839797
Iron deficiency anaemia 29.50 10.11 106 788328 23556 89816457
Hyperglycaemia 29.45 10.11 292 788142 50678 89789335
Incorrect dose administered 29.35 10.11 496 787938 78434 89761579
Food allergy 29.30 10.11 345 788089 25133 89814880
Paraesthesia 29.28 10.11 1831 786603 248495 89591518
Incorrect dose administered by device 29.16 10.11 7 788427 5730 89834283
Brain death 29.09 10.11 89 788345 3932 89836081
Oral pruritus 28.96 10.11 73 788361 2878 89837135
Meniscus injury 28.79 10.11 18 788416 8219 89831794
Cerebral haemorrhage 28.71 10.11 179 788255 34343 89805670
Intermenstrual bleeding 28.50 10.11 23 788411 9200 89830813
Gestational diabetes 28.43 10.11 30 788404 10552 89829461
Tinnitus 28.34 10.11 239 788195 42863 89797150
Specific gravity urine decreased 28.32 10.11 35 788399 770 89839243
Infusion site rash 28.21 10.11 65 788369 2418 89837595
Speech disorder 28.10 10.11 257 788177 45328 89794685
Pericardial effusion 28.10 10.11 196 788238 36637 89803376
Wound infection 27.92 10.11 1162 787272 105240 89734773
Hip fracture 27.77 10.11 171 788263 32906 89807107
Product use in unapproved indication 27.64 10.11 2533 785901 333703 89506310
Intentional dose omission 27.64 10.11 72 788362 17711 89822302
Aspergillus infection 27.62 10.11 32 788402 10791 89829222
Pneumonia 27.54 10.11 5009 783425 633050 89206963
Fixed eruption 27.52 10.11 52 788382 1678 89838335
Breast cancer stage I 27.32 10.11 26 788408 9598 89830415
Angina unstable 27.28 10.11 14 788420 7129 89832884
Hypertransaminasaemia 27.27 10.11 233 788201 15592 89824421
Pelvic pain 27.21 10.11 58 788376 15299 89824714
Blood parathyroid hormone decreased 27.19 10.11 40 788394 12176 89827837
Osteomyelitis 27.17 10.11 137 788297 27709 89812304
Drug ineffective for unapproved indication 27.05 10.11 412 788022 66232 89773781
Pharyngeal oedema 27.00 10.11 49 788385 13722 89826291
Dysphoria 26.76 10.11 10 788424 6144 89833869
Product administration interrupted 26.75 10.11 42 788392 12450 89827563
Product physical issue 26.70 10.11 8 788426 5652 89834361
Musculoskeletal stiffness 26.70 10.11 2959 785475 293573 89546440
Therapy partial responder 26.66 10.11 100 788334 21943 89818070
Embedded device 26.42 10.11 3 788431 4245 89835768
Pruritus 26.41 10.11 5217 783217 536308 89303705
Sleep disorder due to a general medical condition 26.39 10.11 255 788179 44483 89795530
Alanine aminotransferase increased 26.17 10.11 1270 787164 117068 89722945
Grip strength decreased 26.14 10.11 1019 787415 91557 89748456
Pregnancy with contraceptive device 26.11 10.11 6 788428 5060 89834953
Ventricular extrasystoles 26.11 10.11 47 788387 13203 89826810
Product label confusion 26.10 10.11 309 788125 22541 89817472
Haemophagocytic lymphohistiocytosis 26.06 10.11 60 788374 15399 89824614
Hypoacusis 26.06 10.11 139 788295 27711 89812302
Somnolence 26.06 10.11 2135 786299 206949 89633064
Vasoplegia syndrome 25.95 10.11 68 788366 2746 89837267
Large intestine polyp 25.90 10.11 26 788408 9360 89830653
Intervertebral disc protrusion 25.86 10.11 135 788299 27061 89812952
Mental impairment 25.76 10.11 68 788366 16652 89823361
Mood swings 25.64 10.11 93 788341 20609 89819404
Prescribed overdose 25.58 10.11 1066 787368 96559 89743454
Product quality issue 25.58 10.11 511 787923 78814 89761199
Chronic graft versus host disease 25.55 10.11 3 788431 4136 89835877
Abdominal pain upper 25.50 10.11 3286 785148 329388 89510625
Limb discomfort 25.50 10.11 210 788224 37850 89802163
Mood altered 25.45 10.11 71 788363 17073 89822940
Peripheral venous disease 25.44 10.11 931 787503 82990 89757023
Hepatitis cholestatic 25.42 10.11 144 788290 8417 89831596
Oral pain 25.38 10.11 173 788261 32510 89807503
Fear of injection 25.37 10.11 22 788412 8493 89831520
Hallucination, auditory 25.35 10.11 64 788370 15911 89824102
Head injury 25.27 10.11 163 788271 31025 89808988
Skin irritation 25.27 10.11 50 788384 13553 89826460
Rheumatoid lung 25.27 10.11 3 788431 4100 89835913
Nephrolithiasis 25.21 10.11 289 788145 48796 89791217
Galactorrhoea 25.17 10.11 5 788429 4667 89835346
Dysstasia 25.16 10.11 122 788312 24930 89815083
Acute respiratory failure 25.16 10.11 245 788189 42673 89797340
Mental disorder 25.13 10.11 171 788263 32147 89807866
Neutrophil percentage increased 25.12 10.11 70 788364 2933 89837080
Incorrect drug administration rate 25.12 10.11 101 788333 5122 89834891
Skin lesion 25.11 10.11 206 788228 37159 89802854
Live birth 25.06 10.11 882 787552 78225 89761788
Device leakage 25.01 10.11 30 788404 9961 89830052
Haematochezia 24.97 10.11 450 787984 70463 89769550
Paraesthesia ear 24.94 10.11 25 788409 432 89839581
Device deployment issue 24.93 10.11 6 788428 4903 89835110
Renal failure neonatal 24.93 10.11 18 788416 193 89839820
Skin cancer 24.85 10.11 50 788384 13469 89826544
Ovarian hyperstimulation syndrome 24.71 10.11 10 788424 5852 89834161
Serotonin syndrome 24.64 10.11 465 787969 37422 89802591
Extrapyramidal disorder 24.59 10.11 67 788367 16236 89823777
Loss of personal independence in daily activities 24.43 10.11 952 787482 135153 89704860
Disturbance in attention 24.33 10.11 277 788157 46832 89793181
Osteopenia 24.29 10.11 110 788324 22892 89817121
Chronic obstructive pulmonary disease 24.29 10.11 474 787960 73355 89766658
Temperature regulation disorder 24.26 10.11 213 788221 14366 89825647
Haematuria 24.22 10.11 191 788243 34746 89805267
Weight decreased 24.21 10.11 2914 785520 376996 89463017
Lymphoproliferative disorder 24.17 10.11 4 788430 4258 89835755
Arterial occlusive disease 24.01 10.11 188 788246 12258 89827755
Cystic fibrosis 23.98 10.11 3 788431 3938 89836075
Abnormal dreams 23.96 10.11 38 788396 11219 89828794
Low density lipoprotein increased 23.95 10.11 21 788413 8064 89831949
Infusion site haemorrhage 23.95 10.11 102 788332 5309 89834704
Systemic infection 23.93 10.11 6 788428 4769 89835244
Drug eruption 23.88 10.11 195 788239 35212 89804801
Neurologic neglect syndrome 23.81 10.11 145 788289 8702 89831311
Cryopyrin associated periodic syndrome 23.79 10.11 27 788407 541 89839472
Cardiotoxicity 23.72 10.11 39 788395 11350 89828663
Mania 23.67 10.11 55 788379 14069 89825944
Electrolyte imbalance 23.64 10.11 116 788318 23629 89816384
Finger deformity 23.59 10.11 410 788024 32487 89807526
Injury associated with device 23.59 10.11 5 788429 4459 89835554
Concomitant disease aggravated 23.47 10.11 40 788394 11478 89828535
Groin pain 23.46 10.11 44 788390 12169 89827844
Sputum culture positive 23.45 10.11 57 788377 2196 89837817
Gastritis 23.37 10.11 241 788193 41512 89798501
Vital capacity decreased 23.35 10.11 50 788384 1769 89838244
Blood immunoglobulin E increased 23.29 10.11 5 788429 4420 89835593
Endophthalmitis 23.26 10.11 6 788428 4679 89835334
Coagulation factor decreased 23.26 10.11 17 788417 186 89839827
Polycystic ovaries 23.26 10.11 10 788424 5644 89834369
X-ray abnormal 23.18 10.11 538 787896 44886 89795127
General physical health deterioration 23.10 10.11 3474 784960 351641 89488372
Withdrawal syndrome 23.03 10.11 109 788325 22415 89817598
Eye haemorrhage 22.99 10.11 33 788401 10147 89829866
Enthesopathy 22.74 10.11 29 788405 9375 89830638
Acidosis 22.74 10.11 189 788245 12547 89827466
Tendonitis 22.69 10.11 102 788332 21270 89818743
Physical deconditioning 22.68 10.11 56 788378 2179 89837834
Arrhythmia 22.62 10.11 247 788187 42085 89797928
Fluid retention 22.60 10.11 588 787846 87503 89752510
Blood creatine increased 22.58 10.11 120 788314 6847 89833166
Lymphadenopathy 22.55 10.11 272 788162 45503 89794510
Medication overuse headache 22.51 10.11 44 788390 1457 89838556
Bone disorder 22.41 10.11 114 788320 23006 89817007
Gangrene 22.41 10.11 190 788244 12686 89827327
Infusion site mass 22.38 10.11 55 788379 2134 89837879
Invasive ductal breast carcinoma 22.34 10.11 21 788413 7797 89832216
Aggression 22.32 10.11 138 788296 26530 89813483
Hypervolaemia 22.28 10.11 180 788254 32577 89807436
Renal papillary necrosis 22.23 10.11 19 788415 265 89839748
Pancreatic carcinoma 22.22 10.11 24 788410 8353 89831660
Spinal operation 22.10 10.11 34 788400 10162 89829851
Drug interaction 22.09 10.11 2087 786347 274366 89565647
Visual impairment 22.01 10.11 934 787500 131431 89708582
Hepatitis B reactivation 21.95 10.11 4 788430 3970 89836043
International normalised ratio increased 21.91 10.11 553 787881 46763 89793250
Personality disorder 21.86 10.11 184 788250 12260 89827753
Supraventricular tachycardia 21.85 10.11 71 788363 16265 89823748
C-reactive protein 21.81 10.11 389 788045 30978 89809035
Blood pH decreased 21.77 10.11 60 788374 2498 89837515
Oral discomfort 21.74 10.11 36 788398 10447 89829566
C-reactive protein abnormal 21.72 10.11 1335 787099 126094 89713919
Rebound effect 21.61 10.11 30 788404 9354 89830659
Bundle branch block left 21.58 10.11 22 788412 7863 89832150
Tricuspid valve incompetence 21.50 10.11 74 788360 16657 89823356
Soft tissue disorder 21.47 10.11 84 788350 4206 89835807
Uterine cancer 21.41 10.11 10 788424 5375 89834638
Panniculitis 21.37 10.11 60 788374 14398 89825615
Hiatus hernia 21.35 10.11 131 788303 25230 89814783
Shoulder arthroplasty 21.34 10.11 5 788429 4161 89835852
Hepatic function abnormal 21.32 10.11 279 788155 46009 89794004
Macular oedema 21.31 10.11 8 788426 4901 89835112
Cough 21.29 10.11 2848 785586 366114 89473899
Deafness 21.27 10.11 112 788322 22402 89817611
Lymphoma 21.15 10.11 55 788379 13536 89826477
Polyarthritis 21.07 10.11 85 788349 18265 89821748
Gastrointestinal pain 20.98 10.11 41 788393 11165 89828848
Granuloma skin 20.94 10.11 38 788396 10642 89829371
Left ventricular dysfunction 20.86 10.11 62 788372 14607 89825406
Cardiovascular disorder 20.69 10.11 55 788379 13437 89826576
Asthma-chronic obstructive pulmonary disease overlap syndrome 20.65 10.11 91 788343 4808 89835205
Lymphocyte percentage decreased 20.59 10.11 67 788367 3060 89836953
Spinal osteoarthritis 20.56 10.11 91 788343 19057 89820956
Sciatica 20.55 10.11 1079 787355 100303 89739710
Administration site pain 20.50 10.11 37 788397 1152 89838861
Joint destruction 20.50 10.11 54 788380 13233 89826780
Acute graft versus host disease 20.46 10.11 11 788423 5457 89834556
Product residue present 20.36 10.11 6 788428 4285 89835728
Diplopia 20.36 10.11 156 788278 28558 89811455
Spinal compression fracture 20.28 10.11 66 788368 15112 89824901
Red blood cells urine positive 20.26 10.11 68 788366 3157 89836856
Bezoar 20.24 10.11 61 788373 2673 89837340
Total lung capacity increased 20.21 10.11 92 788342 4929 89835084
Ocular hyperaemia 20.21 10.11 192 788242 33606 89806407
Epstein-Barr virus infection 20.11 10.11 37 788397 10307 89829706
Arteriosclerosis 20.07 10.11 40 788394 10813 89829200
Ischaemic stroke 19.99 10.11 112 788322 22054 89817959
Breast cancer stage III 19.88 10.11 912 787522 83535 89756478
Tumour marker increased 19.87 10.11 13 788421 5794 89834219
Intracranial pressure increased 19.85 10.11 114 788320 6697 89833316
Intestinal haemorrhage 19.72 10.11 7 788427 4440 89835573
Osmolar gap 19.71 10.11 12 788422 94 89839919
Brain stem glioma 19.67 10.11 15 788419 176 89839837
Granuloma 19.65 10.11 15 788419 6170 89833843
Asthma 19.64 10.11 1826 786608 240334 89599679
Carotid artery thrombosis 19.61 10.11 141 788293 8951 89831062
Back pain 19.54 10.11 2438 785996 314737 89525276
Hepatic cyst 19.53 10.11 17 788417 6551 89833462
Ventricular fibrillation 19.51 10.11 60 788374 13984 89826029
Emotional disorder 19.49 10.11 66 788368 14931 89825082
Multiple organ dysfunction syndrome 19.48 10.11 449 787985 67887 89772126
Knee operation 19.39 10.11 19 788415 6917 89833096
Liver transplant 19.37 10.11 54 788380 2263 89837750
Stress fracture 19.36 10.11 28 788406 8583 89831430
Colorectal cancer 19.30 10.11 5 788429 3888 89836125
Skin disorder 19.29 10.11 215 788219 36491 89803522
Device related infection 19.29 10.11 138 788296 25648 89814365
Uterine leiomyoma 19.27 10.11 41 788393 10823 89829190
Bradypnoea 19.24 10.11 86 788348 4572 89835441
Varicella zoster virus infection 19.18 10.11 5 788429 3872 89836141
Tooth extraction 19.16 10.11 45 788389 11468 89828545
Device failure 19.15 10.11 19 788415 6878 89833135
Transaminases increased 19.13 10.11 441 787993 36751 89803262
Intervertebral discitis 19.08 10.11 84 788350 4436 89835577
Caesarean section 18.93 10.11 90 788344 18487 89821526
Glucose tolerance impaired 18.92 10.11 25 788409 7960 89832053
Specific gravity urine abnormal 18.85 10.11 11 788423 79 89839934
Lactic acidosis 18.80 10.11 317 788117 50146 89789867
Mucormycosis 18.77 10.11 5 788429 3816 89836197
Cytomegalovirus viraemia 18.75 10.11 23 788411 7563 89832450
Wrong technique in device usage process 18.73 10.11 14 788420 5821 89834192
Vertigo 18.71 10.11 463 787971 69348 89770665
Hysterectomy 18.70 10.11 46 788388 11538 89828475
Aortic valve incompetence 18.68 10.11 18 788416 6606 89833407
Blood bilirubin increased 18.66 10.11 503 787931 42967 89797046
Atypical femur fracture 18.64 10.11 17 788417 6404 89833609
Adjustment disorder with depressed mood 18.53 10.11 635 787799 56118 89783895
Diffuse large B-cell lymphoma recurrent 18.53 10.11 4 788430 3522 89836491
Congestive cardiomyopathy 18.49 10.11 22 788412 7332 89832681
Coagulation factor X level decreased 18.46 10.11 10 788424 61 89839952
Skin toxicity 18.46 10.11 19 788415 6760 89833253
Thyroid neoplasm 18.40 10.11 6 788428 4015 89835998
Toxicologic test abnormal 18.37 10.11 27 788407 705 89839308
Infusion site nodule 18.37 10.11 44 788390 1679 89838334
Reversible airways obstruction 18.37 10.11 48 788386 1935 89838078
Antidepressant drug level above therapeutic 18.37 10.11 22 788412 468 89839545
Ankle fracture 18.33 10.11 103 788331 20267 89819746
Personality change 18.31 10.11 22 788412 7299 89832714
Device defective 18.22 10.11 4 788430 3482 89836531
Dislocation of vertebra 18.22 10.11 626 787808 55342 89784671
Central nervous system lesion 18.22 10.11 47 788387 11599 89828414
Glomerular filtration rate increased 18.21 10.11 49 788385 2011 89838002
Amniotic cavity disorder 18.20 10.11 10 788424 63 89839950
Injection site discomfort 18.12 10.11 15 788419 5925 89834088
Metabolic disorder 18.10 10.11 23 788411 7447 89832566
Intervertebral disc degeneration 18.01 10.11 83 788351 17191 89822822
Total lung capacity decreased 17.94 10.11 73 788361 3722 89836291
Neuroblastoma recurrent 17.89 10.11 14 788420 171 89839842
Nasal necrosis 17.81 10.11 12 788422 114 89839899
Abdominal pain lower 17.80 10.11 172 788262 30005 89810008
Gastrooesophageal reflux disease 17.68 10.11 1227 787207 165110 89674903
Needle issue 17.65 10.11 62 788372 13872 89826141
Laboratory test abnormal 17.59 10.11 257 788177 41597 89798416
Bone lesion 17.57 10.11 18 788416 6419 89833594
Hypertension 17.56 10.11 4359 784075 453173 89386840
Cardiac failure chronic 17.55 10.11 14 788420 5632 89834381
Gastroenteritis 17.50 10.11 166 788268 29063 89810950
Sexual dysfunction 17.49 10.11 10 788424 4794 89835219
Somnambulism 17.48 10.11 17 788417 6211 89833802
Bronchopulmonary aspergillosis allergic 17.46 10.11 72 788362 3694 89836319
Anger 17.41 10.11 61 788373 13659 89826354
Gastrointestinal toxicity 17.41 10.11 35 788399 9432 89830581
Hypertriglyceridaemia 17.40 10.11 26 788408 7863 89832150
Accidental death 17.39 10.11 48 788386 2000 89838013
Blood loss anaemia 17.38 10.11 39 788395 10101 89829912
Nervousness 17.30 10.11 201 788233 33855 89806158
Metastases to central nervous system 17.29 10.11 86 788348 17456 89822557
Clostridium difficile infection 17.24 10.11 217 788217 36028 89803985
Herpes zoster 17.20 10.11 661 787773 93983 89746030
Acute graft versus host disease in skin 17.18 10.11 10 788424 4746 89835267
Coordination abnormal 17.10 10.11 271 788163 21085 89818928
Injection site haematoma 17.10 10.11 21 788413 6901 89833112
Abortion induced 17.08 10.11 50 788384 11838 89828175
Body temperature fluctuation 17.07 10.11 51 788383 2224 89837789
Administration site bruise 17.06 10.11 21 788413 460 89839553
Paradoxical drug reaction 17.06 10.11 15 788419 5751 89834262
Harlequin syndrome 17.05 10.11 15 788419 218 89839795
Intraocular pressure increased 17.02 10.11 22 788412 7071 89832942
Panic attack 16.97 10.11 147 788287 26218 89813795
Generalised tonic-clonic seizure 16.96 10.11 208 788226 34695 89805318
Blood triglycerides increased 16.92 10.11 62 788372 13699 89826314
Cytomegalovirus infection reactivation 16.92 10.11 26 788408 7774 89832239
Movement disorder 16.87 10.11 166 788268 28853 89811160
Snoring 16.84 10.11 12 788422 5114 89834899
Disorientation 16.80 10.11 276 788158 43838 89796175
Lung infiltration 16.79 10.11 72 788362 15210 89824803
Onychomycosis 16.77 10.11 435 787999 36941 89803072
Injection site nodule 16.74 10.11 9 788425 4464 89835549
Urinary incontinence 16.73 10.11 228 788206 37338 89802675
Thyroid cancer 16.67 10.11 18 788416 6266 89833747
Body height decreased 16.64 10.11 51 788383 11898 89828115
Rheumatoid nodule 16.54 10.11 105 788329 20061 89819952
Transplant dysfunction 16.54 10.11 13 788421 5269 89834744
Encephalopathy 16.54 10.11 525 787909 45919 89794094
Hypoglycaemic coma 16.53 10.11 3 788431 2987 89837026
Toxic epidermal necrolysis 16.52 10.11 385 788049 32143 89807870
Cholecystectomy 16.49 10.11 50 788384 11705 89828308
Anhedonia 16.48 10.11 48 788386 11383 89828630
Dermatitis allergic 16.48 10.11 86 788348 17241 89822772
Gout 16.42 10.11 83 788351 16776 89823237
Squamous cell carcinoma 16.40 10.11 40 788394 10061 89829952
