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teduglutide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| glucagon-like peptide (GLP) analogues and agonists | 4718 | 197922-42-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an analogue of human glucagon-like peptide-2 (GLP-2) preserves mucosal integrity by promoting repair and normal growth of the intestine through an increase of villus height and crypt depth
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | P |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 23, 2021 | PMDA | TAKEDA PHARMACEUTICAL COMPANY LIMITED | |
| Aug. 30, 2012 | EMA | NPS Pharma Holdings Limited | |
| Dec. 21, 2012 | FDA | NPS PHARMS INC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vascular device infection | 1482.97 | 23.99 | 342 | 12374 | 11610 | 90604121 |
| Stoma complication | 410.65 | 23.99 | 72 | 12644 | 560 | 90615171 |
| Gastrointestinal stoma output increased | 399.86 | 23.99 | 70 | 12646 | 539 | 90615192 |
| Device related infection | 336.27 | 23.99 | 129 | 12587 | 25657 | 90590074 |
| Device related sepsis | 308.01 | 23.99 | 81 | 12635 | 4712 | 90611019 |
| Abdominal distension | 257.53 | 23.99 | 183 | 12533 | 130418 | 90485313 |
| Product dose omission issue | 246.91 | 23.99 | 251 | 12465 | 291436 | 90324295 |
| Dehydration | 216.91 | 23.99 | 195 | 12521 | 194252 | 90421479 |
| Weight decreased | 203.82 | 23.99 | 258 | 12458 | 379652 | 90236079 |
| Abdominal pain | 200.15 | 23.99 | 261 | 12455 | 395460 | 90220271 |
| Intestinal obstruction | 186.34 | 23.99 | 95 | 12621 | 37036 | 90578695 |
| Gastrointestinal stoma output abnormal | 182.27 | 23.99 | 34 | 12682 | 386 | 90615345 |
| Gastrointestinal stoma complication | 175.34 | 23.99 | 45 | 12671 | 2374 | 90613357 |
| Stoma site pain | 130.83 | 23.99 | 32 | 12684 | 1385 | 90614346 |
| Flatulence | 130.66 | 23.99 | 78 | 12638 | 41289 | 90574442 |
| Sepsis | 129.12 | 23.99 | 142 | 12574 | 179672 | 90436059 |
| Faeces hard | 126.26 | 23.99 | 37 | 12679 | 3205 | 90612526 |
| Hospitalisation | 116.79 | 23.99 | 115 | 12601 | 127985 | 90487746 |
| Insurance issue | 101.84 | 23.99 | 43 | 12673 | 10915 | 90604816 |
| Complication associated with device | 101.15 | 23.99 | 51 | 12665 | 19398 | 90596333 |
| Abnormal faeces | 99.98 | 23.99 | 37 | 12679 | 6645 | 90609086 |
| Inappropriate schedule of product administration | 98.34 | 23.99 | 113 | 12603 | 149820 | 90465911 |
| Small intestinal obstruction | 96.92 | 23.99 | 51 | 12665 | 21183 | 90594548 |
| Obstruction | 90.55 | 23.99 | 30 | 12686 | 3891 | 90611840 |
| Stoma site inflammation | 89.68 | 23.99 | 21 | 12695 | 753 | 90614978 |
| Product availability issue | 89.19 | 23.99 | 35 | 12681 | 7369 | 90608362 |
| Product distribution issue | 88.18 | 23.99 | 29 | 12687 | 3676 | 90612055 |
| Device related bacteraemia | 85.11 | 23.99 | 18 | 12698 | 401 | 90615330 |
| Blood magnesium decreased | 75.35 | 23.99 | 39 | 12677 | 15654 | 90600077 |
| Enterocutaneous fistula | 74.89 | 23.99 | 21 | 12695 | 1553 | 90614178 |
| Stoma site oedema | 74.13 | 23.99 | 13 | 12703 | 101 | 90615630 |
| Stoma site haemorrhage | 73.57 | 23.99 | 20 | 12696 | 1318 | 90614413 |
| Weight fluctuation | 69.61 | 23.99 | 40 | 12676 | 19709 | 90596022 |
| Stoma site dermatitis | 68.01 | 23.99 | 14 | 12702 | 272 | 90615459 |
| COVID-19 | 67.93 | 23.99 | 100 | 12616 | 168743 | 90446988 |
