trastuzumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4979 180288-69-1

Description:

MoleculeDescription

Synonyms:

  • trastuzumab-dkst
  • ogivri
  • trastuzumab
  • herceptin
  • trastuzumab (genetical recombination)
The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Trastuzumab products have been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Trastuzumab products are mediators of antibody-dependent cellular cytotoxicity (ADCC). In vitro, trastuzumab product-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
28.60 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 28, 2000 EMA ROCHE REGISTRATION GMBH
Sept. 25, 1998 FDA GENENTECH
April 4, 2001 PMDA ROCHE JAPAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 6204.85 13.91 2550 142616 51041 90432240
Ejection fraction decreased 3475.25 13.91 1377 143789 24876 90458405
Disease progression 2486.86 13.91 2035 143131 154580 90328701
Metastases to central nervous system 2229.93 13.91 894 144272 16648 90466633
Cardiotoxicity 1764.07 13.91 670 144496 10719 90472562
Diarrhoea 1714.74 13.91 4269 140897 934921 89548360
Palmar-plantar erythrodysaesthesia syndrome 1652.99 13.91 835 144331 27188 90456093
Neuropathy peripheral 1151.60 13.91 1252 143914 135718 90347563
Neutropenia 911.22 13.91 1434 143732 223470 90259811
Chills 867.74 13.91 1063 144103 130918 90352363
Febrile neutropenia 814.58 13.91 1130 144036 157219 90326062
Metastases to bone 768.92 13.91 490 144676 25015 90458266
Malignant neoplasm progression 718.92 13.91 871 144295 105999 90377282
Metastases to lung 714.45 13.91 396 144770 15595 90467686
Metastases to liver 707.45 13.91 487 144679 28320 90454961
Cardiac dysfunction 664.75 13.91 241 144925 3356 90479925
Drug ineffective 655.30 13.91 756 144410 1383542 89099739
Mucosal inflammation 620.06 13.91 602 144564 57023 90426258
Polyneuropathy 576.56 13.91 369 144797 18972 90464309
Bone marrow failure 570.15 13.91 447 144719 31774 90451507
Left ventricular dysfunction 547.33 13.91 323 144843 14346 90468935
Cardiac failure 514.88 13.91 749 144417 108747 90374534
Joint swelling 509.77 13.91 95 145071 503205 89980076
Synovitis 500.83 13.91 5 145161 329747 90153534
Systemic lupus erythematosus 500.27 13.91 18 145148 361878 90121403
Metastases to lymph nodes 488.26 13.91 277 144889 11412 90471869
Rheumatoid arthritis 484.63 13.91 23 145143 362591 90120690
Contraindicated product administered 476.62 13.91 7 145159 320132 90163149
Interstitial lung disease 475.44 13.91 599 144567 75806 90407475
Breast cancer metastatic 454.25 13.91 290 144876 14842 90468439
Neoplasm progression 449.24 13.91 449 144717 44037 90439244
Drug hypersensitivity 435.57 13.91 104 145062 463505 90019776
Breast cancer recurrent 423.98 13.91 197 144969 5306 90477975
Arthropathy 422.00 13.91 47 145119 366195 90117086
Hepatic function abnormal 382.95 13.91 420 144746 45868 90437413
Cardiomyopathy 382.90 13.91 292 144874 19914 90463367
Condition aggravated 366.85 13.91 253 144913 595292 89887989
Abdominal discomfort 365.10 13.91 154 145012 477174 90006107
Therapeutic product effect decreased 354.10 13.91 23 145143 277548 90205733
Glossodynia 351.86 13.91 49 145117 321730 90161551
Helicobacter infection 346.42 13.91 3 145163 226847 90256434
Pneumonitis 334.93 13.91 383 144783 43787 90439494
Neutrophil count decreased 326.97 13.91 483 144683 71049 90412232
Pleural effusion 322.78 13.91 615 144551 111376 90371905
Death 318.96 13.91 1511 143655 455040 90028241
Metastasis 313.12 13.91 166 145000 5971 90477310
Epistaxis 310.25 13.91 518 144648 84607 90398674
Metastases to skin 310.14 13.91 120 145046 2020 90481261
Duodenal ulcer perforation 302.23 13.91 12 145154 221276 90262005
Fibromyalgia 292.99 13.91 8 145158 206261 90277020
Peripheral sensory neuropathy 291.93 13.91 183 144983 9067 90474214
Wound 290.24 13.91 65 145101 302915 90180366
Nausea 281.25 13.91 2860 142306 1107456 89375825
Treatment failure 279.73 13.91 71 145095 303857 90179424
Sinusitis 278.15 13.91 101 145065 342987 90140294
Hyperpyrexia 278.01 13.91 141 145025 4620 90478661
Swelling 270.02 13.91 169 144997 418889 90064392
White blood cell count decreased 269.80 13.91 729 144437 166380 90316901
Lymphoedema 265.54 13.91 201 144965 13552 90469729
Anaemia 259.65 13.91 1186 143980 351616 90131665
Osteonecrosis of jaw 253.43 13.91 313 144853 38790 90444491
Mobility decreased 252.08 13.91 48 145118 250686 90232595
Hypokalaemia 247.79 13.91 607 144559 130509 90352772
Pyrexia 247.41 13.91 1856 143310 658629 89824652
Weight increased 246.03 13.91 186 144980 417741 90065540
Irritable bowel syndrome 242.93 13.91 25 145141 207423 90275858
Injury 241.20 13.91 20 145146 197329 90285952
Neutropenic sepsis 234.62 13.91 210 144956 17920 90465361
Confusional state 233.63 13.91 167 144999 386038 90097243
Thrombocytopenia 229.57 13.91 796 144370 207929 90275352
Skin toxicity 226.30 13.91 139 145027 6640 90476641
Fall 225.45 13.91 264 144902 481546 90001735
Maternal exposure during pregnancy 225.35 13.91 150 145016 359913 90123368
Blood cholesterol increased 224.20 13.91 33 145133 207979 90275302
Ventricular dysfunction 219.33 13.91 111 145055 3620 90479661
Completed suicide 216.48 13.91 3 145163 145055 90338226
Neurotoxicity 211.76 13.91 214 144952 21253 90462028
Pericarditis 209.81 13.91 85 145081 270066 90213215
Drug intolerance 207.50 13.91 247 144919 447344 90035937
Asthenia 204.22 13.91 1508 143658 532243 89951038
Platelet count decreased 201.75 13.91 578 144588 136391 90346890
Folliculitis 201.44 13.91 41 145125 204312 90278969
Musculoskeletal stiffness 200.18 13.91 113 145053 296419 90186862
Granulocyte count decreased 198.95 13.91 91 145075 2361 90480920
Pain 198.69 13.91 872 144294 995469 89487812
Computerised tomogram thorax abnormal 193.41 13.91 85 145081 2002 90481279
Impaired healing 193.05 13.91 67 145099 234132 90249149
Type 2 diabetes mellitus 191.77 13.91 45 145121 203199 90280082
Hyperbilirubinaemia 191.47 13.91 167 144999 13769 90469512
Asthma 189.98 13.91 75 145091 242085 90241196
Wheezing 189.65 13.91 72 145094 238008 90245273
Hepatic enzyme increased 187.26 13.91 181 144985 360555 90122726
Osteoarthritis 185.34 13.91 43 145123 195687 90287594
Psoriasis 183.25 13.91 14 145152 147740 90335541
Discomfort 183.07 13.91 106 145060 274229 90209052
Onycholysis 181.69 13.91 83 145083 2147 90481134
Product use issue 181.38 13.91 157 145009 329762 90153519
Bone pain 180.49 13.91 342 144824 61641 90421640
Recall phenomenon 180.02 13.91 63 145103 786 90482495
Paronychia 177.07 13.91 127 145039 7879 90475402
Vascular device infection 173.89 13.91 148 145018 11804 90471477
Haematotoxicity 171.79 13.91 150 145016 12385 90470896
Leukopenia 170.18 13.91 447 144719 100263 90383018
Onychoclasis 169.70 13.91 120 145046 7279 90476002
Bursitis 167.53 13.91 11 145155 131643 90351638
Exposure during pregnancy 166.49 13.91 87 145079 238323 90244958
Contusion 166.29 13.91 98 145068 251118 90232163
Vomiting 164.43 13.91 1956 143210 786337 89696944
Ventricular hypokinesia 164.37 13.91 104 145062 5237 90478044
Mitral valve incompetence 160.15 13.91 189 144977 22335 90460946
Product dose omission issue 157.66 13.91 141 145025 291546 90191735
Blister 154.45 13.91 110 145056 254888 90228393
Therapeutic product effect incomplete 153.80 13.91 59 145107 193837 90289444
Loss of personal independence in daily activities 152.78 13.91 19 145147 136086 90347195
Product use in unapproved indication 151.03 13.91 190 144976 336046 90147235
Urticaria 149.77 13.91 168 144998 312566 90170715
Joint range of motion decreased 149.70 13.91 20 145146 135623 90347658
Migraine 149.26 13.91 59 145107 190333 90292948
Pericardial effusion 148.89 13.91 235 144931 36598 90446683
Transaminases increased 148.57 13.91 236 144930 36956 90446325
Metastases to meninges 146.58 13.91 85 145081 3650 90479631
Lymphangiosis carcinomatosa 144.99 13.91 65 145101 1607 90481674
Alanine aminotransferase increased 144.80 13.91 468 144698 117870 90365411
Drug interaction 143.08 13.91 139 145027 276314 90206967
Gait inability 140.99 13.91 31 145135 146425 90336856
Lip dry 139.41 13.91 5 145161 100950 90382331
Dysgeusia 138.41 13.91 278 144888 52282 90430999
Metastatic neoplasm 136.41 13.91 89 145077 4726 90478555
Blood bilirubin increased 132.96 13.91 245 144921 43225 90440056
Aspartate aminotransferase increased 132.24 13.91 414 144752 102523 90380758
Dermatitis acneiform 131.89 13.91 97 145069 6257 90477024
Metastases to spine 130.71 13.91 79 145087 3664 90479617
Hypercholesterolaemia 129.64 13.91 8 145158 100884 90382397
Gastrointestinal toxicity 129.15 13.91 113 145053 9354 90473927
Hospitalisation 127.67 13.91 25 145141 128075 90355206
Peripheral swelling 125.64 13.91 299 144867 412807 90070474
Recurrent cancer 123.99 13.91 66 145100 2393 90480888
Lacrimation increased 123.98 13.91 183 144983 26879 90456402
Acute myeloid leukaemia 122.27 13.91 158 145008 20482 90462799
Nail toxicity 120.20 13.91 39 145127 379 90482902
Alveolitis 119.21 13.91 69 145097 2952 90480329
Knee arthroplasty 118.92 13.91 3 145163 83179 90400102
Overdose 118.56 13.91 52 145114 157657 90325624
Drug abuse 117.61 13.91 3 145163 82344 90400937
Congestive cardiomyopathy 117.21 13.91 96 145070 7258 90476023
Nail discolouration 114.70 13.91 69 145097 3173 90480108
Chest discomfort 113.57 13.91 481 144685 137884 90345397
Myalgia 113.53 13.91 568 144598 174557 90308724
Erysipelas 113.47 13.91 103 145063 8949 90474332
Injection site pain 113.17 13.91 69 145097 173630 90309651
Peripheral venous disease 113.02 13.91 5 145161 83916 90399365
Arthritis 112.49 13.91 64 145102 167251 90316030
Osteonecrosis 111.04 13.91 171 144995 26070 90457211
Dehydration 110.46 13.91 608 144558 193839 90289442
Dyspnoea 109.52 13.91 1999 143167 878956 89604325
Road traffic accident 109.39 13.91 20 145146 107606 90375675
Radiation skin injury 109.10 13.91 47 145119 1053 90482228
Cellulitis 108.82 13.91 358 144808 90979 90392302
HER2 positive breast cancer 107.87 13.91 37 145129 433 90482848
Inappropriate schedule of product administration 105.69 13.91 54 145112 149879 90333402
Cough 104.62 13.91 975 144191 367987 90115294
Nail dystrophy 104.07 13.91 48 145118 1270 90482011
Biopsy lung abnormal 103.86 13.91 28 145138 131 90483150
Breast pain 103.01 13.91 104 145062 10314 90472967
Hepatotoxicity 102.71 13.91 227 144939 45615 90437666
Oligohydramnios 102.37 13.91 88 145078 7113 90476168
Radiation necrosis 102.03 13.91 39 145127 634 90482647
Hot flush 100.42 13.91 264 144902 59224 90424057
Decreased appetite 99.82 13.91 981 144185 375559 90107722
Fatigue 97.84 13.91 2477 142689 1151546 89331735
Skin fissures 97.18 13.91 142 145024 20667 90462614
Arthralgia 95.75 13.91 793 144373 777729 89705552
Sciatica 94.50 13.91 23 145143 101359 90381922
Adverse event 94.31 13.91 35 145131 117383 90365898
Colitis 94.18 13.91 286 144880 69656 90413625
Depression 93.39 13.91 215 144951 300386 90182895
Autoimmune disorder 93.12 13.91 8 145158 76736 90406545
