camphor 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
470 76-22-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • camphor
  • alphanon
  • borneo camphor
  • DL-Camphor
  • root bark oil
  • 2-Bornanone
  • 2-Camphanone
  • camphor (synthetic)
  • camphor (natural)
  • camphor, (synthetic)
  • camphor, (+/-)-
  • camphora
A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
  • Molecular weight: 152.24
  • Formula: C10H16O
  • CLOGP: 2.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS: -2.24
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 40
kinase-selectivity-class EIF2AK3,GRK2,PDK2 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint dislocation 152.13 14.82 104 19722 44478 90564143
Seronegative arthritis 137.52 14.82 71 19755 18163 90590458
Methaemoglobinaemia 137.02 14.82 46 19780 3969 90604652
Prescribed underdose 117.82 14.82 111 19715 74908 90533713
Joint stiffness 110.36 14.82 109 19717 77933 90530688
Lupus vulgaris 93.32 14.82 78 19748 44981 90563640
Walking aid user 89.57 14.82 69 19757 35437 90573184
Wound infection 89.01 14.82 113 19713 106289 90502332
Retinitis 88.95 14.82 71 19755 38387 90570234
Laryngitis 87.24 14.82 79 19747 50674 90557947
Lupus-like syndrome 83.89 14.82 76 19750 48770 90559851
Type 2 diabetes mellitus 83.33 14.82 155 19671 203089 90405532
Upper respiratory tract infection 82.62 14.82 120 19706 128198 90480423
Hypercholesterolaemia 81.01 14.82 105 19721 100787 90507834
Osteoporosis 79.92 14.82 102 19724 96429 90512192
Sciatica 79.06 14.82 104 19722 101278 90507343
Visual impairment 76.94 14.82 118 19708 132247 90476374
Road traffic accident 74.20 14.82 104 19722 107522 90501099
Adjustment disorder with depressed mood 72.41 14.82 75 19751 56678 90551943
Autoimmune disorder 63.37 14.82 81 19745 76663 90531958
Osteoarthritis 63.06 14.82 135 19691 195595 90413026
Broncholithiasis 60.83 14.82 14 19812 293 90608328
Lymph node calcification 57.50 14.82 14 19812 376 90608245
Joint range of motion decreased 56.24 14.82 104 19722 135539 90473082
Anti-cyclic citrullinated peptide antibody 56.10 14.82 47 19779 27174 90581447
Prescribed overdose 55.26 14.82 86 19740 97539 90511082
Psoriasis 53.55 14.82 107 19719 147647 90460974
Hepatic cirrhosis 51.02 14.82 66 19760 63187 90545434
Exostosis 50.16 14.82 60 19766 53074 90555547
Lower limb fracture 49.67 14.82 76 19750 84937 90523684
Urticaria thermal 48.40 14.82 13 19813 520 90608101
Liver function test increased 48.37 14.82 75 19751 84780 90523841
Hip arthroplasty 47.18 14.82 70 19756 76138 90532483
Disability 46.92 14.82 51 19775 40694 90567927
Urticaria 46.28 14.82 162 19664 312572 90296049
Foot deformity 46.18 14.82 61 19765 59590 90549031
Bone erosion 45.40 14.82 57 19769 52964 90555657
Dislocation of vertebra 44.51 14.82 58 19768 55910 90552711
Amnesia 43.48 14.82 82 19744 108423 90500198
Spinal fusion surgery 42.69 14.82 29 19797 12254 90596367
Deep vein thrombosis postoperative 42.35 14.82 64 19762 70745 90537876
Red blood cell sedimentation rate increased 41.59 14.82 69 19757 82526 90526095
