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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory analgesics, phenylbutazone derivatives	4659	68-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: algocalmin metamizole metamizole sodium metamizol metapyrin methampyrone dipyrone dipyrone monohydrate sulpyrine metamizole magnesium metamizole calcium	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Molecular weight: 311.36 Formula: C13H17N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 81.16 ALOGS: -2.09 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

algocalmin
metamizole
metamizole sodium
metamizol
metapyrin
methampyrone
dipyrone
dipyrone monohydrate
sulpyrine
metamizole magnesium
metamizole calcium

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Molecular weight: 311.36
Formula: C13H17N3O4S
CLOGP: -1.20
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 81.16
ALOGS: -2.09
ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P
3	g	R

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	85 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-2.028		Moderate	0.65
caco2-efflux	Caco-2 efflux ratio (BA/AB)	2.009		Moderate	0.65
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.600	10^-6 cm/s	Moderate	0.65
dh-clint	Dog hepatocyte intrinsic clearance	2.871	uL/min/10^6 cells	Moderate	0.65
dppb	Dog plasma protein binding (% unbound)	71.480	%	Moderate	0.65
fcs-ppb	Fetal calf serum protein binding (% unbound)	69.710	%	Moderate	0.65
herg	hERG pIC50	4.142	pIC50	Moderate	0.65
hh-clint	Human hepatocyte intrinsic clearance	1.227	uL/min/10^6 cells	Moderate	0.65
hlm-clint	Human liver microsomal intrinsic clearance	3.184	uL/min/mg protein	Moderate	0.65
hppb	Human plasma protein binding (% unbound)	74.950	%	Moderate	0.65
kinase-safety-class	ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,MAPK7,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK	17
kinase-selectivity-class	GRK2	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	1.028		Moderate	0.65
mh-clint	Mouse hepatocyte intrinsic clearance	2.244		Moderate	0.65
mppb	Mouse plasma protein binding (% unbound)	73.990		Moderate	0.65
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	1.109		Moderate	0.65
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	79.740	%	Moderate	0.65
rh-clint	Rat hepatocyte intrinsic clearance	1.202	uL/min/10^6 cells	Moderate	0.65
rh-fuinc	Rat hepatocyte fraction unbound in incubation	90.520	%	Moderate	0.65
rppb	Rat plasma protein binding (% unbound)	65.530	%	Moderate	0.65
solubility-dd	Solubility at pH 7.4 in DMSO	974.990	uM	Moderate	0.65

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1207.66	12.50	1294	55975	353821	90217357
Product prescribing error	671.38	12.50	344	56925	29801	90541377
Agranulocytosis	579.43	12.50	328	56941	34674	90536504
Anaemia	436.50	12.50	791	56478	352011	90219167
Systemic infection	408.09	12.50	142	57127	4633	90566545
Product monitoring error	353.47	12.50	126	57143	4418	90566760
Haematochezia	350.62	12.50	318	56951	70595	90500583
Labelled drug-drug interaction medication error	258.49	12.50	143	57126	14439	90556739
Fracture	229.95	12.50	154	57115	21922	90549256
Joint swelling	222.74	12.50	28	57241	503272	90067906
Drug ineffective	202.91	12.50	354	56915	1383944	89187234
Systemic lupus erythematosus	201.28	12.50	6	57263	361890	90209288
Polyneuropathy	196.84	12.50	133	57136	19208	90551970
Haematemesis	194.20	12.50	165	57104	33561	90537617
Pemphigus	187.13	12.50	4	57265	326860	90244318
Leukopenia	184.21	12.50	270	56999	100440	90470738
Fall	183.60	12.50	694	56575	481116	90090062
Toxic epidermal necrolysis	182.92	12.50	157	57112	32371	90538807
Synovitis	181.45	12.50	6	57263	329746	90241432
Abdominal discomfort	175.45	12.50	43	57226	477285	90093893
Infusion related reaction	173.10	12.50	28	57241	416752	90154426
Aspirin-exacerbated respiratory disease	150.30	12.50	42	57227	648	90570530
Drug interaction	150.21	12.50	449	56820	276004	90295174
Pancytopenia	148.62	12.50	270	56999	119993	90451185
Pericarditis	148.30	12.50	5	57264	270146	90301032
Stevens-Johnson syndrome	145.61	12.50	132	57137	29244	90541934
Acute kidney injury	145.40	12.50	489	56780	319898	90251280
Treatment failure	144.33	12.50	13	57256	303915	90267263
Abdominal pain lower	140.63	12.50	131	57138	30046	90541132
Renal impairment	138.36	12.50	243	57026	105178	90466000
Swelling	136.97	12.50	47	57222	419011	90152167
Arthropathy	134.50	12.50	33	57236	366209	90204969
Sinusitis	131.80	12.50	28	57241	343060	90228118
Tachypnoea	124.19	12.50	105	57164	21204	90549974
Therapeutic product effect decreased	121.31	12.50	16	57253	277555	90293623
Restlessness	120.28	12.50	130	57139	35590	90535588
Helicobacter infection	118.47	12.50	6	57263	226844	90344334
Product dose omission issue	117.94	12.50	21	57248	291666	90279512
Pallor	116.20	12.50	125	57144	34040	90537138
Folliculitis	114.99	12.50	3	57266	204350	90366828
Nausea	112.27	12.50	1131	56138	1109185	89461993
Alopecia	111.15	12.50	90	57179	494981	90076197
Arrhythmia	108.77	12.50	134	57135	42198	90528980
Lower respiratory tract infection	108.22	12.50	15	57254	250644	90320534
Hypokalaemia	104.80	12.50	246	57023	130870	90440308
Atrial fibrillation	102.81	12.50	247	57022	133364	90437814
Erysipelas	101.17	12.50	66	57203	8986	90562192
Malaise	100.58	12.50	134	57135	585852	89985326
Apathy	98.43	12.50	70	57199	10970	90560208
Dyspnoea	98.01	12.50	916	56353	880039	89691139
Dehydration	95.46	12.50	305	56964	194142	90377036
Abdominal pain	94.29	12.50	496	56773	395225	90175953
Drug hypersensitivity	93.60	12.50	93	57176	463516	90107662
Type 2 diabetes mellitus	93.03	12.50	10	57259	203234	90367944
Tachycardia	92.15	12.50	263	57006	157410	90413768
Maternal exposure during pregnancy	91.88	12.50	57	57212	360006	90211172
Jaundice	91.83	12.50	108	57161	32409	90538769
Product use issue	90.21	12.50	48	57221	329871	90241307
Drug intolerance	90.11	12.50	90	57179	447501	90123677
Upper gastrointestinal haemorrhage	88.76	12.50	90	57179	22886	90548292
Haematoma	88.29	12.50	116	57153	38932	90532246
Vomiting	88.27	12.50	821	56448	787472	89783706
Hyponatraemia	88.23	12.50	233	57036	133305	90437873
Cardiac failure	88.10	12.50	206	57063	109290	90461888
Musculoskeletal stiffness	87.36	12.50	39	57230	296493	90274685
Urosepsis	87.24	12.50	86	57183	21146	90550032
Injury	87.11	12.50	11	57258	197338	90373840
Product administration error	86.92	12.50	95	57174	26328	90544850
Psoriatic arthropathy	86.90	12.50	19	57250	228316	90342862
Drug reaction with eosinophilia and systemic symptoms	86.01	12.50	120	57149	42638	90528540
Rheumatic fever	83.42	12.50	3	57266	153118	90418060
Ascites	81.52	12.50	124	57145	47616	90523562
Nasopharyngitis	79.50	12.50	84	57185	407020	90164158
Irritable bowel syndrome	79.48	12.50	17	57252	207431	90363747
Hypoaesthesia	75.74	12.50	53	57216	314157	90257021
Gamma-glutamyltransferase increased	75.57	12.50	106	57163	37846	90533332
Thrombocytopenia	75.40	12.50	296	56973	208429	90362749
Discomfort	74.85	12.50	40	57229	274295	90296883
Oedema peripheral	74.75	12.50	342	56927	257573	90313605
Dysuria	72.51	12.50	106	57163	39295	90531883
Electrolyte imbalance	72.31	12.50	82	57187	23663	90547515
Arthralgia	71.88	12.50	252	57017	778270	89792908
Ileus	71.69	12.50	69	57200	16477	90554701
Hepatic enzyme increased	70.91	12.50	74	57195	360662	90210516
