denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
human origin 4965 615258-40-7

Description:

MoleculeDescription

Synonyms:

  • denosumab
  • prolia
  • AMG 162
  • AMG162
A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.33 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 1, 2010 FDA AMGEN
May 26, 2010 EMA Amgen Europe B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 38447.08 10.40 28108 224860 1074144 89301335
Osteonecrosis of jaw 13777.45 10.40 4869 248099 34234 90341245
Death 6806.44 10.40 7310 245658 449241 89926238
Spinal fracture 3326.01 10.40 1490 251478 20526 90354953
Hypocalcaemia 2501.52 10.40 1527 251441 40841 90334638
Bone pain 2431.18 10.40 1730 251238 60253 90315226
Tooth disorder 2155.17 10.40 1243 251725 29847 90345632
Atypical femur fracture 1906.38 10.40 706 252262 5715 90369764
Pain in jaw 1705.21 10.40 1262 251706 46723 90328756
Tooth extraction 1589.20 10.40 732 252236 10781 90364698
Back pain 1494.45 10.40 2950 250018 314225 90061254
Myalgia 1209.24 10.40 1927 251041 173198 90202281
Drug ineffective 1188.70 10.40 1275 251693 1383023 88992456
Metastases to bone 1052.92 10.40 735 252233 24770 90350709
Pain in extremity 1041.61 10.40 3187 249781 447342 89928137
Fracture 1031.99 10.40 687 252281 21389 90354090
Thoracic vertebral fracture 1027.33 10.40 432 252536 5042 90370437
Occupational exposure to product 1003.80 10.40 345 252623 2186 90373293
Bone density abnormal 959.16 10.40 380 252588 3760 90371719
Bone density decreased 901.80 10.40 577 252391 16768 90358711
Accidental exposure to product 894.90 10.40 824 252144 41542 90333937
Tooth fracture 884.12 10.40 508 252460 12092 90363387
Pemphigus 850.00 10.40 12 252956 326852 90048627
Maternal exposure during pregnancy 834.71 10.40 41 252927 360022 90015457
Femur fracture 800.84 10.40 805 252163 45277 90330202
Lumbar vertebral fracture 800.42 10.40 399 252569 7059 90368420
Spinal compression fracture 786.81 10.40 504 252464 14674 90360805
Infusion related reaction 763.88 10.40 124 252844 416656 89958823
Synovitis 744.16 10.40 44 252924 329708 90045771
Toothache 738.95 10.40 562 252406 21668 90353811
Pathological fracture 724.98 10.40 407 252561 9253 90366226
Systemic lupus erythematosus 723.94 10.40 82 252886 361814 90013665
Product storage error 697.80 10.40 523 252445 19718 90355761
Hip fracture 693.99 10.40 641 252327 32436 90343043
Blood parathyroid hormone increased 677.75 10.40 281 252687 3156 90372323
Arthralgia 651.55 10.40 4050 248918 774472 89601007
Glossodynia 645.82 10.40 72 252896 321707 90053772
Anti-cyclic citrullinated peptide antibody positive 641.62 10.40 3 252965 236430 90139049
Contraindicated product administered 619.44 10.40 81 252887 320058 90055421
Exposure during pregnancy 618.59 10.40 9 252959 238401 90137078
Drug intolerance 613.78 10.40 241 252727 447350 89928129
Hand deformity 610.97 10.40 60 252908 296302 90079177
Exposed bone in jaw 606.78 10.40 248 252720 2678 90372801
Rebound effect 601.98 10.40 357 252611 9027 90366452
Intercepted product administration error 600.46 10.40 182 252786 716 90374763
Pericarditis 591.78 10.40 42 252926 270109 90105370
Helicobacter infection 582.49 10.40 10 252958 226840 90148639
Duodenal ulcer perforation 571.35 10.40 9 252959 221279 90154200
Treatment failure 568.94 10.40 85 252883 303843 90071636
Tooth loss 563.43 10.40 317 252651 7237 90368242
Jaw disorder 560.17 10.40 285 252683 5274 90370205
Breast cancer metastatic 559.83 10.40 408 252560 14724 90360755
Dental care 559.55 10.40 188 252780 1100 90374379
Metastases to liver 550.26 10.40 530 252438 28277 90347202
Dental implantation 546.90 10.40 169 252799 720 90374759
Hepatic enzyme increased 544.88 10.40 165 252803 360571 90014908
Wound 524.83 10.40 104 252864 302876 90072603
Groin pain 520.50 10.40 359 252609 11854 90363625
Condition aggravated 517.65 10.40 540 252428 595005 89780474
Folliculitis 508.86 10.40 13 252955 204340 90171139
Product use issue 483.77 10.40 159 252809 329760 90045719
Toxicity to various agents 461.96 10.40 117 252851 287729 90087750
Bone loss 453.79 10.40 213 252755 3279 90372200
Rheumatoid factor positive 451.75 10.40 5 252963 171645 90203834
Osteomyelitis 444.84 10.40 465 252503 27381 90348098
Psoriatic arthropathy 440.99 10.40 58 252910 228277 90147202
Joint swelling 438.68 10.40 455 252513 502845 89872634
Malignant neoplasm progression 438.02 10.40 940 252028 105930 90269549
Therapeutic product effect decreased 437.46 10.40 117 252851 277454 90098025
Muscle injury 436.96 10.40 12 252956 176642 90198837
Drug hypersensitivity 435.52 10.40 392 252576 463217 89912262
Exostosis of jaw 434.53 10.40 155 252813 1112 90374367
Type 2 diabetes mellitus 416.52 10.40 42 252926 203202 90172277
Neoplasm progression 415.62 10.40 565 252403 43921 90331558
Product use in unapproved indication 404.78 10.40 217 252751 336019 90039460
Loose tooth 397.96 10.40 199 252769 3544 90371935
Abdominal discomfort 388.95 10.40 456 252512 476872 89898607
Atypical fracture 385.18 10.40 131 252837 800 90374679
Blood calcium decreased 385.14 10.40 448 252520 29734 90345745
Swelling 382.07 10.40 364 252604 418694 89956785
Irritable bowel syndrome 379.05 10.40 62 252906 207386 90168093
Liver injury 374.90 10.40 26 252942 170541 90204938
Completed suicide 373.94 10.40 6 252962 145052 90230427
Confusional state 364.44 10.40 325 252643 385880 89989599
Terminal state 363.45 10.40 171 252797 2647 90372832
Compression fracture 361.98 10.40 253 252715 8536 90366943
Wheezing 344.92 10.40 117 252851 237963 90137516
Dental caries 339.34 10.40 270 252698 11127 90364352
Foot fracture 329.62 10.40 389 252579 26217 90349262
Fall 327.25 10.40 2383 250585 479427 89896052
Osteonecrosis 314.12 10.40 377 252591 25864 90349615
C-reactive protein abnormal 313.83 10.40 9 252959 127420 90248059
Bone disorder 311.54 10.40 353 252615 22767 90352712
Injury 296.42 10.40 91 252877 197258 90178221
Lower respiratory tract infection 295.41 10.40 166 252802 250493 90124986
Hypersensitivity 289.86 10.40 516 252452 454161 89921318
Swollen joint count increased 280.91 10.40 6 252962 111200 90264279
Weight increased 278.54 10.40 461 252507 417466 89958013
Intentional product use issue 265.27 10.40 137 252831 216755 90158724
Multiple fractures 264.51 10.40 217 252751 9345 90366134
Metastases to lung 257.12 10.40 268 252700 15723 90359756
Osteonecrosis of external auditory canal 255.02 10.40 66 252902 118 90375361
Pelvic fracture 253.60 10.40 260 252708 14959 90360520
Facet joint syndrome 249.74 10.40 5 252963 98384 90277095
Breast cancer 249.68 10.40 498 252470 53263 90322216
Blister 249.62 10.40 207 252761 254791 90120688
Discomfort 247.84 10.40 240 252728 274095 90101384
Arthropathy 247.72 10.40 400 252568 365842 90009637
Intentional overdose 245.64 10.40 3 252965 93831 90281648
Wrist fracture 239.02 10.40 255 252713 15369 90360110
Investigation 237.55 10.40 107 252861 1490 90373989
Blood calcium increased 236.20 10.40 225 252743 11833 90363646
Endodontic procedure 235.49 10.40 137 252831 3338 90372141
Overdose 234.52 10.40 74 252894 157635 90217844
Fibromyalgia 229.80 10.40 146 252822 206123 90169356
Neutropenia 225.79 10.40 1230 251738 223674 90151805
Rheumatoid arthritis 223.42 10.40 420 252548 362194 90013285
Hospitalisation 222.76 10.40 825 252143 127275 90248204
Drug interaction 217.57 10.40 271 252697 276182 90099297
Prescribed overdose 217.07 10.40 14 252954 97611 90277868
Tooth abscess 216.73 10.40 248 252720 16165 90359314
Vomiting 215.72 10.40 1304 251664 786989 89588490
Breast cancer stage III 215.52 10.40 4 252964 84443 90291036
Sinusitis 215.25 10.40 393 252575 342695 90032784
Lip dry 214.42 10.40 18 252950 100937 90274542
Metastases to lymph nodes 213.70 10.40 210 252758 11479 90364000
Drug abuse 205.81 10.40 5 252963 82342 90293137
Jaw operation 201.94 10.40 80 252888 791 90374688
Rib fracture 201.73 10.40 305 252663 26130 90349349
Stress fracture 200.48 10.40 177 252791 8434 90367045
Temporomandibular joint syndrome 199.81 10.40 130 252838 3887 90371592
Gingival disorder 198.12 10.40 129 252839 3862 90371617
Periodontitis 197.32 10.40 127 252841 3726 90371753
Tooth infection 197.25 10.40 262 252706 19908 90355571
Carbohydrate antigen 15-3 increased 193.82 10.40 100 252868 1907 90373572
Sleep disorder due to general medical condition, insomnia type 192.02 10.40 60 252908 128634 90246845
Osteoporotic fracture 191.93 10.40 135 252833 4601 90370878
Dental operation 191.87 10.40 93 252875 1543 90373936
Obesity 191.61 10.40 32 252936 105475 90270004
Spinal pain 191.12 10.40 228 252740 15539 90359940
Hypercalcaemia 184.64 10.40 338 252630 33902 90341577
Gingival pain 183.19 10.40 177 252791 9475 90366004
Oedema 182.27 10.40 174 252794 200121 90175358
Deep vein thrombosis postoperative 182.16 10.40 3 252965 70806 90304673
Tumour marker increased 178.09 10.40 140 252828 5667 90369812
Acute kidney injury 177.83 10.40 394 252574 319993 90055486
Infection 173.85 10.40 480 252488 361614 90013865
Incorrect route of product administration 171.39 10.40 413 252555 50213 90325266
Gingivitis 170.68 10.40 168 252800 9201 90366278
Abscess jaw 170.12 10.40 83 252885 1398 90374081
Hypotension 169.48 10.40 414 252554 324983 90050496
Cystitis 168.52 10.40 488 252480 66230 90309249
Musculoskeletal stiffness 164.28 10.40 365 252603 296167 90079312
Asthma 163.13 10.40 265 252703 241895 90133584
Blood calcium abnormal 161.23 10.40 88 252880 1889 90373590
Metastases to central nervous system 161.09 10.40 221 252747 17321 90358158
Eczema 159.74 10.40 413 252555 52457 90323022
Bedridden 157.78 10.40 182 252786 11966 90363513
Metastases to spine 157.07 10.40 109 252859 3634 90371845
Migraine 155.73 10.40 181 252787 190211 90185268
Grip strength decreased 155.55 10.40 34 252934 92542 90282937
Wound infection 154.51 10.40 52 252916 106350 90269129
Gingival swelling 151.89 10.40 120 252848 4893 90370586
Artificial crown procedure 151.05 10.40 53 252915 360 90375119
Suicide attempt 150.76 10.40 17 252951 75382 90300097
Pulmonary fibrosis 150.18 10.40 56 252912 107447 90268032
Prescribed underdose 149.78 10.40 17 252951 75002 90300477
Nasopharyngitis 148.65 10.40 608 252360 406496 89968983
Pyrexia 148.50 10.40 1157 251811 659328 89716151
Hypophosphataemia 146.87 10.40 194 252774 14660 90360819
Musculoskeletal pain 146.59 10.40 898 252070 170353 90205126
Gingival recession 146.08 10.40 79 252889 1664 90373815
Osteitis 144.71 10.40 104 252864 3669 90371810
Somnolence 142.51 10.40 227 252741 208857 90166622
Tetany 141.87 10.40 89 252879 2495 90372984
Hyperaesthesia teeth 141.80 10.40 85 252883 2192 90373287
Dislocation of vertebra 141.41 10.40 3 252965 55965 90319514
Hypercholesterolaemia 140.20 10.40 53 252915 100839 90274640
Delirium 136.60 10.40 60 252908 104299 90271180
Dyspnoea 135.62 10.40 1692 251276 879263 89496216
Headache 135.08 10.40 1651 251317 861095 89514384
Upper limb fracture 134.46 10.40 227 252741 21351 90354128
Inflammation 134.33 10.40 181 252787 178411 90197068
Joint range of motion decreased 132.79 10.40 110 252858 135533 90239946
Peripheral venous disease 132.79 10.40 35 252933 83886 90291593
Musculoskeletal discomfort 132.37 10.40 222 252746 20769 90354710
Body height decreased 130.59 10.40 164 252804 11785 90363694
Ill-defined disorder 127.64 10.40 199 252769 184692 90190787
Product quality issue 127.59 10.40 32 252936 79293 90296186
Hyperparathyroidism 125.74 10.40 91 252877 3246 90372233
Peripheral swelling 123.65 10.40 663 252305 412443 89963036
Adjustment disorder with depressed mood 123.65 10.40 9 252959 56744 90318735
Influenza like illness 123.60 10.40 499 252469 80112 90295367
C-telopeptide increased 121.14 10.40 28 252940 21 90375458
Dental restoration failure 121.14 10.40 61 252907 1103 90374376
Blepharospasm 120.20 10.40 9 252959 55436 90320043
Vitamin D decreased 119.28 10.40 157 252811 11822 90363657
Femoral neck fracture 119.16 10.40 145 252823 10088 90365391
Abortion spontaneous 116.55 10.40 9 252959 54047 90321432
Neoplasm malignant 116.40 10.40 278 252690 33602 90341877
Pneumonia 116.37 10.40 1179 251789 636880 89738599
PIK3CA-activated mutation 116.30 10.40 60 252908 1144 90374335
Psoriasis 115.99 10.40 145 252823 147609 90227870
White blood cell count decreased 115.60 10.40 831 252137 166278 90209201
Dermatitis 115.59 10.40 216 252752 22004 90353475
Gastrointestinal disorder 115.28 10.40 351 252617 256336 90119143
Bradycardia 114.91 10.40 45 252923 83802 90291677
Tachycardia 114.37 10.40 164 252804 157509 90217970
Bursitis 113.30 10.40 120 252848 131534 90243945
X-ray abnormal 112.59 10.40 3 252965 45421 90330058
Autoimmune disorder 112.30 10.40 37 252931 76707 90298772
Red blood cell sedimentation rate increased 112.09 10.40 45 252923 82550 90292929
Depressed level of consciousness 112.07 10.40 32 252936 72752 90302727
Abdominal pain 111.92 10.40 647 252321 395074 89980405
Mastication disorder 111.30 10.40 75 252893 2381 90373098
Circumstance or information capable of leading to medication error 109.49 10.40 99 252869 4868 90370611
Suicidal ideation 105.65 10.40 37 252931 73818 90301661
Sequestrectomy 105.22 10.40 49 252919 740 90374739
Coma 102.85 10.40 37 252931 72595 90302884
Inappropriate schedule of product administration 102.78 10.40 744 252224 149189 90226290
Fractured sacrum 102.60 10.40 71 252897 2356 90373123
Cardiac arrest 100.37 10.40 87 252881 104848 90270631
Dental cleaning 99.24 10.40 22 252946 10 90375469
Oral pain 98.40 10.40 255 252713 32428 90343051
Lung disorder 98.12 10.40 167 252801 149716 90225763
C-reactive protein increased 97.36 10.40 227 252741 181162 90194317
Night sweats 97.32 10.40 130 252838 128636 90246843
Lactic acidosis 96.91 10.40 13 252955 50450 90325029
Radius fracture 95.89 10.40 84 252884 3960 90371519
Muscle spasms 95.75 10.40 1100 251868 250783 90124696
Wrong technique in product usage process 94.95 10.40 424 252544 71147 90304332
Blood phosphorus decreased 94.94 10.40 92 252876 4942 90370537
Serotonin syndrome 92.09 10.40 3 252965 37884 90337595
Drug-induced liver injury 91.20 10.40 71 252897 90247 90285232
No adverse event 90.69 10.40 38 252930 67944 90307535
Humerus fracture 89.43 10.40 123 252845 9662 90365817
Sleep disorder 88.74 10.40 271 252697 197759 90177720
Anxiety 88.34 10.40 505 252463 309267 90066212
Lupus-like syndrome 88.26 10.40 15 252953 48831 90326648
Rash pruritic 88.09 10.40 458 252510 81756 90293723
Hypertension 87.68 10.40 835 252133 456697 89918782
Seizure 86.83 10.40 185 252783 152444 90223035
Bone erosion 86.02 10.40 21 252947 53000 90322479
Chest pain 85.91 10.40 531 252437 319114 90056365
Road traffic accident 85.11 10.40 105 252863 107521 90267958
Jaw fistula 84.99 10.40 23 252945 53 90375426
Tibia fracture 83.80 10.40 94 252874 5993 90369486
Drug dose omission by device 83.73 10.40 122 252846 10109 90365370
Abdominal pain upper 83.63 10.40 564 252404 332110 90043369
Immobile 83.33 10.40 96 252872 6302 90369177
Febrile neutropenia 82.72 10.40 201 252767 158148 90217331
Tooth erosion 81.92 10.40 36 252932 471 90375008
Musculoskeletal chest pain 81.72 10.40 195 252773 23555 90351924
Multiple sclerosis relapse 80.52 10.40 23 252945 52282 90323197
Joint noise 80.31 10.40 86 252882 5204 90370275
Product dose omission issue 79.95 10.40 1200 251768 290487 90084992
Hypophosphatasia 79.76 10.40 22 252946 56 90375423
Depression 79.42 10.40 502 252466 300099 90075380
Blood parathyroid hormone abnormal 79.34 10.40 29 252939 225 90375254
Injection site reaction 79.14 10.40 84 252884 91996 90283483
Dental necrosis 78.83 10.40 25 252943 118 90375361
Muscle spasticity 78.70 10.40 5 252963 35317 90340162
Drug ineffective for unapproved indication 77.20 10.40 45 252923 66599 90308880
Contusion 76.85 10.40 400 252568 250816 90124663
Liver disorder 76.75 10.40 138 252830 121131 90254348
Dry skin 76.04 10.40 463 252505 87610 90287869
General physical health deterioration 74.15 10.40 634 252334 354481 90020998
Cardio-respiratory arrest 74.04 10.40 42 252926 63098 90312381
Anaphylactic reaction 73.94 10.40 81 252887 87443 90288036
Metabolic acidosis 72.87 10.40 32 252936 55644 90319835
Carcinoembryonic antigen increased 72.81 10.40 57 252911 2293 90373186
Gingival abscess 72.64 10.40 42 252926 1011 90374468
Jaw fracture 72.45 10.40 60 252908 2618 90372861
Metastases to pleura 70.84 10.40 53 252915 1991 90373488
