dupilumab šŸ¶ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
human origin 5224 1190264-60-8

Description:

MoleculeDescription

Synonyms:

  • dupilumab
  • REGN668
  • SAR231893
  • dupixent
Dupilumab is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4RĪ± subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab inhibits IL-4 signaling via the Type I receptor and both IL-4 and IL-13 signaling through the Type II receptor. Blocking IL-4RĪ± with dupilumab inhibits IL-4 and IL-13 cytokine-induced responses, including the release of proinflammatory cytokines, chemokines and IgE.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
21.40 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 3, 2017 EMA sanofi-aventis groupe
Jan. 19, 2018 PMDA Sanofi KK
March 28, 2017 FDA REGENERON PHARMACEUTICALS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 33608.55 20.91 17291 493286 156408 89961462
Pruritus 31815.03 20.91 25323 485254 516202 89601668
Product use in unapproved indication 26134.38 20.91 18632 491945 317604 89800266
Dry skin 23622.30 20.91 10978 499599 77095 90040775
Eczema 22425.31 20.91 9110 501467 43760 90074110
Exposure via skin contact 14074.29 20.91 4288 506289 6417 90111453
Inappropriate schedule of product administration 11874.64 20.91 8434 502143 141499 89976371
Dry eye 11862.05 20.91 6012 504565 51919 90065951
Product dose omission in error 11567.47 20.91 4350 506227 16153 90101717
Skin exfoliation 11308.91 20.91 6137 504440 61776 90056094
Therapeutic response shortened 10804.81 20.91 4265 506312 18614 90099256
Product dose omission issue 10502.58 20.91 10397 500180 281290 89836580
Accidental exposure to product 10456.07 20.91 4995 505582 37371 90080499
Injection site swelling 10024.02 20.91 5430 505147 54409 90063461
Rash 9676.42 20.91 16541 494036 779559 89338311
Eye pruritus 9220.13 20.91 4079 506498 24948 90092922
Incorrect dose administered 8932.25 20.91 5551 505026 73379 90044491
Injection site erythema 8034.65 20.91 5647 504930 92855 90025015
Skin fissures 6982.20 20.91 3040 507537 17769 90100101
Skin burning sensation 6730.19 20.91 2911 507666 16700 90101170
Sleep disorder due to a general medical condition 5356.42 20.91 3264 507313 41474 90076396
Ocular hyperaemia 5230.66 20.91 2913 507664 30885 90086985
Rash erythematous 5010.65 20.91 3605 506972 61499 90056371
Eye irritation 4853.82 20.91 2779 507798 31199 90086671
Injection site pruritus 4576.03 20.91 3168 507409 50666 90067204
Therapeutic response decreased 4525.84 20.91 3871 506706 85858 90032012
Impaired quality of life 4330.31 20.91 2263 508314 20881 90096989
Rebound atopic dermatitis 4278.79 20.91 1118 509459 486 90117384
Injection site rash 4170.22 20.91 2239 508338 21934 90095936
Rebound eczema 4142.97 20.91 1029 509548 179 90117691
Injection site bruising 4050.72 20.91 2908 507669 49399 90068471
Injection site urticaria 3951.27 20.91 1961 508616 16050 90101820
Erythema 3911.45 20.91 5591 504986 223655 89894215
Condition aggravated 3711.87 20.91 9435 501142 586110 89531760
Product preparation error 3528.95 20.91 1526 509051 8735 90109135
Conjunctivitis 3411.46 20.91 2032 508545 24674 90093196
Rash macular 3176.30 20.91 2032 508545 28248 90089622
Skin haemorrhage 3150.43 20.91 1785 508792 19595 90098275
Skin swelling 3134.24 20.91 1237 509340 5377 90112493
Rebound effect 3078.63 20.91 1350 509227 8034 90109836
Illness 2695.44 20.91 2790 507787 79179 90038691
Skin weeping 2551.29 20.91 849 509728 1951 90115919
Vision blurred 2391.45 20.91 3026 507551 107267 90010603
COVID-19 2344.79 20.91 3744 506833 165099 89952771
Infusion related reaction 2210.24 20.91 26 510551 416754 89701116
Oral herpes 2084.84 20.91 1635 508942 31889 90085981
Drug intolerance 2079.08 20.91 108 510469 447483 89670387
Intentional dose omission 1945.94 20.91 1226 509351 16557 90101313
Arthralgia 1871.27 20.91 8993 501584 769529 89348341
Scratch 1845.75 20.91 965 509612 8901 90108969
Synovitis 1804.12 20.91 9 510568 329743 89788127
Pemphigus 1798.76 20.91 7 510570 326857 89791013
Product prescribing issue 1756.31 20.91 871 509706 7108 90110762
Cough 1736.46 20.91 5286 505291 363676 89754194
Skin irritation 1721.13 20.91 1029 509548 12574 90105296
Acute kidney injury 1684.75 20.91 23 510554 320364 89797506
Confusional state 1664.03 20.91 137 510440 386068 89731802
Hepatic enzyme increased 1656.14 20.91 93 510484 360643 89757227
Dermatitis atopic 1651.01 20.91 1232 509345 22240 90095630
Contraindicated product administered 1641.62 20.91 33 510544 320106 89797764
Hand deformity 1616.32 20.91 9 510568 296353 89821517
Glossodynia 1589.94 20.91 49 510528 321730 89796140
Vomiting 1589.82 20.91 1271 509306 787022 89330848
Injection site reaction 1587.75 20.91 2260 508317 89820 90028050
Lacrimation increased 1582.29 20.91 1273 509304 25789 90092081
Toxicity to various agents 1579.09 20.91 7 510570 287839 89830031
Death 1573.54 20.91 328 510249 456223 89661647
Systemic lupus erythematosus 1506.15 20.91 148 510429 361748 89756122
Diarrhoea 1498.22 20.91 1860 508717 937330 89180540
Nausea 1493.07 20.91 2482 508095 1107834 89010036
Anaemia 1417.71 20.91 164 510413 352638 89765232
Pericarditis 1404.74 20.91 23 510554 270128 89847742
Arthropathy 1376.84 20.91 210 510367 366032 89751838
Rash pruritic 1364.79 20.91 1982 508595 80232 90037638
Drug effect less than expected 1362.73 20.91 674 509903 5464 90112406
Eye discharge 1321.23 20.91 728 509849 7530 90110340
Nasal congestion 1311.21 20.91 1960 508617 81454 90036416
Treatment failure 1302.81 20.91 110 510467 303818 89814052
Drug interaction 1266.29 20.91 72 510505 276381 89841489
Rheumatoid arthritis 1264.57 20.91 253 510324 362361 89755509
General physical health deterioration 1256.86 20.91 239 510338 354876 89762994
Eye swelling 1229.97 20.91 1142 509435 28244 90089626
Injection site mass 1217.41 20.91 1004 509573 21086 90096784
Hypertension 1215 20.91 529 510048 457003 89660867
Neutropenia 1169.78 20.91 19 510558 224885 89892985
Hypotension 1168.61 20.91 211 510366 325186 89792684
Wound 1163.41 20.91 163 510414 302817 89815053
Drug ineffective 1148.01 20.91 12353 498224 1371945 88745925
Helicobacter infection 1129.54 20.91 32 510545 226818 89891052
Eyelids pruritus 1129.48 20.91 423 510154 1541 90116329
Eye pain 1100.92 20.91 1301 509276 42867 90075003
Extra dose administered 1089.65 20.91 665 509912 8453 90109417
Thrombocytopenia 1088.20 20.91 17 510560 208708 89909162
Impaired healing 1088.05 20.91 56 510521 234143 89883727
Product storage error 1078.10 20.91 902 509675 19339 90098531
Injection site irritation 1075.88 20.91 571 510006 5444 90112426
Lower respiratory tract infection 1043.79 20.91 102 510475 250557 89867313
Joint swelling 1025.99 20.91 801 509776 502499 89615371
Asthenia 1025.70 20.91 900 509677 532851 89585019
Type 2 diabetes mellitus 1003.36 20.91 31 510546 203213 89914657
Folliculitis 998.74 20.91 34 510543 204319 89913551
Eyelid skin dryness 981.00 20.91 283 510294 301 90117569
Psoriatic arthropathy 977.32 20.91 83 510494 228252 89889618
Intentional product use issue 953.04 20.91 70 510507 216822 89901048
Muscle injury 944.83 20.91 9 510568 176645 89941225
Oedema peripheral 928.53 20.91 166 510411 257749 89860121
Lack of injection site rotation 919.28 20.91 300 510277 631 90117239
Irritable bowel syndrome 917.10 20.91 65 510512 207383 89910487
Liver injury 910.78 20.91 9 510568 170558 89947312
Abdominal pain 904.02 20.91 556 510021 395165 89722705
Eyelid margin crusting 897.95 20.91 348 510229 1424 90116446
Abdominal discomfort 880.95 20.91 835 509742 476493 89641377
Stomatitis 867.56 20.91 237 510340 274461 89843409
Eye disorder 854.33 20.91 907 509670 26483 90091387
Erythema of eyelid 851.29 20.91 401 510176 2882 90114988
C-reactive protein increased 849.99 20.91 41 510536 181348 89936522
Injury 846.55 20.91 71 510506 197278 89920592
Swelling of eyelid 842.89 20.91 470 510107 4984 90112886
Skin discomfort 815.53 20.91 332 510245 1589 90116281
Blood cholesterol increased 814.70 20.91 105 510472 207907 89909963
Periorbital swelling 809.13 20.91 438 510139 4360 90113510
Decreased appetite 804.62 20.91 570 510007 375970 89741900
Oedema 804.34 20.91 93 510484 200202 89917668
Skin discolouration 799.52 20.91 1112 509465 43203 90074667
Completed suicide 798.05 20.91 3 510574 145055 89972815
Mobility decreased 794.23 20.91 215 510362 250519 89867351
Sleep disorder 788.51 20.91 2682 507895 195348 89922522
Ill-defined disorder 786.26 20.91 69 510508 184822 89933048
Overdose 782.18 20.91 23 510554 157686 89960184
Pain of skin 767.48 20.91 673 509904 15409 90102461
Fear of injection 755.57 20.91 515 510062 8000 90109870
Osteoarthritis 749.41 20.91 106 510471 195624 89922246
Musculoskeletal pain 744.53 20.91 58 510519 171193 89946677
Fatigue 744.23 20.91 3664 506913 1150359 88967511
Fibromyalgia 743.99 20.91 132 510445 206137 89911733
Disease progression 735.08 20.91 35 510542 156580 89961290
Stress 727.85 20.91 1492 509085 79903 90037967
Dermatitis 725.47 20.91 754 509823 21466 90096404
Injection site discomfort 716.91 20.91 436 510141 5504 90112366
Haemoglobin decreased 703.66 20.91 55 510522 161901 89955969
White blood cell count decreased 692.88 20.91 69 510508 167040 89950830
Hyponatraemia 687.10 20.91 13 510564 133525 89984345
Joint range of motion decreased 686.87 20.91 16 510561 135627 89982243
Rhinorrhoea 683.91 20.91 1527 509050 86789 90031081
C-reactive protein abnormal 669.98 20.91 9 510568 127420 89990450
Injection site warmth 659.27 20.91 642 509935 16873 90100997
Injection site dryness 655.16 20.91 217 510360 488 90117382
Musculoskeletal stiffness 654.46 20.91 433 510144 296099 89821771
Pancytopenia 653.45 20.91 4 510573 120259 89997611
Injection site vesicles 649.23 20.91 362 510215 3838 90114032
Anosmia 648.37 20.91 497 510080 9351 90108519
Hypokalaemia 643.41 20.91 21 510556 131095 89986775
Injection site discolouration 637.07 20.91 481 510096 8839 90109031
Blepharitis 618.17 20.91 344 510233 3632 90114238
Alanine aminotransferase increased 599.02 20.91 14 510563 118324 89999546
Platelet count decreased 590.85 20.91 48 510529 136921 89980949
Swollen joint count increased 584.00 20.91 8 510569 111198 90006672
Pneumonia 577.51 20.91 1765 508812 636294 89481576
Eyelid rash 576.21 20.91 174 510403 246 90117624
Malignant neoplasm progression 573.47 20.91 5 510572 106865 90011005
Fall 573.16 20.91 1157 509420 480653 89637217
Gastrointestinal disorder 570.16 20.91 372 510205 256315 89861555
Bursitis 568.28 20.91 46 510531 131608 89986262
Constipation 565.85 20.91 450 510127 279945 89837925
Injection site haemorrhage 553.77 20.91 739 509838 27579 90090291
Delirium 545.88 20.91 8 510569 104351 90013519
Hordeolum 542.83 20.91 340 510237 4538 90113332
Therapy non-responder 542.48 20.91 66 510511 136638 89981232
Prescribed overdose 531.65 20.91 3 510574 97622 90020248
Hypercholesterolaemia 530.93 20.91 7 510570 100885 90016985
Sepsis 529.68 20.91 176 510401 179638 89938232
Oropharyngeal pain 529.45 20.91 1639 508938 113548 90004322
Pyrexia 527.83 20.91 1929 508648 658556 89459314
Leukopenia 525.59 20.91 8 510569 100702 90017168
Sensitive skin 518.77 20.91 290 510287 3091 90114779
Tachycardia 518.74 20.91 125 510452 157548 89960322
Renal failure 518.02 20.91 64 510513 130943 89986927
Liver disorder 516.19 20.91 45 510532 121224 89996646
Aspartate aminotransferase increased 506.79 20.91 16 510561 102921 90014949
Intentional overdose 505.37 20.91 4 510573 93830 90024040
Wound infection 501.78 20.91 23 510554 106379 90011491
Pulmonary fibrosis 501.29 20.91 25 510552 107478 90010392
Therapeutic product effect decreased 499.34 20.91 496 510081 277075 89840795
Blood creatinine increased 498.28 20.91 16 510561 101370 90016500
Pulmonary embolism 497.97 20.91 72 510505 130748 89987122
Obesity 493.69 20.91 24 510553 105483 90012387
Swelling 489.15 20.91 1017 509560 418041 89699829
Malaise 486.30 20.91 1684 508893 584302 89533568
Adverse event 485.34 20.91 49 510528 117369 90000501
Dehydration 472.38 20.91 253 510324 194194 89923676
Pleural effusion 467.44 20.91 45 510532 111946 90005924
Cardiac arrest 466.16 20.91 32 510545 104903 90012967
Eyelid irritation 465.18 20.91 185 510392 823 90117047
Drug-induced liver injury 463.76 20.91 9 510568 90309 90027561
Muscular weakness 460.93 20.91 298 510279 206368 89911502
Sleep disorder due to general medical condition, insomnia type 460.38 20.91 84 510493 128610 89989260
Eye inflammation 460.25 20.91 370 510207 7481 90110389
Surgery 459.44 20.91 871 509706 44016 90073854
Intercepted product storage error 455.76 20.91 151 510426 340 90117530
Breast cancer stage III 452.86 20.91 4 510573 84443 90033427
Injection site exfoliation 450.05 20.91 153 510424 385 90117485
Drug abuse 446.01 20.91 3 510574 82344 90035526
Medication error 440.57 20.91 7 510570 84645 90033225
Respiratory failure 439.67 20.91 70 510507 118348 89999522
Influenza 439.39 20.91 1750 508827 137514 89980356
Eczema eyelids 434.54 20.91 135 510442 223 90117647
Weight decreased 431.58 20.91 936 509641 378974 89738896
Scab 428.52 20.91 389 510188 9332 90108538
Gastrointestinal haemorrhage 420.74 20.91 21 510556 90227 90027643
Live birth 414.01 20.91 6 510571 79101 90038769
Neurodermatitis 413.57 20.91 241 510336 2797 90115073
Peripheral venous disease 413.28 20.91 13 510564 83908 90033962
Therapeutic response unexpected 409.55 20.91 559 510018 21321 90096549
Product use issue 405.54 20.91 3212 507365 326707 89791163
Night sweats 404.56 20.91 112 510465 128654 89989216
Dyspepsia 399.66 20.91 318 510259 197842 89920028
Red blood cell sedimentation rate increased 399.00 20.91 15 510562 82580 90035290
Blood pressure increased 397.11 20.91 317 510260 196900 89920970
Grip strength decreased 394.95 20.91 34 510543 92542 90025328
Bradycardia 392.52 20.91 19 510558 83828 90034042
Septic shock 387.88 20.91 21 510556 84139 90033731
Renal impairment 387.61 20.91 64 510513 105357 90012513
Electrocardiogram QT prolonged 385.86 20.91 4 510573 72452 90045418
Liver function test increased 385.47 20.91 23 510554 84832 90033038
Acne 381.01 20.91 622 509955 27885 90089985
Deep vein thrombosis 379.25 20.91 38 510539 91582 90026288
Hand dermatitis 379.09 20.91 138 510439 454 90117416
Product quality issue 374.50 20.91 17 510560 79308 90038562
Suicide attempt 373.76 20.91 11 510566 75388 90042482
Eye infection 373.63 20.91 431 510146 13823 90104047
Epilepsy 371.26 20.91 23 510554 82183 90035687
Ocular discomfort 370.86 20.91 299 510278 6071 90111799
Hepatitis 367.50 20.91 6 510571 70733 90047137
Depressed level of consciousness 363.07 20.91 10 510567 72774 90045096
Interstitial lung disease 361.94 20.91 16 510561 76389 90041481
Seizure 359.94 20.91 206 510371 152423 89965447
Cardiac failure 355.84 20.91 89 510488 109407 90008463
Eyelid exfoliation 355.07 20.91 112 510465 200 90117670
Rectal haemorrhage 354.05 20.91 30 510547 82714 90035156
Multiple organ dysfunction syndrome 350.08 20.91 7 510570 68329 90049541
Neutrophil count decreased 348.97 20.91 12 510565 71520 90046350
Periorbital irritation 346.30 20.91 85 510492 10 90117860
Hyperkalaemia 344.05 20.91 4 510573 64960 90052910
Coma 338.26 20.91 17 510560 72615 90045255
Unintentional use for unapproved indication 335.67 20.91 109 510468 224 90117646
Gait inability 333.62 20.91 206 510371 146250 89971620
Chest pain 333.52 20.91 824 509753 318821 89799049
Urticaria 333.26 20.91 2949 507628 309785 89808085
Amnesia 330.51 20.91 100 510477 108405 90009465
Cardio-respiratory arrest 329.51 20.91 5 510572 63135 90054735
Somnolence 328.47 20.91 417 510160 208667 89909203
Lung disorder 322.21 20.91 225 510352 149658 89968212
Injection site inflammation 320.68 20.91 239 510338 4302 90113568
Drug hypersensitivity 317 20.91 1438 509139 462171 89655699
Device use issue 313.92 20.91 218 510359 3495 90114375
Sneezing 313.61 20.91 586 509991 29283 90088587
Product administered at inappropriate site 310.09 20.91 226 510351 3925 90113945
Mucosal inflammation 303.16 20.91 4 510573 57621 90060249
Cognitive disorder 302.99 20.91 23 510554 69384 90048486
Hypoglycaemia 302.51 20.91 24 510553 69824 90048046
Depression 295.84 20.91 798 509779 299803 89818067
Atrial fibrillation 290.61 20.91 198 510379 133413 89984457
Perioral dermatitis 285.10 20.91 112 510465 479 90117391
Skin disorder 284.39 20.91 635 509942 36071 90081799
Hepatic cirrhosis 281.76 20.91 19 510558 63234 90054636
Dyspnoea 281.49 20.91 6716 503861 874239 89243631
Visual impairment 281.41 20.91 1481 509096 130884 89986986
Secretion discharge 279.36 20.91 394 510183 15502 90102368
Hospitalisation 274.20 20.91 1436 509141 126664 89991206
Blood pressure systolic increased 273.81 20.91 13 510564 58332 90059538
Eye allergy 273.03 20.91 138 510439 1177 90116693
SARS-CoV-2 test positive 272.58 20.91 325 510252 10803 90107067
Suicidal ideation 271.13 20.91 45 510532 73810 90044060
Sciatica 268.86 20.91 117 510460 101265 90016605
Foot deformity 268.43 20.91 17 510560 59634 90058236
Tremor 264.75 20.91 283 510294 152890 89964980
Neuropathy peripheral 264.75 20.91 229 510348 136741 89981129
Rhabdomyolysis 263.56 20.91 5 510572 51251 90066619
Pregnancy 258.72 20.91 25 510552 62022 90055848
Wrong technique in device usage process 258.18 20.91 234 510343 5601 90112269
Liver function test abnormal 253.54 20.91 7 510570 50838 90067032
Off label use 251.26 20.91 4538 506039 1097714 89020156
Sedation 250.58 20.91 4 510573 48167 90069703
Myalgia 250.54 20.91 1768 508809 173357 89944513
Hypoxia 248.90 20.91 52 510525 72347 90045523
Encephalopathy 245.31 20.91 3 510574 46441 90071429
Hepatotoxicity 241.96 20.91 3 510574 45839 90072031
Dizziness 241.53 20.91 2140 508437 587144 89530726
Symptom recurrence 241.51 20.91 191 510386 3768 90114102
Cardiac failure congestive 240.19 20.91 128 510449 98566 90019304
Initial insomnia 238.14 20.91 278 510299 9032 90108838
Lupus vulgaris 237.60 20.91 3 510574 45056 90072814
Hypoaesthesia 235.88 20.91 940 509637 313270 89804600
Haematochezia 231.63 20.91 57 510520 70856 90047014
Underdose 229.95 20.91 20 510557 53997 90063873
Osteoporosis 229.39 20.91 129 510448 96402 90021468
Syncope 229.38 20.91 245 510332 132418 89985452
Blood bilirubin increased 228.75 20.91 3 510574 43467 90074403
Hepatic function abnormal 228.51 20.91 7 510570 46281 90071589
Lower limb fracture 227.19 20.91 97 510480 84916 90032954
Memory impairment 226.17 20.91 483 510094 196761 89921109
Ascites 226.10 20.91 10 510567 47730 90070140
Agitation 222.97 20.91 52 510525 67046 90050824
Lactic acidosis 222.33 20.91 16 510561 50447 90067423
Autoimmune disorder 219.19 20.91 79 510498 76665 90041205
Multiple sclerosis relapse 215.66 20.91 22 510555 52283 90065587
Hallucination 215.48 20.91 53 510524 65906 90051964
Gastrooesophageal reflux disease 215.31 20.91 379 510198 165958 89951912
Device expulsion 214.37 20.91 3 510574 40883 90076987
Dry mouth 213.30 20.91 448 510129 183611 89934259
Device defective 210.12 20.91 167 510410 3319 90114551
Drug reaction with eosinophilia and systemic symptoms 209.17 20.91 7 510570 42751 90075119
Blood pressure fluctuation 208.63 20.91 25 510552 52388 90065482
Eosinophil count increased 207.67 20.91 309 510268 12772 90105098
Infection 207.12 20.91 1194 509383 360900 89756970
Off label use of device 206.26 20.91 81 510496 346 90117524
Osteonecrosis of jaw 204.45 20.91 3 510574 39100 90078770
Abdominal pain upper 203.95 20.91 1072 509505 331602 89786268
Haematocrit decreased 200.66 20.91 8 510569 41824 90076046
Blood alkaline phosphatase increased 198.81 20.91 20 510557 48059 90069811
Hyperglycaemia 198.77 20.91 26 510551 50944 90066926
Plasma cell myeloma 198.62 20.91 7 510570 40821 90077049
Exostosis 198.12 20.91 31 510546 53103 90064767
Serotonin syndrome 197.70 20.91 3 510574 37884 90079986
Lupus-like syndrome 197.67 20.91 22 510555 48824 90069046
General physical condition abnormal 197.32 20.91 190 510387 4921 90112949
Lip dry 197.26 20.91 167 510410 100788 90017082
Retinitis 196.74 20.91 4 510573 38454 90079416
Balance disorder 195.38 20.91 156 510421 96924 90020946
Middle insomnia 191.50 20.91 341 510236 16410 90101460
Frequent bowel movements 191.43 20.91 43 510534 56892 90060978
Burning sensation 190.94 20.91 786 509791 62666 90055204
Chronic kidney disease 190.08 20.91 28 510549 50163 90067707
Hepatic failure 189.21 20.91 8 510569 39720 90078150
Road traffic accident 189.16 20.91 196 510381 107430 90010440
Myocardial infarction 188.50 20.91 191 510386 105781 90012089
Colitis ulcerative 188.17 20.91 53 510524 60213 90057657
Onychomadesis 187.96 20.91 20 510557 45978 90071892
Loss of consciousness 187.48 20.91 313 510264 139925 89977945
Pneumonia aspiration 186.22 20.91 11 510566 40929 90076941
Transaminases increased 185.89 20.91 5 510572 37187 90080683
Fluid retention 185.66 20.91 135 510442 87956 90029914
Hypomagnesaemia 184.93 20.91 3 510574 35585 90082285
Cholestasis 184.80 20.91 4 510573 36295 90081575
Hip arthroplasty 183.74 20.91 100 510477 76108 90041762
Upper-airway cough syndrome 183.27 20.91 316 510261 14819 90103051
Gamma-glutamyltransferase increased 182.92 20.91 7 510570 37945 90079925
Pancreatitis 182.90 20.91 82 510495 69744 90048126
Respiratory tract congestion 182.61 20.91 447 510130 26963 90090907
Nail disorder 182.48 20.91 53 510524 59014 90058856
Respiration abnormal 181.10 20.91 224 510353 7739 90110131
Anxiety 180.06 20.91 1016 509561 308756 89809114
Laboratory test abnormal 179.52 20.91 15 510562 41839 90076031
Red blood cell count decreased 177.53 20.91 25 510552 46326 90071544
Unresponsive to stimuli 177.25 20.91 9 510568 38112 90079758
Blood creatine phosphokinase increased 176.24 20.91 3 510574 34020 90083850
Foreign body sensation in eyes 175.57 20.91 147 510430 3153 90114717
Hypothyroidism 174.89 20.91 42 510535 53085 90064785
Premature delivery 174.55 20.91 11 510566 38751 90079119