| Gastrointestinal stoma output decreased | 64.58 | 23.99 | 12 | 12704 | 133 | 90615598 |
| Nephrolithiasis | 62.13 | 23.99 | 53 | 12663 | 49032 | 90566699 |
| Off label use | 58.41 | 23.99 | 42 | 12674 | 1102210 | 89513521 |
| Urinary tract infection | 57.36 | 23.99 | 130 | 12586 | 305502 | 90310229 |
| Obstructive defaecation | 57.14 | 23.99 | 12 | 12704 | 258 | 90615473 |
| Vitamin A deficiency | 55.07 | 23.99 | 9 | 12707 | 43 | 90615688 |
| Needle issue | 53.91 | 23.99 | 30 | 12686 | 13904 | 90601827 |
| Weight increased | 52.72 | 23.99 | 153 | 12563 | 417774 | 90197957 |
| Bacteraemia | 52.68 | 23.99 | 35 | 12681 | 22265 | 90593466 |
| Incorrect dose administered | 52.55 | 23.99 | 60 | 12656 | 78870 | 90536861 |
| Duodenal polyp | 52.40 | 23.99 | 11 | 12705 | 236 | 90615495 |
| Urine output increased | 50.98 | 23.99 | 16 | 12700 | 1746 | 90613985 |
| Malnutrition | 50.92 | 23.99 | 32 | 12684 | 18526 | 90597205 |
| Alopecia | 48.93 | 23.99 | 6 | 12710 | 495065 | 90120666 |
| Syringe issue | 48.48 | 23.99 | 19 | 12697 | 3983 | 90611748 |
| Drug ineffective | 46.53 | 23.99 | 77 | 12639 | 1384221 | 89231510 |
| Overgrowth bacterial | 44.48 | 23.99 | 9 | 12707 | 160 | 90615571 |
| Injection site bruising | 44 | 23.99 | 45 | 12671 | 52262 | 90563469 |
| Therapy interrupted | 43.78 | 23.99 | 44 | 12672 | 50064 | 90565667 |
| Parenteral nutrition associated liver disease | 43.07 | 23.99 | 6 | 12710 | 6 | 90615725 |
| Device leakage | 42.77 | 23.99 | 23 | 12693 | 9968 | 90605763 |
| Underweight | 41.80 | 23.99 | 13 | 12703 | 1377 | 90614354 |
| Ileus | 41.59 | 23.99 | 27 | 12689 | 16519 | 90599212 |
| Stoma obstruction | 41.56 | 23.99 | 9 | 12707 | 225 | 90615506 |
| Hypersensitivity | 41.45 | 23.99 | 7 | 12709 | 454670 | 90161061 |
| Fistula | 41.31 | 23.99 | 24 | 12692 | 12065 | 90603666 |
| Rash | 41.22 | 23.99 | 31 | 12685 | 796069 | 89819662 |
| Eructation | 40.93 | 23.99 | 23 | 12693 | 10859 | 90604872 |
| Faecal volume decreased | 40.08 | 23.99 | 9 | 12707 | 267 | 90615464 |
| Arthropathy | 39.96 | 23.99 | 3 | 12713 | 366239 | 90249492 |
| Weight gain poor | 39.65 | 23.99 | 12 | 12704 | 1160 | 90614571 |
| Appetite disorder | 39.02 | 23.99 | 21 | 12695 | 9112 | 90606619 |
| Faecal volume increased | 37.92 | 23.99 | 8 | 12708 | 176 | 90615555 |
| Catheter site inflammation | 37.60 | 23.99 | 11 | 12705 | 946 | 90614785 |
| Increased appetite | 36.64 | 23.99 | 22 | 12694 | 11743 | 90603988 |
| Diarrhoea | 36.13 | 23.99 | 240 | 12476 | 938950 | 89676781 |
| Device occlusion | 35.95 | 23.99 | 20 | 12696 | 9262 | 90606469 |
| Defaecation urgency | 34.31 | 23.99 | 17 | 12699 | 6225 | 90609506 |
| Frequent bowel movements | 34.09 | 23.99 | 41 | 12675 | 56894 | 90558837 |
| Hypertension | 33.90 | 23.99 | 11 | 12705 | 457521 | 90158210 |
| Illness | 33.58 | 23.99 | 49 | 12667 | 81920 | 90533811 |
| Stomal hernia | 33.36 | 23.99 | 8 | 12708 | 318 | 90615413 |
| Peripheral swelling | 33.17 | 23.99 | 130 | 12586 | 412976 | 90202755 |
| Urticaria | 32.90 | 23.99 | 3 | 12713 | 312731 | 90303000 |
| Device related thrombosis | 32.82 | 23.99 | 12 | 12704 | 2081 | 90613650 |
| Drug intolerance | 32.74 | 23.99 | 11 | 12705 | 447580 | 90168151 |
| Hypomagnesaemia | 32.47 | 23.99 | 32 | 12684 | 35556 | 90580175 |
| Vomiting | 31.83 | 23.99 | 204 | 12512 | 788089 | 89827642 |
| Treatment failure | 31.74 | 23.99 | 3 | 12713 | 303925 | 90311806 |
| Small intestine polyp | 31.49 | 23.99 | 4 | 12712 | 0 | 90615731 |