Pulpitis dental 70.62 10.40 41 252927 995 90374484
Unresponsive to stimuli 70.46 10.40 11 252957 38110 90337369
Drug tolerance decreased 70.26 10.40 5 252963 32125 90343354
Feeling abnormal 70.23 10.40 745 252223 166490 90208989
Amnesia 70 10.40 122 252846 108383 90267096
Parathyroid tumour malignant 69.85 10.40 19 252949 45 90375434
Premature delivery 69.83 10.40 12 252956 38750 90336729
Foetal exposure during pregnancy 69.76 10.40 17 252951 42958 90332521
Onychomadesis 69.39 10.40 21 252947 45977 90329502
Intentional self-injury 68.97 10.40 3 252965 29331 90346148
Agitation 68.69 10.40 52 252916 67046 90308433
Metastases to skin 68.68 10.40 53 252915 2087 90373392
Hand fracture 68.39 10.40 90 252878 6775 90368704
Scoliosis 66.86 10.40 102 252866 8805 90366674
Bone lesion 66.63 10.40 86 252882 6351 90369128
Blood cholesterol increased 66.58 10.40 326 252642 207686 90167793
Spinal deformity 66.27 10.40 42 252926 1199 90374280
Dental fistula 66.15 10.40 34 252934 643 90374836
C-reactive protein 65.48 10.40 6 252962 31361 90344118
Traumatic fracture 65.20 10.40 35 252933 726 90374753
Dry mouth 65.14 10.40 278 252690 183781 90191698
Vitamin D abnormal 65.08 10.40 23 252945 160 90375319
Injury associated with device 65.02 10.40 71 252897 4393 90371086
Vitamin D deficiency 64.61 10.40 148 252820 17408 90358071
Medication error 64.43 10.40 85 252883 84567 90290912
Therapeutic response decreased 64.39 10.40 94 252874 89635 90285844
Colitis ulcerative 63.91 10.40 45 252923 60221 90315258
Therapeutic product effect incomplete 63.73 10.40 301 252667 193595 90181884
Tooth resorption 63.49 10.40 17 252951 37 90375442
Hospice care 63.02 10.40 104 252864 9600 90365879
Urinary tract infection 62.78 10.40 1200 251768 304432 90071047
Liver function test increased 62.76 10.40 87 252881 84768 90290711
Therapy non-responder 62.72 10.40 185 252783 136519 90238960
Unevaluable event 62.56 10.40 311 252657 54537 90320942
Epilepsy 62.10 10.40 83 252885 82123 90293356
Dyspepsia 62.02 10.40 313 252655 197847 90177632
Encephalopathy 61.89 10.40 26 252942 46418 90329061
Periodontal disease 60.70 10.40 45 252923 1667 90373812
Cholesteatoma 60.49 10.40 22 252946 168 90375311
Hypoxia 60.06 10.40 68 252900 72331 90303148
Urticaria 59.74 10.40 571 252397 312163 90063316
Menopausal symptoms 59.46 10.40 57 252911 3021 90372458
International normalised ratio increased 59.13 10.40 29 252939 47287 90328192
Parathyroid tumour benign 58.44 10.40 35 252933 901 90374578
Dementia 57.81 10.40 172 252796 23689 90351790
Mouth swelling 57.60 10.40 75 252893 5587 90369892
Hyperparathyroidism secondary 56.48 10.40 44 252924 1757 90373722
Dental discomfort 56.37 10.40 28 252940 491 90374988
Lymphoedema 56.31 10.40 121 252847 13632 90361847
Coeliac disease 56.26 10.40 27 252941 44583 90330896
Polymyalgia rheumatica 55.49 10.40 69 252899 4908 90370571
Laryngitis 55.01 10.40 37 252931 50716 90324763
Living in residential institution 54.79 10.40 30 252938 648 90374831
Respiratory failure 54.51 10.40 160 252808 118258 90257221
Oxygen saturation decreased 54.13 10.40 139 252829 107344 90268135
Blood alkaline phosphatase decreased 53.23 10.40 40 252928 1513 90373966
Device failure 53.21 10.40 80 252888 6817 90368662
Cellulitis 52.96 10.40 436 252532 90901 90284578
Spinal operation 52.89 10.40 99 252869 10097 90365382
Metastasis 52.89 10.40 75 252893 6062 90369417
Respiratory arrest 52.49 10.40 14 252954 33297 90342182
Fluid retention 52.44 10.40 104 252864 87987 90287492
Dental prosthesis placement 52.38 10.40 16 252952 65 90375414
Oral infection 52.26 10.40 69 252899 5211 90370268
Product label confusion 51.62 10.40 3 252965 22847 90352632
Psychotic disorder 51.39 10.40 12 252956 31218 90344261
Parathyroidectomy 50.76 10.40 23 252945 325 90375154
Toxic epidermal necrolysis 50.63 10.40 14 252954 32514 90342965
Parathyroid disorder 50.48 10.40 30 252938 761 90374718
Gait inability 50.11 10.40 224 252744 146232 90229247
Incorrect dose administered 49.78 10.40 90 252878 78840 90296639
Onychomycosis 49.68 10.40 21 252947 37355 90338124
Hyponatraemia 49.54 10.40 198 252770 133340 90242139
Premature baby 49.27 10.40 6 252962 25071 90350408
Bone sequestrum 48.86 10.40 37 252931 1416 90374063
Bone giant cell tumour malignant 48.84 10.40 10 252958 0 90375479
Nausea 48.75 10.40 2569 250399 1107747 89267732
Dysarthria 48.74 10.40 48 252920 54434 90321045
Parathyroid tumour 48.66 10.40 18 252950 145 90375334
Ulna fracture 48.03 10.40 35 252933 1262 90374217
Hepatitis 47.97 10.40 77 252891 70662 90304817
Hepatic cirrhosis 47.64 10.40 64 252904 63189 90312290
Osteolysis 47.47 10.40 54 252914 3496 90371983
Intentional product misuse 47.37 10.40 113 252855 89491 90285988
Oedema peripheral 47.10 10.40 476 252492 257439 90118040
Red blood cell sedimentation rate abnormal 47.04 10.40 6 252962 24198 90351281
Drug level increased 47.02 10.40 10 252958 27752 90347727
Taste disorder 46.63 10.40 62 252906 61484 90313995
Trismus 46.18 10.40 62 252906 4759 90370720
Chest discomfort 45.92 10.40 214 252754 138151 90237328
Oral surgery 45.78 10.40 37 252931 1559 90373920
Ankle fracture 45.76 10.40 143 252825 20227 90355252
Wrong product administered 45.60 10.40 79 252889 7586 90367893
Frequent bowel movements 45.58 10.40 55 252913 56880 90318599
Haematochezia 45.49 10.40 80 252888 70833 90304646
Drug withdrawal syndrome 45.39 10.40 12 252956 28711 90346768
Oral discomfort 44.97 10.40 94 252874 10389 90365090
Dizziness 44.86 10.40 1277 251691 588007 89787472
Multiple organ dysfunction syndrome 44.84 10.40 76 252892 68260 90307219
Bone resorption test abnormal 44.16 10.40 10 252958 6 90375473
Breast cancer recurrent 44.13 10.40 65 252903 5438 90370041
Hot flush 44.13 10.40 301 252667 59187 90316292
Hormone receptor positive HER2 negative breast cancer 44.05 10.40 20 252948 284 90375195
Osteosclerosis 43.60 10.40 57 252911 4263 90371216
Pleural neoplasm 43.14 10.40 22 252946 409 90375070
Hypoglycaemia 42.84 10.40 81 252887 69767 90305712
Mental status changes 42.77 10.40 37 252931 44642 90330837
Oral cavity fistula 42.61 10.40 25 252943 619 90374860
Diverticulitis 42.51 10.40 243 252725 44944 90330535
Hungry bone syndrome 42 10.40 16 252952 141 90375338
Oestrogen deficiency 41.90 10.40 16 252952 142 90375337
Lichen planus 41.71 10.40 45 252923 2746 90372733
Rectal haemorrhage 41.66 10.40 107 252861 82637 90292842
Abdominal lymphadenopathy 41.29 10.40 29 252939 986 90374493
Sinus tachycardia 41.27 10.40 14 252954 28499 90346980
Bone graft 41.16 10.40 29 252939 991 90374488
Immune system disorder 40.15 10.40 97 252871 11808 90363671
Stomatitis 40.04 10.40 533 252435 274165 90101314
Hallucination 40.01 10.40 77 252891 65882 90309597
Generalised tonic-clonic seizure 39.81 10.40 24 252944 34879 90340600
Patella fracture 39.77 10.40 42 252926 2501 90372978
Eosinophilia 39.61 10.40 15 252953 28518 90346961
Refusal of treatment by patient 39.30 10.40 63 252905 5675 90369804
Hypoaesthesia oral 39.27 10.40 114 252854 15486 90359993
Rheumatoid nodule 39.19 10.40 5 252963 20161 90355318
Sedation 39.13 10.40 46 252922 48125 90327354
Infusion site reaction 38.80 10.40 4 252964 19035 90356444
Hyperparathyroidism primary 38.46 10.40 21 252947 451 90375028
Bone cancer 38.36 10.40 34 252934 1628 90373851
Device dislocation 38.28 10.40 20 252948 31462 90344017
Noninfective gingivitis 38.09 10.40 38 252930 2115 90373364
Forearm fracture 38.06 10.40 23 252945 602 90374877
Oral disorder 37.84 10.40 87 252881 10258 90365221
Metastases to peritoneum 37.62 10.40 52 252916 4103 90371376
Pustular psoriasis 37.56 10.40 4 252964 18552 90356927
Back injury 37.36 10.40 45 252923 46577 90328902
Kyphosis 36.81 10.40 43 252925 2865 90372614
Musculoskeletal disorder 36.80 10.40 139 252829 21630 90353849
Denture wearer 36.57 10.40 16 252952 207 90375272
Rhabdomyolysis 36.47 10.40 54 252914 51202 90324277
Sedation complication 36.03 10.40 3 252965 16941 90358538
Nerve compression 35.54 10.40 86 252882 10480 90364999
Pollakiuria 35.43 10.40 184 252784 32821 90342658
Disability 35.19 10.40 37 252931 40708 90334771
Osteoporosis 35.04 10.40 418 252550 96113 90279366
Alopecia 34.87 10.40 1084 251884 493987 89881492
Ulcer haemorrhage 34.64 10.40 15 252953 26306 90349173
Rash papular 34.43 10.40 130 252838 20225 90355254
Emotional distress 34.32 10.40 31 252937 36631 90338848
Loss of consciousness 34.08 10.40 240 252728 139998 90235481
Disease progression 33.87 10.40 620 252348 155995 90219484
Vitamin D increased 33.84 10.40 25 252943 921 90374558
Ear infection 33.78 10.40 92 252876 69683 90305796
Parathyroid hormone-related protein increased 33.55 10.40 8 252960 8 90375471
Drug tolerance 33.50 10.40 5 252963 17911 90357568
Female genital tract fistula 33.38 10.40 5 252963 17863 90357616
Gastrointestinal haemorrhage 33.35 10.40 134 252834 90114 90285365
Metastatic neoplasm 33.16 10.40 53 252915 4762 90370717
Caesarean section 32.92 10.40 6 252962 18571 90356908
Scab 32.56 10.40 79 252889 9642 90365837
Onychoclasis 32.51 10.40 67 252901 7332 90368147
White blood cell count increased 32.30 10.40 89 252879 67152 90308327
Intervertebral disc protrusion 32.29 10.40 156 252812 27040 90348439
Chronic sinusitis 32.24 10.40 13 252955 23789 90351690
Cytokine release syndrome 32.23 10.40 19 252949 27954 90347525
Cytomegalovirus infection 32.20 10.40 17 252951 26585 90348894
Seronegative arthritis 32.07 10.40 6 252962 18228 90357251
Neutrophil count decreased 32.06 10.40 323 252645 71209 90304270
Chemotherapy 31.87 10.40 32 252936 1795 90373684
Hepatic lesion 31.85 10.40 57 252911 5616 90369863
Vertigo 31.66 10.40 316 252652 69495 90305984
Affect lability 31.65 10.40 6 252962 18057 90357422
Heavy menstrual bleeding 31.65 10.40 9 252959 20521 90354958
Proctitis 31.64 10.40 3 252965 15256 90360223
Nail disorder 31.61 10.40 74 252894 58993 90316486
Status epilepticus 31.56 10.40 7 252961 18867 90356612
Hyperhidrosis 31.33 10.40 237 252731 136068 90239411
Streptococcal sepsis 31.18 10.40 44 252924 3540 90371939
Cataract operation 30.92 10.40 59 252909 6104 90369375
Metastases to adrenals 30.90 10.40 24 252944 954 90374525
Hemiparesis 30.88 10.40 26 252942 31793 90343686
Schizophrenia 30.74 10.40 3 252965 14911 90360568
Rotator cuff syndrome 30.60 10.40 106 252862 15813 90359666
Rash macular 30.58 10.40 166 252802 30114 90345365
Intercepted medication error 30.51 10.40 23 252945 874 90374605
Hyperkalaemia 30.46 10.40 87 252881 64877 90310602
Right ventricular failure 30.39 10.40 8 252960 19197 90356282
Cognitive disorder 30.35 10.40 96 252872 69311 90306168
Hip surgery 30.03 10.40 47 252921 4148 90371331
Visual impairment 30.02 10.40 231 252737 132134 90243345
Muscle tightness 29.87 10.40 94 252874 13345 90362134
Blood 25-hydroxycholecalciferol decreased 29.80 10.40 11 252957 88 90375391
Upper respiratory tract infection 29.54 10.40 223 252745 128095 90247384
Extrapyramidal disorder 29.47 10.40 5 252963 16298 90359181
Finger deformity 29.41 10.40 29 252939 32868 90342611
Metastases to bladder 29.23 10.40 14 252954 226 90375253
Obstructive airways disorder 29.21 10.40 18 252950 25851 90349628
Poisoning 29.03 10.40 4 252964 15213 90360266
Periprosthetic fracture 28.97 10.40 19 252949 576 90374903
Muscle atrophy 28.92 10.40 69 252899 8332 90367147
Flushing 28.69 10.40 138 252830 88353 90287126
Cancer pain 28.68 10.40 45 252923 3980 90371499
Mydriasis 28.51 10.40 4 252964 15008 90360471
Coordination abnormal 28.38 10.40 12 252956 21344 90354135
Tachypnoea 28.28 10.40 12 252956 21297 90354182
Clavicle fracture 28.21 10.40 44 252924 3872 90371607
Aggression 28.16 10.40 20 252948 26648 90348831
Respiratory disorder 28.09 10.40 90 252878 64726 90310753
Gingival erythema 28.08 10.40 24 252944 1094 90374385
Infusion site pain 28.03 10.40 10 252958 19728 90355751
Vertebroplasty 28.02 10.40 16 252952 376 90375103
Lung neoplasm malignant 27.94 10.40 138 252830 24135 90351344
Insomnia 27.84 10.40 713 252255 332761 90042718
Blood pressure decreased 27.80 10.40 111 252857 74784 90300695
Peri-implantitis 27.54 10.40 10 252958 76 90375403
Pancreatitis 27.53 10.40 101 252867 69725 90305754
Stevens-Johnson syndrome 27.31 10.40 25 252943 29351 90346128
Adrenal insufficiency 27.18 10.40 26 252942 29895 90345584
Dysstasia 27.12 10.40 140 252828 24912 90350567
Underdose 27.08 10.40 70 252898 53947 90321532
Gait disturbance 27.07 10.40 934 252034 259562 90115917
Food allergy 27.04 10.40 19 252949 25459 90350020
Gingival cyst 26.88 10.40 6 252962 3 90375476
Dental prosthesis user 26.88 10.40 9 252959 52 90375427
Drug reaction with eosinophilia and systemic symptoms 26.74 10.40 49 252919 42709 90332770
Tooth discolouration 26.65 10.40 24 252944 1174 90374305
Hallucination, auditory 26.56 10.40 6 252962 15969 90359510
Joint destruction 26.55 10.40 3 252965 13284 90362195
Abscess oral 26.45 10.40 27 252941 1545 90373934
Rehabilitation therapy 26.35 10.40 30 252938 1944 90373535
Monocytosis 26.33 10.40 22 252946 972 90374507
Cardiogenic shock 26.30 10.40 18 252950 24450 90351029
Metaphyseal corner fracture 26.29 10.40 8 252960 32 90375447
Gingival operation 26.20 10.40 12 252956 174 90375305
Limb discomfort 26.13 10.40 189 252779 37871 90337608
Varicose vein 26.12 10.40 61 252907 7266 90368213
Dysuria 26.10 10.40 194 252774 39207 90336272
Giant cell arteritis 26.08 10.40 37 252931 2992 90372487
Bone cancer metastatic 26.02 10.40 13 252955 231 90375248
Vascular device infection 26.02 10.40 83 252885 11869 90363610
Nasal congestion 25.94 10.40 132 252836 83282 90292197
Pulmonary arterial hypertension 25.91 10.40 21 252947 26166 90349313
Pain of skin 25.80 10.40 101 252867 15981 90359498
Vaginal discharge 25.76 10.40 11 252957 19453 90356026
Septic shock 25.71 10.40 134 252834 84026 90291453
Staphylococcal infection 25.67 10.40 61 252907 48378 90327101
Nephrolithiasis 25.66 10.40 229 252739 48856 90326623
Paranoia 25.58 10.40 3 252965 12905 90362574
Ventricular tachycardia 25.48 10.40 19 252949 24689 90350790
Gingival ulceration 25.39 10.40 22 252946 1022 90374457
Neoplasm 25.31 10.40 68 252900 8835 90366644
Transplant rejection 25.19 10.40 3 252965 12755 90362724
Hypercalciuria 25.19 10.40 15 252953 382 90375097
Fibroblast growth factor 23 increased 25.16 10.40 6 252962 6 90375473
Nail bed inflammation 25.11 10.40 28 252940 1773 90373706
Triple negative breast cancer 24.95 10.40 15 252953 389 90375090
Mastectomy 24.86 10.40 30 252938 2069 90373410
Calcinosis 24.81 10.40 34 252934 2661 90372818
Hypervolaemia 24.81 10.40 33 252935 32724 90342755
Weight bearing difficulty 24.75 10.40 35 252933 2821 90372658
Circulatory collapse 24.60 10.40 20 252948 24884 90350595
Disease recurrence 24.58 10.40 42 252926 37611 90337868
Syncope 24.55 10.40 244 252724 132419 90243060
Hair disorder 24.32 10.40 23 252945 1198 90374281
Blood pressure abnormal 24.28 10.40 114 252854 19531 90355948
Tremor 24.24 10.40 292 252676 152881 90222598
Metastases to meninges 24.21 10.40 40 252928 3695 90371784
Injection site erythema 24.21 10.40 168 252800 98334 90277145
Product substitution issue 24.12 10.40 10 252958 17998 90357481
Breast disorder 24.12 10.40 34 252934 2733 90372746
Pleural effusion 24.09 10.40 443 252525 111548 90263931
Carbohydrate antigen 27.29 increased 24.06 10.40 10 252958 113 90375366
Bone swelling 24.04 10.40 27 252941 1724 90373755
Irritability 24.01 10.40 39 252929 35623 90339856
Acute myeloid leukaemia 23.81 10.40 14 252954 20626 90354853
Foot deformity 23.70 10.40 86 252882 59565 90315914
Paronychia 23.62 10.40 62 252906 7944 90367535
Invasive ductal breast carcinoma 23.53 10.40 61 252907 7757 90367722
Cataract 23.51 10.40 306 252662 71786 90303693
Memory impairment 23.46 10.40 398 252570 196846 90178633
Malpositioned teeth 23.41 10.40 7 252961 26 90375453
Nightmare 23.33 10.40 16 252952 21709 90353770
Abortion induced 22.97 10.40 3 252965 11885 90363594
Dysgeusia 22.92 10.40 236 252732 52324 90323155
Agranulocytosis 22.89 10.40 39 252929 34963 90340516
Nasal mucosal disorder 22.75 10.40 27 252941 1830 90373649
Dyskinesia 22.73 10.40 42 252926 36492 90338987
Cyanosis 22.72 10.40 13 252955 19442 90356037
Coagulopathy 22.64 10.40 19 252949 23270 90352209
Leukopenia 22.58 10.40 401 252567 100309 90275170
Oral mucosal erythema 22.45 10.40 26 252942 1716 90373763
Cervical vertebral fracture 22.34 10.40 36 252932 3257 90372222