Rheumatoid arthritis	70.58	12.50	75	57194	362539	90208639
Disturbance in attention	70.25	12.50	115	57154	46994	90524184
Ill-defined disorder	69.11	12.50	16	57253	184875	90386303
Acute hepatic failure	68.85	12.50	78	57191	22483	90548695
Contraindicated product administered	68.34	12.50	61	57208	320078	90251100
Weight increased	67.22	12.50	100	57169	417827	90153351
Off label use	64.74	12.50	420	56849	1101832	89469346
Sinobronchitis	64.36	12.50	22	57247	679	90570499
Gastrointestinal disorder	63.58	12.50	42	57227	256645	90314533
Truncus arteriosus persistent	63.28	12.50	19	57250	382	90570796
Fibromyalgia	62.53	12.50	26	57243	206243	90364935
Peripheral swelling	62.48	12.50	103	57166	413003	90158175
Pleural effusion	61.74	12.50	183	57086	111808	90459370
Syncope	61.38	12.50	204	57065	132459	90438719
Pelvic fracture	61.33	12.50	61	57208	15158	90556020
Listless	60.71	12.50	33	57236	3216	90567962
Hepatic failure	60.62	12.50	98	57171	39630	90531548
Gastritis erosive	60.61	12.50	43	57226	6712	90564466
Headache	60.09	12.50	311	56958	862435	89708743
Drug-induced liver injury	60.05	12.50	158	57111	90160	90481018
Cachexia	59.91	12.50	43	57226	6835	90564343
Reduced facial expression	59.31	12.50	30	57239	2523	90568655
Vascular encephalopathy	58.55	12.50	21	57248	749	90570429
Subileus	57.17	12.50	33	57236	3611	90567567
C-reactive protein abnormal	56.47	12.50	7	57262	127422	90443756
Migraine	56.11	12.50	25	57244	190367	90380811
Spinal pain	55.92	12.50	59	57210	15708	90555470
Gastrointestinal sounds abnormal	55.41	12.50	35	57234	4508	90566670
Congenital cardiovascular anomaly	55.16	12.50	18	57251	480	90570698
Wheezing	54.96	12.50	42	57227	238038	90333140
Liver injury	54.16	12.50	20	57249	170547	90400631
Therapeutic drug monitoring analysis not performed	53.98	12.50	23	57246	1306	90569872
Amnesia	53.24	12.50	4	57265	108501	90462677
Osteochondrosis	52.83	12.50	25	57244	1818	90569360
Gait inability	52.16	12.50	14	57255	146442	90424736
Rash	52.07	12.50	293	56976	795807	89775371
Intentional product use issue	51.69	12.50	37	57232	216855	90354323
Joint range of motion decreased	50.17	12.50	12	57257	135631	90435547
Hypersensitivity	49.80	12.50	136	57133	454541	90116637
Completed suicide	49.56	12.50	15	57254	145043	90426135
Psoriasis	49.20	12.50	16	57253	147738	90423440
Malignant neoplasm progression	49.13	12.50	164	57105	106706	90464472
Therapy non-responder	48.81	12.50	13	57256	136691	90434487
Mucosal haemorrhage	48.80	12.50	22	57247	1431	90569747
Adverse event	48.42	12.50	8	57261	117410	90453768
Faecaloma	48.04	12.50	45	57224	10386	90560792
Injection site pain	47.84	12.50	25	57244	173674	90397504
Sepsis	47.36	12.50	232	57037	179582	90391596
Hyperaesthesia	47.06	12.50	45	57224	10657	90560521
Bursitis	46.11	12.50	13	57256	131641	90439537
Impaired healing	46.03	12.50	48	57221	234151	90337027
Respiratory alkalosis	45.68	12.50	28	57241	3420	90567758
Bradycardia	45.25	12.50	136	57133	83711	90487467
Insomnia	45.14	12.50	89	57180	333385	90237793
Spontaneous haemorrhage	44.71	12.50	17	57252	716	90570462
Circulatory collapse	44.38	12.50	66	57203	24838	90546340
Nasal disorder	44.30	12.50	27	57242	3265	90567913
Leukocytosis	43.99	12.50	74	57195	30916	90540262
Mucosal erosion	43.80	12.50	22	57247	1823	90569355
Product use in unapproved indication	43.59	12.50	92	57177	336144	90235034
Cardiac septal defect	43.58	12.50	17	57252	768	90570410
Gallbladder polyp	43.44	12.50	18	57251	953	90570225
Haemorrhagic erosive gastritis	43.25	12.50	15	57254	484	90570694
Blood cholesterol increased	42.75	12.50	41	57228	207971	90363207
Gastrointestinal infection	42.36	12.50	43	57226	10947	90560231
Facet joint syndrome	42.17	12.50	6	57263	98383	90472795
Hepatorenal failure	41.92	12.50	16	57253	681	90570497
Constipation	40.75	12.50	310	56959	280085	90291093
Concomitant disease aggravated	40.67	12.50	43	57226	11475	90559703
Neutropenia	40.51	12.50	262	57007	224642	90346536
Abdominal pain upper	40.36	12.50	353	56916	332321	90238857
Illness	40.27	12.50	3	57266	81966	90489212
Therapeutic product effect incomplete	40.10	12.50	38	57231	193858	90377320
Bone abscess	40.07	12.50	14	57255	462	90570716
Hepatitis cholestatic	39.56	12.50	37	57232	8524	90562654
Staphylococcal abscess	39.44	12.50	16	57253	802	90570376
Urogenital haemorrhage	39.34	12.50	12	57257	255	90570923
Depressed level of consciousness	39.22	12.50	118	57151	72666	90498512
Pyrexia	39.19	12.50	610	56659	659875	89911303
Blister	39.06	12.50	63	57206	254935	90316243
Hospitalisation	39.05	12.50	16	57253	128084	90443094
Hepatitis toxic	38.81	12.50	26	57243	3699	90567479
Stenosis	38.47	12.50	21	57248	2063	90569115
Dyspnoea exertional	37.83	12.50	116	57153	72172	90499006
Contusion	37.60	12.50	63	57206	251153	90320025
Gastritis	37.40	12.50	82	57187	41671	90529507
Cross sensitivity reaction	37.34	12.50	23	57246	2834	90568344
Hepatitis acute	37.30	12.50	40	57229	10847	90560331
Urinary retention	37.12	12.50	77	57192	37667	90533511
Prescription drug used without a prescription	37.03	12.50	24	57245	3231	90567947
Road traffic accident	37.00	12.50	11	57258	107615	90463563
Pulmonary fibrosis	36.93	12.50	11	57258	107492	90463686
Head discomfort	36.11	12.50	48	57221	16285	90554893
Somatic symptom disorder	35.81	12.50	24	57245	3417	90567761
Prerenal failure	35.45	12.50	20	57249	2095	90569083
Intentional overdose	35.42	12.50	135	57134	93699	90477479
Gastroenteritis	35.27	12.50	65	57204	29164	90542014
Therapeutic response decreased	35.08	12.50	7	57262	89722	90481456
Dizziness	34.84	12.50	544	56725	588740	89982438
Autoimmune disorder	34.53	12.50	4	57265	76740	90494438
Chromaturia	34.40	12.50	51	57218	19136	90552042
Somnolence	34.29	12.50	238	57031	208846	90362332
Immobile	34.18	12.50	30	57239	6368	90564810
Angina pectoris	34.05	12.50	76	57193	39084	90532094
Electrocardiogram abnormal	33.82	12.50	37	57232	10261	90560917
Bicytopenia	33.82	12.50	24	57245	3747	90567431
Transaminases increased	33.26	12.50	73	57196	37119	90534059
Facial nerve disorder	33.23	12.50	13	57256	592	90570586
Conjunctivitis	33	12.50	60	57209	26646	90544532
Mobility decreased	32.99	12.50	68	57201	250666	90320512
Dementia	32.57	12.50	56	57213	23805	90547373
Peripheral nerve lesion	32.51	12.50	12	57257	465	90570713
Muscle tone disorder	32.02	12.50	9	57260	142	90571036
Vertigo	31.96	12.50	107	57162	69704	90501474
Central pain syndrome	31.94	12.50	13	57256	657	90570521
Humerus fracture	31.86	12.50	35	57234	9750	90561428
Nasal congestion	31.60	12.50	7	57262	83407	90487771
Heart disease congenital	31.51	12.50	17	57252	1632	90569546
Knee arthroplasty	31.47	12.50	7	57262	83175	90488003
Disorientation	31.19	12.50	79	57190	44035	90527143
Oliguria	31.18	12.50	36	57233	10588	90560590
Pneumonitis	31.13	12.50	79	57190	44091	90527087
Paresis	30.84	12.50	20	57249	2694	90568484
Injection site erythema	30.51	12.50	12	57257	98490	90472688
Inappropriate schedule of product administration	30.28	12.50	30	57239	149903	90421275
Spinal osteoarthritis	30.26	12.50	48	57221	19100	90552078
Flank pain	30.12	12.50	48	57221	19174	90552004
Suspected product quality issue	29.93	12.50	11	57258	421	90570757
Foreign body	29.88	12.50	19	57250	2475	90568703
Wound infection	29.76	12.50	15	57254	106387	90464791
Hepatic cyst	29.61	12.50	28	57241	6540	90564638
Type I hypersensitivity	29.54	12.50	23	57246	4132	90567046