Onychomadesis 16.39 10.11 520 787914 45478 89794535
Injection site vesicles 16.39 10.11 8 788426 4192 89835821
Bronchopulmonary aspergillosis 16.34 10.11 48 788386 11350 89828663
Neoplasm 16.30 10.11 33 788401 8870 89831143
Coagulation factor VII level decreased 16.26 10.11 10 788424 80 89839933
Ventricular tachycardia 16.25 10.11 137 788297 24571 89815442
Secretion discharge 16.21 10.11 77 788357 15819 89824194
Metastases to lymph nodes 16.20 10.11 50 788384 11639 89828374
Acne 16.18 10.11 164 788270 28343 89811670
Papule 16.11 10.11 28 788406 7974 89832039
Sensory disturbance 16.10 10.11 74 788360 15339 89824674
Delirium 16.09 10.11 1084 787350 103275 89736738
Nail bed inflammation 16.08 10.11 43 788391 1758 89838255
Expired product administered 16.07 10.11 22 788412 6900 89833113
Maternal exposure timing unspecified 16.05 10.11 280 788154 22203 89817810
Hypophagia 16.04 10.11 218 788216 35719 89804294
Red blood cell count decreased 16.04 10.11 295 788139 46056 89793957
Liver disorder 16.02 10.11 1244 787190 120025 89719988
Ketoacidosis 16.02 10.11 15 788419 5580 89834433
Pneumonia aspiration 15.97 10.11 255 788179 40685 89799328
Peritonitis 15.96 10.11 103 788331 19602 89820411
Human herpesvirus 6 infection 15.92 10.11 5 788429 3427 89836586
Myopathy 15.91 10.11 62 788372 13456 89826557
Malignant melanoma 15.90 10.11 56 788378 12520 89827493
Blood glucose abnormal 15.87 10.11 37 788397 9455 89830558
Systemic candida 15.79 10.11 12 788422 4947 89835066
Hyperthyroidism 15.71 10.11 94 788340 18216 89821797
Endocarditis enterococcal 15.69 10.11 15 788419 244 89839769
Nutritional supplementation 15.58 10.11 8 788426 43 89839970
Pollakiuria 15.55 10.11 198 788236 32807 89807206
Abnormal loss of weight 15.52 10.11 22 788412 6801 89833212
Sinus rhythm 15.44 10.11 36 788398 1350 89838663
Thirst 15.43 10.11 81 788353 16214 89823799
Mydriasis 15.42 10.11 199 788235 14813 89825200
Infusion site urticaria 15.37 10.11 41 788393 1674 89838339
Frostbite 15.34 10.11 14 788420 214 89839799
Muscle disorder 15.32 10.11 15 788419 5464 89834549
Respiratory symptom 15.27 10.11 9 788425 4243 89835770
Potentiating drug interaction 15.27 10.11 16 788418 5646 89834367
Leukoencephalopathy 15.25 10.11 12 788422 4861 89835152
Hemivertebra 15.23 10.11 11 788423 118 89839895
Eyelid ptosis 15.15 10.11 35 788399 8971 89831042
Injection site irritation 15.12 10.11 18 788416 5997 89834016
Dry mouth 15.12 10.11 1826 786608 182233 89657780
Underdose 15.09 10.11 356 788078 53661 89786352
Adjustment disorder 15.09 10.11 139 788295 9503 89830510
Acute generalised exanthematous pustulosis 15.08 10.11 184 788250 13519 89826494
Drug provocation test 15.06 10.11 7 788427 29 89839984
Hyperprolactinaemia 15.05 10.11 15 788419 5418 89834595
Haemarthrosis 15.00 10.11 8 788426 3986 89836027
Foreign body sensation in eyes 14.97 10.11 5 788429 3295 89836718
Glycosylated haemoglobin increased 14.93 10.11 77 788357 15485 89824528
Extra dose administered 14.88 10.11 36 788398 9082 89830931
Application site erythema 14.87 10.11 14 788420 5194 89834819
SJS-TEN overlap 14.85 10.11 31 788403 1077 89838936
Graft versus host disease in gastrointestinal tract 14.78 10.11 10 788424 4378 89835635
Ataxia 14.77 10.11 94 788340 17948 89822065
Retinal haemorrhage 14.76 10.11 17 788417 5747 89834266
Cardiac operation 14.70 10.11 8 788426 3941 89836072
Anxiety 14.68 10.11 2419 786015 307353 89532660
Impaired work ability 14.66 10.11 103 788331 19223 89820790
Hypersensitivity vasculitis 14.66 10.11 9 788425 4150 89835863
Metastases to peritoneum 14.63 10.11 9 788425 4146 89835867
Intestinal obstruction 14.57 10.11 231 788203 36900 89803113
Erysipelas 14.57 10.11 36 788398 9016 89830997
Catheterisation cardiac 14.53 10.11 13 788421 4943 89835070
Nervous system disorder 14.53 10.11 119 788315 21474 89818539
Nephrotic syndrome 14.49 10.11 26 788408 7313 89832700
Pulmonary arterial pressure increased 14.48 10.11 8 788426 3908 89836105
Product monitoring error 14.46 10.11 11 788423 4533 89835480
Lupus vulgaris 14.42 10.11 503 787931 44556 89795457
Anuria 14.40 10.11 73 788361 14745 89825268
Cystitis haemorrhagic 14.40 10.11 16 788418 5497 89834516
Breast cancer recurrent 14.34 10.11 16 788418 5487 89834526
Catatonia 14.31 10.11 19 788415 6037 89833976
Ovarian cyst 14.29 10.11 90 788344 17228 89822785
Inappropriate antidiuretic hormone secretion 14.29 10.11 105 788329 19400 89820613
Adrenal insufficiency 14.28 10.11 179 788255 29742 89810271
Therapy change 14.27 10.11 32 788402 8290 89831723
Mycobacterium avium complex infection 14.26 10.11 9 788425 4089 89835924
Accidental poisoning 14.23 10.11 28 788406 932 89839081
Diverticulum intestinal 14.22 10.11 37 788397 9105 89830908
Abnormal behaviour 14.20 10.11 127 788307 22501 89817512
Rash macular 14.13 10.11 182 788252 30098 89809915
Torsade de pointes 14.08 10.11 76 788358 15106 89824907
Immunosuppressant drug level increased 14.06 10.11 12 788422 4668 89835345
Product dispensing error 14.00 10.11 57 788377 12216 89827797
Oropharyngeal discomfort 13.92 10.11 115 788319 7620 89832393
Blindness unilateral 13.89 10.11 29 788405 7707 89832306
Focal dyscognitive seizures 13.86 10.11 5 788429 3139 89836874
Aortic valve stenosis 13.83 10.11 10 788424 4230 89835783
Cerebral ischaemia 13.76 10.11 26 788408 7170 89832843
Essential hypertension 13.74 10.11 21 788413 6294 89833719
Nerve injury 13.68 10.11 50 788384 11056 89828957
Transfusion-related acute lung injury 13.66 10.11 12 788422 174 89839839
Nasal obstruction 13.65 10.11 3 788431 2609 89837404
Aplasia pure red cell 13.65 10.11 15 788419 5179 89834834
Status epilepticus 13.64 10.11 102 788332 18772 89821241
Stent placement 13.60 10.11 10 788424 4193 89835820
Klebsiella infection 13.60 10.11 45 788389 10252 89829761
Cyanosis neonatal 13.60 10.11 18 788416 425 89839588
Premature rupture of membranes 13.58 10.11 17 788417 5541 89834472
Diastolic dysfunction 13.58 10.11 27 788407 7306 89832707
Malnutrition 13.55 10.11 100 788334 18458 89821555
Laryngospasm 13.54 10.11 6 788428 3327 89836686
Rotator cuff syndrome 13.52 10.11 82 788352 15837 89824176
Lymphocyte count decreased 13.49 10.11 400 788034 34650 89805363
Macular degeneration 13.46 10.11 429 788005 37541 89802472
Stress cardiomyopathy 13.43 10.11 65 788369 13290 89826723
Acute fatty liver of pregnancy 13.43 10.11 7 788427 39 89839974
Coronary arterial stent insertion 13.42 10.11 4 788430 2836 89837177
Post cholecystectomy syndrome 13.42 10.11 26 788408 855 89839158
Graft versus host disease 13.42 10.11 32 788402 8112 89831901
Hepatitis 13.37 10.11 748 787686 69991 89770022
Nocardiosis 13.33 10.11 3 788431 2567 89837446
Bruxism 13.33 10.11 11 788423 4352 89835661
Anosognosia 13.31 10.11 7 788427 3515 89836498
Hyperphagia 13.26 10.11 4 788430 2814 89837199
Bacterial test 13.25 10.11 30 788404 1103 89838910
Drooling 13.24 10.11 12 788422 4534 89835479
Blood glucose decreased 13.21 10.11 135 788299 23294 89816719
Post procedural pulmonary embolism 13.19 10.11 13 788421 220 89839793
Cells in urine 13.17 10.11 12 788422 183 89839830
Neonatal respiratory acidosis 13.17 10.11 14 788420 260 89839753
Crying 13.16 10.11 151 788283 25494 89814519
Coagulation factor V level decreased 13.16 10.11 16 788418 346 89839667
Alpha 1 microglobulin increased 13.15 10.11 7 788427 41 89839972
Foot fracture 13.14 10.11 158 788276 26448 89813565
Vitamin D deficiency 13.11 10.11 94 788340 17462 89822551
Haemoglobin urine present 13.06 10.11 24 788410 758 89839255
Occupational exposure to product 13.04 10.11 3 788431 2528 89837485
Neoplasm recurrence 13.04 10.11 6 788428 3253 89836760
Cachexia 13.02 10.11 25 788409 6853 89833160
Foetal heart rate abnormal 12.99 10.11 27 788407 935 89839078
Delusion 12.99 10.11 69 788365 13771 89826242
Dysphagia 12.98 10.11 822 787612 111456 89728557
Self-medication 12.96 10.11 59 788375 3161 89836852
Infusion site discomfort 12.96 10.11 40 788394 1776 89838237
BK virus infection 12.95 10.11 12 788422 4486 89835527
Substance abuse 12.94 10.11 86 788348 5320 89834693
Arthrodesis 12.92 10.11 5 788429 3007 89837006
Hair texture abnormal 12.92 10.11 13 788421 4674 89835339
Aplastic anaemia 12.84 10.11 174 788260 13095 89826918
Maternal exposure before pregnancy 12.84 10.11 52 788382 11161 89828852
Proteinuria 12.81 10.11 135 788299 23156 89816857
Pre-eclampsia 12.80 10.11 51 788383 10997 89829016
Necrotic lymphadenopathy 12.79 10.11 10 788424 122 89839891
Infusion site irritation 12.79 10.11 33 788401 1320 89838693
Inappropriate schedule of product administration 12.78 10.11 1491 786943 148442 89691571
Sinus node dysfunction 12.77 10.11 17 788417 5395 89834618
Bipolar disorder 12.76 10.11 38 788396 8947 89831066
Orbital compartment syndrome 12.74 10.11 9 788425 93 89839920
Polyomavirus-associated nephropathy 12.73 10.11 3 788431 2487 89837526
Blindness 12.66 10.11 159 788275 26409 89813604
Blood prolactin increased 12.64 10.11 8 788426 3629 89836384
Nephropathy toxic 12.62 10.11 62 788372 12626 89827387
Pelvic fracture 12.61 10.11 79 788355 15140 89824873
Incontinence 12.60 10.11 67 788367 13368 89826645
Dystonia 12.58 10.11 90 788344 16729 89823284
Haematemesis 12.52 10.11 212 788222 33514 89806499
Catheter site bruise 12.49 10.11 20 788414 564 89839449
Goitre 12.46 10.11 25 788409 6742 89833271
Aneurysm 12.40 10.11 8 788426 3592 89836421
Eye pain 12.37 10.11 291 788143 43877 89796136
Abdominal distension 12.34 10.11 973 787461 129628 89710385
Paranoia 12.31 10.11 64 788370 12844 89827169
Colon gangrene 12.28 10.11 4 788430 4 89840009
Exposure to SARS-CoV-2 12.26 10.11 48 788386 2404 89837609
Jaw fracture 12.25 10.11 4 788430 2674 89837339
Gastric cancer 12.25 10.11 16 788418 5120 89834893
Constipation 12.18 10.11 2200 786234 278195 89561818
Epstein-Barr virus associated lymphoproliferative disorder 12.17 10.11 4 788430 2663 89837350
Costovertebral angle tenderness 12.17 10.11 11 788423 166 89839847
Diverticulum 12.16 10.11 59 788375 12054 89827959
Asthenia 12.12 10.11 4313 784121 529438 89310575
Thoracic vertebral fracture 12.11 10.11 18 788416 5456 89834557
Pulmonary alveolar haemorrhage 12.07 10.11 21 788413 5977 89834036
Hot flush 12.04 10.11 410 788024 59078 89780935
Neurological examination normal 12.03 10.11 7 788427 50 89839963
Candida infection 12.02 10.11 216 788218 33841 89806172
Bladder cancer 11.96 10.11 20 788414 5781 89834232
Hepatitis B 11.93 10.11 13 788421 4506 89835507
Drug tolerance decreased 11.92 10.11 365 788069 31765 89808248
Haemorrhoids 11.91 10.11 162 788272 26540 89813473
Increased tendency to bruise 11.89 10.11 58 788376 11832 89828181
Illness 11.88 10.11 587 787847 81382 89758631
Glutathione decreased 11.87 10.11 6 788428 31 89839982
Hip arthroplasty 11.82 10.11 792 787642 75416 89764597
Cardiogenic shock 11.82 10.11 146 788288 24322 89815691
Base excess 11.80 10.11 7 788427 52 89839961
Nephrogenic systemic fibrosis 11.78 10.11 11 788423 4097 89835916
Affective disorder 11.77 10.11 32 788402 7761 89832252
Diverticulitis 11.76 10.11 301 788133 44886 89795127
Skin swelling 11.70 10.11 25 788409 6589 89833424
Skin fissures 11.69 10.11 120 788314 20689 89819324
Drug screen positive 11.69 10.11 64 788370 3693 89836320
Lung opacity 11.68 10.11 92 788342 6010 89834003
Lung transplant 11.67 10.11 9 788425 3683 89836330
Creatinine renal clearance increased 11.67 10.11 58 788376 3223 89836790
Restless legs syndrome 11.65 10.11 132 788302 22338 89817675
Peptic ulcer perforation 11.65 10.11 17 788417 441 89839572
Hereditary angioedema 11.64 10.11 42 788392 9323 89830690
Lung adenocarcinoma 11.64 10.11 19 788415 5546 89834467
Band neutrophil percentage increased 11.63 10.11 12 788422 215 89839798
Band neutrophil count increased 11.61 10.11 16 788418 393 89839620
Jaw disorder 11.61 10.11 19 788415 5540 89834473
Pulmonary tuberculosis 11.59 10.11 15 788419 4819 89835194
Haemolysis 11.51 10.11 119 788315 8391 89831622
Dysuria 11.48 10.11 258 788176 39143 89800870
Onychoclasis 11.47 10.11 30 788404 7369 89832644
Application site pruritus 11.45 10.11 12 788422 4235 89835778
Ejection fraction decreased 11.45 10.11 160 788274 26093 89813920
Skin weeping 11.44 10.11 5 788429 2795 89837218
Urinary casts 11.41 10.11 23 788411 779 89839234
Pneumothorax 11.41 10.11 109 788325 19058 89820955
Akathisia 11.41 10.11 54 788380 11105 89828908
Agonal respiration 11.40 10.11 11 788423 181 89839832
Myelocyte count increased 11.40 10.11 16 788418 400 89839613
Carotid artery stenosis 11.36 10.11 18 788416 5316 89834697
Hepatitis toxic 11.29 10.11 63 788371 3662 89836351
Pneumonitis 11.28 10.11 295 788139 43875 89796138
Prothrombin level decreased 11.22 10.11 21 788413 673 89839340
Blood urine present 11.22 10.11 212 788222 17066 89822947
Colon cancer 11.16 10.11 53 788381 10891 89829122
Granulocyte count increased 11.14 10.11 34 788400 1500 89838513
Anti-cyclic citrullinated peptide antibody 11.12 10.11 313 788121 26908 89813105
Prothrombin time prolonged 11.09 10.11 132 788302 9640 89830373
Haemorrhage subcutaneous 11.09 10.11 8 788426 3388 89836625
Unresponsive to stimuli 11.09 10.11 421 788013 37700 89802313
Gingival disorder 11.08 10.11 11 788423 3980 89836033
Congestive hepatopathy 11.06 10.11 54 788380 2979 89837034
Walking aid user 11.03 10.11 395 788039 35111 89804902
Musculoskeletal discomfort 11.01 10.11 123 788311 20868 89819145
Sickle cell anaemia with crisis 11.00 10.11 30 788404 7267 89832746
Stoma site dermatitis 10.98 10.11 13 788421 273 89839740
Antipsychotic drug level increased 10.98 10.11 10 788424 3769 89836244
Lymphadenopathy mediastinal 10.96 10.11 7 788427 3160 89836853
Supraventricular extrasystoles 10.95 10.11 18 788416 5239 89834774
Pathological fracture 10.93 10.11 45 788389 9615 89830398
Eosinophil percentage increased 10.93 10.11 26 788408 988 89839025
Metabolic myopathy 10.92 10.11 9 788425 119 89839894
Renal cancer 10.92 10.11 22 788412 5923 89834090
Granulocytopenia 10.86 10.11 25 788409 6416 89833597
Tachyarrhythmia 10.81 10.11 19 788415 5387 89834626
Hepatic perfusion disorder 10.79 10.11 7 788427 62 89839951
Postmortem blood drug level increased 10.77 10.11 21 788413 694 89839319
Metastases to spine 10.76 10.11 10 788424 3733 89836280
Infusion site discolouration 10.75 10.11 27 788407 1062 89838951
Blood creatinine decreased 10.75 10.11 95 788339 6420 89833593
White coat hypertension 10.74 10.11 26 788408 999 89839014
Oesophagitis 10.74 10.11 97 788337 17152 89822861
Foetal exposure during pregnancy 10.72 10.11 288 788146 42687 89797326
Miosis 10.72 10.11 128 788306 9356 89830657
Kidney transplant rejection 10.72 10.11 16 788418 4841 89835172
Non-cardiogenic pulmonary oedema 10.70 10.11 29 788405 1195 89838818
Diffuse axonal injury 10.69 10.11 8 788426 91 89839922
Tuberculin test positive 10.65 10.11 10 788424 3715 89836298
Subdural haematoma 10.63 10.11 93 788341 16552 89823461
Internal haemorrhage 10.60 10.11 24 788410 6196 89833817
Disseminated intravascular coagulation 10.60 10.11 128 788306 21410 89818603
Gingival hypertrophy 10.58 10.11 3 788431 2197 89837816
Coma hepatic 10.57 10.11 20 788414 646 89839367
Administration site erythema 10.55 10.11 24 788410 885 89839128
Vitamin D decreased 10.55 10.11 61 788373 11918 89828095
Application site rash 10.54 10.11 5 788429 2664 89837349
Nasal ulcer 10.52 10.11 5 788429 2661 89837352
Leukaemia 10.49 10.11 17 788417 4975 89835038
Disseminated tuberculosis 10.48 10.11 8 788426 3291 89836722
Transferrin decreased 10.45 10.11 15 788419 383 89839630
Mean cell haemoglobin concentration increased 10.43 10.11 19 788415 596 89839417
Asphyxia 10.42 10.11 101 788333 7002 89833011
Peripheral arterial occlusive disease 10.41 10.11 15 788419 4606 89835407
Vitamin K deficiency 10.40 10.11 17 788417 488 89839525
Hypotonic-hyporesponsive episode 10.35 10.11 5 788429 23 89839990
Catheter site discharge 10.33 10.11 4 788430 2405 89837608
Regurgitation 10.33 10.11 3 788431 2163 89837850
Ileus 10.32 10.11 93 788341 16453 89823560
Wheelchair user 10.30 10.11 34 788400 7751 89832262
Arterial intramural haematoma 10.30 10.11 10 788424 166 89839847
Dyslipidaemia 10.28 10.11 49 788385 10058 89829955
Carbohydrate antigen 125 increased 10.27 10.11 8 788426 3258 89836755
Tongue disorder 10.27 10.11 54 788380 10806 89829207
Nocturia 10.27 10.11 50 788384 10205 89829808
Blepharospasm 10.23 10.11 585 787849 54860 89785153
Vomiting 10.22 10.11 7234 781200 781059 89058954
Eye swelling 10.18 10.11 187 788247 29199 89810814
Ankle arthroplasty 10.16 10.11 6 788428 2825 89837188
Implant site pain 10.15 10.11 5 788429 2607 89837406
Sluggishness 10.15 10.11 23 788411 5936 89834077
Metastases to skin 10.14 10.11 3 788431 2137 89837876
Patent ductus arteriosus 10.13 10.11 15 788419 4554 89835459
Fear 10.12 10.11 94 788340 16528 89823485
Anticholinergic syndrome 10.12 10.11 49 788385 2694 89837319
Catheter management 10.12 10.11 7 788427 3029 89836984

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2401.40 10.96 4650 251916 224486 42140283
Completed suicide 1666.07 10.96 2451 254115 94014 42270755
Exposure to toxic agent 1273.87 10.96 616 255950 4388 42360381
Intentional overdose 772.06 10.96 1226 255340 50230 42314539
Overdose 680.26 10.96 1766 254800 103498 42261271
Acute hepatic failure 622.90 10.96 634 255932 16439 42348330
Infusion related reaction 479.67 10.96 1102 255464 59704 42305065
Intentional product misuse 463.33 10.96 1099 255467 60801 42303968