Bone metabolism biochemical marker increased 22.25 10.40 7 252961 32 90375447
Neuroglycopenia 22.21 10.40 21 252947 1094 90374385
Neck pain 22.19 10.40 444 252524 113519 90261960
Osteomalacia 22.05 10.40 19 252949 876 90374603
Blood cholesterol decreased 21.90 10.40 27 252941 1904 90373575
Fibula fracture 21.80 10.40 41 252927 4196 90371283
Spinal disorder 21.79 10.40 77 252891 11602 90363877
Gingival injury 21.74 10.40 7 252961 35 90375444
Acetabulum fracture 21.74 10.40 14 252954 411 90375068
Thyroid operation 21.74 10.40 11 252957 201 90375278
Drug resistance 21.74 10.40 32 252936 30417 90345062
Skin disorder 21.69 10.40 176 252792 36530 90338949
Hepatic cyst 21.60 10.40 53 252915 6515 90368964
Breath sounds abnormal 21.51 10.40 8 252960 15378 90360101
Heart rate decreased 21.35 10.40 77 252891 53428 90322051
Metastases to bone marrow 21.34 10.40 16 252952 603 90374876
Bone infarction 21.30 10.40 14 252954 426 90375053
Osteochondrosis 21.27 10.40 26 252942 1817 90373662
Product prescribing error 21.21 10.40 32 252936 30113 90345366
Angioedema 21.13 10.40 101 252867 64775 90310704
Akathisia 21.13 10.40 3 252965 11156 90364323
Photophobia 21.11 10.40 17 252951 21252 90354227
Blood creatinine abnormal 21.11 10.40 40 252928 4117 90371362
Accidental overdose 20.89 10.40 29 252939 28244 90347235
Bone marrow oedema 20.84 10.40 23 252945 1440 90374039
Tubulointerstitial nephritis 20.80 10.40 24 252944 25319 90350160
Posterior reversible encephalopathy syndrome 20.78 10.40 19 252949 22320 90353159
Peripheral circulatory failure 20.78 10.40 24 252944 1580 90373899
Erysipelas 20.75 10.40 64 252904 8988 90366491
Hyperlipidaemia 20.75 10.40 122 252846 22794 90352685
Thyroid mass 20.66 10.40 46 252922 5309 90370170
Acute respiratory distress syndrome 20.62 10.40 30 252938 28656 90346823
Burning sensation 20.55 10.40 269 252699 63183 90312296
Tumour marker abnormal 20.52 10.40 13 252955 371 90375108
Dental paraesthesia 20.50 10.40 5 252963 6 90375473
Nasal polyps 20.43 10.40 3 252965 10877 90364602
Bronchitis 20.39 10.40 302 252666 152625 90222854
VIth nerve paresis 20.38 10.40 8 252960 77 90375402
Vertebral wedging 20.34 10.40 6 252962 21 90375458
Amenorrhoea 20.31 10.40 4 252964 11718 90363761
Respiratory depression 20.30 10.40 9 252959 15566 90359913
Vertebral lesion 20.27 10.40 17 252951 755 90374724
Activated PI3 kinase delta syndrome 20.11 10.40 8 252960 80 90375399
CYP3A4 polymorphism 20.11 10.40 8 252960 80 90375399
Blood magnesium decreased 20.08 10.40 92 252876 15601 90359878
Oral neoplasm benign 20.06 10.40 5 252963 7 90375472
Personality disorder 20.05 10.40 5 252963 12439 90363040
Haematemesis 19.91 10.40 40 252928 33686 90341793
Second primary malignancy 19.86 10.40 69 252899 10309 90365170
Bone density increased 19.81 10.40 18 252950 891 90374588
Vaccination site reaction 19.75 10.40 11 252957 246 90375233
Bone deformity 19.74 10.40 15 252953 577 90374902
Respiratory rate increased 19.70 10.40 10 252958 15991 90359488
Labelled drug-drug interaction medication error 19.69 10.40 8 252960 14574 90360905
Hypomagnesaemia 19.62 10.40 168 252800 35420 90340059
Orthostatic hypotension 19.62 10.40 56 252912 41771 90333708
Bacteraemia 19.54 10.40 20 252948 22280 90353199
Serum procollagen type I N-terminal propeptide decreased 19.54 10.40 4 252964 0 90375479
Impaired healing 19.46 10.40 501 252467 233698 90141781
Oroantral fistula 19.41 10.40 10 252958 190 90375289
Panniculitis 19.41 10.40 8 252960 14450 90361029
Osteocalcin decreased 19.41 10.40 7 252961 52 90375427
Root canal infection 19.37 10.40 13 252955 410 90375069
Hypercalcaemia of malignancy 19.32 10.40 11 252957 257 90375222
Complication of device insertion 19.31 10.40 3 252965 10433 90365046
Radiation fibrosis - lung 19.30 10.40 7 252961 53 90375426
Blood 1,25-dihydroxycholecalciferol increased 19.30 10.40 7 252961 53 90375426
Joint dislocation 19.25 10.40 62 252906 44520 90330959
Macule 19.24 10.40 30 252938 2639 90372840
Mouth ulceration 19.13 10.40 183 252785 39791 90335688
Pneumonia aspiration 19.06 10.40 55 252913 40885 90334594
Hyperthermia 19.06 10.40 3 252965 10332 90365147
Osteosarcoma 18.86 10.40 9 252959 144 90375335
Breast pain 18.85 10.40 68 252900 10350 90365129
Withdrawal syndrome 18.85 10.40 21 252947 22503 90352976
Eastern Cooperative Oncology Group performance status worsened 18.67 10.40 25 252943 1914 90373565
Fistula 18.65 10.40 75 252893 12014 90363465
Anuria 18.64 10.40 9 252959 14809 90360670
Injection site pruritus 18.61 10.40 82 252886 53752 90321727
Ventricular fibrillation 18.49 10.40 8 252960 14036 90361443
Orthodontic procedure 18.34 10.40 5 252963 12 90375467
General symptom 18.31 10.40 9 252959 14659 90360820
Cerebrovascular accident 18.30 10.40 463 252505 123070 90252409
White blood cell disorder 18.22 10.40 31 252937 2933 90372546
Palliative care 18.21 10.40 17 252951 871 90374608
Myoclonus 18.19 10.40 16 252952 19152 90356327
Adjusted calcium decreased 18.18 10.40 10 252958 218 90375261
Polyneuropathy 18.18 10.40 104 252864 19237 90356242
Illness 18.14 10.40 144 252824 81825 90293654
Delusion 18.04 10.40 8 252960 13832 90361647
Pancytopenia 18.00 10.40 232 252736 120031 90255448
Drug dependence 17.99 10.40 34 252934 29293 90346186
Abnormal behaviour 17.96 10.40 22 252946 22606 90352873
Heart rate increased 17.95 10.40 215 252753 112687 90262792
Invasive lobular breast carcinoma 17.91 10.40 18 252950 1011 90374468
Gastroenteritis radiation 17.89 10.40 14 252954 563 90374916
Rales 17.89 10.40 11 252957 15816 90359663
Malaise 17.81 10.40 1401 251567 584585 89790894
Cholecystitis chronic 17.79 10.40 3 252965 9823 90365656
Pseudomonal sepsis 17.79 10.40 38 252930 4264 90371215
Metastases to gastrointestinal tract 17.79 10.40 8 252960 111 90375368
Mucosal inflammation 17.71 10.40 242 252726 57383 90318096
Creatinine renal clearance decreased 17.67 10.40 16 252952 18883 90356596
Tumour pain 17.67 10.40 24 252944 1863 90373616
Respiratory distress 17.64 10.40 53 252915 38893 90336586
Sternal fracture 17.49 10.40 30 252938 2857 90372622
Aphasia 17.49 10.40 61 252907 42751 90332728
Gingival discolouration 17.42 10.40 11 252957 312 90375167
Body temperature increased 17.41 10.40 65 252903 44645 90330834
Immunodeficiency 17.39 10.40 62 252906 43172 90332307
Pancreatitis acute 17.37 10.40 40 252928 32075 90343404
Hypothermia 17.36 10.40 11 252957 15564 90359915
Inguinal hernia repair 17.26 10.40 7 252961 74 90375405
Liver function test abnormal 17.24 10.40 78 252890 50767 90324712
Acidosis 17.18 10.40 7 252961 12729 90362750
Blood pressure increased 17.16 10.40 419 252549 196798 90178681
Pulmonary hypertension 17.09 10.40 61 252907 42462 90333017
Allergy to plants 17.07 10.40 16 252952 824 90374655
Neuropathy peripheral 17.06 10.40 502 252466 136468 90239011
Granuloma annulare 17.01 10.40 16 252952 828 90374651
Hypoaesthesia teeth 16.95 10.40 6 252962 42 90375437
Cardiac failure congestive 16.84 10.40 185 252783 98509 90276970
Renal impairment 16.78 10.40 399 252569 105022 90270457
Tartrate-resistant acid phosphatase increased 16.78 10.40 4 252964 4 90375475
Hypercalcaemic nephropathy 16.78 10.40 4 252964 4 90375475
Medial tibial stress syndrome 16.76 10.40 8 252960 128 90375351
Pelvic pain 16.75 10.40 86 252882 15271 90360208
Ejection fraction decreased 16.68 10.40 128 252840 26125 90349354
Bronchospasm 16.58 10.40 20 252948 20689 90354790
Adnexa uteri mass 16.50 10.40 14 252954 632 90374847
Enchondromatosis 16.49 10.40 8 252960 133 90375346
Bone scan abnormal 16.46 10.40 12 252956 433 90375046
Haematoma 16.38 10.40 55 252913 38993 90336486
Malocclusion 16.38 10.40 8 252960 135 90375344
Aspartate aminotransferase increased 16.37 10.40 196 252772 102741 90272738
Alanine aminotransferase increased 16.37 10.40 232 252736 118106 90257373
Intermenstrual bleeding 16.30 10.40 3 252965 9220 90366259
Metastases to the mediastinum 16.29 10.40 14 252954 643 90374836
Sinus bradycardia 16.27 10.40 14 252954 16938 90358541
Macular degeneration 16.26 10.40 53 252915 37917 90337562
Aspergillus infection 16.22 10.40 5 252963 10818 90364661
Tooth deposit 16.21 10.40 10 252958 272 90375207
Disturbance in attention 16.14 10.40 72 252896 47037 90328442
Pulmonary tumour thrombotic microangiopathy 16.11 10.40 7 252961 89 90375390
Device malfunction 16.02 10.40 21 252947 20956 90354523
Sputum discoloured 16.00 10.40 20 252948 20371 90355108
Metastases to spinal cord 15.92 10.40 10 252958 281 90375198
Angina pectoris 15.86 10.40 56 252912 39104 90336375
Sinus congestion 15.79 10.40 33 252935 27391 90348088
Spondylolisthesis 15.72 10.40 35 252933 4040 90371439
Dermo-hypodermitis 15.69 10.40 15 252953 792 90374687
Hepatic cancer 15.64 10.40 39 252929 4842 90370637
Dental cyst 15.64 10.40 6 252962 54 90375425
Scapula fracture 15.60 10.40 12 252956 470 90375009
Carbohydrate antigen 15-3 15.57 10.40 7 252961 97 90375382
Papillary thyroid cancer 15.53 10.40 27 252941 2600 90372879
Drug level decreased 15.50 10.40 4 252964 9726 90365753
Product communication issue 15.45 10.40 20 252948 1481 90373998
Oral pustule 15.45 10.40 6 252962 56 90375423
Shock 15.44 10.40 36 252932 28742 90346737
Tumour invasion 15.40 10.40 10 252958 298 90375181
Ear disorder 15.38 10.40 38 252930 4692 90370787
Gas gangrene 15.30 10.40 8 252960 157 90375322
Adjustment disorder 15.29 10.40 4 252964 9638 90365841
Renal tubular necrosis 15.26 10.40 11 252957 14544 90360935
Surgery 15.26 10.40 192 252776 44695 90330784
Pleural disorder 15.25 10.40 14 252954 702 90374777
Breast cancer stage I 15.25 10.40 4 252964 9620 90365859
Micturition urgency 15.23 10.40 67 252901 11166 90364313
Encephalitis 15.21 10.40 6 252962 11128 90364351
Facial pain 15.21 10.40 75 252893 13107 90362372
Bruxism 15.20 10.40 36 252932 4327 90371152
Device fastener issue 15.19 10.40 7 252961 103 90375376
Malabsorption 15.17 10.40 40 252928 5138 90370341
Lumbar spinal stenosis 15.16 10.40 42 252926 5555 90369924
Epstein-Barr virus infection 15.11 10.40 5 252963 10339 90365140
Brachiocephalic vein thrombosis 15.07 10.40 7 252961 105 90375374
Dental plaque 15.07 10.40 7 252961 105 90375374
Skin necrosis 15.07 10.40 15 252953 16926 90358553
Osteosarcoma recurrent 15.06 10.40 5 252963 28 90375451
Nail discolouration 15.01 10.40 30 252938 3212 90372267
Eye injury 14.95 10.40 6 252962 11014 90364465
Haematotoxicity 14.95 10.40 72 252896 12463 90363016
Retinal operation 14.92 10.40 5 252963 29 90375450
Blood creatine phosphokinase increased 14.91 10.40 47 252921 33976 90341503
Blood cholesterol abnormal 14.91 10.40 28 252940 2862 90372617
Ataxia 14.90 10.40 17 252951 18025 90357454
Osteoarthritis 14.88 10.40 424 252544 195306 90180173
Chronic leukaemia 14.85 10.40 4 252964 9 90375470
Carcinoid tumour pulmonary 14.80 10.40 12 252956 508 90374971
Bone neoplasm 14.80 10.40 15 252953 851 90374628
Mucosal pain 14.77 10.40 5 252963 30 90375449
Gingival atrophy 14.77 10.40 5 252963 30 90375449
Disorientation 14.76 10.40 68 252900 44046 90331433
Muscle disorder 14.73 10.40 41 252927 5438 90370041
Acute phase reaction 14.71 10.40 10 252958 322 90375157
Dysphagia 14.67 10.40 414 252554 111864 90263615
Sinus perforation 14.65 10.40 3 252965 0 90375479
C-telopeptide decreased 14.65 10.40 3 252965 0 90375479
Masticatory pain 14.65 10.40 3 252965 0 90375479
C-telopeptide 14.65 10.40 3 252965 0 90375479
Adenoid cystic carcinoma 14.64 10.40 5 252963 31 90375448
Parathyroid gland operation 14.64 10.40 5 252963 31 90375448
Metastases to uterus 14.61 10.40 7 252961 113 90375366
Plantar fasciitis 14.60 10.40 35 252933 4239 90371240
Hypoacusis 14.59 10.40 130 252838 27720 90347759
Bone fistula 14.58 10.40 6 252962 66 90375413
Pancreatogenous diabetes 14.55 10.40 4 252964 10 90375469
Blood phosphorus abnormal 14.52 10.40 8 252960 175 90375304
Onychalgia 14.50 10.40 17 252951 1137 90374342
Acute coronary syndrome 14.49 10.40 6 252962 10807 90364672
Gangrene 14.48 10.40 9 252959 12867 90362612
Acute respiratory failure 14.46 10.40 66 252902 42852 90332627
Intervertebral disc degeneration 14.39 10.40 90 252878 17184 90358295
Lip exfoliation 14.39 10.40 14 252954 756 90374723
Hypocalcaemic seizure 14.37 10.40 5 252963 33 90375446
Diabetic ketoacidosis 14.36 10.40 29 252939 24378 90351101
Psychomotor hyperactivity 14.35 10.40 9 252959 12804 90362675
Bronchopulmonary aspergillosis 14.22 10.40 7 252961 11391 90364088
Pre-existing condition improved 14.17 10.40 4 252964 9165 90366314
Leukocytosis 14.16 10.40 42 252926 30948 90344531
Tachyphylaxis 14.16 10.40 10 252958 343 90375136
Panic attack 14.13 10.40 33 252935 26332 90349147
Cardiac murmur 14.12 10.40 18 252950 18176 90357303
Skin irritation 14.03 10.40 75 252893 13528 90361951
Virilism foetal 14.03 10.40 4 252964 12 90375467
Haemoptysis 13.93 10.40 47 252921 33273 90342206
Bone marrow failure 13.78 10.40 45 252923 32176 90343303
Progressive multifocal leukoencephalopathy 13.76 10.40 14 252954 15641 90359838
Urine calcium increased 13.76 10.40 6 252962 77 90375402
Respiratory syncytial virus infection 13.75 10.40 6 252962 10474 90365005
Pallor 13.74 10.40 49 252919 34116 90341363
Gastrointestinal bacterial infection 13.72 10.40 16 252952 1064 90374415
Ankylosing spondylitis 13.67 10.40 10 252958 13123 90362356
Graft versus host disease 13.66 10.40 3 252965 8141 90367338
Bronchiectasis 13.60 10.40 26 252942 22304 90353175
Hemiplegia 13.59 10.40 15 252953 16145 90359334
Degenerative bone disease 13.54 10.40 9 252959 279 90375200
Lower gastrointestinal haemorrhage 13.52 10.40 4 252964 8888 90366591
Spinal cord compression 13.45 10.40 37 252931 4874 90370605
Open fracture 13.42 10.40 11 252957 473 90375006
Infusion site extravasation 13.41 10.40 6 252962 10322 90365157
Lymphoma 13.38 10.40 74 252894 13517 90361962
Ear pain 13.38 10.40 231 252737 57471 90318008
Immune-mediated lung disease 13.37 10.40 21 252947 1859 90373620
Blood 1,25-dihydroxycholecalciferol decreased 13.35 10.40 4 252964 15 90375464
Bone marrow infiltration 13.33 10.40 14 252954 828 90374651
Pneumocystis jirovecii pneumonia 13.31 10.40 25 252943 21591 90353888
Gingival bleeding 13.27 10.40 79 252889 14824 90360655
Nail growth abnormal 13.27 10.40 12 252956 590 90374889
Tardive dyskinesia 13.21 10.40 7 252961 10923 90364556
Shock haemorrhagic 13.17 10.40 9 252959 12236 90363243
Knee operation 13.17 10.40 46 252922 6890 90368589
Metastases to neck 13.16 10.40 6 252962 86 90375393
Periprosthetic metallosis 13.14 10.40 4 252964 16 90375463
Jaw cyst 13.14 10.40 7 252961 143 90375336
Hemianopia 13.10 10.40 22 252946 2060 90373419
Toxic encephalopathy 13.07 10.40 4 252964 8695 90366784
Skin mass 13.02 10.40 48 252920 7382 90368097
Metastases to vagina 12.95 10.40 4 252964 17 90375462
Conjunctival haemorrhage 12.94 10.40 32 252936 3952 90371527
Mean cell volume increased 12.94 10.40 37 252931 4984 90370495
Periumbilical abscess 12.92 10.40 8 252960 219 90375260
Sensory loss 12.90 10.40 19 252949 18056 90357423
Skin sensitisation 12.83 10.40 15 252953 1000 90374479
Altered state of consciousness 12.83 10.40 45 252923 31487 90343992
Carcinoembryonic antigen 12.80 10.40 6 252962 92 90375387
Ilium fracture 12.79 10.40 7 252961 151 90375328
Catheter site injury 12.79 10.40 9 252959 307 90375172
Oligodipsia 12.75 10.40 5 252963 48 90375431
Purulence 12.72 10.40 19 252949 1610 90373869
Aplastic anaemia 12.68 10.40 11 252957 13258 90362221
High turnover osteopathy 12.66 10.40 5 252963 49 90375430
Respiratory tract congestion 12.63 10.40 37 252931 27373 90348106
Urethritis noninfective 12.59 10.40 4 252964 19 90375460
Injected limb mobility decreased 12.59 10.40 4 252964 19 90375460
Extradural neoplasm 12.58 10.40 3 252965 3 90375476
Phosphaturic mesenchymal tumour 12.58 10.40 3 252965 3 90375476
Joint deposit 12.58 10.40 3 252965 3 90375476
Oliguria 12.55 10.40 7 252961 10617 90364862
Chondropathy 12.54 10.40 24 252944 2488 90372991
Injection site haemorrhage 12.50 10.40 39 252929 28279 90347200
Ovarian disorder 12.47 10.40 14 252954 893 90374586
Colitis 12.37 10.40 130 252838 69812 90305667
Bladder cancer 12.37 10.40 40 252928 5761 90369718
Polyglandular autoimmune syndrome type II 12.31 10.40 5 252963 53 90375426
Haemophagocytic lymphohistiocytosis 12.30 10.40 15 252953 15444 90360035
Lip and/or oral cavity cancer 12.29 10.40 14 252954 908 90374571