Normochromic normocytic anaemia	29.43	12.50	25	57244	5077	90566101
Exposure during pregnancy	29.43	12.50	67	57202	238343	90332835
Inflammation	29.38	12.50	42	57227	178550	90392628
Cholestatic liver injury	29.15	12.50	22	57247	3775	90567403
Paranasal sinus inflammation	29.11	12.50	12	57257	627	90570551
Adverse drug reaction	29.00	12.50	19	57250	116682	90454496
Multiple organ dysfunction syndrome	28.89	12.50	102	57167	68234	90502944
Arthritis	28.88	12.50	38	57231	167277	90403901
Febrile neutropenia	28.82	12.50	185	57084	158164	90413014
Hypercholesterolaemia	28.55	12.50	14	57255	100878	90470300
Pregnancy	28.51	12.50	3	57266	62044	90509134
Parapharyngeal space infection	28.38	12.50	5	57264	5	90571173
Nail avulsion	28.28	12.50	10	57259	342	90570836
Chills	27.70	12.50	160	57109	131821	90439357
Sensory disturbance	27.68	12.50	41	57228	15372	90555806
Catheter site inflammation	27.49	12.50	13	57256	944	90570234
Cardiac failure congestive	27.47	12.50	14	57255	98680	90472498
Cholecystitis	27.32	12.50	43	57226	16997	90554181
Injection site reaction	27.26	12.50	12	57257	92068	90479110
Antineutrophil cytoplasmic antibody positive	27.21	12.50	12	57257	741	90570437
Coombs negative haemolytic anaemia	27.21	12.50	10	57259	383	90570795
Gastric ulcer	26.99	12.50	56	57213	27392	90543786
Acute generalised exanthematous pustulosis	26.87	12.50	38	57231	13665	90557513
Diverticulum intestinal	26.87	12.50	31	57238	9111	90562067
Tumour pain	26.74	12.50	16	57253	1871	90569307
Nail toxicity	26.60	12.50	10	57259	408	90570770
Painful respiration	26.59	12.50	19	57250	2999	90568179
Necrotising fasciitis	26.56	12.50	21	57248	3859	90567319
Pneumobilia	26.55	12.50	8	57261	163	90571015
Haematuria	26.21	12.50	64	57205	34873	90536305
Hyperglycaemia	25.93	12.50	81	57188	50889	90520289
Feeling abnormal	25.89	12.50	41	57228	167194	90403984
Face oedema	25.84	12.50	50	57219	23268	90547910
Paraesthesia	25.81	12.50	77	57192	250249	90320929
Oesophagitis	25.56	12.50	42	57227	17207	90553971
Dysphagia	25.47	12.50	139	57130	112139	90459039
Pseudarthrosis	25.46	12.50	10	57259	460	90570718
Post-traumatic pain	25.10	12.50	10	57259	478	90570700
Heart rate increased	24.68	12.50	21	57248	112881	90458297
Blood pressure increased	24.68	12.50	55	57214	197162	90374016
Thirst decreased	24.60	12.50	9	57260	340	90570838
Anaphylactic reaction	24.52	12.50	115	57154	87409	90483769
Hypertensive emergency	24.37	12.50	16	57253	2201	90568977
Duodenal ulcer	24.15	12.50	30	57239	9522	90561656
Psychotic symptom	24.12	12.50	16	57253	2240	90568938
Injection site pruritus	23.74	12.50	3	57266	53831	90517347
Device stimulation issue	23.68	12.50	6	57263	62	90571116
Patent ductus arteriosus	23.56	12.50	21	57248	4548	90566630
Medication error	23.55	12.50	111	57158	84541	90486637
Upper respiratory tract infection	23.34	12.50	28	57241	128290	90442888
Glomerular filtration rate abnormal	23.31	12.50	13	57256	1332	90569846
Fluid intake reduced	23.25	12.50	20	57249	4132	90567046
Thirst	23.24	12.50	39	57230	16256	90554922
Helicobacter gastritis	23.02	12.50	14	57255	1686	90569492
Petechiae	22.89	12.50	38	57231	15703	90555475
Immune-mediated enterocolitis	22.83	12.50	21	57248	4736	90566442
Disease progression	22.76	12.50	40	57229	156575	90414603
Autoimmune thyroiditis	22.60	12.50	23	57246	5870	90565308
Localised infection	22.59	12.50	59	57210	33503	90537675
Lethargy	22.54	12.50	6	57263	63133	90508045
Nocturia	22.46	12.50	30	57239	10225	90560953
Fluid retention	22.36	12.50	14	57255	88077	90483101
Gastric mucosa erythema	22.30	12.50	9	57260	445	90570733
Nail disorder	22.28	12.50	5	57264	59062	90512116
Gastritis haemorrhagic	22.28	12.50	14	57255	1786	90569392
Coronavirus test positive	22.21	12.50	11	57258	884	90570294
Hypertensive crisis	22.03	12.50	40	57229	17744	90553434
Blood creatinine increased	21.98	12.50	124	57145	101262	90469916
Abortion induced	21.89	12.50	32	57237	11856	90559322
Immune-mediated hypothyroidism	21.53	12.50	13	57256	1545	90569633
Urticaria	21.52	12.50	113	57156	312621	90258557
Loss of personal independence in daily activities	21.42	12.50	33	57236	136072	90435106
Food interaction	21.32	12.50	12	57257	1252	90569926
Heart rate decreased	21.28	12.50	4	57265	53501	90517677
Asthma	21.19	12.50	80	57189	242080	90329098
Confusional state	21.12	12.50	150	57119	386055	90185123
Metastatic malignant melanoma	21.04	12.50	13	57256	1611	90569567
Adjustment disorder with depressed mood	21.02	12.50	5	57264	56748	90514430
Dermatitis bullous	20.81	12.50	29	57240	10287	90560891
Neuropathy peripheral	20.81	12.50	34	57235	136936	90434242
Acute abdomen	20.75	12.50	13	57256	1650	90569528
Anaemia folate deficiency	20.70	12.50	9	57260	537	90570641
Ventricular septal defect	20.55	12.50	21	57248	5386	90565792
Affective disorder	20.54	12.50	25	57244	7768	90563410
Junctional ectopic tachycardia	20.54	12.50	7	57262	214	90570964
Pain in jaw	20.39	12.50	3	57266	47982	90523196
Suicide attempt	20.34	12.50	98	57171	75301	90495877
Prescribed overdose	20.33	12.50	19	57250	97606	90473572
Immune-mediated hepatitis	20.29	12.50	16	57253	2928	90568250
Lung disorder	20.26	12.50	40	57229	149843	90421335
Allergic sinusitis	20.24	12.50	14	57255	2099	90569079
VIIIth nerve injury	20.19	12.50	4	57265	11	90571167
Diverticulum intestinal haemorrhagic	20.07	12.50	13	57256	1748	90569430
Hypotonia	19.95	12.50	30	57239	11396	90559782
No adverse event	19.90	12.50	9	57260	67973	90503205
Acute respiratory failure	19.83	12.50	66	57203	42852	90528326
Lumbar vertebral fracture	19.78	12.50	24	57245	7434	90563744
Peritoneal perforation	19.74	12.50	6	57263	126	90571052
Lividity	19.72	12.50	8	57261	401	90570777
Hyperaemia	19.60	12.50	15	57254	2627	90568551
Peripheral arterial occlusive disease	19.51	12.50	19	57250	4602	90566576
Anaemia of malignant disease	19.41	12.50	9	57260	625	90570553
Medication overuse headache	19.40	12.50	12	57257	1489	90569689
Depression	19.37	12.50	111	57158	300490	90270688
Mixed liver injury	19.36	12.50	24	57245	7599	90563579
Joint stiffness	18.99	12.50	13	57256	78029	90493149
Aortic valve stenosis	18.97	12.50	18	57251	4222	90566956
Septic shock	18.96	12.50	104	57165	84056	90487122
Defaecation disorder	18.94	12.50	10	57259	919	90570259
Haemangioma of bone	18.90	12.50	7	57262	274	90570904
Genital erosion	18.76	12.50	8	57261	455	90570723
Cerebral haemorrhage	18.62	12.50	56	57213	34466	90536712
Flatulence	18.57	12.50	63	57206	41304	90529874
Red blood cell sedimentation rate increased	18.50	12.50	15	57254	82580	90488598
Intervertebral disc protrusion	18.50	12.50	48	57221	27148	90544030
Sensory level abnormal	18.46	12.50	6	57263	158	90571020
Lymphoedema	18.41	12.50	32	57237	13721	90557457
Dyslalia	18.34	12.50	9	57260	709	90570469
Left ventricular hypertrophy	18.33	12.50	21	57248	6123	90565055
Confusional arousal	18.25	12.50	7	57262	302	90570876
Oesophageal candidiasis	18.15	12.50	22	57247	6807	90564371
Facial paresis	18.07	12.50	17	57252	3946	90567232
Cardiac failure chronic	18.05	12.50	20	57249	5626	90565552
Rhonchi	18.02	12.50	15	57254	2963	90568215
Ileus paralytic	17.98	12.50	19	57250	5066	90566112
Mesenteric arterial occlusion	17.84	12.50	6	57263	176	90571002
Suspected product contamination	17.72	12.50	5	57264	80	90571098
Lordosis	17.70	12.50	7	57262	328	90570850
Dysplasia	17.65	12.50	11	57258	1383	90569795
Foramen magnum stenosis	17.62	12.50	6	57263	183	90570995
