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castor oil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5661 | 8001-79-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 54 | |||
| kinase-selectivity-class | AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,PDK4,PLK1,STK33,TEK | 10 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 1210.59 | 33.99 | 345 | 8994 | 37625 | 90581483 |
| Chronic sinusitis | 541.78 | 33.99 | 167 | 9172 | 23635 | 90595473 |
| Paraesthesia oral | 436.35 | 33.99 | 152 | 9187 | 31507 | 90587601 |
| Vaginal flatulence | 402.29 | 33.99 | 115 | 9224 | 12523 | 90606585 |
| Sedation complication | 381.65 | 33.99 | 118 | 9221 | 16826 | 90602282 |
| Proctitis | 380.88 | 33.99 | 115 | 9224 | 15144 | 90603964 |
| Creatinine renal clearance decreased | 377.21 | 33.99 | 120 | 9219 | 18779 | 90600329 |
| Constipation | 374.51 | 33.99 | 274 | 9065 | 280121 | 90338987 |
| Female genital tract fistula | 371.31 | 33.99 | 117 | 9222 | 17751 | 90601357 |
| Procedural pain | 364.89 | 33.99 | 135 | 9204 | 33225 | 90585883 |
| Radiculopathy | 359.03 | 33.99 | 115 | 9224 | 18390 | 90600718 |
| Vaginal discharge | 353.32 | 33.99 | 115 | 9224 | 19349 | 90599759 |
| Blood calcium decreased | 318.52 | 33.99 | 119 | 9220 | 30063 | 90589045 |
| Oral candidiasis | 285.98 | 33.99 | 115 | 9224 | 35340 | 90583768 |
| Orthostatic hypotension | 280.88 | 33.99 | 119 | 9220 | 41708 | 90577400 |
| Sedation | 267.91 | 33.99 | 120 | 9219 | 48051 | 90571057 |
| Depressed level of consciousness | 246.29 | 33.99 | 129 | 9210 | 72655 | 90546453 |
| Colitis | 239.61 | 33.99 | 125 | 9214 | 69817 | 90549291 |
| Frequent bowel movements | 236.69 | 33.99 | 116 | 9223 | 56819 | 90562289 |
| Colitis ulcerative | 233.38 | 33.99 | 117 | 9222 | 60149 | 90558959 |
| Cognitive disorder | 231.93 | 33.99 | 122 | 9217 | 69285 | 90549823 |
| Haematochezia | 226.64 | 33.99 | 121 | 9218 | 70792 | 90548316 |
| Rectal haemorrhage | 203.86 | 33.99 | 119 | 9220 | 82625 | 90536483 |
| Therapeutic product effect incomplete | 193.91 | 33.99 | 160 | 9179 | 193736 | 90425372 |
| Balance disorder | 191.30 | 33.99 | 121 | 9218 | 96959 | 90522149 |
| Renal function test abnormal | 165.69 | 33.99 | 51 | 9288 | 7140 | 90611968 |
| Creatinine renal clearance increased | 160.96 | 33.99 | 42 | 9297 | 3239 | 90615869 |
| Dyspepsia | 154.60 | 33.99 | 142 | 9197 | 198018 | 90421090 |
| Erythema | 129.90 | 33.99 | 138 | 9201 | 229108 | 90390000 |
| Drug ineffective | 119.45 | 33.99 | 361 | 8978 | 1383937 | 89235171 |
| Weight decreased | 118.23 | 33.99 | 169 | 9170 | 379741 | 90239367 |
| Abdominal pain | 110.08 | 33.99 | 167 | 9172 | 395554 | 90223554 |
| Pain | 105.30 | 33.99 | 280 | 9059 | 996061 | 89623047 |
| Multiple drug therapy | 101.61 | 33.99 | 35 | 9304 | 6974 | 90612134 |
| Mobility decreased | 93.70 | 33.99 | 122 | 9217 | 250612 | 90368496 |
| Anaemia | 87.06 | 33.99 | 141 | 9198 | 352661 | 90266447 |
| Toxicity to various agents | 79.23 | 33.99 | 121 | 9218 | 287725 | 90331383 |
| Malaise | 77.76 | 33.99 | 180 | 9159 | 585806 | 90033302 |
| Hypotension | 77.48 | 33.99 | 128 | 9211 | 325269 | 90293839 |