Sarcoma 12.27 10.40 12 252956 652 90374827
Hypovolaemia 12.26 10.40 10 252958 12421 90363058
Oral lichen planus 12.26 10.40 13 252955 778 90374701
Mood altered 12.26 10.40 18 252950 17126 90358353
Extraskeletal ossification 12.16 10.40 7 252961 167 90375312
Metastases to chest wall 12.16 10.40 12 252956 659 90374820
Neuralgia 12.14 10.40 138 252830 31362 90344117
Leukaemia 12.11 10.40 36 252932 4956 90370523
Basal cell carcinoma 12.07 10.40 50 252918 33339 90342140
Blood glucose increased 12.04 10.40 190 252778 95056 90280423
Weight fluctuation 12.02 10.40 23 252945 19726 90355753
Blood glucose decreased 12.02 10.40 30 252938 23399 90352080
Atrial septal defect 11.99 10.40 4 252964 8230 90367249
Paraganglion neoplasm 11.96 10.40 4 252964 23 90375456
Dental alveolar anomaly 11.84 10.40 5 252963 59 90375420
Autoimmune lung disease 11.79 10.40 6 252962 111 90375368
Demyelination 11.77 10.40 4 252964 8136 90367343
Bile duct stenosis 11.76 10.40 19 252949 1723 90373756
Deafness 11.75 10.40 105 252863 22409 90353070
Intervertebral disc calcification 11.72 10.40 3 252965 5 90375474
Exposure to SARS-CoV-2 11.72 10.40 23 252945 2429 90373050
Periarthritis 11.62 10.40 26 252942 3011 90372468
Oral mucosal discolouration 11.60 10.40 9 252959 357 90375122
Oophorectomy bilateral 11.56 10.40 6 252962 116 90375363
Cardiac disorder 11.55 10.40 223 252745 56649 90318830
Oral mucosal blistering 11.53 10.40 44 252924 6880 90368599
Tumour flare 11.44 10.40 11 252957 585 90374894
Varicophlebitis 11.42 10.40 4 252964 27 90375452
Naevus haemorrhage 11.42 10.40 6 252962 119 90375360
Ulcer 11.42 10.40 50 252918 32832 90342647
Spinal laminectomy 11.41 10.40 13 252955 843 90374636
Exposure to toxic agent 11.38 10.40 4 252964 7963 90367516
N-telopeptide urine decreased 11.37 10.40 3 252965 6 90375473
Oophorectomy 11.36 10.40 12 252956 715 90374764
Tumour necrosis 11.36 10.40 14 252954 987 90374492
Nail bed tenderness 11.35 10.40 9 252959 369 90375110
Pancreatic toxicity 11.34 10.40 5 252963 66 90375413
Tumour marker decreased 11.34 10.40 5 252963 66 90375413
Callus formation delayed 11.30 10.40 4 252964 28 90375451
Cholelithiasis 11.27 10.40 93 252875 52413 90323066
Gastroenteritis viral 11.26 10.40 45 252923 30310 90345169
Acute generalised exanthematous pustulosis 11.22 10.40 13 252955 13690 90361789
Palpitations 11.22 10.40 293 252675 136435 90239044
Ludwig angina 11.21 10.40 5 252963 68 90375411
Therapeutic response shortened 11.20 10.40 30 252938 22849 90352630
Stress 11.10 10.40 160 252808 81235 90294244
Wisdom teeth removal 11.10 10.40 12 252956 734 90374745
Hepatitis cholestatic 11.08 10.40 5 252963 8556 90366923
Claudication of jaw muscles 11.08 10.40 5 252963 70 90375409
Calcium deficiency 11.06 10.40 16 252952 1317 90374162
Erythroblast count increased 11.06 10.40 3 252965 7 90375472
Hypoaesthesia 11.01 10.40 742 252226 313468 90062011
Hydrothorax 11.01 10.40 14 252954 1019 90374460
Affective disorder 10.98 10.40 4 252964 7789 90367690
Lymphangiosis carcinomatosa 10.97 10.40 18 252950 1654 90373825
Device loosening 10.96 10.40 13 252955 880 90374599
Escherichia urinary tract infection 10.90 10.40 71 252897 13744 90361735
Carbohydrate antigen 19-9 increased 10.89 10.40 8 252960 292 90375187
Hypermetabolism 10.87 10.40 8 252960 293 90375186
Complement factor C4 decreased 10.82 10.40 8 252960 295 90375184
Vascular fragility 10.80 10.40 7 252961 208 90375271
Lichen sclerosus 10.79 10.40 16 252952 1347 90374132
Deafness unilateral 10.77 10.40 27 252941 3364 90372115
Apathy 10.74 10.40 9 252959 11031 90364448
SAPHO syndrome 10.74 10.40 6 252962 135 90375344
Bone operation 10.68 10.40 8 252960 301 90375178
Endometrial cancer metastatic 10.66 10.40 6 252962 137 90375342
Vascular operation 10.66 10.40 6 252962 137 90375342
Atrophic vulvovaginitis 10.64 10.40 19 252949 1868 90373611
Squamous cell carcinoma 10.63 10.40 56 252912 10045 90365434
Spinal stenosis 10.54 10.40 84 252884 17340 90358139
Adjusted calcium increased 10.53 10.40 4 252964 35 90375444
Complement factor C3 decreased 10.52 10.40 8 252960 308 90375171
Maxillofacial operation 10.52 10.40 3 252965 9 90375470
Atelectasis 10.50 10.40 34 252934 24375 90351104
Paraesthesia 10.48 10.40 823 252145 249503 90125976
Rosacea 10.44 10.40 38 252930 5809 90369670
Dry throat 10.43 10.40 47 252921 7913 90367566
Avulsion fracture 10.43 10.40 8 252960 312 90375167
Reflux gastritis 10.43 10.40 16 252952 1388 90374091

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 8280.13 13.49 2303 51411 16746 42550875
Off label use 2807.34 13.49 3685 50029 634650 41932971
Hypocalcaemia 2296.48 13.49 994 52720 29179 42538442
Death 1735.41 13.49 2509 51205 468676 42098945
Terminal state 547.17 13.49 207 53507 4216 42563405
Prostatic specific antigen increased 475.81 13.49 285 53429 16640 42550981
Metastases to bone 473.34 13.49 271 53443 14538 42553083
Malignant neoplasm progression 364.08 13.49 557 53157 107843 42459778
Tooth disorder 329.60 13.49 199 53515 11780 42555841
Tooth extraction 306.56 13.49 146 53568 5334 42562287
Bone pain 275.11 13.49 233 53481 23559 42544062
Atypical femur fracture 268.53 13.49 67 53647 291 42567330
Investigation 246.07 13.49 77 53637 858 42566763
Blood parathyroid hormone increased 244.88 13.49 92 53622 1835 42565786
Pain in jaw 243.40 13.49 177 53537 14325 42553296
Prostate cancer metastatic 224.39 13.49 126 53588 6503 42561118
Blood calcium decreased 222.30 13.49 151 53563 10957 42556664
Hypophosphataemia 219.62 13.49 194 53520 20751 42546870
Hypercalcaemia 202.91 13.49 174 53540 17884 42549737
Exposed bone in jaw 191.56 13.49 73 53641 1516 42566105
Hospitalisation 179.75 13.49 330 53384 74000 42493621
Drug ineffective 168.56 13.49 339 53375 629858 41937763
Toxicity to various agents 153.39 13.49 49 53665 229087 42338534
Jaw disorder 147.98 13.49 66 53648 2067 42565554
Osteomyelitis 132.56 13.49 138 53576 18085 42549536
Metastases to lung 132.25 13.49 112 53602 11312 42556309
Prostate cancer 129.73 13.49 215 53499 44428 42523193
Osteitis 122.31 13.49 54 53660 1650 42565971
Metastases to lymph nodes 118.72 13.49 81 53633 5917 42561704
Toothache 114.77 13.49 87 53627 7496 42560125
Pathological fracture 113.20 13.49 75 53639 5218 42562403
Delusion of grandeur 111.07 13.49 53 53661 1943 42565678
Occupational exposure to product 106.74 13.49 34 53680 403 42567218
Condition aggravated 106.60 13.49 103 53611 260651 42306970
Drug interaction 106.24 13.49 108 53606 266891 42300730
Completed suicide 104.04 13.49 4 53710 96461 42471160
Spinal fracture 100.07 13.49 87 53627 9103 42558518
Hormone-refractory prostate cancer 99.42 13.49 40 53674 964 42566657
Bone density abnormal 96.66 13.49 25 53689 129 42567492
Rhinalgia 93.67 13.49 46 53668 1798 42565823
Dental care 91.02 13.49 29 53685 344 42567277
Hot flush 91.02 13.49 126 53588 22225 42545396
Lymphocyte count abnormal 89.08 13.49 47 53667 2140 42565481
Metastases to liver 85.15 13.49 104 53610 16222 42551399
Hypotension 84.64 13.49 121 53593 257510 42310111
Tooth fracture 79.26 13.49 55 53659 4129 42563492
Back pain 79.09 13.49 371 53343 141405 42426216
Abscess jaw 75.11 13.49 30 53684 709 42566912
Osteonecrosis 74.66 13.49 96 53618 15769 42551852
Impaired healing 73.77 13.49 99 53615 16954 42550667
Intercepted product administration error 72.35 13.49 27 53687 528 42567093
Cardiac arrest 70.22 13.49 25 53689 109295 42458326
Cancer pain 70.19 13.49 48 53666 3519 42564102
Femur fracture 69.01 13.49 73 53641 9739 42557882
Affective disorder 66.05 13.49 57 53657 5903 42561718
Metastasis 62.55 13.49 50 53664 4655 42562966
Blood calcium abnormal 61.26 13.49 26 53688 720 42566901
Fatigue 59.89 13.49 823 52891 434818 42132803
Acute kidney injury 59.33 13.49 250 53464 367087 42200534
Bone density decreased 58.99 13.49 36 53678 2170 42565451
Blood phosphorus decreased 58.33 13.49 43 53671 3550 42564071
Decreased appetite 56.72 13.49 427 53287 192710 42374911
Fracture 56.48 13.49 60 53654 8043 42559578
Tooth loss 54.92 13.49 44 53670 4110 42563511
Dental caries 54.82 13.49 47 53667 4825 42562796
Parathyroid tumour malignant 54.49 13.49 14 53700 70 42567551
Jaw operation 54.11 13.49 17 53697 192 42567429
Drug hypersensitivity 53.91 13.49 29 53685 99360 42468261
Dental implantation 52.93 13.49 14 53700 80 42567541
Drug effective for unapproved indication 51.43 13.49 52 53662 6581 42561040
Thoracic vertebral fracture 49.55 13.49 33 53681 2315 42565306
Neoplasm progression 47.80 13.49 110 53604 28890 42538731
Bradycardia 47.76 13.49 24 53690 85460 42482161
Metastases to central nervous system 47.69 13.49 62 53652 10293 42557328
Suture rupture 47.18 13.49 19 53695 459 42567162
SARS-CoV-2 test positive 46.98 13.49 55 53659 8205 42559416
Hungry bone syndrome 46.70 13.49 15 53699 183 42567438
Exostosis of jaw 46.53 13.49 13 53701 94 42567527
Alopecia 46.02 13.49 109 53605 29167 42538454
Product storage error 45.64 13.49 63 53651 11077 42556544
Bone giant cell tumour malignant 45.42 13.49 8 53706 0 42567621
Accidental exposure to product 44.82 13.49 87 53627 20306 42547315
Bone lesion 44.31 13.49 36 53678 3430 42564191
Agitation 44.30 13.49 13 53701 64301 42503320
Peri-implantitis 43.93 13.49 13 53701 118 42567503
Endodontic procedure 43.79 13.49 19 53695 556 42567065
Tachycardia 43.50 13.49 38 53676 101049 42466572
Product use in unapproved indication 43.37 13.49 106 53608 184350 42383271
Tetany 42.38 13.49 23 53691 1109 42566512
Hip fracture 41.98 13.49 67 53647 13405 42554216
Stress fracture 41.89 13.49 22 53692 992 42566629
Asthma 40.43 13.49 14 53700 62300 42505321
Coma 40.39 13.49 9 53705 53545 42514076
Atypical fracture 39.72 13.49 13 53701 169 42567452
Soft tissue disorder 39.52 13.49 20 53694 834 42566787
Gastrointestinal haemorrhage 39.38 13.49 39 53675 97687 42469934
Loose tooth 38.40 13.49 22 53692 1179 42566442
Acetabulum fracture 37.94 13.49 16 53698 436 42567185
Schizophrenia 37.84 13.49 56 53658 10494 42557127
Jaw fistula 37.68 13.49 10 53704 58 42567563
Bone disorder 37.56 13.49 44 53670 6569 42561052
Artificial crown procedure 37.35 13.49 8 53706 14 42567607
Metastases to spine 37.33 13.49 31 53683 3046 42564575
Polyneuropathy in malignant disease 37.30 13.49 15 53699 361 42567260
Neuropathy peripheral 36.80 13.49 237 53477 101616 42466005
Tooth abscess 36.73 13.49 44 53670 6724 42560897
Multiple organ dysfunction syndrome 36.55 13.49 41 53673 96994 42470627
Suicidal ideation 36.51 13.49 8 53706 48153 42519468
Spinal compression fracture 36.34 13.49 46 53668 7437 42560184
Osteosclerosis 36.31 13.49 23 53691 1481 42566140
Chest pain 36.18 13.49 76 53638 139454 42428167
Gingivitis 36.14 13.49 34 53680 3939 42563682
Bone loss 35.58 13.49 17 53697 625 42566996
Jaw fracture 35.04 13.49 20 53694 1064 42566557
Periodontitis 34.86 13.49 26 53688 2185 42565436
Incorrect route of product administration 34.48 13.49 87 53627 24218 42543403
Wheezing 34.36 13.49 13 53701 54768 42512853
Hyperparathyroidism 34.22 13.49 21 53693 1278 42566343
Febrile neutropenia 33.33 13.49 121 53593 185582 42382039
Carcinoid tumour of the small bowel 32.74 13.49 14 53700 395 42567226
Prostate cancer recurrent 32.40 13.49 19 53695 1064 42566557
Septic shock 32.11 13.49 41 53673 91631 42475990
Blood parathyroid hormone decreased 32.07 13.49 22 53692 1621 42566000
Nephrocalcinosis 31.98 13.49 17 53697 786 42566835
Cardio-respiratory arrest 31.95 13.49 17 53697 58619 42509002
Bone fissure 31.75 13.49 10 53704 114 42567507
Somnolence 30.91 13.49 84 53630 141021 42426600
Gingival disorder 30.54 13.49 21 53693 1553 42566068
Metastases to peritoneum 30.39 13.49 25 53689 2424 42565197
Failure to anastomose 29.72 13.49 11 53703 210 42567411
Psoriasis 29.72 13.49 12 53702 48592 42519029
Sequestrectomy 29.62 13.49 11 53703 212 42567409
Anxiety 29.55 13.49 66 53648 118494 42449127
Erysipelas 29.46 13.49 38 53676 6258 42561363
Disease progression 29.22 13.49 293 53421 143363 42424258
Dental fistula 29.03 13.49 9 53705 97 42567524
Blood 1,25-dihydroxycholecalciferol increased 28.92 13.49 7 53707 26 42567595
Abdominal pain 28.62 13.49 133 53581 190338 42377283
Aggression 28.51 13.49 10 53704 44153 42523468
Hyperaesthesia 27.97 13.49 36 53678 5916 42561705
Cellulitis 27.83 13.49 152 53562 61433 42506188
Sedation 27.77 13.49 3 53711 30472 42537149
Carbohydrate antigen 15-3 increased 27.29 13.49 8 53706 70 42567551
Prostatic specific antigen abnormal 27.09 13.49 16 53698 908 42566713
Compression fracture 26.60 13.49 28 53686 3714 42563907
Treatment failure 26.38 13.49 24 53690 62600 42505021
International normalised ratio increased 26.19 13.49 14 53700 48154 42519467
Respiratory failure 26.06 13.49 79 53635 128053 42439568
Bone formation increased 26.04 13.49 5 53709 3 42567618
Spinal pain 25.77 13.49 37 53677 6745 42560876
Ulna fracture 25.77 13.49 12 53702 416 42567205
Pleurocutaneous fistula 25.01 13.49 7 53707 51 42567570
Lumbar vertebral fracture 24.79 13.49 25 53689 3154 42564467
Confusional state 24.60 13.49 118 53596 167479 42400142
Gingival abscess 24.02 13.49 9 53705 178 42567443
Osteonecrosis of external auditory canal 24.01 13.49 7 53707 60 42567561
Lymphocele 23.96 13.49 18 53696 1529 42566092
Neoplasm malignant 23.93 13.49 73 53641 22670 42544951
Eosinophilia 23.88 13.49 6 53708 32893 42534728
Stress 23.82 13.49 13 53701 44199 42523422
Pruritus 23.76 13.49 140 53574 188631 42378990
Hereditary optic atrophy 23.71 13.49 7 53707 63 42567558
Leukopenia 23.45 13.49 168 53546 74578 42493043
Hospice care 23.38 13.49 40 53674 8473 42559148
Coronary artery disease 23.34 13.49 20 53694 53700 42513921
Cardiogenic shock 23.13 13.49 8 53706 35632 42531989
Weight increased 23.11 13.49 65 53649 107918 42459703
Cough 23.00 13.49 131 53583 177972 42389649
Metabolic acidosis 22.90 13.49 19 53695 51839 42515782
Pyrexia 22.63 13.49 355 53359 393687 42173934
Oxygen saturation decreased 22.57 13.49 29 53685 64658 42502963
Extrapyramidal disorder 22.50 13.49 58 53656 16354 42551267
Tooth infection 22.47 13.49 38 53676 7973 42559648
Pseudarthrosis 22.29 13.49 7 53707 79 42567542
Autoimmune disorder 22.08 13.49 21 53693 2466 42565155
Metastases to soft tissue 21.98 13.49 11 53703 448 42567173
Hallucination, auditory 21.92 13.49 54 53660 14810 42552811
Mastication disorder 21.77 13.49 18 53696 1758 42565863
Transfusion-related circulatory overload 21.72 13.49 13 53701 756 42566865
Depression 21.70 13.49 70 53644 111293 42456328
Intentional product use issue 21.36 13.49 36 53678 71797 42495824
Cytokine release syndrome 21.34 13.49 15 53699 44512 42523109
Obstructive airways disorder 21.19 13.49 3 53711 24756 42542865
Lymphocyte count decreased 21.09 13.49 80 53634 27729 42539892
Gingival swelling 21.04 13.49 16 53698 1384 42566237
Macroenzyme creatine kinase 21.00 13.49 5 53709 17 42567604
Tremor 20.99 13.49 58 53656 96871 42470750
Blood calcium increased 20.98 13.49 38 53676 8416 42559205
Acute respiratory distress syndrome 20.89 13.49 6 53708 30102 42537519
Accidental overdose 20.88 13.49 5 53709 28325 42539296
Abnormal behaviour 20.86 13.49 4 53710 26447 42541174
Hypoglycaemia 20.71 13.49 27 53687 59827 42507794
Chest discomfort 20.71 13.49 30 53684 63586 42504035
Product use issue 20.56 13.49 41 53673 76710 42490911
Blood urea increased 20.20 13.49 8 53706 32785 42534836
Respiratory distress 20.16 13.49 14 53700 41806 42525815
Headache 19.98 13.49 199 53515 239170 42328451
Hypersensitivity 19.96 13.49 38 53676 72332 42495289
Loss of personal independence in daily activities 19.92 13.49 20 53694 49796 42517825
Allodynia 19.83 13.49 14 53700 1080 42566541
Arthralgia 19.82 13.49 366 53348 204872 42362749
Dental restoration failure 19.80 13.49 5 53709 23 42567598
Extraskeletal ossification 19.76 13.49 6 53708 60 42567561
Haematochezia 19.57 13.49 27 53687 58409 42509212
Bone fistula 19.46 13.49 5 53709 25 42567596
Neutrophil count increased 19.39 13.49 62 53652 19742 42547879
Dental operation 19.18 13.49 10 53704 444 42567177
Spinal cord compression 19.00 13.49 25 53689 4199 42563422
Palliative care 18.94 13.49 14 53700 1160 42566461
Therapeutic product effect incomplete 18.92 13.49 38 53676 70901 42496720
Injury associated with device 18.90 13.49 15 53699 1382 42566239
Hallucination 18.83 13.49 27 53687 57480 42510141
Splenic artery aneurysm 18.70 13.49 5 53709 30 42567591
Pericoronitis 18.67 13.49 4 53710 7 42567614