Hypertransaminasaemia	17.61	12.50	34	57235	15791	90555387
Autoimmune colitis	17.56	12.50	9	57260	778	90570400
Pulmonary vein occlusion	17.12	12.50	5	57264	91	90571087
Necrosis	17.09	12.50	21	57248	6589	90564589
Pancreatic failure	16.97	12.50	11	57258	1481	90569697
Chronic gastritis	16.96	12.50	16	57253	3725	90567453
Adrenal calcification	16.93	12.50	4	57265	30	90571148
Tracheal atresia	16.81	12.50	4	57265	31	90571147
Lupus-like syndrome	16.77	12.50	5	57264	48841	90522337
Hyperkinesia	16.72	12.50	12	57257	1907	90569271
Memory impairment	16.71	12.50	66	57203	197178	90374000
Surgery	16.53	12.50	4	57265	44883	90526295
Faeces pale	16.48	12.50	12	57257	1951	90569227
Aortic valve sclerosis	16.48	12.50	10	57259	1200	90569978
Internal haemorrhage	16.47	12.50	20	57249	6200	90564978
Unevaluable event	16.47	12.50	7	57262	54841	90516337
Acute myocardial infarction	16.43	12.50	54	57215	34836	90536342
Vasculitis	16.42	12.50	41	57228	22652	90548526
Oedema	16.35	12.50	68	57201	200227	90370951
Iron deficiency anaemia	16.34	12.50	42	57227	23620	90547558
Disability	16.30	12.50	3	57266	40742	90530436
Gastroduodenal ulcer	16.30	12.50	7	57262	405	90570773
Peripheral circulatory failure	16.24	12.50	11	57258	1593	90569585
Myosclerosis	16.20	12.50	6	57263	235	90570943
Reactive gastropathy	16.12	12.50	8	57261	646	90570532
Intraductal proliferative breast lesion	16.10	12.50	15	57254	3438	90567740
Brain contusion	15.99	12.50	8	57261	657	90570521
Musculoskeletal pain	15.95	12.50	172	57097	171079	90400099
Cardiac murmur functional	15.90	12.50	4	57265	40	90571138
Lymphocytosis	15.90	12.50	14	57255	2983	90568195
Hepatosplenomegaly	15.85	12.50	14	57255	2995	90568183
Urinary tract infection enterococcal	15.83	12.50	14	57255	3002	90568176
Deficiency of bile secretion	15.81	12.50	4	57265	41	90571137
Hyperkalaemia	15.80	12.50	82	57187	64882	90506296
Hypotension	15.75	12.50	291	56978	325106	90246072
Systemic inflammatory response syndrome	15.73	12.50	20	57249	6496	90564682
Urogenital infection bacterial	15.73	12.50	4	57265	42	90571136
Status epilepticus	15.70	12.50	36	57233	18838	90552340
Bile duct stone	15.70	12.50	16	57253	4091	90567087
Jugular vein thrombosis	15.64	12.50	15	57254	3566	90567612
Exostosis	15.61	12.50	7	57262	53127	90518051
Cellulitis	15.50	12.50	21	57248	91316	90479862
Fixed eruption	15.49	12.50	11	57258	1719	90569459
Gastric ulcer perforation	15.40	12.50	10	57259	1350	90569828
Allodynia	15.34	12.50	9	57260	1015	90570163
Femoral neck fracture	15.28	12.50	25	57244	10208	90560970
Hip deformity	15.26	12.50	6	57263	277	90570901
Folate deficiency	15.24	12.50	14	57255	3151	90568027
Mucosal dryness	15.24	12.50	14	57255	3153	90568025
Feeling cold	15.24	12.50	45	57224	27420	90543758
Pericardial drainage	15.12	12.50	6	57263	284	90570894
Thalamus haemorrhage	15.05	12.50	8	57261	745	90570433
Anxiety disorder	14.99	12.50	17	57252	4905	90566273
Necrolytic migratory erythema	14.95	12.50	3	57266	9	90571169
Delirium	14.92	12.50	115	57154	104244	90466934
Vertebral lesion	14.87	12.50	8	57261	764	90570414
Stomatitis	14.85	12.50	107	57162	274591	90296587
Stoma site inflammation	14.85	12.50	8	57261	766	90570412
Bulimia nervosa	14.82	12.50	7	57262	507	90570671
Reticulocyte count increased	14.78	12.50	9	57260	1086	90570092
Macular degeneration	14.76	12.50	3	57266	37967	90533211
Melaena	14.75	12.50	52	57217	34745	90536433
Bone marrow oedema	14.74	12.50	10	57259	1453	90569725
Anti-saccharomyces cerevisiae antibody test positive	14.67	12.50	4	57265	56	90571122
Myocardial infarction	14.56	12.50	28	57241	105944	90465234
Shock haemorrhagic	14.48	12.50	27	57242	12218	90558960
Dyschezia	14.44	12.50	13	57256	2852	90568326
Pulmonary embolism	14.40	12.50	136	57133	130684	90440494
Merycism	14.35	12.50	6	57263	325	90570853
Kyphosis	14.27	12.50	13	57256	2895	90568283
Lymphadenopathy	14.20	12.50	62	57207	45713	90525465
SARS-CoV-2 antibody test negative	14.14	12.50	6	57263	337	90570841
Wound	14.07	12.50	123	57146	302857	90268321
Hyperresponsive to stimuli	14.06	12.50	4	57265	66	90571112
Breast neoplasm	14.04	12.50	10	57259	1570	90569608
Aspartate aminotransferase increased	13.93	12.50	112	57157	102825	90468353
Rash maculo-papular	13.91	12.50	57	57212	40876	90530302
Varicose vein	13.90	12.50	20	57249	7307	90563871
Pyelonephritis	13.86	12.50	37	57232	21279	90549899
Drug ineffective for unapproved indication	13.84	12.50	13	57256	66631	90504547
Substance dependence	13.82	12.50	5	57264	183	90570995
Normochromic anaemia	13.80	12.50	6	57263	358	90570820
Hyperventilation	13.70	12.50	19	57250	6709	90564469
Osteoporosis postmenopausal	13.66	12.50	6	57263	367	90570811
Metastatic gastric cancer	13.64	12.50	5	57264	190	90570988
Immune-mediated hyperthyroidism	13.61	12.50	6	57263	370	90570808
Thrombophlebitis	13.57	12.50	16	57253	4812	90566366
Iliotibial band syndrome	13.55	12.50	6	57263	374	90570804
Pulmonary atypical adenomatous hyperplasia	13.54	12.50	4	57265	76	90571102
Gastrointestinal tract adenoma	13.51	12.50	6	57263	377	90570801
Affect lability	13.45	12.50	33	57236	18030	90553148
Post procedural sepsis	13.43	12.50	6	57263	382	90570796
Respiratory tract infection	13.30	12.50	73	57196	59005	90512173
Nutritional condition abnormal	13.29	12.50	8	57261	946	90570232
Myoclonus	13.21	12.50	34	57235	19134	90552044
CD8 lymphocytes decreased	13.19	12.50	5	57264	209	90570969
Urinary tract infection bacterial	13.18	12.50	18	57251	6267	90564911
Bladder disorder	13.05	12.50	24	57245	10748	90560430
Orthostatic intolerance	13.04	12.50	9	57260	1345	90569833
Anticholinergic syndrome	12.95	12.50	12	57257	2731	90568447
Sciatica	12.90	12.50	28	57241	101354	90469824
Hypoalbuminaemia	12.87	12.50	30	57239	15867	90555311
Decreased appetite	12.82	12.50	320	56949	376220	90194958
Cardiomyopathy alcoholic	12.76	12.50	3	57266	22	90571156
Breast cancer metastatic	12.74	12.50	29	57240	15103	90556075
Epidermolysis	12.69	12.50	7	57262	702	90570476
Disease recurrence	12.66	12.50	4	57265	37649	90533529
Portal hypertensive gastropathy	12.60	12.50	8	57261	1039	90570139

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1571.81	13.34	1372	50930	149874	42419159
Product prescribing error	366.13	13.34	283	52019	25829	42543204
Systemic infection	286.48	13.34	136	52166	5069	42563964
Anaemia	230.73	13.34	811	51491	279467	42289566
Appendicolith	229.23	13.34	164	52138	13292	42555741
Product monitoring error	223.51	13.34	109	52193	4314	42564719
Agranulocytosis	192.73	13.34	212	52090	30400	42538633
Appendicitis	185.13	13.34	173	52129	20440	42548593
Drug ineffective	177.45	13.34	315	51987	629882	41939151
Blood phosphorus increased	163.06	13.34	130	52172	12395	42556638
Death	139.22	13.34	228	52074	470957	42098076
Abdominal pain	130.34	13.34	520	51782	189951	42379082
Haematochezia	128.02	13.34	245	52057	58191	42510842
Ventricular fibrillation	125	13.34	169	52133	29954	42539079
Constipation	122.38	13.34	457	51845	161834	42407199
Myasthenia gravis	121.55	13.34	123	52179	16014	42553019
Analgesic therapy	121.52	13.34	84	52218	6440	42562593
Cardiogenic shock	120.00	13.34	181	52121	35459	42533574
Blood uric acid increased	116.18	13.34	118	52184	15429	42553604
Hyperphosphataemia	114.56	13.34	108	52194	12896	42556137
Hyponatraemia	109.80	13.34	323	51979	101139	42467894
Drug therapy	106.89	13.34	77	52225	6303	42562730
Vomiting	103.48	13.34	658	51644	289065	42279968