Acute respiratory failure 174.51 20.91 19 510558 42899 90074971
Orthostatic hypotension 173.99 20.91 17 510560 41810 90076060
Disability 173.67 20.91 15 510562 40730 90077140
Hypercalcaemia 173.43 20.91 4 510573 34236 90083634
Foetal exposure during pregnancy 172.29 20.91 20 510557 42955 90074915
Pain 171.34 20.91 4291 506286 992050 89125820
Peripheral swelling 171.33 20.91 1495 509082 411611 89706259
Nasal obstruction 170.14 20.91 131 510446 2481 90115389
Generalised tonic-clonic seizure 169.73 20.91 6 510571 34897 90082973
Alopecia 169.15 20.91 1878 508699 493193 89624677
Productive cough 168.38 20.91 869 509708 76194 90041676
Dysarthria 168.10 20.91 49 510528 54433 90063437
Toxic epidermal necrolysis 167.95 20.91 3 510574 32525 90085345
Finger deformity 166.02 20.91 4 510573 32893 90084977
Toothache 165.98 20.91 379 510198 21851 90096019
Gait disturbance 165.49 20.91 829 509748 259667 89858203
Oesophageal food impaction 164.26 20.91 62 510515 232 90117638
Palpitations 163.31 20.91 327 510250 136401 89981469
Drug tolerance decreased 161.79 20.91 4 510573 32126 90085744
Joint dislocation 161.78 20.91 28 510549 44554 90073316
Heart rate decreased 161.67 20.91 50 510527 53455 90064415
Blood pressure decreased 161.48 20.91 112 510465 74783 90043087
Blood glucose increased 161.20 20.91 179 510398 95067 90022803
Pharyngitis streptococcal 160.83 20.91 271 510306 12471 90105399
Rosacea 160.35 20.91 181 510396 5666 90112204
Adverse drug reaction 159.22 20.91 257 510320 116444 90001426
Hepatic cytolysis 159.02 20.91 3 510574 30913 90086957
Altered state of consciousness 158.50 20.91 4 510573 31528 90086342
Full blood count abnormal 157.29 20.91 13 510564 36584 90081286
Nasal polyps 157.18 20.91 246 510331 10634 90107236
Acute myocardial infarction 156.81 20.91 10 510567 34880 90082990
Jaundice 156.71 20.91 6 510571 32511 90085359
Femur fracture 156.55 20.91 34 510543 46048 90071822
Coeliac disease 155.49 20.91 31 510546 44579 90073291
Injection site eczema 155.30 20.91 46 510531 58 90117812
Pharyngeal swelling 155.15 20.91 233 510344 9711 90108159
Lymphocyte count decreased 154.73 20.91 11 510566 35039 90082831
Sinus operation 154.52 20.91 131 510446 2860 90115010
Respiratory arrest 154.46 20.91 8 510569 33303 90084567
Contusion 153.62 20.91 810 509767 250406 89867464
Injection site nodule 153.61 20.91 156 510421 4317 90113553
Skin mass 153.13 20.91 199 510378 7231 90110639
Colitis 152.92 20.91 103 510474 69839 90048031
Periorbital inflammation 151.97 20.91 53 510524 148 90117722
Eosinophilic oesophagitis 151.90 20.91 81 510496 780 90117090
Cholelithiasis 151.73 20.91 53 510524 52453 90065417
Pulmonary hypertension 151.50 20.91 28 510549 42495 90075375
Hypophagia 151.09 20.91 14 510563 35923 90081947
Device dislocation 151.07 20.91 6 510571 31476 90086394
Coronary artery disease 150.04 20.91 10 510567 33613 90084257
Disorientation 148.94 20.91 33 510544 44081 90073789
Haematuria 148.53 20.91 13 510564 34924 90082946
Drug effective for unapproved indication 147.72 20.91 202 510375 7716 90110154
Haematemesis 147.69 20.91 11 510566 33715 90084155
Skin erosion 146.45 20.91 134 510443 3248 90114622
Intentional self-injury 146.40 20.91 4 510573 29330 90088540
Sinus tachycardia 145.72 20.91 3 510574 28510 90089360
Urinary tract infection 144.66 20.91 1067 509510 304565 89813305
Acute respiratory distress syndrome 142.84 20.91 4 510573 28682 90089188
Eosinophilic granulomatosis with polyangiitis 141.47 20.91 116 510461 2414 90115456
Mood disorder due to a general medical condition 141.39 20.91 45 510532 84 90117786
Asthenopia 141.14 20.91 123 510454 2791 90115079
Skin texture abnormal 139.60 20.91 68 510509 531 90117339
Rash maculo-papular 139.46 20.91 30 510547 40903 90076967
Drug withdrawal syndrome 139.46 20.91 5 510572 28718 90089152
Walking aid user 138.72 20.91 18 510559 35488 90082382
Food allergy 138.46 20.91 385 510192 25093 90092777
Facial discomfort 138.32 20.91 57 510520 283 90117587
Pulmonary oedema 137.64 20.91 90 510487 61990 90055880
Hypervolaemia 137.09 20.91 13 510564 32744 90085126
Urinary retention 136.32 20.91 24 510553 37720 90080150
Blood urea increased 135.85 20.91 9 510568 30404 90087466
Aphasia 134.87 20.91 37 510540 42775 90075095
White blood cell count increased 134.11 20.91 109 510468 67132 90050738
Miliaria 132.79 20.91 90 510487 1384 90116486
Injection site induration 132.61 20.91 223 510354 10245 90107625
Arrhythmia 132.58 20.91 37 510540 42295 90075575
Palmar-plantar erythrodysaesthesia syndrome 132.28 20.91 6 510571 28017 90089853
Hyposmia 132.25 20.91 77 510500 892 90116978
Drainage 131.70 20.91 52 510525 226 90117644
Blood lactate dehydrogenase increased 131.46 20.91 3 510574 25929 90091941
Cytomegalovirus infection 131.40 20.91 4 510573 26598 90091272
Metastases to liver 130.24 20.91 8 510569 28799 90089071
Shock 130.08 20.91 8 510569 28770 90089100
Drug dependence 130.05 20.91 9 510568 29318 90088552
Inflammation 129.69 20.91 541 510036 178051 89939819
Psychotic disorder 129.10 20.91 13 510564 31217 90086653
Angina pectoris 128.82 20.91 31 510546 39129 90078741
Skin warm 128.41 20.91 186 510391 7501 90110369
Rash papular 128.28 20.91 325 510252 20030 90097840
Dyskinesia 128.15 20.91 25 510552 36509 90081361
Body temperature increased 127.71 20.91 46 510531 44664 90073206
Oxygen saturation decreased 127.54 20.91 258 510319 107225 90010645
Paranasal sinus discomfort 127.47 20.91 166 510411 6044 90111826
Dandruff 127.47 20.91 54 510523 291 90117579
Angioedema 127.12 20.91 107 510470 64769 90053101
Injection site discharge 126.93 20.91 87 510490 1364 90116506
Pancreatitis acute 126.15 20.91 16 510561 32099 90085771
Ejection fraction decreased 125.99 20.91 5 510572 26248 90091622
Metastases to bone 125.38 20.91 4 510573 25501 90092369
Eyelid pain 125.16 20.91 69 510508 714 90117156
Drug resistance 125.03 20.91 13 510564 30436 90087434
Ventricular tachycardia 124.71 20.91 3 510574 24705 90093165
Full blood count decreased 123.67 20.91 12 510565 29677 90088193
Muscle spasms 122.72 20.91 872 509705 251011 89866859
Stevens-Johnson syndrome 122.03 20.91 12 510565 29364 90088506
Abdominal distension 121.46 20.91 356 510221 130245 89987625
Exposure during pregnancy 121.26 20.91 815 509762 237595 89880275
Basal cell carcinoma 121.09 20.91 21 510556 33368 90084502
Respiratory distress 120.20 20.91 35 510542 38911 90078959
Blood pressure diastolic decreased 119.64 20.91 8 510569 26818 90091052
Clostridium difficile colitis 119.00 20.91 8 510569 26698 90091172
Pneumonitis 118.64 20.91 50 510527 44120 90073750
Red blood cell sedimentation rate abnormal 118.26 20.91 4 510573 24200 90093670
Nasopharyngitis 117.25 20.91 3063 507514 404041 89713829
Needle issue 116.96 20.91 249 510328 13685 90104185
Cardiogenic shock 116.28 20.91 5 510572 24463 90093407
Hepatic steatosis 116.25 20.91 32 510545 36913 90080957
Blood calcium decreased 116.25 20.91 16 510561 30166 90087704
Oropharyngeal discomfort 116.09 20.91 178 510399 7557 90110313
Sunburn 115.96 20.91 116 510461 3151 90114719
Atelectasis 115.96 20.91 5 510572 24404 90093466
Hallucination, visual 115.80 20.91 3 510574 23089 90094781
Cystitis 115.54 20.91 123 510454 66595 90051275
Myositis 114.43 20.91 5 510572 24123 90093747
Cerebral haemorrhage 114.20 20.91 27 510550 34495 90083375
Dysgeusia 114.10 20.91 78 510499 52482 90065388
Pulmonary arterial hypertension 113.38 20.91 9 510568 26178 90091692
Sensitivity to weather change 113.06 20.91 190 510387 8724 90109146
Onychomycosis 112.79 20.91 35 510542 37341 90080529
Diabetic ketoacidosis 112.73 20.91 6 510571 24401 90093469
Adrenal insufficiency 112.59 20.91 17 510560 29904 90087966
Discomfort 112.32 20.91 2170 508407 272165 89845705
Disease recurrence 112.31 20.91 36 510541 37617 90080253
Upper gastrointestinal haemorrhage 111.55 20.91 4 510573 22972 90094898
Device related infection 111.26 20.91 9 510568 25777 90092093
Cerebral infarction 110.13 20.91 11 510566 26585 90091285
Proteinuria 109.89 20.91 5 510572 23286 90094584
Back injury 109.75 20.91 63 510514 46559 90071311
Hyperlipidaemia 107.86 20.91 5 510572 22911 90094959
Pustule 107.22 20.91 105 510472 2778 90115092
Injury associated with device 107.07 20.91 129 510448 4335 90113535
Accidental overdose 106.53 20.91 16 510561 28257 90089613
Taste disorder 105.98 20.91 114 510463 61432 90056438
Conjunctivitis allergic 105.16 20.91 75 510502 1257 90116613
Neck pain 104.27 20.91 313 510264 113650 90004220
Circulatory collapse 103.91 20.91 10 510567 24894 90092976
Ulcer haemorrhage 103.66 20.91 13 510564 26308 90091562
Haematoma 103.61 20.91 45 510532 39003 90078867
Cellulitis 102.70 20.91 226 510351 91111 90026759
Immunodeficiency 102.38 20.91 58 510519 43176 90074694
Premature baby 102.21 20.91 11 510566 25066 90092804
Skin depigmentation 101.82 20.91 70 510507 1103 90116767
Cerebrovascular accident 101.42 20.91 356 510221 123177 89994693
Hemiparesis 101.17 20.91 27 510550 31792 90086078
Osteonecrosis 100.85 20.91 14 510563 26227 90091643
Electrolyte imbalance 100.50 20.91 9 510568 23736 90094134
Lip erythema 99.61 20.91 48 510529 365 90117505
Pallor 99.56 20.91 34 510543 34131 90083739
Gastric disorder 99.43 20.91 32 510545 33352 90084518
Tachypnoea 99.17 20.91 5 510572 21304 90096566
Abdominal pain lower 99.04 20.91 24 510553 30153 90087717
Therapeutic product effect incomplete 98.99 20.91 662 509915 193234 89924636
Chapped lips 98.30 20.91 100 510477 2773 90115097
Infection parasitic 98.11 20.91 52 510525 494 90117376
Foetal death 96.01 20.91 5 510572 20718 90097152
Lymphopenia 95.96 20.91 9 510568 22872 90094998
Injection site scar 95.17 20.91 69 510508 1188 90116682
Intentional product misuse 94.72 20.91 844 509733 88760 90029110
Respiratory syncytial virus infection 94.66 20.91 193 510384 10287 90107583
Right ventricular failure 94.45 20.91 3 510574 19202 90098668
Aggression 94.06 20.91 18 510559 26650 90091220
Eosinophilic pneumonia 93.93 20.91 96 510481 2677 90115193
Heart rate increased 92.93 20.91 325 510252 112577 90005293
Bacteraemia 92.92 20.91 9 510568 22291 90095579
Urosepsis 92.76 20.91 7 510570 21225 90096645
Intestinal obstruction 92.04 20.91 47 510530 37084 90080786
Adverse reaction 91.15 20.91 27 510550 29685 90088185
Dermatitis contact 90.86 20.91 222 510355 13373 90104497
Body temperature decreased 90.84 20.91 13 510564 23803 90094067
Myoclonus 90.82 20.91 4 510573 19164 90098706
Pericardial effusion 90.74 20.91 47 510530 36786 90081084
Coagulopathy 90.52 20.91 12 510565 23277 90094593
Treatment noncompliance 89.97 20.91 95 510482 51632 90066238
Pneumocystis jirovecii pneumonia 89.35 20.91 9 510568 21607 90096263
Therapy partial responder 89.01 20.91 10 510567 22033 90095837
Clostridium difficile infection 88.18 20.91 47 510530 36198 90081672
Coordination abnormal 87.99 20.91 9 510568 21347 90096523
Iron deficiency anaemia 87.77 20.91 14 510563 23648 90094222
Peritonitis 87.52 20.91 6 510571 19699 90098171
Radiculopathy 87.22 20.91 4 510573 18501 90099369
Urinary incontinence 86.67 20.91 52 510525 37514 90080356
Vaginal haemorrhage 86.26 20.91 34 510543 31237 90086633
Drug eruption 86.01 20.91 46 510531 35361 90082509
Scar 85.99 20.91 235 510342 15160 90102710
Spinal operation 85.35 20.91 182 510395 10014 90107856
Cardiomyopathy 84.60 20.91 8 510569 20198 90097672
Poor venous access 83.74 20.91 7 510570 19520 90098350
Menstruation delayed 83.30 20.91 80 510497 2065 90115805
Maternal exposure during pregnancy 82.85 20.91 1478 509099 358585 89759285
Pyelonephritis 82.81 20.91 11 510566 21305 90096565
Exfoliative rash 82.78 20.91 96 510481 3096 90114774
Ischaemic stroke 82.48 20.91 13 510564 22153 90095717
Haemorrhoids 82.40 20.91 24 510553 26678 90091192
Osteomyelitis 82.38 20.91 27 510550 27819 90090051
Device operational issue 82.35 20.91 58 510519 952 90116918
Lack of administration site rotation 81.72 20.91 25 510552 38 90117832
Affect lability 81.71 20.91 5 510572 18058 90099812
Viral infection 81.59 20.91 454 510123 40960 90076910
Platelet count increased 80.47 20.91 11 510566 20848 90097022
Vitreous floaters 80.35 20.91 149 510428 7400 90110470
Gastroenteritis 80.26 20.91 32 510545 29197 90088673
Drug ineffective for unapproved indication 80.09 20.91 646 509931 65998 90051872
Polyneuropathy 80.08 20.91 8 510569 19333 90098537
Ileus 79.92 20.91 3 510574 16543 90101327
Joint effusion 79.44 20.91 9 510568 19701 90098169
Aphonia 78.99 20.91 198 510379 12121 90105749
Transient ischaemic attack 78.86 20.91 76 510501 43100 90074770
Ataxia 78.68 20.91 6 510571 18036 90099834
Leukocytosis 78.66 20.91 38 510539 30952 90086918
Cytopenia 78.42 20.91 5 510572 17444 90100426
Swelling face 78.28 20.91 751 509826 80601 90037269
Drug tolerance 78.01 20.91 6 510571 17910 90099960
Seronegative arthritis 76.93 20.91 7 510570 18227 90099643
Skin hypertrophy 76.45 20.91 98 510479 3512 90114358
Blood potassium decreased 76.12 20.91 94 510483 47633 90070237
Pigmentation disorder 75.71 20.91 127 510450 5822 90112048
Skin necrosis 75.70 20.91 5 510572 16936 90100934
Small intestinal obstruction 75.60 20.91 14 510563 21220 90096650
Dyshidrotic eczema 74.66 20.91 49 510528 712 90117158
Abnormal behaviour 74.26 20.91 18 510559 22610 90095260
Diabetes mellitus inadequate control 74.14 20.91 9 510568 18675 90099195
Vaginal discharge 73.37 20.91 11 510566 19453 90098417
Obstructive airways disorder 73.23 20.91 27 510550 25842 90092028
Hypoalbuminaemia 73.13 20.91 4 510573 15893 90101977
Exposure via eye contact 72.88 20.91 19 510558 8 90117862
Spinal compression fracture 72.47 20.91 3 510574 15175 90102695
Visual acuity reduced 72.31 20.91 21 510556 23389 90094481
Bone disorder 70.94 20.91 21 510556 23099 90094771
Transfusion 70.44 20.91 8 510569 17480 90100390
Keratitis 69.95 20.91 99 510478 3907 90113963
Motor dysfunction 69.94 20.91 12 510565 19218 90098652
Bone density decreased 69.70 20.91 8 510569 17337 90100533
Temperature regulation disorder 69.21 20.91 3 510574 14576 90103294
Breast cancer metastatic 69.02 20.91 4 510573 15128 90102742
Haemoptysis 68.98 20.91 52 510525 33268 90084602
Complication associated with device 68.87 20.91 13 510564 19436 90098434
Oral candidiasis 68.81 20.91 59 510518 35396 90082474
Knee arthroplasty 68.75 20.91 239 510338 82943 90034927
Lethargy 68.72 20.91 159 510418 62980 90054890
Sensory loss 68.63 20.91 10 510567 18065 90099805
Superficial injury of eye 68.28 20.91 37 510540 369 90117501
Increased viscosity of upper respiratory secretion 68.27 20.91 32 510545 227 90117643
Musculoskeletal disorder 68.22 20.91 19 510558 21750 90096120
Schizophrenia 67.85 20.91 4 510573 14910 90102960
Chest discomfort 67.73 20.91 1126 509451 137239 89980631
Gastric ulcer 67.65 20.91 35 510542 27413 90090457
Glomerular filtration rate decreased 67.57 20.91 8 510569 16924 90100946
Brain oedema 67.47 20.91 9 510568 17376 90100494
Dystonia 66.99 20.91 8 510569 16811 90101059
Diabetes mellitus 66.95 20.91 168 510409 64707 90053163
Osteopenia 66.84 20.91 23 510554 22979 90094891
Skin wound 66.71 20.91 68 510509 1890 90115980
Malnutrition 66.58 20.91 12 510565 18546 90099324
Neutrophil count increased 66.48 20.91 14 510563 19376 90098494
Skin atrophy 66.36 20.91 115 510462 5414 90112456
Hyperhidrosis 66.28 20.91 472 510105 135833 89982037
Cardiomegaly 66.27 20.91 13 510564 18912 90098958
Nasal polypectomy 66.05 20.91 21 510556 39 90117831
Injection site hypoaesthesia 65.69 20.91 43 510534 622 90117248
Emotional distress 65.27 20.91 66 510511 36596 90081274
Myocardial ischaemia 65.06 20.91 3 510574 13811 90104059
Pharyngeal oedema 64.83 20.91 3 510574 13768 90104102
Cardiac murmur 64.77 20.91 12 510565 18182 90099688
Back pain 64.64 20.91 1329 509248 315846 89802024
Muscle rigidity 64.61 20.91 4 510573 14305 90103565
Device dispensing error 64.33 20.91 28 510549 163 90117707
Knee operation 64.15 20.91 129 510448 6807 90111063
Product complaint 63.36 20.91 3 510574 13497 90104373
Spinal osteoarthritis 63.29 20.91 15 510562 19133 90098737
Face oedema 63.26 20.91 26 510551 23292 90094578
Allergy to animal 62.93 20.91 61 510516 1593 90116277
Mydriasis 62.71 20.91 6 510571 15006 90102864
Blood test abnormal 62.54 20.91 20 510557 20932 90096938
Anaphylactic shock 62.11 20.91 52 510525 31565 90086305
Aplastic anaemia 62.11 20.91 3 510574 13266 90104604
Keratoconus 61.99 20.91 18 510559 20 90117850
Laryngitis 61.77 20.91 120 510457 50633 90067237
Blepharospasm 61.66 20.91 138 510439 55307 90062563
Injection site indentation 61.57 20.91 32 510545 291 90117579
Fear 61.28 20.91 10 510567 16612 90101258
Breast cancer 61.28 20.91 132 510445 53629 90064241
Hypertensive crisis 60.65 20.91 13 510564 17771 90100099
Periorbital pain 59.17 20.91 31 510546 287 90117583
Escherichia urinary tract infection 59.11 20.91 5 510572 13810 90104060
Hemiplegia 58.96 20.91 10 510567 16150 90101720
Poisoning 58.76 20.91 8 510569 15209 90102661
Thrombosis 58.18 20.91 214 510363 73037 90044833
Blood potassium increased 58.16 20.91 22 510555 20727 90097143
Flank pain 58.00 20.91 18 510559 19204 90098666
Foreign body in eye 57.75 20.91 26 510551 166 90117704
Lip exfoliation 57.69 20.91 42 510535 728 90117142
Supraventricular tachycardia 57.67 20.91 11 510566 16325 90101545
Hydronephrosis 57.43 20.91 3 510574 12399 90105471
Panniculitis 57.28 20.91 7 510570 14451 90103419
Blood pressure diastolic increased 57.11 20.91 4 510573 12902 90104968
Cholecystitis 57.01 20.91 13 510564 17027 90100843
Gangrene 56.95 20.91 4 510573 12872 90104998
Intestinal perforation 56.80 20.91 6 510571 13875 90103995
Ocular surface disease 56.80 20.91 20 510557 58 90117812
Eczema asteatotic 56.46 20.91 31 510546 318 90117552
Respiratory disorder 56.46 20.91 182 510395 64634 90053236
Nephropathy toxic 55.95 20.91 4 510573 12684 90105186
Dysuria 55.40 20.91 85 510492 39316 90078554
Withdrawal syndrome 55.10 20.91 29 510548 22495 90095375
Anal incontinence 55.07 20.91 12 510565 16218 90101652
Myopathy 54.92 20.91 6 510571 13512 90104358
Cutaneous T-cell lymphoma 54.72 20.91 56 510521 1564 90116306
Abortion induced 54.66 20.91 3 510574 11885 90105985
Menstruation irregular 54.27 20.91 132 510445 7928 90109942
Colitis ischaemic 54.14 20.91 4 510573 12342 90105528
Cyanosis 53.91 20.91 21 510556 19434 90098436
Cheilitis 53.51 20.91 99 510478 4908 90112962
Chronic sinusitis 53.45 20.91 34 510543 23768 90094102
Central nervous system lesion 53.36 20.91 3 510574 11643 90106227
Rales 53.10 20.91 12 510565 15815 90102055
Nasal dryness 53.03 20.91 105 510472 5478 90112392
Renal disorder 52.92 20.91 82 510495 37777 90080093
Idiopathic urticaria 52.47 20.91 30 510547 335 90117535
Injection site hypersensitivity 52.33 20.91 70 510507 2617 90115253
Hypotonia 52.18 20.91 3 510574 11423 90106447
Skin tightness 52.12 20.91 92 510485 4396 90113474
Vascular device infection 52.05 20.91 4 510573 11948 90105922
Eczema weeping 52.04 20.91 16 510561 25 90117845
Injection site paraesthesia 52.03 20.91 38 510539 662 90117208
Cardiac failure acute 51.92 20.91 4 510573 11925 90105945
General symptom 51.52 20.91 10 510567 14658 90103212
Migraine 51.21 20.91 759 509818 189633 89928237
Arthropod bite 51.15 20.91 136 510441 8631 90109239
Product used for unknown indication 51.12 20.91 39 510538 728 90117142
Chills 50.95 20.91 486 510091 131495 89986375
Tooth disorder 50.89 20.91 60 510517 31030 90086840
Toxic skin eruption 50.88 20.91 13 510564 15761 90102109
Polyarthritis 50.53 20.91 20 510557 18330 90099540
Alcohol intolerance 50.52 20.91 21 510556 107 90117763
Hand-foot-and-mouth disease 50.49 20.91 33 510544 476 90117394
Deformity 50.48 20.91 5 510572 12165 90105705
Infusion site pain 50.41 20.91 24 510553 19714 90098156
Restlessness 50.28 20.91 77 510500 35643 90082227
Anaphylactic reaction 50.26 20.91 288 510289 87236 90030634
Skin hyperpigmentation 50.25 20.91 116 510461 6735 90111135
Diverticulum 50.18 20.91 5 510572 12108 90105762
Respiratory rate increased 50.08 20.91 14 510563 15987 90101883
Fistula 50.05 20.91 5 510572 12084 90105786
Skin wrinkling 49.57 20.91 50 510527 1372 90116498
Macular degeneration 49.56 20.91 86 510491 37884 90079986
Splenomegaly 49.42 20.91 7 510570 12917 90104953
Body height decreased 49.32 20.91 5 510572 11944 90105926
Ear discomfort 48.55 20.91 147 510430 10053 90107817
Quality of life decreased 48.07 20.91 162 510415 11727 90106143
Spinal stenosis 47.97 20.91 19 510558 17405 90100465
Metastases to lymph nodes 47.97 20.91 5 510572 11684 90106186
Dysphagia 47.90 20.91 894 509683 111384 90006486
Parosmia 47.85 20.91 116 510461 6953 90110917
Urine output decreased 47.79 20.91 7 510570 12596 90105274
Incorrect dose administered by device 47.55 20.91 102 510475 5635 90112235
Blister 47.44 20.91 1084 509493 253914 89863956
Renal cyst 47.28 20.91 8 510569 12942 90104928
Speech disorder 47.07 20.91 118 510459 45467 90072403
Mania 46.81 20.91 11 510566 14113 90103757
Seborrhoeic dermatitis 46.75 20.91 53 510524 1667 90116203
Pain in jaw 46.66 20.91 128 510449 47857 90070013
Tardive dyskinesia 46.64 20.91 4 510573 10926 90106944
Sudden death 46.53 20.91 4 510573 10905 90106965
Hepatitis acute 46.42 20.91 4 510573 10883 90106987
Ecchymosis 46.37 20.91 7 510570 12316 90105554
Dermatitis bullous 46.23 20.91 3 510574 10313 90107557
Menstrual disorder 46.21 20.91 105 510472 6033 90111837
Aspergillus infection 46.08 20.91 4 510573 10819 90107051
Paraesthesia 46.05 20.91 1066 509511 249260 89868610
Injection site injury 46.05 20.91 41 510536 958 90116912
Molluscum contagiosum 45.92 20.91 27 510550 319 90117551
Renal injury 45.84 20.91 3 510574 10240 90107630
Product administration error 45.42 20.91 49 510528 26374 90091496
Ocular rosacea 45.38 20.91 12 510565 6 90117864
Arthritis 45.34 20.91 666 509911 166649 89951221
Skin lesion 45.32 20.91 363 510214 37002 90080868
Hypogammaglobulinaemia 45.30 20.91 4 510573 10670 90107200