Asthenia 18.54 13.49 474 53240 280319 42287302
Anaphylactic reaction 18.46 13.49 16 53698 42727 42524894
Serotonin syndrome 18.21 13.49 5 53709 25840 42541781
Cytomegalovirus infection 18.14 13.49 9 53705 32297 42535324
Shock 18.11 13.49 7 53707 29114 42538507
Abscess oral 18.09 13.49 10 53704 500 42567121
Periodontal disease 17.99 13.49 12 53702 844 42566777
Overdose 17.95 13.49 70 53644 105194 42462427
Calculus urinary 17.86 13.49 16 53698 1741 42565880
Sepsis 17.78 13.49 163 53551 199171 42368450
Neurotoxicity 17.78 13.49 4 53710 23647 42543974
C-telopeptide increased 17.71 13.49 4 53710 10 42567611
Vitamin D increased 17.48 13.49 6 53708 91 42567530
Respiratory arrest 17.40 13.49 7 53707 28417 42539204
Lymphoedema 17.36 13.49 26 53688 4922 42562699
Psoriatic arthropathy 17.27 13.49 5 53709 24962 42542659
Unresponsive to stimuli 17.26 13.49 9 53705 31394 42536227
Hyperparathyroidism secondary 17.21 13.49 16 53698 1826 42565795
Vitamin D deficiency 17.20 13.49 34 53680 8039 42559582
Metastases to skin 17.09 13.49 10 53704 558 42567063
Pulpless tooth 17.03 13.49 3 53711 0 42567621
Calcium ionised abnormal 17.03 13.49 3 53711 0 42567621
Platelet count decreased 16.99 13.49 257 53457 138324 42429297
Generalised tonic-clonic seizure 16.98 13.49 6 53708 26373 42541248
Hallucination, visual 16.96 13.49 3 53711 21017 42546604
Limbic encephalitis 16.79 13.49 9 53705 423 42567198
Hypoxia 16.46 13.49 40 53674 69746 42497875
Prostatic specific antigen decreased 16.45 13.49 7 53707 195 42567426
Orthostatic hypotension 16.45 13.49 9 53705 30561 42537060
Metastases to eye 16.43 13.49 6 53708 110 42567511
Vipoma 16.29 13.49 4 53710 16 42567605
Abdominal distension 16.23 13.49 42 53672 71693 42495928
Medication error 16.11 13.49 11 53703 33143 42534478
Immunoglobulins decreased 16.10 13.49 12 53702 1007 42566614
Dyspnoea 16.07 13.49 430 53284 442191 42125430
Periprosthetic fracture 15.94 13.49 7 53707 211 42567410
Bile acid malabsorption 15.81 13.49 6 53708 123 42567498
Pulmonary hypertension 15.80 13.49 5 53709 23564 42544057
Acute myocardial infarction 15.64 13.49 31 53683 58134 42509487
Rebound effect 15.63 13.49 31 53683 7348 42560273
Drug reaction with eosinophilia and systemic symptoms 15.59 13.49 18 53696 42057 42525564
Myocardial infarction 15.57 13.49 92 53622 123917 42443704
Heart rate increased 15.55 13.49 27 53687 53228 42514393
Paraesthesia 15.48 13.49 151 53563 73308 42494313
Tibia fracture 15.41 13.49 15 53699 1813 42565808
Depressed level of consciousness 15.24 13.49 23 53691 47947 42519674
No adverse event 15.22 13.49 16 53698 39005 42528616
Oral cavity fistula 15.09 13.49 6 53708 140 42567481
Heart valve calcification 14.96 13.49 3 53711 3 42567618
Osteoporosis 14.90 13.49 47 53667 14859 42552762
Traumatic fracture 14.66 13.49 8 53706 390 42567231
Poor peripheral circulation 14.63 13.49 14 53700 1657 42565964
Respiratory depression 14.57 13.49 3 53711 18865 42548756
Appendicitis 14.50 13.49 4 53710 20609 42547012
Bedridden 14.38 13.49 22 53692 4243 42563378
Hepatic cytolysis 14.30 13.49 8 53706 26836 42540785
Postrenal failure 14.29 13.49 9 53705 574 42567047
Disease recurrence 14.22 13.49 10 53704 29668 42537953
Toxic epidermal necrolysis 14.21 13.49 8 53706 26742 42540879
Renal tubular necrosis 14.01 13.49 3 53711 18351 42549270
Nightmare 13.99 13.49 7 53707 25005 42542616
Blood glucose increased 13.89 13.49 47 53667 73652 42493969
Venous thrombosis limb 13.85 13.49 16 53698 2353 42565268
Lower respiratory tract infection 13.84 13.49 19 53695 41187 42526434
Hydrocalyx 13.75 13.49 3 53711 6 42567615
Alanine aminotransferase increased 13.69 13.49 61 53653 88345 42479276
Multiple fractures 13.61 13.49 13 53701 1535 42566086

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 21165.20 10.66 20993 230992 1479192 108858122
Osteonecrosis of jaw 16802.18 10.66 5649 246336 42368 110294946
Death 6662.55 10.66 8045 243940 690824 109646490
Hypocalcaemia 3376.54 10.66 2010 249975 63356 110273958
Bone pain 2057.25 10.66 1472 250513 63661 110273653
Spinal fracture 1926.62 10.66 969 251016 21664 110315650
Tooth disorder 1918.65 10.66 1055 250930 28454 110308860
Atypical femur fracture 1714.95 10.66 614 251371 5605 110331709
Pain in jaw 1518.75 10.66 1114 250871 50063 110287251
Tooth extraction 1481.76 10.66 680 251305 12311 110325003
Back pain 1430.53 10.66 2820 249165 368176 109969138
Metastases to bone 1170.93 10.66 786 251199 30586 110306728
Pain in extremity 1004.44 10.66 2903 249082 484215 109853099
Thoracic vertebral fracture 990.45 10.66 420 251565 6235 110331079
Bone density abnormal 933.54 10.66 347 251638 3556 110333758
Drug ineffective 919.66 10.66 1280 250705 1519260 108818054
Myalgia 841.91 10.66 1679 250306 220702 110116612
Lumbar vertebral fracture 812.47 10.66 403 251582 8728 110328586
Tooth fracture 807.09 10.66 453 251532 12714 110324600
Arthralgia 780.90 10.66 3676 248309 775956 109561358
Toothache 721.42 10.66 523 251462 23052 110314262
Exposed bone in jaw 711.81 10.66 283 251702 3528 110333786
Femur fracture 710.83 10.66 677 251308 43792 110293522
Pathological fracture 689.12 10.66 396 251589 11636 110325678
Toxicity to various agents 675.05 10.66 137 251848 480418 109856896
Bone density decreased 671.76 10.66 432 251553 15610 110321704
Terminal state 650.46 10.66 298 251687 5369 110331945
Spinal compression fracture 639.15 10.66 441 251544 17951 110319363
Blood parathyroid hormone increased 621.89 10.66 265 251720 3983 110333331
Jaw disorder 554.40 10.66 260 251725 4952 110332362
Osteomyelitis 550.65 10.66 539 251446 36061 110301253
Rebound effect 531 10.66 362 251623 14444 110322870
Completed suicide 506.82 10.66 9 251976 242372 110094942
Metastases to liver 489.70 10.66 498 251487 34888 110302426
Condition aggravated 485.07 10.66 577 251408 734259 109603055
Maternal exposure during pregnancy 477.75 10.66 25 251960 254858 110082456
Infusion related reaction 474.04 10.66 140 251845 381022 109956292
Tooth loss 470.44 10.66 269 251716 7827 110329487
Hip fracture 468.88 10.66 485 251500 34666 110302648
Neoplasm progression 467.59 10.66 653 251332 63942 110273372
Investigation 462.98 10.66 181 251804 2151 110335163
Breast cancer metastatic 455.59 10.66 296 251689 10885 110326429
Malignant neoplasm progression 453.93 10.66 1135 250850 173432 110163882
Synovitis 451.48 10.66 49 251936 274043 110063271
Pemphigus 440.47 10.66 10 251975 214560 110122754
Loose tooth 437.07 10.66 191 251794 3062 110334252
Groin pain 435.38 10.66 326 251659 15102 110322212
Blood calcium decreased 417.06 10.66 460 251525 35385 110301929
Drug intolerance 401.20 10.66 213 251772 406299 109931015
Dental implantation 398.92 10.66 121 251864 612 110336702
Product use in unapproved indication 390.46 10.66 271 251714 447106 109890208
Anti-cyclic citrullinated peptide antibody positive 387.91 10.66 5 251980 181979 110155335
Treatment failure 386.99 10.66 80 251905 277154 110060160
Bone loss 386.65 10.66 172 251813 2883 110334431
Drug abuse 377.60 10.66 5 251980 177406 110159908
Systemic lupus erythematosus 377.25 10.66 63 251922 254275 110083039
Fracture 376.50 10.66 367 251618 24421 110312893
Drug interaction 375.37 10.66 352 251633 499831 109837483
Contraindicated product administered 362.73 10.66 64 251921 248203 110089111
Helicobacter infection 360.24 10.66 12 251973 181865 110155449
Duodenal ulcer perforation 358.20 10.66 10 251975 177690 110159624
Dental caries 356.21 10.66 268 251717 12505 110324809
Bone disorder 350.76 10.66 329 251656 20863 110316451
Hospitalisation 348.06 10.66 905 251080 141588 110195726
Exposure during pregnancy 346.78 10.66 7 251978 167417 110169897
Pericarditis 341.61 10.66 47 251938 219067 110118247
Dental care 336.35 10.66 117 251868 972 110336342
Drug hypersensitivity 327.41 10.66 331 251654 453759 109883555
Acute kidney injury 326.09 10.66 594 251391 634836 109702478
Folliculitis 318.72 10.66 15 251970 167638 110169676
Hand deformity 309.19 10.66 61 251924 218445 110118869
Product storage error 308.32 10.66 310 251675 21418 110315896
Exostosis of jaw 307.12 10.66 113 251872 1122 110336192
Prostatic specific antigen increased 306.33 10.66 243 251742 12268 110325046
Hepatic enzyme increased 303.71 10.66 177 251808 320715 110016599
Confusional state 296.21 10.66 380 251605 468300 109869014
Foot fracture 295.73 10.66 327 251658 25219 110312095
Metastases to lung 292.87 10.66 310 251675 22753 110314561
Hypercalcaemia 291.51 10.66 440 251545 46217 110291097
Psoriatic arthropathy 291.18 10.66 49 251936 196712 110140602
Glossodynia 289.98 10.66 74 251911 221930 110115384
Therapeutic product effect decreased 287.14 10.66 99 251886 244217 110093097
Metastases to lymph nodes 285.26 10.66 252 251733 14780 110322534
Intentional overdose 285.26 10.66 3 251982 132498 110204816
Accidental exposure to product 283.63 10.66 451 251534 49557 110287757
Wheezing 280.60 10.66 115 251870 255115 110082199
Osteonecrosis 279.03 10.66 364 251621 33377 110303937
Muscle injury 276.35 10.66 10 251975 140797 110196517
Rheumatoid factor positive 274.65 10.66 5 251980 131635 110205679
Product use issue 272.88 10.66 188 251797 311507 110025807
Wound 270.37 10.66 98 251887 234339 110102975
Compression fracture 270.23 10.66 200 251785 9099 110328215
Hypotension 264.79 10.66 494 251491 523355 109813959
Hypophosphataemia 263.63 10.66 351 251634 32831 110304483
Osteonecrosis of external auditory canal 255.65 10.66 68 251917 190 110337124
Jaw operation 254.23 10.66 89 251896 755 110336559
Endodontic procedure 251.41 10.66 129 251856 3007 110334307
Fall 251.16 10.66 2283 249702 601199 109736115
C-reactive protein abnormal 248.48 10.66 11 251974 129684 110207630
Type 2 diabetes mellitus 247.55 10.66 51 251934 177181 110160133
Atypical fracture 245.99 10.66 92 251893 960 110336354
Osteitis 244.95 10.66 141 251844 4155 110333159
Liver injury 239.85 10.66 30 251955 150383 110186931
Periodontitis 227.34 10.66 144 251841 5064 110332250
Stress fracture 222.71 10.66 161 251824 7060 110330254
Tooth abscess 220.06 10.66 242 251743 18547 110318767
Breast cancer 217.74 10.66 347 251638 38195 110299119
Joint swelling 214.65 10.66 428 251557 442417 109894897
Overdose 214.09 10.66 134 251851 233660 110103654
Abscess jaw 213.25 10.66 97 251888 1717 110335597
Pelvic fracture 204.60 10.66 204 251781 13950 110323364
Irritable bowel syndrome 202.73 10.66 61 251924 164154 110173160
Metastases to central nervous system 200.99 10.66 254 251731 22563 110314751
Spinal pain 200.63 10.66 229 251756 18286 110319028
Blood calcium increased 200.37 10.66 226 251759 17814 110319500
Intentional product use issue 198.37 10.66 164 251821 247742 110089572
Wrist fracture 197.80 10.66 202 251783 14215 110323099
Facet joint syndrome 196.79 10.66 5 251980 96823 110240491
Gingivitis 193.66 10.66 172 251813 10159 110327155
Cardiac arrest 192.60 10.66 104 251881 196649 110140665
Injury 189.78 10.66 83 251902 177182 110160132
Gingival disorder 189.24 10.66 118 251867 4035 110333279
Intercepted product administration error 188.48 10.66 72 251913 800 110336514
Suicide attempt 187.96 10.66 12 251973 103382 110233932
Multiple fractures 181.99 10.66 156 251829 8784 110328530
Temporomandibular joint syndrome 181.54 10.66 112 251873 3757 110333557
Lower respiratory tract infection 179.89 10.66 173 251812 242933 110094381
Carbohydrate antigen 15-3 increased 177.58 10.66 82 251903 1505 110335809
Lip dry 169.62 10.66 16 251969 100067 110237247
Bradycardia 169.37 10.66 71 251914 155446 110181868
Rib fracture 165.20 10.66 285 251700 33485 110303829
Breast cancer stage III 165.05 10.66 3 251982 79114 110258200
Tooth infection 164.32 10.66 227 251758 21989 110315325
Swollen joint count increased 163.94 10.66 6 251979 83655 110253659
Cystitis 163.81 10.66 422 251563 65614 110271700
Blood calcium abnormal 163.09 10.66 80 251905 1689 110335625
Tetany 160.69 10.66 101 251884 3503 110333811
Sequestrectomy 159.33 10.66 63 251922 773 110336541
Tachycardia 158.89 10.66 169 251816 226476 110110838
Somnolence 158.67 10.66 271 251714 297178 110040136
Obesity 157.48 10.66 33 251952 113318 110223996
Weight increased 157.17 10.66 464 251521 419180 109918134
Febrile neutropenia 151.82 10.66 308 251677 316459 110020855
Coma 150.61 10.66 41 251944 117828 110219486
Gingival swelling 148.98 10.66 112 251873 5218 110332096
Swelling 147.32 10.66 367 251618 350674 109986640
Hypersensitivity 145.35 10.66 455 251530 403543 109933771
Tumour marker increased 145.17 10.66 108 251877 4952 110332362
Abdominal discomfort 144.95 10.66 439 251546 393419 109943895
Gingival recession 142.78 10.66 70 251915 1476 110335838
Metastases to spine 142.12 10.66 109 251876 5234 110332080
Occupational exposure to product 141.84 10.66 58 251927 781 110336533
Artificial crown procedure 140.29 10.66 45 251940 282 110337032
Hyperaesthesia teeth 139.88 10.66 79 251906 2243 110335071
Pyrexia 135.92 10.66 1350 250635 896915 109440399
Fibromyalgia 135.53 10.66 114 251871 170795 110166519
Musculoskeletal discomfort 133.06 10.66 212 251773 23326 110313988
Musculoskeletal pain 132.66 10.66 791 251194 182232 110155082
Prescribed overdose 131.34 10.66 21 251964 87560 110249754
Blister 128.88 10.66 199 251786 227177 110110137
Dental restoration failure 127.51 10.66 59 251926 1088 110336226
Gingival pain 127.36 10.66 168 251817 15568 110321746
Asthma 127.18 10.66 235 251750 250056 110087258
Vomiting 126.23 10.66 1397 250588 909278 109428036
Oedema 125.62 10.66 177 251808 209799 110127515
Upper limb fracture 123.43 10.66 192 251793 20696 110316618
Lactic acidosis 122.95 10.66 30 251955 92781 110244533
Depressed level of consciousness 122.67 10.66 51 251934 112227 110225087
Femoral neck fracture 122.13 10.66 147 251838 12420 110324894
Deep vein thrombosis postoperative 120.71 10.66 3 251982 59288 110278026
Vitamin D decreased 120.54 10.66 144 251841 12071 110325243
Dental operation 119.03 10.66 61 251924 1418 110335896
Cardio-respiratory arrest 118.14 10.66 58 251927 115778 110221536
Multiple organ dysfunction syndrome 118.09 10.66 103 251882 151607 110185707
Suicidal ideation 117.55 10.66 34 251951 93903 110243411
Hot flush 117.10 10.66 374 251611 65662 110271652
Prostate cancer metastatic 116.72 10.66 94 251891 4849 110332465
Hyperparathyroidism 115.34 10.66 84 251901 3726 110333588
Agitation 113.20 10.66 58 251927 112993 110224321
Muscle spasms 112.18 10.66 1046 250939 277111 110060203
Mastication disorder 111.67 10.66 80 251905 3458 110333856
Neutropenia 111.65 10.66 1325 250660 373295 109964019
Incorrect route of product administration 111.04 10.66 360 251625 63701 110273613
Dyspnoea 110.95 10.66 1815 250170 1105057 109232257
Bone lesion 107.74 10.66 105 251880 6982 110330332
Abdominal pain 107.35 10.66 706 251279 512283 109825031
Serotonin syndrome 107.11 10.66 7 251978 59146 110278168
Bedridden 106.61 10.66 142 251843 13283 110324031
Neoplasm malignant 106.56 10.66 251 251734 36892 110300422
Metabolic acidosis 106.27 10.66 47 251938 99697 110237617
White blood cell count decreased 106.12 10.66 889 251096 228501 110108813
Peripheral venous disease 106.08 10.66 30 251955 84087 110253227
Parathyroid tumour malignant 105.24 10.66 31 251954 139 110337175
Oral pain 103.07 10.66 249 251736 37195 110300119
Sleep disorder due to general medical condition, insomnia type 101.67 10.66 57 251928 105586 110231728
Unresponsive to stimuli 101 10.66 13 251972 63777 110273537
Fractured sacrum 100.80 10.66 61 251924 1975 110335339
Blepharospasm 97.83 10.66 7 251978 54844 110282470
Delirium 97.64 10.66 98 251887 134927 110202387
Influenza like illness 97.60 10.66 430 251555 87982 110249332
Gastrointestinal haemorrhage 97.53 10.66 141 251844 165377 110171937
Product quality issue 96.68 10.66 28 251957 77271 110260043
Humerus fracture 96.56 10.66 121 251864 10655 110326659
Jaw fistula 96.08 10.66 28 251957 120 110337194
Blood phosphorus decreased 95.49 10.66 102 251883 7563 110329751
International normalised ratio increased 95.46 10.66 39 251946 86733 110250581
Pulmonary fibrosis 95.44 10.66 57 251928 101985 110235329
Tibia fracture 93.50 10.66 94 251891 6491 110330823
Bone giant cell tumour malignant 91.56 10.66 18 251967 0 110337314
Rash pruritic 91.39 10.66 454 251531 97615 110239699
Rheumatoid arthritis 91.24 10.66 362 251623 299251 110038063
Body height decreased 90.52 10.66 116 251869 10447 110326867