Computerised tomogram thorax 92.63 13.91 34 145132 491 90482790
Breast neoplasm 89.94 13.91 46 145120 1534 90481747
Somnolence 89.86 13.91 122 145044 208962 90274319
Delirium 89.20 13.91 28 145138 104331 90378950
Inflammation 88.70 13.91 93 145073 178499 90304782
Disease recurrence 88.40 13.91 190 144976 37463 90445818
Prescribed underdose 87.88 13.91 9 145157 75010 90408271
Constipation 87.13 13.91 756 144410 279639 90203642
Sleep disorder 86.68 13.91 114 145052 197916 90285365
Mastitis 86.45 13.91 56 145110 2937 90480344
Device related infection 86.09 13.91 151 145015 25635 90457646
Hepatic failure 85.94 13.91 194 144972 39534 90443747
Suicide attempt 85.90 13.91 10 145156 75389 90407892
Lung infiltration 85.89 13.91 114 145052 15168 90468113
Atelectasis 85.50 13.91 146 145020 24263 90459018
Second primary malignancy 85.50 13.91 94 145072 10284 90472997
Ear infection 85.41 13.91 7 145159 69768 90413513
Agranulocytosis 83.75 13.91 178 144988 34824 90448457
Off label use 83.58 13.91 2332 142834 1099920 89383361
Invasive ductal breast carcinoma 82.76 13.91 81 145085 7737 90475544
Aortitis 81.80 13.91 41 145125 1309 90481972
Neutropenic infection 81.33 13.91 45 145121 1764 90481517
Blood lactate dehydrogenase increased 80.36 13.91 147 145019 25785 90457496
Foot deformity 78.88 13.91 4 145162 59647 90423634
Wound infection 78.52 13.91 36 145130 106366 90376915
Drug ineffective for unapproved indication 78.05 13.91 8 145158 66636 90416645
No adverse event 77.89 13.91 263 144903 67719 90415562
Breast cancer 77.28 13.91 225 144941 53536 90429745
Organising pneumonia 77.24 13.91 77 145089 7520 90475761
Lymphadenopathy 77.11 13.91 203 144963 45572 90437709
Dry skin 76.82 13.91 312 144854 87761 90395520
Hepatitis B reactivation 76.53 13.91 58 145108 3916 90479365
Ascites 75.67 13.91 207 144959 47533 90435748
Nasopharyngitis 74.41 13.91 367 144799 406737 90076544
Product quality issue 73.92 13.91 18 145148 79307 90403974
Systolic dysfunction 73.84 13.91 43 145123 1861 90481420
Metastases to pleura 73.60 13.91 44 145122 2000 90481281
Pulmonary embolism 73.54 13.91 408 144758 130412 90352869
Injection site swelling 73.25 13.91 6 145160 59833 90423448
Carcinoembryonic antigen increased 72.91 13.91 46 145120 2304 90480977
Obesity 72.87 13.91 39 145127 105468 90377813
Tumour marker increased 72.64 13.91 66 145100 5741 90477540
Mastectomy 72.52 13.91 44 145122 2055 90481226
Hypertransaminasaemia 72.47 13.91 107 145059 15718 90467563
Bone erosion 71.92 13.91 3 145163 53018 90430263
Cardiac failure congestive 71.79 13.91 331 144835 98363 90384918
Injection site erythema 71.65 13.91 34 145132 98468 90384813
Injection site reaction 71.37 13.91 29 145137 92051 90391230
Infection 71.12 13.91 318 144848 361776 90121505
Night sweats 71.01 13.91 61 145105 128705 90354576
Toxic cardiomyopathy 70.93 13.91 25 145141 319 90482962
Gamma-glutamyltransferase increased 70.87 13.91 175 144991 37777 90445504
Injection site bruising 70.82 13.91 3 145163 52304 90430977
Dislocation of vertebra 70.24 13.91 5 145161 55963 90427318
Madarosis 69.96 13.91 53 145113 3576 90479705
Frequent bowel movements 68.89 13.91 6 145160 56929 90426352
Bronchial polyp 68.84 13.91 18 145148 73 90483208
Multifocal micronodular pneumocyte hyperplasia 68.84 13.91 18 145148 73 90483208
Neoplasm 68.81 13.91 78 145088 8825 90474456
Ejection fraction abnormal 68.03 13.91 45 145121 2446 90480835
Anxiety 67.06 13.91 262 144904 309510 90173771
Radiation pneumonitis 66.91 13.91 40 145126 1818 90481463
Onychalgia 66.86 13.91 34 145132 1120 90482161
Gait disturbance 66.72 13.91 205 144961 260291 90222990
Blepharospasm 66.67 13.91 6 145160 55439 90427842
Memory impairment 66.27 13.91 135 145031 197109 90286172
Therapy non-responder 65.85 13.91 73 145093 136631 90346650
Cystitis haemorrhagic 65.73 13.91 61 145105 5452 90477829
Acute interstitial pneumonitis 65.21 13.91 30 145136 789 90482492
Osteoporosis 64.76 13.91 37 145129 96494 90386787
Adverse drug reaction 64.70 13.91 55 145111 116646 90366635
Acute respiratory distress syndrome 64.20 13.91 142 145024 28544 90454737
Erythema 62.50 13.91 601 144565 228645 90254636
Temperature intolerance 61.93 13.91 86 145080 11944 90471337
Injection site pruritus 61.67 13.91 7 145159 53827 90429454
Breast disorder 61.43 13.91 44 145122 2723 90480558
Dermatomyositis 60.12 13.91 47 145119 3323 90479958
Toxicity to various agents 60.06 13.91 247 144919 287599 90195682
Blood alkaline phosphatase increased 59.55 13.91 191 144975 47888 90435393
Sarcoid-like reaction 58.71 13.91 19 145147 183 90483098
Sedation 58.50 13.91 5 145161 48166 90435115
Metastases to breast 56.49 13.91 22 145144 377 90482904
Lower limb fracture 56.43 13.91 33 145133 84980 90398301
Axillary pain 56.39 13.91 39 145127 2282 90480999
Back injury 56.18 13.91 5 145161 46617 90436664
Drug reaction with eosinophilia and systemic symptoms 56.12 13.91 3 145163 42755 90440526
Bone lesion 55.99 13.91 60 145106 6377 90476904
Microvascular coronary artery disease 55.99 13.91 20 145146 266 90483015
Nasal congestion 55.91 13.91 32 145134 83382 90399899
Myocarditis 55.67 13.91 88 145078 13718 90469563
Intentional product misuse 55.06 13.91 38 145128 89566 90393715
Incorrect dose administered 54.76 13.91 29 145137 78901 90404380
Sensory disturbance 53.73 13.91 92 145074 15321 90467960
Amnesia 53.30 13.91 57 145109 108448 90374833
Medication error 53.23 13.91 35 145131 84617 90398664
Brain oedema 53.17 13.91 98 145068 17287 90465994
Joint dislocation 53.13 13.91 5 145161 44577 90438704
Vulvovaginal dryness 53.03 13.91 44 145122 3387 90479894
Nail infection 52.79 13.91 39 145127 2533 90480748
Nail bed inflammation 52.76 13.91 34 145132 1767 90481514
Lactic acidosis 52.09 13.91 9 145157 50454 90432827
Blood uric acid decreased 51.96 13.91 26 145140 827 90482454
Alopecia areata 51.66 13.91 35 145131 1980 90481301
Tumour pain 51.32 13.91 34 145132 1853 90481428
Nodular regenerative hyperplasia 51.21 13.91 24 145142 659 90482622
Hypersensitivity 50.93 13.91 474 144692 454203 90029078
Dermatitis 50.87 13.91 111 145055 22109 90461172
Neoplasm recurrence 50.80 13.91 42 145124 3217 90480064
Hydrothorax 50.05 13.91 27 145139 1006 90482275
Pulmonary toxicity 49.99 13.91 76 145090 11455 90471826
Mouth ulceration 49.68 13.91 159 145007 39815 90443466
Pseudocirrhosis 49.47 13.91 26 145140 918 90482363
Central nervous system lesion 49.42 13.91 76 145090 11570 90471711
Bronchitis 49.40 13.91 107 145059 152820 90330461
Dyspnoea exertional 49.32 13.91 238 144928 72050 90411231
Hypoxia 49.13 13.91 238 144928 72161 90411120
Left ventricular dilatation 48.73 13.91 23 145143 642 90482639
Metastases to chest wall 48.53 13.91 23 145143 648 90482633
Feeling abnormal 48.44 13.91 124 145042 167111 90316170
Aortic valve incompetence 47.78 13.91 56 145110 6568 90476713
Flushing 47.74 13.91 273 144893 88218 90395063
Lupus-like syndrome 47.68 13.91 10 145156 48836 90434445
Cardiac disorder 47.63 13.91 199 144967 56673 90426608
Peripheral motor neuropathy 47.58 13.91 33 145133 1940 90481341
Disability 47.43 13.91 5 145161 40740 90442541
Blood creatinine decreased 46.86 13.91 55 145111 6460 90476821
Hyperfibrinogenaemia 46.23 13.91 11 145155 27 90483254
Tonsillar disorder 46.23 13.91 27 145139 1175 90482106
Hepatic lesion 46.07 13.91 51 145115 5622 90477659
Pulmonary mass 45.83 13.91 125 145041 28647 90454634
Cardiac ventricular thrombosis 45.01 13.91 26 145140 1108 90482173
Breast mass 44.88 13.91 65 145101 9382 90473899
Portal hypertension 44.78 13.91 46 145120 4655 90478626
Hip arthroplasty 44.64 13.91 34 145132 76174 90407107
Suicidal ideation 44.49 13.91 32 145134 73823 90409458
Hair colour changes 44.27 13.91 40 145126 3454 90479827
Acute pulmonary oedema 44.19 13.91 65 145101 9515 90473766
Enterocolitis infectious 44.19 13.91 32 145134 2015 90481266
Tremor 43.93 13.91 406 144760 152767 90330514
Coeliac disease 43.82 13.91 9 145157 44601 90438680
Bone marrow infiltration 43.59 13.91 23 145143 819 90482462
Hallucination 43.22 13.91 26 145140 65933 90417348
Back pain 43.19 13.91 731 144435 316444 90166837
Performance status decreased 42.81 13.91 43 145123 4237 90479044
Lung disorder 42.74 13.91 112 145054 149771 90333510
Seroma 42.70 13.91 37 145129 3023 90480258
Therapy partial responder 42.60 13.91 103 145063 21940 90461341
Enterocolitis 42.48 13.91 67 145099 10423 90472858
Upper respiratory tract infection 42.09 13.91 89 145077 128229 90355052
Immunodeficiency 41.90 13.91 9 145157 43225 90440056
Therapy interrupted 41.83 13.91 14 145152 50094 90433187
Keratitis 41.46 13.91 41 145125 3965 90479316
Illness 41.45 13.91 42 145124 81927 90401354
Dysuria 40.43 13.91 147 145019 39254 90444027
Nasal mucosal disorder 40.02 13.91 29 145137 1828 90481453
Sepsis 39.81 13.91 452 144714 179362 90303919
Axillary vein thrombosis 39.79 13.91 17 145149 373 90482908
Hepatopulmonary syndrome 39.72 13.91 12 145154 90 90483191
Streptococcal sepsis 39.56 13.91 38 145128 3546 90479735
Meibomian gland dysfunction 38.85 13.91 15 145151 251 90483030
Intentional product use issue 38.73 13.91 197 144969 216695 90266586
Therapy cessation 38.61 13.91 6 145160 36355 90446926
Intracranial pressure increased 38.57 13.91 51 145115 6760 90476521
Liver injury 38.34 13.91 142 145024 170425 90312856
Pleural disorder 38.32 13.91 20 145146 696 90482585
Cystitis noninfective 38.04 13.91 25 145141 1344 90481937
Tachycardia 37.96 13.91 403 144763 157270 90326011
Troponin I increased 37.91 13.91 32 145134 2523 90480758
Sense of oppression 37.85 13.91 23 145143 1077 90482204
Ill-defined disorder 37.71 13.91 160 145006 184731 90298550
Treatment noncompliance 37.39 13.91 18 145148 51709 90431572
Eosinophil percentage increased 36.96 13.91 22 145144 992 90482289
Stress cardiomyopathy 36.78 13.91 72 145094 13283 90469998
Cardiac tamponade 36.35 13.91 45 145121 5587 90477694
Rash pustular 36.24 13.91 54 145112 7995 90475286
Fluid retention 36.23 13.91 53 145113 88038 90395243
Hyperaesthesia 36.15 13.91 63 145103 10639 90472642
Influenza 36.06 13.91 109 145057 139155 90344126
Dry mouth 35.88 13.91 162 145004 183897 90299384
Feeling cold 35.74 13.91 111 145055 27354 90455927
Hyperkalaemia 35.54 13.91 31 145135 64933 90418348
Tachypnoea 35.37 13.91 94 145072 21215 90462066
Osteosclerosis 35.36 13.91 39 145127 4281 90479000
Pneumonitis chemical 35.07 13.91 15 145151 330 90482951
Hemianopia 34.91 13.91 28 145138 2054 90481227
Plasma cell myeloma 34.80 13.91 11 145155 40817 90442464
Cardiac failure chronic 34.66 13.91 44 145122 5602 90477679
Jaw operation 34.65 13.91 20 145146 851 90482430
Subclavian vein thrombosis 34.52 13.91 28 145138 2088 90481193
Eastern Cooperative Oncology Group performance status worsened 34.50 13.91 27 145139 1912 90481369
Hair texture abnormal 34.43 13.91 40 145126 4647 90478634
Musculoskeletal pain 34.43 13.91 149 145017 171102 90312179
Tumour lysis syndrome 34.28 13.91 63 145103 11089 90472192
Sleep apnoea syndrome 34.26 13.91 5 145161 31742 90451539
Odynophagia 34.22 13.91 56 145110 8987 90474294