Photophobia 45.16 20.91 238 510339 21031 90096839
Encephalitis 45.08 20.91 5 510572 11129 90106741
Aspiration 45.07 20.91 16 510561 15677 90102193
Fungal skin infection 44.80 20.91 95 510482 5206 90112664
Skin discharge 44.75 20.91 18 510559 83 90117787
Photosensitivity reaction 44.73 20.91 209 510368 17598 90100272
Pre-eclampsia 44.64 20.91 5 510572 11043 90106827
Enterococcal infection 44.49 20.91 3 510574 9988 90107882
Multiple sclerosis 44.22 20.91 55 510522 27785 90090085
Pleuritic pain 44.18 20.91 4 510573 10457 90107413
Bronchopulmonary aspergillosis 43.99 20.91 6 510571 11392 90106478
Cushingoid 43.83 20.91 4 510573 10391 90107479
Decreased activity 43.73 20.91 123 510454 8069 90109801
Therapeutic response delayed 43.44 20.91 37 510540 813 90117057
Acute coronary syndrome 43.42 20.91 5 510572 10808 90107062
Blood sodium decreased 43.39 20.91 55 510522 27558 90090312
Nasal pruritus 43.23 20.91 35 510542 715 90117155
Lung infiltration 43.17 20.91 16 510561 15266 90102604
Blood triglycerides increased 43.14 20.91 12 510565 13749 90104121
Large intestine perforation 43.01 20.91 3 510574 9709 90108161
Product administration interrupted 42.87 20.91 9 510568 12483 90105387
Troponin increased 42.74 20.91 11 510566 13270 90104600
Escherichia infection 42.67 20.91 18 510559 15877 90101993
Blood loss anaemia 42.49 20.91 4 510573 10136 90107734
Gestational diabetes 42.23 20.91 5 510572 10577 90107293
Skin hypopigmentation 42.10 20.91 42 510535 1137 90116733
Sinus disorder 41.97 20.91 335 510242 34112 90083758
Anhedonia 41.87 20.91 7 510570 11424 90106446
Faecaloma 41.45 20.91 5 510572 10426 90107444
Hyperthyroidism 41.33 20.91 26 510551 18284 90099586
Hyperthermia 40.95 20.91 5 510572 10330 90107540
Vitamin D deficiency 40.93 20.91 24 510553 17532 90100338
Nephropathy 40.47 20.91 3 510574 9232 90108638
Fracture 40.15 20.91 39 510538 22037 90095833
Skin ulcer 39.96 20.91 445 510132 49630 90068240
Intervertebral disc degeneration 39.72 20.91 24 510553 17250 90100620
Oligomenorrhoea 39.69 20.91 39 510538 1036 90116834
Arteriosclerosis coronary artery 39.69 20.91 4 510573 9599 90108271
Eyelid thickening 39.40 20.91 16 510561 76 90117794
Vasculitis 39.10 20.91 42 510535 22651 90095219
Eye operation 38.78 20.91 61 510516 2648 90115222
Blood calcium increased 38.78 20.91 10 510567 12048 90105822
Arterial occlusive disease 38.75 20.91 11 510566 12435 90105435
Eczema nummular 38.74 20.91 23 510554 277 90117593
Pelvic pain 38.72 20.91 19 510558 15338 90102532
Lower gastrointestinal haemorrhage 38.65 20.91 3 510574 8889 90108981
Epstein-Barr virus infection 38.64 20.91 6 510571 10338 90107532
Infusion site extravasation 38.56 20.91 6 510571 10322 90107548
Atrial flutter 38.50 20.91 7 510570 10751 90107119
Spondylitis 38.15 20.91 16 510561 14162 90103708
Choking 37.73 20.91 151 510426 11882 90105988
Pulmonary mass 37.71 20.91 65 510512 28707 90089163
Enterobiasis 37.70 20.91 17 510560 109 90117761
Nightmare 37.67 20.91 40 510537 21685 90096185
Spinal fracture 37.65 20.91 41 510536 21975 90095895
Tinnitus 37.56 20.91 121 510456 42981 90074889
Infusion site erythema 37.48 20.91 15 510562 13655 90104215
Pre-existing condition improved 37.43 20.91 4 510573 9165 90108705
Breath sounds abnormal 37.36 20.91 20 510557 15366 90102504
Faeces discoloured 37.25 20.91 39 510538 21281 90096589
Presyncope 37.16 20.91 77 510500 31728 90086142
Mouth ulceration 37.12 20.91 109 510468 39865 90078005
Monocyte count increased 37.05 20.91 4 510573 9093 90108777
Breast cancer female 36.87 20.91 174 510403 14712 90103158
Eye symptom 36.69 20.91 18 510559 143 90117727
Hiatus hernia 36.34 20.91 54 510523 25307 90092563
Sinus headache 36.31 20.91 99 510478 6377 90111493
Therapy interrupted 36.21 20.91 152 510425 49956 90067914
Large intestine polyp 36.09 20.91 5 510572 9381 90108489
Staphylococcal sepsis 36.07 20.91 5 510572 9378 90108492
Nervous system disorder 36.07 20.91 41 510536 21552 90096318
Device breakage 35.98 20.91 17 510560 14027 90103843
Hepatomegaly 35.92 20.91 15 510562 13311 90104559
Dark circles under eyes 35.71 20.91 29 510548 595 90117275
Ventricular extrasystoles 35.58 20.91 15 510562 13235 90104635
SARS-CoV-1 test positive 35.48 20.91 10 510567 9 90117861
Disturbance in attention 35.24 20.91 141 510436 46968 90070902
Genital haemorrhage 35.00 20.91 4 510573 8698 90109172
Myocarditis 34.93 20.91 17 510560 13789 90104081
Abnormal sensation in eye 34.85 20.91 49 510528 1922 90115948
Ulcer 34.83 20.91 84 510493 32798 90085072
Chromaturia 34.77 20.91 34 510543 19153 90098717
Mental impairment 34.73 20.91 26 510551 16694 90101176
Procedural pain 34.72 20.91 86 510491 33274 90084596
Pathogen resistance 34.55 20.91 3 510574 8112 90109758
Tinea infection 34.35 20.91 40 510537 1296 90116574
End stage renal disease 34.33 20.91 4 510573 8567 90109303
Enteritis 34.28 20.91 8 510569 10313 90107557
Polymenorrhoea 34.07 20.91 41 510536 1376 90116494
Affective disorder 34.03 20.91 109 510468 7684 90110186
Decubitus ulcer 34.00 20.91 12 510565 11801 90106069
Fungal infection 33.99 20.91 379 510198 42282 90075588
Apathy 33.92 20.91 10 510567 11030 90106840
Lip pruritus 33.77 20.91 40 510537 1320 90116550
Eczema herpeticum 33.71 20.91 19 510558 206 90117664
Cardiovascular disorder 33.55 20.91 17 510560 13475 90104395
Periorbital disorder 33.54 20.91 12 510565 37 90117833
Bronchiectasis 33.53 20.91 46 510531 22284 90095586
Blood magnesium decreased 33.12 20.91 24 510553 15669 90102201
Nasal operation 33.04 20.91 21 510556 288 90117582
Breast cancer stage I 32.89 20.91 7 510570 9617 90108253
Colitis microscopic 32.70 20.91 11 510566 11148 90106722
Eye ulcer 32.58 20.91 24 510553 424 90117446
Swollen tear duct 32.55 20.91 11 510566 27 90117843
Facial paralysis 32.47 20.91 24 510553 15510 90102360
Weight fluctuation 32.44 20.91 38 510539 19711 90098159
Deafness 32.20 20.91 48 510529 22466 90095404
Synovial cyst 32.05 20.91 13 510564 11739 90106131
Product dispensing issue 31.55 20.91 24 510553 446 90117424
Mood altered 31.18 20.91 184 510393 16960 90100910
Staphylococcal bacteraemia 31.16 20.91 3 510574 7466 90110404
Gluten sensitivity 31.12 20.91 30 510547 778 90117092
Arthritis bacterial 31.03 20.91 3 510574 7442 90110428
Major depression 31.00 20.91 9 510568 10026 90107844
Drug dose omission by device 30.97 20.91 127 510450 10104 90107766
Product availability issue 30.82 20.91 3 510574 7401 90110469
Blood lactic acid increased 30.80 20.91 6 510571 8772 90109098
Bundle branch block left 30.79 20.91 4 510573 7881 90109989
Serum ferritin increased 30.70 20.91 3 510574 7378 90110492
Psychomotor hyperactivity 30.61 20.91 17 510560 12796 90105074
Incorrect dose administered by product 30.56 20.91 19 510558 250 90117620
Congestive cardiomyopathy 30.56 20.91 3 510574 7351 90110519
Ankylosing spondylitis 30.55 20.91 18 510559 13115 90104755
Diverticulum intestinal 30.54 20.91 7 510570 9135 90108735
Abortion spontaneous 30.43 20.91 179 510398 53877 90063993
Exposure to extreme temperature 30.26 20.91 8 510569 4 90117866
Atrial septal defect 30.25 20.91 5 510572 8229 90109641
Embolism 30.23 20.91 8 510569 9473 90108397
Dry throat 30.03 20.91 106 510471 7854 90110016
Enthesopathy 29.86 20.91 8 510569 9396 90108474
Aortic arteriosclerosis 29.77 20.91 4 510573 7680 90110190
Renal function test abnormal 29.71 20.91 3 510574 7188 90110682
Seborrhoea 29.63 20.91 25 510552 542 90117328
Decreased interest 29.49 20.91 72 510505 4335 90113535
Tuberculosis 29.47 20.91 17 510560 12532 90105338
Sticky skin 29.46 20.91 10 510567 25 90117845
Swollen tongue 29.28 20.91 146 510431 45810 90072060
Paralysis 29.24 20.91 14 510563 11464 90106406
Lymphadenopathy 29.22 20.91 390 510187 45385 90072485
Protein total decreased 29.17 20.91 3 510574 7086 90110784
Pulmonary haemorrhage 29.14 20.91 5 510572 8008 90109862
Shoulder operation 28.97 20.91 56 510521 2870 90115000
Autoimmune hepatitis 28.97 20.91 11 510566 10340 90107530
Infusion site swelling 28.80 20.91 15 510562 11705 90106165
Metabolic disorder 28.67 20.91 4 510573 7466 90110404
Intercepted product dispensing error 28.17 20.91 15 510562 144 90117726
Pain in extremity 28.07 20.91 2171 508406 448358 89669512
Oesophageal candidiasis 27.82 20.91 3 510574 6826 90111044
Mass 27.77 20.91 28 510549 15549 90102321
Postoperative wound infection 27.73 20.91 21 510556 13405 90104465
Eyelid infection 27.70 20.91 20 510557 342 90117528
Eczema infected 27.65 20.91 15 510562 150 90117720
Partial seizures 27.60 20.91 4 510573 7256 90110614
Injection site dermatitis 27.50 20.91 8 510569 9 90117861
Nystagmus 27.44 20.91 4 510573 7223 90110647
Product prescribing error 27.38 20.91 275 510302 29870 90088000
Candida infection 27.37 20.91 99 510478 33958 90083912
Inappropriate schedule of product discontinuation 27.30 20.91 11 510566 51 90117819
Iron deficiency 27.26 20.91 10 510567 9602 90108268
Eye injury 27.23 20.91 14 510563 11006 90106864
Lip blister 27.18 20.91 54 510523 2824 90115046
Left ventricular failure 27.15 20.91 3 510574 6697 90111173
Haemoglobin abnormal 26.79 20.91 4 510573 7096 90110774
Allergy to plants 26.51 20.91 28 510549 812 90117058
Incontinence 26.51 20.91 22 510555 13413 90104457
Haemoglobin increased 26.49 20.91 5 510572 7476 90110394
Pelvic fracture 26.41 20.91 28 510549 15191 90102679
Cutaneous T-cell lymphoma stage IV 26.38 20.91 9 510568 23 90117847
Diverticulitis 26.31 20.91 148 510429 45039 90072831
Thrombocytosis 26.29 20.91 4 510573 6997 90110873
Herpes ophthalmic 26.20 20.91 37 510540 1457 90116413
Systemic inflammatory response syndrome 26.20 20.91 3 510574 6513 90111357
Blood creatinine decreased 26.19 20.91 3 510574 6512 90111358
Helminthic infection 26.16 20.91 11 510566 58 90117812
Intervertebral disc protrusion 26.10 20.91 73 510504 27123 90090747
Haemorrhagic stroke 26.09 20.91 3 510574 6493 90111377
Serum sickness 26.01 20.91 60 510517 3482 90114388
Polyuria 25.96 20.91 12 510565 10028 90107842
Coronary artery occlusion 25.83 20.91 8 510569 8546 90109324
Exposure to fungus 25.77 20.91 16 510561 210 90117660
Diarrhoea haemorrhagic 25.68 20.91 14 510563 10649 90107221
Sickle cell anaemia with crisis 25.58 20.91 5 510572 7292 90110578
Neurological symptom 25.51 20.91 4 510573 6843 90111027
Erythema multiforme 25.49 20.91 19 510558 12227 90105643
Inflammatory marker increased 25.44 20.91 10 510567 9204 90108666
Atrioventricular block 25.29 20.91 9 510568 8806 90109064
Blood chloride decreased 25.18 20.91 3 510574 6316 90111554
Blood thyroid stimulating hormone increased 25.17 20.91 10 510567 9145 90108725
Allergy to arthropod bite 25.13 20.91 21 510556 449 90117421
Muscle atrophy 25.11 20.91 8 510569 8393 90109477
Conjunctival papillae 25.11 20.91 6 510571 0 90117870
Nasal inflammation 25.05 20.91 25 510552 677 90117193
Sleep apnoea syndrome 25.04 20.91 93 510484 31654 90086216
Erythema nodosum 24.94 20.91 80 510497 5644 90112226
Lung neoplasm malignant 24.93 20.91 63 510514 24210 90093660
Allergy to metals 24.86 20.91 30 510547 1010 90116860
Injection site coldness 24.71 20.91 12 510565 93 90117777
Erysipelas 24.71 20.91 10 510567 9042 90108828
Rhinalgia 24.70 20.91 48 510529 2470 90115400
Blood pressure inadequately controlled 24.69 20.91 3 510574 6221 90111649
Pneumothorax 24.48 20.91 44 510533 19123 90098747
Skin odour abnormal 24.46 20.91 40 510537 1795 90116075
Hyperaesthesia teeth 24.31 20.91 45 510532 2232 90115638
Stillbirth 24.27 20.91 6 510571 7437 90110433
Discharge 24.26 20.91 39 510538 1725 90116145
Head injury 24.19 20.91 92 510485 31096 90086774
Nasal oedema 24.19 20.91 4 510573 6580 90111290
Spinal pain 24.16 20.91 32 510545 15735 90102135
Paraesthesia oral 24.16 20.91 94 510483 31565 90086305
Electrocardiogram abnormal 24.12 20.91 14 510563 10284 90107586
Hepatic cyst 24.11 20.91 4 510573 6564 90111306
Generalised oedema 24.10 20.91 44 510533 19009 90098861
Infective pulmonary exacerbation of cystic fibrosis 24.03 20.91 14 510563 10265 90107605
Protein urine present 24.03 20.91 5 510572 6979 90110891
Seasonal allergy 24.03 20.91 216 510361 22767 90095103
Antinuclear antibody positive 23.96 20.91 11 510566 9230 90108640
Blood creatine increased 23.95 20.91 5 510572 6962 90110908
Allergy to arthropod sting 23.93 20.91 17 510560 283 90117587
Nocturia 23.93 20.91 14 510563 10241 90107629
Gallbladder operation 23.81 20.91 50 510527 2721 90115149
Throat clearing 23.80 20.91 61 510516 3786 90114084
Tongue disorder 23.72 20.91 16 510561 10844 90107026
Joint injury 23.66 20.91 99 510478 32565 90085305
Device failure 23.61 20.91 5 510572 6892 90110978
Erythrodermic atopic dermatitis 23.57 20.91 8 510569 20 90117850
Abdominal operation 23.54 20.91 28 510549 928 90116942
Therapy cessation 23.46 20.91 115 510462 36246 90081624
Wrong product administered 23.45 20.91 7 510570 7658 90110212
Impetigo 23.45 20.91 36 510541 1530 90116340
Thinking abnormal 23.41 20.91 19 510558 11713 90106157
Maternal exposure timing unspecified 23.37 20.91 58 510519 22425 90095445
Odynophagia 23.35 20.91 107 510470 8936 90108934
Eye colour change 23.35 20.91 19 510558 391 90117479
Humerus fracture 23.35 20.91 13 510564 9772 90108098
Restless legs syndrome 23.33 20.91 58 510519 22412 90095458
Orthopnoea 23.30 20.91 5 510572 6830 90111040
Herpes virus infection 23.22 20.91 84 510493 6300 90111570
Injection site joint pain 23.14 20.91 7 510570 10 90117860
Gallbladder disorder 23.09 20.91 48 510529 19755 90098115
Hyperaesthesia 23.07 20.91 16 510561 10686 90107184
Epigastric discomfort 22.99 20.91 7 510570 7561 90110309
Carotid artery occlusion 22.97 20.91 4 510573 6338 90111532
Vitiligo 22.90 20.91 42 510535 2068 90115802
Essential hypertension 22.84 20.91 4 510573 6311 90111559
Genital rash 22.84 20.91 23 510554 630 90117240
Rebound nasal congestion 22.82 20.91 9 510568 39 90117831
Insurance issue 22.81 20.91 17 510560 10941 90106929
Stress fracture 22.72 20.91 10 510567 8601 90109269
Arthropod sting 22.57 20.91 32 510545 1265 90116605
Neutrophilia 22.40 20.91 3 510574 5775 90112095
Multiple fractures 22.39 20.91 13 510564 9549 90108321
Acarodermatitis 22.37 20.91 33 510544 1353 90116517
Emotional disorder 22.35 20.91 153 510424 14844 90103026
Limb operation 22.26 20.91 66 510511 4461 90113409
Milia 22.22 20.91 13 510564 152 90117718
Necrosis 22.20 20.91 5 510572 6605 90111265
Escherichia bacteraemia 22.18 20.91 3 510574 5732 90112138
Glassy eyes 22.15 20.91 11 510566 90 90117780
Pollakiuria 22.11 20.91 103 510474 32902 90084968
Hyperphagia 22.10 20.91 49 510528 2769 90115101
Wisdom teeth removal 22.02 20.91 24 510553 722 90117148
Heart rate irregular 21.94 20.91 67 510510 24201 90093669
Ovarian cyst 21.90 20.91 40 510537 17278 90100592
Blood glucose decreased 21.67 20.91 64 510513 23365 90094505
Eyelid disorder 21.61 20.91 42 510535 2161 90115709
Hepatic enzyme abnormal 21.59 20.91 8 510569 7634 90110236
Organising pneumonia 21.38 20.91 8 510569 7589 90110281
Nasal flaring 21.36 20.91 7 510570 15 90117855
Peripheral vascular disorder 21.33 20.91 5 510572 6426 90111444
Bronchospasm 21.07 20.91 54 510523 20655 90097215
Meningitis aseptic 21.06 20.91 6 510571 6767 90111103
Drug specific antibody present 21.05 20.91 3 510574 5511 90112359
Fibrosis 21.03 20.91 4 510573 5948 90111922
Pseudomonas infection 20.96 20.91 32 510545 14833 90103037
Sunscreen sensitivity 20.92 20.91 5 510572 0 90117870
Eczema infantile 20.92 20.91 5 510572 0 90117870

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pruritus 26863.95 32.57 16589 286323 172182 42146241
Injection site pain 17480.14 32.57 8404 294508 49394 42269029
Dry skin 17345.60 32.57 7912 295000 40426 42277997
Product use in unapproved indication 15199.45 32.57 11609 291303 172847 42145576
Eczema 12957.04 32.57 5814 297098 28272 42290151
Product dose omission in error 8731.34 32.57 2972 299940 5382 42313041
Inappropriate schedule of product administration 8647.13 32.57 6390 296522 89512 42228911
Rash 8238.11 32.57 9944 292968 267010 42051413
Exposure via skin contact 8109.71 32.57 2488 300424 2550 42315873
Dry eye 7584.08 32.57 3164 299748 12342 42306081
Skin exfoliation 7364.23 32.57 4235 298677 37318 42281105
Injection site swelling 7295.28 32.57 3160 299752 13813 42304610
Therapeutic response shortened 6956.89 32.57 2863 300049 10691 42307732
Product dose omission issue 6293.05 32.57 6546 296366 147819 42170604
Accidental exposure to product 5787.66 32.57 2847 300065 17546 42300877
Eye pruritus 5603.52 32.57 2336 300576 9076 42309347
Skin fissures 5500.33 32.57 2200 300712 7476 42310947
Incorrect dose administered 5434.54 32.57 3823 299089 49151 42269272
Ocular hyperaemia 4577.52 32.57 2245 300667 13718 42304705
Therapeutic response decreased 4438.87 32.57 2943 299969 34069 42284354
Sleep disorder due to a general medical condition 4326.83 32.57 2224 300688 15229 42303194
Skin burning sensation 3841.52 32.57 1582 301330 5905 42312518
Injection site erythema 3625.46 32.57 2078 300834 18117 42300306
Eye irritation 3571.31 32.57 1700 301212 9618 42308805
Erythema 3189.01 32.57 3893 299019 104900 42213523
Condition aggravated 3031.43 32.57 6084 296828 254670 42063753
Conjunctivitis 3020.30 32.57 1584 301328 11355 42307068
Rash erythematous 3018.65 32.57 2199 300713 29892 42288531
Rebound eczema 2872.21 32.57 750 302162 101 42318322
Skin haemorrhage 2820.73 32.57 1292 301620 6593 42311830
Rebound atopic dermatitis 2681.14 32.57 729 302183 235 42318188
Acute kidney injury 2475.93 32.57 26 302886 367311 41951112
Injection site pruritus 2314.04 32.57 1193 301719 8212 42310211
Arthralgia 2305.00 32.57 4725 298187 200513 42117910
Product preparation error 2276.84 32.57 958 301954 3820 42314603
Impaired quality of life 2153.42 32.57 1310 301602 12867 42305556
Injection site urticaria 2074.55 32.57 813 302099 2570 42315853
Rash macular 2012.92 32.57 1339 301573 15552 42302871
Death 1953.91 32.57 478 302434 470707 41847716
Nasal congestion 1874.65 32.57 1605 301307 27896 42290527
Rebound effect 1818.07 32.57 937 301975 6442 42311981
Drug ineffective 1776.21 32.57 8975 293937 621222 41697201
Skin swelling 1763.86 32.57 689 302223 2153 42316270
Anaemia 1727.99 32.57 60 302852 280218 42038205
Drug interaction 1716.70 32.57 38 302874 266961 42051462
Injection site rash 1716.37 32.57 830 302082 4882 42313541
Skin weeping 1637.44 32.57 559 302353 1020 42317403
Injection site bruising 1618.10 32.57 1013 301899 10512 42307911
Discomfort 1608.19 32.57 1375 301537 23844 42294579
Toxicity to various agents 1598.92 32.57 5 302907 229131 42089292
Intentional dose omission 1596.61 32.57 919 301993 8067 42310356
Scratch 1546.24 32.57 753 302159 4508 42313915
Sleep disorder 1527.31 32.57 1795 301117 46300 42272123
Skin irritation 1427.31 32.57 805 302107 6769 42311654
Lacrimation increased 1410.14 32.57 936 301976 10822 42307601
Hypotension 1375.28 32.57 125 302787 257506 42060917
Illness 1373.21 32.57 1251 301661 23679 42294744
Febrile neutropenia 1289.78 32.57 5 302907 185698 42132725
Neutropenia 1274.89 32.57 30 302882 199401 42119022
Vision blurred 1257.26 32.57 1722 301190 51977 42266446
Rhinorrhoea 1239.54 32.57 1321 301591 30473 42287950
Injection site reaction 1219.89 32.57 961 301951 14760 42303663
Thrombocytopenia 1214.80 32.57 29 302883 190250 42128173
Product prescribing issue 1158.89 32.57 676 302236 6097 42312326
Injection site mass 1109.69 32.57 716 302196 7859 42310564
Drug effect less than expected 1046.94 32.57 523 302389 3334 42315089
Sepsis 998.30 32.57 122 302790 199212 42119211
Oral herpes 986.29 32.57 634 302278 6910 42311513
Diarrhoea 963.33 32.57 1118 301794 459731 41858692
Dermatitis atopic 938.18 32.57 747 302165 11657 42306766
Pneumonia 926.01 32.57 984 301928 421165 41897258
Eye discharge 917.25 32.57 441 302471 2554 42315869
Product use issue 912.70 32.57 1813 301099 74938 42243485
Nasopharyngitis 906.49 32.57 1906 301006 82090 42236333
Disease progression 869.52 32.57 35 302877 143621 42174802
Rash pruritic 866.46 32.57 1130 301782 32473 42285950
Nausea 848.82 32.57 944 301968 395855 41922568
Confusional state 842.87 32.57 101 302811 167496 42150927
Cough 821.64 32.57 2956 299956 175147 42143276
Product storage error 819.33 32.57 660 302252 10480 42307943
Renal failure 810.26 32.57 54 302858 143672 42174751
Extra dose administered 807.46 32.57 503 302409 5166 42313257
Pancytopenia 807.35 32.57 5 302907 117738 42200685
Platelet count decreased 790.32 32.57 49 302863 138532 42179891
Haemoglobin decreased 786.08 32.57 37 302875 132434 42185989
Anosmia 779.81 32.57 476 302436 4700 42313723
Respiratory failure 776.14 32.57 31 302881 128101 42190322
Malignant neoplasm progression 751.73 32.57 3 302909 108397 42210026
Injection site vesicles 742.11 32.57 298 302614 1022 42317401
Asthenia 697.29 32.57 584 302328 280209 42038214
Blood creatinine increased 696.88 32.57 18 302894 109985 42208438
Eyelid margin crusting 696.03 32.57 233 302679 387 42318036
Overdose 695.87 32.57 10 302902 105254 42213169
Hyponatraemia 677.93 32.57 8 302904 101454 42216969
Cardiac arrest 670.43 32.57 24 302888 109296 42209127
Lack of injection site rotation 670.15 32.57 218 302694 313 42318110
General physical health deterioration 667.56 32.57 132 302780 151114 42167309
Multiple organ dysfunction syndrome 655.94 32.57 6 302906 97029 42221394
Eyelids pruritus 636.34 32.57 190 302722 160 42318263
Fear of injection 634.89 32.57 302 302610 1701 42316722
Oedema peripheral 634.66 32.57 103 302809 135973 42182450
Injection site discomfort 624.60 32.57 314 302598 2032 42316391
White blood cell count decreased 620.55 32.57 42 302870 110354 42208069
Pulmonary embolism 619.00 32.57 65 302847 119547 42198876
Completed suicide 617.85 32.57 14 302898 96451 42221972
Erythema of eyelid 606.40 32.57 268 302644 1235 42317188
Vomiting 604.73 32.57 702 302210 289021 42029402
Dehydration 604.47 32.57 134 302778 141633 42176790