Grip strength decreased 89.89 10.66 35 251950 80139 110257175
Dermatitis 89.72 10.66 197 251788 27640 110309674
Inflammation 88.25 10.66 193 251792 193045 110144269
Respiratory failure 88.05 10.66 228 251757 215104 110122210
Sinusitis 87.50 10.66 363 251622 296325 110040989
Discomfort 87.29 10.66 228 251757 214479 110122835
Eczema 87.04 10.66 361 251624 71932 110265382
Dental fistula 86.76 10.66 37 251948 557 110336757
Hypoglycaemia 86.57 10.66 82 251903 116022 110221292
Musculoskeletal chest pain 86.10 10.66 198 251787 28649 110308665
Hypercholesterolaemia 86.00 10.66 50 251935 90787 110246527
Hypoxia 85.89 10.66 101 251884 129414 110207900
Metastasis 85.79 10.66 100 251885 8167 110329147
Migraine 85.56 10.66 163 251822 171489 110165825
Arthropathy 85.28 10.66 351 251634 287171 110050143
Anaphylactic reaction 84.90 10.66 81 251904 114219 110223095
Osteoporotic fracture 84.77 10.66 81 251904 5256 110332058
Drug ineffective for unapproved indication 84.75 10.66 66 251919 102772 110234542
Wound infection 84.58 10.66 58 251927 96407 110240907
Hospice care 84.18 10.66 122 251863 12351 110324963
Lymphoedema 83.75 10.66 134 251851 14795 110322519
Pneumonia 83.34 10.66 1451 250534 875263 109462051
Urinary tract infection 82.28 10.66 1119 250866 325163 110012151
C-telopeptide increased 80.75 10.66 19 251966 25 110337289
Hungry bone syndrome 80.56 10.66 30 251955 309 110337005
Tooth erosion 80.11 10.66 32 251953 404 110336910
Dislocation of vertebra 79.68 10.66 5 251980 43716 110293598
Gingival abscess 79.37 10.66 42 251943 1045 110336269
Respiratory arrest 78.89 10.66 18 251967 58281 110279033
Red blood cell sedimentation rate increased 78.65 10.66 40 251945 78262 110259052
Infection 78.51 10.66 493 251492 361707 109975607
Product dose omission issue 78.06 10.66 1096 250889 320686 110016628
Lung disorder 78.01 10.66 185 251800 179862 110157452
Radius fracture 77.78 10.66 68 251917 3932 110333382
Joint range of motion decreased 76.59 10.66 99 251886 121733 110215581
Bursitis 76.21 10.66 111 251874 129807 110207507
Encephalopathy 76.19 10.66 45 251940 81010 110256304
Drug level increased 74.89 10.66 10 251975 47709 110289605
Parathyroid tumour benign 74.52 10.66 40 251945 1025 110336289
Jaw fracture 74.49 10.66 60 251925 3096 110334218
Eosinophilia 74.29 10.66 20 251965 57916 110279398
Cancer pain 73.78 10.66 84 251901 6688 110330626
X-ray abnormal 73.77 10.66 3 251982 38114 110299200
Delusion of grandeur 73.40 10.66 52 251933 2208 110335106
PIK3CA-activated mutation 72.90 10.66 34 251951 639 110336675
No adverse event 72.27 10.66 39 251946 73800 110263514
Cytokine release syndrome 71.99 10.66 35 251950 70271 110267043
Toxic epidermal necrolysis 71.96 10.66 20 251965 56707 110280607
Bone sequestrum 71.72 10.66 41 251944 1192 110336122
Ventricular fibrillation 71.63 10.66 6 251979 41307 110296007
Periodontal disease 71.46 10.66 49 251936 1973 110335341
Aggression 71.25 10.66 23 251962 59187 110278127
Colitis ulcerative 71.25 10.66 44 251941 77319 110259995
Musculoskeletal stiffness 70.83 10.66 362 251623 279460 110057854
Anxiety 70.07 10.66 479 251506 344599 109992715
Drug-induced liver injury 70.02 10.66 103 251882 119964 110217350
Adjustment disorder with depressed mood 69.34 10.66 9 251976 43874 110293440
Intentional self-injury 69.06 10.66 4 251981 37425 110299889
Osteosclerosis 68.84 10.66 67 251918 4448 110332866
Joint noise 68.63 10.66 71 251914 5072 110332242
Pulpitis dental 68.03 10.66 43 251942 1506 110335808
Dental necrosis 67.64 10.66 22 251963 145 110337169
Dental cleaning 67.51 10.66 15 251970 12 110337302
Oxygen saturation decreased 67.45 10.66 162 251823 156820 110180494
Prescribed underdose 67.41 10.66 32 251953 65142 110272172
Scoliosis 67.25 10.66 91 251894 8642 110328672
Psoriasis 67.11 10.66 136 251849 139857 110197457
Night sweats 66.96 10.66 127 251858 133856 110203458
Hyponatraemia 66.86 10.66 262 251723 217391 110119923
Road traffic accident 66.76 10.66 88 251897 107310 110230004
Haematochezia 66.50 10.66 100 251885 115424 110221890
Chest pain 66.17 10.66 544 251441 375831 109961483
Hyperparathyroidism secondary 65.92 10.66 57 251928 3247 110334067
Rhabdomyolysis 65.71 10.66 108 251877 120293 110217021
Gait disturbance 65.22 10.66 942 251043 277266 110060048
Multiple sclerosis relapse 65.07 10.66 17 251968 50223 110287091
Septic shock 65.00 10.66 166 251819 157362 110179952
Neuroleptic malignant syndrome 64.86 10.66 3 251982 34056 110303258
Therapy non-responder 64.73 10.66 166 251819 157141 110180173
Seizure 64.34 10.66 272 251713 220913 110116401
Cardiogenic shock 64.33 10.66 25 251960 57313 110280001
Medication error 63.81 10.66 88 251897 105278 110232036
Lymphocyte count abnormal 63.45 10.66 49 251936 2377 110334937
Therapeutic product effect incomplete 63.40 10.66 278 251707 223527 110113787
Muscle spasticity 62.87 10.66 5 251980 35910 110301404
Abortion spontaneous 62.24 10.66 4 251981 34278 110303036
Dysarthria 62.02 10.66 60 251925 84061 110253253
Hand fracture 61.58 10.66 84 251901 8038 110329276
Hallucination 61.14 10.66 85 251900 101347 110235967
C-reactive protein increased 60.94 10.66 272 251713 217647 110119667
Inappropriate schedule of product administration 60.92 10.66 721 251264 202916 110134398
Cytomegalovirus infection 60.65 10.66 24 251961 54420 110282894
Nasopharyngitis 60.56 10.66 590 251395 393771 109943543
Ulna fracture 60.51 10.66 37 251948 1221 110336093
Intentional product misuse 60.45 10.66 133 251852 132771 110204543
Liver disorder 60.16 10.66 148 251837 142095 110195219
Hyperkalaemia 60.05 10.66 138 251847 135658 110201656
Feeling abnormal 60.00 10.66 653 251332 180058 110157256
Hypophosphatasia 59.79 10.66 19 251966 115 110337199
Tooth resorption 59.56 10.66 15 251970 31 110337283
Injection site reaction 59.55 10.66 69 251916 89001 110248313
Vitamin D deficiency 59.46 10.66 131 251854 18421 110318893
Generalised tonic-clonic seizure 59.46 10.66 25 251960 54655 110282659
Dry skin 59.00 10.66 434 251551 107219 110230095
Denture wearer 58.71 10.66 18 251967 95 110337219
Peri-implantitis 58.41 10.66 21 251964 194 110337120
Oral cavity fistula 57.22 10.66 29 251956 658 110336656
Mouth swelling 57.19 10.66 77 251908 7277 110330037
Pain 57.18 10.66 2691 249294 952264 109385050
Cholesteatoma 55.99 10.66 20 251965 181 110337133
Osteoporosis 55.20 10.66 364 251621 86788 110250526
Device expulsion 54.93 10.66 4 251981 30887 110306427
Hormone-refractory prostate cancer 54.92 10.66 31 251954 879 110336435
Carcinoembryonic antigen increased 54.89 10.66 48 251937 2776 110334538
Parathyroid disorder 54.79 10.66 28 251957 647 110336667
Rectal haemorrhage 53.62 10.66 121 251864 119712 110217602
Drug reaction with eosinophilia and systemic symptoms 53.38 10.66 65 251920 82030 110255284
Cellulitis 53.34 10.66 479 251506 125537 110211777
Headache 53.13 10.66 1568 250417 880809 109456505
Accidental overdose 52.77 10.66 26 251959 51808 110285506
Hepatitis 52.76 10.66 77 251908 89977 110247337
Gastrointestinal disorder 52.56 10.66 329 251656 241623 110095691
Sedation 52.19 10.66 49 251936 69634 110267680
Obstructive airways disorder 51.97 10.66 20 251965 46129 110291185
Oral infection 51.61 10.66 68 251917 6293 110331021
Unevaluable event 51.54 10.66 269 251716 58958 110278356
Poisoning 51.09 10.66 4 251981 29101 110308213
Drug withdrawal syndrome 50.99 10.66 12 251973 38042 110299272
Bone erosion 50.74 10.66 21 251964 46350 110290964
Ill-defined disorder 50.64 10.66 185 251800 156668 110180646
Liver function test increased 50.62 10.66 77 251908 88471 110248843
Chest discomfort 50.42 10.66 214 251771 173634 110163680
Osteolysis 49.46 10.66 62 251923 5461 110331853
Polymyalgia rheumatica 49.41 10.66 67 251918 6375 110330939
Blood parathyroid hormone abnormal 49.17 10.66 22 251963 374 110336940
Spinal operation 49.02 10.66 89 251896 10883 110326431
Dental discomfort 48.95 10.66 24 251961 506 110336808
Mental status changes 48.73 10.66 61 251924 76061 110261253
C-reactive protein 48.46 10.66 6 251979 30325 110306989
Epilepsy 48.33 10.66 97 251888 100112 110237202
Intervertebral disc protrusion 48.30 10.66 156 251829 27542 110309772
Device failure 47.92 10.66 70 251915 7137 110330177
Menopausal symptoms 47.59 10.66 42 251943 2459 110334855
Parathyroid tumour 47.49 10.66 14 251971 63 110337251
Fatigue 47.48 10.66 3296 248689 1212662 109124652
Frequent bowel movements 46.97 10.66 56 251929 71334 110265980
Living in residential institution 46.76 10.66 29 251956 982 110336332
Premature delivery 46.71 10.66 7 251978 30625 110306689
Wrong technique in product usage process 46.64 10.66 350 251635 86998 110250316
Musculoskeletal disorder 46.38 10.66 135 251850 22529 110314785
Therapeutic response decreased 46.03 10.66 94 251891 96405 110240909
Spinal deformity 45.97 10.66 31 251954 1214 110336100
Autoimmune disorder 45.67 10.66 49 251936 65434 110271880
Neuropathy peripheral 45.61 10.66 616 251369 178661 110158653
Lupus-like syndrome 45.41 10.66 18 251967 40774 110296540
Acute respiratory distress syndrome 45.30 10.66 33 251952 53165 110284149
Disease progression 45.01 10.66 794 251191 243240 110094074
Onychomadesis 44.86 10.66 24 251961 45639 110291675
Oral discomfort 44.62 10.66 87 251898 11224 110326090
Metastases to skin 44.54 10.66 39 251946 2260 110335054
Tachypnoea 44.49 10.66 17 251968 39378 110297936
Depression 43.70 10.66 487 251498 316848 110020466
Nightmare 43.51 10.66 17 251968 38846 110298468
Agranulocytosis 43.31 10.66 46 251939 61714 110275600
Blood creatine phosphokinase increased 43.28 10.66 62 251923 73015 110264299
Tubulointerstitial nephritis 43.27 10.66 36 251949 54248 110283066
Respiratory depression 43.06 10.66 10 251975 31991 110305323
Bronchopulmonary aspergillosis 42.93 10.66 8 251977 29855 110307459
Sinus tachycardia 42.81 10.66 24 251961 44469 110292845
Kyphosis 42.53 10.66 44 251941 3143 110334171
Breast cancer recurrent 42.40 10.66 48 251937 3798 110333516
Noninfective gingivitis 42.39 10.66 36 251949 2001 110335313
Vitamin D abnormal 42.39 10.66 17 251968 217 110337097
Dementia 41.99 10.66 163 251822 31510 110305804
Parathyroidectomy 41.97 10.66 18 251967 275 110337039
Nerve compression 41.93 10.66 84 251901 11053 110326261
Dry mouth 41.83 10.66 275 251710 199673 110137641
Labelled drug-drug interaction medication error 41.80 10.66 8 251977 29294 110308020
Urticaria 41.70 10.66 495 251490 318362 110018952
Hypertension 41.63 10.66 866 251119 509218 109828096
Rhinalgia 41.56 10.66 48 251937 3881 110333433
Hypoaesthesia oral 41.48 10.66 108 251877 16894 110320420
Ankle fracture 41.47 10.66 119 251866 19700 110317614
Transplant rejection 41.43 10.66 4 251981 24563 110312751
Respiratory distress 41.22 10.66 58 251927 68816 110268498
Peripheral swelling 41.10 10.66 660 251325 403374 109933940
Disease recurrence 40.72 10.66 47 251938 60737 110276577
Mobility decreased 40.46 10.66 763 251222 236659 110100655
Alanine aminotransferase increased 40.37 10.66 249 251736 183524 110153790
Metastases to meninges 40.35 10.66 54 251931 5074 110332240
Circulatory collapse 40.22 10.66 24 251961 42969 110294345
Product label confusion 40.14 10.66 3 251982 22674 110314640
Renal tubular necrosis 40.07 10.66 10 251975 30465 110306849
Loss of consciousness 40.06 10.66 272 251713 196034 110141280
White blood cell count increased 39.98 10.66 102 251883 96740 110240574
Bone graft 39.88 10.66 24 251961 769 110336545
Blood 1,25-dihydroxycholecalciferol increased 39.80 10.66 13 251972 87 110337227
Product prescribing error 39.75 10.66 35 251950 51296 110286018
Onychomycosis 39.72 10.66 19 251966 38512 110298802
Acetabulum fracture 39.72 10.66 26 251959 968 110336346
Dental prosthesis placement 39.28 10.66 10 251975 22 110337292
Pleural neoplasm 39.00 10.66 19 251966 395 110336919
Acute myeloid leukaemia 38.97 10.66 19 251966 38091 110299223
Aspergillus infection 38.72 10.66 6 251979 25610 110311704
Dental prosthesis user 38.68 10.66 10 251975 24 110337290
Varicose vein 38.53 10.66 62 251923 6878 110330436
Coronary artery disease 38.47 10.66 65 251920 71625 110265689
Status epilepticus 38.45 10.66 12 251973 31559 110305755
Mastectomy 38.39 10.66 30 251955 1481 110335833
Drug tolerance decreased 38.28 10.66 8 251977 27532 110309782
Angioedema 38.20 10.66 107 251878 98393 110238921
Metastases to peritoneum 38.04 10.66 55 251930 5555 110331759
Erysipelas 37.83 10.66 89 251896 13069 110324245
Prostate cancer 37.75 10.66 178 251807 37463 110299851
Bone swelling 37.52 10.66 32 251953 1789 110335525
Shock 37.48 10.66 40 251945 53548 110283766
Pancytopenia 37.25 10.66 302 251683 209311 110128003
Pancreatitis 36.73 10.66 101 251884 93432 110243882
Onychoclasis 36.61 10.66 62 251923 7175 110330139
Breast disorder 36.52 10.66 35 251950 2279 110335035
Circumstance or information capable of leading to medication error 36.51 10.66 52 251933 5181 110332133
Ventricular tachycardia 36.48 10.66 36 251949 49973 110287341
Mydriasis 36.35 10.66 4 251981 22153 110315161
Stevens-Johnson syndrome 36.29 10.66 32 251953 46869 110290445
Abnormal behaviour 36.23 10.66 22 251963 39017 110298297
Fluid retention 36.17 10.66 103 251882 94204 110243110
Abdominal pain upper 35.93 10.66 569 251416 348542 109988772
Sleep disorder 35.85 10.66 285 251700 198359 110138955
Polyneuropathy in malignant disease 35.57 10.66 19 251966 482 110336832
Muscle tightness 35.22 10.66 93 251892 14669 110322645
Drug dose omission by device 35.20 10.66 92 251893 14424 110322890
Hemiparesis 35.14 10.66 29 251956 43874 110293440
Blood pressure decreased 35.04 10.66 139 251846 114952 110222362
Intercepted medication error 34.99 10.66 26 251959 1190 110336124
Torsade de pointes 34.84 10.66 5 251980 22595 110314719
Hepatic cirrhosis 34.76 10.66 63 251922 67563 110269751
Oral surgery 34.71 10.66 28 251957 1448 110335866
Orthostatic hypotension 34.70 10.66 61 251924 66188 110271126
Hyperparathyroidism primary 34.60 10.66 19 251966 510 110336804
Bone cancer 34.60 10.66 35 251950 2435 110334879
Paranoia 34.38 10.66 5 251980 22369 110314945
Activated partial thromboplastin time prolonged 34.36 10.66 5 251980 22363 110314951
Red blood cell sedimentation rate abnormal 34.31 10.66 7 251978 24502 110312812
Emotional distress 34.22 10.66 31 251954 44816 110292498
Hyperhidrosis 34.13 10.66 268 251717 187030 110150284
Sedation complication 34.10 10.66 3 251982 19852 110317462
Coagulopathy 34.03 10.66 26 251959 40885 110296429
Renal failure 33.90 10.66 341 251644 226233 110111081
Sepsis 33.86 10.66 533 251452 326813 110010501
Cataract operation 33.27 10.66 53 251932 5830 110331484
Right ventricular failure 33.20 10.66 9 251976 25945 110311369
Hepatic lesion 33.11 10.66 65 251920 8428 110328886
Blood alkaline phosphatase decreased 32.98 10.66 34 251951 2419 110334895
Tremor 32.96 10.66 298 251687 201934 110135380
Paraesthesia 32.88 10.66 844 251141 275677 110061637
Coeliac disease 32.78 10.66 30 251955 43157 110294157
Periprosthetic fracture 32.71 10.66 21 251964 756 110336558
Trismus 32.69 10.66 56 251929 6540 110330774
Staphylococcal infection 32.63 10.66 69 251916 69875 110267439
Abscess oral 32.59 10.66 28 251957 1581 110335733
Rheumatoid nodule 32.46 10.66 4 251981 20292 110317022
Tartrate-resistant acid phosphatase increased 32.45 10.66 7 251978 4 110337310
Gingival erythema 32.13 10.66 23 251962 993 110336321
Drug effective for unapproved indication 31.54 10.66 87 251898 14080 110323234
Syncope 31.48 10.66 302 251683 202234 110135080
Product substitution issue 31.44 10.66 7 251978 23054 110314260
Metaphyseal corner fracture 31.38 10.66 9 251976 36 110337278
Drug resistance 31.29 10.66 50 251935 56324 110280990
Bone resorption test abnormal 31.29 10.66 7 251978 6 110337308
Traumatic fracture 31.26 10.66 24 251961 1154 110336160
Diverticulitis 31.18 10.66 219 251766 53303 110284011
Haemoptysis 31.15 10.66 73 251912 71281 110266033
Dysgeusia 31.15 10.66 269 251716 69716 110267598
Limb discomfort 31.14 10.66 179 251806 40675 110296639
Haemodynamic instability 31.10 10.66 7 251978 22881 110314433
Lung neoplasm malignant 31.04 10.66 156 251829 33686 110303628
Bone cancer metastatic 31 10.66 15 251970 307 110337007
Ataxia 30.80 10.66 15 251970 30093 110307221
Forearm fracture 30.46 10.66 19 251966 650 110336664
Haematemesis 30.44 10.66 55 251930 59053 110278261
Calcinosis 30.43 10.66 35 251950 2817 110334497