Blood pressure fluctuation 425.41 10.96 657 255909 26251 42338518
Hepatic cytolysis 411.23 10.96 646 255920 26198 42338571
Drug ineffective 331.08 10.96 2332 254234 627865 41736904
Suicide attempt 321.88 10.96 797 255769 45303 42319466
Cytokine release syndrome 305.81 10.96 765 255801 43762 42321007
Metabolic acidosis 248.72 10.96 782 255784 51076 42313693
Heart rate decreased 220.41 10.96 598 255968 35934 42328835
Analgesic drug level increased 213.46 10.96 113 256453 995 42363774
Poisoning deliberate 212.37 10.96 283 256283 9851 42354918
Suspected suicide 209.48 10.96 221 256345 5978 42358791
Drug abuse 171.43 10.96 1149 255417 103622 42261147
Medication error 170.14 10.96 512 256054 32642 42332127
Pyroglutamic acidosis 165.36 10.96 85 256481 700 42364069
Febrile neutropenia 162.58 10.96 1771 254795 183932 42180837
Myocardial infarction 158.35 10.96 317 256249 123692 42241077
Blood pressure increased 151.52 10.96 1092 255474 100836 42263933
Accidental overdose 146.77 10.96 439 256127 27891 42336878
Liver injury 136.70 10.96 334 256232 18814 42345955
Intentional product use issue 127.34 10.96 804 255762 71029 42293740
Cardiac failure congestive 126.21 10.96 200 256366 85402 42279367
Coagulopathy 124.97 10.96 354 256212 21808 42342961
Drug resistance 124.34 10.96 27 256539 34221 42330548
Product dose omission issue 124.11 10.96 493 256073 153872 42210897
Blood pressure systolic increased 120.74 10.96 407 256159 27561 42337208
Poisoning 118.65 10.96 269 256297 14430 42350339
Diarrhoea 113.79 10.96 2022 254544 458827 41905942
Myelosuppression 112.89 10.96 51 256515 40410 42324359
Suspected suicide attempt 112.34 10.96 52 256514 331 42364438
Oxygen saturation decreased 112.16 10.96 720 255846 63967 42300802
Injection site pain 111.37 10.96 110 256456 57688 42307081
Inspiratory capacity decreased 106.03 10.96 109 256457 2858 42361911
Anion gap 104.00 10.96 64 256502 769 42364000
Blood pressure diastolic abnormal 95.92 10.96 149 256417 5979 42358790
Treatment failure 94.50 10.96 144 256422 62480 42302289
Hepatitis fulminant 91.14 10.96 130 256436 4829 42359940
Therapeutic product effect incomplete 90.79 10.96 181 256385 70758 42294011
Fixed eruption 89.23 10.96 91 256475 2363 42362406
Hepatotoxicity 85.61 10.96 339 256227 24828 42339941
Toxic epidermal necrolysis 82.05 10.96 349 256217 26401 42338368
Chills 81.64 10.96 896 255670 93170 42271599
Coma 80.22 10.96 575 255991 52979 42311790
COVID-19 77.41 10.96 1051 255515 114897 42249872
Cardiac failure 76.20 10.96 357 256209 106499 42258270
Hepatitis acute 73.27 10.96 165 256401 8810 42355959
Cardio-respiratory arrest 72.48 10.96 602 255964 58034 42306735
Body temperature decreased 71.50 10.96 220 256346 14193 42350576
Methaemoglobinaemia 71.05 10.96 126 256440 5648 42359121
Tachycardia 68.58 10.96 919 255647 100168 42264601
Respiratory depression 67.30 10.96 258 256308 18610 42346159
Blood pressure diastolic increased 66.58 10.96 130 256436 6275 42358494
Vomiting 66.40 10.96 2245 254321 287478 42077291
Hypotension 64.10 10.96 2016 254550 255615 42109154
Blood pressure systolic abnormal 63.40 10.96 117 256449 5411 42359358
Infusion site extravasation 62.85 10.96 116 256450 5365 42359404
Depressed level of consciousness 62.26 10.96 498 256068 47472 42317297
Malignant neoplasm progression 60.39 10.96 393 256173 108007 42256762
Inappropriate schedule of product administration 60.23 10.96 860 255706 95042 42269727
Generalised bullous fixed drug eruption 60.07 10.96 36 256530 411 42364358
Renal impairment 59.71 10.96 403 256163 109825 42254944
Wrong technique in product usage process 59.66 10.96 103 256463 42532 42322237
Sleep disorder due to a general medical condition 58.97 10.96 16 256550 17437 42347332
Appendicolith 58.22 10.96 196 256370 13260 42351509
Dizziness 57.10 10.96 1107 255459 248147 42116622
Disease progression 56.93 10.96 571 255995 143085 42221684
Dyspnoea 55.70 10.96 2141 254425 440480 41924289
Asthenia 55.57 10.96 1277 255289 279516 42085253
Nightmare 54.69 10.96 296 256270 24716 42340053
Abdominal pain 54.26 10.96 1516 255050 188955 42175814
Blood pressure diastolic decreased 53.94 10.96 161 256405 10214 42354555
Somnolence 53.63 10.96 1168 255398 139937 42224832
Prothrombin time ratio decreased 53.32 10.96 37 256529 552 42364217
Alanine aminotransferase increased 53.22 10.96 787 255779 87619 42277150
Lymphocyte count abnormal 51.96 10.96 65 256501 2122 42362647
Vanishing bile duct syndrome 51.64 10.96 60 256506 1811 42362958
Asthma 51.30 10.96 197 256369 62117 42302652
Pharyngeal paraesthesia 51.12 10.96 43 256523 866 42363903
Body temperature increased 50.82 10.96 250 256316 20108 42344661
Heart rate irregular 50.46 10.96 211 256355 15839 42348930
Mixed liver injury 50.44 10.96 94 256472 4380 42360389
Therapeutic response decreased 50.35 10.96 91 256475 36921 42327848
Hepatic necrosis 50.24 10.96 87 256479 3826 42360943
Cholestatic liver injury 49.64 10.96 84 256482 3625 42361144
Stevens-Johnson syndrome 49.54 10.96 264 256302 21914 42342855
Hospitalisation 49.13 10.96 255 256311 74075 42290694
Fatigue 49.07 10.96 2134 254432 433507 41931262
Dry skin 48.60 10.96 140 256426 48198 42316571
Decreased appetite 48.18 10.96 845 255721 192292 42172477
Poor venous access 48.08 10.96 123 256443 7129 42357640
Hepatic failure 48.06 10.96 393 256173 37707 42327062
Substance abuse 48.02 10.96 140 256426 8765 42356004
Clostridium test positive 46.95 10.96 103 256463 5402 42359367
Depression 46.92 10.96 436 256130 110927 42253842
Prostate cancer 46.58 10.96 127 256439 44516 42320253
Throat irritation 46.28 10.96 178 256388 12858 42351911
Infusion site pain 46.08 10.96 101 256465 5294 42359475
Obstructive airways disorder 45.55 10.96 49 256517 24710 42340059
Renal cortical necrosis 45.52 10.96 23 256543 182 42364587
Delusion of grandeur 45.33 10.96 58 256508 1938 42362831
Coronary artery disease 43.47 10.96 171 256395 53549 42311220
Respiratory arrest 43.02 10.96 306 256260 28118 42336651
Aspartate aminotransferase increased 43.00 10.96 678 255888 76485 42288284
Feeling abnormal 42.51 10.96 246 256320 69540 42295229
Drug-induced liver injury 41.59 10.96 382 256184 37891 42326878
Appendicitis 41.12 10.96 238 256328 20375 42344394
Full blood count abnormal 40.15 10.96 74 256492 29802 42334967
Memory impairment 39.92 10.96 161 256405 50061 42314708
Therapeutic product effect decreased 39.64 10.96 113 256453 39037 42325732
Sedation 38.78 10.96 315 256251 30160 42334609
Head discomfort 38.76 10.96 92 256474 5085 42359684
Neuropathy peripheral 38.62 10.96 409 256157 101444 42263325
Immune effector cell-associated neurotoxicity syndrome 38.48 10.96 135 256431 9326 42355443
Ductus arteriosus premature closure 38.44 10.96 22 256544 229 42364540
Rhinalgia 37.87 10.96 51 256515 1793 42362976
Product prescribing error 37.53 10.96 62 256504 26050 42338719
Blood phosphorus increased 37.32 10.96 162 256404 12363 42352406
Osteonecrosis of jaw 36.97 10.96 36 256530 19013 42345756
Dyspnoea exertional 36.64 10.96 166 256400 49982 42314787
Hyperaesthesia 36.45 10.96 98 256468 5854 42358915
Asphyxia 35.78 10.96 121 256445 8205 42356564
Dermatitis atopic 35.60 10.96 15 256551 12389 42352380
Hyperphosphataemia 35.59 10.96 164 256402 12840 42351929
Acute myocardial infarction 35.44 10.96 205 256361 57960 42306809
Heart rate increased 35.20 10.96 482 256084 52773 42311996
Cerebral haemorrhage 34.84 10.96 119 256447 38847 42325922
Pyrexia 34.53 10.96 2786 253780 391256 41973513
Cerebral artery thrombosis 34.38 10.96 40 256526 1209 42363560
Sinusitis 34.16 10.96 435 256131 46857 42317912
Exposure via ingestion 33.78 10.96 52 256514 2070 42362699
Acidosis 33.71 10.96 155 256411 12124 42352645
Graft versus host disease 33.46 10.96 18 256548 12907 42351862
Glycosylated haemoglobin increased 33.46 10.96 18 256548 12906 42351863
Anaphylactic reaction 33.39 10.96 399 256167 42344 42322425
Interstitial lung disease 33.11 10.96 307 256259 78155 42286614
Injection site swelling 33.03 10.96 32 256534 16941 42347828
Prostatic specific antigen increased 32.83 10.96 32 256534 16893 42347876
Syncope 32.69 10.96 412 256154 98994 42265775
Cerebral infarction 32.27 10.96 89 256477 31080 42333689
Cholestasis 32.18 10.96 321 256245 32558 42332211
Forced expiratory volume decreased 32.17 10.96 4 256562 7626 42357143
Cardiac failure chronic 32.06 10.96 9 256557 9592 42355177
Dehydration 31.98 10.96 631 255935 141136 42223633
Post transplant lymphoproliferative disorder 31.50 10.96 8 256558 9112 42355657
Respiratory rate increased 31.38 10.96 141 256425 10921 42353848
Injection site reaction 31.34 10.96 29 256537 15692 42349077
Drug reaction with eosinophilia and systemic symptoms 31.23 10.96 389 256177 41686 42323083
Adulterated product 30.80 10.96 30 256536 736 42364033
Myasthenia gravis 30.69 10.96 184 256382 15953 42348816
Aplastic anaemia 30.14 10.96 151 256415 12233 42352536
Progressive multifocal leukoencephalopathy 29.96 10.96 16 256550 11520 42353249
Therapy non-responder 29.92 10.96 193 256373 53166 42311603
Erectile dysfunction 29.81 10.96 66 256500 24847 42339922
Infusion site swelling 29.69 10.96 63 256503 3229 42361540
Bone marrow failure 29.63 10.96 101 256465 32992 42331777
Therapy interrupted 29.12 10.96 56 256510 22194 42342575
Accidental death 28.97 10.96 60 256506 3023 42361746
Cerebrovascular accident 28.93 10.96 411 256155 96749 42268020
Bladder cancer 28.92 10.96 36 256530 17011 42347758
Infusion site erythema 28.91 10.96 66 256500 3556 42361213
Haematotoxicity 28.88 10.96 15 256551 10970 42353799
Atrial fibrillation 28.63 10.96 631 255935 138962 42225807
No adverse event 28.60 10.96 129 256437 38892 42325877
Body temperature fluctuation 28.55 10.96 42 256524 1605 42363164
Neuroblastoma recurrent 28.50 10.96 22 256544 390 42364379
Cardiac disorder 28.46 10.96 175 256391 48757 42316012
Monocyte chemotactic protein-1 increased 28.45 10.96 21 256545 347 42364422
Alpha tumour necrosis factor increased 28.20 10.96 21 256545 352 42364417
Infusion site pruritus 28.09 10.96 35 256531 1138 42363631
Product quality issue 28.06 10.96 40 256526 17842 42346927
Ear pruritus 28.02 10.96 28 256538 709 42364060
BK virus infection 27.94 10.96 9 256557 8775 42355994
Transaminases increased 27.93 10.96 312 256254 32573 42332196
Oedema peripheral 27.65 10.96 616 255950 135460 42229309
Pulmonary alveolar haemorrhage 27.62 10.96 29 256537 14787 42349982
Injection site pruritus 27.60 10.96 11 256555 9394 42355375
Labelled drug-drug interaction medication error 27.39 10.96 32 256534 15550 42349219
Oesophageal carcinoma 27.39 10.96 12 256554 9684 42355085
Myocardial fibrosis 27.32 10.96 36 256530 1239 42363530
Hyperlactacidaemia 27.29 10.96 74 256492 4442 42360327
Injection site erythema 27.16 10.96 50 256516 20145 42344624
Pulmonary vasculitis 27.13 10.96 3 256563 6263 42358506
Visual acuity reduced 26.81 10.96 40 256526 17510 42347259
Pathogen resistance 26.76 10.96 18 256548 11432 42353337
Blood glucose increased 26.71 10.96 299 256267 73400 42291369
Skin exfoliation 26.64 10.96 144 256422 41409 42323360
Physical deconditioning 26.45 10.96 50 256516 2355 42362414
Anxiety 26.34 10.96 529 256037 118031 42246738
Therapy cessation 26.30 10.96 52 256514 20398 42344371
Pemphigus 26.28 10.96 45 256521 1961 42362808
Lung neoplasm malignant 26.11 10.96 47 256519 19100 42345669
Hypoxia 25.95 10.96 576 255990 69210 42295559
Device leakage 25.65 10.96 15 256551 10270 42354499
Anaemia 25.56 10.96 1403 255163 278875 42085894
Drug ineffective for unapproved indication 25.36 10.96 168 256398 45995 42318774
Blood immunoglobulin G decreased 25.32 10.96 48 256518 2266 42362503
Parvimonas micra infection 25.31 10.96 11 256555 59 42364710
Drug use disorder 25.15 10.96 126 256440 10207 42354562
Syringe issue 25.12 10.96 10 256556 8546 42356223
Peripheral swelling 25.09 10.96 387 256179 89883 42274886
Postoperative delirium 25.07 10.96 24 256542 576 42364193
Brain scan abnormal 25.04 10.96 34 256532 1205 42363564
Mydriasis 25.04 10.96 112 256454 8658 42356111
Drug dose omission by device 25.03 10.96 3 256563 5883 42358886
Akathisia 25.01 10.96 16 256550 10435 42354334
Immune reconstitution inflammatory syndrome 25.01 10.96 15 256551 10128 42354641
Product substitution issue 24.75 10.96 19 256547 11271 42353498
Acute generalised exanthematous pustulosis 24.72 10.96 110 256456 8485 42356284
Psoriatic arthropathy 24.59 10.96 73 256493 24894 42339875
Injection site bruising 24.51 10.96 20 256546 11505 42353264
Myopathy 24.47 10.96 28 256538 13733 42351036
Vision blurred 24.46 10.96 206 256360 53493 42311276
Rhinitis 24.35 10.96 139 256427 11838 42352931
Fall 24.23 10.96 1159 255407 233361 42131408
Cytomegalovirus infection 24.16 10.96 106 256460 32200 42332569
Inadequate analgesia 24.14 10.96 57 256509 3140 42361629
Urine sodium decreased 23.88 10.96 14 256552 153 42364616
Gastrointestinal haemorrhage 23.87 10.96 429 256137 97297 42267472
Gait inability 23.78 10.96 65 256501 22768 42342001
Sleep disorder therapy 23.55 10.96 93 256473 6801 42357968
Osteonecrosis 23.42 10.96 37 256529 15828 42348941
Full blood count decreased 23.36 10.96 56 256510 20504 42344265
Neutrophil percentage increased 23.05 10.96 42 256524 1923 42362846
Unevaluable event 23.00 10.96 117 256449 34171 42330598
Injection site haemorrhage 22.99 10.96 22 256544 11714 42353055
Muscle spasms 22.87 10.96 372 256194 85672 42279097
Chest pain 22.86 10.96 652 255914 138878 42225891
Pulmonary fibrosis 22.83 10.96 83 256483 26598 42338171
Enterocolitis infectious 22.78 10.96 42 256524 1941 42362828
Hypopnoea 22.76 10.96 101 256465 7781 42356988
Alcohol poisoning 22.59 10.96 98 256468 7476 42357293
Reversible cerebral vasoconstriction syndrome 22.58 10.96 25 256541 715 42364054
Pancytopenia 22.52 10.96 538 256028 117205 42247564
Iron deficiency 22.25 10.96 128 256438 10933 42353836
Neuralgia 22.08 10.96 244 256322 25403 42339366
Cytopenia 22.07 10.96 45 256521 17452 42347317
Sudden infant death syndrome 21.95 10.96 17 256549 303 42364466
Blood pH decreased 21.92 10.96 45 256521 2253 42362516
Tooth injury 21.83 10.96 32 256534 1219 42363550
Insomnia 21.61 10.96 544 256022 117709 42247060
Intraocular pressure increased 21.54 10.96 6 256560 6427 42358342
Renal papillary necrosis 21.35 10.96 13 256553 153 42364616
Leukocytosis 21.34 10.96 273 256293 29435 42335334
Nocardiosis 21.21 10.96 3 256563 5187 42359582
Erythema multiforme 21.09 10.96 117 256449 9860 42354909
Hepatitis C 21.03 10.96 18 256548 10115 42354654
Myalgia 20.95 10.96 430 256136 95650 42269119
Therapy partial responder 20.85 10.96 57 256509 19964 42344805
Conjunctivitis allergic 20.77 10.96 5 256561 5906 42358863
Pruritus 20.68 10.96 927 255639 187844 42176925
Slow speech 20.67 10.96 38 256528 1752 42363017
Infusion site bruising 20.58 10.96 27 256539 925 42363844
Venoocclusive liver disease 20.54 10.96 19 256547 10283 42354486
Hepatitis 20.51 10.96 253 256313 27047 42337722
SARS-CoV-2 test positive 20.30 10.96 101 256465 8159 42356610
Incorrect drug administration rate 20.25 10.96 42 256524 2118 42362651
Sopor 20.25 10.96 30 256536 13172 42351597
Prostatic pain 20.23 10.96 17 256549 342 42364427
Psoriasis 20.15 10.96 191 256375 48413 42316356
Hypothyroidism 20.12 10.96 112 256454 31972 42332797
Off label use 20.09 10.96 4239 252327 634096 41730673
Gait disturbance 20.08 10.96 443 256123 97557 42267212
Interleukin level increased 19.97 10.96 26 256540 884 42363885
Cardiogenic shock 19.78 10.96 313 256253 35327 42329442
C-reactive protein abnormal 19.78 10.96 16 256550 9245 42355524
Sexual dysfunction 19.76 10.96 8 256558 6767 42358002
Injection site rash 19.75 10.96 5 256561 5707 42359062
Aspergillus infection 19.74 10.96 41 256525 15796 42348973
Chronic graft versus host disease 19.48 10.96 6 256560 6019 42358750
Ear infection 19.46 10.96 138 256428 12666 42352103
Contraindicated product administered 19.46 10.96 82 256484 25190 42339579
Balance disorder 19.42 10.96 188 256378 47457 42317312
Mononeuropathy 19.33 10.96 15 256551 268 42364501
Fibrin D dimer increased 19.30 10.96 70 256496 4915 42359854
Migraine 19.30 10.96 236 256330 25178 42339591
Anion gap abnormal 19.25 10.96 18 256548 419 42364350
Skin fissures 19.11 10.96 18 256548 9658 42355111
Ventricular tachycardia 19.07 10.96 105 256461 30055 42334714
Acute phase reaction 19.03 10.96 12 256554 151 42364618
Chronic gastrointestinal bleeding 18.99 10.96 16 256550 323 42364446
Lymphocyte percentage decreased 18.96 10.96 42 256524 2217 42362552
Systemic lupus erythematosus 18.82 10.96 108 256458 9216 42355553
Electrocardiogram QT prolonged 18.78 10.96 191 256375 47754 42317015
Graft versus host disease in gastrointestinal tract 18.78 10.96 4 256562 5139 42359630
Miosis 18.77 10.96 142 256424 13304 42351465
Stress 18.73 10.96 372 256194 43840 42320929
Nasal septum perforation 18.73 10.96 14 256552 236 42364533
Second primary malignancy 18.69 10.96 18 256548 9557 42355212
International normalised ratio increased 18.67 10.96 400 256166 47768 42317001
Drug therapy 18.61 10.96 82 256484 6298 42358471
Acute myeloid leukaemia 18.54 10.96 70 256496 22186 42342583
Transfusion-related circulatory overload 18.50 10.96 23 256543 746 42364023
Mechanical ventilation complication 18.47 10.96 22 256544 682 42364087
Rash 18.47 10.96 1426 255140 275528 42089241
Stomatitis 18.30 10.96 204 256362 50125 42314644
Acute graft versus host disease in skin 18.27 10.96 11 256555 7413 42357356