Periorbital swelling 594.80 32.57 267 302645 1286 42317137
Septic shock 592.26 32.57 12 302900 91660 42226763
Renal impairment 591.24 32.57 52 302860 110176 42208247
Abdominal pain 588.55 32.57 310 302602 190161 42128262
Eyelid skin dryness 583.20 32.57 171 302741 125 42318298
Injection site irritation 577.16 32.57 267 302645 1397 42317026
Eye pain 574.21 32.57 656 302256 16374 42302049
Gastrointestinal haemorrhage 564.79 32.57 32 302880 97694 42220729
Skin discomfort 559.68 32.57 207 302705 529 42317894
Skin discolouration 543.82 32.57 706 302206 20184 42298239
Alanine aminotransferase increased 543.45 32.57 19 302893 88387 42230036
Hypertension 536.18 32.57 259 302653 166945 42151478
Fall 527.06 32.57 534 302378 233986 42084437
Eye swelling 525.00 32.57 529 302383 11391 42307032
Tachycardia 520.26 32.57 56 302856 101031 42217392
Cardiac failure 518.59 32.57 72 302840 106784 42211639
Bradycardia 516.45 32.57 21 302891 85463 42232960
Hyperkalaemia 513.97 32.57 12 302900 80446 42237977
Pleural effusion 509.97 32.57 50 302862 97116 42221307
Atrial fibrillation 500.85 32.57 183 302729 139410 42179013
Seizure 490.18 32.57 126 302786 120435 42197988
Leukopenia 485.97 32.57 9 302903 74737 42243686
Hypokalaemia 482.02 32.57 5 302907 71716 42246707
Eye disorder 479.95 32.57 498 302414 11114 42307309
Aspartate aminotransferase increased 472.81 32.57 17 302895 77146 42241277
Rhabdomyolysis 471.86 32.57 19 302893 78000 42240423
Device use issue 467.88 32.57 197 302715 786 42317637
Food allergy 467.56 32.57 254 302658 1967 42316456
Constipation 465.66 32.57 289 302623 162002 42156421
Dermatitis 465.35 32.57 495 302417 11380 42307043
Interstitial lung disease 458.61 32.57 24 302888 78438 42239985
Sneezing 444.72 32.57 366 302546 5997 42312426
Blepharitis 440.41 32.57 233 302679 1700 42316723
Decreased appetite 436.91 32.57 437 302475 192700 42125723
Swelling of eyelid 427.63 32.57 236 302676 1892 42316531
COVID-19 407.94 32.57 1769 301143 114179 42204244
Deep vein thrombosis 405.37 32.57 39 302873 76918 42241505
Cardio-respiratory arrest 399.21 32.57 3 302909 58633 42259790
Neutrophil count decreased 391.91 32.57 13 302899 63402 42255021
Acne 391.34 32.57 484 302428 13160 42305263
Hypoxia 382.17 32.57 30 302882 69756 42248667
Hypoglycaemia 381.97 32.57 9 302903 59845 42258578
Syncope 379.68 32.57 117 302795 99289 42219134
Somnolence 378.13 32.57 271 302641 140834 42177589
Cardiac failure congestive 376.85 32.57 75 302837 85527 42232896
Therapeutic response unexpected 367.84 32.57 429 302483 10952 42307471
Ascites 367.70 32.57 7 302905 56671 42261752
Drug intolerance 365.69 32.57 65 302847 80359 42238064
Weight decreased 358.61 32.57 578 302334 207370 42111053
Urticaria 357.75 32.57 1249 301663 72787 42245636
Nasal obstruction 357.75 32.57 164 302748 837 42317586
Pyrexia 355.60 32.57 1518 301394 392524 41925899
Neuropathy peripheral 352.78 32.57 141 302771 101712 42216711
Sinusitis 350.15 32.57 927 301985 46365 42272058
Eye inflammation 349.49 32.57 241 302671 2977 42315446
C-reactive protein increased 348.96 32.57 27 302885 63533 42254890
Injection site haemorrhage 347.39 32.57 423 302489 11313 42307110
Delirium 346.92 32.57 5 302907 52514 42265909
Acute myocardial infarction 342.39 32.57 17 302895 58148 42260275
Hypersensitivity 341.15 32.57 1211 301701 71159 42247264
Off label use of device 334.75 32.57 90 302822 24 42318399
Mucosal inflammation 333.82 32.57 3 302909 49371 42269052
Myocardial infarction 332.44 32.57 238 302674 123771 42194652
Visual impairment 330.32 32.57 856 302056 42257 42276166
Haematuria 327.59 32.57 21 302891 57778 42260645
Intentional product use issue 326.71 32.57 58 302854 71775 42246648
Hordeolum 325.59 32.57 179 302733 1423 42317000
Coronary artery disease 325.08 32.57 13 302899 53707 42264716
International normalised ratio increased 320.72 32.57 4 302908 48164 42270259
Coma 320.60 32.57 14 302898 53540 42264883
Depressed level of consciousness 319.33 32.57 4 302908 47966 42270457
Ocular discomfort 315.76 32.57 222 302690 2835 42315588
Agitation 312.73 32.57 43 302869 64271 42254152
Eyelid rash 311.37 32.57 87 302825 40 42318383
Hepatic function abnormal 310.29 32.57 13 302899 51554 42266869
Symptom recurrence 309.77 32.57 169 302743 1321 42317102
Tremor 306.15 32.57 153 302759 96776 42221647
Hallucination 303.22 32.57 29 302883 57478 42260945
Foetal exposure during pregnancy 302.32 32.57 7 302905 47304 42271119
Oropharyngeal pain 296.33 32.57 815 302097 41695 42276728
Pneumonia aspiration 293.60 32.57 15 302897 50063 42268360
Scab 292.66 32.57 279 302633 5599 42312824
Product administered at inappropriate site 290.20 32.57 212 302700 2886 42315537
Unintentional use for unapproved indication 288.71 32.57 81 302831 39 42318384
Eye infection 288.47 32.57 243 302669 4118 42314305
Rectal haemorrhage 287.26 32.57 16 302896 49590 42268833
Eczema eyelids 286.60 32.57 85 302827 68 42318355
Blood creatine phosphokinase increased 284.92 32.57 14 302898 48324 42270099
Secretion discharge 284.62 32.57 310 302602 7325 42311098
Loss of consciousness 282.43 32.57 152 302760 92202 42226221
Injection site discolouration 279.59 32.57 173 302739 1753 42316670
Pain of skin 278.69 32.57 315 302597 7765 42310658
Blood pressure decreased 276.64 32.57 42 302870 58290 42260133
Blood pressure increased 275.28 32.57 194 302718 101734 42216689
Hyperglycaemia 274.46 32.57 12 302900 45847 42272576
Plasma cell myeloma 273.50 32.57 16 302896 47562 42270861
Suicide attempt 272.85 32.57 13 302899 46087 42272336
Eyelid irritation 272.71 32.57 104 302808 298 42318125
Encephalopathy 272.71 32.57 4 302908 41329 42277094
Blood bilirubin increased 267.12 32.57 7 302905 42245 42276178
Influenza 264.87 32.57 1007 301905 61168 42257255
Drug reaction with eosinophilia and systemic symptoms 262.20 32.57 8 302904 42067 42276356
Fatigue 254.31 32.57 1934 300978 433707 41884716
Chronic kidney disease 251.25 32.57 23 302889 47218 42271205
Intercepted product storage error 250.01 32.57 96 302816 282 42318141
Therapy non-responder 249.45 32.57 40 302872 53319 42265104
Urinary tract infection 247.64 32.57 205 302707 99079 42219344
Oesophageal food impaction 242.69 32.57 80 302832 123 42318300
Hepatic failure 242.04 32.57 6 302906 38094 42280329
Ear infection 240.11 32.57 370 302542 12434 42305989
Respiratory tract congestion 239.12 32.57 284 302628 7394 42311029
Drug-induced liver injury 235.91 32.57 8 302904 38265 42280158
Melaena 235.70 32.57 9 302903 38737 42279686
Skin disorder 232.80 32.57 426 302486 16518 42301905
Haematochezia 231.82 32.57 64 302848 58372 42260051
Blister 230.58 32.57 565 302347 26925 42291498
Suicidal ideation 227.63 32.57 35 302877 48126 42270297
Drug resistance 223.06 32.57 4 302908 34244 42284179
Blood glucose increased 222.83 32.57 123 302789 73576 42244847
Blood urea increased 217.09 32.57 3 302909 32790 42285633
Hyposmia 216.57 32.57 86 302826 284 42318139
Treatment failure 216.27 32.57 87 302825 62537 42255886
Respiratory distress 215.49 32.57 23 302889 41797 42276626
Pharyngitis streptococcal 215.15 32.57 196 302716 3704 42314719
Jaundice 214.01 32.57 7 302905 34582 42283841
Transaminases increased 213.53 32.57 4 302908 32881 42285542
Muscular weakness 212.46 32.57 169 302743 83329 42235094
Oxygen saturation decreased 212.03 32.57 97 302815 64590 42253833
Acute respiratory failure 211.88 32.57 17 302895 38841 42279582
Initial insomnia 211.57 32.57 197 302715 3833 42314590
Medication error 211.45 32.57 5 302907 33149 42285274
Dysarthria 210.04 32.57 20 302892 39787 42278636
Cytomegalovirus infection 209.48 32.57 4 302908 32302 42286121
Urinary retention 208.12 32.57 27 302885 42187 42276236
Neurodermatitis 207.13 32.57 105 302807 693 42317730
Pulmonary oedema 206.41 32.57 61 302851 53211 42265212
Oedema 206.19 32.57 57 302855 51944 42266479
Periorbital irritation 205.89 32.57 55 302857 13 42318410
Sensitive skin 202.37 32.57 120 302792 1118 42317305
Aggression 202.22 32.57 35 302877 44128 42274295
Angioedema 200.45 32.57 31 302881 42446 42275977
Blood alkaline phosphatase increased 200.36 32.57 9 302903 33588 42284835
Haemoptysis 197.86 32.57 43 302869 46124 42272299
Gamma-glutamyltransferase increased 196.14 32.57 8 302904 32489 42285934
Cholestasis 195.45 32.57 9 302903 32870 42285553
Malaise 194.67 32.57 811 302101 211345 42107078
Acute respiratory distress syndrome 194.13 32.57 4 302908 30104 42288319
Orthostatic hypotension 193.48 32.57 5 302907 30565 42287858
Rash maculo-papular 192.28 32.57 21 302891 37482 42280941
Thrombosis 192.16 32.57 125 302787 68386 42250037
Liver function test abnormal 192.11 32.57 9 302903 32382 42286041
Pneumonitis 191.16 32.57 33 302879 41685 42276738
Cerebral haemorrhage 189.53 32.57 26 302886 38940 42279483
Colitis 188.52 32.57 49 302863 46523 42271900
Ventricular tachycardia 186.97 32.57 6 302906 30154 42288269
Arrhythmia 186.70 32.57 31 302881 40286 42278137
Diabetes mellitus 186.45 32.57 97 302815 59990 42258433
Tubulointerstitial nephritis 186.35 32.57 9 302903 31539 42286884
Injection site warmth 184.71 32.57 153 302759 2530 42315893
Nasal polyps 184.56 32.57 179 302733 3672 42314751
Psychotic disorder 184.02 32.57 5 302907 29203 42289220
Altered state of consciousness 180.74 32.57 6 302906 29253 42289170
Red blood cell count decreased 179.25 32.57 14 302898 32701 42285722
Cerebrovascular accident 177.85 32.57 259 302653 96901 42221522
Disorientation 177.65 32.57 24 302888 36365 42282058
Surgery 176.18 32.57 388 302524 17228 42301195
Unresponsive to stimuli 176.18 32.57 12 302900 31391 42287032
Eye allergy 175.55 32.57 57 302855 81 42318342
Respiratory arrest 174.98 32.57 6 302906 28418 42290005
Toxic epidermal necrolysis 174.72 32.57 3 302909 26747 42291676
Sinus disorder 174.48 32.57 249 302663 7801 42310622
Lymphocyte count decreased 174.32 32.57 5 302907 27804 42290619
Shock 173.01 32.57 8 302904 29113 42289310
Hypothyroidism 172.28 32.57 15 302897 32069 42286354
Cerebral infarction 171.73 32.57 13 302899 31156 42287267
Upper-airway cough syndrome 171.04 32.57 182 302730 4184 42314239
Liver disorder 169.74 32.57 37 302875 39607 42278816
Drug dependence 169.63 32.57 9 302903 29085 42289338
Hepatitis 167.22 32.57 6 302906 27294 42291129
Angina pectoris 167.18 32.57 19 302893 32877 42285546
Depression 167.07 32.57 337 302575 111026 42207397
Eyelid exfoliation 165.08 32.57 45 302867 15 42318408
Pancreatitis acute 164.18 32.57 22 302890 33542 42284881
Cognitive disorder 161.10 32.57 25 302887 34147 42284276
Pneumocystis jirovecii pneumonia 159.81 32.57 4 302908 25177 42293246
Blood pressure systolic increased 158.93 32.57 10 302902 27958 42290465
Blood pressure fluctuation 157.90 32.57 8 302904 26900 42291523
Paranasal sinus discomfort 157.42 32.57 101 302811 1096 42317327
Chills 156.74 32.57 267 302645 93799 42224624
Hepatic enzyme increased 155.81 32.57 65 302847 45719 42272704
Abdominal distension 155.52 32.57 168 302744 71567 42246856
Full blood count abnormal 155.03 32.57 16 302896 29860 42288563
Hepatic cytolysis 154.35 32.57 9 302903 26835 42291588
Sinus operation 152.83 32.57 88 302824 772 42317651
Hepatotoxicity 152.54 32.57 6 302906 25161 42293262
Hypophagia 152.11 32.57 10 302902 26946 42291477
Haematemesis 152.08 32.57 18 302894 30181 42288242
Bacteraemia 151.67 32.57 6 302906 25034 42293389
Generalised tonic-clonic seizure 151.20 32.57 9 302903 26370 42292053
Accidental overdose 150.08 32.57 14 302898 28316 42290107
Injection site inflammation 148.06 32.57 95 302817 1031 42317392
Superficial injury of eye 148.03 32.57 47 302865 59 42318364
Cellulitis 146.42 32.57 133 302779 61452 42256971
Haematoma 145.43 32.57 15 302897 28008 42290415
Pancreatitis 144.73 32.57 63 302849 43205 42275218
Acute myeloid leukaemia 139.50 32.57 4 302908 22252 42296171
Pulmonary fibrosis 139.19 32.57 14 302898 26667 42291756
Burning sensation 136.70 32.57 393 302519 20620 42297803
Heart rate decreased 135.84 32.57 45 302867 36487 42281936
Chest pain 135.69 32.57 521 302391 139009 42179414
Hand dermatitis 135.54 32.57 58 302854 243 42318180
Coagulopathy 135.30 32.57 5 302907 22157 42296266
Pulmonary hypertension 135.22 32.57 8 302904 23561 42294862
Intestinal obstruction 134.76 32.57 17 302895 27141 42291282
Rheumatoid arthritis 133.91 32.57 67 302845 42373 42276050
Myelodysplastic syndrome 132.71 32.57 7 302905 22738 42295685
Stevens-Johnson syndrome 132.05 32.57 6 302906 22172 42296251
Ejection fraction decreased 131.43 32.57 6 302906 22081 42296342
Musculoskeletal pain 131.31 32.57 37 302875 33303 42285120
Benign prostatic hyperplasia 131.17 32.57 4 302908 21048 42297375
Drug withdrawal syndrome 131.08 32.57 5 302907 21544 42296879
White blood cell count increased 130.91 32.57 79 302833 45008 42273415
Hyperlipidaemia 130.85 32.57 5 302907 21511 42296912
Hand-foot-and-mouth disease 129.34 32.57 56 302856 243 42318180
Clostridium difficile colitis 129.03 32.57 5 302907 21247 42297176
Anaphylactic shock 129.02 32.57 10 302902 23507 42294916
Injection site dryness 127.37 32.57 37 302875 25 42318398
Eosinophilic oesophagitis 126.91 32.57 73 302839 639 42317784
Hypervolaemia 126.40 32.57 10 302902 23115 42295308
Ischaemic stroke 126.18 32.57 8 302904 22225 42296198
Proteinuria 125.45 32.57 10 302902 22973 42295450
Laboratory test abnormal 125.41 32.57 10 302902 22968 42295455
Circulatory collapse 124.36 32.57 12 302900 23624 42294799
Diabetic ketoacidosis 124.16 32.57 9 302903 22358 42296065
Foreign body sensation in eyes 124.16 32.57 80 302832 875 42317548
Device defective 124.06 32.57 100 302812 1588 42316835
Dyskinesia 123.33 32.57 17 302895 25373 42293050
Dysphagia 123.05 32.57 912 302000 71807 42246616
Tachypnoea 122.33 32.57 8 302904 21654 42296769
Liver injury 121.67 32.57 3 302909 19145 42299278
Pallor 121.56 32.57 28 302884 28858 42289565
Epilepsy 121.44 32.57 20 302892 26151 42292272
Full blood count decreased 121.00 32.57 6 302906 20554 42297869
Stomatitis 120.46 32.57 108 302804 50221 42268202
Hallucination, visual 118.01 32.57 8 302904 21012 42297411
Nasal polypectomy 117.89 32.57 32 302880 10 42318413
Wrong technique in device usage process 117.08 32.57 120 302792 2637 42315786
Eosinophil count increased 116.73 32.57 245 302667 10518 42307905
Lymphopenia 115.99 32.57 10 302902 21553 42296870
Device related infection 115.98 32.57 7 302905 20272 42298151
Neutrophil count increased 115.85 32.57 6 302906 19798 42298625
Miliaria 115.39 32.57 67 302845 598 42317825
Disease recurrence 114.92 32.57 34 302878 29644 42288779
Lower respiratory tract infection 114.41 32.57 76 302836 41130 42277293
Product quality issue 112.88 32.57 3 302909 17879 42300544
Sinus tachycardia 112.69 32.57 9 302903 20644 42297779
Leukocytosis 111.50 32.57 36 302876 29672 42288751
Polyneuropathy 111.26 32.57 5 302907 18656 42299767
Toothache 110.99 32.57 196 302716 7387 42311036
Respiration abnormal 110.48 32.57 140 302772 3902 42314521
Clostridium difficile infection 110.47 32.57 15 302897 22644 42295779
Cholelithiasis 110.23 32.57 17 302895 23329 42295094
Drug effective for unapproved indication 109.68 32.57 181 302731 6452 42311971
Palmar-plantar erythrodysaesthesia syndrome 109.48 32.57 10 302902 20572 42297851
Restlessness 108.80 32.57 36 302876 29213 42289210
Dysgeusia 107.83 32.57 54 302858 34135 42284288
Atelectasis 106.87 32.57 8 302904 19353 42299070
Treatment noncompliance 106.61 32.57 68 302844 37604 42280819
Ocular surface disease 104.89 32.57 37 302875 78 42318345
Spinal operation 104.18 32.57 139 302773 4081 42314342
Basal cell carcinoma 104.10 32.57 18 302894 22715 42295708
Inappropriate antidiuretic hormone secretion 103.57 32.57 3 302909 16538 42301885
Injury associated with device 103.18 32.57 83 302829 1314 42317109
Therapy partial responder 103.16 32.57 11 302901 20010 42298413
Facial discomfort 103.15 32.57 35 302877 62 42318361
Dysuria 102.85 32.57 46 302866 31050 42287373
Asthenopia 102.24 32.57 68 302844 788 42317635
Pericardial effusion 102.15 32.57 40 302872 29235 42289188
Troponin increased 102.10 32.57 9 302903 19053 42299370
Nephropathy toxic 102.10 32.57 4 302908 16834 42301589
Appendicitis 102.04 32.57 13 302899 20600 42297823
Splenomegaly 100.24 32.57 5 302907 17042 42301381
End stage renal disease 100.17 32.57 4 302908 16554 42301869
Abnormal behaviour 99.37 32.57 32 302880 26419 42292004
Metastases to liver 98.58 32.57 4 302908 16322 42302101
Obstructive airways disorder 98.39 32.57 27 302885 24732 42293691
Nightmare 98.05 32.57 28 302884 24984 42293439
Electrolyte imbalance 97.51 32.57 6 302906 17095 42301328
Sudden death 97.39 32.57 5 302907 16624 42301799
Anxiety 97.30 32.57 472 302440 118088 42200335
Small intestinal obstruction 97.24 32.57 6 302906 17055 42301368
Dandruff 96.92 32.57 47 302865 278 42318145
Mitral valve incompetence 96.44 32.57 5 302907 16484 42301939
Osteoarthritis 96.26 32.57 27 302885 24378 42294045
Blood albumin decreased 95.69 32.57 3 302909 15399 42303024
Cardiomyopathy 95.37 32.57 12 302900 19198 42299225
Arteriosclerosis 94.99 32.57 9 302903 17980 42300443
COVID-19 pneumonia 94.93 32.57 19 302893 21594 42296829
Nasal dryness 94.79 32.57 79 302833 1318 42317105
Skin texture abnormal 94.34 32.57 30 302882 38 42318385
Intentional self-injury 94.31 32.57 3 302909 15199 42303224
Ataxia 93.96 32.57 5 302907 16120 42302303
Hemiparesis 93.62 32.57 8 302904 17368 42301055
Liver function test increased 93.42 32.57 15 302897 19983 42298440
Urinary incontinence 93.20 32.57 20 302892 21648 42296775
Middle insomnia 92.87 32.57 185 302727 7648 42310775
Dizziness 92.52 32.57 1232 301680 248022 42070401
Oropharyngeal discomfort 92.37 32.57 130 302782 4019 42314404
Acute coronary syndrome 91.98 32.57 3 302909 14862 42303561
Lethargy 91.78 32.57 119 302793 46771 42271652
Sunburn 91.53 32.57 93 302819 2022 42316401
Throat clearing 91.03 32.57 56 302856 561 42317862
Blood potassium increased 91.01 32.57 12 302900 18524 42299899
Wheezing 90.93 32.57 684 302228 54097 42264326
Speech disorder 90.33 32.57 47 302865 29074 42289349
Atrial flutter 90.12 32.57 9 302903 17242 42301181
Hepatic steatosis 89.83 32.57 21 302891 21427 42296996
Palpitations 89.43 32.57 139 302773 50658 42267765
Subarachnoid haemorrhage 89.27 32.57 3 302909 14469 42303954
Aspergillus infection 88.98 32.57 6 302906 15831 42302592
Cutaneous T-cell lymphoma 88.56 32.57 89 302823 1909 42316514
Metastases to bone 88.19 32.57 4 302908 14805 42303618
Balance disorder 87.14 32.57 127 302785 47518 42270905
Periorbital pain 87.02 32.57 26 302886 22 42318401
Pustule 86.98 32.57 70 302842 1109 42317314
Brain oedema 86.66 32.57 8 302904 16319 42302104
Malnutrition 86.36 32.57 4 302908 14538 42303885
Osteonecrosis 86.32 32.57 7 302905 15858 42302565
Pneumothorax 85.79 32.57 30 302882 23513 42294910
Hallucination, auditory 85.40 32.57 5 302907 14859 42303564
Perioral dermatitis 85.39 32.57 39 302873 197 42318226
Blood potassium decreased 85.29 32.57 20 302892 20364 42298059
Sensitivity to weather change 85.09 32.57 88 302824 1955 42316468
Asthma 84.98 32.57 744 302168 61570 42256853
Cardiomegaly 84.40 32.57 10 302902 16756 42301667
Synovitis 84.33 32.57 7 302905 15560 42302863
Glomerular filtration rate decreased 84.20 32.57 9 302903 16342 42302081
Rosacea 83.90 32.57 73 302839 1295 42317128
Underdose 83.75 32.57 10 302902 16656 42301767
Cardiac failure acute 83.48 32.57 3 302909 13630 42304793
Diabetes mellitus inadequate control 83.15 32.57 7 302905 15383 42303040
Adverse event 82.98 32.57 32 302880 23608 42294815
Paranoia 82.84 32.57 4 302908 14022 42304401
Myasthenia gravis 82.80 32.57 9 302903 16128 42302295
Injection site nodule 82.74 32.57 89 302823 2072 42316351
Contraindicated product administered 82.62 32.57 38 302874 25234 42293189
Transient ischaemic attack 82.42 32.57 71 302841 33668 42284755
Aphasia 82.24 32.57 34 302878 24049 42294374
Lung disorder 80.73 32.57 135 302777 47788 42270635
Hepatic cirrhosis 79.20 32.57 21 302891 19681 42298742
Nasal operation 79.08 32.57 33 302879 128 42318295
Cholecystitis 79.04 32.57 3 302909 12985 42305438
Alopecia 78.97 32.57 414 302498 28862 42289561
Myocarditis 78.42 32.57 19 302893 18919 42299504
Keratitis 77.96 32.57 79 302833 1712 42316711
Toxic skin eruption 77.74 32.57 5 302907 13725 42304698
Body temperature decreased 76.67 32.57 7 302905 14406 42304017
Chronic obstructive pulmonary disease 76.27 32.57 214 302698 62900 42255523
Hyperthermia 76.19 32.57 3 302909 12571 42305852
Aspiration 75.94 32.57 17 302895 17869 42300554
Prostate cancer 75.91 32.57 125 302787 44518 42273905
Gait disturbance 74.80 32.57 400 302512 97600 42220823
Sinus congestion 74.66 32.57 158 302754 6822 42311601
Myositis 74.50 32.57 9 302903 14857 42303566
Anaphylactic reaction 74.25 32.57 118 302794 42625 42275798
Blood uric acid increased 74.13 32.57 11 302901 15536 42302887
Mood disorder due to a general medical condition 73.87 32.57 20 302892 6 42318417
Nervous system disorder 73.69 32.57 16 302896 17179 42301244
Blood cholesterol increased 73.32 32.57 50 302862 26691 42291732
Urosepsis 73.09 32.57 10 302902 15010 42303413
Joint stiffness 73.04 32.57 223 302689 12099 42306324
Periorbital inflammation 72.99 32.57 27 302885 69 42318354
Ventricular extrasystoles 72.59 32.57 6 302906 13384 42305039
Injection site hypoaesthesia 71.97 32.57 30 302882 116 42318307
Eyelid pain 71.96 32.57 32 302880 150 42318273
Amnesia 71.73 32.57 58 302854 28379 42290044
Mental status changes 71.53 32.57 118 302794 41997 42276426
Cardiac murmur 71.31 32.57 5 302907 12770 42305653
Heart rate increased 70.90 32.57 172 302740 53083 42265340
Paternal exposure during pregnancy 70.84 32.57 28 302884 91 42318332
Fluid retention 70.81 32.57 72 302840 31547 42286876
Gastric ulcer 70.56 32.57 21 302891 18241 42300182
Haemolytic anaemia 69.92 32.57 4 302908 12123 42306300
Productive cough 69.43 32.57 614 302298 50953 42267470