Laryngitis 30.40 10.66 31 251954 42380 110294934
Parathyroid hormone-related protein increased 30.29 10.66 7 251978 8 110337306
Hypothermia 30.29 10.66 11 251974 26291 110311023
Dysstasia 30.22 10.66 152 251833 32834 110304480
Aspartate aminotransferase increased 30.01 10.66 227 251758 159709 110177605
Paronychia 29.76 10.66 73 251912 11008 110326306
Weight bearing difficulty 29.58 10.66 39 251946 3612 110333702
Infusion site reaction 29.50 10.66 3 251982 17679 110319635
Dyskinesia 29.15 10.66 45 251940 51401 110285913
Delusion 28.98 10.66 9 251976 23746 110313568
Tumour marker abnormal 28.91 10.66 14 251971 287 110337027
Immobile 28.89 10.66 58 251927 7644 110329670
Nail bed inflammation 28.86 10.66 29 251956 2001 110335313
Neck pain 28.85 10.66 417 251568 122713 110214601
Thyroid mass 28.83 10.66 46 251939 5067 110332247
General physical health deterioration 28.80 10.66 743 251242 424552 109912762
Bone fistula 28.75 10.66 10 251975 83 110337231
Cyanosis 28.68 10.66 16 251969 29725 110307589
Neoplasm 28.68 10.66 72 251913 11015 110326299
Cataract 28.61 10.66 292 251693 79193 110258121
Vitamin D increased 28.57 10.66 20 251965 833 110336481
Aphasia 28.54 10.66 57 251928 58940 110278374
Hypercalciuria 28.08 10.66 17 251968 551 110336763
Pulmonary arterial hypertension 27.99 10.66 20 251965 32548 110304766
Pelvic pain 27.99 10.66 90 251895 15852 110321462
Patella fracture 27.98 10.66 31 251954 2395 110334919
Hyperthermia 27.93 10.66 7 251978 21265 110316049
Irritability 27.88 10.66 41 251944 47768 110289546
Heart rate decreased 27.77 10.66 96 251889 82660 110254654
Gingival operation 27.74 10.66 11 251974 136 110337178
Ear pain 27.70 10.66 212 251773 53014 110284300
Palliative care 27.64 10.66 26 251959 1654 110335660
Abdominal lymphadenopathy 27.63 10.66 27 251958 1801 110335513
Acute myocardial infarction 27.57 10.66 98 251887 83679 110253635
Dizziness 27.54 10.66 1305 250680 696888 109640426
SARS-CoV-2 test positive 27.40 10.66 93 251892 16842 110320472
Rehabilitation therapy 27.35 10.66 29 251956 2132 110335182
Gingival injury 27.32 10.66 8 251977 35 110337279
Hip surgery 27.30 10.66 40 251945 4090 110333224
Immune system disorder 27.23 10.66 80 251905 13421 110323893
Metastases to bladder 27.18 10.66 14 251971 329 110336985
Bone marrow failure 27.04 10.66 57 251928 57791 110279523
Pollakiuria 27.03 10.66 183 251802 44012 110293302
Oral disorder 27.01 10.66 74 251911 11929 110325385
Rotator cuff syndrome 26.98 10.66 92 251893 16702 110320612
Nasal mucosal disorder 26.96 10.66 27 251958 1856 110335458
Suture rupture 26.92 10.66 18 251967 695 110336619
Vertebroplasty 26.84 10.66 14 251971 338 110336976
Pseudomonas infection 26.83 10.66 15 251970 27838 110309476
Bone formation increased 26.73 10.66 9 251976 67 110337247
Liver function test abnormal 26.66 10.66 75 251910 68875 110268439
Carbohydrate antigen 27.29 increased 26.60 10.66 10 251975 106 110337208
Rash papular 26.48 10.66 129 251856 27510 110309804
Respiratory rate increased 26.43 10.66 12 251973 25071 110312243
Streptococcal sepsis 26.38 10.66 44 251941 5028 110332286
Upper gastrointestinal haemorrhage 26.35 10.66 46 251939 50050 110287264
Back injury 26.34 10.66 42 251943 47357 110289957
Oedema peripheral 26.19 10.66 560 251425 328100 110009214
Acute respiratory failure 26.15 10.66 86 251899 75174 110262140
Pallor 26.09 10.66 56 251929 56411 110280903
Bone deformity 26.07 10.66 14 251971 359 110336955
Bronchiectasis 25.79 10.66 27 251958 36466 110300848
Amnesia 25.73 10.66 138 251847 105270 110232044
Neuroglycopenia 25.72 10.66 21 251964 1105 110336209
Diabetic ketoacidosis 25.59 10.66 35 251950 42023 110295291
Breath sounds abnormal 25.47 10.66 13 251972 25391 110311923
Lichen planus 25.45 10.66 35 251950 3375 110333939
Oral neoplasm benign 25.43 10.66 5 251980 0 110337314
Calcium ionised abnormal 25.43 10.66 5 251980 0 110337314
Scab 25.34 10.66 77 251908 13159 110324155
Hormone receptor positive HER2 negative breast cancer 25.33 10.66 12 251973 234 110337080
Pancreatitis acute 25.25 10.66 63 251922 60211 110277103
Coordination abnormal 25.16 10.66 13 251972 25215 110312099
Pulseless electrical activity 25.16 10.66 4 251981 16753 110320561
Post transplant lymphoproliferative disorder 25.16 10.66 3 251982 15610 110321704
Posterior reversible encephalopathy syndrome 25.13 10.66 24 251961 33837 110303477
Chronic sinusitis 24.91 10.66 13 251972 25071 110312243
Nephropathy toxic 24.79 10.66 16 251969 27462 110309852
Withdrawal syndrome 24.78 10.66 21 251964 31359 110305955
Photophobia 24.65 10.66 14 251971 25757 110311557
Hypervolaemia 24.60 10.66 47 251938 49413 110287901
Haematoma 24.59 10.66 61 251924 58415 110278899
Drug level decreased 24.55 10.66 6 251979 18542 110318772
Dysuria 24.49 10.66 227 251758 60004 110277310
Blood cholesterol increased 24.47 10.66 286 251699 184499 110152815
Hair disorder 24.41 10.66 21 251964 1188 110336126
Device dislocation 24.09 10.66 22 251963 31682 110305632
Carcinoid tumour of the small bowel 23.91 10.66 14 251971 426 110336888
Burning sensation 23.84 10.66 252 251733 68960 110268354
Myoclonus 23.79 10.66 24 251961 32974 110304340
Akathisia 23.73 10.66 5 251980 17108 110320206
Disorientation 23.70 10.66 82 251903 70589 110266725
Lumbar spinal stenosis 23.60 10.66 48 251937 6385 110330929
Incorrect dose administered 23.50 10.66 139 251846 103502 110233812
Acidosis 23.40 10.66 11 251974 22520 110314794
Thyroid operation 23.29 10.66 11 251974 213 110337101
Angina pectoris 23.18 10.66 69 251916 62226 110275088
Neutrophil count decreased 23.18 10.66 396 251589 120545 110216769
Epstein-Barr virus infection 23.04 10.66 7 251978 18731 110318583
Pulmonary hypertension 22.92 10.66 58 251927 55162 110282152
Rales 22.87 10.66 14 251971 24725 110312589
Adnexa uteri mass 22.68 10.66 14 251971 470 110336844
Drug tolerance 22.68 10.66 5 251980 16580 110320734
Hepatitis cholestatic 22.64 10.66 6 251979 17560 110319754
Gastroenteritis radiation 22.63 10.66 17 251968 791 110336523
Female genital tract fistula 22.55 10.66 5 251980 16514 110320800
Nephrocalcinosis 22.35 10.66 24 251961 1790 110335524
Oroantral fistula 22.31 10.66 13 251972 392 110336922
Peripheral circulatory failure 22.30 10.66 24 251961 1795 110335519
Vaccination site reaction 22.26 10.66 11 251974 236 110337078
Pulmonary alveolar haemorrhage 22.25 10.66 9 251976 20141 110317173
Cognitive disorder 22.24 10.66 113 251872 87398 110249916
Bone marrow oedema 22.24 10.66 26 251959 2130 110335184
Aplastic anaemia 22.14 10.66 14 251971 24294 110313020
Prostate cancer recurrent 22.09 10.66 18 251967 944 110336370
Altered state of consciousness 22.05 10.66 63 251922 57563 110279751
Papillary thyroid cancer 22.05 10.66 30 251955 2864 110334450
Progressive multifocal leukoencephalopathy 21.88 10.66 15 251970 24941 110312373
Taste disorder 21.84 10.66 76 251909 65311 110272003
Gingival ulceration 21.83 10.66 20 251965 1230 110336084
Rash macular 21.78 10.66 157 251828 38529 110298785
Blood pressure abnormal 21.73 10.66 105 251880 22319 110314995
Giant cell arteritis 21.51 10.66 34 251951 3715 110333599
Proctitis 21.41 10.66 6 251979 16921 110320393
Cervical vertebral fracture 21.40 10.66 38 251947 4567 110332747
Quality of life decreased 21.36 10.66 76 251909 14093 110323221
Osteomalacia 21.34 10.66 22 251963 1565 110335749
Spinal disorder 21.31 10.66 67 251918 11661 110325653
Metastases to bone marrow 21.26 10.66 18 251967 996 110336318
Vascular device infection 21.10 10.66 84 251901 16428 110320886
Pathogen resistance 21.02 10.66 7 251978 17665 110319649
Pustular psoriasis 21.00 10.66 3 251982 13602 110323712
Pleurocutaneous fistula 20.92 10.66 7 251978 51 110337263
Heart rate increased 20.88 10.66 218 251767 143616 110193698
Vertebral lesion 20.80 10.66 15 251970 655 110336659
Clavicle fracture 20.74 10.66 41 251944 5343 110331971
Blood 1,25-dihydroxycholecalciferol decreased 20.69 10.66 7 251978 53 110337261
Chemotherapy 20.68 10.66 25 251960 2121 110335193
Actinomycosis 20.64 10.66 20 251965 1320 110335994
Pneumonia aspiration 20.58 10.66 105 251880 81128 110256186
Metastatic neoplasm 20.58 10.66 43 251942 5830 110331484
Infusion site pain 20.55 10.66 7 251978 17412 110319902
Spinal cord compression 20.54 10.66 50 251935 7502 110329812
Angina unstable 20.46 10.66 6 251979 16426 110320888
Blood cholesterol decreased 20.46 10.66 28 251957 2688 110334626
Drug dependence 20.40 10.66 53 251932 49967 110287347
Blood 25-hydroxycholecalciferol decreased 20.37 10.66 13 251972 463 110336851
Blood magnesium decreased 20.37 10.66 95 251890 19901 110317413
Tooth discolouration 20.36 10.66 20 251965 1343 110335971
Leukopenia 20.35 10.66 463 251522 148328 110188986
Serum procollagen type I N-terminal propeptide decreased 20.35 10.66 4 251981 0 110337314
Root canal infection 20.30 10.66 13 251972 466 110336848
Pulmonary oedema 20.26 10.66 140 251845 100519 110236795
Hallucination, visual 20.26 10.66 37 251948 39568 110297746
Fibula fracture 20.16 10.66 37 251948 4561 110332753
Aspiration 20.03 10.66 24 251961 30509 110306805
Haemorrhage intracranial 19.84 10.66 22 251963 28947 110308367
Spondylolisthesis 19.83 10.66 33 251952 3765 110333549
Electrocardiogram QRS complex prolonged 19.80 10.66 3 251982 13018 110324296
Finger deformity 19.67 10.66 28 251957 33064 110304250
Monocytosis 19.67 10.66 22 251963 1718 110335596
Bone fissure 19.65 10.66 14 251971 600 110336714
Renal injury 19.64 10.66 9 251976 18704 110318610
Bacteraemia 19.62 10.66 42 251943 42348 110294966
Intramedullary rod insertion 19.61 10.66 10 251975 230 110337084
Sinus bradycardia 19.53 10.66 23 251962 29460 110307854
Failure to anastomose 19.53 10.66 10 251975 232 110337082
Fibroblast growth factor 23 increased 19.52 10.66 6 251979 32 110337282
Bone metabolism biochemical marker increased 19.52 10.66 6 251979 32 110337282
Affect lability 19.51 10.66 9 251976 18628 110318686
Vertigo 19.49 10.66 292 251693 86578 110250736
Device fastener issue 19.48 10.66 8 251977 109 110337205
Flushing 19.48 10.66 149 251836 104587 110232727
Xeroderma 19.46 10.66 14 251971 609 110336705
Personality disorder 19.42 10.66 3 251982 12834 110324480
Temperature regulation disorder 19.40 10.66 3 251982 12823 110324491
Neurotoxicity 19.38 10.66 42 251943 42165 110295149
Sarcoma 19.20 10.66 17 251968 1000 110336314
Hepatic cytolysis 19.06 10.66 63 251922 54990 110282324
Hypovolaemia 19.04 10.66 13 251972 21661 110315653
CYP3A4 polymorphism 18.98 10.66 7 251978 70 110337244
Degenerative bone disease 18.97 10.66 9 251976 176 110337138
Adjusted calcium decreased 18.96 10.66 10 251975 247 110337067
Sense of oppression 18.91 10.66 21 251964 1627 110335687
Bone scan abnormal 18.89 10.66 10 251975 249 110337065
Fistula 18.88 10.66 77 251908 15222 110322092
Gait inability 18.87 10.66 209 251776 136167 110201147
Extraskeletal ossification 18.85 10.66 8 251977 119 110337195
Blood uric acid increased 18.79 10.66 13 251972 21516 110315798
Vertebral wedging 18.79 10.66 6 251979 37 110337277
Disturbance in attention 18.79 10.66 75 251910 61920 110275394
Pulmonary haemorrhage 18.75 10.66 7 251978 16449 110320865
Nephrolithiasis 18.72 10.66 232 251753 65980 110271334
Nasal congestion 18.67 10.66 139 251846 98143 110239171
Substance abuse 18.66 10.66 3 251982 12460 110324854
Tumour pain 18.55 10.66 28 251957 2939 110334375
Hepatic cyst 18.54 10.66 49 251936 7734 110329580
Macroenzyme creatine kinase 18.54 10.66 5 251980 15 110337299
Skin discolouration 18.53 10.66 182 251803 48864 110288450
Oligodipsia 18.52 10.66 6 251979 39 110337275
Decreased immune responsiveness 18.50 10.66 56 251929 9550 110327764
Pneumocystis jirovecii pneumonia 18.43 10.66 44 251941 42691 110294623
Prostatic specific antigen abnormal 18.38 10.66 14 251971 665 110336649
Vaginal discharge 18.20 10.66 9 251976 17899 110319415
Pain of skin 18.14 10.66 92 251893 19937 110317377
White blood cell disorder 18.13 10.66 32 251953 3827 110333487
Myocardial infarction 18.13 10.66 318 251667 191765 110145549
Bone neoplasm 18.10 10.66 16 251969 939 110336375
Thrombotic microangiopathy 17.99 10.66 24 251961 29125 110308189
Medial tibial stress syndrome 17.97 10.66 9 251976 199 110337115
Contusion 17.90 10.66 400 251585 232961 110104353
Invasive lobular breast carcinoma 17.89 10.66 15 251970 819 110336495
Subarachnoid haemorrhage 17.78 10.66 25 251960 29677 110307637
Radiation fibrosis - lung 17.77 10.66 7 251978 85 110337229
Acute generalised exanthematous pustulosis 17.72 10.66 14 251971 21650 110315664
Hypomagnesaemia 17.70 10.66 213 251772 60157 110277157
Hereditary optic atrophy 17.70 10.66 7 251978 86 110337228
Rash maculo-papular 17.66 10.66 98 251887 74124 110263190
Cardiac failure congestive 17.64 10.66 240 251745 150760 110186554
Parathyroid gland operation 17.63 10.66 5 251980 19 110337295
Therapeutic response shortened 17.61 10.66 25 251960 29558 110307756
Nail disorder 17.61 10.66 70 251915 57865 110279449
Hypercalcaemic nephropathy 17.58 10.66 4 251981 4 110337310
Onychalgia 17.57 10.66 17 251968 1120 110336194
Bronchospasm 17.57 10.66 26 251959 30213 110307101
Haemophagocytic lymphohistiocytosis 17.50 10.66 28 251957 31531 110305783
VIth nerve paresis 17.47 10.66 8 251977 144 110337170
Sensory loss 17.39 10.66 14 251971 21443 110315871
Osteocalcin decreased 17.34 10.66 6 251979 49 110337265
Metastases to neck 17.34 10.66 6 251979 49 110337265
Exposure to toxic agent 17.33 10.66 4 251981 12854 110324460
Immune effector cell-associated neurotoxicity syndrome 17.33 10.66 6 251979 14776 110322538
Blood pressure increased 17.31 10.66 452 251533 257921 110079393
Atelectasis 17.30 10.66 36 251949 36676 110300638
Respiratory acidosis 17.30 10.66 5 251980 13821 110323493
Caesarean section 17.28 10.66 5 251980 13812 110323502
Pneumonia fungal 17.28 10.66 6 251979 14748 110322566
Anger 17.24 10.66 11 251974 18996 110318318
Anuria 17.21 10.66 18 251967 24323 110312991
Prostatic specific antigen decreased 17.20 10.66 7 251978 93 110337221
Anaphylactic shock 17.16 10.66 60 251925 51486 110285828
Immunosuppressant drug level increased 17.16 10.66 3 251982 11721 110325593
Breast pain 17.14 10.66 56 251929 9944 110327370
Hyperammonaemia 17.12 10.66 5 251980 13727 110323587
Respiratory disorder 17.12 10.66 94 251891 71288 110266026
Drug level below therapeutic 17.05 10.66 3 251982 11670 110325644
Invasive ductal breast carcinoma 17.02 10.66 43 251942 6603 110330711
Encephalitis 16.95 10.66 11 251974 18828 110318486
Carbohydrate antigen 15-3 16.81 10.66 7 251978 99 110337215
Ulcer haemorrhage 16.75 10.66 16 251969 22555 110314759
Creatinine renal clearance decreased 16.74 10.66 15 251970 21800 110315514
Triple negative breast cancer 16.72 10.66 12 251973 520 110336794
Nail avulsion 16.70 10.66 8 251977 160 110337154
Dental paraesthesia 16.69 10.66 4 251981 6 110337308
Pulpless tooth 16.69 10.66 4 251981 6 110337308
Metastases to pleura 16.66 10.66 22 251963 2041 110335273
Brain injury 16.63 10.66 5 251980 13471 110323843
Osteosarcoma 16.61 10.66 11 251974 418 110336896
Skin disorder 16.58 10.66 160 251825 42753 110294561
Toxic encephalopathy 16.47 10.66 7 251978 15207 110322107
Atrioventricular block complete 16.40 10.66 13 251972 20069 110317245
Oral mucosal erythema 16.38 10.66 23 251962 2261 110335053
Ovarian cancer 16.36 10.66 33 251952 4363 110332951
Atrophic vulvovaginitis 16.34 10.66 18 251967 1382 110335932
Catatonia 16.30 10.66 3 251982 11297 110326017
Gingival discolouration 16.24 10.66 9 251976 246 110337068
Oesophageal ulcer haemorrhage 16.18 10.66 15 251970 937 110336377
Diffuse large B-cell lymphoma 16.14 10.66 8 251977 15890 110321424
Hypercalcaemia of malignancy 16.13 10.66 12 251973 550 110336764
Dental alveolar anomaly 16.06 10.66 5 251980 28 110337286
Mucosal inflammation 16.03 10.66 308 251677 95833 110241481
Respiratory symptom 15.98 10.66 7 251978 14938 110322376
Stress 15.98 10.66 158 251827 105190 110232124
Troponin increased 15.96 10.66 27 251958 29739 110307575
Haematuria 15.95 10.66 117 251868 82888 110254426
Affective disorder 15.85 10.66 59 251926 11182 110326132
Enchondromatosis 15.81 10.66 7 251978 116 110337198
Eastern Cooperative Oncology Group performance status worsened 15.77 10.66 26 251959 2943 110334371
Ovarian disorder 15.61 10.66 12 251973 578 110336736