| Blood iron decreased | 30.40 | 23.99 | 23 | 12693 | 17936 | 90597795 |
| Stoma site discharge | 29.70 | 23.99 | 11 | 12705 | 1978 | 90613753 |
| Drug hypersensitivity | 29.65 | 23.99 | 14 | 12702 | 463595 | 90152136 |
| Puncture site erythema | 29.25 | 23.99 | 4 | 12712 | 3 | 90615728 |
| Gastrointestinal fistula | 29.22 | 23.99 | 8 | 12708 | 541 | 90615190 |
| Confusional state | 29.11 | 23.99 | 9 | 12707 | 386196 | 90229535 |
| Hypervolaemia | 29.04 | 23.99 | 29 | 12687 | 32728 | 90583003 |
| Decreased appetite | 29.02 | 23.99 | 117 | 12599 | 376423 | 90239308 |
| Hiccups | 28.53 | 23.99 | 12 | 12704 | 3014 | 90612717 |
| Stomatitis | 27.93 | 23.99 | 3 | 12713 | 274695 | 90341036 |
| Urine output decreased | 27.89 | 23.99 | 19 | 12697 | 12584 | 90603147 |
| Product dose omission in error | 27.71 | 23.99 | 23 | 12693 | 20480 | 90595251 |
| Electrolyte imbalance | 26.74 | 23.99 | 24 | 12692 | 23721 | 90592010 |
| Subileus | 26.39 | 23.99 | 12 | 12704 | 3632 | 90612099 |
| Condition aggravated | 26.18 | 23.99 | 27 | 12689 | 595518 | 90020213 |
| Staphylococcal bacteraemia | 25.97 | 23.99 | 15 | 12701 | 7454 | 90608277 |
| Muscle spasms | 25.92 | 23.99 | 86 | 12630 | 251797 | 90363934 |
| Hernia | 25.81 | 23.99 | 19 | 12697 | 14212 | 90601519 |
| Rheumatoid arthritis | 24.68 | 23.99 | 10 | 12706 | 362604 | 90253127 |
| Stoma site abscess | 24.61 | 23.99 | 6 | 12710 | 256 | 90615475 |
| Abdominal pain upper | 24.53 | 23.99 | 102 | 12614 | 332572 | 90283159 |
| Feeding disorder | 24.40 | 23.99 | 20 | 12696 | 17492 | 90598239 |
| Catheter site granuloma | 24.32 | 23.99 | 4 | 12712 | 20 | 90615711 |
| Hypoaesthesia | 24.26 | 23.99 | 7 | 12709 | 314203 | 90301528 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vascular device infection | 1554.97 | 26.05 | 326 | 6955 | 5784 | 42608270 |
| Device related infection | 360.46 | 26.05 | 134 | 7147 | 20145 | 42593909 |
| Stoma complication | 275.51 | 26.05 | 52 | 7229 | 511 | 42613543 |
| Device related sepsis | 266.42 | 26.05 | 72 | 7209 | 3815 | 42610239 |
| Weight decreased | 140.93 | 26.05 | 175 | 7106 | 207773 | 42406281 |
| Gastrointestinal stoma output increased | 131.87 | 26.05 | 27 | 7254 | 415 | 42613639 |
| Product dose omission issue | 120.98 | 26.05 | 140 | 7141 | 154225 | 42459829 |
| Complication associated with device | 114.31 | 26.05 | 43 | 7238 | 6638 | 42607416 |
| Dehydration | 101.78 | 26.05 | 123 | 7158 | 141644 | 42472410 |
| Device breakage | 98.68 | 26.05 | 33 | 7248 | 3616 | 42610438 |
| Stoma site haemorrhage | 92.22 | 26.05 | 24 | 7257 | 1095 | 42612959 |
| Nephrolithiasis | 88.66 | 26.05 | 63 | 7218 | 36767 | 42577287 |
| Abnormal faeces | 88.46 | 26.05 | 31 | 7250 | 3910 | 42610144 |
| Hospitalisation | 87.76 | 26.05 | 84 | 7197 | 74246 | 42539808 |
| Duodenal polyp | 86.76 | 26.05 | 18 | 7263 | 296 | 42613758 |
| Abdominal distension | 84.55 | 26.05 | 81 | 7200 | 71654 | 42542400 |
| Weight increased | 77.91 | 26.05 | 94 | 7187 | 107889 | 42506165 |
| Abdominal pain | 72.33 | 26.05 | 122 | 7159 | 190349 | 42423705 |
| Flatulence | 69.86 | 26.05 | 47 | 7234 | 25105 | 42588949 |
| Gastrointestinal stoma complication | 66.75 | 26.05 | 20 | 7261 | 1533 | 42612521 |
| Catheter site infection | 64.43 | 26.05 | 23 | 7258 | 3060 | 42610994 |
| Gastrointestinal stoma output abnormal | 63.90 | 26.05 | 9 | 7272 | 7 | 42614047 |
| Large intestine polyp | 62.86 | 26.05 | 31 | 7250 | 9234 | 42604820 |