Diabetic ketoacidosis 18.21 10.96 71 256495 22296 42342473
Injection site mass 18.08 10.96 15 256551 8560 42356209
Aminoaciduria 18.05 10.96 14 256552 250 42364519
Transplant rejection 17.95 10.96 34 256532 13554 42351215
Bilirubin urine present 17.94 10.96 12 256554 168 42364601
Hypothermia 17.94 10.96 133 256433 12382 42352387
Pyroglutamate increased 17.92 10.96 15 256551 300 42364469
Flushing 17.91 10.96 318 256248 36710 42328059
Cystitis haemorrhagic 17.84 10.96 11 256555 7318 42357451
Symmetrical drug-related intertriginous and flexural exanthema 17.82 10.96 24 256542 844 42363925
Neglect of personal appearance 17.78 10.96 16 256550 354 42364415
Brain injury 17.69 10.96 92 256474 7563 42357206
Hypoaesthesia 17.67 10.96 313 256253 71150 42293619
Patient uncooperative 17.66 10.96 21 256545 650 42364119
Granulomatosis with polyangiitis 17.64 10.96 32 256534 1460 42363309
Pneumonia 17.53 10.96 2250 254316 419899 41944870
Areflexia 17.52 10.96 56 256510 3687 42361082
Burns second degree 17.52 10.96 78 256488 6018 42358751
Cytomegalovirus viraemia 17.51 10.96 22 256544 10355 42354414
Catarrh 17.51 10.96 77 256489 5909 42358860
Prothrombin time abnormal 17.50 10.96 24 256542 859 42363910
Urticaria 17.46 10.96 576 255990 73460 42291309
Acute lung injury 17.43 10.96 33 256533 1556 42363213
Renal disorder 17.19 10.96 103 256463 28877 42335892
Ductus arteriosus stenosis foetal 17.18 10.96 12 256554 181 42364588
Oedematous pancreatitis 17.10 10.96 22 256544 739 42364030
Hypophosphataemia 17.01 10.96 197 256369 20748 42344021
Vital functions abnormal 16.95 10.96 16 256550 377 42364392
Infusion site discomfort 16.64 10.96 16 256550 386 42364383
Consciousness fluctuating 16.57 10.96 29 256537 1286 42363483
Confusion postoperative 16.51 10.96 11 256555 153 42364616
Sulphaemoglobinaemia 16.50 10.96 7 256559 35 42364734
Lymphocyte count decreased 16.50 10.96 247 256319 27562 42337207
Rash maculo-papular 16.38 10.96 317 256249 37186 42327583
Skin haemorrhage 16.37 10.96 14 256552 7871 42356898
Surgery 16.29 10.96 53 256513 17563 42347206
Coagulation factor V level decreased 16.26 10.96 13 256553 243 42364526
Laboratory test abnormal 16.22 10.96 77 256489 22901 42341868
Underdose 16.22 10.96 49 256517 16617 42348152
Myelodysplastic syndrome 16.19 10.96 76 256490 22669 42342100
Infusion site rash 16.15 10.96 20 256546 646 42364123
Type 2 diabetes mellitus 16.11 10.96 57 256509 18414 42346355
Epilepsy 16.06 10.96 92 256474 26079 42338690
Cytomegalovirus chorioretinitis 16.01 10.96 4 256562 4607 42360162
Psychiatric decompensation 16.01 10.96 3 256563 4219 42360550
Visual impairment 15.98 10.96 174 256392 42939 42321830
Product complaint 15.95 10.96 8 256558 5969 42358800
Activated partial thromboplastin time prolonged 15.92 10.96 156 256410 15747 42349022
Immunoglobulin G4 related disease 15.91 10.96 13 256553 251 42364518
Anti factor V antibody 15.89 10.96 14 256552 301 42364468
Abdominal discomfort 15.75 10.96 339 256227 74916 42289853
Hyper IgE syndrome 15.69 10.96 11 256555 167 42364602
Accident 15.62 10.96 79 256487 6424 42358345
Gingival pain 15.61 10.96 96 256470 8398 42356371
Product storage error 15.50 10.96 27 256539 11113 42353656
Tuberculosis 15.44 10.96 23 256543 10076 42354693
Acute graft versus host disease 15.40 10.96 16 256550 8199 42356570
Hepatic encephalopathy 15.35 10.96 159 256407 16283 42348486
Anti-erythrocyte antibody positive 15.33 10.96 7 256559 43 42364726
Analgesic drug level above therapeutic 15.29 10.96 14 256552 317 42364452
Blood triglycerides increased 15.28 10.96 47 256519 15849 42348920
Trichoglossia 15.27 10.96 15 256551 372 42364397
Emotional distress 15.17 10.96 48 256518 16045 42348724
Dependent personality disorder 15.15 10.96 8 256558 70 42364699
Angina pectoris 15.07 10.96 126 256440 32770 42331999
Myoclonic epilepsy 15.05 10.96 32 256534 1642 42363127
Neurological symptom 15.04 10.96 23 256543 9968 42354801
Retinal haemorrhage 14.99 10.96 8 256558 5762 42359007
Alcohol interaction 14.98 10.96 37 256529 2098 42362671
SARS-CoV-2 test negative 14.90 10.96 33 256533 1742 42363027
Cerebral palsy 14.88 10.96 15 256551 384 42364385
Agitation 14.82 10.96 499 256067 63815 42300954
Failure to suspend medication 14.79 10.96 15 256551 387 42364382
Brain death 14.76 10.96 46 256520 2988 42361781
Right ventricle outflow tract obstruction 14.69 10.96 7 256559 48 42364721
Hypotensive crisis 14.69 10.96 8 256558 75 42364694
Bezoar 14.62 10.96 27 256539 1249 42363520
Unresponsive to stimuli 14.59 10.96 268 256298 31135 42333634
Salmonella bacteraemia 14.52 10.96 16 256550 455 42364314
Alcoholic coma 14.51 10.96 8 256558 77 42364692
Encephalopathy 14.37 10.96 338 256228 40995 42323774
Normochromic normocytic anaemia 14.37 10.96 20 256546 9011 42355758
Throat tightness 14.33 10.96 103 256463 9496 42355273
Rebound effect 14.26 10.96 14 256552 7365 42357404
Intervertebral discitis 14.25 10.96 46 256520 3044 42361725
Hepatocellular carcinoma 14.22 10.96 17 256549 8177 42356592
Drug interaction 14.06 10.96 1400 255166 265599 42099170
Glucose-6-phosphate dehydrogenase deficiency 14.05 10.96 12 256554 247 42364522
Antacid therapy 14.04 10.96 61 256505 4656 42360113
Adenocarcinoma of colon 14.03 10.96 3 256563 3844 42360925
Treatment noncompliance 13.97 10.96 152 256414 37520 42327249
Urethral valves 13.97 10.96 12 256554 249 42364520
Wound infection 13.90 10.96 92 256474 8254 42356515
Carotid artery occlusion 13.88 10.96 4 256562 4190 42360579
Graft versus host disease in skin 13.88 10.96 7 256559 5205 42359564
Hepatitis cholestatic 13.85 10.96 104 256462 9720 42355049
Systemic infection 13.84 10.96 7 256559 5198 42359571
Renal fusion anomaly 13.84 10.96 8 256558 85 42364684
Transient ischaemic attack 13.80 10.96 133 256433 33606 42331163
Foreign body aspiration 13.68 10.96 13 256553 309 42364460
Oxygen saturation abnormal 13.66 10.96 34 256532 1937 42362832
Steroid dependence 13.66 10.96 78 256488 6644 42358125
Neuroblastoma 13.65 10.96 13 256553 310 42364459
Hand deformity 13.61 10.96 3 256563 3765 42361004
Type I hypersensitivity 13.60 10.96 36 256530 2130 42362639
Pallor 13.59 10.96 247 256319 28639 42336130
Parosmia 13.56 10.96 86 256480 7605 42357164
Carotid artery stenosis 13.46 10.96 8 256558 5428 42359341
Erythema annulare 13.45 10.96 8 256558 90 42364679
Red blood cell sedimentation rate decreased 13.43 10.96 12 256554 263 42364506
Disturbance in attention 13.41 10.96 115 256451 29751 42335018
Escherichia bacteraemia 13.40 10.96 64 256502 5085 42359684
Aplasia pure red cell 13.38 10.96 14 256552 7152 42357617
Ejection fraction decreased 13.36 10.96 78 256488 22009 42342760
Thrombotic microangiopathy 13.31 10.96 45 256521 14737 42350032
Renal cancer 13.30 10.96 18 256548 8206 42356563
Deep vein thrombosis 13.26 10.96 357 256209 76600 42288169
Biliary ischaemia 13.22 10.96 8 256558 93 42364676
Bronchopulmonary aspergillosis 13.20 10.96 66 256500 19363 42345406
Angina unstable 13.15 10.96 31 256535 11417 42353352
Transplant failure 13.12 10.96 4 256562 4040 42360729
Multiple organ dysfunction syndrome 13.11 10.96 712 255854 96323 42268446
Low birth weight baby 13.07 10.96 25 256541 9930 42354839
Anticoagulant therapy 13.01 10.96 58 256508 4477 42360292
Serum sickness 12.99 10.96 36 256530 2189 42362580
Nocturia 12.98 10.96 34 256532 12078 42352691
Anal inflammation 12.95 10.96 36 256530 2193 42362576
Obesity 12.92 10.96 53 256513 16406 42348363
Wrong schedule 12.92 10.96 13 256553 332 42364437
Oral pruritus 12.89 10.96 16 256550 518 42364251
Injury 12.88 10.96 80 256486 22236 42342533
Severe invasive streptococcal infection 12.86 10.96 6 256560 39 42364730
Victim of sexual abuse 12.85 10.96 4 256562 6 42364763
Arthropathy 12.83 10.96 115 256451 29482 42335287
Bacteraemia 12.81 10.96 217 256349 24823 42339946
Respiratory syncytial virus bronchitis 12.80 10.96 8 256558 99 42364670
Lymphocyte count 12.78 10.96 11 256555 229 42364540
Self-medication 12.76 10.96 46 256520 3220 42361549
Eye irritation 12.72 10.96 31 256535 11287 42353482
Candida infection 12.71 10.96 77 256489 21533 42343236
Metastatic lymphoma 12.68 10.96 14 256552 399 42364370
Endocardial fibrosis 12.67 10.96 5 256561 20 42364749
White coat hypertension 12.64 10.96 13 256553 341 42364428
Congenital megacolon 12.64 10.96 7 256559 68 42364701
Pain in extremity 12.59 10.96 760 255806 149844 42214925
Major depression 12.56 10.96 65 256501 5333 42359436
Administration site erythema 12.55 10.96 7 256559 69 42364700
Adverse event 12.50 10.96 87 256479 23553 42341216
Starvation ketoacidosis 12.49 10.96 9 256557 143 42364626
Parkinsonism hyperpyrexia syndrome 12.49 10.96 13 256553 346 42364423
Blood testosterone decreased 12.44 10.96 7 256559 4895 42359874
Hyperthermia 12.42 10.96 123 256443 12451 42352318
Blood immunoglobulin A decreased 12.37 10.96 18 256548 681 42364088
Diffuse large B-cell lymphoma recurrent 12.37 10.96 7 256559 4879 42359890
Tearfulness 12.22 10.96 3 256563 3497 42361272
Plasma cell myeloma 12.21 10.96 207 256359 47371 42317398
Hallucination, visual 12.20 10.96 186 256380 20834 42343935
Therapeutic response unexpected 12.15 10.96 32 256534 11349 42353420
Therapeutic response shortened 12.15 10.96 130 256436 13424 42351345
Prothrombin time prolonged 12.11 10.96 98 256468 9371 42355398
Cardiac arrest 12.09 10.96 788 255778 108532 42256237
Granulocytopenia 12.09 10.96 15 256551 7099 42357670
Sinus tachycardia 12.08 10.96 183 256383 20470 42344299
Metastases to lymph nodes 12.03 10.96 11 256555 5987 42358782
Infusion site nodule 12.02 10.96 8 256558 111 42364658
Polyneuropathy in malignant disease 11.99 10.96 13 256553 363 42364406
Lipodystrophy acquired 11.96 10.96 3 256563 3447 42361322
Prescribed overdose 11.88 10.96 39 256527 12888 42351881
Nephrolithiasis 11.85 10.96 298 256268 36532 42328237
Hemiparesis 11.82 10.96 59 256507 17317 42347452
Multiple sclerosis relapse 11.79 10.96 45 256521 14219 42350550
Allergy test negative 11.73 10.96 9 256557 158 42364611
Acid-base balance disorder mixed 11.71 10.96 6 256560 49 42364720
Environmental exposure 11.69 10.96 11 256555 258 42364511
Loss of consciousness 11.69 10.96 446 256120 91908 42272861
Pharyngeal swelling 11.67 10.96 46 256520 3361 42361408
Exposure via skin contact 11.67 10.96 8 256558 5030 42359739
Urine bilirubin increased 11.60 10.96 7 256559 81 42364688
Bone erosion 11.59 10.96 6 256560 4397 42360372
Congenital multiplex arthrogryposis 11.56 10.96 11 256555 262 42364507
Tumour flare 11.50 10.96 23 256543 1130 42363639
Porcelain gallbladder 11.48 10.96 5 256561 27 42364742
Crystal urine present 11.46 10.96 14 256552 446 42364323
PCO2 decreased 11.45 10.96 30 256536 1764 42363005
Hyperhidrosis 11.42 10.96 660 255906 89852 42274917
Nodule 11.39 10.96 38 256528 12496 42352273
Medication overuse headache 11.39 10.96 10 256556 214 42364555
Teething 11.38 10.96 7 256559 84 42364685
Anion gap increased 11.37 10.96 33 256533 2061 42362708
Metastases to liver 11.36 10.96 55 256511 16271 42348498
Insurance issue 11.33 10.96 52 256514 4064 42360705
Congenital eye disorder 11.31 10.96 10 256556 216 42364553
Vein disorder 11.29 10.96 33 256533 2069 42362700
Gastric cancer 11.27 10.96 15 256551 6888 42357881
Incorrect dosage administered 11.24 10.96 29 256537 1689 42363080
Blood ethanol increased 11.22 10.96 14 256552 456 42364313
SJS-TEN overlap 11.21 10.96 17 256549 668 42364101
Haemoptysis 11.16 10.96 203 256363 45964 42318805
Increased appetite 11.15 10.96 23 256543 8883 42355886
Cytomegalovirus colitis 11.13 10.96 5 256561 3976 42360793
Leukaemia 11.10 10.96 11 256555 5761 42359008
Discoloured vomit 11.02 10.96 18 256548 754 42364015
Infusion site haemorrhage 11.01 10.96 24 256542 1253 42363516
Acute graft versus host disease in intestine 10.99 10.96 5 256561 3946 42360823
Actinic keratosis 10.98 10.96 9 256557 5167 42359602

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 5072.10 10.07 11694 886853 468861 109221891
Completed suicide 4771.68 10.07 7689 890858 234692 109456060
Exposure to toxic agent 3153.56 10.07 1702 896845 11156 109679596
Intentional overdose 2302.48 10.07 3978 894569 128523 109562229
Acute hepatic failure 1489.21 10.07 1655 896892 34813 109655939
Hepatic cytolysis 1059.62 10.07 1731 896816 53322 109637430
Infusion related reaction 1046.53 10.07 5965 892582 375197 109315555
Overdose 1008.87 10.07 4167 894380 229627 109461125
Intentional product misuse 961.76 10.07 2813 895734 130091 109560661
Suicide attempt 938.78 10.07 2379 896168 101015 109589737
Blood pressure fluctuation 833.23 10.07 1864 896683 72960 109617792
Poisoning deliberate 696.94 10.07 961 897586 25370 109665382
Metabolic acidosis 628.79 10.07 2012 896535 97732 109593020
Injection site pain 605.57 10.07 346 898201 177576 109513176
Analgesic drug level increased 569.54 10.07 371 898176 3575 109687177
Product dose omission issue 487.39 10.07 1192 897355 320590 109370162
Suspected suicide 459.47 10.07 592 897955 14607 109676145
Drug ineffective 400.89 10.07 9362 889185 1511178 108179574
Medication error 398.00 10.07 1805 896742 103561 109587191
Pyroglutamic acidosis 396.50 10.07 233 898314 1835 109688917
Rheumatoid arthritis 396.10 10.07 3947 894600 295666 109395086
Myelosuppression 378.63 10.07 146 898401 94194 109596558
Duodenal ulcer perforation 360.47 10.07 2577 895970 175123 109515629
Throat irritation 338.09 10.07 1081 897466 52471 109638281
Injection site erythema 333.68 10.07 174 898373 94002 109596750
Myocardial infarction 332.26 10.07 661 897886 191422 109499330
Folliculitis 330.65 10.07 2415 896132 165238 109525514
Cardiac failure congestive 328.90 10.07 447 898100 150553 109540199
Helicobacter infection 326.18 10.07 2562 895985 179315 109511437
Diarrhoea 324.94 10.07 6927 891620 1132578 108558174
Cytokine release syndrome 310.61 10.07 1263 897284 69043 109621709
Anion gap 307.17 10.07 195 898352 1790 109688962
Heart rate decreased 306.80 10.07 1410 897137 81346 109609406
Muscle injury 295.47 10.07 2059 896488 138748 109552004
Lower respiratory tract infection 292.41 10.07 3142 895405 239964 109450788
Hepatic enzyme increased 287.17 10.07 3921 894626 316971 109373781
Intentional product use issue 286.64 10.07 3179 895368 244727 109446025
Hepatotoxicity 282.51 10.07 1142 897405 62258 109628494
Anti-cyclic citrullinated peptide antibody positive 279.11 10.07 2475 896072 179509 109511243
Irritable bowel syndrome 276.38 10.07 2280 896267 161935 109528817
Depressed level of consciousness 275.16 10.07 1707 896840 110571 109580181
Coagulopathy 274.99 10.07 844 897703 40067 109650685
Anaemia 273.86 10.07 2982 895565 544104 109146648
Hand deformity 270.69 10.07 2841 895706 215665 109475087
Sleep disorder due to general medical condition, insomnia type 268.28 10.07 1621 896926 104022 109586730
Pemphigus 257.92 10.07 2773 895774 211797 109478955
Pericarditis 255.66 10.07 2815 895732 216299 109474453
Disease progression 250.77 10.07 1074 897473 242960 109447792
Wrong technique in product usage process 245.34 10.07 209 898338 87139 109603613
Sinusitis 241.67 10.07 3566 894981 293122 109397630
Malignant neoplasm progression 239.50 10.07 679 897868 173888 109516864
Ill-defined disorder 236.79 10.07 2126 896421 154727 109536025
Blood pressure increased 228.18 10.07 3150 895397 255223 109435529
Glossodynia 227.70 10.07 2782 895765 219222 109471530
Liver injury 227.20 10.07 2039 896508 148374 109542378
Cardiac failure 225.47 10.07 775 897772 186851 109503901
Blood pressure systolic increased 224.61 10.07 1295 897252 81696 109609056
Drug resistance 223.31 10.07 89 898458 56285 109634467
Blister 219.80 10.07 2818 895729 224558 109466194
Wound 219.28 10.07 2888 895659 231549 109459203
Blood pressure diastolic abnormal 216.71 10.07 577 897970 25238 109665514
Blood pressure systolic abnormal 215.29 10.07 562 897985 24288 109666464
Systemic lupus erythematosus 214.61 10.07 3076 895471 251262 109439490
Nasopharyngitis 209.75 10.07 4429 894118 389932 109300820
Poisoning 206.49 10.07 612 897935 28493 109662259
Device expulsion 205.62 10.07 11 898536 30880 109659872
Impaired healing 202.53 10.07 2467 896080 194250 109496502
Renal impairment 201.24 10.07 817 897730 187628 109503124
Ear pruritus 196.67 10.07 268 898279 6992 109683760
Injection site swelling 193.79 10.07 132 898415 61658 109629094
Coma 191.61 10.07 1624 896923 116245 109574507
Accidental overdose 186.09 10.07 875 897672 50959 109639793
Injection site pruritus 185.61 10.07 92 898455 51166 109639586
Synovitis 183.53 10.07 3189 895358 270903 109419849
Drug abuse 175.34 10.07 2208 896339 175203 109515549
Discomfort 174.89 10.07 2581 895966 212126 109478626
Blood pressure diastolic decreased 174.12 10.07 664 897883 35221 109655531
Prothrombin time ratio decreased 162.48 10.07 121 898426 1471 109689281
Rheumatic fever 162.32 10.07 1616 896931 120963 109569789
Injection site bruising 161.45 10.07 109 898438 51154 109639598
Cardio-respiratory arrest 157.23 10.07 1535 897012 114301 109576451
Pancytopenia 155.38 10.07 1030 897517 208583 109482169
Dehydration 154.25 10.07 1488 897059 278023 109412729
Gastrointestinal disorder 150.25 10.07 2782 895765 239170 109451582
Body temperature increased 148.85 10.07 855 897692 53858 109636894
Hepatic necrosis 148.02 10.07 279 898268 9643 109681109
Neutropenia 146.48 10.07 2151 896396 372469 109318283
Dry skin 144.50 10.07 423 898124 107230 109583522
Interstitial lung disease 141.97 10.07 615 897932 138719 109552033