Ascites	101.96	13.34	219	52083	56459	42512574
Sleep disorder therapy	101.56	13.34	77	52225	6817	42562216
Stress	101.31	13.34	189	52113	44023	42525010
Malaise	97.44	13.34	71	52231	212085	42356948
Iron deficiency	92.00	13.34	89	52213	10972	42558061
Labelled drug-drug interaction medication error	91.32	13.34	104	52198	15478	42553555
Musculoskeletal pain	89.84	13.34	153	52149	33187	42535846
Abdominal distension	88.97	13.34	240	52062	71495	42497538
Completed suicide	86.30	13.34	9	52293	96456	42472577
Multiple organ dysfunction syndrome	84.83	13.34	287	52015	96748	42472285
Hypophosphataemia	84.59	13.34	116	52186	20829	42548204
Incorrect route of product administration	84.03	13.34	125	52177	24180	42544853
Nausea	83.57	13.34	797	51505	396002	42173031
Bacterial infection	83.26	13.34	134	52168	27745	42541288
Neuralgia	81.74	13.34	127	52175	25520	42543513
Leukopenia	79.91	13.34	237	52065	74509	42494524
Cardiac failure congestive	79.18	13.34	7	52295	85595	42483438
Dry mouth	75.07	13.34	157	52145	39722	42529311
Polyneuropathy	71.84	13.34	101	52201	18560	42550473
Antacid therapy	70.18	13.34	53	52249	4664	42564369
Toxicity to various agents	67.29	13.34	111	52191	229025	42340008
Tachypnoea	67.26	13.34	106	52196	21556	42547477
Product dose omission issue	66.58	13.34	55	52247	154310	42414723
Anticoagulant therapy	65.36	13.34	50	52252	4485	42564548
Abdominal pain upper	64.97	13.34	236	52066	82373	42486660
Dyspnoea	62.92	13.34	823	51479	441798	42127235
Blood cholesterol increased	62.10	13.34	115	52187	26626	42542407
Pallor	58.23	13.34	117	52185	28769	42540264
Sleep disorder	57.69	13.34	159	52143	47936	42521097
Tachycardia	54.42	13.34	257	52045	100830	42468203
Micturition disorder	53.54	13.34	35	52267	2445	42566588
Hospitalisation	52.94	13.34	13	52289	74317	42494716
Oedema peripheral	52.12	13.34	315	51987	135761	42433272
Osteochondrosis	51.54	13.34	28	52274	1390	42567643
Restlessness	51.40	13.34	112	52190	29137	42539896
Blood pressure increased	50.92	13.34	31	52271	101897	42467136
Paresis	50.91	13.34	34	52268	2462	42566571
Ulcer	49.04	13.34	79	52223	16362	42552671
Platelet count decreased	48.72	13.34	59	52243	138522	42430511
Treatment failure	48.59	13.34	9	52293	62615	42506418
Neuropathy peripheral	48.12	13.34	33	52269	101820	42467213
Acute abdomen	47.06	13.34	30	52272	2007	42567026
Activated partial thromboplastin time prolonged	46.87	13.34	76	52226	15827	42553206
Interstitial lung disease	46.51	13.34	19	52283	78443	42490590
Feeling abnormal	46.33	13.34	14	52288	69772	42499261
Chronic obstructive pulmonary disease	46.01	13.34	176	52126	62938	42506095
Lethargy	45.71	13.34	3	52299	46887	42522146
Joint swelling	44.52	13.34	14	52288	68008	42501025
Fracture	43.99	13.34	52	52250	8051	42560982
Cardiovascular disorder	43.72	13.34	67	52235	13298	42555735
Disease progression	43.62	13.34	68	52234	143588	42425445
Gamma-glutamyltransferase increased	43.59	13.34	112	52190	32385	42536648
Mucosal haemorrhage	42.94	13.34	27	52275	1763	42567270
Infusion related reaction	42.60	13.34	11	52291	60795	42508238
Blood calcium increased	42.21	13.34	52	52250	8402	42560631
Sepsis	41.07	13.34	399	51903	198935	42370098
Dyschezia	40.53	13.34	26	52276	1758	42567275
Condition aggravated	40.37	13.34	493	51809	260261	42308772
Myocardial infarction	40.28	13.34	56	52246	123953	42445080
Electrolyte imbalance	40.27	13.34	74	52228	17027	42552006
Bronchopulmonary aspergillosis allergic	40.13	13.34	38	52264	4560	42564473
Cardiac arrest	40.07	13.34	45	52257	109275	42459758
Platelet dysfunction	39.90	13.34	15	52287	308	42568725
End stage renal disease	39.43	13.34	72	52230	16486	42552547
Congenital hiatus hernia	39.24	13.34	43	52259	6131	42562902
Electrocardiogram abnormal	39.18	13.34	55	52247	10090	42558943
Erysipelas	38.55	13.34	43	52259	6253	42562780
Bacteroides infection	38.33	13.34	29	52273	2558	42566475
Respiratory tract haemorrhage	38.26	13.34	23	52279	1386	42567647
Polyneuropathy in malignant disease	37.69	13.34	15	52287	361	42568672
Therapeutic drug monitoring analysis not performed	37.60	13.34	17	52285	565	42568468
Diverticulitis intestinal perforated	37.49	13.34	14	52288	282	42568751
Haematemesis	37.36	13.34	101	52201	30098	42538935
Pyrexia	35.42	13.34	679	51623	393363	42175670
Hyperventilation	35.08	13.34	30	52272	3152	42565881
Therapy non-responder	34.89	13.34	11	52291	53348	42515685
Prostatic pain	34.87	13.34	14	52288	345	42568688
Transaminases increased	34.85	13.34	104	52198	32781	42536252
Troponin increased	34.64	13.34	74	52228	18988	42550045
Urosepsis	34.12	13.34	64	52238	14956	42554077
Neuromuscular block prolonged	33.52	13.34	16	52286	603	42568430
Diabetes mellitus	33.21	13.34	154	52148	59933	42509100
Cold sweat	33.19	13.34	54	52248	11276	42557757
Cachexia	32.89	13.34	45	52257	8059	42560974
Drug reaction with eosinophilia and systemic symptoms	32.88	13.34	120	52182	41955	42527078
Hepatic cyst	32.51	13.34	28	52274	2970	42566063
Total lung capacity decreased	32.11	13.34	30	52272	3540	42565493
Aortic stenosis	31.70	13.34	46	52256	8699	42560334
Micturition urgency	31.24	13.34	54	52248	11844	42557189
Heart rate decreased	31.18	13.34	4	52298	36528	42532505
Labelled drug-drug interaction issue	31.10	13.34	22	52280	1749	42567284
Abdominal discomfort	30.97	13.34	28	52274	75227	42493806
Lung opacity	30.93	13.34	37	52265	5800	42563233
Drug-induced liver injury	30.62	13.34	110	52192	38163	42530870
Somnolence	30.29	13.34	285	52017	140820	42428213
Gout	29.99	13.34	89	52213	27966	42541067
Impaired healing	29.62	13.34	65	52237	16988	42552045
C-reactive protein increased	29.50	13.34	155	52147	63405	42505628
Blood test abnormal	29.33	13.34	55	52247	12851	42556182
Drug abuse	28.66	13.34	53	52249	104718	42464315
Drug resistance	28.63	13.34	4	52298	34244	42534789
Wound	28.33	13.34	64	52238	17053	42551980
Loss of personal independence in daily activities	28.03	13.34	13	52289	49803	42519230
Toxic epidermal necrolysis	27.78	13.34	84	52218	26666	42542367
Therapeutic product effect decreased	27.58	13.34	7	52295	39143	42529890
Rash	27.49	13.34	213	52089	276741	42292292
Negative pressure pulmonary oedema	27.43	13.34	14	52288	611	42568422
Blood pressure measurement	27.32	13.34	10	52292	190	42568843
Flushing	27.31	13.34	6	52296	37022	42532011
Accessory spleen	26.80	13.34	9	52293	131	42568902
Unevaluable event	26.44	13.34	5	52297	34283	42534750
Rectal haemorrhage	26.32	13.34	14	52288	49592	42519441
Leptotrichia infection	26.11	13.34	8	52294	85	42568948
Disturbance in attention	25.76	13.34	88	52214	29778	42539255
Internal fixation of fracture	25.46	13.34	8	52294	93	42568940
Product administration error	25.40	13.34	64	52238	18279	42550754
Osteoma	25.39	13.34	8	52294	94	42568939
Pleuritic pain	25.32	13.34	37	52265	7040	42561993
Hypertensive crisis	25.09	13.34	45	52257	10161	42558872
Polycystic liver disease	25.01	13.34	8	52294	99	42568934
Lack of application site rotation	24.73	13.34	7	52295	55	42568978
Cardiac disorder	24.26	13.34	15	52287	48917	42520116
Dehiscence	24.16	13.34	13	52289	633	42568400
Mononeuropathy	23.95	13.34	10	52292	273	42568760
Splenic necrosis	23.79	13.34	8	52294	117	42568916
Gastrointestinal adenocarcinoma	23.70	13.34	7	52295	65	42568968
Arthropathy	23.51	13.34	4	52298	29593	42539440
Muscle spasms	23.11	13.34	44	52258	86000	42483033
Off label use	22.88	13.34	603	51699	637732	41931301