| Enterocutaneous fistula | 61.90 | 26.05 | 18 | 7263 | 1243 | 42612811 |
| Intestinal obstruction | 57.49 | 26.05 | 43 | 7238 | 27115 | 42586939 |
| COVID-19 | 53.15 | 26.05 | 81 | 7200 | 115867 | 42498187 |
| Gastric polyps | 52.35 | 26.05 | 17 | 7264 | 1698 | 42612356 |
| Weight fluctuation | 46.69 | 26.05 | 22 | 7259 | 5929 | 42608125 |
| Stoma site oedema | 45.11 | 26.05 | 7 | 7274 | 17 | 42614037 |
| Device malfunction | 41.49 | 26.05 | 26 | 7255 | 12301 | 42601753 |
| Insurance issue | 41.09 | 26.05 | 18 | 7263 | 4098 | 42609956 |
| Device dislocation | 40.97 | 26.05 | 22 | 7259 | 7809 | 42606245 |
| Faecal volume decreased | 40.27 | 26.05 | 9 | 7272 | 213 | 42613841 |
| Gastrointestinal bacterial overgrowth | 38.70 | 26.05 | 8 | 7273 | 129 | 42613925 |
| Product distribution issue | 38.38 | 26.05 | 14 | 7267 | 1980 | 42612074 |
| Inability to afford medication | 37.48 | 26.05 | 14 | 7267 | 2116 | 42611938 |
| Stoma site pain | 37.37 | 26.05 | 11 | 7270 | 792 | 42613262 |
| Faeces hard | 36.69 | 26.05 | 13 | 7268 | 1691 | 42612363 |
| Weight gain poor | 35.85 | 26.05 | 12 | 7269 | 1317 | 42612737 |
| Malnutrition | 35.24 | 26.05 | 25 | 7256 | 14517 | 42599537 |
| Device related thrombosis | 34.86 | 26.05 | 12 | 7269 | 1433 | 42612621 |
| Drug ineffective | 34.85 | 26.05 | 34 | 7247 | 630163 | 41983891 |
| Device related bacteraemia | 34.69 | 26.05 | 10 | 7271 | 669 | 42613385 |
| Off label use | 34.65 | 26.05 | 35 | 7246 | 638300 | 41975754 |
| Product use issue | 34.25 | 26.05 | 53 | 7228 | 76698 | 42537356 |
| Product availability issue | 33.68 | 26.05 | 15 | 7266 | 3552 | 42610502 |
| Gastrointestinal stoma output decreased | 33.46 | 26.05 | 7 | 7274 | 120 | 42613934 |
| Gastroenteritis | 32.49 | 26.05 | 25 | 7256 | 16424 | 42597630 |
| Urine output increased | 30.79 | 26.05 | 11 | 7270 | 1465 | 42612589 |
| Injection site bruising | 30.70 | 26.05 | 21 | 7260 | 11504 | 42602550 |
| Obstruction | 29.14 | 26.05 | 13 | 7268 | 3090 | 42610964 |
| Sepsis | 28.85 | 26.05 | 87 | 7194 | 199247 | 42414807 |
| Urinary tract infection | 27.96 | 26.05 | 56 | 7225 | 99228 | 42514826 |
| Vascular device occlusion | 27.71 | 26.05 | 7 | 7274 | 283 | 42613771 |
| Fistula | 27.41 | 26.05 | 17 | 7264 | 7895 | 42606159 |
| Inappropriate schedule of product administration | 26.89 | 26.05 | 54 | 7227 | 95848 | 42518206 |
| Iron deficiency | 26.76 | 26.05 | 19 | 7262 | 11042 | 42603012 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vascular device infection | 2624.92 | 21.18 | 586 | 16149 | 15926 | 110556638 |
| Device related infection | 676.06 | 21.18 | 246 | 16489 | 39273 | 110533291 |
| Device related sepsis | 571.78 | 21.18 | 148 | 16587 | 7499 | 110565065 |
| Stoma complication | 519.12 | 21.18 | 96 | 16639 | 955 | 110571609 |
| Gastrointestinal stoma output increased | 415.39 | 21.18 | 79 | 16656 | 925 | 110571639 |
| Dehydration | 255.87 | 21.18 | 260 | 16475 | 279251 | 110293313 |
| Product dose omission issue | 251.32 | 21.18 | 275 | 16460 | 321507 | 110251057 |
| Abdominal distension | 241.88 | 21.18 | 205 | 16530 | 174898 | 110397666 |
| Weight decreased | 211.32 | 21.18 | 304 | 16431 | 467753 | 110104811 |
| Complication associated with device | 201.42 | 21.18 | 85 | 16650 | 19988 | 110552576 |
| Gastrointestinal stoma output abnormal | 197.63 | 21.18 | 37 | 16698 | 395 | 110572169 |
| Abdominal pain | 195.70 | 21.18 | 308 | 16427 | 512681 | 110059883 |
