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luliconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 4813 | 187164-19-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an antifungal that belongs to the azole class, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase, inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TTK,ZAP70 | 42 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,PDK4,PIK3CB | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 14, 2013 | FDA | MEDICIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC18 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| FDA CS | M0002083 | Azoles |
| FDA EPC | N0000175487 | Azole Antifungal |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
| FDA MoA | N0000182140 | Cytochrome P450 2C19 Inhibitors |
| CHEBI has role | CHEBI:35718 | antifungal agent |
Related Drugs by ATC class:
D01AC Imidazole and triazole derivatives 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Tinea corporis | indication | 84849002 | |
| Tinea cruris | indication | 399029005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.91 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1% | LUZU | BAUSCH | N204153 | Nov. 14, 2013 | RX | CREAM | TOPICAL | 9012484 | Sept. 6, 2033 | TREATMENT OF FUNGAL INFECTIONS |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Lanosterol 14-alpha demethylase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01980 | KEGG_DRUG |
| 4033088 | VUID |
| N0000190122 | NUI |
| 4033088 | VANDF |
| CHEBI:34825 | CHEBI |
| CHEMBL2105689 | ChEMBL_ID |
| C112528 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7366 | IUPHAR_LIGAND_ID |
| DB08933 | DRUGBANK_ID |
| RE91AN4S8G | UNII |
| 1482680 | RXNORM |
| 207437 | MMSL |
| 283910 | MMSL |
| 29867 | MMSL |
| 015304 | NDDF |
| 724031004 | SNOMEDCT_US |
| 763571006 | SNOMEDCT_US |
| C1956280 | UMLSCUI |
| 8161 | INN_ID |
| 3003141 | PUBCHEM_CID |
| RE91AN4S8G | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| LULICONAZOLE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68682-850 | CREAM | 10 mg | TOPICAL | NDA | 26 sections |
| Luzu | HUMAN PRESCRIPTION DRUG LABEL | 1 | 99207-850 | CREAM | 10 mg | TOPICAL | NDA | 26 sections |