Accidental overdose 34.15 13.91 3 145163 28270 90455011
Red cell distribution width increased 33.85 13.91 66 145100 12141 90471140
Malignant pleural effusion 33.81 13.91 32 145134 2932 90480349
Ejection fraction 33.38 13.91 32 145134 2979 90480302
Excessive eye blinking 33.21 13.91 23 145143 1349 90481932
Abdominal pain upper 32.98 13.91 357 144809 332317 90150964
Chronic obstructive pulmonary disease 32.80 13.91 42 145124 73787 90409494
Brain cancer metastatic 32.65 13.91 12 145154 174 90483107
Anaphylactoid reaction 32.60 13.91 38 145128 4430 90478851
Cystoid macular oedema 32.60 13.91 27 145139 2073 90481208
Retinal detachment 32.50 13.91 47 145119 6775 90476506
Stomatitis 32.39 13.91 619 144547 274079 90209202
Basal cell carcinoma 32.26 13.91 7 145159 33382 90449899
Breast inflammation 31.86 13.91 12 145154 187 90483094
Aggression 31.75 13.91 3 145163 26665 90456616
Swollen tongue 31.71 13.91 17 145149 45939 90437342
Intercepted product preparation error 31.65 13.91 22 145144 1298 90481983
Anaphylactic shock 31.63 13.91 117 145049 31500 90451781
Wrong technique in product usage process 31.50 13.91 41 145125 71530 90411751
Hypoalbuminaemia 31.49 13.91 75 145091 15822 90467459
Breast cellulitis 31.35 13.91 17 145149 640 90482641
Cardiac failure acute 31.28 13.91 63 145103 11866 90471415
Distichiasis 31.09 13.91 8 145158 30 90483251
Blepharitis 31.01 13.91 35 145131 3941 90479340
Vulvovaginal inflammation 30.38 13.91 20 145146 1078 90482203
Catheter site bruise 30.37 13.91 16 145150 568 90482713
Leukonychia 30.33 13.91 9 145157 63 90483218
Blood creatine increased 30.32 13.91 46 145120 6921 90476360
Mucosal dryness 30.19 13.91 31 145135 3136 90480145
Hand dermatitis 30.16 13.91 16 145150 576 90482705
Central vision loss 30.09 13.91 9 145157 65 90483216
Granulomatous lymphadenitis 30.02 13.91 12 145154 221 90483060
Metastases to adrenals 29.98 13.91 19 145147 959 90482322
Papilloedema 29.98 13.91 37 145129 4578 90478703
Diastolic dysfunction 29.92 13.91 47 145119 7286 90475995
Capillary leak syndrome 29.91 13.91 29 145137 2738 90480543
Biliary sepsis 29.84 13.91 19 145147 967 90482314
Jaundice 29.79 13.91 117 145049 32400 90450881
Nail disorder 29.77 13.91 179 144987 58888 90424393
Botryomycosis 29.57 13.91 8 145158 38 90483243
Foetal exposure during pregnancy 29.50 13.91 16 145150 42959 90440322
Dihydropyrimidine dehydrogenase deficiency 29.39 13.91 10 145156 114 90483167
Neurological decompensation 29.34 13.91 32 145134 3469 90479812
Cardiovascular disorder 29.30 13.91 66 145100 13426 90469855
Hypocalcaemia 29.26 13.91 140 145026 42228 90441053
Vocal cord paralysis 29.19 13.91 27 145139 2403 90480878
Gastrooesophageal reflux disease 29.17 13.91 152 145014 166185 90317096
Dyskinesia 29.14 13.91 11 145155 36523 90446758
Nail bed bleeding 28.95 13.91 14 145152 413 90482868
Ulcer haemorrhage 28.74 13.91 4 145162 26317 90456964
Spinal pain 28.69 13.91 72 145094 15695 90467586
Palmar erythema 28.49 13.91 24 145142 1887 90481394
Neck pain 28.22 13.91 91 145075 113872 90369409
Circulatory collapse 28.21 13.91 96 145070 24808 90458473
Orthostatic hypotension 28.09 13.91 16 145150 41811 90441470
Sinus congestion 28.07 13.91 5 145161 27419 90455862
Respiratory tract congestion 28.05 13.91 5 145161 27405 90455876
Glossopharyngeal nerve paralysis 28.02 13.91 8 145158 48 90483233
Tricuspid valve incompetence 27.97 13.91 74 145092 16657 90466624
International normalised ratio increased 27.85 13.91 21 145145 47295 90435986
Pneumocystis jirovecii pneumonia 27.79 13.91 87 145079 21529 90461752
Macular degeneration 27.77 13.91 13 145153 37957 90445324
Hiccups 27.73 13.91 29 145137 2997 90480284
Lymphopenia 27.52 13.91 90 145076 22791 90460490
Joint injury 27.49 13.91 9 145157 32655 90450626
Plantar erythema 27.35 13.91 11 145155 206 90483075
Pneumothorax 27.33 13.91 80 145086 19087 90464194
Osteolysis 27.26 13.91 31 145135 3519 90479762
Gingival bleeding 27.06 13.91 68 145098 14835 90468446
Pancreatic haemorrhage 27.05 13.91 7 145159 27 90483254
Dermatitis atopic 27.02 13.91 3 145163 23469 90459812
Tumour invasion 26.79 13.91 12 145154 296 90482985
Skin mass 26.76 13.91 45 145121 7385 90475896
Impaired quality of life 26.53 13.91 3 145163 23141 90460140
Anal inflammation 26.53 13.91 13 145153 395 90482886
Unresponsive to stimuli 26.45 13.91 14 145152 38107 90445174
Therapeutic response decreased 26.38 13.91 66 145100 89663 90393618
Breast oedema 26.25 13.91 8 145158 62 90483219
Dysaesthesia 26.20 13.91 37 145129 5218 90478063
Hyperchlorhydria 26.14 13.91 23 145143 1918 90481363
Blood phosphorus decreased 25.93 13.91 36 145130 4998 90478283
Metastases to the mediastinum 25.91 13.91 15 145151 642 90482639
Blood magnesium decreased 25.82 13.91 69 145097 15624 90467657
Secondary cerebellar degeneration 25.82 13.91 8 145158 66 90483215
Bladder irritation 25.76 13.91 12 145154 325 90482956
Nasal disorder 25.71 13.91 29 145137 3263 90480018
Pseudomonal sepsis 25.58 13.91 33 145133 4269 90479012
Eosinophilia 25.58 13.91 7 145159 28526 90454755
Blood lactate dehydrogenase abnormal 25.43 13.91 13 145153 433 90482848
Gingival pain 25.34 13.91 51 145115 9601 90473680
Soft tissue infection 25.19 13.91 27 145139 2870 90480411
Vessel puncture site bruise 25.16 13.91 13 145153 443 90482838
Depressed level of consciousness 25.13 13.91 49 145117 72735 90410546
Chronic sinusitis 25.11 13.91 4 145162 23798 90459483
Peripheral sensorimotor neuropathy 25.10 13.91 23 145143 2022 90481259
Device issue 25.10 13.91 8 145158 29529 90453752
Mean platelet volume decreased 24.79 13.91 27 145139 2923 90480358
Muscle spasms 24.67 13.91 271 144895 251612 90231669
Ischaemia 24.53 13.91 36 145130 5259 90478022
Normal newborn 24.48 13.91 4 145162 23358 90459923
Bone disorder 24.35 13.91 87 145079 23033 90460248
Post-traumatic pain 24.33 13.91 13 145153 475 90482806
Hypervolaemia 24.29 13.91 11 145155 32746 90450535
Tumour marker abnormal 24.27 13.91 12 145154 372 90482909
Acute leukaemia 24.24 13.91 18 145148 1178 90482103
Bile duct stenosis 24.18 13.91 21 145145 1721 90481560
Oxygen saturation decreased 24.14 13.91 271 144895 107212 90376069
Metastases to heart 24.12 13.91 10 145156 203 90483078
Onychomycosis 24.11 13.91 15 145151 37361 90445920
Endometrial cancer recurrent 24.10 13.91 7 145159 45 90483236
Orthopnoea 24.09 13.91 41 145125 6794 90476487
Hyperthermia 24.08 13.91 52 145114 10283 90472998
Gastritis 23.97 13.91 131 145035 41622 90441659
Chronic kidney disease 23.94 13.91 27 145139 50164 90433117
Palpitations 23.94 13.91 329 144837 136399 90346882
Neuromuscular toxicity 23.88 13.91 11 145155 290 90482991
Diabetes mellitus 23.88 13.91 42 145124 64833 90418448
Dyschezia 23.69 13.91 26 145140 2839 90480442
Nail ridging 23.67 13.91 13 145153 502 90482779
Injection site rash 23.49 13.91 5 145161 24168 90459113
Acoustic stimulation tests abnormal 23.45 13.91 8 145158 92 90483189
Hydrocephalus 23.41 13.91 38 145128 6056 90477225
Sequestrectomy 23.37 13.91 15 145151 774 90482507
Multicentric reticulohistiocytosis 23.26 13.91 5 145161 6 90483275
Bone sequestrum 23.22 13.91 19 145147 1434 90481847
Protein total decreased 23.00 13.91 41 145125 7048 90476233
C-reactive protein increased 22.99 13.91 183 144983 181206 90302075
Cytomegalovirus infection 22.97 13.91 7 145159 26595 90456686
Calcium ionised increased 22.97 13.91 10 145156 230 90483051
Gamma-glutamyltransferase abnormal 22.94 13.91 13 145153 534 90482747
Lymphocyte count decreased 22.90 13.91 114 145052 34936 90448345
Headache 22.74 13.91 1140 144026 861606 89621675
Lymphangitis 22.59 13.91 16 145150 973 90482308
Retracted nipple 22.44 13.91 6 145160 27 90483254
Embolism 22.43 13.91 48 145118 9433 90473848
Breast induration 22.27 13.91 6 145160 28 90483253
Acute hepatic failure 22.16 13.91 83 145083 22478 90460803
Entropion 22.15 13.91 8 145158 110 90483171
Noninfective conjunctivitis 22.10 13.91 6 145160 29 90483252
Hepatic mass 22.01 13.91 22 145144 2155 90481126
Hepatic cytolysis 21.96 13.91 103 145063 30813 90452468
Superior vena cava syndrome 21.87 13.91 14 145152 719 90482562
Oedema 21.87 13.91 210 144956 200085 90283196
Arrhythmia 21.79 13.91 129 145037 42203 90441078
Osteitis condensans 21.76 13.91 6 145160 31 90483250
Physical capacity evaluation 21.75 13.91 4 145162 0 90483281
Perforation 21.74 13.91 21 145145 1973 90481308
Megacolon 21.70 13.91 22 145144 2192 90481089
Laboratory test abnormal 21.67 13.91 21 145145 41833 90441448
Oropharyngeal candidiasis 21.63 13.91 17 145149 1211 90482070
Asthenopia 21.63 13.91 25 145141 2889 90480392
Inflammatory carcinoma of the breast 21.58 13.91 7 145159 68 90483213
Lymphadenopathy mediastinal 21.56 13.91 26 145140 3141 90480140
Ventricular extrasystoles 21.54 13.91 58 145108 13192 90470089
Neurological symptom 21.45 13.91 39 145127 6808 90476473
Metastases to bone marrow 21.45 13.91 13 145153 606 90482675
Eye irritation 21.42 13.91 14 145152 33964 90449317
Tooth extraction 21.40 13.91 53 145113 11460 90471821
Coagulation factor decreased 21.21 13.91 9 145157 194 90483087
Red blood cell count decreased 21.19 13.91 137 145029 46214 90437067
Pulmonary oedema 21.16 13.91 171 144995 61909 90421372
Oral pain 21.14 13.91 106 145060 32577 90450704
Paralysis recurrent laryngeal nerve 21.13 13.91 7 145159 73 90483208
Blood pressure fluctuation 21.10 13.91 32 145134 52381 90430900
Bronchospasm 21.02 13.91 77 145089 20632 90462649
Product prescribing error 21.02 13.91 11 145155 30134 90453147
Herpangina 21.01 13.91 6 145160 36 90483245
Lower respiratory tract infection 21.00 13.91 279 144887 250380 90232901
Myocardial ischaemia 21.00 13.91 59 145107 13755 90469526
Left ventricular enlargement 20.96 13.91 7 145159 75 90483206
Rhabdomyolysis 20.92 13.91 31 145135 51225 90432056
Metastases to pituitary gland 20.81 13.91 5 145161 13 90483268
Lipoprotein increased 20.81 13.91 5 145161 13 90483268
Lymphangiopathy 20.81 13.91 5 145161 13 90483268
Vascular fragility 20.71 13.91 9 145157 206 90483075
Dizziness 20.66 13.91 754 144412 588530 89894751
Hepatic cirrhosis 20.63 13.91 44 145122 63209 90420072
Full blood count abnormal 20.58 13.91 17 145149 36580 90446701
Transaminases 20.56 13.91 7 145159 80 90483201
Colitis ulcerative 20.43 13.91 41 145125 60225 90423056
Dilatation ventricular 20.41 13.91 22 145144 2354 90480927
Sopor 20.37 13.91 7 145159 24637 90458644
Kidney infection 20.34 13.91 8 145158 25908 90457373
Hypertension 20.21 13.91 568 144598 456964 90026317
Psychological trauma 20.18 13.91 17 145149 1336 90481945
Hepatic cyst 20.05 13.91 37 145129 6531 90476750
Chromosomal mutation 20.04 13.91 5 145161 16 90483265
Paraesthesia 20.03 13.91 534 144632 249792 90233489
Hepatic neoplasm 20.03 13.91 21 145145 2177 90481104
Electrocardiogram QT prolonged 20.00 13.91 55 145111 72401 90410880
Folate deficiency 19.96 13.91 25 145141 3140 90480141
Dyspnoea at rest 19.96 13.91 31 145135 4760 90478521
Breast haemorrhage 19.95 13.91 9 145157 226 90483055
Telangiectasia 19.86 13.91 17 145149 1366 90481915