Deep vein thrombosis	22.80	13.34	37	52265	76920	42492113
Splenic cyst	22.79	13.34	8	52294	134	42568899
Hyperlipidaemia	22.75	13.34	68	52234	21448	42547585
Allodynia	22.55	13.34	15	52287	1079	42567954
Febrile infection	22.48	13.34	22	52280	2749	42566284
Orthostatic hypotension	22.45	13.34	5	52297	30565	42538468
Haemoglobin urine present	22.36	13.34	8	52294	142	42568891
Fall	22.34	13.34	408	51894	234112	42334921
Spinal osteoarthritis	22.26	13.34	39	52263	8647	42560386
Swelling	22.22	13.34	129	52173	54756	42514277
Activated partial thromboplastin time abnormal	22.00	13.34	8	52294	149	42568884
Coma	21.95	13.34	20	52282	53534	42515499
Gastritis	21.93	13.34	72	52230	23875	42545158
Cellulitis	21.85	13.34	26	52276	61559	42507474
Intentional product use issue	21.79	13.34	34	52268	71799	42497234
Rhabdomyolysis	21.75	13.34	39	52263	77980	42491053
Suspected product quality issue	21.72	13.34	9	52293	241	42568792
Cerebrovascular accident	21.71	13.34	55	52247	97105	42471928
Cardio-respiratory arrest	21.63	13.34	24	52278	58612	42510421
Hepatic function abnormal	21.44	13.34	19	52283	51548	42517485
Psychotic disorder	21.00	13.34	5	52297	29203	42539830
Implant site inflammation	20.78	13.34	7	52295	103	42568930
Iris adhesions	20.77	13.34	9	52293	270	42568763
No adverse event	20.72	13.34	11	52291	39010	42530023
Urinary sediment present	20.64	13.34	9	52293	274	42568759
Illness	20.63	13.34	3	52299	24927	42544106
Medication error	20.60	13.34	88	52214	33066	42535967
Drug ineffective for unapproved indication	20.44	13.34	16	52286	46147	42522886
Reflux nephropathy	20.30	13.34	5	52297	21	42569012
Anxiety	20.18	13.34	76	52226	118484	42450549
Respiratory arrest	20.18	13.34	5	52297	28419	42540614
Platelet function test abnormal	20.07	13.34	7	52295	115	42568918
Suspected product contamination	19.82	13.34	8	52294	200	42568833
Unresponsive to stimuli	19.61	13.34	7	52295	31396	42537637
Generalised bullous fixed drug eruption	19.58	13.34	10	52292	437	42568596
Spinal pain	19.43	13.34	32	52270	6750	42562283
Adenocarcinoma of appendix	19.42	13.34	7	52295	127	42568906
Heart rate increased	19.42	13.34	22	52280	53233	42515800
Blood thyroid stimulating hormone increased	19.42	13.34	28	52274	5264	42563769
Metastases to soft tissue	19.33	13.34	10	52292	449	42568584
Contusion	19.29	13.34	14	52288	41971	42527062
White blood cell count decreased	19.29	13.34	70	52232	110326	42458707
Influenza	19.27	13.34	29	52273	62146	42506887
Hepatorenal failure	18.93	13.34	11	52291	622	42568411
Chronic fatigue syndrome	18.91	13.34	9	52293	337	42568696
White blood cells urine positive	18.84	13.34	15	52287	1426	42567607
Lordosis	18.79	13.34	9	52293	342	42568691
Encephalopathy	18.71	13.34	14	52288	41319	42527714
Inappropriate schedule of product administration	18.68	13.34	58	52244	95844	42473189
Anxiety disorder	18.63	13.34	17	52285	1946	42567087
Angioedema	18.62	13.34	102	52200	42375	42526658
Depression	18.56	13.34	72	52230	111291	42457742
Suicidal ideation	18.55	13.34	19	52283	48142	42520891
Disorientation	18.46	13.34	91	52211	36298	42532735
Tracheal atresia	18.43	13.34	4	52298	8	42569025
Hydrocholecystis	18.36	13.34	10	52292	499	42568534
Pseudarthrosis	18.35	13.34	6	52296	80	42568953
Immobile	18.33	13.34	20	52282	2838	42566195
Immune-mediated hypothyroidism	18.26	13.34	14	52288	1260	42567773
Inadequate analgesia	18.16	13.34	21	52281	3176	42565857
Benign prostatic hyperplasia	18.13	13.34	62	52240	20990	42548043
Intentional product misuse	18.06	13.34	134	52168	61766	42507267
Arthralgia	18.01	13.34	163	52139	205075	42363958
Dermatitis allergic	17.86	13.34	35	52267	8448	42560585
Nasal congestion	17.71	13.34	7	52295	29494	42539539
Cardiovascular insufficiency	17.70	13.34	16	52286	1810	42567223
Haematocrit abnormal	17.66	13.34	12	52290	894	42568139
Adjustment disorder	17.61	13.34	14	52288	1328	42567705
Drug withdrawal maintenance therapy	17.34	13.34	7	52295	175	42568858
Haematoma	17.11	13.34	74	52228	27949	42541084
Upper gastrointestinal haemorrhage	16.99	13.34	78	52224	30221	42538812
Toxic neuropathy	16.90	13.34	10	52292	585	42568448
COVID-19	16.84	13.34	79	52223	115869	42453164
Rhinorrhoea	16.82	13.34	9	52293	31785	42537248
Chills	16.80	13.34	183	52119	93883	42475150
Administration site discomfort	16.78	13.34	5	52297	48	42568985
Frequent bowel movements	16.77	13.34	3	52299	21404	42547629
Ventricular tachycardia	16.76	13.34	8	52294	30152	42538881
Mineral supplementation	16.74	13.34	6	52296	107	42568926
Sinusitis	16.74	13.34	20	52282	47272	42521761
Hepatic cytolysis	16.73	13.34	6	52296	26838	42542195
Vision blurred	16.68	13.34	25	52277	53674	42515359
Aspiration	16.57	13.34	54	52248	17832	42551201
Lip oedema	16.57	13.34	20	52282	3164	42565869
Anal haemorrhage	16.53	13.34	19	52283	2854	42566179
Jaundice	16.49	13.34	85	52217	34504	42534529
Genitourinary tract infection	16.39	13.34	6	52296	114	42568919
Weight bearing difficulty	16.34	13.34	13	52289	1235	42567798
Quality of life decreased	16.26	13.34	26	52276	5350	42563683
Acute hepatic failure	16.23	13.34	52	52250	17021	42552012
Hypokalaemia	15.94	13.34	146	52156	71575	42497458
Basal ganglia haemorrhage	15.89	13.34	12	52290	1056	42567977
Pulmonary sepsis	15.88	13.34	20	52282	3304	42565729
Splenic lesion	15.70	13.34	8	52294	348	42568685
Urogenital infection bacterial	15.70	13.34	5	52297	61	42568972
Flank pain	15.67	13.34	31	52271	7532	42561501
Haematuria	15.67	13.34	123	52179	57676	42511357
Tinnitus	15.60	13.34	8	52294	28930	42540103
Pulmonary embolism	15.46	13.34	219	52083	119393	42449640
Multiple drug therapy	15.29	13.34	12	52290	1117	42567916
Adverse event	15.22	13.34	5	52297	23635	42545398
Hypoxia	15.21	13.34	40	52262	69746	42499287
Blood pressure fluctuation	15.17	13.34	7	52295	26901	42542132
Wrong technique in product usage process	15.12	13.34	18	52284	42617	42526416
Long QT syndrome	15.04	13.34	19	52283	3148	42565885
Breath sounds normal	15.04	13.34	3	52299	3	42569030
Therapeutic response decreased	14.95	13.34	14	52288	36998	42532035
Cognitive disorder	14.93	13.34	12	52290	34160	42534873
Hallucination	14.92	13.34	30	52272	57477	42511556
Nightmare	14.91	13.34	6	52296	25006	42544027
Spinal cord injury cauda equina	14.86	13.34	6	52296	150	42568883
Psoriasis	14.74	13.34	23	52279	48581	42520452
Thrombocytopenia	14.74	13.34	321	51981	189958	42379075
Premature baby	14.73	13.34	5	52297	23148	42545885
Renal impairment	14.72	13.34	203	52099	110025	42459008
Oral mucosal eruption	14.69	13.34	8	52294	399	42568634
Pulpitis dental	14.66	13.34	10	52292	750	42568283
Blood pressure decreased	14.66	13.34	31	52271	58301	42510732
Intestinal haemorrhage	14.63	13.34	21	52281	3930	42565103
Dysdiadochokinesis	14.61	13.34	7	52295	266	42568767
Somatosensory evoked potentials abnormal	14.43	13.34	6	52296	162	42568871
Fluid intake reduced	14.31	13.34	21	52281	4011	42565022
Skin exfoliation	14.26	13.34	18	52284	41535	42527498
Drug dependence	14.22	13.34	72	52230	29022	42540011
Paraparesis	14.17	13.34	15	52287	2056	42566977
Immune effector cell-associated neurotoxicity syndrome	14.15	13.34	34	52268	9427	42559606
Contraindicated product administered	14.12	13.34	65	52237	25207	42543826
Decreased vibratory sense	14.11	13.34	8	52294	432	42568601
Painful ejaculation	14.07	13.34	6	52296	173	42568860
Erythema multiforme	14.01	13.34	35	52267	9942	42559091
Renal function test abnormal	13.98	13.34	18	52284	3039	42565994