Psoriatic arthropathy 69.37 32.57 46 302866 24921 42293502
Pigmentation disorder 69.14 32.57 98 302814 3050 42315373
Body temperature increased 69.10 32.57 29 302883 20329 42298094
Cyanosis 68.61 32.57 12 302900 15019 42303404
Presyncope 68.16 32.57 37 302875 22350 42296073
Drainage 68.05 32.57 23 302889 40 42318383
Disturbance in attention 68.04 32.57 67 302845 29799 42288624
Blood triglycerides increased 67.70 32.57 15 302897 15881 42302542
Bacterial infection 67.70 32.57 59 302853 27820 42290603
Haemorrhage 67.66 32.57 213 302699 60350 42258073
Gastroenteritis 67.14 32.57 17 302895 16432 42301991
Skin atrophy 66.72 32.57 86 302826 2439 42315984
Muscle rigidity 66.51 32.57 5 302907 12054 42306369
Hyperthyroidism 66.45 32.57 11 302901 14330 42304093
Allergy to animal 66.43 32.57 44 302868 506 42317917
Ear discomfort 66.23 32.57 100 302812 3299 42315124
Tricuspid valve incompetence 66.18 32.57 3 302909 11110 42307313
Pseudomonas infection 65.88 32.57 16 302896 15907 42302516
Adrenal insufficiency 65.78 32.57 26 302886 18898 42299525
Osteoporosis 65.68 32.57 13 302899 14893 42303530
Staphylococcal sepsis 65.09 32.57 4 302908 11410 42307013
Osteomyelitis 65.07 32.57 24 302888 18199 42300224
Type 2 diabetes mellitus 64.83 32.57 25 302887 18446 42299977
Pharyngeal swelling 64.64 32.57 99 302813 3308 42315115
Blepharospasm 64.46 32.57 63 302849 1305 42317118
Prostatic specific antigen increased 64.42 32.57 20 302892 16905 42301518
SARS-CoV-2 test positive 64.24 32.57 165 302747 8095 42310328
Myalgia 63.36 32.57 997 301915 95083 42223340
Visual acuity reduced 62.86 32.57 23 302889 17527 42300896
Lipase increased 62.44 32.57 3 302909 10563 42307860
Metastases to lung 62.26 32.57 5 302907 11419 42307004
Chapped lips 62.24 32.57 53 302859 912 42317511
Drug eruption 62.13 32.57 44 302868 23031 42295392
Rales 62.10 32.57 5 302907 11395 42307028
Hospitalisation 62.07 32.57 804 302108 73526 42244897
Hepatomegaly 61.95 32.57 6 302906 11779 42306644
Haemorrhoids 61.93 32.57 22 302890 17075 42301348
Frequent bowel movements 61.45 32.57 38 302874 21369 42297054
Injection site discharge 61.00 32.57 41 302871 484 42317939
Withdrawal syndrome 60.83 32.57 15 302897 14760 42303663
Lip dry 60.41 32.57 67 302845 1616 42316807
Keratoconus 60.31 32.57 27 302885 129 42318294
Photophobia 59.88 32.57 159 302753 7960 42310463
Colitis ulcerative 59.30 32.57 59 302853 26116 42292307
Mania 59.24 32.57 4 302908 10543 42307880
General physical condition abnormal 59.11 32.57 108 302804 4181 42314242
Bronchiectasis 59.05 32.57 27 302885 17992 42300431
Supraventricular tachycardia 58.66 32.57 9 302903 12399 42306024
Knee operation 58.48 32.57 82 302830 2526 42315897
Squamous cell carcinoma of skin 58.43 32.57 10 302902 12716 42305707
Acarodermatitis 58.31 32.57 46 302866 707 42317716
Coronary artery stenosis 58.11 32.57 4 302908 10375 42308048
Metastases to central nervous system 57.95 32.57 4 302908 10351 42308072
Injection site exfoliation 57.72 32.57 20 302892 39 42318384
Gynaecomastia 57.43 32.57 10 302902 12557 42305866
Ill-defined disorder 57.29 32.57 22 302890 16274 42302149
Pneumonia bacterial 57.17 32.57 20 302892 15672 42302751
Hypertensive crisis 56.95 32.57 4 302908 10202 42308221
Generalised oedema 56.82 32.57 19 302893 15317 42303106
Fear 56.55 32.57 6 302906 10959 42307464
Faeces discoloured 56.53 32.57 25 302887 16989 42301434
Hepatitis C 56.46 32.57 4 302908 10129 42308294
Schizophrenia 56.45 32.57 5 302907 10545 42307878
Gastric haemorrhage 56.22 32.57 5 302907 10510 42307913
Face oedema 56.02 32.57 14 302898 13652 42304771
Decubitus ulcer 55.96 32.57 5 302907 10472 42307951
Large intestine perforation 55.43 32.57 3 302909 9533 42308890
Rebound nasal congestion 55.35 32.57 14 302898 0 42318423
Enterobiasis 55.35 32.57 14 302898 0 42318423
Hypotonia 55.18 32.57 3 302909 9496 42308927
Failure to thrive 54.65 32.57 3 302909 9419 42309004
Needle issue 54.62 32.57 161 302751 8566 42309857
Breath sounds abnormal 54.44 32.57 10 302902 12083 42306340
Electrocardiogram abnormal 53.77 32.57 5 302907 10140 42308283
Transfusion 53.60 32.57 6 302906 10508 42307915
Intestinal perforation 53.48 32.57 7 302905 10867 42307556
Urine output decreased 53.47 32.57 7 302905 10866 42307557
Injection site induration 53.46 32.57 92 302820 3395 42315028
Blood test abnormal 53.33 32.57 13 302899 12893 42305530
Injury 53.25 32.57 48 302864 22268 42296155
Bronchospasm 53.21 32.57 13 302899 12872 42305551
Skin depigmentation 53.07 32.57 36 302876 432 42317991
Skin hypopigmentation 52.83 32.57 34 302878 371 42318052
Staphylococcal bacteraemia 52.72 32.57 8 302904 11113 42307310
Heart rate irregular 52.67 32.57 24 302888 16026 42302397
Lung infiltration 52.41 32.57 17 302895 13972 42304451
Iron deficiency 52.34 32.57 8 302904 11053 42307370
Bladder cancer 52.15 32.57 28 302884 17019 42301404
Candida infection 52.15 32.57 46 302866 21564 42296859
Dyspnoea exertional 52.14 32.57 182 302730 49966 42268457
Klebsiella infection 51.82 32.57 9 302903 11323 42307100
Molluscum contagiosum 51.65 32.57 32 302880 325 42318098
Nasal pruritus 51.61 32.57 26 302886 169 42318254
Eye operation 51.18 32.57 38 302874 531 42317892
Blood sodium decreased 51.08 32.57 33 302879 18129 42300294
Hyperhidrosis 50.98 32.57 405 302507 90107 42228316
Large intestine polyp 50.65 32.57 4 302908 9261 42309162
Eyelid thickening 50.40 32.57 14 302898 6 42318417
Renal disorder 50.34 32.57 80 302832 28900 42289523
Neurological symptom 50.19 32.57 6 302906 9985 42308438
Aortic stenosis 50.06 32.57 3 302909 8742 42309681
Product administered to patient of inappropriate age 50.03 32.57 107 302805 4654 42313769
Nephrotic syndrome 49.88 32.57 3 302909 8715 42309708
Emotional distress 49.87 32.57 26 302886 16067 42302356
Pneumonia fungal 49.86 32.57 4 302908 9142 42309281
Oral candidiasis 49.73 32.57 20 302892 14385 42304038
Sinus headache 49.72 32.57 52 302860 1171 42317252
Kidney transplant rejection 49.65 32.57 3 302909 8680 42309743
Micturition urgency 49.14 32.57 12 302900 11886 42306537
Hiccups 48.87 32.57 13 302899 12158 42306265
Cardiovascular disorder 48.75 32.57 17 302895 13348 42305075
Mobility decreased 48.61 32.57 112 302800 35194 42283229
Enteritis 48.57 32.57 9 302903 10807 42307616
Left ventricular hypertrophy 48.32 32.57 5 302907 9314 42309109
Renal cyst 48.10 32.57 7 302905 10032 42308391
Product administration error 48.05 32.57 36 302876 18307 42300116
Escherichia infection 48.04 32.57 11 302901 11385 42307038
Respiratory rate increased 48.01 32.57 10 302902 11052 42307371
Mental impairment 47.88 32.57 14 302898 12303 42306120
Platelet count increased 47.87 32.57 9 302903 10694 42307729
Gastric disorder 47.37 32.57 13 302899 11909 42306514
Red blood cell sedimentation rate increased 47.37 32.57 7 302905 9917 42308506
Swelling face 46.81 32.57 346 302566 27208 42291215
Dark circles under eyes 46.70 32.57 19 302893 68 42318355
Chromaturia 46.43 32.57 28 302884 15961 42302462
Erectile dysfunction 45.95 32.57 66 302846 24847 42293576
Skin mass 45.82 32.57 104 302808 4712 42313711
Post procedural haemorrhage 45.78 32.57 6 302906 9306 42309117
Back pain 45.77 32.57 720 302192 141056 42177367
Swollen tongue 45.68 32.57 50 302862 21181 42297242
Polyuria 45.67 32.57 8 302904 10003 42308420
Shoulder operation 45.42 32.57 54 302858 1407 42317016
Lip erythema 45.28 32.57 20 302892 92 42318331
Incorrect dose administered by product 45.27 32.57 17 302895 46 42318377
Blood calcium increased 45.25 32.57 4 302908 8450 42309973
Off label use 44.44 32.57 3921 298991 634414 41684009
Adverse drug reaction 44.43 32.57 128 302784 37306 42281117
Sinonasal obstruction 44.26 32.57 23 302889 161 42318262
Anal incontinence 43.90 32.57 7 302905 9374 42309049
Device dislocation 43.90 32.57 3 302909 7828 42310595
Vitiligo 43.78 32.57 49 302863 1194 42317229
Device operational issue 43.77 32.57 26 302886 243 42318180
Intentional product misuse 43.74 32.57 650 302262 61250 42257173
Apnoea 43.71 32.57 3 302909 7800 42310623
Coronary artery occlusion 43.68 32.57 12 302900 10985 42307438
Psoriasis 43.67 32.57 533 302379 48071 42270352
Sleep disorder due to general medical condition, insomnia type 43.55 32.57 53 302859 1416 42317007
Injection site eczema 43.49 32.57 11 302901 0 42318423
Exfoliative rash 43.49 32.57 68 302844 2314 42316109
Mood altered 43.47 32.57 171 302741 10547 42307876
Pollakiuria 43.13 32.57 58 302854 22447 42295976
Allergy to chemicals 43.02 32.57 20 302892 106 42318317
Bundle branch block right 42.95 32.57 4 302908 8102 42310321
Post procedural complication 42.62 32.57 18 302894 12572 42305851
Coordination abnormal 42.58 32.57 4 302908 8046 42310377
Blood lactic acid increased 42.50 32.57 4 302908 8035 42310388
Eczema asteatotic 42.43 32.57 31 302881 422 42318001
Lung neoplasm malignant 42.42 32.57 44 302868 19103 42299320
Embolism 42.25 32.57 6 302906 8757 42309666
Pain 42.21 32.57 2136 300776 242712 42075711
Diffuse large B-cell lymphoma 42.17 32.57 8 302904 9446 42308977
Injection site hypersensitivity 41.96 32.57 30 302882 394 42318029
Asphyxia 41.82 32.57 5 302907 8321 42310102
Spinal osteoarthritis 41.75 32.57 6 302906 8680 42309743
Cardiac disorder 41.75 32.57 192 302720 48740 42269683
Central nervous system lesion 41.39 32.57 4 302908 7866 42310557
Skin erosion 41.37 32.57 74 302838 2817 42315606
Abscess 41.30 32.57 25 302887 14223 42304200
Facial paralysis 40.89 32.57 19 302893 12544 42305879
Nasal inflammation 40.78 32.57 30 302882 413 42318010
Eye ulcer 40.64 32.57 15 302897 38 42318385
Eyelid infection 40.37 32.57 15 302897 39 42318384
Skin warm 40.07 32.57 72 302840 2751 42315672
Mydriasis 40.03 32.57 7 302905 8763 42309660
Skin wound 39.96 32.57 36 302876 670 42317753
Apathy 39.96 32.57 6 302906 8400 42310023
Anhedonia 39.87 32.57 4 302908 7636 42310787
Neuralgia 39.81 32.57 76 302836 25571 42292852
Paranasal sinus hypersecretion 38.96 32.57 45 302867 1136 42317287
Lack of administration site rotation 38.87 32.57 17 302895 76 42318347
Spinal compression fracture 38.84 32.57 4 302908 7479 42310944
Infective pulmonary exacerbation of cystic fibrosis 38.53 32.57 5 302907 7813 42310610
Diverticulitis 38.49 32.57 64 302848 22709 42295714
Endocarditis 38.34 32.57 6 302906 8146 42310277
Tinea infection 38.19 32.57 27 302885 348 42318075
Maternal exposure during pregnancy 38.18 32.57 3 302909 6975 42311448
Cerebral ischaemia 38.05 32.57 3 302909 6956 42311467
Dermatitis bullous 38.05 32.57 7 302905 8449 42309974
Immune thrombocytopenia 38.03 32.57 16 302896 11200 42307223
Blood magnesium decreased 37.93 32.57 5 302907 7721 42310702
Vitamin D deficiency 37.83 32.57 6 302906 8067 42310356
Squamous cell carcinoma 37.32 32.57 23 302889 12959 42305464
Madarosis 37.24 32.57 30 302882 476 42317947
Adenovirus infection 37.05 32.57 3 302909 6806 42311617
Atopic keratoconjunctivitis 36.94 32.57 10 302902 3 42318420
Acute generalised exanthematous pustulosis 36.83 32.57 8 302904 8587 42309836
Oesophageal discomfort 36.73 32.57 17 302895 89 42318334
Drug ineffective for unapproved indication 36.72 32.57 495 302417 45668 42272755
Hypopnoea 36.62 32.57 6 302906 7876 42310547
Vitreous floaters 36.59 32.57 88 302824 4142 42314281
Tinnitus 36.54 32.57 96 302816 28842 42289581
Encephalitis 36.36 32.57 10 302902 9148 42309275
Proctalgia 36.28 32.57 4 302908 7089 42311334
Motor dysfunction 36.11 32.57 7 302905 8139 42310284
Croup infectious 35.77 32.57 30 302882 505 42317918
Eczema herpeticum 35.66 32.57 24 302888 284 42318139
Circumoral swelling 35.58 32.57 9 302903 0 42318423
Sweating fever 35.58 32.57 9 302903 0 42318423
Abdominal pain lower 35.35 32.57 21 302891 12071 42306352
Gastroenteritis viral 35.04 32.57 133 302779 8066 42310357
Salivary hypersecretion 34.93 32.57 17 302895 10926 42307497
Potentiating drug interaction 34.78 32.57 3 302909 6465 42311958
Increased viscosity of upper respiratory secretion 34.73 32.57 25 302887 332 42318091
Peripheral arterial occlusive disease 34.61 32.57 4 302908 6834 42311589
Hemiplegia 34.45 32.57 7 302905 7872 42310551
Nephrolithiasis 34.17 32.57 140 302772 36690 42281733
Nocturia 34.07 32.57 22 302890 12090 42306333
Steroid dependence 33.86 32.57 4 302908 6718 42311705
Oesophagitis 33.82 32.57 35 302877 15212 42303211
Incorrect dose administered by device 33.77 32.57 66 302846 2690 42315733
Ecchymosis 33.66 32.57 7 302905 7745 42310678
Vasculitis 33.66 32.57 49 302863 18345 42300078
Impaired healing 33.65 32.57 43 302869 17010 42301413
Hypereosinophilic syndrome 33.48 32.57 27 302885 429 42317994
Discharge 33.45 32.57 30 302882 555 42317868
Pulmonary vasculitis 33.44 32.57 3 302909 6263 42312160
Diarrhoea haemorrhagic 33.38 32.57 7 302905 7700 42310723
Gout 33.24 32.57 96 302816 27959 42290464
Neuritis 33.14 32.57 3 302909 6217 42312206
Brain injury 33.05 32.57 7 302905 7648 42310775
Muscle spasms 33.04 32.57 422 302490 85622 42232801
Dermatitis contact 33.02 32.57 88 302824 4415 42314008
Lip pruritus 32.91 32.57 12 302900 29 42318394
Alopecia areata 32.89 32.57 24 302888 326 42318097

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pruritus 49903.91 22.76 34566 609157 546994 109398582
Injection site pain 39527.29 22.76 19663 624060 158259 109787317
Dry skin 36599.42 22.76 15984 627739 91669 109853907
Product use in unapproved indication 32169.09 22.76 23956 619767 423421 109522155
Eczema 28674.27 22.76 11983 631740 60310 109885266
Exposure via skin contact 20056.78 22.76 5950 637773 7197 109938379
Product dose omission in error 16964.56 22.76 6031 637692 17481 109928095
Inappropriate schedule of product administration 16650.95 22.76 11826 631897 191811 109753765
Skin exfoliation 16375.91 22.76 8643 635080 79008 109866568
Dry eye 15292.46 22.76 7142 636581 48651 109896925
Accidental exposure to product 14932.30 22.76 6794 636929 43214 109902362
Therapeutic response shortened 13846.30 22.76 5529 638194 24054 109921522
Injection site swelling 13695.70 22.76 6839 636884 54951 109890625
Incorrect dose administered 13347.90 22.76 8009 635714 95632 109849944
Product dose omission issue 13338.17 22.76 12578 631145 309204 109636372
Rash 12942.94 22.76 19550 624173 801414 109144162
Eye pruritus 11943.37 22.76 5123 638600 27652 109917924
Skin fissures 10777.12 22.76 4378 639345 20080 109925496
Skin burning sensation 10082.27 22.76 4042 639681 17783 109927793
Injection site erythema 9371.03 22.76 6183 637540 87993 109857583
Ocular hyperaemia 7899.58 22.76 4074 639649 35212 109910364
Sleep disorder due to a general medical condition 7764.82 22.76 4430 639293 47682 109897894
Rash erythematous 7544.00 22.76 5125 638598 76707 109868869
Eye irritation 6652.97 22.76 3444 640279 30008 109915568
Therapeutic response decreased 6600.42 22.76 5042 638681 91457 109854119
Rebound eczema 6009.71 22.76 1519 642204 333 109945243
Erythema 5656.99 22.76 7690 636033 283757 109661819
Rebound atopic dermatitis 5568.39 22.76 1458 642265 583 109944993
Injection site pruritus 5463.56 22.76 3516 640207 47742 109897834
Condition aggravated 5377.13 22.76 12630 631093 722206 109223370
Product preparation error 5347.57 22.76 2108 641615 8771 109936805
Injection site urticaria 4901.36 22.76 2265 641458 14950 109930626
Skin haemorrhage 4890.00 22.76 2540 641183 22287 109923289
Injection site rash 4736.37 22.76 2439 641284 20980 109924596
Impaired quality of life 4494.30 22.76 2561 641162 27456 109918120
Injection site bruising 4491.32 22.76 3113 640610 48150 109897426
Rash macular 4224.54 22.76 2695 641028 35991 109909585
Conjunctivitis 4192.26 22.76 2553 641170 31239 109914337
Skin swelling 3986.39 22.76 1570 642153 6510 109939066
Rebound effect 3945.35 22.76 1861 641862 12945 109932631
Skin weeping 3870 22.76 1258 642465 2477 109943099
Acute kidney injury 3474.61 22.76 43 643680 635387 109310189
Intentional dose omission 2951.35 22.76 1693 642030 18387 109927189
Vision blurred 2856.24 22.76 3636 640087 125386 109820190
Arthralgia 2846.98 22.76 10468 633255 769164 109176412
Toxicity to various agents 2748.44 22.76 8 643715 480547 109465029
Scratch 2723.31 22.76 1386 642337 11593 109933983
Nasal congestion 2698.74 22.76 3090 640633 95192 109850384
Illness 2639.31 22.76 2805 640918 79366 109866210
Skin irritation 2576.66 22.76 1442 642281 14877 109930699
Drug interaction 2553.79 22.76 79 643644 500104 109445472
Anaemia 2550.10 22.76 161 643562 546925 109398651
Dermatitis atopic 2409.21 22.76 1624 642099 23917 109921659
Product prescribing issue 2384.28 22.76 1261 642462 11511 109934065
Lacrimation increased 2378.98 22.76 1736 641987 29214 109916362
Cough 2280.54 22.76 6871 636852 454770 109490806
Oral herpes 2229.71 22.76 1777 641946 34303 109911273
Death 2109.96 22.76 720 643003 698149 109247427
Hypotension 2106.62 22.76 280 643443 523569 109422007
Infusion related reaction 2094.35 22.76 23 643700 381139 109564437
Confusional state 2042.25 22.76 188 643535 468492 109477084
Neutropenia 1980.24 22.76 41 643682 374579 109570997
Drug intolerance 1963.40 22.76 97 643626 406415 109539161
Rash pruritic 1893.29 22.76 2585 641138 95484 109850092
Injection site mass 1890.32 22.76 1380 642343 23233 109922343
Thrombocytopenia 1860.85 22.76 34 643689 348851 109596725
Eye discharge 1828.30 22.76 932 642791 7822 109937754
Injection site reaction 1826.58 22.76 2418 641305 86652 109858924
Diarrhoea 1816.37 22.76 2391 641332 1137114 108808462
Nausea 1813.21 22.76 2751 640972 1232939 108712637
Febrile neutropenia 1806.11 22.76 6 643717 316761 109628815
COVID-19 1777.77 22.76 4209 639514 240851 109704725
Vomiting 1775.83 22.76 1616 642107 909059 109036517
Product storage error 1757.09 22.76 1257 642466 20471 109925105
Rhinorrhoea 1649.62 22.76 2480 641243 100186 109845390
General physical health deterioration 1593.46 22.76 278 643445 425017 109520559
Extra dose administered 1583.28 22.76 948 642775 11211 109934365
Synovitis 1517.09 22.76 14 643709 274078 109671498
Drug ineffective 1494.80 22.76 14422 629301 1506118 108439458
Eyelids pruritus 1440.30 22.76 499 643224 1298 109944278
Hepatic enzyme increased 1434.68 22.76 115 643608 320777 109624799
Hypertension 1426.92 22.76 592 643131 509492 109436084
Injection site irritation 1417.25 22.76 653 643070 4271 109941305
Sleep disorder 1375.74 22.76 3352 640371 195292 109750284
Eye swelling 1367.70 22.76 1295 642428 31753 109913823
Asthenia 1355.52 22.76 1211 642512 687788 109257788
Eye pain 1333.90 22.76 1551 642172 48548 109897028
Completed suicide 1333.80 22.76 14 643709 242367 109703209
Anosmia 1302.03 22.76 845 642878 11627 109933949
Eyelid margin crusting 1272.59 22.76 469 643254 1547 109944029
Hand deformity 1235.00 22.76 6 643717 218500 109727076
Abdominal pain 1231.68 22.76 730 642993 512259 109433317
Erythema of eyelid 1230.39 22.76 552 643171 3363 109942213
Overdose 1225.52 22.76 28 643695 233766 109711810
Drug effect less than expected 1213.40 22.76 668 643055 6652 109938924
Pemphigus 1206.89 22.76 7 643716 214563 109731013
Oedema peripheral 1191.71 22.76 233 643490 328427 109617149
Disease progression 1184.86 22.76 56 643667 243978 109701598
Eyelid skin dryness 1181.76 22.76 344 643379 365 109945211
Treatment failure 1175.85 22.76 123 643600 277111 109668465
Contraindicated product administered 1173.83 22.76 67 643656 248200 109697376
Sepsis 1172.43 22.76 239 643484 327107 109618469
Hyponatraemia 1169.34 22.76 19 643704 217634 109727942
Pancytopenia 1163.22 22.76 10 643713 209603 109735973
Skin discolouration 1152.50 22.76 1425 642298 47621 109897955
Haemoglobin decreased 1152.24 22.76 75 643648 248652 109696924
Lack of injection site rotation 1124.33 22.76 372 643351 794 109944782
Intentional product use issue 1101.95 22.76 91 643632 247815 109697761
Pericarditis 1087.85 22.76 43 643680 219071 109726505
Systemic lupus erythematosus 1075.63 22.76 114 643609 254224 109691352
Glossodynia 1055.42 22.76 58 643665 221946 109723630
Platelet count decreased 1054.22 22.76 74 643649 230369 109715207
Periorbital swelling 1051.49 22.76 552 643171 4953 109940623
White blood cell count decreased 1039.79 22.76 77 643646 229313 109716263
Swelling of eyelid 1034.15 22.76 582 643141 6071 109939505
C-reactive protein increased 1020.46 22.76 62 643661 217857 109727719
Skin discomfort 1019.69 22.76 404 643319 1706 109943870
Injection site vesicles 1018.78 22.76 505 643218 3966 109941610
Injection site discomfort 1013.82 22.76 582 643141 6325 109939251
Drug abuse 1012.98 22.76 3 643720 177408 109768168
Rheumatoid arthritis 1002.37 22.76 254 643469 299359 109646217
Pneumonia 986.80 22.76 2287 641436 874427 109071149
Arthropathy 984.80 22.76 232 643491 287290 109658286
Renal failure 983.05 22.76 92 643631 226482 109719094
Fear of injection 982.76 22.76 625 643098 8286 109937290
Malignant neoplasm progression 980.13 22.76 6 643717 174561 109771015
Decreased appetite 978.06 22.76 801 642922 475045 109470531
Dermatitis 971.62 22.76 994 642729 26843 109918733
Respiratory failure 954.36 22.76 80 643643 215252 109730324
Cardiac arrest 952.33 22.76 46 643677 196707 109748869
Hypokalaemia 947.88 22.76 24 643699 182424 109763152
Blood creatinine increased 939.19 22.76 27 643696 182862 109762714
Alanine aminotransferase increased 936.93 22.76 29 643694 183744 109761832
Lower respiratory tract infection 929.68 22.76 150 643573 242956 109702620
Product use issue 926.96 22.76 3932 639791 307763 109637813
Helicobacter infection 895.05 22.76 38 643685 181839 109763737
Blepharitis 882.44 22.76 461 643262 4091 109941485
Impaired healing 858.40 22.76 78 643645 196639 109748937
Eye disorder 857.96 22.76 947 642776 27959 109917617
Type 2 diabetes mellitus 855.95 22.76 42 643681 177190 109768386
Pulmonary embolism 839.04 22.76 124 643599 214350 109731226
Fall 838.55 22.76 1389 642334 602093 109343483
Pain of skin 838.53 22.76 790 642933 19239 109926337
Tachycardia 833.40 22.76 155 643568 226490 109719086