Device dislocation 19.81 13.91 13 145153 31469 90451812
Ear pain 19.78 13.91 39 145127 57663 90425618
Lipidosis 19.75 13.91 6 145160 46 90483235
Gastroenteritis radiation 19.69 13.91 12 145154 565 90482716
Hyperproteinaemia 19.69 13.91 8 145158 154 90483127
Hepatic cancer metastatic 19.68 13.91 11 145155 440 90482841
Meibomianitis 19.63 13.91 6 145160 47 90483234
Bone cancer metastatic 19.62 13.91 9 145157 235 90483046
Corneal disorder 19.49 13.91 20 145146 2022 90481259
Abnormal behaviour 19.46 13.91 6 145160 22622 90460659
Coma 19.41 13.91 56 145110 72576 90410705
Procedural pain 19.38 13.91 15 145151 33345 90449936
Sinus disorder 19.37 13.91 16 145150 34431 90448850
Toxic optic neuropathy 19.28 13.91 9 145157 245 90483036
Gram stain positive 19.27 13.91 7 145159 98 90483183
Dysentery 19.11 13.91 15 145151 1067 90482214
Taste disorder 19.10 13.91 44 145122 61502 90421779
Conjunctivitis 18.99 13.91 89 145077 26617 90456664
Breast sarcoma 18.99 13.91 4 145162 4 90483277
Congenital syphilitic osteochondritis 18.98 13.91 5 145161 21 90483260
Pulmonary fibrosis 18.98 13.91 98 145068 107405 90375876
B-cell type acute leukaemia 18.91 13.91 12 145154 607 90482674
Pituitary tumour 18.87 13.91 14 145152 915 90482366
Joint stiffness 18.85 13.91 63 145103 77979 90405302
Brachial plexopathy 18.82 13.91 9 145157 259 90483022
Barotrauma 18.75 13.91 8 145158 175 90483106
Intracardiac thrombus 18.69 13.91 21 145145 2353 90480928
Hormone receptor positive breast cancer 18.69 13.91 13 145153 768 90482513
Device occlusion 18.61 13.91 44 145122 9238 90474043
Limb injury 18.52 13.91 14 145152 31494 90451787
Catheter site inflammation 18.50 13.91 14 145152 943 90482338
Hyperaemia 18.50 13.91 22 145144 2620 90480661
Skin exfoliation 18.45 13.91 178 144988 67735 90415546
Brain natriuretic peptide decreased 18.43 13.91 6 145160 59 90483222
Apical granuloma 18.43 13.91 6 145160 59 90483222
Device difficult to use 18.37 13.91 3 145163 17522 90465759
Haemorrhoids 18.27 13.91 88 145078 26614 90456667
Multiple sclerosis 18.20 13.91 11 145155 27829 90455452
Myeloproliferative neoplasm 18.18 13.91 12 145154 650 90482631
Gastric disorder 18.17 13.91 16 145150 33368 90449913
Electric shock sensation 18.00 13.91 17 145149 1553 90481728
Pericardial effusion malignant 17.99 13.91 8 145158 194 90483087
Pleomorphic adenoma 17.95 13.91 5 145161 27 90483254
Hypertensive crisis 17.95 13.91 66 145100 17718 90465563
Atrial thrombosis 17.92 13.91 20 145146 2225 90481056
Lethargy 17.91 13.91 167 144999 62972 90420309
Nephrolithiasis 17.87 13.91 32 145134 49053 90434228
Anal erythema 17.82 13.91 9 145157 292 90482989
Xerophthalmia 17.82 13.91 12 145154 672 90482609
Cyanosis 17.82 13.91 70 145096 19385 90463896
Drug resistance 17.79 13.91 96 145070 30353 90452928
Skin hyperpigmentation 17.74 13.91 36 145130 6815 90476466
Cardiac output decreased 17.71 13.91 14 145152 1006 90482275
Toxic neuropathy 17.69 13.91 11 145155 537 90482744
Laryngitis 17.66 13.91 34 145132 50719 90432562
Gingival swelling 17.57 13.91 30 145136 4983 90478298
Osteochondrosis 17.49 13.91 18 145148 1825 90481456
Arachnoid cyst 17.49 13.91 9 145157 304 90482977
Immune thrombocytopenia 17.47 13.91 54 145112 13272 90470009
Autonomic neuropathy 17.42 13.91 16 145150 1411 90481870
Polyarthritis 17.42 13.91 4 145162 18346 90464935
Gout 17.41 13.91 3 145163 16856 90466425
Overflow diarrhoea 17.41 13.91 7 145159 131 90483150
Hypomagnesaemia 17.39 13.91 107 145059 35481 90447800
Polyneuropathy chronic 17.37 13.91 4 145162 8 90483273
Cholangiectasis acquired 17.37 13.91 4 145162 8 90483273
Hypophosphatasia 17.36 13.91 6 145160 72 90483209
Eye swelling 17.35 13.91 13 145153 29373 90453908
Muscular weakness 17.32 13.91 230 144936 206436 90276845
Tumour haemorrhage 17.31 13.91 19 145147 2075 90481206
Alopecia totalis 17.27 13.91 10 145156 428 90482853
SAPHO syndrome 17.26 13.91 7 145159 134 90483147
Varicose vein 17.22 13.91 37 145129 7290 90475991
Hypoglycaemia 17.14 13.91 56 145110 69792 90413489
Skin disorder 17.09 13.91 109 145057 36597 90446684
Respiratory failure 16.85 13.91 275 144891 118143 90365138
Insomnia 16.83 13.91 406 144760 333068 90150213
Radical mastectomy 16.76 13.91 4 145162 10 90483271
Duodenal ulcer 16.74 13.91 43 145123 9509 90473772
Gait apraxia 16.73 13.91 5 145161 36 90483245
Blood glucose increased 16.71 13.91 87 145079 95159 90388122
Leukaemia cutis 16.67 13.91 7 145159 147 90483134
Scintillating scotoma 16.58 13.91 7 145159 149 90483132
Pneumonia aspiration 16.47 13.91 25 145141 40915 90442366
Dacryostenosis acquired 16.41 13.91 12 145154 767 90482514
Neuromyopathy 16.38 13.91 12 145154 769 90482512
Mental status changes 16.38 13.91 29 145137 44650 90438631
Inflammatory carcinoma of breast stage IV 16.32 13.91 3 145163 0 90483281
Multiple gated acquisition scan abnormal 16.32 13.91 3 145163 0 90483281
Globulinuria 16.32 13.91 3 145163 0 90483281
Simple mastectomy 16.32 13.91 3 145163 0 90483281
Metastases to the respiratory system 16.32 13.91 3 145163 0 90483281
Creatinine renal clearance decreased 16.27 13.91 5 145161 18894 90464387
Blood bilirubin decreased 16.23 13.91 13 145153 952 90482329
Mouth swelling 16.17 13.91 31 145135 5631 90477650
Pneumocystis test positive 16.16 13.91 5 145161 41 90483240
Hallucination, auditory 16.16 13.91 3 145163 15972 90467309
Spinal stenosis 16.14 13.91 4 145162 17420 90465861
Vertigo 16.12 13.91 177 144989 69634 90413647
Lip swelling 16.10 13.91 23 145143 38587 90444694
Pain in extremity 16.10 13.91 575 144591 449954 90033327
Musculoskeletal chest pain 16.05 13.91 78 145088 23672 90459609
Acral peeling skin syndrome 15.99 13.91 4 145162 13 90483268
Tooth development disorder 15.95 13.91 5 145161 43 90483238
Flatulence 15.94 13.91 26 145140 41341 90441940
Nail bed tenderness 15.90 13.91 9 145157 369 90482912
Obstructive airways disorder 15.85 13.91 11 145155 25858 90457423
Disorientation 15.84 13.91 29 145137 44085 90439196
Respiratory arrest 15.80 13.91 18 145148 33293 90449988
Pancreatitis 15.77 13.91 58 145108 69768 90413513
Chest wall abscess 15.73 13.91 6 145160 97 90483184
Spider naevus 15.65 13.91 7 145159 172 90483109
Rhinorrhoea 15.65 13.91 213 144953 88103 90395178
Joint effusion 15.61 13.91 6 145160 19704 90463577
Liver disorder 15.52 13.91 122 145044 121147 90362134
Hepatic cancer recurrent 15.43 13.91 7 145159 178 90483103
Pustule 15.43 13.91 21 145145 2862 90480419
Immune-mediated adverse reaction 15.32 13.91 12 145154 851 90482430
Ulcerative keratitis 15.31 13.91 23 145143 3430 90479851
Premature delivery 15.28 13.91 24 145142 38738 90444543
Clostridial infection 15.28 13.91 27 145139 4609 90478672
Adverse reaction 15.28 13.91 15 145151 29697 90453584
Colitis ischaemic 15.24 13.91 49 145117 12297 90470984
Therapeutic response unexpected 15.23 13.91 8 145158 21872 90461409
Left atrial enlargement 15.20 13.91 11 145155 692 90482589
Visual acuity reduced 15.19 13.91 76 145090 23334 90459947
Nasal ulcer 15.15 13.91 20 145146 2646 90480635
Dandy-Walker syndrome 15.14 13.91 6 145160 108 90483173
Paraparesis 15.12 13.91 21 145145 2917 90480364
Central nervous system infection 15.10 13.91 12 145154 869 90482412
Accidental exposure to product 15.08 13.91 28 145138 42338 90440943
Viral infection 15.07 13.91 27 145139 41387 90441894
Incorrect route of product administration 15.07 13.91 37 145129 50589 90432692
Bradycardia 15.04 13.91 76 145090 83771 90399510
Cancer fatigue 15.01 13.91 7 145159 190 90483091
Intracranial mass 14.99 13.91 14 145152 1261 90482020
Appendiceal abscess 14.98 13.91 8 145158 292 90482989
Gastrointestinal haemorrhage 14.97 13.91 84 145082 90164 90393117
Drug tolerance 14.96 13.91 5 145161 17911 90465370
Malaise 14.88 13.91 777 144389 585209 89898072
Mydriasis 14.80 13.91 3 145163 15009 90468272
Left ventricular failure 14.80 13.91 33 145133 6667 90476614
Neutropenic colitis 14.80 13.91 25 145141 4118 90479163
Thyroid disorder 14.79 13.91 5 145161 17780 90465501
Periodontitis 14.77 13.91 24 145142 3829 90479452
Vaginal prolapse 14.74 13.91 10 145156 567 90482714
Unwanted pregnancy 14.65 13.91 6 145160 118 90483163
Lymph node fibrosis 14.62 13.91 4 145162 20 90483261
Metastases to eye 14.62 13.91 7 145159 202 90483079
Naevus haemorrhage 14.60 13.91 6 145160 119 90483162
Essential thrombocythaemia 14.59 13.91 7 145159 203 90483078
Gastrointestinal candidiasis 14.57 13.91 8 145158 309 90482972
Cardio-respiratory arrest 14.55 13.91 52 145114 63088 90420193
Eye pruritus 14.53 13.91 15 145151 29012 90454269
Corneal bleeding 14.46 13.91 4 145162 21 90483260
Urogenital prolapse 14.46 13.91 4 145162 21 90483260
Eyelid oedema 14.44 13.91 46 145120 11488 90471793
Lymphoid tissue hyperplasia 14.43 13.91 7 145159 208 90483073
Nasal crusting 14.35 13.91 9 145157 446 90482835
Bundle branch block left 14.34 13.91 36 145130 7849 90475432
Neuralgia 14.33 13.91 93 145073 31407 90451874
Vagus nerve disorder 14.33 13.91 6 145160 125 90483156
Post procedural pneumonia 14.31 13.91 5 145161 62 90483219
Paroxysmal arrhythmia 14.31 13.91 5 145161 62 90483219
Vena cava thrombosis 14.28 13.91 19 145147 2533 90480748
Rash follicular 14.24 13.91 5 145161 63 90483218
Merycism 14.24 13.91 8 145158 323 90482958
Urinary tract injury 14.24 13.91 3 145163 3 90483278
Ligament sprain 14.23 13.91 3 145163 14596 90468685
Bone density decreased 14.21 13.91 5 145161 17340 90465941
Macular oedema 14.17 13.91 27 145139 4882 90478399
Pruritus 14.14 13.91 716 144450 540809 89942472
Device malfunction 14.12 13.91 8 145158 20969 90462312
Echocardiogram abnormal 14.08 13.91 15 145151 1584 90481697
Infusion site pain 14.06 13.91 7 145159 19731 90463550
Radiculopathy 14.06 13.91 6 145160 18499 90464782
Visual impairment 13.93 13.91 140 145026 132225 90351056

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 502.99 22.34 367 11082 143289 42466597
Myelosuppression 457.52 22.34 221 11228 40240 42569646
Off label use 361.39 22.34 623 10826 637712 41972174
Delusion of grandeur 191.12 22.34 53 11396 1943 42607943
Rhinalgia 172.13 22.34 48 11401 1796 42608090
Lymphocyte count abnormal 155.26 22.34 46 11403 2141 42607745
Affective disorder 144.80 22.34 56 11393 5904 42603982
Palmar-plantar erythrodysaesthesia syndrome 126.30 22.34 75 11374 20507 42589379
Neuropathy peripheral 119.78 22.34 142 11307 101711 42508175
Schizophrenia 114.04 22.34 56 11393 10494 42599392
Metastases to central nervous system 106.10 22.34 53 11396 10302 42599584
Gastrointestinal anastomotic leak 101.33 22.34 25 11424 574 42609312
SARS-CoV-2 test positive 98.81 22.34 47 11402 8213 42601673
Mucosal inflammation 97.78 22.34 91 11358 49283 42560603
Therapy partial responder 97.55 22.34 63 11386 19958 42589928
Extrapyramidal disorder 95.99 22.34 58 11391 16354 42593532
Oligohydramnios 94.94 22.34 22 11427 383 42609503
Alopecia 93.27 22.34 71 11378 29205 42580681
Hallucination, auditory 88.15 22.34 53 11396 14811 42595075
Diarrhoea 86.26 22.34 295 11154 460554 42149332
Neutrophil count increased 81.25 22.34 56 11393 19748 42590138