Red blood cell abnormality	13.97	13.34	8	52294	440	42568593
Nail bed inflammation	13.97	13.34	6	52296	176	42568857
Visceral pain	13.91	13.34	5	52297	90	42568943
Thirst	13.91	13.34	33	52269	9075	42559958
Osteoarthritis	13.81	13.34	63	52239	24342	42544691
Ocular icterus	13.78	13.34	18	52284	3083	42565950
Therapeutic product effect incomplete	13.74	13.34	43	52259	70896	42498137
Aspirin-exacerbated respiratory disease	13.70	13.34	7	52295	306	42568727
Accidental exposure to product	13.70	13.34	4	52298	20389	42548644
Haemorrhagic necrotic pancreatitis	13.69	13.34	6	52296	185	42568848
Tonsillitis	13.66	13.34	17	52285	2774	42566259
Pancreatitis	13.58	13.34	20	52282	43248	42525785
Blood folate increased	13.56	13.34	7	52295	313	42568720
Drain site complication	13.51	13.34	3	52299	7	42569026
Disease recurrence	13.50	13.34	10	52292	29668	42539365
Autoimmune nephritis	13.48	13.34	7	52295	317	42568716
Upper respiratory tract irritation	13.46	13.34	4	52298	38	42568995
Therapeutic drug monitoring analysis incorrectly performed	13.46	13.34	7	52295	318	42568715
Primary biliary cholangitis	13.44	13.34	7	52295	319	42568714
Coagulation test abnormal	13.43	13.34	9	52293	655	42568378
Preternatural anus	13.42	13.34	5	52297	100	42568933
Feeling hot	13.41	13.34	6	52296	23476	42545557
Myelosuppression	13.40	13.34	18	52284	40443	42528590
Red blood cells urine positive	13.37	13.34	14	52288	1896	42567137

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	2702.59	12.35	2563	97640	422732	110066364
Product prescribing error	1028.80	12.35	618	99585	50713	110438383
Anaemia	706.87	12.35	1540	98663	545546	109943550
Systemic infection	681.23	12.35	276	99927	9543	110479553
Agranulocytosis	669.55	12.35	508	99695	61252	110427844
Product monitoring error	561.72	12.35	234	99969	8693	110480403
Haematochezia	466.49	12.35	549	99654	114975	110374121
Labelled drug-drug interaction medication error	330.69	12.35	247	99956	29055	110460041
Cross sensitivity reaction	317.17	12.35	136	100067	5431	110483665
Appendicolith	281.18	12.35	170	100033	14085	110475011
Joint swelling	276.72	12.35	37	100166	442808	110046288
Drug ineffective	274.54	12.35	609	99594	1519931	108969165
Fracture	253.39	12.35	197	100006	24591	110464505
Leukopenia	237.45	12.35	458	99745	148333	110340763
Infusion related reaction	228.44	12.35	36	100167	381126	110107970
Malaise	228.01	12.35	166	100037	671653	109817443
Haematemesis	217.33	12.35	268	99935	58840	110430256
Synovitis	213.16	12.35	8	100195	274084	110215012
Appendicitis	205.43	12.35	185	100018	28279	110460817
Polyneuropathy	203.81	12.35	194	100009	31818	110457278
Abdominal discomfort	201.35	12.35	54	100149	393804	110095292
Abdominal pain	197.25	12.35	953	99250	512036	109977060
Tachypnoea	196.22	12.35	209	99994	39186	110449910
Hyponatraemia	195.71	12.35	534	99669	217119	110271977
Arthropathy	192.06	12.35	19	100184	287503	110201593
Ascites	192.02	12.35	320	99883	92488	110396608
Blood phosphorus increased	182.70	12.35	137	100066	16203	110472893
Pallor	179.20	12.35	238	99965	56229	110432867
Restlessness	175.28	12.35	235	99968	56024	110433072
Pemphigus	175.06	12.35	4	100199	214566	110274530
Nausea	173.23	12.35	1793	98410	1233897	109255199
Systemic lupus erythematosus	172.00	12.35	16	100187	254322	110234774
Constipation	169.97	12.35	708	99495	357078	110132018
Treatment failure	168.77	12.35	25	100178	277209	110211887
Vomiting	162.17	12.35	1391	98812	909284	109579812
Dyspnoea	161.65	12.35	1620	98583	1105252	109383844
Toxic epidermal necrolysis	158.76	12.35	225	99978	56502	110432594
Sinusitis	158.72	12.35	37	100166	296651	110192445
Pericarditis	155.89	12.35	11	100192	219103	110269993
Analgesic therapy	154.40	12.35	91	100112	7193	110481903
Therapeutic product effect decreased	153.49	12.35	20	100183	244296	110244800
Tachycardia	151.61	12.35	501	99702	226144	110262952
Aspirin-exacerbated respiratory disease	150.02	12.35	49	100154	899	110488197
Completed suicide	144.91	12.35	23	100180	242358	110246738
Fall	144.87	12.35	989	99214	602493	109886603
Ventricular fibrillation	143.36	12.35	182	100021	41131	110447965
Multiple organ dysfunction syndrome	142.12	12.35	378	99825	151332	110337764
Blood uric acid increased	141.88	12.35	133	100070	21396	110467700
Renal impairment	140.09	12.35	432	99771	188013	110301083
Helicobacter infection	139.04	12.35	6	100197	181871	110307225
Drug therapy	136.23	12.35	84	100119	7207	110481889
Sleep disorder therapy	134.35	12.35	84	100119	7387	110481709
Myasthenia gravis	134.34	12.35	129	100074	21382	110467714
Angioedema	134.18	12.35	284	99919	98216	110390880
Psoriatic arthropathy	131.38	12.35	13	100190	196748	110292348
Oedema peripheral	129.31	12.35	615	99588	328045	110161051
Hyperphosphataemia	127.22	12.35	111	100092	16270	110472826
Folliculitis	126.63	12.35	6	100197	167647	110321449
Sepsis	124.06	12.35	606	99597	326740	110162356
Irritable bowel syndrome	123.63	12.35	6	100197	164209	110324887
Fibromyalgia	123.26	12.35	8	100195	170901	110318195
Arthralgia	120.68	12.35	337	99866	779295	109709801
Maternal exposure during pregnancy	119.25	12.35	41	100162	254842	110234254
Cardiogenic shock	118.97	12.35	198	100005	57140	110431956
Product administration error	116.74	12.35	156	100047	37061	110452035
Product dose omission issue	116.33	12.35	74	100129	321708	110167388
Type 2 diabetes mellitus	115.02	12.35	13	100190	177219	110311877
Electrolyte imbalance	114.30	12.35	154	100049	36874	110452222
Nasopharyngitis	113.38	12.35	114	100089	394247	110094849
Alopecia	112.42	12.35	99	100104	364654	110124442
Drug reaction with eosinophilia and systemic symptoms	112.15	12.35	237	99966	81858	110407238
Dehydration	108.43	12.35	521	99682	278990	110210106
Iron deficiency	106.41	12.35	106	100097	18370	110470726
Abdominal pain lower	105.97	12.35	149	100054	37134	110451962
Drug interaction	105.58	12.35	795	99408	499388	109989708
Gamma-glutamyltransferase increased	104.26	12.35	194	100009	61115	110427981
Migraine	103.24	12.35	16	100187	171636	110317460
Injection site pain	101.69	12.35	19	100184	177903	110311193
Jaundice	101.43	12.35	188	100015	59048	110430048
Erysipelas	97.86	12.35	87	100116	13071	110476025
Rheumatic fever	97.29	12.35	3	100200	122576	110366520
Urosepsis	96.86	12.35	129	100074	30546	110458550
Hypoaesthesia	95.96	12.35	86	100117	314137	110174959
Abdominal distension	94.65	12.35	361	99842	174742	110314354
Blood pressure increased	93.94	12.35	59	100144	258314	110230782
Peripheral swelling	93.71	12.35	138	100065	403896	110085200
Hypokalaemia	92.81	12.35	369	99834	182079	110307017
Cachexia	92.80	12.35	84	100119	12921	110476175
Antacid therapy	91.97	12.35	59	100144	5425	110483671
Osteochondrosis	91.42	12.35	45	100158	2476	110486620
Acute kidney injury	91.36	12.35	928	99275	634502	109854594
Stevens-Johnson syndrome	90.73	12.35	157	100046	46744	110442352
Disturbance in attention	89.39	12.35	183	100020	61812	110427284
Hypophosphataemia	88.99	12.35	129	100074	33053	110456043
Ill-defined disorder	87.01	12.35	18	100185	156835	110332261
Therapeutic drug monitoring analysis not performed	86.94	12.35	40	100163	1891	110487205
Mucosal haemorrhage	86.56	12.35	46	100157	2974	110486122
Anticoagulant therapy	85.78	12.35	56	100147	5305	110483791
Pyrexia	85.30	12.35	1212	98991	897053	109592043
Product use issue	85.19	12.35	94	100109	311601	110177495