Pulmonary fibrosis 41.54 14.82 80 19746 107423 90501198
Spondylitis 41.20 14.82 30 19796 14148 90594473
Swollen joint count increased 40.84 14.82 81 19745 111125 90497496
Knee arthroplasty 38.59 14.82 67 19759 83115 90525506
Grip strength decreased 38.38 14.82 71 19755 92505 90516116
Administration site erythema 37.40 14.82 12 19814 897 90607724
Irritable bowel syndrome 36.51 14.82 114 19712 207334 90401287
Ear infection 36.08 14.82 59 19767 69716 90538905
Mobility decreased 34.61 14.82 127 19699 250607 90358014
Bronchial wall thickening 34.10 14.82 14 19812 2117 90606504
Delirium 33.59 14.82 72 19754 104287 90504334
Fibromyalgia 33.25 14.82 110 19716 206159 90402462
Wheezing 32.36 14.82 120 19706 237960 90370661
Lichen nitidus 32.01 14.82 7 19819 115 90608506
Blood cholesterol increased 31.82 14.82 109 19717 207903 90400718
Breast cancer stage III 31.59 14.82 62 19764 84385 90524236
Oedema 31.56 14.82 106 19720 200189 90408432
Gait inability 30.04 14.82 85 19741 146371 90462250
Hypoaesthesia 29.17 14.82 141 19685 314069 90294552
Tachycardia 28.99 14.82 88 19738 157585 90451036
Asthma 28.78 14.82 117 19709 242043 90366578
Contusion 28.78 14.82 120 19706 251096 90357525
Injury 28.10 14.82 101 19725 197248 90411373
Drug ineffective 28.02 14.82 183 19643 1384115 89224506
Muscular weakness 27.11 14.82 103 19723 206563 90402058
C-reactive protein increased 26.82 14.82 94 19732 181295 90427326
Rheumatic fever 26.79 14.82 84 19742 153037 90455584
Liver injury 26.63 14.82 90 19736 170477 90438144
Pigmentation disorder 25.45 14.82 16 19810 5933 90602688
Drug-induced liver injury 25.34 14.82 59 19767 90259 90518362
Nail bed tenderness 24.15 14.82 7 19819 371 90608250
Wound 21.96 14.82 127 19699 302853 90305768
Electrocardiogram PR shortened 21.68 14.82 7 19819 534 90608087
Oedema peripheral 20.61 14.82 111 19715 257804 90350817
Scratch 20.25 14.82 17 19809 9849 90598772
Helicobacter infection 19.06 14.82 99 19727 226751 90381870
Weight decreased 18.91 14.82 145 19681 379765 90228856
Psoriatic arthropathy 18.74 14.82 99 19727 228236 90380385
Sinusitis 18.23 14.82 133 19693 342955 90265666
Rheumatoid factor positive 18.10 14.82 80 19746 171570 90437051
Nasopharyngitis 17.88 14.82 151 19675 406953 90201668
Vitamin B12 deficiency 17.68 14.82 14 19812 7472 90601149
Cerebrovascular accident 17.44 14.82 3 19823 123530 90485091
Dizziness postural 17.36 14.82 15 19811 9038 90599583
Sexual abuse 17.33 14.82 5 19821 261 90608360
Disinhibition 17.03 14.82 7 19819 1061 90607560
Muscle injury 16.90 14.82 80 19746 176574 90432047
Weight increased 16.79 14.82 152 19674 417775 90190846
Neutropenia 16.41 14.82 15 19811 224889 90383732
Hypotension 16.19 14.82 29 19797 325368 90283253
Disease progression 16.16 14.82 7 19819 156608 90452013
Pruritus 15.59 14.82 184 19642 541341 90067280
Contraindicated product administered 15.51 14.82 29 19797 320110 90288511
Soft tissue necrosis 15.38 14.82 6 19820 794 90607827
Autonomic neuropathy 15.08 14.82 7 19819 1420 90607201
Impaired healing 14.94 14.82 95 19731 234104 90374517