Chills 75.91 22.34 109 11340 93957 42515929
Lymphocyte count decreased 70.52 22.34 59 11390 27750 42582136
Metastases to liver 68.94 22.34 47 11402 16279 42593607
Leukopenia 68.34 22.34 92 11357 74654 42535232
Pulmonary hypoplasia 64.98 22.34 17 11432 497 42609389
Psychotic disorder 62.01 22.34 56 11393 29152 42580734
Gastric stenosis 57.14 22.34 12 11437 129 42609757
Neoplasm progression 56.50 22.34 53 11396 28947 42580939
Condition aggravated 54.78 22.34 4 11445 260750 42349136
Nose deformity 54.73 22.34 13 11436 253 42609633
Malignant neoplasm progression 53.96 22.34 101 11348 108299 42501587
Death 52.35 22.34 257 11192 470928 42138958
Ear malformation 51.11 22.34 13 11436 339 42609547
No adverse event 50.10 22.34 57 11392 38964 42570922
Incorrect dose administered 49.61 22.34 66 11383 52908 42556978
Platelet count decreased 48.84 22.34 112 11337 138469 42471417
Anastomotic complication 47.83 22.34 13 11436 441 42609445
Neutrophil count decreased 47.51 22.34 71 11378 63344 42546542
Neutropenia 46.47 22.34 138 11311 199293 42410593
Carbohydrate antigen 15-3 increased 45.59 22.34 9 11440 69 42609817
Cardiotoxicity 45.30 22.34 27 11422 7418 42602468
Anastomotic leak 45.15 22.34 14 11435 760 42609126
Tidal volume decreased 44.34 22.34 8 11441 35 42609851
Ejection fraction decreased 44.24 22.34 41 11408 22046 42587840
Hypertelorism 43.84 22.34 13 11436 606 42609280
Product use in unapproved indication 43.30 22.34 128 11321 184328 42425558
Interstitial lung disease 42.68 22.34 76 11373 78386 42531500
Metastases to lung 41.50 22.34 30 11419 11394 42598492
Dyspepsia 41.00 22.34 53 11396 41299 42568587
Bone marrow failure 40.22 22.34 47 11402 33046 42576840
Adenocarcinoma metastatic 38.53 22.34 8 11441 81 42609805
Gastrointestinal stenosis 38.34 22.34 9 11440 166 42609720
Onycholysis 37.64 22.34 13 11436 992 42608894
Drug interaction 36.67 22.34 13 11436 266986 42342900
Cellulitis 36.55 22.34 62 11387 61523 42548363
Abdominal infection 35.30 22.34 16 11433 2503 42607383
Polydactyly 35.04 22.34 13 11436 1221 42608665
Fall 34.72 22.34 10 11439 234510 42375376
Foetal growth abnormality 33.12 22.34 6 11443 27 42609859
Gastric perforation 32.17 22.34 16 11433 3077 42606809
Infusion related reaction 30.65 22.34 57 11392 60749 42549137
Hyperpyrexia 30.13 22.34 16 11433 3524 42606362
Metastases to bone 28.71 22.34 27 11422 14782 42595104
Liver ablation 28.28 22.34 5 11444 19 42609867
Abortion induced 27.95 22.34 7 11442 171 42609715
Autoimmune hypothyroidism 27.32 22.34 7 11442 188 42609698
Brain neoplasm 27.23 22.34 15 11434 3553 42606333
Breast cancer metastatic 26.60 22.34 6 11443 92 42609794
Headache 26.15 22.34 16 11433 239353 42370533
Renal hypoplasia 25.86 22.34 6 11443 105 42609781
Obstruction gastric 25.80 22.34 10 11439 1058 42608828
Rectal polyp 25.71 22.34 9 11440 715 42609171
PIK3CA-activated mutation 24.92 22.34 6 11443 124 42609762
Paranasal sinus discomfort 24.70 22.34 10 11439 1187 42608699
Foetal exposure during pregnancy 24.65 22.34 45 11404 47266 42562620
Nausea 24.43 22.34 186 11263 396613 42213273
Foetal growth restriction 24.19 22.34 16 11433 5267 42604619
Pancytopenia 24.13 22.34 78 11371 117665 42492221
Dizziness 24.12 22.34 19 11430 249235 42360651
Intentional product use issue 24.10 22.34 57 11392 71776 42538110
Hepatic lesion 24.01 22.34 15 11434 4479 42605407
Product dose omission issue 23.92 22.34 6 11443 154359 42455527
Nail toxicity 23.87 22.34 5 11444 53 42609833
Polyneuropathy 23.50 22.34 27 11422 18634 42591252
Confusional state 23.26 22.34 8 11441 167589 42442297
Drug effective for unapproved indication 23.14 22.34 17 11432 6616 42603270
Metastases to meninges 22.96 22.34 11 11438 1950 42607936
Dysmorphism 22.75 22.34 13 11436 3303 42606583
Stomatitis 22.68 22.34 45 11404 50284 42559602
Metastases to lymph nodes 22.35 22.34 16 11433 5982 42603904

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 5881.59 14.21 2606 121088 91734 110373871
Ejection fraction decreased 2287.29 14.21 1049 122645 39831 110425774
Metastases to central nervous system 1546.62 14.21 670 123024 22147 110443458
Disease progression 1454.80 14.21 1569 122125 242465 110223140
Diarrhoea 1423.22 14.21 3589 120105 1135916 109329689
Palmar-plantar erythrodysaesthesia syndrome 1168.44 14.21 668 123026 40357 110425248
Cardiotoxicity 927.32 14.21 428 123266 16453 110449152
Neuropathy peripheral 906.86 14.21 1059 122635 178218 110287387
Chills 748.99 14.21 992 122702 189588 110276017
Metastases to bone 601.76 14.21 397 123297 30975 110434630
Metastases to liver 586.32 14.21 409 123285 34977 110430628
Polyneuropathy 546.79 14.21 377 123317 31635 110433970
Metastases to lung 542.41 14.21 332 123362 22731 110442874
Neutropenia 499.01 14.21 1214 122480 373406 110092199
Drug ineffective 493.28 14.21 588 123106 1519952 108945653
Mucosal inflammation 479.07 14.21 564 123130 95577 110370028
Cardiac dysfunction 478.73 14.21 200 123494 6023 110459582
Bone marrow failure 472.58 14.21 442 123252 57406 110408199
Metastases to lymph nodes 412.39 14.21 239 123455 14793 110450812
Left ventricular dysfunction 404.32 14.21 278 123416 23215 110442390
Malignant neoplasm progression 387.48 14.21 698 122996 173869 110291736
Breast cancer metastatic 386.61 14.21 207 123487 10974 110454631
Febrile neutropenia 374.99 14.21 982 122712 315785 110149820
Nausea 355.79 14.21 2478 121216 1233212 109232393
Neoplasm progression 346.98 14.21 394 123300 64201 110401404
Breast cancer recurrent 334.62 14.21 135 123559 3711 110461894
Interstitial lung disease 307.67 14.21 556 123138 138778 110326827
Hyperpyrexia 294.84 14.21 155 123539 7914 110457691
Rheumatoid arthritis 293.99 14.21 9 123685 299604 110166001
Synovitis 285.59 14.21 4 123690 274088 110191517
Condition aggravated 284.16 14.21 243 123451 734593 109731012
Joint swelling 283.27 14.21 73 123621 442772 110022833
Cardiomyopathy 267.69 14.21 253 123441 33272 110432333
Drug hypersensitivity 262.87 14.21 90 123604 454000 110011605
Hepatic function abnormal 260.83 14.21 404 123290 88891 110376714
Cardiac failure 257.84 14.21 616 123078 187010 110278595
Lymphoedema 255.31 14.21 176 123518 14753 110450852
Neutrophil count decreased 253.59 14.21 472 123222 120469 110345136
White blood cell count decreased 248.95 14.21 689 123005 228701 110236904
Metastases to skin 246.90 14.21 94 123600 2205 110463400
Systemic lupus erythematosus 238.00 14.21 11 123683 254327 110211278
Drug interaction 229.02 14.21 138 123556 500045 109965560
Contraindicated product administered 228.27 14.21 12 123682 248255 110217350
Osteonecrosis of jaw 223.15 14.21 272 123422 47745 110417860
Fall 216.03 14.21 214 123480 603268 109862337
Arthropathy 213.80 14.21 33 123661 287489 110178116
Confusional state 209.42 14.21 133 123561 468547 109997058
Pneumonitis 207.94 14.21 335 123359 76196 110389409
Peripheral sensory neuropathy 204.73 14.21 161 123533 16519 110449086
Epistaxis 204.42 14.21 451 123243 129921 110335684
Neutropenic sepsis 199.07 14.21 207 123487 30539 110435066
Computerised tomogram thorax abnormal 198.89 14.21 85 123609 2710 110462895
Therapeutic product effect decreased 196.10 14.21 22 123672 244294 110221311
Hypokalaemia 193.93 14.21 544 123150 181904 110283701
Pleural effusion 192.95 14.21 534 123160 177175 110288430
Granulocyte count decreased 188.21 14.21 91 123603 3883 110461722
Drug abuse 183.01 14.21 3 123691 177408 110288197
Abdominal discomfort 182.56 14.21 107 123587 393751 110071854
Pyrexia 179.47 14.21 1659 122035 896606 109568999
Onycholysis 179.18 14.21 79 123615 2720 110462885
Paronychia 174.02 14.21 124 123570 10957 110454648
Metastasis 171.67 14.21 110 123584 8157 110457448
Vomiting 170.03 14.21 1658 122036 909017 109556588
Vascular device infection 168.22 14.21 143 123551 16369 110449236
Fibromyalgia 168.08 14.21 5 123689 170904 110294701
Metastases to meninges 166.30 14.21 91 123603 5037 110460568
Platelet count decreased 161.81 14.21 596 123098 229847 110235758
Ventricular dysfunction 161.09 14.21 102 123592 7409 110458196
Recall phenomenon 160.50 14.21 60 123634 1336 110464269
Duodenal ulcer perforation 159.01 14.21 10 123684 177690 110287915
Product dose omission issue 156.94 14.21 82 123612 321700 110143905
Weight increased 148.67 14.21 150 123544 419494 110046111
Anaemia 146.38 14.21 1080 122614 546006 109919599
Mobility decreased 146.30 14.21 42 123652 237380 110228225
Nail toxicity 146.21 14.21 42 123652 388 110465217
Bone pain 145.06 14.21 261 123433 64872 110400733
Injury 144.68 14.21 15 123679 177250 110288355
Leukopenia 142.99 14.21 428 123266 148363 110317242
Sinusitis 141.17 14.21 78 123616 296610 110168995
Treatment failure 136.14 14.21 70 123624 277164 110188441
Glossodynia 135.46 14.21 40 123654 221964 110243641
Wheezing 133.66 14.21 59 123635 255171 110210434
Wound 132.90 14.21 48 123646 234389 110231216
Hyperbilirubinaemia 126.96 14.21 164 123530 30507 110435098
Fatigue 126.03 14.21 1982 121712 1213976 109251629
Off label use 125.52 14.21 2362 121332 1497823 108967782
Lymphangiosis carcinomatosa 124.12 14.21 59 123635 2423 110463182
Toxicity to various agents 124.09 14.21 217 123477 480338 109985267
Swelling 123.71 14.21 126 123568 350915 110114690
Psoriasis 121.96 14.21 9 123685 139984 110325621
Asthma 121.69 14.21 64 123630 250227 110215378
Irritable bowel syndrome 119.43 14.21 20 123674 164195 110301410
Oligohydramnios 118.91 14.21 67 123627 3927 110461678
Blood cholesterol increased 118.91 14.21 30 123664 184755 110280850
Pain 118.38 14.21 608 123086 954347 109511258
Joint range of motion decreased 118.23 14.21 4 123690 121828 110343777
Pericarditis 117.36 14.21 49 123645 219065 110246540
Nail dystrophy 116.90 14.21 46 123648 1182 110464423
Cellulitis 116.84 14.21 358 123336 125658 110339947
Loss of personal independence in daily activities 116.67 14.21 15 123679 150005 110315600
Folliculitis 114.29 14.21 24 123670 167629 110297976
Bursitis 114.19 14.21 8 123686 129910 110335695
Dysgeusia 114.08 14.21 246 123448 69739 110395866
Skin toxicity 113.84 14.21 99 123595 11684 110453921
Biopsy lung abnormal 112.80 14.21 28 123666 137 110465468
Inappropriate schedule of product administration 109.93 14.21 45 123649 203592 110262013
Impaired healing 108.60 14.21 42 123652 196675 110268930
Musculoskeletal stiffness 108.54 14.21 92 123602 279730 110185875
Invasive ductal breast carcinoma 108.13 14.21 76 123618 6570 110459035
Delusion of grandeur 107.78 14.21 52 123642 2208 110463397
Mitral valve incompetence 107.52 14.21 158 123536 33171 110432434
Alveolitis 107.16 14.21 65 123629 4374 110461231
Neurotoxicity 105.52 14.21 178 123516 42029 110423576
Asthenia 105.06 14.21 1205 122489 687794 109777811
Computerised tomogram thorax 104.53 14.21 34 123660 492 110465113
Erysipelas 104.45 14.21 99 123595 13059 110452546
Gastrointestinal toxicity 104.36 14.21 92 123602 11056 110454549
Osteoarthritis 104.16 14.21 37 123657 182586 110283019
Type 2 diabetes mellitus 100.93 14.21 36 123658 177196 110288409