| Pyrexia | 73.92 | 33.99 | 190 | 9149 | 660295 | 89958813 |
| Infusion related reaction | 70.08 | 33.99 | 141 | 9198 | 416639 | 90202469 |
| Off label use | 57.08 | 33.99 | 244 | 9095 | 1102008 | 89517100 |
| Fatigue | 55.41 | 33.99 | 25 | 9314 | 1153998 | 89465110 |
| Condition aggravated | 46.62 | 33.99 | 4 | 9335 | 595541 | 90023567 |
| Drug abuse | 45.49 | 33.99 | 49 | 9290 | 82298 | 90536810 |
| Fall | 45.13 | 33.99 | 130 | 9209 | 481680 | 90137428 |
| Rash | 36.96 | 33.99 | 18 | 9321 | 796082 | 89823026 |
| Joint swelling | 35.29 | 33.99 | 5 | 9334 | 503295 | 90115813 |
| Abdominal discomfort | 35.26 | 33.99 | 4 | 9335 | 477324 | 90141784 |
| Overdose | 34.72 | 33.99 | 60 | 9279 | 157649 | 90461459 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Injection related reaction | 57.84 | 22.29 | 12 | 2466 | 604 | 42618253 |
| Volvulus | 34.62 | 22.29 | 10 | 2468 | 2003 | 42616854 |
| Skin reaction | 32.35 | 22.29 | 13 | 2465 | 7054 | 42611803 |
| Oesophageal injury | 30.95 | 22.29 | 6 | 2472 | 213 | 42618644 |
| Pneumonia aspiration | 25.48 | 22.29 | 22 | 2456 | 50056 | 42568801 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Chronic sinusitis | 526.73 | 25.82 | 165 | 11079 | 24919 | 110553136 |
| Macular degeneration | 511.89 | 25.82 | 156 | 11088 | 21503 | 110556552 |
| Paraesthesia oral | 421.38 | 25.82 | 150 | 11094 | 33521 | 110544534 |
| Vaginal flatulence | 403.69 | 25.82 | 114 | 11130 | 12030 | 110566025 |
| Female genital tract fistula | 377.53 | 25.82 | 116 | 11128 | 16403 | 110561652 |
| Proctitis | 374.74 | 25.82 | 116 | 11128 | 16811 | 110561244 |
| Sedation complication | 372.84 | 25.82 | 120 | 11124 | 19735 | 110558320 |
| Creatinine renal clearance decreased | 369.76 | 25.82 | 122 | 11122 | 21693 | 110556362 |
| Constipation | 368.19 | 25.82 | 298 | 10946 | 357488 | 110220567 |
| Vaginal discharge | 359.99 | 25.82 | 114 | 11130 | 17794 | 110560261 |
| Procedural pain | 354.45 | 25.82 | 134 | 11110 | 35431 | 110542624 |
| Radiculopathy | 351.39 | 25.82 | 114 | 11130 | 19222 | 110558833 |
| Blood calcium decreased | 317.65 | 25.82 | 124 | 11120 | 35721 | 110542334 |
| Oral candidiasis | 264.74 | 25.82 | 116 | 11128 | 44644 | 110533411 |
| Orthostatic hypotension | 241.62 | 25.82 | 123 | 11121 | 66126 | 110511929 |
| Sedation | 232.89 | 25.82 | 122 | 11122 | 69561 | 110508494 |
| Cognitive disorder | 214.82 | 25.82 | 125 | 11119 | 87386 | 110490669 |
| Depressed level of consciousness | 213.07 | 25.82 | 136 | 11108 | 112142 | 110465913 |
| Frequent bowel movements | 210.49 | 25.82 | 115 | 11129 | 71275 | 110506780 |
| Colitis ulcerative | 204.55 | 25.82 | 116 | 11128 | 77247 | 110500808 |
| Colitis | 196.76 | 25.82 | 125 | 11119 | 102198 | 110475857 |
| Balance disorder | 186.66 | 25.82 | 127 | 11117 | 116433 | 110461622 |
| Haematochezia | 182.92 | 25.82 | 125 | 11119 | 115399 | 110462656 |
| Therapeutic product effect incomplete | 175.66 | 25.82 | 160 | 11084 | 223645 | 110354410 |
| Rectal haemorrhage | 162.61 | 25.82 | 118 | 11126 | 119715 | 110458340 |
| Creatinine renal clearance increased | 157.35 | 25.82 | 42 | 11202 | 3583 | 110574472 |