Oxygen saturation decreased 141.40 10.07 1921 896626 155061 109535691
Osteonecrosis of jaw 137.16 10.07 113 898434 47904 109642848
Joint swelling 135.89 10.07 4629 893918 438216 109252536
Hepatic failure 135.32 10.07 990 897557 67749 109623003
Hypersensitivity 134.77 10.07 4265 894282 399733 109291019
Arthropathy 134.11 10.07 3170 895377 284352 109406400
Weight increased 133.46 10.07 4405 894142 415239 109275513
Atrial fibrillation 132.05 10.07 1210 897337 228432 109462320
Therapy interrupted 131.79 10.07 126 898421 49696 109641056
Feeling abnormal 131.42 10.07 893 897654 179818 109510934
Therapy cessation 131.34 10.07 103 898444 44754 109645998
Dyspnoea 130.01 10.07 7515 891032 1099357 108591395
Respiratory depression 129.70 10.07 560 897987 31441 109659311
Drug interaction 129.27 10.07 3085 895462 497098 109193654
White blood cell count decreased 127.89 10.07 1218 897329 228172 109462580
Sedation complication 123.67 10.07 399 898148 19456 109671296
Neuropathy peripheral 121.55 10.07 904 897643 178373 109512379
Hepatitis fulminant 119.47 10.07 234 898313 8326 109682426
Coronary artery disease 119.40 10.07 252 898295 71438 109619314
Swelling 118.11 10.07 3710 894837 347331 109343421
Hepatitis acute 116.78 10.07 377 898170 18389 109672363
Bone marrow failure 116.34 10.07 181 898366 57667 109633085
Gastrointestinal haemorrhage 115.40 10.07 828 897719 164690 109526062
Dyspnoea exertional 114.32 10.07 446 898101 103614 109587138
Full blood count abnormal 113.09 10.07 175 898372 55877 109634875
Neoplasm progression 112.74 10.07 221 898326 64374 109626378
Dermatitis atopic 112.04 10.07 34 898513 25507 109665245
Mobility decreased 111.41 10.07 2620 895927 234802 109455950
Pharyngeal paraesthesia 111.13 10.07 152 898395 3980 109686772
Respiratory arrest 107.05 10.07 826 897721 57473 109633279
Hospitalisation 104.16 10.07 703 897844 141790 109548962
Acute myocardial infarction 102.67 10.07 343 898204 83434 109607318
Creatinine renal clearance decreased 102.03 10.07 399 898148 21416 109669336
Unevaluable event 101.34 10.07 205 898342 59022 109631730
Platelet count decreased 100.84 10.07 1293 897254 229150 109461602
Swollen joint count increased 100.80 10.07 1082 897465 82579 109608173
Cerebrovascular accident 99.16 10.07 967 897580 180317 109510435
Cerebral infarction 97.90 10.07 169 898378 51669 109639083
Syncope 97.14 10.07 1114 897433 201422 109489330
Renal failure 96.67 10.07 1278 897269 225296 109465456
Rheumatoid factor positive 95.86 10.07 1553 896994 130087 109560665
Surgery 95.23 10.07 117 898430 41166 109649586
Heart rate irregular 94.14 10.07 537 898010 33737 109657015
Injection site haemorrhage 92.77 10.07 79 898468 32949 109657803
Drug-induced liver injury 91.77 10.07 1428 897119 118639 109572113
Transient ischaemic attack 90.59 10.07 245 898302 63737 109627015
Injection site warmth 90.56 10.07 16 898531 17389 109673363
Sopor 90.32 10.07 98 898449 36448 109654304
Device difficult to use 90.13 10.07 21 898526 18784 109671968
Confusional state 89.71 10.07 4662 893885 464018 109226734
Blood pressure diastolic increased 89.60 10.07 346 898201 18461 109672291
Product substitution issue 88.76 10.07 38 898509 23023 109667729
Myalgia 88.55 10.07 1272 897275 221109 109469643
Respiratory failure 88.46 10.07 1224 897323 214108 109476644
Facet joint syndrome 88.44 10.07 1188 897359 95640 109595112
Bursitis 88.10 10.07 1515 897032 128403 109562349
Injection site rash 87.91 10.07 40 898507 23379 109667373
Heart rate increased 87.56 10.07 1649 896898 142185 109548567
Prostate cancer 87.54 10.07 106 898441 37535 109653217
Injection site urticaria 87.05 10.07 17 898530 17198 109673554
Visual acuity reduced 86.70 10.07 80 898467 32093 109658659
Contraindicated product administered 86.42 10.07 2635 895912 245632 109445120
Urticaria 85.94 10.07 3285 895262 315572 109375180
Fixed eruption 85.39 10.07 136 898411 4096 109686656
Product prescribing error 85.01 10.07 181 898366 51150 109639602
Post transplant lymphoproliferative disorder 84.25 10.07 13 898534 15600 109675152
Body temperature decreased 83.93 10.07 551 897996 36384 109654368
Forced expiratory volume decreased 83.77 10.07 6 898541 13170 109677582
Cytomegalovirus infection 83.63 10.07 200 898347 54244 109636508
Decreased appetite 83.41 10.07 3093 895454 472753 109217999
Product storage error 83.31 10.07 36 898511 21692 109669060
Drug dose omission by device 83.27 10.07 10 898537 14506 109676246
Cerebral haemorrhage 83.08 10.07 261 898286 64707 109626045
Stomatitis 82.83 10.07 2825 895722 267417 109423335
Device issue 82.73 10.07 95 898452 34440 109656312
Joint range of motion decreased 82.72 10.07 1421 897126 120411 109570341
Myelodysplastic syndrome 82.56 10.07 110 898437 37374 109653378
Septic shock 82.52 10.07 849 897698 156679 109534073
Dizziness 82.50 10.07 4736 893811 693457 108997295
Loss of consciousness 81.66 10.07 1113 897434 195193 109495559
Fibromyalgia 80.76 10.07 1888 896659 169021 109521731
Leukopenia 79.97 10.07 797 897750 147994 109542758
Exposure via ingestion 79.67 10.07 143 898404 4757 109685995
Lip dry 79.43 10.07 1198 897349 98885 109591867
Therapeutic product effect decreased 78.96 10.07 2570 895977 241746 109449006
Pathogen resistance 78.47 10.07 23 898524 17649 109673103
Hypothyroidism 78.44 10.07 315 898232 72584 109618168
Seizure 77.93 10.07 1295 897252 219890 109470862
Deep vein thrombosis 77.83 10.07 743 897804 139144 109551608
Drug use disorder 77.68 10.07 322 898225 17752 109673000
Multiple-drug resistance 76.22 10.07 9 898538 13226 109677526
Acute lung injury 75.97 10.07 110 898437 3041 109687711
Hyperkalaemia 75.67 10.07 721 897826 135075 109555677
Hypocalcaemia 75.14 10.07 275 898272 65091 109625661
Acute myeloid leukaemia 74.03 10.07 122 898425 37988 109652764
Poor venous access 73.90 10.07 394 898153 24128 109666624
Therapeutic product effect incomplete 73.49 10.07 1327 897220 222478 109468274
Thrombotic microangiopathy 73.34 10.07 77 898470 29072 109661680
Vision blurred 73.19 10.07 682 897865 128340 109562412
Blood glucose increased 73.18 10.07 705 897842 131791 109558961
Blood calcium decreased 72.70 10.07 520 898027 35325 109655427
Clostridium test positive 72.52 10.07 224 898323 10669 109680083
Blood cholesterol increased 72.47 10.07 1991 896556 182794 109507958
Muscle spasticity 72.26 10.07 520 898027 35395 109655357
Pyroglutamate increased 72.21 10.07 52 898495 598 109690154
Type 2 diabetes mellitus 72.18 10.07 1919 896628 175313 109515439
Red blood cell sedimentation rate abnormal 72.11 10.07 56 898491 24453 109666299
Palmar-plantar erythrodysaesthesia syndrome 71.90 10.07 140 898407 40885 109649867
Cross sensitivity reaction 71.50 10.07 147 898400 5420 109685332
Injection site mass 71.45 10.07 57 898490 24556 109666196
Epistaxis 71.04 10.07 696 897851 129676 109561076
Immune reconstitution inflammatory syndrome 70.45 10.07 22 898525 16204 109674548
Diabetes mellitus 70.30 10.07 495 898052 98886 109591866
Haematotoxicity 70.26 10.07 42 898505 21040 109669712
Injury 69.81 10.07 1911 896636 175354 109515398
Contusion 69.63 10.07 2432 896115 230929 109459823
Diabetic ketoacidosis 69.07 10.07 149 898398 41909 109648843
Posterior reversible encephalopathy syndrome 69.00 10.07 105 898442 33756 109656996
Infusion site pruritus 68.80 10.07 136 898411 4872 109685880
Aspergillus infection 68.67 10.07 64 898483 25552 109665200
Inspiratory capacity decreased 67.59 10.07 94 898453 2501 109688251
Anion gap abnormal 66.83 10.07 55 898492 781 109689971
Pulmonary hypertension 66.35 10.07 228 898319 54992 109635760
Sedation 66.14 10.07 861 897686 68822 109621930
Device malfunction 66.02 10.07 66 898481 25492 109665260
Oesophageal carcinoma 65.96 10.07 8 898539 11516 109679236
Haemorrhage 65.34 10.07 553 897994 106139 109584613
Prothrombin time shortened 65.25 10.07 111 898436 3535 109687217
Mixed liver injury 64.89 10.07 231 898316 11848 109678904
Osteonecrosis 64.63 10.07 109 898438 33632 109657120
Night sweats 63.88 10.07 1482 897065 132501 109558251
Cytopenia 63.70 10.07 91 898456 30025 109660727
Pneumonia 63.51 10.07 6197 892350 870517 108820235
Fall 62.41 10.07 4144 894403 599338 109091414
Deep vein thrombosis postoperative 62.02 10.07 746 897801 58545 109632207
Transplant rejection 61.69 10.07 65 898482 24502 109666250
Cardiac failure chronic 61.28 10.07 18 898529 13793 109676959
Pulmonary alveolar haemorrhage 60.61 10.07 45 898502 20105 109670647
Exposure via skin contact 60.45 10.07 16 898531 13131 109677621
Second primary malignancy 60.21 10.07 36 898511 18032 109672720
Somnolence 60.18 10.07 2975 895572 294474 109396278
Hypocoagulable state 59.74 10.07 89 898458 2526 109688226
Vomiting 59.37 10.07 8352 890195 902323 108788429
Inappropriate schedule of product administration 59.20 10.07 2116 896431 201521 109489231
Cardiac disorder 58.95 10.07 370 898177 75910 109614842
Bladder cancer 58.90 10.07 47 898500 20245 109670507
Hypotension 58.76 10.07 4981 893566 518868 109171884
Hepatic encephalopathy 58.52 10.07 412 898135 27844 109662908
Generalised bullous fixed drug eruption 58.30 10.07 50 898497 754 109689998
Psoriasis 58.11 10.07 794 897753 139199 109551553
Full blood count decreased 57.60 10.07 108 898439 31991 109658761
Electrocardiogram QT prolonged 57.57 10.07 586 897961 108374 109582378
Infusion site erythema 56.96 10.07 220 898327 11739 109679013
Unintentional medical device removal 56.91 10.07 4 898543 8919 109681833
Wound infection 56.66 10.07 1100 897447 95365 109595387
Disease recurrence 56.15 10.07 278 898269 60506 109630246
Injection site induration 55.99 10.07 12 898535 11371 109679381
Thrombocytopenia 55.79 10.07 2292 896255 346593 109344159
Device use error 55.39 10.07 5 898542 9084 109681668
Graft versus host disease 55.29 10.07 43 898504 18763 109671989
Cytomegalovirus viraemia 54.31 10.07 39 898508 17725 109673027
Hypomania 53.77 10.07 194 898353 10016 109680736
Metastases to liver 53.55 10.07 131 898416 35255 109655497
Respiratory rate increased 53.28 10.07 368 898179 24715 109666037
Ventricular tachycardia 53.23 10.07 217 898330 49792 109640960
Drug ineffective for unapproved indication 52.72 10.07 557 897990 102281 109588471
Sciatica 52.04 10.07 1047 897500 91352 109599400
Infusion site pain 51.90 10.07 279 898268 17140 109673612
Urinary tract infection 51.85 10.07 2145 896402 324137 109366615
Electric shock 51.83 10.07 69 898478 1759 109688993
Sepsis 51.81 10.07 2153 896394 325193 109365559
Pneumocystis jirovecii pneumonia 51.65 10.07 176 898371 42559 109648193
BK virus infection 51.40 10.07 21 898526 13085 109677667
Eosinophilic granulomatosis with polyangiitis 51.08 10.07 12 898535 10674 109680078
Chronic kidney disease 51.06 10.07 386 898161 75905 109614847
Toxic epidermal necrolysis 50.97 10.07 694 897853 56033 109634719
Infusion site swelling 50.61 10.07 186 898361 9691 109681061
Pulmonary arterial hypertension 50.53 10.07 119 898428 32449 109658303
Thrombosis 50.40 10.07 602 897945 108060 109582692
White blood cells urine positive 50.35 10.07 155 898392 7369 109683383
Drug intolerance 50.35 10.07 3895 894652 402617 109288135
Bone pain 50.29 10.07 316 898231 64817 109625935
Inflammation 50.18 10.07 1983 896564 191255 109499497
Schizophrenia 49.83 10.07 326 898221 21500 109669252
Oedema peripheral 49.64 10.07 2173 896374 326487 109364265
Spinal stenosis 49.46 10.07 49 898498 19007 109671745
Ear pain 49.41 10.07 655 897892 52571 109638181
Crystal urine present 49.18 10.07 70 898477 1904 109688848
Hypomagnesaemia 49.18 10.07 288 898259 60082 109630670
Autoimmune disorder 48.96 10.07 776 897771 64707 109626045
Pulmonary embolism 48.84 10.07 1347 897200 213127 109477625
Musculoskeletal stiffness 48.81 10.07 2760 895787 277062 109413690
Chronic graft versus host disease 48.54 10.07 9 898538 9448 109681304
Device leakage 48.06 10.07 36 898511 16012 109674740
Polyneuropathy 48.06 10.07 119 898428 31893 109658859
Therapy partial responder 48.01 10.07 148 898399 36913 109653839
Basal cell carcinoma 47.83 10.07 197 898350 45073 109645679
Neutrophil percentage increased 47.67 10.07 116 898431 4797 109685955
Device dislocation 47.48 10.07 118 898429 31586 109659166
Skin exfoliation 47.30 10.07 469 898078 87182 109603570
Hepatic function abnormal 47.27 10.07 480 898067 88815 109601937
Coeliac disease 47.21 10.07 548 897999 42639 109648113
Gait disturbance 46.99 10.07 1816 896731 276392 109414360
Systemic infection 46.99 10.07 11 898536 9808 109680944
Substance abuse 46.65 10.07 213 898334 12250 109678502
Live birth 46.63 10.07 809 897738 68675 109622077
Therapeutic response unexpected 46.62 10.07 76 898471 23767 109666985
Weight fluctuation 46.51 10.07 324 898223 21821 109668931
Renal disorder 46.45 10.07 225 898322 49254 109641498
Bronchopulmonary aspergillosis 46.42 10.07 109 898438 29754 109660998
Multiple sclerosis relapse 46.27 10.07 230 898317 50010 109640742
Sleep disorder due to a general medical condition 46.06 10.07 242 898305 51870 109638882
No adverse event 45.98 10.07 381 898166 73458 109617294
Infusion site extravasation 45.93 10.07 202 898345 11432 109679320
Product dose omission in error 45.92 10.07 75 898472 23437 109667315
Neurotoxicity 45.65 10.07 182 898365 42025 109648727
Mucosal inflammation 45.60 10.07 530 898017 95611 109595141
Jaundice cholestatic 45.59 10.07 237 898310 14371 109676381
Acute graft versus host disease 45.32 10.07 24 898523 12857 109677895
Angina unstable 45.30 10.07 40 898507 16392 109674360
Acute respiratory failure 45.22 10.07 392 898155 74868 109615884
Alanine aminotransferase increased 45.20 10.07 1875 896672 181898 109508854
Breast cancer 45.06 10.07 161 898386 38381 109652371
Haematuria 44.85 10.07 444 898103 82561 109608191
Urine abnormality 44.69 10.07 169 898378 8927 109681825
Acute kidney injury 44.48 10.07 4502 894045 630928 109059824
Right ventricular failure 44.25 10.07 90 898457 25864 109664888
Acute graft versus host disease in skin 44.13 10.07 16 898531 10724 109680028
Cardiac failure acute 44.11 10.07 80 898467 23998 109666754
Staphylococcal infection 43.97 10.07 360 898187 69584 109621168
Maternal exposure during pregnancy 43.86 10.07 2511 896036 252372 109438380
Obstructive airways disorder 43.82 10.07 209 898338 45940 109644812
Tachycardia 43.80 10.07 2257 896290 224388 109466364
Endophthalmitis 43.76 10.07 7 898540 8180 109682572
Nocardiosis 43.33 10.07 5 898542 7481 109683271
Myopathy 43.03 10.07 86 898461 24874 109665878
Breast cancer female 42.75 10.07 24 898523 12444 109678308
Injection site reaction 42.65 10.07 490 898057 88580 109602172
Blood potassium decreased 42.58 10.07 261 898286 53853 109636899
Dry mouth 42.56 10.07 2010 896537 197938 109492814
Labelled drug-drug interaction medication error 42.39 10.07 111 898436 29191 109661561
Alopecia 42.24 10.07 3477 895070 361276 109329476
Lymphadenopathy 42.24 10.07 324 898223 63511 109627241
Peripheral venous disease 42.13 10.07 937 897610 83180 109607572
Therapeutic response decreased 41.98 10.07 542 898005 95957 109594795
Oral pruritus 41.85 10.07 87 898460 3233 109687519
COVID-19 41.55 10.07 2411 896136 242649 109448103
Treatment noncompliance 41.31 10.07 386 898161 72604 109618148
Cystitis haemorrhagic 41.14 10.07 24 898523 12185 109678567
Renal cortical necrosis 40.90 10.07 34 898513 490 109690262
Body temperature fluctuation 40.87 10.07 93 898454 3680 109687072
Dermatitis 40.61 10.07 105 898442 27732 109663020
Febrile neutropenia 40.51 10.07 3043 895504 313724 109377028
Asthenia 40.29 10.07 4942 893605 684057 109006695
Pleural effusion 40.22 10.07 1117 897430 176592 109514160
Acidosis 40.13 10.07 317 898230 22214 109668538
Abdominal discomfort 40.11 10.07 3719 894828 390139 109300613
Graft versus host disease in skin 39.99 10.07 9 898538 8245 109682507
Hyperlipidaemia 39.78 10.07 153 898394 35695 109655057
Anticipatory anxiety 39.66 10.07 50 898497 1206 109689546
Abortion spontaneous 39.55 10.07 144 898403 34138 109656614
Skin burning sensation 39.55 10.07 73 898474 21752 109669000
Plasma cell myeloma 39.53 10.07 324 898223 62612 109628140
Tremor 39.40 10.07 1297 897250 200935 109489817
Drug withdrawal syndrome 39.34 10.07 167 898380 37887 109652865
Grip strength decreased 39.19 10.07 890 897657 79284 109611468
Methaemoglobinaemia 39.14 10.07 163 898384 9005 109681747
Renal papillary necrosis 38.98 10.07 31 898516 418 109690334
Sudden infant death syndrome 38.95 10.07 28 898519 321 109690431
Product monitoring error 38.95 10.07 12 898535 8915 109681837
Hypothermia 38.89 10.07 355 898192 25947 109664805
Neutrophil count decreased 38.77 10.07 720 897827 120221 109570531
Product preparation error 38.67 10.07 20 898527 10859 109679893
Loss of personal independence in daily activities 38.46 10.07 926 897621 149094 109541658
Mitral valve incompetence 38.45 10.07 140 898407 33189 109657563
Injection site discolouration 38.36 10.07 13 898534 9090 109681662
Epstein-Barr virus infection 38.28 10.07 58 898489 18680 109672072
Pain in jaw 38.13 10.07 251 898296 50926 109639826
Orthostatic hypotension 38.08 10.07 753 897794 65496 109625256
Neuritis 38.07 10.07 7 898540 7392 109683360
Sexual dysfunction 38.06 10.07 11 898536 8519 109682233
Lymphocyte percentage decreased 37.99 10.07 112 898435 5198 109685554
Dyskinesia 37.99 10.07 253 898294 51193 109639559
Neuroblastoma recurrent 37.97 10.07 33 898514 507 109690245
Breast cancer stage III 37.97 10.07 876 897671 78241 109612511
Cardiomyopathy 37.90 10.07 142 898405 33383 109657369