Chest discomfort 98.86 14.21 421 123273 173427 110292178
Mastitis 98.78 14.21 51 123643 2507 110463098
Ventricular hypokinesia 97.96 14.21 89 123605 11125 110454480
Metastatic neoplasm 97.51 14.21 68 123626 5805 110459800
Drug intolerance 97.44 14.21 192 123502 406320 110059285
Thrombocytopenia 96.75 14.21 695 122999 348190 110117415
Haematotoxicity 95.63 14.21 118 123576 20964 110444641
Radiation skin injury 94.69 14.21 43 123651 1589 110464016
Lacrimation increased 93.09 14.21 142 123552 30808 110434797
Temperature intolerance 92.24 14.21 95 123599 13855 110451750
Hepatic enzyme increased 92.12 14.21 135 123559 320757 110144848
Discomfort 91.64 14.21 64 123630 214643 110250962
Metastases to spine 91.38 14.21 63 123631 5280 110460325
Therapy partial responder 90.93 14.21 155 123539 36906 110428699
Somnolence 90.51 14.21 120 123574 297329 110168276
Dermatitis acneiform 90.42 14.21 90 123604 12605 110453000
Contusion 90.15 14.21 77 123617 233284 110232321
Blister 87.87 14.21 75 123619 227301 110238304
Decreased appetite 87.28 14.21 864 122830 474982 109990623
Nail discolouration 87.16 14.21 53 123641 3582 110462023
Therapeutic product effect incomplete 86.27 14.21 74 123620 223731 110241874
Road traffic accident 85.31 14.21 10 123684 107388 110358217
HER2 positive breast cancer 84.62 14.21 27 123667 366 110465239
Lymphocyte count abnormal 84.10 14.21 45 123649 2381 110463224
Suicide attempt 83.71 14.21 9 123685 103385 110362220
Migraine 83.26 14.21 44 123650 171608 110293997
Dyspnoea 83.19 14.21 1716 121978 1105156 109360449
Stomatitis 82.96 14.21 552 123142 269690 110195915
Gait inability 82.39 14.21 25 123669 136351 110329254
Hypercholesterolaemia 81.58 14.21 5 123689 90832 110374773
Urticaria 81.32 14.21 145 123549 318712 110146893
Pericardial effusion 80.82 14.21 190 123504 57027 110408578
Peripheral venous disease 80.78 14.21 3 123691 84114 110381491
Onychoclasis 80.61 14.21 66 123628 7171 110458434
Skin fissures 80.42 14.21 117 123577 24341 110441264
Congestive cardiomyopathy 80.19 14.21 89 123605 14130 110451475
Arthralgia 79.59 14.21 528 123166 779104 109686501
Drug reaction with eosinophilia and systemic symptoms 78.59 14.21 3 123691 82092 110383513
Depression 77.65 14.21 148 123546 317187 110148418
Aortitis 77.31 14.21 40 123654 1975 110463630
Madarosis 76.70 14.21 48 123646 3415 110462190
Hot flush 76.17 14.21 203 123491 65833 110399772
Rhinalgia 75.99 14.21 50 123644 3879 110461726
Delirium 75.90 14.21 28 123666 134997 110330608
Arthritis 75.51 14.21 47 123647 167539 110298066
Multifocal micronodular pneumocyte hyperplasia 75.26 14.21 18 123676 73 110465532
Sleep disorder 74.96 14.21 67 123627 198577 110267028
Recurrent cancer 74.70 14.21 47 123647 3376 110462229
Hospitalisation 74.48 14.21 33 123661 142460 110323145
Bronchial polyp 73.75 14.21 18 123676 81 110465524
Cough 73.68 14.21 815 122879 460826 110004779
Tumour marker increased 73.47 14.21 54 123640 5006 110460599
Atelectasis 72.82 14.21 140 123554 36572 110429033
Hypertransaminasaemia 72.55 14.21 111 123583 24144 110441461
Maternal exposure during pregnancy 72.38 14.21 108 123586 254775 110210830
Hepatotoxicity 72.22 14.21 194 123500 63206 110402399
Product use issue 71.44 14.21 151 123543 311544 110154061
Breast pain 71.42 14.21 71 123623 9929 110455676
Vulvovaginal dryness 70.92 14.21 42 123652 2705 110462900
Lactic acidosis 70.45 14.21 10 123684 92801 110372804
Overdose 70.42 14.21 95 123599 233699 110231906
Rhabdomyolysis 69.32 14.21 24 123670 120377 110345228
Acute myeloid leukaemia 67.96 14.21 139 123555 37971 110427634
Carcinoembryonic antigen increased 67.27 14.21 41 123653 2783 110462822
Myalgia 66.88 14.21 452 123242 221929 110243676
Mastectomy 66.76 14.21 33 123661 1478 110464127
Colitis 66.24 14.21 258 123436 102065 110363540
Osteonecrosis 66.10 14.21 128 123566 33613 110431992
Injection site pain 65.95 14.21 61 123633 177861 110287744
Breast neoplasm 64.96 14.21 29 123665 1029 110464576
Exposure during pregnancy 64.95 14.21 55 123639 167369 110298236
Medication error 64.22 14.21 19 123675 105347 110360258
Device related infection 63.35 14.21 138 123556 39381 110426224
Hyperkalaemia 62.69 14.21 37 123657 135759 110329846
Metastases to pleura 62.48 14.21 35 123659 2028 110463577
Anxiety 62.18 14.21 189 123505 344889 110120716
Second primary malignancy 61.69 14.21 88 123606 17980 110447625
Inflammation 60.78 14.21 76 123618 193162 110272443
Alopecia areata 60.58 14.21 35 123659 2152 110463453
Nail bed inflammation 60.29 14.21 34 123660 1996 110463609
Injection site reaction 60.18 14.21 13 123681 89057 110376548
Gastrointestinal anastomotic leak 60.16 14.21 25 123669 742 110464863
Knee arthroplasty 60.10 14.21 3 123691 64945 110400660
Agranulocytosis 59.61 14.21 178 123516 61582 110404023
Transaminases increased 59.59 14.21 181 123513 63209 110402396
Acute interstitial pneumonitis 59.23 14.21 30 123664 1416 110464189
Sedation 59.23 14.21 5 123689 69678 110395927
Product use in unapproved indication 58.02 14.21 280 123414 447097 110018508
Peripheral swelling 57.09 14.21 245 123449 403789 110061816
Onychalgia 56.77 14.21 27 123667 1110 110464495
Microvascular coronary artery disease 56.26 14.21 20 123674 384 110465221
Stress cardiomyopathy 55.47 14.21 78 123616 15728 110449877
Lymphocyte count decreased 55.27 14.21 165 123529 57078 110408527
Product quality issue 54.91 14.21 10 123684 77289 110388316
Ear infection 54.73 14.21 4 123690 62728 110402877
Infection 54.69 14.21 214 123480 361986 110103619
Night sweats 54.48 14.21 42 123652 133941 110331664
Flushing 54.47 14.21 247 123447 104489 110361116
Breast cancer 54.44 14.21 128 123566 38414 110427191
Sciatica 53.92 14.21 18 123676 92381 110373224
Disease recurrence 53.83 14.21 170 123524 60614 110404991
Alopecia 53.68 14.21 634 123060 364119 110101486
Blood bilirubin increased 53.67 14.21 197 123497 75775 110389830
Chronic obstructive pulmonary disease 52.90 14.21 28 123666 109130 110356475
Adverse event 52.60 14.21 28 123666 108781 110356824
Sarcoid-like reaction 52.55 14.21 18 123676 308 110465297
Pseudocirrhosis 52.54 14.21 24 123670 899 110464706
Hair texture abnormal 52.51 14.21 40 123654 3914 110461691
Hallucination 50.67 14.21 25 123669 101407 110364198
Dehydration 50.43 14.21 506 123188 279005 110186600
Drug ineffective for unapproved indication 50.39 14.21 26 123668 102812 110362793
Axillary pain 50.23 14.21 33 123661 2553 110463052
Tonsillar disorder 49.88 14.21 27 123667 1462 110464143
Metastases to chest wall 49.56 14.21 21 123673 655 110464950
Orthostatic hypotension 48.31 14.21 8 123686 66241 110399364
Organising pneumonia 48.09 14.21 69 123625 14174 110451431
Lymphadenopathy 48.05 14.21 169 123525 63666 110401939
Feeling abnormal 48.04 14.21 80 123614 180631 110284974
Radiation necrosis 47.97 14.21 22 123672 832 110464773
Neutropenic infection 47.95 14.21 35 123659 3210 110462395
Central nervous system lesion 47.68 14.21 72 123622 15481 110450124
Lung disorder 47.59 14.21 80 123614 179967 110285638
Therapy non-responder 47.28 14.21 64 123630 157243 110308362
Hydrothorax 47.17 14.21 27 123667 1631 110463974
International normalised ratio increased 47.09 14.21 19 123675 86753 110378852
Nasal mucosal disorder 46.56 14.21 28 123666 1855 110463750
Blepharospasm 46.44 14.21 4 123690 54847 110410758
Hair colour changes 46.43 14.21 40 123654 4661 110460944
Bone lesion 46.38 14.21 48 123646 7039 110458566
Aspartate aminotransferase increased 46.24 14.21 322 123372 159614 110305991
Blood creatinine decreased 46.12 14.21 54 123640 9083 110456522
Breast disorder 46.10 14.21 30 123664 2284 110463321
Cytomegalovirus infection 46.02 14.21 4 123690 54440 110411165
Breast mass 45.98 14.21 51 123643 8090 110457515
Injection site erythema 45.86 14.21 24 123670 94152 110371453
Neutrophil count increased 45.63 14.21 112 123582 34540 110431065
Sensory disturbance 45.56 14.21 75 123619 17354 110448251
Frequent bowel movements 45.13 14.21 12 123682 71378 110394227
Prescribed underdose 45.09 14.21 9 123685 65165 110400440
Nasal congestion 45.05 14.21 27 123667 98255 110367350
Blood lactate dehydrogenase increased 44.91 14.21 130 123564 44204 110421401
Blood uric acid decreased 44.33 14.21 25 123669 1468 110464137
Adverse drug reaction 44.32 14.21 32 123662 105527 110360078
Obesity 44.25 14.21 37 123657 113314 110352291
Hepatic lesion 44.22 14.21 51 123643 8442 110457163
Tumour pain 43.84 14.21 32 123662 2935 110462670
Streptococcal sepsis 43.80 14.21 40 123654 5032 110460573
Osteosclerosis 43.75 14.21 38 123656 4477 110461128
Back pain 43.68 14.21 619 123075 370377 110095228
Alanine aminotransferase increased 43.53 14.21 353 123341 183420 110282185
Wound infection 43.52 14.21 27 123667 96438 110369167
Gait disturbance 43.52 14.21 162 123532 278046 110187559
Hepatic failure 43.41 14.21 172 123522 68567 110397038
Accidental overdose 43.29 14.21 4 123690 51830 110413775
Electrocardiogram QT prolonged 43.24 14.21 35 123659 108925 110356680
Dihydropyrimidine dehydrogenase deficiency 43.08 14.21 14 123680 202 110465403
Memory impairment 42.97 14.21 98 123596 196846 110268759
Gastric stenosis 42.95 14.21 14 123680 204 110465401
Plasma cell myeloma 42.90 14.21 9 123685 62927 110402678
Metastases to breast 42.68 14.21 16 123678 359 110465246
Eosinophilia 42.24 14.21 7 123687 57929 110407676
Bradycardia 42.12 14.21 68 123626 155449 110310156
Erythema 41.72 14.21 504 123190 290943 110174662
Meibomian gland dysfunction 41.48 14.21 15 123679 303 110465302
Suicidal ideation 41.41 14.21 27 123667 93910 110371695
Keratitis 41.39 14.21 39 123655 5105 110460500
Papilloedema 41.14 14.21 46 123648 7363 110458242
Acute respiratory distress syndrome 41.04 14.21 142 123552 53056 110412549
Cystoid macular oedema 40.92 14.21 30 123664 2770 110462835
Gastrointestinal haemorrhage 40.63 14.21 77 123617 165441 110300164
Dermatomyositis 40.52 14.21 36 123658 4370 110461235
Cardio-respiratory arrest 40.28 14.21 42 123652 115794 110349811
Carbohydrate antigen 15-3 increased 40.28 14.21 24 123670 1563 110464042
Affective disorder 40.23 14.21 56 123638 11185 110454420
Toxic cardiomyopathy 40.20 14.21 19 123675 770 110464835
Injection site pruritus 40.15 14.21 5 123689 51253 110414352
Exostosis 39.89 14.21 3 123691 45953 110419652
Foot deformity 39.81 14.21 4 123690 48476 110417129
Unresponsive to stimuli 39.80 14.21 11 123683 63779 110401826
Pulmonary mass 39.36 14.21 111 123583 37190 110428415
Diabetes mellitus 39.34 14.21 32 123662 99349 110366256
Osteoporosis 38.48 14.21 25 123669 87127 110378478
Subclavian vein thrombosis 38.39 14.21 29 123665 2803 110462802
Intentional product misuse 38.02 14.21 56 123638 132848 110332757
Bone erosion 37.63 14.21 4 123690 46367 110419238
Blepharitis 37.57 14.21 35 123659 4517 110461088
Death 37.48 14.21 1035 122659 697834 109767771
Blood alkaline phosphatase increased 37.41 14.21 168 123526 70767 110394838
Nail infection 37.14 14.21 27 123667 2461 110463144
Constipation 36.68 14.21 583 123111 357203 110108402