Liver injury 825.92 22.76 9 643714 150404 109795172
Stomatitis 818.01 22.76 276 643447 269966 109675610
Multiple organ dysfunction syndrome 815.83 22.76 13 643710 151697 109793879
Oedema 808.61 22.76 127 643596 209849 109735727
Psoriatic arthropathy 799.90 22.76 101 643622 196660 109748916
Aspartate aminotransferase increased 798.54 22.76 30 643693 159906 109785670
Leukopenia 794.91 22.76 14 643709 148777 109796799
Septic shock 784.96 22.76 30 643693 157498 109788078
Dehydration 783.08 22.76 323 643400 279188 109666388
Renal impairment 777.68 22.76 92 643631 188353 109757223
Musculoskeletal pain 771.27 22.76 83 643640 182940 109762636
Folliculitis 769.15 22.76 53 643670 167600 109777976
Gastrointestinal haemorrhage 769.15 22.76 49 643674 165469 109780107
Constipation 768.07 22.76 576 643147 357210 109588366
Bradycardia 763.55 22.76 33 643690 155484 109790092
Muscle injury 757.44 22.76 12 643711 140795 109804781
Intentional overdose 752.08 22.76 3 643720 132498 109813078
Wound 751.48 22.76 216 643507 234221 109711355
Pleural effusion 750.36 22.76 80 643643 177629 109767947
Rheumatoid factor positive 747.08 22.76 3 643720 131637 109813939
Injection site discolouration 736.76 22.76 527 643196 8576 109937000
Injection site haemorrhage 735.03 22.76 934 642789 32094 109913482
Blood cholesterol increased 734.06 22.76 102 643621 184683 109760893
Hordeolum 730.12 22.76 417 643306 4484 109941092
Oropharyngeal pain 729.15 22.76 2080 641643 133196 109812380
Injury 727.89 22.76 88 643635 177177 109768399
Hyperkalaemia 720.45 22.76 14 643709 135782 109809794
Delirium 720.10 22.76 13 643710 135012 109810564
Irritable bowel syndrome 711.40 22.76 67 643656 164148 109781428
C-reactive protein abnormal 710.99 22.76 8 643715 129687 109815889
Osteoarthritis 704.20 22.76 110 643613 182513 109763063
Joint swelling 702.75 22.76 929 642794 441916 109503660
Malaise 701.95 22.76 1820 641903 669999 109275577
Cardiac failure 692.60 22.76 127 643596 187499 109758077
Mobility decreased 680.31 22.76 265 643458 237157 109708419
Ill-defined disorder 676.82 22.76 65 643658 156788 109788788
Interstitial lung disease 676.07 22.76 32 643691 139302 109806274
Fibromyalgia 674.99 22.76 96 643627 170813 109774763
Device use issue 670.71 22.76 361 643362 3423 109942153
Eyelid irritation 665.86 22.76 250 643473 881 109944695
Injection site warmth 665.33 22.76 653 643070 16752 109928824
Eyelid rash 662.93 22.76 201 643522 275 109945301
Eye inflammation 658.71 22.76 494 643229 8677 109936899
Therapeutic response unexpected 647.69 22.76 746 642977 23097 109922479
Therapy non-responder 638.76 22.76 81 643642 157226 109788350
Intercepted product storage error 638.32 22.76 219 643504 547 109945029
Cardio-respiratory arrest 635.64 22.76 7 643716 115829 109829747
Drug-induced liver injury 634.46 22.76 13 643710 120054 109825522
Neutrophil count decreased 616.71 22.76 19 643704 120922 109824654
Liver disorder 616.24 22.76 58 643665 142185 109803391
Acne 612.62 22.76 861 642862 32659 109912917
Electrocardiogram QT prolonged 610.28 22.76 4 643719 108956 109836620
Scab 604.33 22.76 548 643175 12688 109932888
Joint range of motion decreased 604.27 22.76 24 643699 121808 109823768
Rhabdomyolysis 603.05 22.76 22 643701 120379 109825197
Seizure 602.83 22.76 266 643457 220919 109724657
Neurodermatitis 600.17 22.76 308 643415 2624 109942952
Weight decreased 598.47 22.76 1134 642589 466923 109478653
Depressed level of consciousness 589.94 22.76 13 643710 112265 109833311
Coma 588.76 22.76 22 643701 117847 109827729
Deep vein thrombosis 587.92 22.76 64 643659 139823 109805753
Atrial fibrillation 587.80 22.76 301 643422 229341 109716235
Blood pressure increased 581.81 22.76 395 643328 257978 109687598
Muscular weakness 581.03 22.76 364 643359 248104 109697472
Pyrexia 577.73 22.76 2979 640744 895286 109050290
Hypoglycaemia 575.40 22.76 23 643700 116081 109829495
Fatigue 573.83 22.76 4438 639285 1211520 108734056
Bursitis 573.53 22.76 49 643674 129869 109815707
Sensitive skin 572.28 22.76 323 643400 3389 109942187
Product administered at inappropriate site 569.33 22.76 368 643355 5025 109940551
Surgery 562.47 22.76 925 642798 40358 109905218
Medication error 562.44 22.76 10 643713 105356 109840220
Obesity 556.58 22.76 24 643699 113327 109832249
Somnolence 555.22 22.76 547 643176 296902 109648674
Rectal haemorrhage 552.21 22.76 37 643686 119796 109825780
Injection site dryness 551.46 22.76 189 643534 470 109945106
Eczema eyelids 546.59 22.76 169 643554 258 109945318
Influenza 544.42 22.76 2187 641536 166914 109778662
Sneezing 536.84 22.76 789 642934 31195 109914381
Nasopharyngitis 534.29 22.76 4027 639696 390334 109555242
Suicide attempt 520.93 22.76 18 643705 103376 109842200
Ocular discomfort 517.90 22.76 416 643307 8117 109937459
Mucosal inflammation 517.88 22.76 8 643715 96133 109849443
Hypoxia 508.48 22.76 74 643649 129441 109816135
Secretion discharge 501.12 22.76 604 643119 19640 109925936
Hypercholesterolaemia 496.09 22.76 6 643717 90831 109854745
Prescribed overdose 491.59 22.76 3 643720 87578 109857998
Eye infection 489.61 22.76 509 643214 14009 109931567
Nasal obstruction 485.58 22.76 280 643443 3070 109942506
Discomfort 481.53 22.76 2496 641227 212211 109733365
Syncope 480.02 22.76 292 643431 202244 109743332
International normalised ratio increased 477.20 22.76 5 643718 86767 109858809
Ascites 475.30 22.76 14 643709 92794 109852782
Hepatitis 474.80 22.76 10 643713 90044 109855532
Drug hypersensitivity 474.60 22.76 1229 642494 452861 109492715
Stress 468.19 22.76 1514 642209 103834 109841742
Musculoskeletal stiffness 467.54 22.76 564 643159 279258 109666318
Gastrointestinal disorder 465.40 22.76 433 643290 241519 109704057
Lactic acidosis 464.65 22.76 17 643706 92794 109852782
Pulmonary fibrosis 462.96 22.76 34 643689 102008 109843568
Adverse event 461.79 22.76 48 643675 108761 109836815
Unintentional use for unapproved indication 450.66 22.76 143 643580 250 109945326
Epilepsy 447.27 22.76 36 643687 100173 109845403
Abdominal discomfort 445.34 22.76 1023 642700 392835 109552741
Depression 445.10 22.76 725 642998 316610 109628966
Encephalopathy 439.79 22.76 6 643717 81049 109864527
Hepatic function abnormal 438.10 22.76 19 643704 89276 109856300
Peripheral venous disease 437.06 22.76 11 643712 84106 109861470
Off label use of device 436.12 22.76 148 643575 353 109945223
Swollen joint count increased 434.46 22.76 11 643712 83650 109861926
Wound infection 432.38 22.76 34 643689 96431 109849145
Cardiac failure congestive 431.69 22.76 169 643554 150831 109794745
Eyelid exfoliation 429.26 22.76 131 643592 186 109945390
Agitation 420.43 22.76 75 643648 112976 109832600
Periorbital irritation 418.02 22.76 107 643616 30 109945546
Lung disorder 415.03 22.76 268 643455 179779 109765797
Liver function test increased 414.96 22.76 25 643698 88523 109857053
Drug reaction with eosinophilia and systemic symptoms 414.61 22.76 14 643709 82081 109863495
Blood bilirubin increased 406.35 22.76 7 643716 75965 109869611
Tremor 404.38 22.76 349 643374 201883 109743693
Initial insomnia 403.10 22.76 393 643330 9996 109935580
Blood pressure systolic increased 399.56 22.76 20 643703 82971 109862605
Visual impairment 392.13 22.76 1687 642036 132741 109812835
Sedation 388.02 22.76 3 643720 69680 109875896
Hallucination 386.66 22.76 63 643660 101369 109844207
Haematochezia 385.96 22.76 98 643625 115426 109830150
Acute myocardial infarction 385.60 22.76 26 643697 83751 109861825
Neuropathy peripheral 383.92 22.76 289 643434 178988 109766588
Cognitive disorder 380.84 22.76 35 643688 87476 109858100
Product quality issue 377.40 22.76 17 643706 77282 109868294
Haematuria 375.57 22.76 28 643695 82977 109862599
Night sweats 374.76 22.76 155 643568 133828 109811748
Pneumonia aspiration 374.50 22.76 25 643698 81208 109864368
Injection site inflammation 371.91 22.76 270 643453 4501 109941075
Myocardial infarction 371.43 22.76 342 643381 191741 109753835
Blood creatine phosphokinase increased 370.69 22.76 12 643711 73065 109872511
Hyperglycaemia 370.38 22.76 34 643689 85056 109860520
Live birth 369.18 22.76 7 643716 69477 109876099
Hospitalisation 368.91 22.76 1726 641997 140767 109804809
Urticaria 368.28 22.76 3140 640583 315717 109629859
Red blood cell sedimentation rate increased 367.25 22.76 22 643701 78280 109867296
Suicidal ideation 365.66 22.76 55 643668 93882 109851694
Oesophageal food impaction 361.92 22.76 133 643590 434 109945142
Hand dermatitis 360.13 22.76 143 643580 608 109944968
Eye allergy 357.47 22.76 157 643566 902 109944674
Melaena 353.45 22.76 10 643713 68747 109876829
Hepatic failure 353.35 22.76 10 643713 68729 109876847
Haematocrit decreased 349.92 22.76 7 643716 66110 109879466
Liver function test abnormal 347.35 22.76 12 643711 68938 109876638
Injection site exfoliation 347.19 22.76 120 643603 309 109945267
Coronary artery disease 346.01 22.76 17 643706 71673 109873903
Blood pressure fluctuation 345.03 22.76 23 643700 74801 109870775
Food allergy 344.79 22.76 499 643224 19449 109926127
Hypomagnesaemia 334.21 22.76 3 643720 60367 109885209
Transaminases increased 330.43 22.76 8 643715 63382 109882194
Loss of consciousness 329.58 22.76 394 643329 195912 109749664
Cholestasis 329.40 22.76 10 643713 64508 109881068
Serotonin syndrome 327.18 22.76 3 643720 59150 109886426
Chest pain 327.02 22.76 1110 642613 375265 109570311
Hepatotoxicity 326.72 22.76 9 643714 63391 109882185
Respiratory tract congestion 324.18 22.76 617 643106 30240 109915336
Blood pressure decreased 322.11 22.76 133 643590 114958 109830618
Grip strength decreased 321.29 22.76 43 643680 80131 109865445
Acute respiratory failure 317.30 22.76 34 643689 75226 109870350
Wrong technique in device usage process 315.60 22.76 286 643437 6615 109938961
Symptom recurrence 314.02 22.76 244 643479 4528 109941048
Chronic kidney disease 312.79 22.76 38 643685 76253 109869323
Blood alkaline phosphatase increased 312.38 22.76 27 643696 70908 109874668
Dyspnoea 311.63 22.76 8536 635187 1098336 108847240
Dysarthria 310.21 22.76 57 643666 84064 109861512
Amnesia 307.89 22.76 114 643609 105294 109840282
Jaundice 303.08 22.76 9 643714 59227 109886349
Orthostatic hypotension 300.72 22.76 22 643701 66227 109879349
Toxic epidermal necrolysis 300.23 22.76 6 643717 56721 109888855
Gamma-glutamyltransferase increased 297.63 22.76 14 643709 61295 109884281
Sleep disorder due to general medical condition, insomnia type 297.41 22.76 121 643602 105522 109840054
Cardiogenic shock 295.99 22.76 8 643715 57330 109888246
Hyposmia 295.30 22.76 141 643582 1010 109944566
Hepatic cirrhosis 294.40 22.76 27 643696 67599 109877977
Respiratory arrest 294.19 22.76 10 643713 58289 109887287
Unresponsive to stimuli 292.98 22.76 20 643703 63770 109881806
Plasma cell myeloma 291.21 22.76 19 643704 62917 109882659
Upper-airway cough syndrome 290.75 22.76 408 643315 15449 109930127
Therapeutic product effect decreased 290.41 22.76 617 643106 243699 109701877
Altered state of consciousness 290.39 22.76 10 643713 57616 109887960
Perioral dermatitis 289.94 22.76 121 643602 600 109944976
Dyspepsia 287.09 22.76 416 643307 190549 109755027
Rash maculo-papular 285.37 22.76 45 643678 74177 109871399
Hypothyroidism 285.31 22.76 42 643681 72857 109872719
Oxygen saturation decreased 284.41 22.76 296 643427 156686 109788890
Cytomegalovirus infection 283.30 22.76 7 643716 54437 109891139
Underdose 283.14 22.76 23 643700 63531 109882045
Lymphocyte count decreased 281.40 22.76 12 643711 57231 109888345
Red blood cell count decreased 279.93 22.76 29 643694 65894 109879682
Drug resistance 276.52 22.76 12 643711 56362 109889214
Pharyngitis streptococcal 275.88 22.76 363 643360 12914 109932662
Tubulointerstitial nephritis 275.03 22.76 9 643714 54275 109891301
Pulmonary oedema 272.65 22.76 122 643601 100537 109845039
Colitis 272.51 22.76 127 643596 102196 109843380
Hepatic cytolysis 272.44 22.76 11 643712 55042 109890534
Blood urea increased 271.90 22.76 11 643712 54946 109890630
Disorientation 269.12 22.76 44 643679 70627 109874949
Acute respiratory distress syndrome 268.88 22.76 9 643714 53189 109892387
Upper gastrointestinal haemorrhage 266.34 22.76 5 643718 50091 109895485
Urinary retention 266.22 22.76 43 643680 69640 109875936
Angioedema 265.83 22.76 120 643603 98380 109847196
Myalgia 264.04 22.76 2204 641519 220177 109725399
Dizziness 263.88 22.76 2694 641029 695499 109250077
Generalised tonic-clonic seizure 263.78 22.76 13 643710 54667 109890909
SARS-CoV-2 test positive 263.12 22.76 403 643320 16532 109929044
Pancreatitis 261.89 22.76 108 643615 93425 109852151
Haematemesis 261.64 22.76 22 643701 59086 109886490
Skin disorder 261.03 22.76 690 643033 42223 109903353
Blood glucose increased 260.77 22.76 232 643491 132264 109813312
Foreign body sensation in eyes 260.62 22.76 189 643534 3145 109942431
Sinus operation 260.23 22.76 181 643542 2810 109942766
Heart rate decreased 260.01 22.76 79 643644 82677 109862899
Shock 257.69 22.76 13 643710 53575 109892001
Full blood count abnormal 256.19 22.76 18 643705 56034 109889542
Hypercalcaemia 250.77 22.76 4 643719 46653 109898923
Device defective 248.40 22.76 194 643529 3628 109941948
Urinary tract infection 247.63 22.76 1017 642706 325265 109620311
Ventricular tachycardia 247.45 22.76 10 643713 49999 109895577
Productive cough 247.24 22.76 1316 642407 112989 109832587
Burning sensation 246.09 22.76 924 642799 68288 109877288
Respiratory distress 244.84 22.76 51 643672 68823 109876753
Dry mouth 242.61 22.76 499 643224 199449 109746127
Arrhythmia 242.28 22.76 54 643669 69521 109876055
Gait inability 240.51 22.76 263 643460 136113 109809463
Anxiety 240.34 22.76 1111 642612 343967 109601609
Psychotic disorder 239.82 22.76 14 643709 50923 109894653
Pneumonitis 238.75 22.76 74 643649 76457 109869119
Pulmonary hypertension 237.84 22.76 23 643700 55197 109890379
Pancreatitis acute 237.57 22.76 34 643689 60240 109885336
Cerebral haemorrhage 237.46 22.76 45 643678 64923 109880653
Osteoporosis 237.03 22.76 105 643618 87047 109858529
Angina pectoris 234.51 22.76 40 643683 62255 109883321
Blood lactate dehydrogenase increased 233.39 22.76 5 643718 44329 109901247
Multiple sclerosis relapse 232.95 22.76 15 643708 50225 109895351
Abdominal distension 232.54 22.76 414 643309 174689 109770887
Hypophagia 231.81 22.76 20 643703 52606 109892970
Pregnancy 228.84 22.76 18 643705 51049 109894527
Drug dependence 228.80 22.76 16 643707 50004 109895572
Sciatica 227.66 22.76 127 643596 92272 109853304
Colitis ulcerative 227.06 22.76 83 643640 77280 109868296
Frequent bowel movements 224.56 22.76 68 643655 71322 109874254
Cerebral infarction 222.19 22.76 22 643701 51816 109893760
Toothache 220.54 22.76 449 643274 23126 109922450
Stevens-Johnson syndrome 220.48 22.76 13 643710 46888 109898688
Mood disorder due to a general medical condition 218.38 22.76 64 643659 71 109945505
Middle insomnia 216.66 22.76 411 643312 20091 109925485
Sinus tachycardia 216.49 22.76 10 643713 44483 109901093
Nasal polyps 216.27 22.76 322 643401 12878 109932698
Eosinophilic oesophagitis 215.44 22.76 119 643604 1193 109944383
Foot deformity 214.71 22.76 18 643705 48462 109897114
Hypervolaemia 214.62 22.76 20 643703 49440 109896136
Accidental overdose 214.51 22.76 25 643698 51809 109893767
Aggression 214.32 22.76 42 643681 59168 109886408
Cerebrovascular accident 211.09 22.76 463 643260 180821 109764755
Palpitations 210.00 22.76 378 643345 158834 109786742
Pneumocystis jirovecii pneumonia 209.93 22.76 9 643714 42726 109902850
Cholelithiasis 209.53 22.76 55 643668 63367 109882209
Clostridium difficile colitis 206.20 22.76 12 643711 43766 109901810
Acute myeloid leukaemia 205.96 22.76 3 643720 38107 109907469
Injection site nodule 203.59 22.76 188 643535 4458 109941118
Ejection fraction decreased 199.52 22.76 9 643714 40871 109904705
Paranasal sinus discomfort 199.01 22.76 215 643508 6190 109939386
Haemoptysis 198.78 22.76 83 643640 71271 109874305
White blood cell count increased 198.58 22.76 163 643560 96679 109848897
Dysphagia 198.35 22.76 1552 642171 152048 109793528
Palmar-plantar erythrodysaesthesia syndrome 197.11 22.76 10 643713 41015 109904561
Eosinophil count increased 196.92 22.76 401 643322 20657 109924919
Balance disorder 196.60 22.76 233 643490 116327 109829249
Subdural haematoma 196.45 22.76 3 643720 36451 109909125
Bacteraemia 195.52 22.76 13 643710 42377 109903199
Asthenopia 193.60 22.76 155 643568 3009 109942567
Memory impairment 193.45 22.76 549 643174 196395 109749181
Coagulopathy 193.35 22.76 11 643712 40900 109904676
Dandruff 192.90 22.76 83 643640 450 109945126
Cellulitis 192.84 22.76 271 643452 125745 109819831
Disease recurrence 192.82 22.76 57 643666 60727 109884849
Dyskinesia 191.54 22.76 34 643689 51412 109894164
Swelling 191.08 22.76 1227 642496 349814 109595762
Off label use 190.67 22.76 6983 636740 1493202 108452374
Periorbital inflammation 190.36 22.76 69 643654 214 109945362
Intentional self-injury 190.35 22.76 6 643717 37423 109908153
Muscle spasticity 189.26 22.76 4 643719 35911 109909665
Onychomadesis 189.03 22.76 22 643701 45641 109899935
General physical condition abnormal 188.73 22.76 227 643496 7363 109938213
Laboratory test abnormal 188.16 22.76 19 643704 44060 109901516
Diabetic ketoacidosis 187.97 22.76 15 643708 42043 109903533
Lower limb fracture 187.90 22.76 102 643621 75246 109870330
Autoimmune disorder 187.59 22.76 73 643650 65410 109880166
Eyelid pain 187.58 22.76 91 643632 678 109944898
Myelodysplastic syndrome 187.15 22.76 7 643716 37477 109908099
Haematoma 187.03 22.76 54 643669 58422 109887154
Hallucination, visual 186.10 22.76 11 643712 39594 109905982
Blood pressure diastolic decreased 185.25 22.76 5 643718 35880 109909696
Skin mass 185.10 22.76 256 643467 9560 109936016
Pallor 184.59 22.76 50 643673 56417 109889159
Diabetes mellitus 183.84 22.76 184 643539 99197 109846379
Respiration abnormal 183.74 22.76 255 643468 9554 109936022
Drug withdrawal syndrome 183.71 22.76 9 643714 38045 109907531
Facial discomfort 183.18 22.76 73 643650 314 109945262
Injection site discharge 182.74 22.76 111 643612 1349 109944227
Proteinuria 182.46 22.76 13 643710 40005 109905571
Posterior reversible encephalopathy syndrome 181.57 22.76 3 643720 33858 109911718
Fluid retention 180.96 22.76 169 643554 94138 109851438
Lip dry 180.93 22.76 189 643534 99894 109845682
Circulatory collapse 179.76 22.76 20 643703 42973 109902603
Device related infection 179.72 22.76 13 643710 39506 109906070
Tachypnoea 179.04 22.76 13 643710 39382 109906194
Exposure during pregnancy 178.59 22.76 448 643275 166976 109778600
Lupus-like syndrome 178.32 22.76 16 643707 40776 109904800
Hyperlipidaemia 177.93 22.76 7 643716 35841 109909735
Myoclonus 176.63 22.76 3 643720 32995 109912581
Aphasia 175.34 22.76 62 643661 58935 109886641
Exostosis 174.11 22.76 29 643694 45927 109899649
Lupus vulgaris 173.88 22.76 5 643718 33878 109911698
Drug effective for unapproved indication 173.82 22.76 303 643420 13864 109931712
Inappropriate antidiuretic hormone secretion 173.70 22.76 5 643718 33846 109911730
Hepatic steatosis 171.85 22.76 37 643686 48794 109896782
Finger deformity 169.39 22.76 5 643718 33087 109912489
Treatment noncompliance 169.02 22.76 108 643615 72882 109872694
Electrolyte imbalance 168.91 22.76 12 643711 37016 109908560
Metastases to liver 168.83 22.76 9 643714 35377 109910199
Retinitis 168.79 22.76 4 643719 32323 109913253
Miliaria 168.45 22.76 117 643606 1812 109943764
Rosacea 168.39 22.76 179 643544 5057 109940519
Ischaemic stroke 168.05 22.76 21 643702 41242 109904334
Mitral valve incompetence 167.17 22.76 6 643717 33323 109912253
Atelectasis 167.17 22.76 12 643711 36700 109908876
Lymphopenia 167.17 22.76 19 643704 40151 109905425
Gastrooesophageal reflux disease 167.13 22.76 515 643208 179461 109766115
Nail disorder 166.93 22.76 64 643659 57871 109887705
Superficial injury of eye 165.52 22.76 69 643654 341 109945235
Oropharyngeal discomfort 165.03 22.76 249 643474 10078 109935498
Injury associated with device 164.64 22.76 163 643560 4226 109941350
Status epilepticus 164.49 22.76 4 643719 31567 109914009
Basal cell carcinoma 164.08 22.76 32 643691 45238 109900338
Clostridium difficile infection 163.33 22.76 50 643673 52079 109893497
Intestinal obstruction 163.29 22.76 53 643670 53174 109892402
Device dislocation 161.53 22.76 5 643718 31699 109913877
Skin texture abnormal 161.09 22.76 74 643649 480 109945096
Spinal operation 160.55 22.76 254 643469 10718 109934858
Dysgeusia 160.09 22.76 105 643618 69880 109875696
Nasal polypectomy 160.00 22.76 44 643679 30 109945546
Coeliac disease 159.79 22.76 29 643694 43158 109902418
Peritonitis 159.73 22.76 7 643716 32600 109912976
Blood calcium decreased 159.59 22.76 13 643710 35832 109909744
Anaphylactic shock 158.71 22.76 51 643672 51495 109894081
Therapy partial responder 158.14 22.76 16 643707 37045 109908531
Hemiparesis 157.11 22.76 32 643691 43871 109901705
Metastases to bone 156.14 22.76 6 643717 31366 109914210
Ileus 156.01 22.76 5 643718 30724 109914852
Body temperature increased 155.07 22.76 62 643661 54651 109890925
Drainage 154.77 22.76 58 643665 203 109945373
Bronchopulmonary aspergillosis 154.76 22.76 4 643719 29859 109915717
Gait disturbance 154.65 22.76 966 642757 277242 109668334
Sunburn 154.33 22.76 160 643563 4388 109941188
Subarachnoid haemorrhage 153.85 22.76 4 643719 29698 109915878
Pharyngeal swelling 152.41 22.76 261 643462 11771 109933805
Body temperature decreased 152.38 22.76 18 643705 36917 109908659
Pericardial effusion 150.83 22.76 72 643651 57145 109888431
Pulmonary arterial hypertension 150.18 22.76 10 643713 32558 109913018
Maternal exposure during pregnancy 150.09 22.76 869 642854 254014 109691562
Injection site induration 149.59 22.76 251 643472 11132 109934444
Pustule 148.17 22.76 139 643584 3365 109942211
