AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
dimethyl sulfoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 906 | 67-68-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 51 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AXL,BRAF,CDK9,DDR1,DYRK1B,GRK2,MAPK7,PRKDC,STK33 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 22, 2021 | PMDA | Kyorin Pharmaceutical Co Ltd | |
| April 4, 1978 | FDA | MYLAN INSTITUTIONAL |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G04BX13 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals |
| ATC | M02AX03 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Other topical products for joint and muscular pain |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D003451 | Cryoprotective Agents |
| MeSH PA | D012997 | Solvents |
| MeSH PA | D016166 | Free Radical Scavengers |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:22333 | alkylating agent |
| CHEBI has role | CHEBI:35481 | non-narcotic analgesic |
| CHEBI has role | CHEBI:37335 | MRI contrast agent |
| CHEBI has role | CHEBI:48358 | polar aprotic solvent |
| CHEBI has role | CHEBI:48578 | radical scavenger |
| CHEBI has role | CHEBI:50247 | antidote |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:176497 | geroprotector |
Related Drugs by ATC class:
G04BX Other urologicals 10 drugs
M02AX Other topical products for joint and muscular pain 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ulcerative cystitis | indication | 111409009 | DOID:13949 |
| Improvement of symptoms in patients with interstitial cystitis | indication | 197834003 | DOID:1678 |
| Disorder of lens | contraindication | 10810001 | DOID:110 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Malignant tumor of urinary tract proper | contraindication | 363517008 | |
| Urinary Burning Sensation | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Acute swelling caused by trauma | Indication |
| Horses | Acute swelling caused by trauma | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Domoso Solution | Zoetis Inc. | 1 |
| Synotic Otic Solution | Zoetis Inc. | 2 |
| Synsac Solution | Zoetis Inc. | 2 |
| Domoso Gel | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cereblon isoform 4 | Cytosolic other | Ki | 4.97 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| YOW8V9698H | UNII |
| 4019027 | VUID |
| N0000147300 | NUI |
| D01043 | KEGG_DRUG |
| 3455 | RXNORM |
| 4019027 | VANDF |
| C0012403 | UMLSCUI |
| CHEBI:28262 | CHEBI |
| DMS | PDB_CHEM_ID |
| CHEMBL504 | ChEMBL_ID |
| 679 | PUBCHEM_CID |
| DB01093 | DRUGBANK_ID |
| D004121 | MESH_DESCRIPTOR_UI |
| 2023 | INN_ID |
| 1614 | MMSL |
| 4608 | MMSL |
| d01431 | MMSL |
| 002883 | NDDF |
| 115535002 | SNOMEDCT_US |
| 346400003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| RIMSO-50 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-177 | IRRIGANT | 0.54 g | INTRAVESICAL | NDA | 15 sections |
| Dimethyl Sulfoxide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 84897-052 | IRRIGANT | 0.54 g | INTRAVESICAL | ANDA | 15 sections |