| Dyspepsia | 156.64 | 25.82 | 140 | 11104 | 190825 | 110387230 |
| Renal function test abnormal | 155.38 | 25.82 | 51 | 11193 | 8895 | 110569160 |
| Erythema | 133.46 | 25.82 | 156 | 11088 | 291291 | 110286764 |
| Pain | 120.58 | 25.82 | 285 | 10959 | 954670 | 109623385 |
| Weight decreased | 109.18 | 25.82 | 181 | 11063 | 467876 | 110110179 |
| Multiple drug therapy | 108.89 | 25.82 | 38 | 11206 | 7976 | 110570079 |
| Mobility decreased | 108.48 | 25.82 | 127 | 11117 | 237295 | 110340760 |
| Abdominal pain | 95.86 | 25.82 | 180 | 11064 | 512809 | 110065246 |
| Infusion related reaction | 86.92 | 25.82 | 146 | 11098 | 381016 | 110197039 |
| Anaemia | 78.40 | 25.82 | 172 | 11072 | 546914 | 110031141 |
| Pyrexia | 69.09 | 25.82 | 224 | 11020 | 898041 | 109680014 |
| Malaise | 67.24 | 25.82 | 184 | 11060 | 671635 | 109906420 |
| Hypotension | 53.86 | 25.82 | 145 | 11099 | 523704 | 110054351 |
| Toxicity to various agents | 51.40 | 25.82 | 135 | 11109 | 480420 | 110097635 |
| Fatigue | 44.82 | 25.82 | 35 | 11209 | 1215923 | 109362132 |
| Fall | 41.37 | 25.82 | 145 | 11099 | 603337 | 109974718 |
| Injection related reaction | 39.94 | 25.82 | 12 | 11232 | 1566 | 110576489 |
| Nausea | 33.99 | 25.82 | 228 | 11016 | 1235462 | 109342593 |
| Off label use | 31.72 | 25.82 | 260 | 10984 | 1499925 | 109078130 |
| Condition aggravated | 31.24 | 25.82 | 18 | 11226 | 734818 | 109843237 |
| Overdose | 28.39 | 25.82 | 69 | 11175 | 233725 | 110344330 |
| Weight increased | 27.01 | 25.82 | 5 | 11239 | 419639 | 110158416 |
| Arthralgia | 26.73 | 25.82 | 24 | 11220 | 779608 | 109798447 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AB05 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| MeSH PA | D002400 | Cathartics |
| MeSH PA | D005765 | Gastrointestinal Agents |
| CHEBI has role | CHEBI:50503 | laxative |
| CHEBI has role | CHEBI:75325 | cathartic |
Related Drugs by ATC class:
A06AB Contact laxatives 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Multiple Species | External wounds | Indication |
| Multiple Species | Removal of necrotic tissue, exudate and organic debris | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Trypzyme Aerosol | Farnam Companies Inc. | 3 |
| Granulex V | Mylan Institutional Inc. | 3 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEMBL2109005 | ChEMBL_ID |
| DB11113 | DRUGBANK_ID |
| 34239008 | SNOMEDCT_US |
| 774188002 | SNOMEDCT_US |
| 4008463 | VANDF |
| 4024405 | VANDF |
| C0007343 | UMLSCUI |
| D002368 | MESH_DESCRIPTOR_UI |
| D06462 | KEGG_DRUG |
| 4367 | MMSL |
| 5344 | MMSL |
| d01014 | MMSL |
| 001177 | NDDF |
| 002478 | NDDF |
| 008584 | NDDF |
| D5340Y2I9G | UNII |
| 2129 | RXNORM |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Well at Walgreens Castor Oil | HUMAN OTC DRUG LABEL | 1 | 0363-0078 | OIL | 1 g | ORAL | OTC Monograph Drug | 16 sections |
| Well at Walgreens Castor Oil | HUMAN OTC DRUG LABEL | 1 | 0363-0078 | OIL | 1 g | ORAL | OTC Monograph Drug | 16 sections |