Iron deficiency anaemia 147.58 22.76 9 643714 31550 109914026
Polyneuropathy 147.11 22.76 10 643713 32002 109913574
Femur fracture 146.07 22.76 39 643684 44430 109901146
Adrenal insufficiency 145.39 22.76 34 643689 42356 109903220
Drug tolerance decreased 145.39 22.76 3 643720 27537 109918039
Adverse drug reaction 145.20 22.76 244 643479 105315 109840261
Poisoning 143.39 22.76 6 643717 29099 109916477
Obstructive airways disorder 143.27 22.76 45 643678 46104 109899472
Cytopenia 142.63 22.76 8 643715 30108 109915468
Ataxia 142.58 22.76 8 643715 30100 109915476
Hypoaesthesia 142.53 22.76 1157 642566 313066 109632510
Sensitivity to weather change 142.41 22.76 229 643494 9799 109935777
Blood albumin decreased 142.20 22.76 4 643719 27648 109917928
Full blood count decreased 141.92 22.76 12 643711 32087 109913489
Needle issue 141.77 22.76 318 643405 17522 109928054
Hand-foot-and-mouth disease 141.71 22.76 75 643648 685 109944891
Heart rate increased 140.45 22.76 402 643321 143432 109802144
Neutrophil count increased 140.23 22.76 18 643705 34634 109910942
Hypoalbuminaemia 139.40 22.76 7 643716 28967 109916609
Cystitis 139.34 22.76 108 643615 65928 109879648
Leukocytosis 138.46 22.76 70 643653 53758 109891818
Hypothermia 138.32 22.76 3 643720 26299 109919277
Thrombosis 137.94 22.76 264 643459 108398 109837178
Road traffic accident 137.15 22.76 260 643463 107138 109838438
Premature delivery 136.68 22.76 11 643712 30621 109914955
Cardiomyopathy 136.68 22.76 17 643706 33508 109912068
Osteonecrosis 135.41 22.76 18 643705 33723 109911853
Diabetes mellitus inadequate control 134.81 22.76 10 643713 29765 109915811
Myositis 133.90 22.76 13 643710 31103 109914473
Drug eruption 133.27 22.76 73 643650 53586 109891990
Myocardial ischaemia 133.16 22.76 5 643718 26679 109918897
Right ventricular failure 132.57 22.76 4 643719 25950 109919626
Skin warm 132.41 22.76 211 643512 8959 109936617
Small intestinal obstruction 132.15 22.76 16 643707 32197 109913379
Hallucination, auditory 131.54 22.76 5 643718 26392 109919184
Nephropathy toxic 131.06 22.76 7 643716 27471 109918105
Urinary incontinence 128.29 22.76 61 643662 48526 109897050
Rash papular 127.99 22.76 403 643320 27236 109918340
Arteriosclerosis coronary artery 127.83 22.76 4 643719 25114 109920462
Glomerular filtration rate decreased 127.55 22.76 11 643712 28945 109916631
Hypertransaminasaemia 126.65 22.76 3 643720 24252 109921324
Pigmentation disorder 126.51 22.76 183 643540 7128 109938448
Urosepsis 126.42 22.76 15 643708 30660 109914916
Brain oedema 126.22 22.76 16 643707 31082 109914494
Muscle spasms 125.31 22.76 1026 642697 277131 109668445
Skin erosion 124.65 22.76 162 643561 5692 109939884
Red blood cell sedimentation rate abnormal 124.38 22.76 4 643719 24505 109921071
Delusion 123.80 22.76 3 643720 23752 109921824
Chills 123.06 22.76 630 643093 189950 109755626
Restlessness 122.57 22.76 89 643634 56170 109889406
Abnormal behaviour 121.31 22.76 38 643685 39001 109906575
Poor venous access 121.00 22.76 5 643718 24517 109921059
Myopathy 120.18 22.76 6 643717 24954 109920622
Gastric disorder 120.01 22.76 24 643699 33333 109912243
Chapped lips 118.87 22.76 117 643606 3011 109942565
Haemodynamic instability 118.86 22.76 3 643720 22885 109922691
Dystonia 118.76 22.76 8 643715 25797 109919779
Left ventricular dysfunction 118.64 22.76 4 643719 23489 109922087
Anaphylactic reaction 117.91 22.76 311 643412 113989 109831587
Infection 117.76 22.76 1445 642278 360755 109584821
Tricuspid valve incompetence 117.35 22.76 5 643718 23868 109921708
Abdominal pain upper 117.24 22.76 1383 642340 347728 109597848
Periorbital pain 116.70 22.76 47 643676 209 109945367
Metastases to lung 116.21 22.76 4 643719 23059 109922517
Lip erythema 115.88 22.76 58 643665 466 109945110
Transient ischaemic attack 115.44 22.76 121 643602 63861 109881715
Cardiac failure acute 115.26 22.76 6 643717 24072 109921504
Aspergillus infection 114.86 22.76 9 643714 25607 109919969
Metastases to central nervous system 114.82 22.76 4 643719 22813 109922763
Injection site eczema 114.41 22.76 37 643686 71 109945505
Device operational issue 114.00 22.76 75 643648 1057 109944519
Gastroenteritis 113.22 22.76 42 643681 38758 109906818
Gastric ulcer 113.08 22.76 45 643678 39782 109905794
Pyelonephritis 112.85 22.76 9 643714 25241 109920335
Coordination abnormal 112.73 22.76 9 643714 25219 109920357
Exfoliative rash 112.43 22.76 136 643587 4438 109941138
Paranoia 112.32 22.76 4 643719 22370 109923206
Toxic skin eruption 112.06 22.76 14 643709 27501 109918075
Onychomycosis 111.95 22.76 42 643681 38489 109907087
Injection site hypoaesthesia 111.61 22.76 62 643661 629 109944947
Blood potassium increased 111.43 22.76 28 643695 33221 109912355
Emotional distress 111.40 22.76 61 643662 44786 109900790
Blood potassium decreased 111.04 22.76 91 643632 54023 109891553
Sudden death 111.00 22.76 8 643715 24387 109921189
Malnutrition 110.80 22.76 14 643709 27265 109918311
Disability 110.31 22.76 21 643702 30202 109915374
Withdrawal syndrome 109.97 22.76 24 643699 31356 109914220
Osteomyelitis 109.56 22.76 38 643685 36562 109909014
Cutaneous T-cell lymphoma 109.38 22.76 116 643607 3268 109942308
Cardiomegaly 108.99 22.76 19 643704 29111 109916465
Lethargy 108.89 22.76 239 643484 93337 109852239
Skin atrophy 108.80 22.76 161 643562 6403 109939173
Dysuria 108.57 22.76 114 643609 60117 109885459
Troponin increased 107.97 22.76 21 643702 29745 109915831
Atrial flutter 107.46 22.76 9 643714 24253 109921323
Adverse reaction 107.09 22.76 21 643702 29573 109916003
Acute coronary syndrome 106.85 22.76 7 643716 23105 109922471
Haemorrhoids 106.84 22.76 37 643686 35635 109909941
Oral candidiasis 106.72 22.76 64 643659 44696 109900880
Lack of administration site rotation 106.26 22.76 38 643685 112 109945464
Muscle rigidity 106.20 22.76 9 643714 24022 109921554
Transfusion 106.11 22.76 12 643711 25460 109920116
Abdominal pain lower 106.07 22.76 42 643681 37241 109908335
Nasal dryness 104.88 22.76 147 643576 5559 109940017
Skin depigmentation 104.80 22.76 75 643648 1221 109944355
Enterococcal infection 104.53 22.76 3 643720 20363 109925213
Haemolytic anaemia 104.12 22.76 4 643719 20916 109924660
Aspiration 103.71 22.76 25 643698 30508 109915068
Platelet count increased 103.44 22.76 15 643708 26319 109919257
Splenomegaly 103.43 22.76 11 643712 24487 109921089
Cholecystitis 103.41 22.76 14 643709 25868 109919708
Therapeutic product effect incomplete 103.32 22.76 820 642903 222985 109722591
Face oedema 103.25 22.76 33 643690 33436 109912140
Hydronephrosis 102.68 22.76 4 643719 20661 109924915
Dermatitis contact 102.36 22.76 241 643482 13712 109931864
Contusion 102.27 22.76 867 642856 232494 109713082
Sinus disorder 101.01 22.76 418 643305 32310 109913266
End stage renal disease 100.78 22.76 6 643717 21467 109924109
Eosinophilic granulomatosis with polyangiitis 100.52 22.76 204 643519 10482 109935094
Nasal operation 100.04 22.76 48 643675 348 109945228
Schizophrenia 99.77 22.76 7 643716 21819 109923757
Duodenal ulcer 99.70 22.76 3 643720 19511 109926065
Injection site scar 99.21 22.76 69 643654 1071 109944505
Ear infection 98.87 22.76 665 643058 62067 109883509
Joint dislocation 98.12 22.76 38 643685 34152 109911424
Vitreous floaters 97.61 22.76 184 643539 8950 109936626
Rales 97.38 22.76 14 643709 24725 109920851
Inflammation 97.28 22.76 691 643032 192547 109753029
Cardiac murmur 96.80 22.76 14 643709 24614 109920962
Allergy to animal 96.76 22.76 84 643639 1832 109943744
Hypogammaglobulinaemia 96.11 22.76 5 643718 20071 109925505
Mydriasis 96.02 22.76 9 643714 22148 109923428
Eosinophilic pneumonia 95.82 22.76 160 643563 7067 109938509
Blood test abnormal 95.78 22.76 24 643699 28530 109917046
Knee operation 95.17 22.76 157 643566 6865 109938711
Lipase increased 94.93 22.76 3 643720 18669 109926907
Nightmare 94.88 22.76 54 643669 38809 109906767
Oliguria 94.84 22.76 3 643720 18654 109926922
Cyanosis 94.13 22.76 28 643695 29713 109915863
Hyperthermia 93.92 22.76 8 643715 21264 109924312
Myocarditis 93.84 22.76 29 643694 30026 109915550
Mood altered 93.82 22.76 306 643417 21069 109924507
Skin necrosis 92.53 22.76 9 643714 21503 109924073
Hepatitis acute 92.01 22.76 4 643719 18762 109926814
Renal injury 91.72 22.76 4 643719 18709 109926867
Fear 91.59 22.76 13 643710 23180 109922396
Supraventricular tachycardia 91.22 22.76 16 643707 24406 109921170
Hypertensive crisis 90.96 22.76 16 643707 24356 109921220
Acute generalised exanthematous pustulosis 90.77 22.76 10 643713 21654 109923922
Scar 90.30 22.76 259 643464 16622 109928954
Disturbance in attention 90.25 22.76 138 643585 61857 109883719
Swelling face 90.02 22.76 877 642846 91444 109854132
Infusion site reaction 89.33 22.76 3 643720 17679 109927897
Benign prostatic hyperplasia 89.03 22.76 4 643719 18230 109927346
Motor dysfunction 88.98 22.76 17 643706 24389 109921187
Radiculopathy 88.97 22.76 6 643717 19330 109926246
Back injury 88.52 22.76 87 643636 47312 109898264
Dyshidrotic eczema 88.45 22.76 55 643668 699 109944877
Respiratory rate increased 88.27 22.76 19 643704 25064 109920512
Blood loss anaemia 87.86 22.76 4 643719 18021 109927555
Injection site indentation 87.78 22.76 40 643683 254 109945322
Speech disorder 87.77 22.76 139 643584 61430 109884146
Peripheral swelling 87.24 22.76 1742 641981 402292 109543284
Skin wound 87.08 22.76 83 643640 2051 109943525
Klebsiella infection 87.05 22.76 8 643715 20001 109925575
Eyelid thickening 86.49 22.76 28 643695 54 109945522
Presyncope 86.47 22.76 94 643629 48793 109896783
Taste disorder 86.40 22.76 155 643568 65232 109880344
Colitis ischaemic 86.32 22.76 4 643719 17746 109927830
Blood pressure diastolic increased 86.06 22.76 6 643717 18801 109926775
Visual acuity reduced 85.54 22.76 40 643683 32133 109913443
COVID-19 pneumonia 84.58 22.76 56 643667 37087 109908489
Ventricular extrasystoles 84.20 22.76 15 643708 22626 109922950
Peripheral sensory neuropathy 83.67 22.76 3 643720 16677 109928899
Ear discomfort 83.29 22.76 195 643528 11054 109934522
Drug tolerance 83.13 22.76 3 643720 16582 109928994
Infection parasitic 82.26 22.76 56 643667 838 109944738
Cholangitis 81.72 22.76 3 643720 16332 109929244
Hyperthyroidism 81.55 22.76 34 643689 29227 109916349
Eczema asteatotic 81.54 22.76 54 643669 770 109944806
Back pain 81.46 22.76 1595 642128 369401 109576175
Ocular surface disease 81.19 22.76 33 643690 151 109945425
Vaginal discharge 81.12 22.76 6 643717 17902 109927674
Spinal compression fracture 80.97 22.76 7 643716 18385 109927191
Anal incontinence 80.72 22.76 15 643708 21949 109923627
Hemiplegia 80.70 22.76 17 643706 22765 109922811
Nervous system disorder 80.47 22.76 42 643681 31679 109913897
Breath sounds abnormal 80.25 22.76 24 643699 25380 109920196
Epstein-Barr virus infection 80.18 22.76 8 643715 18730 109926846
Foetal death 80.09 22.76 3 643720 16042 109929534
Intestinal perforation 79.82 22.76 13 643710 20931 109924645
Vascular device infection 79.40 22.76 4 643719 16508 109929068
Hyperhidrosis 79.32 22.76 702 643021 186596 109758980
Mania 79.05 22.76 13 643710 20783 109924793
Molluscum contagiosum 78.97 22.76 48 643675 584 109944992
Increased viscosity of upper respiratory secretion 78.97 22.76 48 643675 584 109944992
Pharyngeal oedema 78.94 22.76 4 643719 16424 109929152
Immunodeficiency 78.83 22.76 66 643657 38772 109906804
Urine output decreased 78.82 22.76 11 643712 19865 109925711
Walking aid user 78.64 22.76 24 643699 25051 109920525
Respiratory syncytial virus infection 78.23 22.76 223 643500 14261 109931315
Renal disorder 78.10 22.76 104 643619 49375 109896201
Keratitis 77.93 22.76 121 643602 5023 109940553
Bronchiectasis 77.86 22.76 59 643664 36434 109909142
Ulcer haemorrhage 77.61 22.76 18 643705 22553 109923023
Joint effusion 77.42 22.76 14 643709 20891 109924685
Large intestine perforation 76.99 22.76 5 643718 16624 109928952
Hip arthroplasty 76.76 22.76 129 643594 55684 109889892
Blood triglycerides increased 76.68 22.76 22 643701 23904 109921672
Myasthenia gravis 76.30 22.76 16 643707 21495 109924081
Escherichia infection 76.14 22.76 22 643701 23794 109921782
Arteriosclerosis 75.37 22.76 25 643698 24742 109920834
Pneumothorax 75.34 22.76 57 643666 35228 109910348
Vaginal haemorrhage 75.11 22.76 26 643697 25048 109920528
Tenosynovitis 75.08 22.76 5 643718 16278 109929298
Pseudomonas infection 75.03 22.76 34 643689 27819 109917757
Appendicitis 74.74 22.76 36 643687 28428 109917148
Blood uric acid increased 74.37 22.76 17 643706 21512 109924064
Device dispensing error 74.23 22.76 33 643690 196 109945380
Skin hypertrophy 74.07 22.76 117 643606 4930 109940646
Swollen tongue 72.87 22.76 151 643572 60211 109885365
Enteritis 72.76 22.76 12 643711 19144 109926432
Neck pain 72.33 22.76 420 643303 122710 109822866
Affect lability 72.32 22.76 11 643712 18626 109926950
Osteopenia 71.96 22.76 20 643703 22189 109923387
Hepatomegaly 71.82 22.76 18 643705 21396 109924180
Spinal osteoarthritis 71.62 22.76 15 643708 20168 109925408
Blood calcium increased 71.50 22.76 10 643713 18030 109927546
Viral infection 71.37 22.76 542 643181 52597 109892979
Odynophagia 71.26 22.76 212 643511 13889 109931687
Dermatitis bullous 71.19 22.76 9 643714 17520 109928056
Encephalitis 71.12 22.76 12 643711 18827 109926749
Central nervous system lesion 71.06 22.76 5 643718 15548 109930028
Faeces discoloured 71.01 22.76 56 643667 33892 109911684
Flank pain 71.00 22.76 23 643700 23107 109922469
Staphylococcal sepsis 70.79 22.76 9 643714 17445 109928131
Sinusitis 70.60 22.76 2243 641480 294445 109651131
Nasal pruritus 70.56 22.76 52 643671 888 109944688
Musculoskeletal disorder 70.53 22.76 22 643701 22642 109922934
Pulmonary haemorrhage 70.48 22.76 7 643716 16449 109929127
Anhedonia 70.37 22.76 5 643718 15423 109930153
Sensory loss 70.13 22.76 19 643704 21438 109924138
Gangrene 69.86 22.76 7 643716 16334 109929242
Iron deficiency 69.24 22.76 12 643711 18464 109927112
Sinus headache 68.84 22.76 125 643598 5907 109939669
Pleuritic pain 68.78 22.76 7 643716 16133 109929443
Incorrect dose administered by product 68.46 22.76 33 643690 242 109945334
Product complaint 68.43 22.76 3 643720 13969 109931607
Keratoconus 68.35 22.76 29 643694 151 109945425
Diverticulum 68.11 22.76 6 643717 15520 109930056
Lung infiltration 68.02 22.76 29 643694 24599 109920977
Exposure via eye contact 67.84 22.76 17 643706 3 109945573
Cardiac failure chronic 67.53 22.76 3 643720 13808 109931768
Blood sodium decreased 67.42 22.76 74 643649 38245 109907331
Fracture 67.18 22.76 30 643693 24758 109920818
Hyperammonaemia 67.09 22.76 3 643720 13729 109931847
Fistula 66.87 22.76 6 643717 15293 109930283
Congestive cardiomyopathy 66.65 22.76 4 643719 14215 109931361
Hypotonia 66.65 22.76 7 643716 15738 109929838
Injection site hypersensitivity 66.57 22.76 77 643646 2394 109943182
Photophobia 66.51 22.76 312 643411 25459 109920117
Idiopathic urticaria 66.47 22.76 33 643690 260 109945316
Incorrect dose administered by device 66.38 22.76 132 643591 6682 109938894
Tardive dyskinesia 66.23 22.76 3 643720 13576 109932000
Neurological symptom 65.91 22.76 7 643716 15601 109929975
Throat clearing 65.75 22.76 102 643621 4231 109941345
Bone density decreased 65.73 22.76 8 643715 16034 109929542
Renal cyst 65.53 22.76 13 643710 18159 109927417
Product administration error 65.34 22.76 72 643651 37145 109908431
Complication associated with device 65.18 22.76 18 643705 20055 109925521
Diffuse large B-cell lymphoma 64.96 22.76 8 643715 15890 109929686
Faecaloma 64.75 22.76 6 643717 14902 109930674
Embolism 64.63 22.76 9 643714 16280 109929296
Mouth ulceration 64.61 22.76 113 643610 48025 109897551
Blood lactic acid increased 64.55 22.76 8 643715 15813 109929763
Chromaturia 64.54 22.76 46 643677 29314 109916262
Vasculitis 64.54 22.76 68 643655 35805 109909771
Enterobiasis 64.39 22.76 22 643701 54 109945522
Haemorrhagic stroke 64.27 22.76 4 643719 13785 109931791
Aphonia 63.72 22.76 192 643531 12668 109932908
Shoulder operation 63.69 22.76 89 643634 3356 109942220
Facial paralysis 63.01 22.76 31 643692 24183 109921393
Skin wrinkling 62.60 22.76 60 643663 1493 109944083
Seborrhoeic dermatitis 62.52 22.76 78 643645 2629 109942947
Menstruation delayed 62.48 22.76 64 643659 1730 109943846
Product administered to patient of inappropriate age 62.47 22.76 142 643581 7894 109937682
Staphylococcal bacteraemia 62.18 22.76 11 643712 16677 109928899
Eye operation 61.84 22.76 77 643646 2590 109942986
Generalised oedema 61.31 22.76 53 643670 30651 109914925
Ecchymosis 61.29 22.76 13 643710 17325 109928251
Panniculitis 60.91 22.76 9 643714 15573 109930003
Forced expiratory volume decreased 60.89 22.76 4 643719 13172 109932404
Bladder cancer 60.85 22.76 21 643702 20271 109925305
Large intestine polyp 60.82 22.76 8 643715 15109 109930467
Mental impairment 60.42 22.76 28 643695 22611 109922965
Aortic stenosis 60.24 22.76 4 643719 13055 109932521
Failure to thrive 60.22 22.76 5 643718 13569 109932007
Bone disorder 60.08 22.76 24 643699 21168 109924408
Tinnitus 59.97 22.76 168 643555 60372 109885204
Ulcer 59.90 22.76 99 643624 43017 109902559
Decubitus ulcer 59.88 22.76 16 643707 18220 109927356
Heart rate irregular 59.41 22.76 67 643656 34207 109911369
Temperature regulation disorder 58.96 22.76 4 643719 12822 109932754
Skin tightness 58.66 22.76 112 643611 5501 109940075
Coronary artery stenosis 58.54 22.76 6 643717 13752 109931824
Electrocardiogram abnormal 58.51 22.76 18 643705 18691 109926885
Gastric haemorrhage 58.21 22.76 11 643712 15904 109929672
Mixed liver injury 57.85 22.76 3 643720 12076 109933500
Foreign body in eye 57.21 22.76 33 643690 362 109945214
Candida infection 57.19 22.76 121 643602 47888 109897688
Bronchospasm 57.05 22.76 55 643668 30184 109915392
Haemorrhage 56.91 22.76 375 643348 106317 109839259
Rebound nasal congestion 56.67 22.76 19 643704 43 109945533
Skin hypopigmentation 56.50 22.76 55 643668 1396 109944180
Cardiovascular disorder 56.46 22.76 31 643692 22729 109922847
Seasonal allergy 56.30 22.76 246 643477 19476 109926100
Blood magnesium decreased 56.11 22.76 23 643700 19973 109925603
Bundle branch block right 56.01 22.76 4 643719 12287 109933289
Vitamin D deficiency 55.98 22.76 19 643704 18533 109927043
Ileus paralytic 55.95 22.76 3 643720 11734 109933842
Bradyphrenia 55.90 22.76 3 643720 11725 109933851
Eczema herpeticum 55.87 22.76 35 643688 451 109945125
Chest discomfort 55.86 22.76 1366 642357 172482 109773094
Apathy 55.74 22.76 13 643710 16226 109929350
Proctalgia 55.66 22.76 6 643717 13216 109932360
Laryngitis 55.62 22.76 101 643622 42310 109903266
Prostate cancer 55.55 22.76 83 643640 37558 109908018
Acarodermatitis 55.51 22.76 63 643660 1918 109943658
Potentiating drug interaction 55.42 22.76 3 643720 11640 109933936
Dark circles under eyes 55.11 22.76 36 643687 501 109945075
Blood creatine increased 54.74 22.76 3 643720 11518 109934058
Nasal inflammation 54.40 22.76 46 643677 967 109944609
Arthropod bite 54.29 22.76 151 643572 9520 109936056
Infusion site pain 54.04 22.76 17 643706 17402 109928174
Bundle branch block left 53.87 22.76 6 643717 12882 109932694
Polyuria 53.81 22.76 18 643705 17720 109927856
Lip exfoliation 53.77 22.76 41 643682 739 109944837
Respiratory disorder 53.76 22.76 223 643500 71159 109874417
Serum ferritin increased 53.57 22.76 4 643719 11843 109933733
Hiatus hernia 53.51 22.76 49 643674 27557 109918019
Injection site injury 52.95 22.76 47 643676 1057 109944519
Anal abscess 52.43 22.76 4 643719 11634 109933942
Infusion site extravasation 52.41 22.76 4 643719 11630 109933946
Infective pulmonary exacerbation of cystic fibrosis 52.37 22.76 11 643712 14760 109930816
Injection site paraesthesia 52.13 22.76 40 643683 728 109944848
Pathological fracture 51.84 22.76 5 643718 12027 109933549
Aortic arteriosclerosis 51.51 22.76 3 643720 10935 109934641
Monocyte count increased 51.23 22.76 8 643715 13285 109932291
Skin lesion 51.08 22.76 492 643231 51139 109894437
Left ventricular hypertrophy 50.97 22.76 8 643715 13236 109932340
Pustular psoriasis 50.62 22.76 9 643714 13596 109931980
Eczema infected 50.60 22.76 24 643699 169 109945407
Post procedural haemorrhage 50.20 22.76 14 643709 15498 109930078
Cushingoid 50.11 22.76 5 643718 11707 109933869
Bacterial infection 49.99 22.76 122 643601 45914 109899662
Brain injury 49.96 22.76 9 643714 13467 109932109
Breast cancer metastatic 49.93 22.76 4 643719 11177 109934399
Nephropathy 49.91 22.76 9 643714 13458 109932118
Conjunctival papillae 49.83 22.76 12 643711 0 109945576
Metastases to lymph nodes 49.72 22.76 13 643710 15019 109930557
Breast cancer 49.47 22.76 93 643630 38449 109907127
Endocarditis 49.42 22.76 9 643714 13362 109932214
Arterial occlusive disease 49.20 22.76 14 643709 15294 109930282
Therapeutic response delayed 49.16 22.76 50 643673 1340 109944236
Skin hyperpigmentation 49.04 22.76 136 643587 8560 109937016
Ocular rosacea 49.01 22.76 14 643709 13 109945563
Adenovirus infection 48.91 22.76 4 643719 10990 109934586
Maternal exposure timing unspecified 48.77 22.76 31 643692 20982 109924594
Bacterial sepsis 48.67 22.76 3 643720 10423 109935153
Eczema weeping 48.47 22.76 15 643708 23 109945553
Protein total decreased 48.34 22.76 4 643719 10886 109934690
Tinea infection 48.08 22.76 51 643672 1437 109944139
Chronic sinusitis 48.05 22.76 45 643678 25039 109920537
Squamous cell carcinoma of skin 47.93 22.76 20 643703 17183 109928393
Hepatitis C 47.48 22.76 8 643715 12565 109933011
Colitis microscopic 47.43 22.76 10 643713 13384 109932192
Choking 47.43 22.76 194 643529 14916 109930660
Blepharospasm 47.39 22.76 162 643561 54689 109890887
Sinonasal obstruction 47.22 22.76 29 643694 360 109945216
Nystagmus 46.88 22.76 6 643717 11571 109934005
Parosmia 46.87 22.76 176 643547 13004 109932572
Dementia 46.59 22.76 70 643653 31603 109913973