Haemoglobin decreased 37.65 10.07 1644 896903 247083 109443669
Analgesic drug level above therapeutic 37.61 10.07 32 898515 477 109690275
Aggression 37.56 10.07 304 898243 58906 109631846
Mydriasis 37.43 10.07 308 898239 21849 109668903
Accidental exposure to product 37.39 10.07 245 898302 49763 109640989
Urine leukocyte esterase positive 37.38 10.07 90 898457 3696 109687056
Mycotic allergy 37.04 10.07 3 898544 5951 109684801
Pain in extremity 37.04 10.07 3430 895117 483688 109207064
Cholestasis 36.97 10.07 733 897814 63785 109626967
Cognitive disorder 36.90 10.07 952 897595 86559 109604193
Glycosylated haemoglobin increased 36.88 10.07 86 898461 23533 109667219
Gastric cancer 36.59 10.07 22 898525 10986 109679766
Brain death 36.42 10.07 127 898420 6446 109684306
Transaminases increased 36.27 10.07 720 897827 62670 109628082
Finger deformity 36.21 10.07 420 898127 32672 109658080
Incorrect dose administered by device 36.03 10.07 6 898541 6808 109683944
Thinking abnormal 35.88 10.07 42 898505 15098 109675654
Specific gravity urine decreased 35.80 10.07 40 898507 846 109689906
Graft versus host disease in gastrointestinal tract 35.77 10.07 14 898533 8954 109681798
Product label confusion 35.54 10.07 310 898237 22367 109668385
Medication overuse headache 35.42 10.07 53 898494 1510 109689242
Haematochezia 35.42 10.07 693 897854 114831 109575921
Asphyxia 35.35 10.07 217 898330 13998 109676754
Dissociation 35.13 10.07 18 898529 9824 109680928
Complication of device insertion 34.92 10.07 14 898533 8824 109681928
Suicidal ideation 34.72 10.07 545 898002 93392 109597360
Multiple drug therapy 34.62 10.07 143 898404 7871 109682881
Diplopia 34.58 10.07 199 898348 41695 109649057
Erectile dysfunction 34.58 10.07 61 898486 18495 109672257
Renal cancer 34.43 10.07 33 898514 13001 109677751
Metastases to lung 34.41 10.07 86 898461 22977 109667775
Product use issue 34.15 10.07 2959 895588 308736 109382016
Venoocclusive liver disease 34.13 10.07 44 898503 15163 109675589
Squamous cell carcinoma 34.13 10.07 61 898486 18402 109672350
Coronary arterial stent insertion 34.12 10.07 4 898543 5911 109684841
Rebound effect 34.11 10.07 42 898505 14764 109675988
Infective pulmonary exacerbation of cystic fibrosis 33.92 10.07 42 898505 14729 109676023
Blood pH decreased 33.90 10.07 99 898448 4570 109686182
Hypercalcaemia 33.68 10.07 231 898316 46426 109644326
Status epilepticus 33.60 10.07 137 898410 31434 109659318
Osteomyelitis 33.45 10.07 168 898379 36432 109654320
Anion gap increased 33.37 10.07 94 898453 4250 109686502
Depression 33.26 10.07 2176 896371 315159 109375593
Carotid artery stenosis 32.97 10.07 17 898530 9246 109681506
Lymphoproliferative disorder 32.78 10.07 9 898538 7209 109683543
Urinary sediment present 32.76 10.07 67 898480 2461 109688291
Ageusia 32.75 10.07 69 898478 19576 109671176
Cerebral ischaemia 32.73 10.07 30 898517 12074 109678678
Melaena 32.62 10.07 379 898168 68378 109622374
Product use in unapproved indication 32.61 10.07 3160 895387 444217 109246535
Subdural haematoma 32.37 10.07 169 898378 36285 109654467
Hypokalaemia 32.11 10.07 1185 897362 181263 109509489
Breast cancer stage I 32.10 10.07 10 898537 7377 109683375
Brain oedema 31.96 10.07 390 898157 30708 109660044
Intraocular pressure increased 31.81 10.07 25 898522 10851 109679901
Prostatic specific antigen increased 31.53 10.07 33 898514 12478 109678274
Angioedema 31.50 10.07 1035 897512 97465 109593287
Red blood cell sedimentation rate 31.42 10.07 3 898544 5211 109685541
Blood triglycerides increased 31.38 10.07 95 898452 23831 109666921
Hepatocellular carcinoma 31.12 10.07 21 898526 9859 109680893
Hypertensive crisis 31.10 10.07 98 898449 24274 109666478
Left ventricular dysfunction 31.02 10.07 93 898454 23400 109667352
Hepatitis B reactivation 31.00 10.07 11 898536 7473 109683279
Appendicolith 30.79 10.07 210 898337 14045 109676707
Product complaint 30.77 10.07 41 898506 13931 109676821
Paradoxical drug reaction 30.74 10.07 21 898526 9796 109680956
Personality disorder 30.70 10.07 194 898353 12643 109678109
Immunosuppressant drug level increased 30.60 10.07 30 898517 11694 109679058
Adjustment disorder with depressed mood 30.56 10.07 514 898033 43369 109647383
Speech disorder 30.54 10.07 336 898211 61233 109629519
Aplastic anaemia 30.50 10.07 317 898230 23991 109666761
Bezoar 30.44 10.07 87 898460 3967 109686785
Hyponatraemia 30.43 10.07 1451 897096 216202 109474550
Metastases to bone 30.42 10.07 141 898406 31231 109659521
Intervertebral discitis 30.41 10.07 125 898422 6865 109683887
Syringe issue 30.33 10.07 20 898527 9505 109681247
Needle issue 30.30 10.07 62 898485 17778 109672974
Bundle branch block left 30.28 10.07 36 898511 12852 109677900
Enthesopathy 30.24 10.07 34 898513 12444 109678308
Hypertriglyceridaemia 30.19 10.07 53 898494 16101 109674651
Pulmonary vasculitis 30.13 10.07 8 898539 6552 109684200
Abdominal pain 30.02 10.07 4677 893870 508312 109182440
Accidental poisoning 29.99 10.07 64 898483 2423 109688329
Skin toxicity 29.78 10.07 31 898516 11752 109679000
Tardive dyskinesia 29.75 10.07 40 898507 13539 109677213
Skin ulcer 29.74 10.07 352 898195 63293 109627459
Accidental death 29.70 10.07 99 898448 4910 109685842
Onychomadesis 29.69 10.07 529 898018 45134 109645618
JC virus infection 29.49 10.07 4 898543 5286 109685466
Genital haemorrhage 29.46 10.07 11 898536 7241 109683511
Delusion of grandeur 29.41 10.07 60 898487 2200 109688552
Candida infection 29.31 10.07 249 898298 47760 109642992
Incorrect drug administration rate 29.30 10.07 105 898442 5403 109685349
Cytomegalovirus infection reactivation 29.24 10.07 66 898481 18267 109672485
Colorectal cancer 29.21 10.07 19 898528 9095 109681657
Irritability 29.18 10.07 248 898299 47561 109643191
Ductus arteriosus stenosis foetal 29.13 10.07 16 898531 109 109690643
Hypervolaemia 29.10 10.07 259 898288 49201 109641551
Tricuspid valve incompetence 29.07 10.07 98 898449 23775 109666977
Dislocation of vertebra 28.96 10.07 508 898039 43213 109647539
Eczema 28.93 10.07 413 898134 71880 109618872
Arrhythmia 28.72 10.07 395 898152 69180 109621572
Asthma 28.71 10.07 1702 896845 248589 109442163
Disturbance in attention 28.54 10.07 344 898203 61651 109629101
Cellulitis 28.53 10.07 792 897755 125224 109565528
Skin necrosis 28.51 10.07 85 898462 21427 109669325
Tendonitis 28.51 10.07 112 898435 25971 109664781
Neurologic neglect syndrome 28.43 10.07 150 898397 9148 109681604
Sensitivity to weather change 28.15 10.07 24 898523 10004 109680748
Visual impairment 28.14 10.07 854 897693 133574 109557178
C-reactive protein 28.04 10.07 373 898174 29958 109660794
Mucormycosis 27.97 10.07 27 898520 10601 109680151
Chronic obstructive pulmonary disease 27.92 10.07 674 897873 108484 109582268
Actinic keratosis 27.89 10.07 11 898536 7002 109683750
Pericardial effusion 27.69 10.07 314 898233 56903 109633849
Hepatitis C 27.58 10.07 37 898510 12536 109678216
Infusion site mass 27.55 10.07 50 898497 1678 109689074
Torsade de pointes 27.36 10.07 93 898454 22507 109668245
Conjunctivitis allergic 27.35 10.07 11 898536 6920 109683832
Granulocytopenia 27.31 10.07 38 898509 12677 109678075
Transplant dysfunction 27.18 10.07 17 898530 8311 109682441
Circulatory collapse 27.15 10.07 221 898326 42772 109647980
Peripheral swelling 27.13 10.07 3713 894834 400321 109290431
Blood loss anaemia 27.06 10.07 67 898480 17958 109672794
Muscle spasms 27.04 10.07 1920 896627 276237 109414515
Pneumatosis intestinalis 27.04 10.07 18 898529 8511 109682241
Large intestine polyp 27.00 10.07 51 898496 15066 109675686
Mania 26.97 10.07 83 898464 20713 109670039
Complication of device removal 26.96 10.07 3 898544 4617 109686135
Rash pruritic 26.91 10.07 599 897948 97470 109593282
Eye pruritus 26.88 10.07 156 898391 32619 109658133
Concomitant disease aggravated 26.85 10.07 58 898489 16306 109674446
Intestinal haemorrhage 26.84 10.07 13 898534 7328 109683424
Uterine perforation 26.76 10.07 11 898536 6829 109683923
Ankylosing spondylitis 26.74 10.07 54 898493 15558 109675194
Fracture 26.73 10.07 107 898440 24681 109666071
Pancreatic carcinoma 26.72 10.07 50 898497 14822 109675930
Paraesthesia ear 26.66 10.07 27 898520 508 109690244
Alpha tumour necrosis factor increased 26.62 10.07 24 898523 388 109690364
C-reactive protein abnormal 26.58 10.07 1299 897248 128396 109562356
Iron deficiency anaemia 26.54 10.07 149 898398 31410 109659342
Bilirubin urine present 26.52 10.07 22 898525 316 109690436
Eye irritation 26.50 10.07 161 898386 33291 109657461
Osmolar gap 26.43 10.07 17 898530 160 109690592
Spinal compression fracture 26.35 10.07 70 898477 18322 109672430
Retinal haemorrhage 26.35 10.07 23 898524 9478 109681274
Hepatitis 26.21 10.07 936 897611 89118 109601634
Impaired quality of life 26.19 10.07 140 898407 29877 109660875
Carpal tunnel syndrome 26.06 10.07 95 898452 22515 109668237
X-ray abnormal 26.01 10.07 445 898102 37672 109653080
Cardiotoxicity 25.93 10.07 62 898485 16819 109673933
Low density lipoprotein increased 25.92 10.07 29 898518 10637 109680115
Wrong technique in device usage process 25.57 10.07 12 898535 6889 109683863
Kidney transplant rejection 25.57 10.07 36 898511 11951 109678801
Disturbance in social behaviour 25.57 10.07 5 898542 5053 109685699
Cytomegalovirus chorioretinitis 25.49 10.07 13 898534 7115 109683637
Dysstasia 25.48 10.07 160 898387 32826 109657926
Aortic valve incompetence 25.45 10.07 31 898516 10950 109679802
Head injury 25.42 10.07 225 898322 42792 109647960
Electrolyte imbalance 25.42 10.07 186 898361 36842 109653910
Nausea 25.42 10.07 9338 889209 1226352 108464400
Acute coronary syndrome 25.41 10.07 99 898448 23013 109667739
Maternal exposure timing unspecified 25.41 10.07 272 898275 20741 109670011
Blood parathyroid hormone decreased 25.33 10.07 42 898505 13047 109677705
Respiratory symptom 25.33 10.07 52 898495 14893 109675859
Pollakiuria 25.32 10.07 233 898314 43962 109646790
Varicella zoster virus infection 25.31 10.07 10 898537 6358 109684394
Onychomycosis 25.27 10.07 447 898100 38084 109652668
Immune effector cell-associated neurotoxicity syndrome 25.25 10.07 206 898341 14576 109676176
Hypertension 25.23 10.07 4609 893938 505475 109185277
Polyomavirus-associated nephropathy 25.08 10.07 18 898529 8183 109682569
Haemoptysis 25.03 10.07 418 898129 70936 109619816
Blood immunoglobulin E increased 24.80 10.07 15 898532 7467 109683285
Lung neoplasm malignant 24.70 10.07 167 898380 33675 109657077
Infusion site rash 24.55 10.07 57 898490 2286 109688466
Lymphocyte count decreased 24.51 10.07 624 897923 56619 109634133
Intracranial pressure increased 24.45 10.07 158 898389 10377 109680375
Aplasia pure red cell 24.44 10.07 25 898522 9553 109681199
Total lung capacity increased 24.31 10.07 94 898453 5018 109685734
Psoriatic arthropathy 24.28 10.07 1885 896662 194876 109495876
Ventricular extrasystoles 24.25 10.07 98 898449 22543 109668209
SARS-CoV-2 test positive 24.24 10.07 227 898320 16708 109674044
Nocturia 24.09 10.07 65 898482 16925 109673827
Adenocarcinoma of colon 24.00 10.07 10 898537 6158 109684594
Pharyngeal oedema 23.94 10.07 62 898485 16366 109674386
Drug eruption 23.85 10.07 300 898247 53359 109637393
Ataxia 23.80 10.07 145 898402 29963 109660789
Mental disorder 23.77 10.07 201 898346 38590 109652162
Infection 23.76 10.07 3324 895223 358876 109331876
Ascites 23.74 10.07 573 897974 92235 109598517
Gastric disorder 23.66 10.07 166 898381 33191 109657561
Aspartate aminotransferase increased 23.65 10.07 1555 896992 158381 109532371
Leukaemia 23.65 10.07 16 898531 7502 109683250
Glucose tolerance impaired 23.63 10.07 27 898520 9810 109680942
Cytomegalovirus colitis 23.63 10.07 14 898533 7047 109683705
Limb discomfort 23.57 10.07 215 898332 40639 109650113
Vaginal haemorrhage 23.55 10.07 114 898433 24960 109665792
Vascular stent thrombosis 23.54 10.07 3 898544 4158 109686594
Human herpesvirus 6 infection 23.54 10.07 12 898535 6569 109684183
Hepatitis cholestatic 23.44 10.07 232 898315 17334 109673418
Hepatic cancer 23.31 10.07 34 898513 11122 109679630
Diffuse large B-cell lymphoma recurrent 23.27 10.07 11 898536 6288 109684464
Complications of transplanted kidney 23.20 10.07 16 898531 7426 109683326
Cryopyrin associated periodic syndrome 23.19 10.07 27 898520 598 109690154
Sputum culture positive 23.18 10.07 77 898470 3812 109686940
White coat hypertension 23.14 10.07 40 898507 1291 109689461
Mycobacterial infection 23.11 10.07 4 898543 4413 109686339
Brain stem glioma 23.08 10.07 17 898530 203 109690549
Hypercholesterolaemia 23.06 10.07 930 897617 89907 109600845
Oral pain 22.95 10.07 194 898353 37250 109653502
Monocyte chemotactic protein-1 increased 22.92 10.07 21 898526 347 109690405
Application site pain 22.92 10.07 8 898539 5491 109685261
Tachyarrhythmia 22.91 10.07 20 898527 8241 109682511
Congestive cardiomyopathy 22.83 10.07 51 898496 14168 109676584
Skin lesion 22.82 10.07 289 898258 51342 109639410
Infusion site bruising 22.79 10.07 74 898473 3620 109687132
Ischaemic cardiomyopathy 22.70 10.07 19 898528 7992 109682760
Injection site discomfort 22.68 10.07 14 898533 6893 109683859
Carotid artery thrombosis 22.64 10.07 145 898402 9493 109681259
Nail disorder 22.63 10.07 624 897923 57311 109633441
Sleep disorder 22.56 10.07 1891 896656 196753 109493999
Enterococcal infection 22.55 10.07 87 898460 20279 109670473
Proteinuria 22.48 10.07 212 898335 39806 109650946
Arteriosclerosis 22.46 10.07 114 898433 24653 109666099
Akathisia 22.41 10.07 68 898479 17045 109673707
Acute generalised exanthematous pustulosis 22.40 10.07 272 898275 21392 109669360
Spinal operation 22.38 10.07 34 898513 10938 109679814
Toxicologic test abnormal 22.35 10.07 39 898508 1268 109689484
Vital capacity decreased 22.35 10.07 51 898496 2022 109688730
Leukoencephalopathy 22.34 10.07 25 898522 9170 109681582
Withdrawal syndrome 22.33 10.07 156 898391 31224 109659528
Acute graft versus host disease in intestine 22.17 10.07 9 898538 5630 109685122
Embolic stroke 22.10 10.07 23 898524 8720 109682032
Secretion discharge 22.08 10.07 87 898460 20157 109670595
Eyelid ptosis 22.06 10.07 47 898500 13280 109677472
Sleep apnoea syndrome 21.99 10.07 216 898331 40231 109650521
Skin irritation 21.98 10.07 64 898483 16255 109674497
Device deployment issue 21.93 10.07 4 898543 4249 109686503
Total lung capacity decreased 21.91 10.07 115 898432 6999 109683753
Lower limb fracture 21.89 10.07 783 897764 74565 109616187
Hyperglycaemia 21.86 10.07 525 898022 84565 109606187
Metastases to central nervous system 21.86 10.07 103 898444 22714 109668038
Macular oedema 21.68 10.07 15 898532 6951 109683801
Skin cancer 21.66 10.07 73 898474 17711 109673041
Temperature regulation disorder 21.51 10.07 178 898369 12648 109678104
Hypertransaminasaemia 21.49 10.07 296 898251 23959 109666793
Blepharospasm 21.48 10.07 591 897956 54260 109636492
Abdominal pain upper 21.47 10.07 3192 895355 345919 109344833
Mood altered 21.36 10.07 95 898452 21280 109669472
Cystic fibrosis 21.30 10.07 6 898541 4725 109686027
Fluid retention 21.27 10.07 593 897954 93714 109597038
Coagulation factor V level decreased 21.27 10.07 27 898520 656 109690096
Galactorrhoea 21.23 10.07 4 898543 4151 109686601
Abnormal dreams 21.21 10.07 45 898502 12735 109678017
SJS-TEN overlap 21.20 10.07 47 898500 1827 109688925
Klebsiella infection 21.18 10.07 87 898460 19922 109670830
Anger 21.17 10.07 81 898466 18926 109671826
Oropharyngeal discomfort 21.05 10.07 150 898397 10177 109680575
Device defective 21.04 10.07 3 898544 3819 109686933
Bacterial test 21.02 10.07 36 898511 1153 109689599
Pulmonary tuberculosis 20.97 10.07 26 898521 9113 109681639
Metastases to lymph nodes 20.95 10.07 58 898489 14974 109675778
Fear 20.89 10.07 107 898440 23086 109667666
Ketoacidosis 20.82 10.07 31 898516 10056 109680696
Symmetrical drug-related intertriginous and flexural exanthema 20.82 10.07 47 898500 1850 109688902
Injection site irritation 20.81 10.07 7 898540 4917 109685835
Injection site nodule 20.71 10.07 6 898541 4640 109686112
Postoperative delirium 20.70 10.07 31 898516 884 109689868
Aortic valve stenosis 20.68 10.07 13 898534 6337 109684415
Spinal osteoarthritis 20.60 10.07 89 898458 20094 109670658
Acute myeloid leukaemia recurrent 20.54 10.07 8 898539 5131 109685621
Device failure 20.53 10.07 17 898530 7190 109683562
Gingival hypertrophy 20.43 10.07 5 898542 4326 109686426
Blood creatine phosphokinase increased 20.43 10.07 445 898102 72632 109618120
Ovarian hyperstimulation syndrome 20.36 10.07 9 898538 5351 109685401
Embedded device 20.36 10.07 4 898543 4029 109686723
Nasal necrosis 20.23 10.07 15 898532 181 109690571
Mite allergy 20.14 10.07 11 898536 5792 109684960
Glutathione decreased 20.09 10.07 10 898537 54 109690698
Metabolic disorder 20.09 10.07 34 898513 10476 109680276
Epstein-Barr virus associated lymphoproliferative disorder 19.99 10.07 7 898540 4795 109685957
Hypoacusis 19.96 10.07 186 898361 35005 109655747
Muscle disorder 19.94 10.07 15 898532 6657 109684095
Foot operation 19.92 10.07 18 898529 7295 109683457
Ejection fraction decreased 19.92 10.07 224 898323 40656 109650096
Cardiac operation 19.90 10.07 12 898535 5983 109684769
Hypophagia 19.89 10.07 304 898243 52322 109638430
Lipodystrophy acquired 19.88 10.07 6 898541 4518 109686234
Hallucination 19.87 10.07 650 897897 100782 109589970
Coronary artery occlusion 19.72 10.07 64 898483 15708 109675044