| Gastrointestinal stoma complication | 181.06 | 21.18 | 50 | 16685 | 3239 | 110569325 |
| Intestinal obstruction | 180.71 | 21.18 | 108 | 16627 | 53119 | 110519445 |
| Abnormal faeces | 155.86 | 21.18 | 57 | 16678 | 9179 | 110563385 |
| Faeces hard | 142.67 | 21.18 | 44 | 16691 | 4202 | 110568362 |
| Duodenal polyp | 142.20 | 21.18 | 29 | 16706 | 496 | 110572068 |
| Flatulence | 137.16 | 21.18 | 90 | 16645 | 52059 | 110520505 |
| Enterocutaneous fistula | 131.03 | 21.18 | 36 | 16699 | 2287 | 110570277 |
| Sepsis | 130.75 | 21.18 | 201 | 16534 | 327145 | 110245419 |
| Stoma site haemorrhage | 129.90 | 21.18 | 36 | 16699 | 2362 | 110570202 |
| Stoma site pain | 127.50 | 21.18 | 34 | 16701 | 1929 | 110570635 |
| Nephrolithiasis | 122.21 | 21.18 | 92 | 16643 | 66120 | 110506444 |
| Insurance issue | 106.65 | 21.18 | 45 | 16690 | 10567 | 110561997 |
| Device related bacteraemia | 102.63 | 21.18 | 26 | 16709 | 1204 | 110571360 |
| COVID-19 | 101.33 | 21.18 | 153 | 16582 | 244907 | 110327657 |
| Weight fluctuation | 91.27 | 21.18 | 51 | 16684 | 22094 | 110550470 |
| Off label use | 90.73 | 21.18 | 58 | 16677 | 1500127 | 109072437 |
| Device breakage | 83.29 | 21.18 | 41 | 16694 | 13728 | 110558836 |
| Small intestinal obstruction | 83.23 | 21.18 | 55 | 16680 | 32158 | 110540406 |
| Product availability issue | 81.10 | 21.18 | 34 | 16701 | 7856 | 110564708 |
| Stoma site oedema | 79.93 | 21.18 | 14 | 16721 | 99 | 110572465 |
| Gastrointestinal stoma output decreased | 79.81 | 21.18 | 16 | 16719 | 250 | 110572314 |
| Bacteraemia | 78.42 | 21.18 | 59 | 16676 | 42331 | 110530233 |
| Stoma site inflammation | 77.16 | 21.18 | 20 | 16715 | 1015 | 110571549 |
| Obstruction | 77.10 | 21.18 | 30 | 16705 | 5722 | 110566842 |
| Large intestine polyp | 76.79 | 21.18 | 40 | 16695 | 15077 | 110557487 |
| Drug ineffective | 75.20 | 21.18 | 72 | 16663 | 1520468 | 109052096 |
| Malnutrition | 73.95 | 21.18 | 48 | 16687 | 27231 | 110545333 |
| Urinary tract infection | 73.18 | 21.18 | 156 | 16579 | 326126 | 110246438 |
| Stoma site dermatitis | 72.11 | 21.18 | 15 | 16720 | 284 | 110572280 |
| Catheter site infection | 70.77 | 21.18 | 31 | 16704 | 7969 | 110564595 |
| Product distribution issue | 70.28 | 21.18 | 26 | 16709 | 4320 | 110568244 |
| Faecal volume decreased | 66.85 | 21.18 | 15 | 16720 | 410 | 110572154 |
| Device related thrombosis | 64.52 | 21.18 | 23 | 16712 | 3439 | 110569125 |
| Gastric polyps | 64.23 | 21.18 | 26 | 16709 | 5497 | 110567067 |
| Weight increased | 63.24 | 21.18 | 172 | 16563 | 419472 | 110153092 |
| Drug interaction | 63.17 | 21.18 | 3 | 16732 | 500180 | 110072384 |
| Fistula | 62.40 | 21.18 | 35 | 16700 | 15264 | 110557300 |
| Inappropriate schedule of product administration | 62.26 | 21.18 | 111 | 16624 | 203526 | 110369038 |
| Device malfunction | 62.08 | 21.18 | 42 | 16693 | 25516 | 110547048 |
| Vitamin A deficiency | 61.99 | 21.18 | 12 | 16723 | 155 | 110572409 |
| Urine output increased | 61.51 | 21.18 | 21 | 16714 | 2765 | 110569799 |
| Weight gain poor | 57.74 | 21.18 | 17 | 16718 | 1385 | 110571179 |
| Toxicity to various agents | 57.26 | 21.18 | 4 | 16731 | 480551 | 110092013 |
| Obstructive defaecation | 56.60 | 21.18 | 12 | 16723 | 250 | 110572314 |
| Blood magnesium decreased | 56.21 | 21.18 | 36 | 16699 | 19960 | 110552604 |
| Needle issue | 52.34 | 21.18 | 33 | 16702 | 17807 | 110554757 |