| Humco Castor Oil (Regular) | HUMAN OTC DRUG LABEL | 1 | 0395-0513 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Humco Castor Oil | HUMAN OTC DRUG LABEL | 1 | 0395-0515 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Humco Castor Oil | HUMAN OTC DRUG LABEL | 1 | 0395-9113 | LIQUID | 1 mg | ORAL | OTC monograph not final | 13 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 0869-0078 | LIQUID | 1 g | ORAL | OTC Monograph Drug | 15 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 11344-078 | LIQUID | 1 g | ORAL | OTC Monograph Drug | 15 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 11344-870 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 15 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 11344-870 | LIQUID | 1 mL | ORAL | OTC Monograph Drug | 15 sections |
| Rite Aid Castor Oil | HUMAN OTC DRUG LABEL | 1 | 11822-0645 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Balsamic Liniment | HUMAN OTC DRUG LABEL | 2 | 16638-042 | LINIMENT | 35.60 g | TOPICAL | OTC monograph not final | 9 sections |
| Signature Care | HUMAN OTC DRUG LABEL | 1 | 21130-078 | OIL | 1 g | ORAL | OTC Monograph Drug | 16 sections |
| De La Cruz Castor Oil | HUMAN OTC DRUG LABEL | 1 | 24286-1526 | OIL | 1 g | ORAL | OTC Monograph Drug | 15 sections |
| GNP Castor Oil | HUMAN OTC DRUG LABEL | 1 | 24385-515 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Top Care Castor Oil | HUMAN OTC DRUG LABEL | 1 | 36800-270 | OIL | 1 mg | ORAL | OTC Monograph Drug | 8 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 36800-952 | LIQUID | 1 g | ORAL | OTC Monograph Drug | 15 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 41163-078 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 16 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 41163-078 | LIQUID | 1 mL | ORAL | OTC Monograph Drug | 16 sections |
| DDM Castor Oil | HUMAN OTC DRUG LABEL | 1 | 53943-515 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 55910-979 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 15 sections |
| Quality Choice Castor Oil | HUMAN OTC DRUG LABEL | 1 | 63868-322 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Premiere Value Castor Oil | HUMAN OTC DRUG LABEL | 1 | 68016-515 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Harris Teeter Castor Oil | HUMAN OTC DRUG LABEL | 1 | 69256-515 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 13 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 69452-487 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 13 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 69842-978 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 15 sections |
| Leader Castor Oil | HUMAN OTC DRUG LABEL | 1 | 70000-0024 | OIL | 1 g | ORAL | OTC Monograph Drug | 16 sections |
| Foster and Thrive Castor Oil | HUMAN OTC DRUG LABEL | 1 | 70677-1085 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 12 sections |
| Castor Oil | HUMAN OTC DRUG LABEL | 1 | 70677-1317 | LIQUID | 1 mg | ORAL | OTC Monograph Drug | 13 sections |
| CLBiO Cleansing Pack | HUMAN OTC DRUG LABEL | 6 | 70874-0001 | SOAP | 0.30 g | TOPICAL | unapproved drug other | 7 sections |
| CLBiO Cleansing Pack | HUMAN OTC DRUG LABEL | 6 | 70874-0002 | SOAP | 0.30 g | TOPICAL | unapproved drug other | 7 sections |