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| Stem definition | Drug id | CAS RN |
|---|---|---|
| antisense oligonucleotides | 4751 | 160369-77-7 |
| Molecule | Description |
|---|---|
|
Synonyms:
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Fomivirsen is a phosphorothioate oligonucleotide that inhibits human cytomegalovirus (HCMV) replication through an antisense mechanism. The nucleotide sequence of fomivirsen is complementary to a sequence in mRNA transcripts of the major immediate early region 2 (IE2) of HCMV. This region of mRNA encodes several proteins responsible for regulation of viral gene expression that are essential for production of infectious CMV. Binding of fomivirsen to the target mRNA results in inhibition of IE2 protein synthesis, subsequently inhibiting virus replication.
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 26, 1998 | FDA | NOVARTIS |
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| Source | Code | Description |
|---|---|---|
| ATC | S01AD08 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antivirals |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D015335 | Molecular Probes |
| MeSH PA | D016376 | Oligonucleotides, Antisense |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cytomegaloviral retinitis | indication | 22455005 |
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| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Immediate early protein IE1 mRNA | RNA | ANTISENSE INHIBITOR | UNKNOWN | DRUG LABEL |
| ID | Source |
|---|---|
| D02736 | KEGG_DRUG |
| 4021137 | VUID |
| N0000148591 | NUI |
| 144245-52-3 | SECONDARY_CAS_RN |
| 4021137 | VANDF |
| 4024128 | VANDF |
| CHEBI:749580 | CHEBI |
| CHEMBL1201688 | ChEMBL_ID |
| CHEMBL1201512 | ChEMBL_ID |
| C091346 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13533 | IUPHAR_LIGAND_ID |
| DB06759 | DRUGBANK_ID |
| QX5LK7YCHV | UNII |
| 314633 | RXNORM |
| 7946 | MMSL |
| 007678 | NDDF |
| 007679 | NDDF |
| 108868005 | SNOMEDCT_US |
| 108869002 | SNOMEDCT_US |
| 373730007 | SNOMEDCT_US |
| C0292819 | UMLSCUI |
| 7509 | INN_ID |
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