| Hospitalisation | 50.55 | 21.18 | 83 | 16652 | 142410 | 110430154 |
| Gastroenteritis | 50.54 | 21.18 | 44 | 16691 | 38756 | 110533808 |
| Gastrointestinal bacterial overgrowth | 50.34 | 21.18 | 13 | 16722 | 650 | 110571914 |
| Device occlusion | 49.40 | 21.18 | 30 | 16705 | 15155 | 110557409 |
| Rash | 47.74 | 21.18 | 33 | 16702 | 820931 | 109751633 |
| Incorrect dose administered | 47.51 | 21.18 | 68 | 16667 | 103573 | 110468991 |
| Small intestine polyp | 46.53 | 21.18 | 8 | 16727 | 50 | 110572514 |
| Iron deficiency | 46.40 | 21.18 | 31 | 16704 | 18445 | 110554119 |
| Device leakage | 45.37 | 21.18 | 29 | 16706 | 16019 | 110556545 |
| Vascular device occlusion | 45.32 | 21.18 | 12 | 16723 | 662 | 110571902 |
| Condition aggravated | 44.79 | 21.18 | 28 | 16707 | 734808 | 109837756 |
| Frequent bowel movements | 43.75 | 21.18 | 54 | 16681 | 71336 | 110501228 |
| Injection site bruising | 43.68 | 21.18 | 46 | 16689 | 51217 | 110521347 |
| Underweight | 43.67 | 21.18 | 14 | 16721 | 1516 | 110571048 |
| Device dislocation | 43.41 | 21.18 | 37 | 16698 | 31667 | 110540897 |
| Puncture site erythema | 42.74 | 21.18 | 7 | 16728 | 31 | 110572533 |
| Ileus | 42.36 | 21.18 | 36 | 16699 | 30693 | 110541871 |
| Gastrointestinal tract adenoma | 42.10 | 21.18 | 11 | 16724 | 576 | 110571988 |
| Subileus | 41.43 | 21.18 | 20 | 16715 | 6417 | 110566147 |
| Hypersensitivity | 41.30 | 21.18 | 6 | 16729 | 403992 | 110168572 |
| Parenteral nutrition associated liver disease | 40.90 | 21.18 | 6 | 16729 | 10 | 110572554 |
| Confusional state | 39.53 | 21.18 | 11 | 16724 | 468669 | 110103895 |
| Staphylococcal bacteraemia | 39.52 | 21.18 | 27 | 16708 | 16661 | 110555903 |
| Stoma obstruction | 38.48 | 21.18 | 9 | 16726 | 297 | 110572267 |
| Catheter site inflammation | 38.09 | 21.18 | 12 | 16723 | 1228 | 110571336 |
| Illness | 37.79 | 21.18 | 54 | 16681 | 82117 | 110490447 |
| Vitamin D deficiency | 36.94 | 21.18 | 27 | 16708 | 18525 | 110554039 |
| Syringe issue | 36.71 | 21.18 | 21 | 16714 | 9504 | 110563060 |
| Gastrointestinal fistula | 36.49 | 21.18 | 11 | 16724 | 972 | 110571592 |
| Hypertension | 36.12 | 21.18 | 16 | 16719 | 510068 | 110062496 |
| Hypokalaemia | 36.06 | 21.18 | 83 | 16652 | 182365 | 110390199 |
| Therapy interrupted | 36.00 | 21.18 | 41 | 16694 | 49781 | 110522783 |
| Alopecia | 35.95 | 21.18 | 6 | 16729 | 364747 | 110207817 |
| Drug hypersensitivity | 35.87 | 21.18 | 12 | 16723 | 454078 | 110118486 |
| Staphylococcal infection | 35.19 | 21.18 | 48 | 16687 | 69896 | 110502668 |
| Urticaria | 34.35 | 21.18 | 4 | 16731 | 318853 | 110253711 |
| Hypomagnesaemia | 34.34 | 21.18 | 44 | 16691 | 60326 | 110512238 |
| Bile duct stone | 32.97 | 21.18 | 17 | 16718 | 6272 | 110566292 |
| Hypervitaminosis | 32.13 | 21.18 | 6 | 16729 | 63 | 110572501 |
| Stoma site discharge | 31.96 | 21.18 | 13 | 16722 | 2782 | 110569782 |
| Biliary dilatation | 31.91 | 21.18 | 14 | 16721 | 3611 | 110568953 |
| Eructation | 31.54 | 21.18 | 22 | 16713 | 14035 | 110558529 |
| Product use complaint | 31.26 | 21.18 | 14 | 16721 | 3789 | 110568775 |
| Treatment failure | 31.08 | 21.18 | 3 | 16732 | 277231 | 110295333 |
| Cholecystitis | 31.01 | 21.18 | 28 | 16707 | 25854 | 110546710 |
| Defaecation urgency | 30.31 | 21.18 | 18 | 16717 | 8729 | 110563835 |
| Increased appetite | 30.28 | 21.18 | 22 | 16713 | 14955 | 110557609 |
| Vomiting | 30.16 | 21.18 | 238 | 16497 | 910437 | 109662127 |