Skin discolouration 19.69 10.07 280 898267 48766 109641986
Polydipsia 19.69 10.07 20 898527 7668 109683084
Parvimonas micra infection 19.67 10.07 11 898536 78 109690674
Peripheral arterial occlusive disease 19.67 10.07 28 898519 9252 109681500
Panniculitis 19.64 10.07 63 898484 15519 109675233
Supraventricular tachycardia 19.63 10.07 117 898430 24305 109666447
Hyperthyroidism 19.60 10.07 148 898399 29113 109661639
Anti-cyclic citrullinated peptide antibody 19.50 10.07 248 898299 19716 109671036
Pericardial haemorrhage 19.44 10.07 9 898538 5208 109685544
Stevens-Johnson syndrome 19.42 10.07 509 898038 46392 109644360
Exposure to SARS-CoV-2 19.41 10.07 60 898487 2859 109687893
Myocardial ischaemia 19.31 10.07 132 898415 26552 109664200
Peritonitis bacterial 19.29 10.07 35 898512 10498 109680254
Device breakage 19.28 10.07 53 898494 13716 109677036
Urine bilirubin decreased 19.23 10.07 13 898534 134 109690618
Allergy test negative 19.18 10.07 20 898527 390 109690362
Gestational diabetes 19.18 10.07 19 898528 7370 109683382
Adulterated product 19.15 10.07 34 898513 1121 109689631
Eye haemorrhage 19.09 10.07 42 898505 11732 109679020
Dysgeusia 19.04 10.07 428 898119 69557 109621195
Intentional dose omission 19.03 10.07 91 898456 19989 109670763
Hypersensitivity vasculitis 18.99 10.07 17 898530 6920 109683832
Pyrexia 18.92 10.07 7828 890719 890437 108800315
Personality change 18.89 10.07 38 898509 10964 109679788
Dry eye 18.87 10.07 329 898218 55464 109635288
Cryptococcosis 18.86 10.07 7 898540 4624 109686128
Fear of injection 18.77 10.07 27 898520 8884 109681868
Delirium 18.76 10.07 1306 897241 133719 109557033
Lung infiltration 18.75 10.07 120 898427 24508 109666244
Gastrointestinal toxicity 18.72 10.07 39 898508 11109 109679643
Squamous cell carcinoma of skin 18.72 10.07 74 898473 17129 109673623
Infection reactivation 18.70 10.07 5 898542 4076 109686676
Self-medication 18.69 10.07 100 898447 6132 109684620
Blood glucose abnormal 18.63 10.07 49 898498 12867 109677885
Ischaemic stroke 18.60 10.07 230 898317 41033 109649719
Liver function test increased 18.59 10.07 889 897658 87659 109603093
Unresponsive to stimuli 18.56 10.07 663 897884 63127 109627625
Femur fracture 18.52 10.07 252 898295 44217 109646535
Thirst 18.52 10.07 102 898445 21605 109669147
Prostatic pain 18.50 10.07 17 898530 282 109690470
Coordination abnormal 18.49 10.07 298 898249 24930 109665822
Cyanosis neonatal 18.46 10.07 10 898537 66 109690686
Hepatitis B 18.46 10.07 31 898516 9581 109681171
Lupus vulgaris 18.43 10.07 382 898165 33501 109657251
Foetal heart rate abnormal 18.41 10.07 25 898522 650 109690102
Rheumatoid lung 18.39 10.07 6 898541 4298 109686454
Neurological symptom 18.38 10.07 65 898482 15543 109675209
Cardiovascular disorder 18.31 10.07 109 898438 22651 109668101
Neoplasm malignant 18.30 10.07 203 898344 36940 109653812
Product physical issue 18.29 10.07 9 898538 5027 109685725
Administration site swelling 18.17 10.07 24 898523 607 109690145
Diabetic neuropathy 18.16 10.07 18 898529 6981 109683771
Neoplasm recurrence 18.04 10.07 10 898537 5222 109685530
Product dispensing error 17.98 10.07 70 898477 16275 109674477
Arterial occlusive disease 17.98 10.07 197 898350 15111 109675641
Abnormal loss of weight 17.98 10.07 35 898512 10222 109680530
Prothrombin time prolonged 17.97 10.07 217 898330 17044 109673708
International normalised ratio increased 17.97 10.07 870 897677 85902 109604850
Viral haemorrhagic cystitis 17.96 10.07 3 898544 3396 109687356
Dysuria 17.95 10.07 363 898184 59868 109630884
Viral load increased 17.89 10.07 3 898544 3387 109687365
B-cell lymphoma 17.88 10.07 19 898528 7135 109683617
Dyspnoea at rest 17.87 10.07 25 898522 8321 109682431
Exposure during pregnancy 17.79 10.07 1586 896961 165838 109524914
Condition aggravated 17.72 10.07 5518 893029 729318 108961434
Transplant failure 17.72 10.07 12 898535 5623 109685129
Fungal infection 17.70 10.07 298 898249 50508 109640244
Granuloma skin 17.69 10.07 41 898506 11242 109679510
Generalised tonic-clonic seizure 17.68 10.07 325 898222 54355 109636397
Rhinalgia 17.68 10.07 71 898476 3858 109686894
Tooth injury 17.65 10.07 49 898498 2197 109688555
Liver transplant 17.60 10.07 79 898468 4510 109686242
Ductus arteriosus premature closure 17.60 10.07 11 898536 98 109690654
Secondary immunodeficiency 17.53 10.07 8 898539 4668 109686084
Coronary artery bypass 17.53 10.07 14 898533 6028 109684724
Uterine cancer 17.52 10.07 6 898541 4168 109686584
Burning sensation 17.52 10.07 428 898119 68784 109621968
Amenorrhoea 17.51 10.07 30 898517 9201 109681551
Red blood cells urine positive 17.50 10.07 86 898461 5099 109685653
Underdose 17.49 10.07 388 898159 63166 109627586
Deafness 17.46 10.07 136 898411 26573 109664179
Erysipelas 17.43 10.07 52 898495 13106 109677646
Ventricular hypokinesia 17.38 10.07 41 898506 11173 109679579
Cardiac murmur 17.34 10.07 289 898258 24339 109666413
Dysphoria 17.30 10.07 16 898531 6412 109684340
Dust allergy 17.29 10.07 14 898533 5987 109684765
Injury associated with device 17.26 10.07 7 898540 4382 109686370
Stent placement 17.22 10.07 20 898527 7214 109683538
Oesophageal candidiasis 17.22 10.07 43 898504 11491 109679261
Anaphylactic reaction 17.20 10.07 1113 897434 113187 109577565
Epstein-Barr viraemia 17.15 10.07 4 898543 3575 109687177
Road traffic accident 17.12 10.07 1051 897496 106347 109584405
Hypoglycaemic coma 17.11 10.07 12 898535 5521 109685231
Mononeuropathy 17.10 10.07 18 898529 355 109690397
Paresis 17.08 10.07 9 898538 4835 109685917
Pelvic pain 17.08 10.07 69 898478 15873 109674879
Hypopnoea 17.03 10.07 154 898393 11226 109679526
Emotional distress 16.97 10.07 259 898288 44588 109646164
Gynaecomastia 16.97 10.07 32 898515 9458 109681294
Bronchopulmonary aspergillosis allergic 16.95 10.07 122 898425 8304 109682448
Restrictive pulmonary disease 16.95 10.07 3 898544 3256 109687496
Mood swings 16.93 10.07 112 898435 22700 109668052
Potentiating drug interaction 16.92 10.07 44 898503 11599 109679153
Skin disorder 16.87 10.07 246 898301 42667 109648085
Nephrogenic systemic fibrosis 16.81 10.07 12 898535 5471 109685281
Device related infection 16.80 10.07 223 898324 39296 109651456
Bone disorder 16.78 10.07 102 898445 21090 109669662
Polycystic ovaries 16.78 10.07 9 898538 4787 109685965
Fanconi syndrome 16.73 10.07 4 898543 3515 109687237
Pre-existing condition improved 16.69 10.07 17 898530 6509 109684243
Drug effective for unapproved indication 16.68 10.07 59 898488 14108 109676644
Adjustment disorder 16.62 10.07 147 898400 10648 109680104
Coagulation factor decreased 16.53 10.07 17 898530 326 109690426
Hip arthroplasty 16.46 10.07 581 897966 55232 109635520
Gangrene 16.39 10.07 204 898343 16137 109674615
Alcoholic coma 16.39 10.07 10 898537 85 109690667
Anhedonia 16.38 10.07 67 898480 15361 109675391
Infusion site discomfort 16.38 10.07 42 898505 1795 109688957
Movement disorder 16.38 10.07 203 898344 36201 109654551
Abnormal behaviour 16.34 10.07 221 898326 38818 109651934
Malignant melanoma 16.33 10.07 76 898471 16815 109673937
Normochromic normocytic anaemia 16.31 10.07 53 898494 13004 109677748
Catheter site bruise 16.29 10.07 22 898525 569 109690183
Palpitations 16.28 10.07 1094 897453 158118 109532634
Application site erythema 16.27 10.07 13 898534 5597 109685155
Skin fissures 16.24 10.07 124 898423 24334 109666418
Brain scan abnormal 16.22 10.07 38 898509 1533 109689219
Back injury 16.18 10.07 502 898045 46897 109643855
Hepatitis E 16.15 10.07 8 898539 4451 109686301
Disseminated tuberculosis 16.12 10.07 11 898536 5135 109685617
Fungal rhinitis 16.10 10.07 10 898537 88 109690664
Hiatus hernia 16.05 10.07 145 898402 27461 109663291
Meniscus injury 16.04 10.07 24 898523 7769 109682983
Tuberculosis 16.01 10.07 82 898465 17692 109673060
Harlequin syndrome 15.98 10.07 15 898532 256 109690496
Catheterisation cardiac 15.98 10.07 16 898531 6175 109684577
Blood creatinine decreased 15.97 10.07 128 898419 9009 109681743
Neonatal respiratory acidosis 15.96 10.07 9 898538 65 109690687
Flatulence 15.93 10.07 313 898234 51836 109638916
Colon cancer 15.88 10.07 74 898473 16369 109674383
Akinesia 15.87 10.07 5 898542 3662 109687090
Local anaesthetic systemic toxicity 15.85 10.07 13 898534 5524 109685228
Flushing 15.79 10.07 1020 897527 103716 109587036
Cutaneous T-cell lymphoma 15.79 10.07 4 898543 3380 109687372
Cerebral artery thrombosis 15.78 10.07 39 898508 1629 109689123
Gastroenteritis 15.76 10.07 221 898326 38579 109652173
Diverticulum intestinal 15.75 10.07 46 898501 11673 109679079
High density lipoprotein decreased 15.75 10.07 14 898533 5719 109685033
Administration site bruise 15.75 10.07 14 898533 222 109690530
Coronary artery stenosis 15.73 10.07 58 898489 13700 109677052
Histoplasmosis disseminated 15.70 10.07 6 898541 3893 109686859
Blood immunoglobulin A decreased 15.69 10.07 47 898500 2201 109688551
Nail bed inflammation 15.67 10.07 44 898503 1986 109688766
Nutritional supplementation 15.67 10.07 8 898539 46 109690706
Coagulation factor X level decreased 15.64 10.07 10 898537 93 109690659
Anti-erythrocyte antibody positive 15.62 10.07 9 898538 68 109690684
Heavy menstrual bleeding 15.60 10.07 74 898473 16291 109674461
Glomerular filtration rate decreased 15.59 10.07 155 898392 28801 109661951
Pemphigoid 15.53 10.07 95 898452 19612 109671140
Drug provocation test 15.52 10.07 7 898540 29 109690723
Delusion 15.51 10.07 121 898426 23634 109667118
Loss of employment 15.51 10.07 4 898543 3340 109687412
Intestinal obstruction 15.50 10.07 322 898225 52905 109637847
Cells in urine 15.49 10.07 13 898534 190 109690562
Splenomegaly 15.44 10.07 126 898421 24372 109666380
Anuria 15.43 10.07 125 898422 24216 109666536
Cachexia 15.42 10.07 54 898493 12951 109677801
Consciousness fluctuating 15.41 10.07 46 898501 2150 109688602
Drug screen positive 15.41 10.07 97 898450 6313 109684439
Amniotic cavity disorder 15.39 10.07 8 898539 48 109690704
Focal dyscognitive seizures 15.37 10.07 6 898541 3843 109686909
Lymphocyte count abnormal 15.33 10.07 49 898498 2377 109688375
Granuloma 15.27 10.07 34 898513 9456 109681296
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.25 10.07 96 898451 6248 109684504
Groin pain 15.16 10.07 69 898478 15359 109675393
Invasive ductal breast carcinoma 15.15 10.07 19 898528 6627 109684125
Product adhesion issue 15.13 10.07 3 898544 3003 109687749
Urine analysis abnormal 15.13 10.07 102 898445 6795 109683957
Transfusion-related circulatory overload 15.13 10.07 27 898520 894 109689858
Blood phosphorus increased 15.13 10.07 201 898346 16139 109674613
Hip fracture 15.07 10.07 198 898349 34953 109655799
Nasal septum perforation 15.07 10.07 27 898520 897 109689855
Urinary incontinence 15.03 10.07 291 898256 48296 109642456
Gastritis 15.01 10.07 327 898220 53372 109637380
Atypical femur fracture 15.01 10.07 17 898530 6202 109684550
Migraine 15 10.07 1604 896943 170048 109520704
Adrenal insufficiency 14.97 10.07 248 898299 42142 109648610
Therapeutic response shortened 14.96 10.07 330 898217 29253 109661499
Gastrointestinal pain 14.91 10.07 48 898499 11812 109678940
Sphincter of Oddi dysfunction 14.87 10.07 21 898526 567 109690185
Emotional disorder 14.87 10.07 74 898473 16086 109674666
Granulomatosis with polyangiitis 14.86 10.07 62 898485 3428 109687324
Petit mal epilepsy 14.81 10.07 24 898523 7523 109683229
Pulmonary toxicity 14.81 10.07 84 898463 17662 109673090
Dyslipidaemia 14.75 10.07 73 898474 15892 109674860
Haemolysis 14.74 10.07 193 898354 15446 109675306
Complication associated with device 14.68 10.07 99 898448 19974 109670778
Tongue biting 14.66 10.07 3 898544 2936 109687816
Neonatal respiratory distress syndrome 14.66 10.07 17 898530 375 109690377
Skin weeping 14.62 10.07 6 898541 3729 109687023
Intermenstrual bleeding 14.62 10.07 21 898526 6913 109683839
Osteolysis 14.57 10.07 14 898533 5509 109685243
Thrombotic thrombocytopenic purpura 14.54 10.07 22 898525 7089 109683663
Prescribed overdose 14.51 10.07 860 897687 86721 109604031
Vein rupture 14.48 10.07 50 898497 2525 109688227
Reversible airways obstruction 14.47 10.07 49 898498 2450 109688302
Mental impairment 14.47 10.07 116 898431 22523 109668229
Weight decreased 14.45 10.07 3477 895070 464580 109226172
Facial paresis 14.44 10.07 17 898530 6096 109684656
Bone lesion 14.42 10.07 22 898525 7065 109683687
Dystonia 14.37 10.07 137 898410 25668 109665084
Tumour marker increased 14.34 10.07 12 898535 5048 109685704
Renal failure neonatal 14.32 10.07 9 898538 81 109690671
Mycobacterium avium complex infection 14.26 10.07 16 898531 5861 109684891
Urinary retention 14.26 10.07 444 898103 69239 109621513
Plasma cell myeloma recurrent 14.19 10.07 22 898525 7020 109683732
Focal segmental glomerulosclerosis 14.18 10.07 8 898539 4137 109686615
Adenovirus infection 14.17 10.07 44 898503 10950 109679802
Pregnancy with contraceptive device 14.16 10.07 7 898540 3900 109686852
Stenotrophomonas infection 14.15 10.07 16 898531 5842 109684910
Unmasking of previously unidentified disease 14.15 10.07 3 898544 2865 109687887
Liver disorder 14.13 10.07 1341 897206 140902 109549850
Extrapyramidal disorder 14.13 10.07 158 898389 28709 109662043
Polyarthritis 14.13 10.07 93 898454 18870 109671882
Unintended pregnancy 14.13 10.07 11 898536 4797 109685955
Lactic acidosis 14.12 10.07 613 897934 92198 109598554
Drug tolerance 14.11 10.07 78 898469 16507 109674245
Disseminated intravascular coagulation 14.11 10.07 243 898304 41043 109649709
Progressive multifocal leukoencephalopathy 14.11 10.07 132 898415 24824 109665928
Knee operation 14.09 10.07 22 898525 7000 109683752
Bacterial test positive 14.08 10.07 112 898435 7865 109682887
Chest pain 14.06 10.07 2770 895777 373605 109317147
Loss of libido 14.05 10.07 4 898543 3129 109687623
Bradycardia neonatal 14.05 10.07 9 898538 84 109690668
Specific gravity urine abnormal 14.05 10.07 9 898538 84 109690668
Post cholecystectomy syndrome 14.03 10.07 25 898522 827 109689925
Lymphoma 14.00 10.07 101 898446 20070 109670682
Cardiac dysfunction 13.97 10.07 18 898529 6205 109684547
Monoparesis 13.91 10.07 10 898537 4543 109686209
Psychotic symptom 13.91 10.07 7 898540 3860 109686892
Neuroblastoma 13.90 10.07 16 898531 350 109690402
Acute fatty liver of pregnancy 13.88 10.07 7 898540 39 109690713
Goitre 13.87 10.07 18 898529 6186 109684566
Leukocytosis 13.87 10.07 552 897995 53276 109637476
Central nervous system lesion 13.87 10.07 72 898475 15481 109675271
Smear cervix abnormal 13.83 10.07 51 898496 2661 109688091
Right ventricle outflow tract obstruction 13.83 10.07 8 898539 61 109690691
Concomitant disease progression 13.81 10.07 6 898541 3604 109687148
Renal cell carcinoma 13.81 10.07 25 898522 7505 109683247
Tetany 13.77 10.07 6 898541 3598 109687154
Soft tissue disorder 13.77 10.07 61 898486 3463 109687289
Left ventricular hypertrophy 13.76 10.07 58 898489 13186 109677566
Culture urine positive 13.74 10.07 76 898471 4720 109686032
Drooling 13.73 10.07 23 898524 7116 109683636
Systemic mycosis 13.67 10.07 7 898540 3822 109686930
Therapy non-responder 13.66 10.07 1096 897451 156211 109534541
Blood test abnormal 13.65 10.07 316 898231 28238 109662514
Respiratory disorder 13.60 10.07 710 897837 70672 109620080
Essential hypertension 13.56 10.07 27 898520 7820 109682932
Nodule 13.56 10.07 185 898362 32446 109658306
Exposed bone in jaw 13.56 10.07 7 898540 3804 109686948
Substance abuser 13.52 10.07 18 898529 459 109690293
Bronchial disorder 13.50 10.07 3 898544 2773 109687979
Libido decreased 13.50 10.07 17 898530 5918 109684834
Frostbite 13.47 10.07 14 898533 272 109690480
Alcohol poisoning 13.46 10.07 122 898425 8898 109681854
Tooth extraction 13.43 10.07 57 898490 12934 109677818
Injection site vesicles 13.43 10.07 10 898537 4461 109686291
Thyroid neoplasm 13.42 10.07 5 898542 3296 109687456
Hypokinesia 13.42 10.07 113 898434 21713 109669039
Premature delivery 13.34 10.07 172 898375 30460 109660292
Retinal vein occlusion 13.33 10.07 8 898539 3999 109686753
Vanishing bile duct syndrome 13.27 10.07 56 898491 3112 109687640
Lung transplant 13.26 10.07 14 898533 5272 109685480
Incorrect dosage administered 13.24 10.07 65 898482 3853 109686899
Thoracic vertebral fracture 13.21 10.07 21 898526 6634 109684118
Blood immunoglobulin G decreased 13.16 10.07 82 898465 5318 109685434
Diabetic nephropathy 13.15 10.07 6 898541 3502 109687250
Drug level below therapeutic 13.15 10.07 149 898398 11524 109679228
Productive cough 13.15 10.07 777 897770 113528 109577224
Peritonitis 13.14 10.07 186 898361 32421 109658331
Granulocyte count decreased 13.13 10.07 8 898539 3966 109686786
Stress cardiomyopathy 13.09 10.07 75 898472 15731 109675021
Encephalopathy 13.07 10.07 794 897753 80261 109610491
Left ventricular failure 13.03 10.07 48 898499 11341 109679411
Toxoplasmosis 13.01 10.07 5 898542 3234 109687518
Haematemesis 12.99 10.07 373 898174 58735 109632017
Photosensitivity reaction 12.95 10.07 139 898408 25450 109665302
Food allergy 12.93 10.07 231 898316 19717 109671035
Product residue present 12.93 10.07 8 898539 3933 109686819
Supraventricular extrasystoles 12.93 10.07 29 898518 8044 109682708
Dysarthria 12.92 10.07 555 897992 83566 109607186
Thyroid cancer 12.92 10.07 19 898528 6195 109684557
Therapy change 12.89 10.07 40 898507 9957 109680795
Application site pruritus 12.89 10.07 9 898538 4151 109686601
Nitrite urine present 12.89 10.07 30 898517 1205 109689547
Disorientation 12.88 10.07 457 898090 70214 109620538