Upper respiratory tract infection 15.61 10.66 208 251777 131120 110206194
Panniculitis 15.58 10.66 8 251977 15574 110321740
Joint destruction 15.58 10.66 3 251982 10940 110326374
Metastases to soft tissue 15.57 10.66 13 251972 706 110336608
Venous thrombosis limb 15.56 10.66 36 251949 5229 110332085
Immunoglobulins decreased 15.52 10.66 23 251962 2376 110334938
Heavy menstrual bleeding 15.50 10.66 9 251976 16356 110320958
Cardiac murmur 15.49 10.66 20 251965 24608 110312706
Impaired quality of life 15.39 10.66 28 251957 29989 110307325
Haemorrhage 15.36 10.66 162 251823 106530 110230784
Acute coronary syndrome 15.34 10.66 18 251967 23094 110314220
Oliguria 15.34 10.66 12 251973 18645 110318669
Arthropod infestation 15.26 10.66 3 251982 0 110337314
Diabetic endorgan damage 15.26 10.66 3 251982 0 110337314
Periodontal operation 15.26 10.66 3 251982 0 110337314
Refusal of treatment by patient 15.24 10.66 52 251933 9442 110327872
Injection site erythema 15.24 10.66 139 251846 94037 110243277
Macule 15.19 10.66 29 251956 3684 110333630
Allergy to plants 15.17 10.66 14 251971 869 110336445
Ulcer 15.16 10.66 49 251936 43067 110294247
Respiratory syncytial virus infection 15.15 10.66 7 251978 14477 110322837
Skin necrosis 15.11 10.66 16 251969 21496 110315818
Myasthenia gravis 15.10 10.66 16 251969 21495 110315819
Ear disorder 15.08 10.66 34 251951 4855 110332459
Mouth ulceration 15.07 10.66 172 251813 47966 110289348
Surgery 15.02 10.66 152 251833 41131 110296183
Hypoacusis 15 10.66 134 251851 35057 110302257
Blood creatinine abnormal 14.96 10.66 38 251947 5854 110331460
Intervertebral disc degeneration 14.95 10.66 81 251904 18004 110319310
Sternal fracture 14.94 10.66 27 251958 3289 110334025
Basal cell carcinoma 14.86 10.66 53 251932 45217 110292097
Ear infection 14.83 10.66 83 251902 62649 110274665
Extradural neoplasm 14.83 10.66 4 251981 12 110337302
Device malfunction 14.82 10.66 22 251963 25536 110311778
Catheter site injury 14.77 10.66 9 251976 295 110337019
Gingival atrophy 14.73 10.66 6 251979 80 110337234
Tumour lysis syndrome 14.69 10.66 30 251955 30771 110306543
Dental cyst 14.65 10.66 5 251980 39 110337275
Blood glucose increased 14.62 10.66 213 251772 132283 110205031
Chronic leukaemia 14.59 10.66 4 251981 13 110337301
Bacterial sepsis 14.55 10.66 3 251982 10423 110326891
Myocardial ischaemia 14.50 10.66 24 251961 26660 110310654
Enterococcal infection 14.47 10.66 15 251970 20351 110316963
Metastases to the mediastinum 14.46 10.66 13 251972 780 110336534
Nasal polyps 14.41 10.66 6 251979 13194 110324120
Seronegative arthritis 14.36 10.66 6 251979 13171 110324143
Breast mass 14.33 10.66 46 251939 8095 110329219
Tooth deposit 14.27 10.66 9 251976 314 110337000
Hepatocellular injury 14.27 10.66 63 251922 50579 110286735
Paraesthesia oral 14.24 10.66 128 251857 33543 110303771
Deafness 14.24 10.66 107 251878 26602 110310712
Polyneuropathy 14.22 10.66 123 251862 31889 110305425
Ankylosing spondylitis 14.21 10.66 9 251976 15603 110321711
Appendicitis 14.20 10.66 27 251958 28437 110308877
Wrong product administered 14.20 10.66 56 251929 10904 110326410
Metastases to chest wall 14.18 10.66 12 251973 664 110336650
Dyspepsia 14.17 10.66 329 251656 190636 110146678
Melaena 14.15 10.66 95 251890 68662 110268652
Retinal operation 14.15 10.66 4 251981 15 110337299
Skin sensitisation 14.13 10.66 15 251970 1104 110336210
Carbohydrate antigen 19-9 increased 14.04 10.66 11 251974 545 110336769
Hypercapnia 14.03 10.66 4 251981 11155 110326159
Spinal laminectomy 13.98 10.66 13 251972 815 110336499
Carcinoembryonic antigen 13.97 10.66 6 251979 92 110337222
Pulmonary tumour thrombotic microangiopathy 13.97 10.66 7 251978 155 110337159
Hypoaesthesia teeth 13.93 10.66 5 251980 46 110337268
Malpositioned teeth 13.93 10.66 5 251980 46 110337268
COVID-19 pneumonia 13.92 10.66 41 251944 37102 110300212
Tuberculosis 13.90 10.66 12 251973 17762 110319552
Metastases to eye 13.90 10.66 9 251976 329 110336985
Jaundice cholestatic 13.88 10.66 8 251977 14600 110322714
Pelvi-ureteric obstruction 13.87 10.66 9 251976 330 110336984
Hepatomegaly 13.87 10.66 17 251968 21397 110315917
Food allergy 13.83 10.66 15 251970 19933 110317381
Haemodialysis 13.82 10.66 12 251973 17707 110319607
High turnover osteopathy 13.80 10.66 6 251979 95 110337219
Pleural effusion 13.79 10.66 515 251470 177194 110160120
Escherichia urinary tract infection 13.78 10.66 73 251912 16089 110321225
Metastases to vagina 13.75 10.66 4 251981 17 110337297
Adenosquamous cell lung cancer 13.74 10.66 5 251980 48 110337266
Osteoporosis postmenopausal 13.74 10.66 5 251980 48 110337266
Arteriosclerosis 13.71 10.66 22 251963 24745 110312569
Pericoronitis 13.69 10.66 7 251978 162 110337152
Presyncope 13.66 10.66 61 251924 48826 110288488
Gas gangrene 13.66 10.66 9 251976 339 110336975
Arthritis 13.57 10.66 488 251497 167098 110170216
Blood phosphorus abnormal 13.56 10.66 9 251976 343 110336971
Tardive dyskinesia 13.54 10.66 7 251978 13572 110323742
Tricuspid valve incompetence 13.41 10.66 21 251964 23852 110313462
Fracture nonunion 13.39 10.66 17 251968 1517 110335797
Psychotic disorder 13.39 10.66 65 251920 50872 110286442
Constipation 13.37 10.66 967 251018 356819 109980495
Adjustment disorder 13.33 10.66 4 251981 10791 110326523
Mucosal pain 13.30 10.66 5 251980 53 110337261
Sudden death 13.20 10.66 22 251963 24373 110312941
Nail discolouration 13.19 10.66 27 251958 3608 110333706
Skeletal dysplasia 13.19 10.66 3 251982 3 110337311
Follicular dendritic cell sarcoma 13.19 10.66 3 251982 3 110337311
Bone infarction 13.08 10.66 11 251974 603 110336711
BRCA2 gene mutation 13.00 10.66 6 251979 110 110337204
Bone fragmentation 12.98 10.66 12 251973 747 110336567
Inappropriate antidiuretic hormone secretion 12.96 10.66 37 251948 33814 110303500
Deafness neurosensory 12.95 10.66 3 251982 9616 110327698
Bladder disorder 12.92 10.66 55 251930 11082 110326232
Neurological symptom 12.88 10.66 10 251975 15598 110321716
Nail bed tenderness 12.85 10.66 9 251976 375 110336939
Urine calcium increased 12.85 10.66 6 251979 113 110337201
Forced expiratory volume decreased 12.83 10.66 7 251978 13169 110324145
Blood phosphorus increased 12.82 10.66 11 251974 16329 110320985
Eye inflammation 12.82 10.66 48 251937 9123 110328191
Transfusion-related circulatory overload 12.81 10.66 13 251972 908 110336406
Metastases to adrenals 12.80 10.66 17 251968 1586 110335728
Electrocardiogram QT interval 12.74 10.66 8 251977 277 110337037
Cementoplasty 12.73 10.66 3 251982 4 110337310
Otitis externa bacterial 12.73 10.66 3 251982 4 110337310
Gingival cyst 12.73 10.66 3 251982 4 110337310
Hypopnoea 12.70 10.66 5 251980 11375 110325939
Lip exfoliation 12.70 10.66 12 251973 768 110336546
Sputum discoloured 12.67 10.66 28 251957 27917 110309397
Demyelination 12.58 10.66 3 251982 9426 110327888
Naevus haemorrhage 12.57 10.66 6 251979 119 110337195
Atrial fibrillation 12.55 10.66 413 251572 229229 110108085
Colonoscopy 12.55 10.66 20 251965 2200 110335114
Wisdom teeth removal 12.46 10.66 12 251973 786 110336528
Osteopenia 12.43 10.66 90 251895 22119 110315195
Adrenal insufficiency 12.39 10.66 52 251933 42338 110294976
Open fracture 12.38 10.66 10 251975 518 110336796
Chondropathy 12.37 10.66 23 251962 2864 110334450
Eosinophil count increased 12.34 10.66 18 251967 21040 110316274
Bone giant cell tumour benign 12.33 10.66 3 251982 5 110337309
Phosphaturic mesenchymal tumour 12.33 10.66 3 251982 5 110337309
Myelodysplastic syndrome 12.23 10.66 44 251941 37440 110299874
Exposure to SARS-CoV-2 12.19 10.66 23 251962 2896 110334418
Staphylococcal bacteraemia 12.19 10.66 12 251973 16676 110320638
Treatment noncompliance 12.13 10.66 107 251878 72883 110264431
Hyperbilirubinaemia 12.13 10.66 33 251952 30638 110306676
Nail growth abnormal 12.10 10.66 10 251975 535 110336779
Methaemoglobinaemia 12.07 10.66 3 251982 9165 110328149
Thyroid disorder 12.06 10.66 73 251912 16896 110320418
Alopecia 12.00 10.66 976 251009 363777 109973537
Vascular fragility 11.99 10.66 7 251978 212 110337102
Hydrocalyx 11.98 10.66 3 251982 6 110337308
Hypocalcaemic seizure 11.97 10.66 6 251979 133 110337181
Periumbilical abscess 11.94 10.66 8 251977 310 110337004
Device loosening 11.92 10.66 12 251973 830 110336484
Injury associated with device 11.88 10.66 29 251956 4360 110332954
Sinus congestion 11.87 10.66 33 251952 30426 110306888
Malocclusion 11.87 10.66 7 251978 216 110337098
Asphyxia 11.87 10.66 9 251976 14206 110323108
Blood pressure fluctuation 11.86 10.66 111 251874 74713 110262601
Purulence 11.86 10.66 20 251965 2307 110335007
Deformity thorax 11.85 10.66 4 251981 30 110337284
Tachyphylaxis 11.85 10.66 9 251976 426 110336888
Productive cough 11.84 10.66 186 251799 114119 110223195
Spinal column injury 11.83 10.66 20 251965 2311 110335003
Mood altered 11.82 10.66 19 251966 21356 110315958
Laryngitis viral 11.80 10.66 5 251980 74 110337240
Metastases to pelvis 11.80 10.66 12 251973 840 110336474
Alcohol poisoning 11.78 10.66 3 251982 9017 110328297
Calcium deficiency 11.77 10.66 14 251971 1168 110336146
Bradyphrenia 11.76 10.66 6 251979 11722 110325592
Immunodeficiency 11.76 10.66 47 251938 38791 110298523
Autoimmune lung disease 11.75 10.66 7 251978 220 110337094
Knee operation 11.75 10.66 39 251946 6983 110330331
Metastases to pituitary gland 11.74 10.66 4 251981 31 110337283
Serum procollagen type I N-terminal propeptide increased 11.74 10.66 4 251981 31 110337283
Osteoradionecrosis 11.73 10.66 6 251979 139 110337175
Decreased appetite 11.70 10.66 1247 250738 474599 109862715
Blood culture positive 11.70 10.66 3 251982 8973 110328341
Hepatic necrosis 11.68 10.66 4 251981 9918 110327396
Gangrene 11.65 10.66 12 251973 16329 110320985
Lower gastrointestinal haemorrhage 11.64 10.66 15 251970 18471 110318843
Potentiating drug interaction 11.61 10.66 6 251979 11637 110325677
Respiratory tract congestion 11.61 10.66 34 251951 30823 110306491
Adjusted calcium increased 11.56 10.66 5 251980 78 110337236
Haemangioma 11.53 10.66 22 251963 2794 110334520
Avulsion fracture 11.52 10.66 8 251977 329 110336985
Blood glucose decreased 11.46 10.66 32 251953 29456 110307858
Eosinophilic granulomatosis with polyangiitis 11.43 10.66 5 251980 10681 110326633
Complication of device insertion 11.43 10.66 3 251982 8835 110328479
Bone metabolism disorder 11.41 10.66 10 251975 580 110336734
Euphoric mood 11.41 10.66 3 251982 8824 110328490
Catheter site bruise 11.40 10.66 10 251975 581 110336733
Metastases to uterus 11.34 10.66 5 251980 82 110337232
Fracture delayed union 11.32 10.66 19 251966 2182 110335132
Mandibular mass 11.31 10.66 7 251978 236 110337078
Gingival erosion 11.31 10.66 6 251979 150 110337164
Pleural disorder 11.31 10.66 13 251972 1046 110336268
Gastrointestinal bacterial infection 11.26 10.66 15 251970 1403 110335911
Atrial flutter 11.26 10.66 24 251961 24238 110313076
Hypovolaemic shock 11.22 10.66 10 251975 14573 110322741
Hypocalciuria 11.22 10.66 4 251981 36 110337278
Blood creatinine increased 11.20 10.66 324 251661 182565 110154749
Triple positive breast cancer 11.12 10.66 3 251982 9 110337305
Injected limb mobility decreased 11.12 10.66 4 251981 37 110337277
Nasopharyngeal cancer metastatic 11.12 10.66 3 251982 9 110337305
Spinal stenosis 11.11 10.66 78 251907 18978 110318336
Subdural haematoma 11.11 10.66 44 251941 36410 110300904
Underdose 11.08 10.66 92 251893 63462 110273852
Blood bilirubin increased 11.08 10.66 115 251870 75857 110261457
Bile duct stenosis 11.07 10.66 21 251964 2655 110334659
End stage renal disease 11.04 10.66 20 251965 21453 110315861
Plantar fasciitis 11.04 10.66 31 251954 5070 110332244
Abdominal distension 11.03 10.66 309 251676 174794 110162520
Hemiplegia 11.03 10.66 22 251963 22760 110314554
Bone operation 11.02 10.66 8 251977 353 110336961
Complement factor C4 decreased 10.98 10.66 8 251977 355 110336959
Sickle cell anaemia with crisis 10.98 10.66 4 251981 9541 110327773
Injection site pruritus 10.96 10.66 70 251915 51188 110286126
Facial pain 10.91 10.66 66 251919 15273 110322041
Cholecystitis chronic 10.89 10.66 4 251981 9496 110327818
Vaginal lesion 10.88 10.66 8 251977 360 110336954
Metastases to penis 10.88 10.66 3 251982 10 110337304
Klebsiella infection 10.87 10.66 18 251967 19991 110317323
Adenoid cystic carcinoma 10.85 10.66 4 251981 40 110337274
Sexual dysfunction 10.83 10.66 3 251982 8527 110328787
Lymphocele 10.78 10.66 17 251968 1854 110335460
Muscle atrophy 10.71 10.66 59 251926 13195 110324119
Oral mucosal discolouration 10.71 10.66 8 251977 369 110336945
Back disorder 10.70 10.66 83 251902 20839 110316475
Dermo-hypodermitis 10.70 10.66 15 251970 1473 110335841

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BX04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
MeSH PA D050071 Bone Density Conservation Agents
FDA MoA N0000187054 RANK Ligand Blocking Activity
FDA EPC N0000187055 RANK Ligand Inhibitor
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

M05BX Other drugs affecting bone structure and mineralization 8 drugs
aluminium chlorohydrateburosumabcolecalciferolipriflavonemenatetrenoneromosozumabstrontium ranelatevosoritide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Drug-induced osteoporosis indication 14651005
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor ligand superfamily member 11 Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D03684 KEGG_DRUG
4030131 VUID
N0000181718 NUI
4030131 VANDF
CHEBI:749681 CHEBI
CHEMBL1237023 ChEMBL_ID
6886 IUPHAR_LIGAND_ID
DB06643 DRUGBANK_ID
993449 RXNORM
173191 MMSL
27218 MMSL
d07640 MMSL
013441 NDDF
446321003 SNOMEDCT_US
446457007 SNOMEDCT_US
C1690432 UMLSCUI
D000069448 MESH_DESCRIPTOR_UI
8653 INN_ID
4EQZ6YO2HI UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ENOBY HUMAN PRESCRIPTION DRUG LABEL 1 0143-9165 INJECTION 60 mg SUBCUTANEOUS BLA 31 sections
XTRENBO HUMAN PRESCRIPTION DRUG LABEL 1 0143-9166 INJECTION 120 mg SUBCUTANEOUS BLA 28 sections
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
XGEVA HUMAN PRESCRIPTION DRUG LABEL 1 55513-730 INJECTION 120 mg SUBCUTANEOUS BLA 30 sections
WYOST HUMAN PRESCRIPTION DRUG LABEL 1 61314-228 INJECTION 120 mg SUBCUTANEOUS BLA 27 sections
WYOST HUMAN PRESCRIPTION DRUG LABEL 1 61314-228 INJECTION 120 mg SUBCUTANEOUS BLA 27 sections
JUBBONTI HUMAN PRESCRIPTION DRUG LABEL 1 61314-240 INJECTION 60 mg SUBCUTANEOUS BLA 30 sections
JUBBONTI HUMAN PRESCRIPTION DRUG LABEL 1 61314-240 INJECTION 60 mg SUBCUTANEOUS BLA 30 sections
CONEXXENCE HUMAN PRESCRIPTION DRUG LABEL 1 65219-668 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
BOMYNTRA HUMAN PRESCRIPTION DRUG LABEL 1 65219-670 INJECTION 70 mg SUBCUTANEOUS BLA 30 sections
BOMYNTRA HUMAN PRESCRIPTION DRUG LABEL 1 65219-672 INJECTION 70 mg SUBCUTANEOUS BLA 30 sections
OSVYRTI HUMAN PRESCRIPTION DRUG LABEL 1 69448-021 INJECTION 60 mg SUBCUTANEOUS BLA 32 sections
JUBEREQ HUMAN PRESCRIPTION DRUG LABEL 1 69448-022 INJECTION 70 mg SUBCUTANEOUS BLA 27 sections
Oziltus HUMAN PRESCRIPTION DRUG LABEL 1 70121-2701 INJECTION, SOLUTION 70 mg SUBCUTANEOUS BLA 27 sections
Boncresa HUMAN PRESCRIPTION DRUG LABEL 1 70121-2702 INJECTION, SOLUTION 60 mg SUBCUTANEOUS BLA 29 sections
Stoboclo HUMAN PRESCRIPTION DRUG LABEL 1 72606-037 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
Stoboclo HUMAN PRESCRIPTION DRUG LABEL 1 72606-037 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
Osenvelt HUMAN PRESCRIPTION DRUG LABEL 1 72606-038 INJECTION 120 mg SUBCUTANEOUS BLA 31 sections
Denosumab-BMWO HUMAN PRESCRIPTION DRUG LABEL 1 72606-058 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
Denosumab-BMWO HUMAN PRESCRIPTION DRUG LABEL 1 72606-058 INJECTION 60 mg SUBCUTANEOUS BLA 33 sections
Denosumab-BMWO HUMAN PRESCRIPTION DRUG LABEL 1 72606-059 INJECTION 120 mg SUBCUTANEOUS BLA 31 sections
BILDYOS HUMAN PRESCRIPTION DRUG LABEL 1 78206-193 INJECTION, SOLUTION 60 mg SUBCUTANEOUS BLA 33 sections
Bilprevda HUMAN PRESCRIPTION DRUG LABEL 1 78206-195 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 31 sections
BOSAYA HUMAN PRESCRIPTION DRUG LABEL 1 83257-029 INJECTION 60 mg SUBCUTANEOUS BLA 28 sections
AUKELSO HUMAN PRESCRIPTION DRUG LABEL 1 83257-030 INJECTION 120 mg SUBCUTANEOUS BLA 28 sections
OSPOMYV HUMAN PRESCRIPTION DRUG LABEL 1 83457-012 INJECTION, SOLUTION 60 mg SUBCUTANEOUS BLA 32 sections