Swollen tongue 36.57 14.21 11 123683 60351 110405254
Acute kidney injury 36.50 14.21 496 123198 634934 109830671
Back injury 36.22 14.21 5 123689 47394 110418211
Musculoskeletal pain 36.06 14.21 96 123598 182927 110282678
Cystitis noninfective 36.02 14.21 23 123671 1695 110463910
Hemianopia 35.88 14.21 28 123666 2840 110462765
Dyskinesia 35.81 14.21 7 123687 51439 110414166
Hypoglycaemia 35.12 14.21 47 123647 116057 110349548
Treatment noncompliance 34.96 14.21 19 123675 72971 110392634
Pleural disorder 34.91 14.21 19 123675 1040 110464565
Adenocarcinoma metastatic 34.66 14.21 14 123680 386 110465219
Systolic dysfunction 34.63 14.21 33 123661 4382 110461223
Nodular regenerative hyperplasia 34.60 14.21 22 123672 1609 110463996
Acoustic stimulation tests abnormal 34.60 14.21 8 123686 27 110465578
Sense of oppression 34.39 14.21 22 123672 1626 110463979
Cardiac failure chronic 34.19 14.21 58 123636 13753 110451852
Enterocolitis 33.65 14.21 69 123625 18880 110446725
Depressed level of consciousness 33.41 14.21 46 123648 112232 110353373
Enterocolitis infectious 33.40 14.21 29 123665 3415 110462190
Hyperfibrinogenaemia 33.39 14.21 11 123683 166 110465439
Mental status changes 33.39 14.21 22 123672 76100 110389505
Odynophagia 33.31 14.21 58 123636 14043 110451562
Mouth ulceration 33.31 14.21 124 123570 48014 110417591
Central vision loss 33.28 14.21 9 123685 65 110465540
Paraesthesia 33.18 14.21 463 123231 276058 110189547
Illness 33.10 14.21 26 123668 82145 110383460
Colitis ulcerative 33.07 14.21 23 123671 77340 110388265
Dry skin 33.05 14.21 220 123474 107433 110358172
Ejection fraction 33.02 14.21 27 123667 2928 110462677
Gamma-glutamyltransferase increased 32.93 14.21 146 123548 61163 110404442
Eosinophil percentage increased 32.72 14.21 21 123673 1561 110464044
Cystitis haemorrhagic 32.54 14.21 53 123641 12156 110453449
Dermatitis 32.52 14.21 86 123608 27751 110437854
Dislocation of vertebra 32.51 14.21 5 123689 43716 110421889
Aortic valve incompetence 32.48 14.21 50 123644 10931 110454674
Pancreatitis 32.42 14.21 34 123660 93499 110372106
Wrong technique in product usage process 32.30 14.21 30 123664 87318 110378287
Left ventricular dilatation 32.23 14.21 20 123674 1402 110464203
Neoplasm 32.12 14.21 50 123644 11037 110454568
Feeling cold 31.89 14.21 97 123597 33890 110431715
Product prescribing error 31.75 14.21 9 123685 51322 110414283
Neoplasm recurrence 31.68 14.21 34 123660 5198 110460407
Cardiac ventricular thrombosis 31.53 14.21 27 123667 3120 110462485
Autoimmune hypothyroidism 31.35 14.21 14 123680 497 110465108
Red cell distribution width increased 31.14 14.21 64 123630 17538 110448067
Bladder irritation 31.09 14.21 13 123681 392 110465213
Eastern Cooperative Oncology Group performance status worsened 30.83 14.21 26 123668 2943 110462662
Lung infiltration 30.74 14.21 78 123616 24550 110441055
Coma 30.56 14.21 53 123641 117816 110347789
Acute pulmonary oedema 30.31 14.21 62 123632 16934 110448671
Jaw operation 30.23 14.21 16 123678 828 110464777
Leukonychia 30.09 14.21 9 123685 97 110465508
Pneumonia aspiration 29.92 14.21 28 123666 81205 110384400
Basal cell carcinoma 29.79 14.21 7 123687 45263 110420342
Corneal disorder 29.59 14.21 24 123670 2573 110463032
Distichiasis 29.55 14.21 7 123687 27 110465578
Influenza 29.45 14.21 94 123600 169007 110296598
Catheter site bruise 29.40 14.21 14 123680 577 110465028
Portal hypertension 29.39 14.21 42 123652 8595 110457010
Hand dermatitis 29.08 14.21 15 123679 736 110464869
Hyperchlorhydria 28.93 14.21 22 123672 2147 110463458
Glossopharyngeal nerve paralysis 28.76 14.21 8 123686 65 110465540
Performance status decreased 28.74 14.21 38 123656 7228 110458377
Myocardial infarction 28.64 14.21 114 123580 191969 110273636
Blood pressure fluctuation 28.50 14.21 25 123669 74799 110390806
Mean platelet volume decreased 28.45 14.21 26 123668 3274 110462331
Chronic kidney disease 28.45 14.21 26 123668 76265 110389340
Tachycardia 28.21 14.21 382 123312 226263 110239342
Vessel puncture site bruise 27.92 14.21 13 123681 509 110465096
Abnormal behaviour 27.84 14.21 5 123689 39034 110426571
Perforation 27.83 14.21 20 123674 1790 110463815
Spinal pain 27.81 14.21 63 123631 18452 110447153
Coeliac disease 27.79 14.21 7 123687 43180 110422425
Post-traumatic pain 27.71 14.21 13 123681 518 110465087
Fluid retention 27.70 14.21 39 123655 94268 110371337
Anaphylactoid reaction 27.47 14.21 36 123658 6790 110458815
Ejection fraction abnormal 27.40 14.21 26 123668 3434 110462171
Dizziness 27.39 14.21 584 123110 697609 109767996
Pneumonitis chemical 27.39 14.21 14 123680 674 110464931
Botryomycosis 27.37 14.21 8 123686 79 110465526
Vascular fragility 27.34 14.21 10 123684 209 110465396
Peripheral motor neuropathy 27.33 14.21 28 123666 4058 110461547
Excessive eye blinking 27.25 14.21 20 123674 1850 110463755
Breast cellulitis 27.17 14.21 12 123682 415 110465190
Troponin I increased 27.15 14.21 32 123662 5420 110460185
Metastases to heart 27.03 14.21 12 123682 420 110465185
Therapy interrupted 26.89 14.21 11 123683 49811 110415794
Respiratory arrest 26.74 14.21 16 123678 58283 110407322
Metabolic acidosis 26.64 14.21 44 123650 99700 110365905
Radiation pneumonitis 26.63 14.21 29 123665 4507 110461098
Nasal disorder 26.50 14.21 28 123666 4206 110461399
Blood glucose increased 26.48 14.21 69 123625 132427 110333178
Tremor 26.47 14.21 344 123350 201888 110263717
Disorientation 26.45 14.21 24 123670 70647 110394958
Limb injury 26.45 14.21 5 123689 37631 110427974
Granulomatous lymphadenitis 26.38 14.21 12 123682 445 110465160
Pruritus 26.27 14.21 475 123219 581085 109884520
Vulvovaginal inflammation 26.26 14.21 14 123680 735 110464870
Full blood count abnormal 26.25 14.21 15 123679 56037 110409568
Anastomotic complication 25.98 14.21 13 123681 598 110465007
Axillary vein thrombosis 25.97 14.21 14 123680 752 110464853
Brain cancer metastatic 25.96 14.21 11 123683 343 110465262
Amnesia 25.90 14.21 49 123645 105359 110360246
Therapy cessation 25.72 14.21 9 123685 44848 110420757
Rash pustular 25.53 14.21 49 123645 12780 110452825
Bronchitis 25.49 14.21 90 123604 156942 110308663
Asthenopia 25.48 14.21 24 123670 3140 110462465
Sopor 25.38 14.21 5 123689 36541 110429064
Metastases to adrenals 25.31 14.21 18 123676 1585 110464020
Subdural haematoma 25.29 14.21 5 123689 36449 110429156
Biliary sepsis 25.26 14.21 19 123675 1824 110463781
Breast inflammation 25.26 14.21 9 123685 174 110465431
Movement disorder 25.24 14.21 5 123689 36399 110429206
Blood lactate dehydrogenase abnormal 25.16 14.21 13 123681 640 110464965
Pulmonary toxicity 25.13 14.21 59 123635 17687 110447918
Urinary retention 24.53 14.21 25 123669 69658 110395947
Nail bed bleeding 24.51 14.21 14 123680 842 110464763
Tumour marker abnormal 24.25 14.21 10 123684 291 110465314
Neurological decompensation 24.20 14.21 34 123660 6849 110458756
Neuromuscular toxicity 24.13 14.21 11 123683 410 110465195
Varicose vein 23.99 14.21 34 123660 6906 110458699
Osteitis condensans 23.90 14.21 6 123688 31 110465574
Sinus congestion 23.78 14.21 3 123691 30456 110435149
Lupus-like syndrome 23.70 14.21 8 123686 40784 110424821
Tachypnoea 23.62 14.21 97 123597 39298 110426307
Dysuria 23.50 14.21 131 123563 60100 110405505
Hypervolaemia 23.50 14.21 13 123681 49447 110416158
Gamma-glutamyltransferase abnormal 23.48 14.21 14 123680 913 110464692
No adverse event 23.33 14.21 152 123542 73687 110391918
Palmar erythema 23.31 14.21 20 123674 2318 110463287
Nephrolithiasis 23.03 14.21 24 123670 66188 110399417
Joint injury 22.97 14.21 8 123686 39986 110425619
Dysaesthesia 22.86 14.21 33 123661 6814 110458791
Metastases to the mediastinum 22.79 14.21 13 123681 780 110464825
Insomnia 22.69 14.21 276 123418 360314 110105291
Muscular weakness 22.48 14.21 174 123520 248294 110217311
Unwanted pregnancy 22.48 14.21 6 123688 41 110465564
Psychological trauma 22.39 14.21 17 123677 1656 110463949
Ear malformation 22.33 14.21 5 123689 14 110465591
Metastases to bone marrow 22.32 14.21 14 123680 1000 110464605
Angioedema 22.31 14.21 48 123646 98452 110367153
Calcium ionised increased 22.21 14.21 10 123684 362 110465243
Intracranial pressure increased 21.91 14.21 41 123653 10494 110455111
Respiratory tract congestion 21.90 14.21 4 123690 30853 110434752
Lipidosis 21.76 14.21 6 123688 47 110465558
Conjunctivitis 21.69 14.21 85 123609 33707 110431898
Lipoprotein increased 21.60 14.21 5 123689 17 110465588
SARS-CoV-2 test positive 21.52 14.21 54 123640 16881 110448724
Capillary leak syndrome 21.50 14.21 27 123667 4881 110460724
Upper respiratory tract infection 21.50 14.21 75 123619 131253 110334352
Herpangina 21.44 14.21 6 123688 50 110465555
Multicentric reticulohistiocytosis 21.37 14.21 5 123689 18 110465587
Lower limb fracture 21.30 14.21 32 123662 75316 110390289
Disability 21.27 14.21 4 123690 30219 110435386
Pulmonary hypoplasia 21.23 14.21 6 123688 52 110465553
Lymphangitis 21.09 14.21 16 123678 1556 110464049
Peripheral sensorimotor neuropathy 21.07 14.21 24 123670 3919 110461686
Vulvovaginal candidiasis 21.05 14.21 22 123672 3263 110462342
Entropion 20.99 14.21 7 123687 110 110465495
Seroma 20.96 14.21 22 123672 3279 110462326
Oedema 20.95 14.21 143 123551 209833 110255772
Anastomotic leak 20.93 14.21 15 123679 1337 110464268
Barotrauma 20.92 14.21 8 123686 190 110465415
Cerebrovascular accident 20.91 14.21 118 123576 181166 110284439
Hormone receptor positive breast cancer 20.84 14.21 11 123683 566 110465039
Ascites 20.75 14.21 176 123518 92632 110372973
Dysentery 20.74 14.21 15 123679 1356 110464249
Oxygen saturation decreased 20.53 14.21 267 123427 156715 110308890
Blood creatine increased 20.51 14.21 42 123652 11479 110454126
Osteolysis 20.50 14.21 28 123666 5495 110460110
Breast sarcoma 20.42 14.21 4 123690 4 110465601
Hepatopulmonary syndrome 20.39 14.21 8 123686 204 110465401
Folate deficiency 20.38 14.21 25 123669 4413 110461192
Noninfective conjunctivitis 20.28 14.21 6 123688 62 110465543
Poisoning 20.17 14.21 4 123690 29101 110436504
Alopecia totalis 20.12 14.21 10 123684 453 110465152
Cardiac failure acute 20.10 14.21 66 123628 24012 110441593
Liver ablation 20.05 14.21 5 123689 25 110465580
Infusion related reaction 19.96 14.21 563 123131 380599 110085006
Gastroenteritis radiation 19.94 14.21 12 123682 796 110464809
Inflammatory carcinoma of the breast 19.89 14.21 5 123689 26 110465579
Gout 19.85 14.21 8 123686 36558 110429047
Muscle spasms 19.82 14.21 207 123487 277950 110187655
Coagulation factor decreased 19.78 14.21 9 123685 334 110465271
Gastritis 19.77 14.21 115 123579 53584 110412021
Neck pain 19.70 14.21 71 123623 123059 110342546
Encephalopathy 19.63 14.21 38 123656 81017 110384588
Mucosal dryness 19.56 14.21 24 123670 4239 110461366
Dry mouth 19.53 14.21 137 123557 199811 110265794
Nasopharyngitis 19.43 14.21 317 123377 394044 110071561
Orthopnoea 19.41 14.21 40 123654 10981 110454624
Haemorrhoids 19.19 14.21 85 123609 35587 110430018
Brain natriuretic peptide decreased 19.18 14.21 6 123688 76 110465529