Creatinine renal clearance increased 12.87 10.07 61 898486 3564 109687188
Juvenile idiopathic arthritis 12.85 10.07 18 898529 5989 109684763
Sensitisation 12.84 10.07 9 898538 4142 109686610
Glucose-6-phosphate dehydrogenase deficiency 12.83 10.07 18 898529 483 109690269
Alpha 1 microglobulin increased 12.83 10.07 7 898540 47 109690705
Hyperprolactinaemia 12.82 10.07 21 898526 6554 109684198
Gastritis erosive 12.81 10.07 52 898495 11948 109678804
Systemic candida 12.80 10.07 40 898507 9934 109680818
Extra dose administered 12.79 10.07 53 898494 12106 109678646
Respiratory alkalosis 12.79 10.07 85 898462 5636 109685116
Walking aid user 12.77 10.07 280 898267 24795 109665957
Hyperaesthesia 12.75 10.07 179 898368 14548 109676204
Blindness unilateral 12.73 10.07 39 898508 9747 109681005
Long QT syndrome 12.73 10.07 24 898523 7094 109683658
Cholestatic liver injury 12.71 10.07 103 898444 7273 109683479
Miosis 12.68 10.07 250 898297 21733 109669019
Disseminated cryptococcosis 12.67 10.07 3 898544 2654 109688098
Pain of skin 12.63 10.07 103 898444 19926 109670826
Nasal oedema 12.61 10.07 97 898450 6742 109684010
Herpes zoster 12.59 10.07 736 897811 107643 109583109
Hyperphosphataemia 12.57 10.07 195 898352 16186 109674566
Gait inability 12.57 10.07 1279 897268 135097 109555655
Abdominal pain lower 12.56 10.07 220 898327 37063 109653689
Enuresis 12.51 10.07 9 898538 4087 109686665
Apparent death 12.48 10.07 4 898543 2898 109687854
Pneumonia aspiration 12.47 10.07 536 898011 80697 109610055
Renal mass 12.46 10.07 7 898540 3628 109687124
Urinary casts 12.45 10.07 31 898516 1301 109689451
Haemoglobin urine present 12.43 10.07 25 898522 907 109689845
Interleukin level increased 12.38 10.07 35 898512 1586 109689166
Porphyria acute 12.36 10.07 218 898329 18562 109672190
Pleuritic pain 12.34 10.07 192 898355 15948 109674804
Musculoskeletal disorder 12.34 10.07 121 898426 22543 109668209
Caesarean section 12.30 10.07 64 898483 13753 109676999
Intervertebral disc protrusion 12.25 10.07 155 898392 27543 109663209
Allodynia 12.20 10.07 41 898506 2042 109688710
Metastasis 12.20 10.07 31 898516 8236 109682516
Adverse reaction 12.20 10.07 321 898226 29273 109661479
Skin swelling 12.16 10.07 30 898517 8050 109682702
Nasal obstruction 12.15 10.07 6 898541 3344 109687408
Severe invasive streptococcal infection 12.14 10.07 7 898540 53 109690699
Dependent personality disorder 12.11 10.07 9 898538 109 109690643
Anti factor V antibody 12.10 10.07 14 898533 308 109690444
Serum sickness 12.08 10.07 69 898478 4337 109686415
Hepatitis toxic 12.07 10.07 86 898461 5835 109684917
Foreign body sensation in eyes 12.05 10.07 6 898541 3328 109687424
Orbital compartment syndrome 12.05 10.07 9 898538 110 109690642
Aneurysm 12.05 10.07 11 898536 4435 109686317
Diarrhoea haemorrhagic 12.01 10.07 76 898471 15563 109675189
Haemorrhagic diathesis 12.00 10.07 27 898520 7481 109683271
Bone marrow disorder 11.98 10.07 10 898537 4213 109686539
Infusion site haemorrhage 11.95 10.07 71 898476 4527 109686225
Ophthalmoplegia 11.93 10.07 7 898540 3543 109687209
Eosinophil percentage increased 11.93 10.07 34 898513 1548 109689204
Aminoaciduria 11.92 10.07 15 898532 361 109690391
Teething 11.92 10.07 10 898537 146 109690606
Pseudomonas infection 11.90 10.07 157 898390 27696 109663056
Pulmonary thrombosis 11.90 10.07 65 898482 13798 109676954
Mechanical ventilation complication 11.90 10.07 22 898525 749 109690003
Abortion induced 11.89 10.07 30 898517 7989 109682763
Dysphagia 11.87 10.07 1080 897467 152520 109538232
Enterobacter infection 11.86 10.07 18 898529 5793 109684959
Musculoskeletal discomfort 11.85 10.07 128 898419 23410 109667342
Diffuse large B-cell lymphoma 11.83 10.07 78 898469 15820 109674932
Mean cell haemoglobin concentration increased 11.81 10.07 27 898520 1072 109689680
Inflammatory marker increased 11.80 10.07 69 898478 14400 109676352
Band neutrophil count increased 11.80 10.07 21 898526 694 109690058
Base excess 11.72 10.07 7 898540 57 109690695
Infusion site discharge 11.70 10.07 39 898508 1934 109688818
Brain natriuretic peptide increased 11.70 10.07 49 898498 11160 109679592
Diffuse large B-cell lymphoma refractory 11.70 10.07 46 898501 2475 109688277
Panic attack 11.69 10.07 165 898382 28775 109661977
Catheter management 11.68 10.07 8 898539 3727 109687025
Hair texture abnormal 11.68 10.07 9 898538 3945 109686807
Acute psychosis 11.64 10.07 14 898533 4973 109685779
Hepatic cyst 11.63 10.07 29 898518 7754 109682998
Psychiatric decompensation 11.63 10.07 18 898529 5747 109685005
Gingival bleeding 11.62 10.07 104 898443 19735 109671017
Orthopnoea 11.62 10.07 48 898499 10973 109679779
Immunosuppressant drug level decreased 11.60 10.07 4 898543 2767 109687985
Pneumonia bacterial 11.60 10.07 147 898400 26114 109664638
Transferrin decreased 11.60 10.07 18 898529 530 109690222
Organising pneumonia 11.57 10.07 68 898479 14175 109676577
Pleurothotonus 11.56 10.07 3 898544 2495 109688257
Hyperglycaemic hyperosmolar nonketotic syndrome 11.51 10.07 5 898542 3004 109687748
Encephalitis viral 11.50 10.07 5 898542 3002 109687750
Osteopenia 11.50 10.07 120 898427 22089 109668663
Monocyte percentage increased 11.49 10.07 43 898504 2260 109688492
Lung opacity 11.49 10.07 145 898402 11507 109679245
Fatigue 11.47 10.07 9410 889137 1206548 108484204
Cardiac tamponade 11.45 10.07 50 898497 11257 109679495
Lymphangiosis carcinomatosa 11.45 10.07 3 898544 2479 109688273
Haemorrhage intracranial 11.41 10.07 166 898381 28803 109661949
Lacunar infarction 11.41 10.07 21 898526 6265 109684487
Enteritis 11.41 10.07 100 898447 19056 109671696
Ejection fraction abnormal 11.38 10.07 7 898540 3453 109687299
Adverse drug reaction 11.37 10.07 1001 897546 104558 109586194
Aphasia 11.33 10.07 379 898168 58618 109632134
Arteriospasm coronary 11.32 10.07 37 898510 9063 109681689
Epidermal necrosis 11.32 10.07 52 898495 2998 109687754
Angina pectoris 11.31 10.07 403 898144 61892 109628860
Atypical mycobacterial infection 11.25 10.07 4 898543 2714 109688038
Stoma site dermatitis 11.23 10.07 13 898534 286 109690466
Rheumatoid nodule 11.20 10.07 108 898439 20188 109670564
Nephrogenic diabetes insipidus 11.20 10.07 3 898544 2442 109688310
Clostridium difficile infection 11.19 10.07 330 898217 51799 109638953
Lymphadenopathy mediastinal 11.18 10.07 17 898530 5467 109685285
Hepatic perfusion disorder 11.14 10.07 7 898540 63 109690689
Intentional product misuse to child 11.12 10.07 11 898536 201 109690551
Allergy to chemicals 11.12 10.07 55 898492 3270 109687482
Prothrombin time abnormal 11.11 10.07 29 898518 1253 109689499
Cystitis 11.05 10.07 649 897898 65387 109625365
Postmortem blood drug level increased 11.03 10.07 28 898519 1189 109689563
Trichoglossia 11.02 10.07 23 898524 857 109689895
Lung adenocarcinoma 11.02 10.07 40 898507 9491 109681261
Dermatitis exfoliative 11 10.07 51 898496 11296 109679456
Multiple organ dysfunction syndrome 10.97 10.07 1072 897475 150638 109540114
Extrasystoles 10.93 10.07 33 898514 8285 109682467
Angiokeratoma 10.90 10.07 11 898536 206 109690546
Kussmaul respiration 10.90 10.07 16 898531 448 109690304
Pre-eclampsia 10.88 10.07 35 898512 8615 109682137
Obstructive defaecation 10.88 10.07 12 898535 250 109690502
Type I hypersensitivity 10.87 10.07 89 898458 6304 109684448
Urine bilirubin increased 10.87 10.07 9 898538 129 109690623
Metastases to peritoneum 10.86 10.07 18 898529 5592 109685160
Erythema annulare 10.85 10.07 13 898534 297 109690455
Premature rupture of membranes 10.84 10.07 13 898534 4624 109686128
Portal hypertension 10.83 10.07 35 898512 8602 109682150
Skin mass 10.82 10.07 42 898505 9774 109680978
Obsessive-compulsive disorder 10.81 10.07 27 898520 7214 109683538
Fibrin D dimer increased 10.79 10.07 125 898422 9720 109681032
Extremity necrosis 10.79 10.07 9 898538 3793 109686959
Red blood cell count decreased 10.75 10.07 432 898115 65491 109625261
Chondropathy 10.73 10.07 5 898542 2882 109687870
Acinetobacter infection 10.72 10.07 8 898539 3565 109687187
Necrotic lymphadenopathy 10.69 10.07 11 898536 211 109690541
Hypotensive crisis 10.69 10.07 10 898537 170 109690582
Pneumocystis jirovecii infection 10.65 10.07 12 898535 4388 109686364
Specific gravity urine increased 10.65 10.07 17 898530 513 109690239
Acute graft versus host disease in liver 10.60 10.07 3 898544 2356 109688396
Nightmare 10.59 10.07 401 898146 38462 109652290
Metabolic myopathy 10.59 10.07 9 898538 134 109690618
Blood urine present 10.59 10.07 265 898282 23980 109666772
Urobilinogen urine increased 10.59 10.07 19 898528 632 109690120
Electrocardiogram abnormal 10.56 10.07 99 898448 18610 109672142
Internal haemorrhage 10.53 10.07 44 898503 10027 109680725
Injection site inflammation 10.51 10.07 14 898533 4757 109685995
Blood glucose fluctuation 10.51 10.07 30 898517 7668 109683084
Sinus congestion 10.51 10.07 323 898224 30136 109660616
Impulsive behaviour 10.50 10.07 7 898540 3308 109687444
Carotid artery occlusion 10.50 10.07 41 898506 9524 109681228
Pancreatic carcinoma metastatic 10.47 10.07 11 898536 4153 109686599
Hyperphagia 10.47 10.07 8 898539 3523 109687229
Haematoma 10.46 10.07 379 898168 58097 109632655
Urine oxalate increased 10.45 10.07 11 898536 217 109690535
Injection site haematoma 10.44 10.07 16 898531 5130 109685622
Sinus node dysfunction 10.44 10.07 38 898509 9009 109681743
Sinobronchitis 10.44 10.07 16 898531 466 109690286
Blood bilirubin increased 10.41 10.07 734 897813 75238 109615514
Oesophageal varices haemorrhage 10.40 10.07 15 898532 4930 109685822
Agonal respiration 10.39 10.07 13 898534 311 109690441
Blepharitis 10.39 10.07 13 898534 4539 109686213
Ear infection 10.39 10.07 616 897931 62116 109628636
Drug-disease interaction 10.38 10.07 37 898510 1899 109688853
Snoring 10.36 10.07 25 898522 6759 109683993
Growth retardation 10.35 10.07 4 898543 2578 109688174
Pulmonary arterial pressure increased 10.35 10.07 16 898531 5111 109685641
Endocarditis enterococcal 10.34 10.07 14 898533 363 109690389
Adrenergic syndrome 10.34 10.07 12 898535 265 109690487
Carcinoembryonic antigen increased 10.33 10.07 5 898542 2819 109687933
Pneumonia cytomegaloviral 10.32 10.07 26 898521 6928 109683824
Ankle fracture 10.29 10.07 107 898440 19712 109671040
Oral discomfort 10.29 10.07 52 898495 11259 109679493
Hip surgery 10.29 10.07 11 898536 4119 109686633
Alanine aminotransferase abnormal 10.25 10.07 40 898507 9294 109681458
Acid-base balance disorder mixed 10.24 10.07 8 898539 105 109690647
Expired product administered 10.24 10.07 34 898513 8286 109682466
Cold sweat 10.23 10.07 122 898425 21909 109668843
Thyroiditis 10.21 10.07 24 898523 6549 109684203
Post-traumatic neck syndrome 10.20 10.07 45 898502 2550 109688202
Diastolic dysfunction 10.19 10.07 59 898488 12345 109678407
Biliary ischaemia 10.18 10.07 8 898539 106 109690646
Fanconi syndrome acquired 10.17 10.07 6 898541 3028 109687724
Performance status decreased 10.15 10.07 28 898519 7238 109683514
Sleep disorder therapy 10.13 10.07 99 898448 7372 109683380
Rhabdomyolysis 10.13 10.07 841 897706 119560 109571192
Myelocyte percentage increased 10.10 10.07 11 898536 226 109690526
Hysterectomy 10.09 10.07 33 898514 8081 109682671
Immune-mediated myositis 10.09 10.07 22 898525 6164 109684588
Drug therapy 10.07 10.07 97 898450 7194 109683558
Haemophagocytic lymphohistiocytosis 10.07 10.07 188 898359 31371 109659381

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental overdose 27.37 18.14 14 578 136 113225
Gastrointestinal necrosis 20.43 18.14 9 583 60 113301

Pharmacologic Action:

SourceCodeDescription
ATC R06AA09 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
ATC R06AA59 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
FDA MoA N0000000207 Histamine Receptor Antagonists
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018494 Histamine Agents
MeSH PA D000932 Antiemetics
MeSH PA D005765 Gastrointestinal Agents
FDA EPC N0000175750 Antihistamine
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48873 cholinergic antagonist
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:35441 antiinfective agent

Related Drugs by ATC class:

R06AA Aminoalkyl ethers 8 drugs
bromazinecarbinoxaminechlorphenoxamineclemastinedimenhydrinatediphenhydraminediphenylpyralinetrimethobenzamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Morning sickness off-label use 51885006
Ocular hypertension contraindication 4210003 DOID:9282
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Arterial thrombosis contraindication 65198009
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Antihistaminic therapy Indication
Dogs Antihistaminic therapy Indication
Horses Antihistaminic therapy Indication

🐶 Veterinary products

ProductApplicantIngredients
A-H-Tablets 100 mg, A-H-Tablets 25 mg Intervet Inc. 1
A-H Injection Intervet Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.83 Basic
pKa2 4.29 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9089489 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9375404 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9526703 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9937132 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019738 VUID
N0000147830 NUI
D02327 KEGG_DRUG
562-10-7 SECONDARY_CAS_RN
4019049 VANDF
4019738 VANDF
C0013092 UMLSCUI
CHEBI:51380 CHEBI
CHEMBL1004 ChEMBL_ID
CHEMBL1200392 ChEMBL_ID
DB00366 DRUGBANK_ID
D004319 MESH_DESCRIPTOR_UI
3162 PUBCHEM_CID
7171 IUPHAR_LIGAND_ID
C035385 MESH_SUPPLEMENTAL_RECORD_UI
1782 INN_ID
95QB77JKPL UNII
23665 RXNORM
10000 MMSL
4644 MMSL
d03154 MMSL
003372 NDDF
004789 NDDF
412380009 SNOMEDCT_US
44068004 SNOMEDCT_US
95QB77JKPL INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8718 SOLUTION 12.50 mg ORAL OTC Monograph Drug 17 sections
Robitussin Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8718 SOLUTION 12.50 mg ORAL OTC Monograph Drug 17 sections
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime HUMAN OTC DRUG LABEL 3 0031-8744 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 17 sections
Robitussin Honey Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8758 SOLUTION 12.50 mg ORAL OTC Monograph Drug 17 sections
Childrens Robitussin Honey Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8762 SOLUTION 6.25 mg ORAL OTC Monograph Drug 17 sections
ROBITUSSIN Nighttime Cough DM Soft CHEWS HUMAN OTC DRUG LABEL 2 0031-9311 TABLET, CHEWABLE 6.25 mg ORAL OTC Monograph Drug 17 sections
Good Sense Severe NightTime HUMAN OTC DRUG LABEL 4 0113-0019 SOLUTION 12.50 mg ORAL OTC Monograph Drug 16 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0056 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 15 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0335 SOLUTION 12.50 mg ORAL OTC Monograph Drug 16 sections
Good sense sleep aid HUMAN OTC DRUG LABEL 1 0113-0441 TABLET 25 mg ORAL ANDA 16 sections
good sense nighttime HUMAN OTC DRUG LABEL 3 0113-0459 SOLUTION 12.50 mg ORAL OTC Monograph Drug 16 sections
Good Sense Severe NightTime Cold and Flu HUMAN OTC DRUG LABEL 4 0113-0763 SOLUTION 12.50 mg ORAL OTC Monograph Drug 16 sections
good sense night time cold and flu HUMAN OTC DRUG LABEL 4 0113-2501 SOLUTION 6.25 mg ORAL OTC Monograph Drug 16 sections
good sense sleep aid ultra HUMAN OTC DRUG LABEL 1 0113-4032 TABLET, COATED 25 mg ORAL ANDA 16 sections
GOOD SENSE NIGHT TIME HUMAN OTC DRUG LABEL 3 0113-6012 SOLUTION 6.25 mg ORAL OTC Monograph Drug 16 sections
good sense sleep aid ultra HUMAN OTC DRUG LABEL 1 0113-6044 TABLET 25 mg ORAL ANDA 16 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 6.25 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Severe Cold Night PowerFast Fizz HUMAN OTC DRUG LABEL 4 0280-0068 TABLET, EFFERVESCENT 6.25 mg ORAL OTC Monograph Drug 16 sections
Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels HUMAN OTC DRUG LABEL 4 0280-0097 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 16 sections
Alka-Seltzer Plus Night Severe Cold and Flu HUMAN OTC DRUG LABEL 4 0280-0922 POWDER, FOR SOLUTION 12.50 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Cold Night HUMAN OTC DRUG LABEL 4 0280-1545 TABLET, EFFERVESCENT 6.25 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Maximum Strength Night Cold and Flu HUMAN OTC DRUG LABEL 4 0280-1600 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough HUMAN OTC DRUG LABEL 4 0280-1620 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 17 sections
Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels HUMAN OTC DRUG LABEL 4 0280-1640 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 16 sections
ALKA SELTZER COLD Cold and Flu plus Congestion Severe Fast Hot Liquid Night HUMAN OTC DRUG LABEL 4 0280-8272 POWDER, FOR SOLUTION 12.50 mg ORAL OTC Monograph Drug 17 sections
ALKA SELTZER COLD Cold and Allergy Maximum Strength Fast Gels HUMAN OTC DRUG LABEL 4 0280-8276 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 16 sections
ALKA SELTZER COLD Cold Flu and Congestion Severe Night Fast Gels HUMAN OTC DRUG LABEL 4 0280-8282 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC Monograph Drug 16 sections
Night Time Severe Cold and Flu HUMAN OTC DRUG LABEL 4 0363-0331 LIQUID 12.50 mg ORAL OTC Monograph Drug 16 sections
Sleep Aid HUMAN OTC DRUG LABEL 1 0363-0386 TABLET 25 mg ORAL ANDA 16 sections
Cold and Flu HUMAN OTC DRUG LABEL 3 0363-0401 SOLUTION 12.50 mg ORAL OTC Monograph Drug 16 sections