Body height decreased 46.56 22.76 4 643719 10559 109935017
Pneumonia fungal 46.49 22.76 14 643709 14740 109930836
Emotional disorder 46.46 22.76 202 643521 15958 109929618
Protein urine present 46.39 22.76 6 643717 11478 109934098
Migraine 46.31 22.76 711 643012 170941 109774635
Skin discharge 46.26 22.76 22 643701 156 109945420
Coronary artery occlusion 46.14 22.76 17 643706 15755 109929821
Eczema nummular 46.14 22.76 30 643693 414 109945162
Affective disorder 45.85 22.76 157 643566 11084 109934492
Spinal stenosis 45.78 22.76 27 643696 19029 109926547
Vitiligo 45.75 22.76 71 643652 2946 109942630
Weight fluctuation 45.73 22.76 37 643686 22108 109923468
Cheilitis 45.67 22.76 109 643614 6256 109939320
Intentional product misuse 45.65 22.76 1054 642669 131850 109813726
Injection site coldness 45.52 22.76 20 643703 115 109945461
Dissociation 45.44 22.76 3 643720 9839 109935737
Cutaneous T-cell lymphoma stage IV 45.28 22.76 16 643707 45 109945531
Inflammatory marker increased 45.10 22.76 14 643709 14455 109931121
Discharge 45.01 22.76 60 643663 2162 109943414
Pneumonia bacterial 44.80 22.76 52 643671 26209 109919367
Atopic keratoconjunctivitis 44.72 22.76 15 643708 34 109945542
Escherichia bacteraemia 44.39 22.76 4 643719 10160 109935416
Deformity 44.37 22.76 4 643719 10156 109935420
Seronegative arthritis 44.34 22.76 11 643712 13166 109932410
Deafness neurosensory 44.21 22.76 3 643720 9616 109935960
Micturition urgency 44.16 22.76 29 643694 19291 109926285
Polyarthritis 43.98 22.76 28 643695 18935 109926641
Ketoacidosis 43.97 22.76 4 643719 10083 109935493
Blood thyroid stimulating hormone increased 43.94 22.76 9 643714 12292 109933284
Orthopnoea 43.94 22.76 6 643717 11015 109934561
Erythema multiforme 43.88 22.76 35 643688 21062 109924514
Incontinence 43.74 22.76 21 643702 16614 109928962
Metabolic disorder 43.66 22.76 5 643718 10505 109935071
Left ventricular failure 43.56 22.76 7 643716 11382 109934194
Hyperreflexia 43.48 22.76 3 643720 9482 109936094
Systemic candida 43.36 22.76 4 643719 9970 109935606
Thrombocytosis 43.31 22.76 5 643718 10439 109935137
Arthritis 43.25 22.76 700 643023 166886 109778690
Demyelination 43.17 22.76 3 643720 9426 109936150
Hydrocephalus 42.94 22.76 5 643718 10370 109935206
Fungal skin infection 42.50 22.76 115 643608 7134 109938442
Organising pneumonia 42.27 22.76 15 643708 14228 109931348
Lung neoplasm malignant 42.26 22.76 83 643640 33759 109911817
Carotid artery stenosis 42.25 22.76 3 643720 9260 109936316
Mouth haemorrhage 42.14 22.76 13 643710 13475 109932101
Pelvic pain 42.11 22.76 20 643703 15922 109929654
Systemic inflammatory response syndrome 41.79 22.76 12 643711 13031 109932545
Psychomotor hyperactivity 41.72 22.76 34 643689 20243 109925333
Pain in jaw 41.65 22.76 155 643568 51022 109894554
Tuberculosis 41.56 22.76 26 643697 17748 109927828
Intervertebral disc degeneration 41.54 22.76 27 643696 18058 109927518
Wrong product administered 41.33 22.76 7 643716 10953 109934623
Menstruation irregular 41.30 22.76 99 643624 5698 109939878
Alopecia 41.30 22.76 1719 642004 363034 109582542
Partial seizures 41.17 22.76 8 643715 11341 109934235
Eyelid infection 41.13 22.76 27 643696 379 109945197
Diverticulum intestinal 40.99 22.76 9 643714 11710 109933866
Lung adenocarcinoma 40.96 22.76 4 643719 9527 109936049
Oesophagitis 40.76 22.76 65 643658 28650 109916926
Diarrhoea haemorrhagic 40.73 22.76 20 643703 15619 109929957
Arthritis bacterial 40.61 22.76 7 643716 10813 109934763
Paralysis 40.55 22.76 20 643703 15580 109929996
Lip pruritus 40.42 22.76 44 643679 1278 109944298
Milk allergy 40.35 22.76 24 643699 280 109945296
Wisdom teeth removal 40.33 22.76 35 643688 763 109944813
Mass 40.28 22.76 33 643690 19597 109925979
Abscess 40.12 22.76 61 643662 27408 109918168
Oesophageal candidiasis 40.06 22.76 9 643714 11525 109934051
Gluten sensitivity 39.91 22.76 29 643694 484 109945092
Tooth disorder 39.85 22.76 69 643654 29440 109916136
Non-cardiac chest pain 39.61 22.76 6 643717 10192 109935384
Multiple sclerosis 39.56 22.76 55 643668 25643 109919933
Nocturia 39.52 22.76 25 643698 16965 109928611
Necrosis 39.41 22.76 9 643714 11397 109934179
Personality change 39.40 22.76 8 643715 10994 109934582
Mental status changes 39.37 22.76 270 643453 75852 109869724
Blood urine present 39.25 22.76 50 643673 24195 109921381
Ankylosing spondylitis 39.12 22.76 21 643702 15591 109929985
Immune thrombocytopenia 38.96 22.76 44 643679 22450 109923126
Blood creatinine decreased 38.84 22.76 4 643719 9133 109936443
Product administration interrupted 38.84 22.76 9 643714 11283 109934293
Alcohol intolerance 38.77 22.76 27 643696 420 109945156
Blood chloride decreased 38.72 22.76 4 643719 9111 109936465
Dry throat 38.54 22.76 130 643593 9108 109936468
Intercepted product dispensing error 38.49 22.76 21 643702 205 109945371
Device breakage 38.37 22.76 16 643707 13753 109931823
Sinus node dysfunction 38.35 22.76 4 643719 9043 109936533
Drug ineffective for unapproved indication 38.29 22.76 825 642898 102013 109843563
Wheezing 38.28 22.76 1835 641888 253395 109692181
Hypereosinophilic syndrome 38.28 22.76 35 643688 819 109944757
Sexual dysfunction 38.23 22.76 3 643720 8527 109937049
Hypercapnia 38.17 22.76 9 643714 11150 109934426
Venous thrombosis 38.10 22.76 3 643720 8502 109937074
Anal fissure 37.96 22.76 6 643717 9875 109935701
Dialysis 37.81 22.76 35 643688 19584 109925992
Sinus congestion 37.77 22.76 305 643418 30154 109915422
Systemic infection 37.63 22.76 6 643717 9813 109935763
Asthma exercise induced 37.56 22.76 21 643702 216 109945360
Major depression 37.47 22.76 8 643715 10613 109934963
Gastric cancer 37.41 22.76 9 643714 10999 109934577
Asphyxia 37.29 22.76 18 643705 14197 109931379
Gastroenteritis viral 37.28 22.76 310 643413 30916 109914660
Cerebral ischaemia 37.22 22.76 12 643711 12092 109933484
Oesophageal discomfort 37.18 22.76 28 643695 495 109945081
Mean cell volume increased 37.14 22.76 3 643720 8327 109937249
Hyperaesthesia teeth 37.12 22.76 56 643667 2266 109943310
Hyperlactacidaemia 36.90 22.76 3 643720 8283 109937293
Postoperative wound infection 36.89 22.76 23 643700 15730 109929846
Diverticulitis 36.79 22.76 173 643550 53349 109892227
Abnormal sensation in eye 36.78 22.76 54 643669 2132 109943444
Ammonia increased 36.70 22.76 3 643720 8247 109937329
Skin ulcer 36.65 22.76 547 643176 63098 109882478
Pulmonary tuberculosis 36.38 22.76 5 643718 9134 109936442
Post procedural complication 36.30 22.76 62 643661 26596 109918980
Pre-eclampsia 36.22 22.76 4 643719 8646 109936930
Ischaemia 36.08 22.76 5 643718 9078 109936498
Pollakiuria 35.87 22.76 134 643589 44061 109901515
Eye symptom 35.86 22.76 19 643704 174 109945402
Sticky skin 35.84 22.76 12 643711 27 109945549
Hiccups 35.79 22.76 15 643708 12854 109932722
Conjunctivitis allergic 35.78 22.76 105 643618 6826 109938750
Prostatic specific antigen increased 35.74 22.76 14 643709 12497 109933079
Eye ulcer 35.72 22.76 24 643699 351 109945225
Hyperpyrexia 35.72 22.76 3 643720 8066 109937510
Fibrin D dimer increased 35.59 22.76 7 643716 9838 109935738
Enthesopathy 35.59 22.76 14 643709 12464 109933112
Throat irritation 35.56 22.76 472 643251 53080 109892496
Autoimmune hepatitis 35.53 22.76 21 643702 14783 109930793
Menstrual disorder 35.50 22.76 83 643640 4701 109940875
Laryngeal oedema 35.40 22.76 7 643716 9800 109935776
Renal function test abnormal 35.36 22.76 5 643718 8941 109936635
Circumoral swelling 35.35 22.76 14 643709 59 109945517
Dermatitis exfoliative 35.33 22.76 11 643712 11336 109934240
Periorbital disorder 34.99 22.76 14 643709 61 109945515
Procedural complication 34.91 22.76 4 643719 8401 109937175
Peripheral arterial occlusive disease 34.83 22.76 6 643717 9274 109936302
Abdominal abscess 34.69 22.76 5 643718 8814 109936762
Dacryostenosis acquired 34.57 22.76 30 643693 654 109944922
Head injury 34.54 22.76 131 643592 42886 109902690
Musculoskeletal discomfort 34.41 22.76 245 643478 23293 109922283
Hepatitis B 34.40 22.76 7 643716 9605 109935971
Metastasis 34.17 22.76 4 643719 8263 109937313
Exposure to extreme temperature 34.17 22.76 10 643713 11 109945565
Carotid artery occlusion 34.16 22.76 7 643716 9558 109936018
Tongue oedema 34.11 22.76 4 643719 8252 109937324
Loss of personal independence in daily activities 34.05 22.76 1128 642595 148892 109796684
Inappropriate schedule of product discontinuation 34.04 22.76 15 643708 87 109945489
Colorectal cancer 33.98 22.76 6 643717 9108 109936468
Croup infectious 33.95 22.76 36 643687 1014 109944562
Atrioventricular block 33.86 22.76 29 643694 16848 109928728
Allergy to metals 33.78 22.76 31 643692 729 109944847
Decreased activity 33.74 22.76 140 643583 10834 109934742
Blood glucose decreased 33.74 22.76 76 643647 29412 109916164
Furuncle 33.57 22.76 119 643604 8549 109937027
Blood phosphorus decreased 33.52 22.76 3 643720 7662 109937914
Tongue disorder 33.31 22.76 21 643702 14277 109931299
Peptic ulcer 33.27 22.76 3 643720 7616 109937960
Paraesthesia 33.26 22.76 1294 642429 275227 109670349
Haemorrhoidal haemorrhage 33.25 22.76 4 643719 8089 109937487
Supraventricular extrasystoles 33.14 22.76 4 643719 8069 109937507
Skin indentation 33.08 22.76 11 643712 24 109945552
Chest X-ray abnormal 32.95 22.76 5 643718 8482 109937094
Herpes ophthalmic 32.79 22.76 47 643676 1815 109943761
Oesophageal carcinoma 32.75 22.76 13 643710 11511 109934065
Diplopia 32.73 22.76 129 643594 41765 109903811
Hepatic cancer 32.68 22.76 12 643711 11144 109934432
Foetal exposure during pregnancy 32.65 22.76 3 643720 7502 109938074
Bacterial test positive 32.63 22.76 4 643719 7973 109937603
Humerus fracture 32.58 22.76 11 643712 10765 109934811
Skin plaque 32.56 22.76 153 643570 12492 109933084
Salivary hypersecretion 32.50 22.76 32 643691 17389 109928187
Gastrointestinal perforation 32.39 22.76 3 643720 7453 109938123
Neck surgery 32.35 22.76 50 643673 2067 109943509
Pulmonary mass 32.33 22.76 110 643613 37191 109908385
Pain 32.26 22.76 4973 638750 949982 108995594
Oral mucosal eruption 32.25 22.76 37 643686 1140 109944436
Product availability issue 32.17 22.76 4 643719 7886 109937690
Defaecation urgency 32.09 22.76 6 643717 8741 109936835
Haemoglobin increased 32.04 22.76 7 643716 9140 109936436
Quality of life decreased 31.90 22.76 165 643558 14004 109931572
Gynaecomastia 31.78 22.76 8 643715 9482 109936094
Pancreatic carcinoma 31.78 22.76 24 643699 14848 109930728
Intestinal haemorrhage 31.76 22.76 3 643720 7338 109938238
Thinking abnormal 31.63 22.76 25 643698 15115 109930461
Dysstasia 31.60 22.76 93 643630 32893 109912683
Infusion site erythema 31.59 22.76 15 643708 11944 109933632
Seborrhoea 31.58 22.76 26 643697 526 109945050
Burns second degree 31.33 22.76 4 643719 7729 109937847
Sleep apnoea syndrome 31.31 22.76 125 643598 40322 109905254
Hepatic enzyme abnormal 31.25 22.76 9 643714 9754 109935822
Peripheral vascular disorder 31.21 22.76 6 643717 8570 109937006
Limb operation 31.16 22.76 71 643652 3953 109941623
Gingival bleeding 31.00 22.76 42 643681 19797 109925779
Sweating fever 30.97 22.76 14 643709 87 109945489
Bradykinesia 30.94 22.76 12 643711 10776 109934800
Vitamin B12 deficiency 30.86 22.76 10 643713 10045 109935531
B-cell lymphoma 30.75 22.76 3 643720 7151 109938425
Guillain-Barre syndrome 30.73 22.76 12 643711 10732 109934844
Helminthic infection 30.71 22.76 14 643709 89 109945487
Exposure to fungus 30.71 22.76 18 643705 204 109945372
Steroid dependence 30.66 22.76 6 643717 8463 109937113
Neutrophilia 30.44 22.76 11 643712 10318 109935258
Hot flush 30.43 22.76 242 643481 65794 109879782
Bone lesion 30.39 22.76 3 643720 7084 109938492
Gout 30.24 22.76 110 643613 36456 109909120
Portal vein thrombosis 30.23 22.76 3 643720 7055 109938521
Muscle atrophy 30.15 22.76 20 643703 13234 109932342
Haemorrhagic diathesis 30.14 22.76 4 643719 7504 109938072
Aortic aneurysm 30.13 22.76 10 643713 9894 109935682
Dermatitis psoriasiform 30.13 22.76 66 643657 3578 109941998
Dyspnoea at rest 30.03 22.76 6 643717 8340 109937236
Polymenorrhoea 29.74 22.76 35 643688 1109 109944467
Erysipelas 29.74 22.76 20 643703 13138 109932438
Paradoxical drug reaction 29.72 22.76 10 643713 9807 109935769
Blindness 29.66 22.76 110 643613 36249 109909327
Norovirus infection 29.65 22.76 51 643672 2308 109943268
Deafness 29.62 22.76 70 643653 26639 109918937
Ageusia 29.61 22.76 206 643517 19439 109926137
Haemoglobin abnormal 29.54 22.76 8 643715 9030 109936546
Crepitations 29.54 22.76 13 643710 10822 109934754
Gestational diabetes 29.51 22.76 4 643719 7385 109938191
Pneumonia viral 29.46 22.76 14 643709 11143 109934433
Joint injury 29.46 22.76 126 643597 39868 109905708
Neurological decompensation 29.29 22.76 3 643720 6880 109938696
Synovial cyst 29.19 22.76 15 643708 11415 109934161
Oligomenorrhoea 29.16 22.76 31 643692 876 109944700
Milia 29.12 22.76 14 643709 102 109945474
Product administered by wrong person 29.12 22.76 14 643709 102 109945474
Paronychia 29.12 22.76 14 643709 11067 109934509
Impetigo 29.03 22.76 53 643670 2515 109943061
Product temperature excursion issue 28.99 22.76 30 643693 821 109944755
Erythrodermic atopic dermatitis 28.86 22.76 10 643713 26 109945550
Blood thyroid stimulating hormone decreased 28.72 22.76 4 643719 7235 109938341
Brain abscess 28.70 22.76 3 643720 6771 109938805
Paranasal sinus hypersecretion 28.67 22.76 75 643648 4559 109941017
Urinary tract infection bacterial 28.61 22.76 6 643717 8061 109937515
Blood pressure inadequately controlled 28.51 22.76 5 643718 7628 109937948
Euphoric mood 28.50 22.76 8 643715 8819 109936757
Bicytopenia 28.44 22.76 3 643720 6721 109938855
Bronchopulmonary aspergillosis allergic 28.42 22.76 7 643716 8419 109937157
Vertigo 28.40 22.76 346 643377 86524 109859052
Antinuclear antibody positive 28.35 22.76 9 643714 9159 109936417
Lip oedema 28.34 22.76 5 643718 7595 109937981
Ischaemic cardiomyopathy 28.33 22.76 6 643717 8005 109937571
Infusion site swelling 28.30 22.76 11 643712 9866 109935710
Skin odour abnormal 28.19 22.76 51 643672 2403 109943173
Spinal pain 28.13 22.76 40 643683 18475 109927101
Lichenification 28.12 22.76 32 643691 977 109944599
Spinal cord compression 28.09 22.76 5 643718 7547 109938029
Cutaneous vasculitis 27.90 22.76 20 643703 12709 109932867
Renal cancer 27.90 22.76 21 643702 13013 109932563
Spinal fracture 27.84 22.76 56 643667 22577 109922999
Gastric ulcer haemorrhage 27.70 22.76 12 643711 10082 109935494
Actinic keratosis 27.53 22.76 4 643719 7009 109938567
Pre-existing condition improved 27.37 22.76 3 643720 6523 109939053
Drug dose omission by device 27.30 22.76 161 643562 14355 109931221
Breast cancer stage I 27.24 22.76 5 643718 7382 109938194
Movement disorder 27.24 22.76 114 643609 36290 109909286
Stress at work 27.18 22.76 36 643687 1289 109944287
Staphylococcus test positive 27.15 22.76 5 643718 7365 109938211
Lymphocytic infiltration 27.07 22.76 45 643678 1980 109943596
Normocytic anaemia 27.06 22.76 3 643720 6464 109939112
Hepatosplenomegaly 27.04 22.76 4 643719 6915 109938661
Squamous cell carcinoma 26.96 22.76 41 643682 18422 109927154
Hepatic lesion 26.87 22.76 8 643715 8485 109937091
Malabsorption 26.83 22.76 3 643720 6422 109939154
Abdominal tenderness 26.75 22.76 20 643703 12437 109933139
Sickle cell anaemia with crisis 26.75 22.76 11 643712 9534 109936042
Formication 26.74 22.76 83 643640 5565 109940011
Meningitis aseptic 26.66 22.76 12 643711 9858 109935718
Periorbital oedema 26.59 22.76 13 643710 10179 109935397
Gallbladder operation 26.56 22.76 49 643674 2344 109943232
Genital haemorrhage 26.55 22.76 5 643718 7247 109938329
Phlebitis 26.53 22.76 12 643711 9829 109935747
Colon cancer 26.53 22.76 34 643689 16409 109929167
Depressive symptom 26.48 22.76 8 643715 8406 109937170
Cardiac operation 26.47 22.76 86 643637 5909 109939667
Lumbar vertebral fracture 26.45 22.76 10 643713 9121 109936455
Cardiac disorder 26.41 22.76 300 643423 75980 109869596
Immunosuppression 26.36 22.76 39 643684 17720 109927856
Eye colour change 26.33 22.76 23 643700 506 109945070
Feeling cold 26.33 22.76 105 643618 33882 109911694
Eyelid cyst 26.28 22.76 15 643708 161 109945415
Abdominal operation 26.26 22.76 29 643694 856 109944720
Incoherent 26.21 22.76 8 643715 8350 109937226
Oesophageal ulcer 26.13 22.76 7 643716 7957 109937619
Ankle operation 25.91 22.76 36 643687 1350 109944226
Epigastric discomfort 25.90 22.76 10 643713 9005 109936571
Product dispensing issue 25.86 22.76 25 643698 629 109944947
Psoriasis 25.75 22.76 1028 642695 138965 109806611
Nocardiosis 25.68 22.76 6 643717 7480 109938096
Tonsillolith 25.57 22.76 8 643715 13 109945563
Dental caries 25.56 22.76 22 643701 12751 109932825
Essential hypertension 25.55 22.76 7 643716 7840 109937736
Product used for unknown indication 25.41 22.76 43 643680 1920 109943656
Nasal discharge discolouration 25.37 22.76 57 643666 3144 109942432
Eczema infantile 25.32 22.76 7 643716 5 109945571
Localised oedema 25.25 22.76 11 643712 9212 109936364
Diabetes insipidus 25.21 22.76 4 643719 6566 109939010
N-terminal prohormone brain natriuretic peptide increased 25.21 22.76 3 643720 6118 109939458
Intervertebral discitis 25.21 22.76 5 643718 6985 109938591
Emphysema 25.06 22.76 48 643675 19708 109925868
Liver abscess 25.02 22.76 7 643716 7732 109937844
Catarrh 24.92 22.76 6 643717 7329 109938247
Epistaxis 24.92 22.76 573 643150 129799 109815777
Nail cuticle fissure 24.91 22.76 6 643717 0 109945576
Swollen tear duct 24.81 22.76 9 643714 28 109945548
Rhinalgia 24.73 22.76 64 643659 3865 109941711
Stridor 24.72 22.76 5 643718 6890 109938686
Restless legs syndrome 24.64 22.76 68 643655 24558 109921018
Madarosis 24.52 22.76 59 643664 3404 109942172
Facial pain 24.40 22.76 163 643560 15176 109930400
Low density lipoprotein increased 24.39 22.76 16 643707 10650 109934926
Lymphoproliferative disorder 24.34 22.76 6 643717 7212 109938364
Injection site pustule 24.34 22.76 12 643711 93 109945483
Device failure 24.28 22.76 6 643717 7201 109938375
Therapy change 24.25 22.76 14 643709 9983 109935593
Hyperaesthesia 24.23 22.76 30 643693 14697 109930879
Impaired work ability 24.22 22.76 76 643647 26343 109919233
Pelvic fracture 24.17 22.76 28 643695 14126 109931450
Therapy interrupted 24.17 22.76 180 643543 49642 109895934
Dyspnoea exertional 24.15 22.76 443 643280 103617 109841959
Ear swelling 24.04 22.76 44 643679 2092 109943484
Asthma-chronic obstructive pulmonary disease overlap syndrome 24.04 22.76 4 643719 6340 109939236
Pemphigoid 24.04 22.76 49 643674 19658 109925918
Uveitis 23.99 22.76 57 643666 21653 109923923
Renal cell carcinoma 23.99 22.76 7 643716 7523 109938053
Lip blister 23.92 22.76 57 643666 3268 109942308
SARS-CoV-1 test positive 23.89 22.76 8 643715 18 109945558
Intracranial pressure increased 23.83 22.76 16 643707 10519 109935057
Faecal calprotectin increased 23.83 22.76 5 643718 6714 109938862
Total lung capacity decreased 23.82 22.76 6 643717 7108 109938468
Skin papilloma 23.62 22.76 91 643632 6805 109938771
Allergy to arthropod sting 23.44 22.76 18 643705 328 109945248
Hepatic cyst 23.43 22.76 8 643715 7775 109937801
Arthritis infective 23.37 22.76 16 643707 10413 109935163
Acute lymphocytic leukaemia 23.31 22.76 3 643720 5762 109939814
Alopecia areata 23.30 22.76 44 643679 2143 109943433
Thirst 23.20 22.76 58 643665 21649 109923927
Eosinophilic pneumonia chronic 23.04 22.76 22 643701 545 109945031
Pulmonary vasculitis 23.02 22.76 5 643718 6555 109939021
Mean cell haemoglobin concentration decreased 22.87 22.76 3 643720 5679 109939897
Petechiae 22.87 22.76 65 643658 23252 109922324
Facial paresis 22.84 22.76 4 643719 6109 109939467
White blood cell count abnormal 22.80 22.76 6 643717 6903 109938673
Meningioma 22.78 22.76 3 643720 5662 109939914

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AH05 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Agents for dermatitis, excluding corticosteroids
FDA CS M0001357 Antibodies, Monoclonal
FDA MoA N0000193341 Interleukin 4 Receptor alpha Antagonists
FDA EPC N0000193342 Interleukin-4 Receptor alpha Antagonist
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

D11AH Agents for dermatitis, excluding corticosteroids 11 drugs
abrocitinibalitretinoincrisaborolecromoglicic aciddelgocitiniblebrikizumabnemolizumabpimecrolimusruxolitinibtacrolimustralokinumab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Chronic sinusitis indication 40055000
Prurigo nodularis indication 63501000
Asthma indication 195967001 DOID:2841
Eosinophilic esophagitis indication 235599003 DOID:13922




šŸ¶ Veterinary Drug Use

None

šŸ¶ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-4 receptor subunit alpha Membrane receptor ANTIBODY BINDING IC50 11.06 IUPHAR DRUG LABEL

External reference:

IDSource
420K487FSG UNII
4036554 VANDF
C3660996 UMLSCUI
CHEBI:753623 CHEBI
CHEMBL2108675 ChEMBL_ID
DB12159 DRUGBANK_ID
D10354 KEGG_DRUG
9669 INN_ID
C582203 MESH_SUPPLEMENTAL_RECORD_UI
7574 IUPHAR_LIGAND_ID
733487000 SNOMEDCT_US
763589007 SNOMEDCT_US
255128 MMSL
32580 MMSL
d08549 MMSL
017152 NDDF
1876376 RXNORM

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5911 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5911 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5914 INJECTION, SOLUTION 300 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5914 INJECTION, SOLUTION 300 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5915 INJECTION, SOLUTION 300 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5915 INJECTION, SOLUTION 300 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5918 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5918 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5919 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections
Dupixent HUMAN PRESCRIPTION DRUG LABEL 1 0024-5919 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 31 sections