| Renal colic | 30.04 | 21.18 | 13 | 16722 | 3245 | 110569319 |
| Electrolyte imbalance | 29.38 | 21.18 | 32 | 16703 | 36996 | 110535568 |
| Dyspnoea | 29.36 | 21.18 | 79 | 16656 | 1106793 | 109465771 |
| Overgrowth bacterial | 29.02 | 21.18 | 7 | 16728 | 264 | 110572300 |
| Musculoskeletal stiffness | 28.95 | 21.18 | 4 | 16731 | 279818 | 110292746 |
| Urine output decreased | 28.87 | 21.18 | 24 | 16711 | 19852 | 110552712 |
| Stomal hernia | 28.43 | 21.18 | 8 | 16727 | 555 | 110572009 |
| Drug intolerance | 28.38 | 21.18 | 13 | 16722 | 406499 | 110166065 |
| Hypervolaemia | 28.05 | 21.18 | 36 | 16699 | 49424 | 110523140 |
| Systemic lupus erythematosus | 27.87 | 21.18 | 3 | 16732 | 254335 | 110318229 |
| Product leakage | 27.35 | 21.18 | 10 | 16725 | 1608 | 110570956 |
| Product dose omission in error | 27.31 | 21.18 | 25 | 16710 | 23487 | 110549077 |
| Faecal volume increased | 27.22 | 21.18 | 7 | 16728 | 344 | 110572220 |
| Pruritus | 26.92 | 21.18 | 29 | 16706 | 581531 | 109991033 |
| Neutropenia | 26.12 | 21.18 | 12 | 16723 | 374608 | 110197956 |
| Magnesium deficiency | 25.80 | 21.18 | 8 | 16727 | 777 | 110571787 |
| Hypotension | 25.51 | 21.18 | 25 | 16710 | 523824 | 110048740 |
| Blood iron decreased | 25.44 | 21.18 | 22 | 16713 | 19192 | 110553372 |
| Feeding disorder | 25.38 | 21.18 | 23 | 16712 | 21339 | 110551225 |
| Hypoaesthesia | 25.34 | 21.18 | 8 | 16727 | 314215 | 110258349 |
| Pancreatic cyst | 25.29 | 21.18 | 11 | 16724 | 2779 | 110569785 |
| Gastrointestinal sounds abnormal | 25.17 | 21.18 | 14 | 16721 | 6004 | 110566560 |
| Diarrhoea | 25.17 | 21.18 | 273 | 16462 | 1139232 | 109433332 |
| Abdominal pain upper | 25.10 | 21.18 | 112 | 16623 | 348999 | 110223565 |
| Pyrexia | 25.07 | 21.18 | 226 | 16509 | 898039 | 109674525 |
| Peripheral swelling | 24.23 | 21.18 | 123 | 16612 | 403911 | 110168653 |
| Disease progression | 24.07 | 21.18 | 4 | 16731 | 244030 | 110328534 |
| Cholelithiasis | 23.91 | 21.18 | 38 | 16697 | 63384 | 110509180 |
| Completed suicide | 23.85 | 21.18 | 4 | 16731 | 242377 | 110330187 |
| Therapeutic product effect incomplete | 23.62 | 21.18 | 3 | 16732 | 223802 | 110348762 |
| Stomatitis | 23.42 | 21.18 | 6 | 16729 | 270236 | 110302328 |
| Intestinal polyp | 23.41 | 21.18 | 10 | 16725 | 2419 | 110570145 |
| Colostomy infection | 23.39 | 21.18 | 3 | 16732 | 0 | 110572564 |
| Polyp | 23.28 | 21.18 | 16 | 16719 | 9964 | 110562600 |
| Anal stenosis | 23.26 | 21.18 | 7 | 16728 | 615 | 110571949 |
| Anastomotic ulcer | 23.25 | 21.18 | 8 | 16727 | 1078 | 110571486 |
| Rhinovirus infection | 23.12 | 21.18 | 17 | 16718 | 11772 | 110560792 |
| Muscle spasms | 22.89 | 21.18 | 93 | 16642 | 278064 | 110294500 |
| Oedema peripheral | 22.54 | 21.18 | 104 | 16631 | 328556 | 110244008 |
| Platelet count decreased | 22.24 | 21.18 | 4 | 16731 | 230439 | 110342125 |
| Haematochezia | 22.20 | 21.18 | 52 | 16683 | 115472 | 110457092 |
| Product use in unapproved indication | 22.18 | 21.18 | 21 | 16714 | 447356 | 110125208 |
| Lumbar vertebral fracture | 22.16 | 21.18 | 15 | 16720 | 9116 | 110563448 |
| Pancreatic disorder | 21.68 | 21.18 | 11 | 16724 | 3923 | 110568641 |
| Dizziness | 21.51 | 21.18 | 46 | 16689 | 698147 | 109874417 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A16AX08 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products |
| FDA Chemical/Ingredient | N0000175140 | Glucagon-Like Peptide 2 |