Adenocarcinoma gastric 19.15 14.21 17 123677 2062 110463543
Soft tissue infection 19.12 14.21 26 123668 5081 110460524
Transaminases 19.03 14.21 6 123688 78 110465527
Ulcerative keratitis 18.97 14.21 25 123669 4741 110460864
Multiple sclerosis 18.97 14.21 3 123691 25695 110439910
Skin mass 18.93 14.21 37 123657 9779 110455826
Nail bed tenderness 18.81 14.21 9 123685 375 110465230
Viral infection 18.77 14.21 19 123675 53120 110412485
Malignant pleural effusion 18.71 14.21 23 123671 4070 110461535
Blood magnesium decreased 18.70 14.21 57 123637 19939 110445666
Meibomianitis 18.69 14.21 6 123688 83 110465522
Toxic neuropathy 18.64 14.21 13 123681 1110 110464495
Vaginal prolapse 18.59 14.21 9 123685 385 110465220
Protein total decreased 18.57 14.21 39 123655 10851 110454754
Hypoxia 18.52 14.21 224 123470 129291 110336314
Polyneuropathy chronic 18.50 14.21 5 123689 36 110465569
Tidal volume decreased 18.50 14.21 6 123688 86 110465519
Gastrointestinal stenosis 18.38 14.21 9 123685 395 110465210
Mouth swelling 18.36 14.21 31 123663 7323 110458282
Chronic sinusitis 18.35 14.21 3 123691 25081 110440524
Pain in extremity 18.34 14.21 410 123284 486708 109978897
Eye swelling 18.32 14.21 7 123687 33041 110432564
Haematochezia 18.23 14.21 67 123627 115457 110350148
Osteochondrosis 18.19 14.21 18 123676 2503 110463102
Xerophthalmia 18.14 14.21 12 123682 939 110464666
Obstructive airways disorder 18.09 14.21 15 123679 46134 110419471
Gait apraxia 18.04 14.21 5 123689 40 110465565
Flatulence 18.02 14.21 19 123675 52130 110413475
Tumour invasion 17.99 14.21 10 123684 571 110465034
Hepatic cirrhosis 17.91 14.21 30 123664 67596 110398009
Cardiac murmur 17.90 14.21 3 123691 24625 110440980
Hepatic mass 17.84 14.21 19 123675 2879 110462726
Pulmonary embolism 17.82 14.21 338 123356 214136 110251469
Aphasia 17.72 14.21 24 123670 58973 110406632
Laboratory test abnormal 17.68 14.21 14 123680 44065 110421540
Brain neoplasm 17.56 14.21 28 123666 6309 110459296
Plantar erythema 17.46 14.21 8 123686 302 110465303
Intentional product use issue 17.45 14.21 185 123509 247721 110217884
Brain oedema 17.42 14.21 75 123619 31023 110434582
Metastases to the respiratory system 17.39 14.21 3 123691 0 110465605
Simple mastectomy 17.39 14.21 3 123691 0 110465605
Globulinuria 17.39 14.21 3 123691 0 110465605
Respiratory depression 17.37 14.21 7 123687 31994 110433611
Pituitary tumour 17.36 14.21 13 123681 1240 110464365
Immunodeficiency 17.34 14.21 11 123683 38827 110426778
Transient ischaemic attack 17.30 14.21 28 123666 63954 110401651
Vocal cord paralysis 17.27 14.21 19 123675 2987 110462618
Hyperproteinaemia 17.21 14.21 8 123686 312 110465293
Blood triglycerides increased 17.20 14.21 3 123691 23923 110441682
Arteriospasm coronary 17.19 14.21 34 123660 9066 110456539
Hepatitis 17.16 14.21 48 123646 90006 110375599
Tumour haemorrhage 17.11 14.21 25 123669 5220 110460385
Eye irritation 17.08 14.21 8 123686 33444 110432161
Emotional distress 17.06 14.21 15 123679 44832 110420773
Cytokine release syndrome 16.99 14.21 33 123661 70273 110395332
Subarachnoid haemorrhage 16.96 14.21 6 123688 29696 110435909
Dandy-Walker syndrome 16.88 14.21 5 123689 52 110465553
Hepatic cancer recurrent 16.86 14.21 8 123686 327 110465278
Gastric perforation 16.82 14.21 24 123670 4905 110460700
Bone disorder 16.72 14.21 57 123637 21135 110444470
Nasal discomfort 16.70 14.21 27 123667 6154 110459451
Injection site rash 16.70 14.21 3 123691 23416 110442189
Naevus haemorrhage 16.70 14.21 6 123688 119 110465486
Stress 16.68 14.21 61 123633 105287 110360318
Abdominal distension 16.61 14.21 121 123573 174982 110290623
Palpitations 16.51 14.21 260 123434 158952 110306653
Overflow diarrhoea 16.47 14.21 7 123687 220 110465385
Merycism 16.42 14.21 8 123686 347 110465258
Taste disorder 16.41 14.21 30 123664 65357 110400248
Nail disorder 16.36 14.21 116 123578 57819 110407786
Clostridial infection 16.31 14.21 27 123667 6275 110459330
Hypophosphatasia 16.29 14.21 6 123688 128 110465477
Paralysis recurrent laryngeal nerve 16.27 14.21 7 123687 227 110465378
Gingival bleeding 16.22 14.21 54 123640 19785 110445820
Hypertensive crisis 16.21 14.21 62 123632 24310 110441295
Blood phosphorus decreased 16.15 14.21 30 123664 7635 110457970
Pseudomonal sepsis 16.13 14.21 33 123661 9013 110456592
Lymph node fibrosis 16.04 14.21 4 123690 20 110465585
Ischaemia 16.04 14.21 33 123661 9050 110456555
Leukaemia cutis 15.96 14.21 7 123687 238 110465367
Urogenital prolapse 15.88 14.21 4 123690 21 110465584
Device occlusion 15.83 14.21 45 123649 15140 110450465
Retinal detachment 15.82 14.21 37 123657 11063 110454542
Apical granuloma 15.72 14.21 5 123689 67 110465538
Hyperaesthesia 15.71 14.21 44 123650 14683 110450922
Carbohydrate antigen 19-9 increased 15.67 14.21 9 123685 547 110465058
Head injury 15.64 14.21 15 123679 43002 110422603
Oropharyngeal candidiasis 15.62 14.21 15 123679 2011 110463594
Ovarian failure 15.50 14.21 11 123683 965 110464640
Blood creatine phosphokinase increased 15.42 14.21 37 123657 73040 110392565
Bronchiectasis 15.40 14.21 11 123683 36482 110429123
Diabetes mellitus inadequate control 15.39 14.21 7 123687 29768 110435837
Accidental exposure to product 15.37 14.21 20 123674 49988 110415617
Hallucination, visual 15.36 14.21 13 123681 39592 110426013
Human epidermal growth factor receptor increased 15.32 14.21 3 123691 3 110465602
Catheter site inflammation 15.28 14.21 12 123682 1228 110464377
Pleural neoplasm 15.26 14.21 8 123686 406 110465199
Adverse reaction 15.23 14.21 7 123687 29587 110436018
Spider naevus 15.18 14.21 6 123688 156 110465449
Renal failure 15.18 14.21 171 123523 226403 110239202
Hypotension 15.18 14.21 458 123236 523391 109942214
Sinus bradycardia 15.13 14.21 7 123687 29476 110436129
Dental fistula 15.12 14.21 9 123685 585 110465020
Device issue 15.12 14.21 10 123684 34525 110431080
Secondary cerebellar degeneration 15.08 14.21 5 123689 77 110465528
Neutropenic colitis 15.07 14.21 30 123664 8035 110457570
Appendiceal abscess 15.06 14.21 8 123686 417 110465188
Cardiac arrest 15.02 14.21 144 123550 196609 110268996
Delusion 15.00 14.21 4 123690 23751 110441854
Sinus disorder 14.98 14.21 9 123685 32719 110432886
Nephropathy toxic 14.94 14.21 6 123688 27472 110438133
Aspergillus infection 14.93 14.21 5 123689 25611 110439994
Pustule 14.91 14.21 19 123675 3485 110462120
Ovarian vein thrombosis 14.91 14.21 5 123689 80 110465525
Lip swelling 14.83 14.21 21 123673 50646 110414959
Tumour lysis syndrome 14.80 14.21 71 123623 30730 110434875
Skin infection 14.76 14.21 57 123637 22452 110443153
Haemorrhage intracranial 14.68 14.21 7 123687 28962 110436643
Arachnoid cyst 14.63 14.21 8 123686 442 110465163
Hepatic cyst 14.61 14.21 29 123665 7754 110457851
Metastases to pituitary gland 14.55 14.21 4 123690 31 110465574
Tongue coated 14.54 14.21 14 123680 1882 110463723
Amenorrhoea 14.53 14.21 32 123662 9199 110456406
Gastrooesophageal reflux disease 14.48 14.21 130 123564 179846 110285759
Dysarthria 14.48 14.21 47 123647 84074 110381531
Breast operation 14.47 14.21 8 123686 452 110465153
Fear 14.47 14.21 4 123690 23189 110442416
Corneal bleeding 14.44 14.21 4 123690 32 110465573
Bone marrow infiltration 14.29 14.21 10 123684 858 110464747
Seizure 14.29 14.21 336 123358 220849 110244756
Electric shock sensation 14.25 14.21 14 123680 1930 110463675
Joint stiffness 14.22 14.21 34 123660 67209 110398396
Tumour ulceration 14.21 14.21 7 123687 311 110465294

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FD01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
ATC L01FY01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
Combinations of monoclonal antibodies and antibody drug conjugates
FDA MoA N0000020008 HER2/Neu/cerbB2 Antagonists
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175661 HER2/neu Receptor Antagonist
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

L01FD HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors 5 drugs
margetuximabpertuzumabtrastuzumab deruxtecantrastuzumab emtansinezanidatamab-hrii
L01FY Combinations of monoclonal antibodies and antibody drug conjugates 3 drugs
nivolumabpertuzumabrelatlimab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secondary malignant neoplasm of female breast indication 94297009
Secondary malignant neoplasm of stomach indication 94606003
Human epidermal growth factor 2 positive gastric cancer indication 102453009
HER2-positive salivary gland tumors indication 255072001
HER2-positive rectal cancer indication 363351006 DOID:1993
HER2-positive colon cancer indication 363406005 DOID:219
HER2-positive carcinoma of breast indication 427685000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Receptor tyrosine-protein kinase erbB-2 Kinase ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
P188ANX8CK UNII
D03257 KEGG_DRUG
4021140 VUID
N0000148593 NUI
4021140 VANDF
4038908 VANDF
C0728747 UMLSCUI
CHEBI:231601 CHEBI
CHEMBL1201585 ChEMBL_ID
DB00072 DRUGBANK_ID
D000068878 MESH_DESCRIPTOR_UI
7637 INN_ID
5082 IUPHAR_LIGAND_ID
C000630669 MESH_SUPPLEMENTAL_RECORD_UI
101306 RXNORM
11893 MMSL
266775 MMSL
33398 MMSL
7554 MMSL
d04357 MMSL
007663 NDDF
017423 NDDF
327397006 SNOMEDCT_US
387003001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Trazimera HUMAN PRESCRIPTION DRUG LABEL 1 0069-0308 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 30 sections
Herceptin Hylecta HUMAN PRESCRIPTION DRUG LABEL 2 50242-077 INJECTION, SOLUTION 600 mg SUBCUTANEOUS BLA 30 sections
Herceptin HUMAN PRESCRIPTION DRUG LABEL 1 50242-132 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 30 sections
Phesgo HUMAN PRESCRIPTION DRUG LABEL 3 50242-245 INJECTION, SOLUTION 600 mg SUBCUTANEOUS BLA 30 sections
Phesgo HUMAN PRESCRIPTION DRUG LABEL 3 50242-260 INJECTION, SOLUTION 600 mg SUBCUTANEOUS BLA 30 sections
Kanjinti HUMAN PRESCRIPTION DRUG LABEL 1 55513-132 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 420 mg INTRAVENOUS BLA 30 sections
Kanjinti HUMAN PRESCRIPTION DRUG LABEL 1 55513-141 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 30 sections
HERZUMA HUMAN PRESCRIPTION DRUG LABEL 1 63459-303 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 27 sections
OGIVRI HUMAN PRESCRIPTION DRUG LABEL 1 67457-991 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 29 sections
HERCESSI HUMAN PRESCRIPTION DRUG LABEL 1 69448-015 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 24 sections
HERCESSI HUMAN PRESCRIPTION DRUG LABEL 1 69448-016 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 420 mg INTRAVENOUS BLA 24 sections
Ontruzant HUMAN PRESCRIPTION DRUG LABEL 1 78206-147 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 31 sections
OGIVRI HUMAN PRESCRIPTION DRUG LABEL 1 83257-001 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg INTRAVENOUS BLA 28 sections
OGIVRI HUMAN PRESCRIPTION DRUG LABEL 1 83257-003 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 420 mg INTRAVENOUS BLA 28 sections