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 157.14 17.86 45 3739 5729 42611822
Choroiditis 67.08 17.86 17 3767 1358 42616193
Endophthalmitis 59.01 17.86 20 3764 4413 42613138
Visual acuity reduced 40.54 17.86 23 3761 17527 42600024
Intraocular pressure increased 37.93 17.86 16 3768 6417 42611134
Completed suicide 33.50 17.86 42 3742 96423 42521128
Pruritus 32.25 17.86 59 3725 188712 42428839
Eye pain 30.64 17.86 19 3765 17011 42600540
Condition aggravated 28.69 17.86 68 3716 260686 42356865
Haemolysis 26.07 17.86 14 3770 9575 42607976
Anticholinergic syndrome 24.45 17.86 8 3776 1581 42615970
Chondritis 23.27 17.86 5 3779 193 42617358
Skin infection 20.86 17.86 12 3772 9368 42608183
Erythema multiforme 20.18 17.86 12 3772 9965 42607586
Cellulitis 20.06 17.86 26 3758 61559 42555992
Post inflammatory pigmentation change 18.75 17.86 5 3779 487 42617064
Dermatitis exfoliative 18.49 17.86 10 3774 6937 42610614

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 291.34 13.25 88 14401 9080 110565730
Broncholithiasis 62.81 13.25 13 14476 279 110574531
Lymph node calcification 56.68 13.25 13 14476 456 110574354
Urticaria thermal 55.07 13.25 13 14476 518 110574292
Choroiditis 53.43 13.25 16 14473 1599 110573211
Administration site erythema 52.15 13.25 12 14477 427 110574383
Pruritus 39.74 13.25 166 14323 581394 109993416
Endophthalmitis 36.70 13.25 19 14470 8168 110566642
Lichen nitidus 34.06 13.25 7 14482 145 110574665
Scratch 33.50 13.25 21 14468 12958 110561852
Bronchial wall thickening 32.04 13.25 13 14476 3194 110571616
Completed suicide 30.54 13.25 85 14404 242296 110332514
Sciatica 30.27 13.25 48 14441 92351 110482459
Pigmentation disorder 30.02 13.25 16 14473 7295 110567515
Adjustment disorder with depressed mood 28.71 13.25 32 14457 43851 110530959
Autoimmune disorder 28.67 13.25 39 14450 65444 110509366
Soft tissue necrosis 27.60 13.25 9 14480 1189 110573621
Nail bed tenderness 27.60 13.25 7 14482 377 110574433
Road traffic accident 26.25 13.25 49 14440 107349 110467461
Contusion 24.77 13.25 77 14412 233284 110341526
Intraocular pressure increased 24.13 13.25 16 14473 10860 110563950
Asthma 22.45 13.25 78 14411 250213 110324597
Psoriasis 21.62 13.25 53 14436 139940 110434870
Vitamin B12 deficiency 20.41 13.25 14 14475 10041 110564769
Visual acuity reduced 20.25 13.25 23 14466 32150 110542660
Dizziness postural 19.90 13.25 16 14473 14593 110560217
Sleep disorder due to general medical condition, insomnia type 18.49 13.25 42 14447 105601 110469209
Cyanosis 18.28 13.25 21 14468 29720 110545090
Skin plaque 17.54 13.25 14 14475 12631 110562179
Nasal congestion 17.12 13.25 39 14450 98243 110476567
Haemolysis 16.92 13.25 15 14474 15624 110559186
Adverse event 16.59 13.25 41 14448 108768 110466042
Lip swelling 16.15 13.25 26 14463 50641 110524169
Vulvovaginal swelling 15.74 13.25 5 14484 608 110574202
Oropharyngeal discomfort 15.55 13.25 12 14477 10315 110564495
Secretion discharge 15.41 13.25 16 14473 20228 110554582
Skin discolouration 15.40 13.25 25 14464 49021 110525789
Autonomic neuropathy 15.32 13.25 7 14482 2293 110572517
Chondritis 15.11 13.25 4 14485 255 110574555
Eye pain 15.01 13.25 25 14464 50074 110524736
Seronegative arthritis 14.98 13.25 13 14476 13164 110561646
Type 2 diabetes mellitus 14.83 13.25 54 14435 177178 110397632
Post inflammatory pigmentation change 14.57 13.25 5 14484 772 110574038
Skin infection 14.01 13.25 16 14473 22493 110552317
Toxicity to various agents 13.86 13.25 109 14380 480446 110094364
Anticholinergic syndrome 13.83 13.25 8 14481 4272 110570538

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:64952 anti-HSV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:77715 nasal decongestant

Related Drugs by ATC class:

C01EB Other cardiac preparations 15 drugs
acadesineacoramidisadenosinecreatinolfosfateibuprofenindomethacinivabradinemavacamtenmeldoniumphosphocreatineranolazineregadenoson show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Skin irritation contraindication 367466007
Cardiovascular event risk contraindication 395112001
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme Ki 4.30 CHEMBL
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 4.20 IUPHAR

External reference:

IDSource
4017533 VUID
N0000145916 NUI
D00098 KEGG_DRUG
464-49-3 SECONDARY_CAS_RN
1298738 RXNORM
C0006809 UMLSCUI
CHEBI:15396 CHEBI
CAM PDB_CHEM_ID
CHEMBL15768 ChEMBL_ID
DB01744 DRUGBANK_ID
D002164 MESH_DESCRIPTOR_UI
2537 PUBCHEM_CID
2422 IUPHAR_LIGAND_ID
DB11288 DRUGBANK_ID
DB14156 DRUGBANK_ID
4343 MMSL
6005 MMSL
111136003 SNOMEDCT_US
412108007 SNOMEDCT_US
46137002 SNOMEDCT_US
4017533 VANDF
C436264 MESH_SUPPLEMENTAL_RECORD_UI
5TJD82A1ET UNII
001385 NDDF
001993 NDDF
005178 NDDF
006104 NDDF
5TJD82A1ET INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AleveX HUMAN OTC DRUG LABEL 2 0280-0049 SPRAY 5.50 mg TOPICAL OTC Monograph Drug 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0050 LOTION 5.50 mg TOPICAL OTC Monograph Drug 15 sections
AleveX HUMAN OTC DRUG LABEL 2 0280-0063 LOTION 5.50 mg TOPICAL OTC Monograph Drug 14 sections
Sarna HUMAN OTC DRUG LABEL 2 0316-0229 LOTION 5 mg TOPICAL OTC Monograph Drug 14 sections
Vaporizing HUMAN OTC DRUG LABEL 1 0363-0055 INHALANT 62 mg RESPIRATORY (INHALATION) OTC Monograph Drug 15 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 7.10 mg TOPICAL OTC monograph not final 14 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 30 mg TOPICAL OTC monograph not final 10 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 3.10 g TOPICAL OTC Monograph Drug 11 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1001 OINTMENT 48 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Chest Rub HUMAN OTC DRUG LABEL 3 0363-1004 OINTMENT 48 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Pain RelievingAnalgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 40 mg TOPICAL OTC Monograph Drug 15 sections
No Touch Application Chest RubWell at Walgreens HUMAN OTC DRUG LABEL 3 0363-3267 STICK 4.80 g TOPICAL OTC monograph final 7 sections
Walgreen Anti Itch HUMAN OTC DRUG LABEL 2 0363-4262 LOTION 0.50 g TOPICAL OTC Monograph Drug 12 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6040 SALVE 1.70 mg TOPICAL OTC monograph not final 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6080 STICK 1.70 mg TOPICAL OTC monograph not final 9 sections
Walgreens Pain Relieving Patch HUMAN OTC DRUG LABEL 3 0363-6716 PATCH 31 mg TOPICAL OTC Monograph Drug 13 sections
Chest Rub HUMAN OTC DRUG LABEL 3 0363-8480 LOTION 4.80 kg TOPICAL OTC monograph final 15 sections
Walgreens Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 0363-9425 GEL 10.80 mg TOPICAL OTC monograph not final 8 sections
Walgreens Childrens Chest Rub HUMAN OTC DRUG LABEL 3 0363-9800 OINTMENT 48 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Lavender Chest Rub HUMAN OTC DRUG LABEL 3 0363-9802 OINTMENT 47 mg TOPICAL OTC Monograph Drug 15 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 1.20 g TOPICAL OTC Monograph Drug 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 3.10 g TOPICAL OTC Monograph Drug 13 sections
HUMCO Camphor Spirit HUMAN OTC DRUG LABEL 1 0395-0467 LIQUID 100 mg TOPICAL OTC Monograph Drug 13 sections
Camphor Spirit HUMAN OTC DRUG LABEL 1 0395-9112 LIQUID 100 mg TOPICAL OTC monograph not final 12 sections
Rugby Anti-Itch HUMAN OTC DRUG LABEL 2 0536-1268 LOTION 0.50 g TOPICAL OTC Monograph Drug 11 sections
ANBESOL COLD SORE THERAPY HUMAN OTC DRUG LABEL 4 0573-0246 OINTMENT 30 mg TOPICAL OTC monograph not final 14 sections
CHAPSTICK MEDICATED HUMAN OTC DRUG LABEL 4 0573-0720 STICK 10 mg TOPICAL OTC Monograph Drug 13 sections
CHAPSTICK CLASSIC MEDICATED HUMAN OTC DRUG LABEL 3 0573-2031 STICK 16 mg TOPICAL OTC Monograph Drug 13 sections
Advil Targeted Relief HUMAN OTC DRUG LABEL 4 0573-6555 CREAM 31 mg TOPICAL OTC Monograph Drug 16 sections