| FDA Chemical/Ingredient | N0000175452 | Analogs/Derivatives |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D011837 | Radiation-Protective Agents |
| MeSH PA | D020011 | Protective Agents |
| FDA MoA | N0000190990 | Glucagon-like Peptide-2 (GLP-2) Agonists |
| FDA EPC | N0000190992 | GLP-2 Analog |
| CHEBI has role | CHEBI:22586 | antioxidant |
| CHEBI has role | CHEBI:25212 | metabolite |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:50267 | protective agent |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:72311 | glucagon-like peptide-2 receptor agonist |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Related Drugs by ATC class:
A16AX Various alimentary tract and metabolism products 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Short bowel syndrome | indication | 26629001 | DOID:10605 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.81 | acidic |
| pKa2 | 3.1 | acidic |
| pKa3 | 3.51 | acidic |
| pKa4 | 3.79 | acidic |
| pKa5 | 4.07 | acidic |
| pKa6 | 4.58 | acidic |
| pKa7 | 5.16 | acidic |
| pKa8 | 12.12 | acidic |
| pKa9 | 12.14 | acidic |
| pKa10 | 12.47 | acidic |
| pKa11 | 12.53 | acidic |
| pKa12 | 12.69 | acidic |
| pKa13 | 12.83 | acidic |
| pKa14 | 12.86 | acidic |
| pKa15 | 12.87 | acidic |
| pKa16 | 13.05 | acidic |
| pKa17 | 13.1 | acidic |
| pKa18 | 13.22 | acidic |
| pKa19 | 13.41 | acidic |
| pKa20 | 13.45 | acidic |
| pKa21 | 13.46 | acidic |
| pKa22 | 13.54 | acidic |
| pKa23 | 13.75 | acidic |
| pKa24 | 13.8 | acidic |
| pKa25 | 13.87 | acidic |
| pKa26 | 13.9 | acidic |
| pKa27 | 11.08 | Basic |
| pKa28 | 10.48 | Basic |
| pKa29 | 7.86 | Basic |
| pKa30 | 5.98 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 5MG/VIAL | GATTEX KIT | TAKEDA PHARMS USA | N203441 | Dec. 21, 2012 | RX | POWDER | SUBCUTANEOUS | 7847061 | Nov. 1, 2025 | TREATMENT OF ADULT PATIENTS WITH SHORT BOWEL SYNDROME WHO ARE DEPENDENT ON PARENTERAL SUPPORT |
| 5MG/VIAL | GATTEX KIT | TAKEDA PHARMS USA | N203441 | Dec. 21, 2012 | RX | POWDER | SUBCUTANEOUS | 9060992 | Nov. 1, 2025 | TREATMENT OF ADULT PATIENTS WITH SHORT BOWEL SYNDROME WHO ARE DEPENDENT ON PARENTERAL SUPPORT |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 5MG/VIAL | GATTEX KIT | TAKEDA PHARMS USA | N203441 | Dec. 21, 2012 | RX | POWDER | SUBCUTANEOUS | May 16, 2026 | TREATMENT OF PEDIATRIC PATIENTS 1 YEAR OF AGE AND OLDER WITH SHORT BOWEL SYNDROME (SBS) WHO ARE DEPENDENT ON PARENTERAL SUPPORT |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 2 receptor | GPCR | AGONIST | EC50 | 10.05 | CHEMBL | CHEMBL | |||
| Glucagon-like peptide 2 receptor | GPCR | EC50 | 10.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D06053 | KEGG_DRUG |
| 4032133 | VUID |
| N0000186572 | NUI |
| 4032133 | VANDF |
| CHEBI:72305 | CHEBI |
| CHEMBL2104987 | ChEMBL_ID |
| C494910 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7049 | IUPHAR_LIGAND_ID |
| 8444 | INN_ID |
| DB08900 | DRUGBANK_ID |
| 7M19191IKG | UNII |
| 1364468 | RXNORM |
| 196699 | MMSL |
| 29024 | MMSL |
| d07938 | MMSL |
| 014819 | NDDF |
| 710807004 | SNOMEDCT_US |
| 715636000 | SNOMEDCT_US |
| C1530889 | UMLSCUI |
| 16139605 | PUBCHEM_CID |
| C438272 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7M19191IKG | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Gattex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68875-0101 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 5 mg | SUBCUTANEOUS | NDA | 31 sections |