Drug-induced liver injury	84.35	12.35	270	99933	119797	110369299
Paresis	83.43	12.35	53	100150	4791	110484305
Neuralgia	83.17	12.35	154	100049	48324	110440772
C-reactive protein abnormal	82.93	12.35	10	100193	129685	110359411
Acute hepatic failure	82.53	12.35	131	100072	36337	110452759
Thrombocytopenia	82.47	12.35	570	99633	348315	110140781
Rheumatoid arthritis	82.27	12.35	90	100113	299523	110189573
Haematoma	81.24	12.35	170	100033	58306	110430790
Upper gastrointestinal haemorrhage	80.81	12.35	155	100048	49941	110439155
Electrocardiogram abnormal	80.59	12.35	92	100111	18617	110470479
Weight increased	79.40	12.35	163	100040	419481	110069615
Cardiac failure congestive	78.43	12.35	20	100183	150980	110338116
Wheezing	77.74	12.35	70	100133	255160	110233936
Therapy non-responder	77.65	12.35	23	100180	157284	110331812
Apathy	75.33	12.35	83	100120	16156	110472940
Abdominal pain upper	74.76	12.35	557	99646	348554	110140542
Dysuria	74.42	12.35	167	100036	60064	110429032
Discomfort	74.04	12.35	52	100151	214655	110274441
Bacterial infection	73.72	12.35	142	100061	45894	110443202
Intentional product use issue	73.13	12.35	70	100133	247836	110241260
Musculoskeletal stiffness	72.56	12.35	88	100115	279734	110209362
Pancytopenia	72.26	12.35	378	99825	209235	110279861
Somnolence	72.07	12.35	489	99714	296960	110192136
Exposure during pregnancy	71.55	12.35	31	100172	167393	110321703
Lower respiratory tract infection	70.14	12.35	70	100133	243036	110246060
Rash	67.62	12.35	451	99752	820513	109668583
Joint range of motion decreased	67.53	12.35	14	100189	121818	110367278
Activated partial thromboplastin time prolonged	67.47	12.35	92	100111	22276	110466820
Transaminases increased	66.61	12.35	165	100038	63225	110425871
Lethargy	65.67	12.35	5	100198	93571	110395525
Contusion	65.28	12.35	69	100134	233292	110255804
Feeling abnormal	64.67	12.35	42	100161	180669	110308427
Off label use	62.42	12.35	971	99232	1499214	108989882
Illness	61.84	12.35	3	100200	82168	110406928
Adverse event	61.36	12.35	12	100191	108797	110380299
Adverse drug reaction	60.89	12.35	11	100192	105548	110383548
Bursitis	60.56	12.35	21	100182	129897	110359199
Peripheral venous disease	60.45	12.35	4	100199	84113	110404983
Malignant neoplasm progression	60.30	12.35	315	99888	174252	110314844
Spinal pain	60.21	12.35	79	100124	18436	110470660
Disorientation	60.08	12.35	170	100033	70501	110418595
Hospitalisation	59.91	12.35	27	100176	142466	110346630
Psoriasis	59.69	12.35	26	100177	139967	110349129
Interstitial lung disease	59.21	12.35	26	100177	139308	110349788
Subileus	59.01	12.35	48	100155	6389	110482707
Gastrointestinal disorder	58.68	12.35	80	100123	241872	110247224
Acute abdomen	58.45	12.35	37	100166	3324	110485772
Syncope	58.34	12.35	348	99855	202188	110286908
Road traffic accident	58.18	12.35	13	100190	107385	110381711
Atrial fibrillation	57.69	12.35	381	99822	229261	110259835
Hepatorenal failure	57.58	12.35	27	100176	1333	110487763
Hepatic enzyme increased	57.05	12.35	129	100074	320763	110168333
Amnesia	56.62	12.35	13	100190	105395	110383701
Mental status changes	56.59	12.35	3	100200	76119	110412977
Death	55.97	12.35	387	99816	698482	109790614
Musculoskeletal pain	54.99	12.35	318	99885	182705	110306391
Chills	54.59	12.35	327	99876	190253	110298843
Gait inability	54.05	12.35	28	100175	136348	110352748
End stage renal disease	54.00	12.35	81	100122	21392	110467704
Depression	52.89	12.35	132	100071	317203	110171893
Hyperaesthesia	52.87	12.35	66	100137	14661	110474435
Arrhythmia	52.11	12.35	160	100043	69415	110419681
Dyschezia	51.89	12.35	36	100167	3771	110485325
Congenital hiatus hernia	51.83	12.35	44	100159	6215	110482881
Immobile	51.55	12.35	48	100155	7654	110481442
Therapeutic product effect incomplete	51.30	12.35	77	100126	223728	110265368
Nasal congestion	51.07	12.35	13	100190	98269	110390827
Bradycardia	50.55	12.35	276	99927	155241	110333855
Gastritis erosive	49.99	12.35	58	100145	11942	110477154
Vascular encephalopathy	49.82	12.35	21	100182	803	110488293
Stress	49.53	12.35	208	99995	105140	110383956
Suspected product quality issue	49.10	12.35	19	100184	580	110488516
Hypersensitivity	48.39	12.35	195	100008	403803	110085293
Hepatitis cholestatic	48.14	12.35	69	100134	17497	110471599
Haematuria	48.05	12.35	175	100028	82830	110406266
Lower limb fracture	47.70	12.35	6	100197	75342	110413754
Mobility decreased	47.65	12.35	89	100114	237333	110251763
Chronic obstructive pulmonary disease	47.08	12.35	210	99993	108948	110380148
Ileus	47.02	12.35	93	100110	30636	110458460
Heart rate decreased	46.93	12.35	9	100194	82747	110406349
Gastritis	46.45	12.35	130	100073	53569	110435527
Nasal disorder	46.22	12.35	35	100168	4199	110484897
Aortic stenosis	46.04	12.35	58	100145	13001	110476095
Headache	45.98	12.35	545	99658	881832	109607264
Injection site reaction	45.86	12.35	12	100191	89058	110400038
Loss of personal independence in daily activities	45.83	12.35	41	100162	149979	110339117
Pelvic fracture	45.41	12.35	60	100143	14094	110475002
Micturition disorder	45.12	12.35	36	100167	4662	110484434
Ear infection	45.03	12.35	3	100200	62729	110426367
Inappropriate schedule of product administration	44.82	12.35	72	100131	203565	110285531
Disease progression	44.27	12.35	97	100106	243937	110245159
Listless	44.23	12.35	35	100168	4480	110484616
Anaphylactic reaction	44.22	12.35	213	99990	114087	110375009
Medication error	44.17	12.35	201	100002	105165	110383931
Blister	44.09	12.35	87	100116	227289	110261807
Neuropathy peripheral	43.74	12.35	59	100144	179218	110309878
Hepatic cyst	43.62	12.35	44	100159	7739	110481357
Bacteroides infection	43.09	12.35	29	100174	2890	110486206
Faecaloma	42.98	12.35	60	100143	14848	110474248
Pleural effusion	42.91	12.35	292	99911	177417	110311679
Flank pain	42.88	12.35	76	100127	23054	110466042
Liver injury	42.58	12.35	44	100159	150369	110338727
Cardiovascular disorder	42.47	12.35	75	100128	22685	110466411
Lordosis	42.35	12.35	16	100187	457	110488639
Heart rate increased	41.95	12.35	41	100162	143793	110345303
Swelling	41.68	12.35	170	100033	350871	110138225
Prostatic pain	41.50	12.35	14	100189	285	110488811
Injection site swelling	41.45	12.35	4	100199	61786	110427310
Arthritis	41.04	12.35	55	100148	167531	110321565
Joint stiffness	41.04	12.35	6	100197	67237	110421859
Hyperventilation	40.24	12.35	45	100158	8902	110480194
Cardiac failure	39.91	12.35	299	99904	187327	110301769
Respiratory tract haemorrhage	39.67	12.35	24	100179	1990	110487106
Autoimmune disorder	39.60	12.35	6	100197	65477	110423619
Depressed level of consciousness	39.03	12.35	203	100000	112075	110377021
Cellulitis	39.03	12.35	34	100169	125982	110363114
Allodynia	38.92	12.35	24	100179	2059	110487037
Immune-mediated hypothyroidism	38.75	12.35	27	100176	2848	110486248
Suspected product contamination	38.57	12.35	13	100190	264	110488832
Myocardial infarction	38.55	12.35	72	100131	192011	110297085
Inflammation	38.28	12.35	73	100130	193165	110295931
Fluid intake reduced	38.25	12.35	39	100164	6947	110482149
Muscle spasms	38.07	12.35	127	100076	278030	110211066
Polyneuropathy in malignant disease	37.92	12.35	15	100188	486	110488610
Incorrect route of product administration	37.87	12.35	136	100067	63925	110425171
Injection site erythema	37.81	12.35	19	100184	94157	110394939
Haemorrhagic erosive gastritis	37.73	12.35	17	100186	765	110488331
Platelet dysfunction	37.41	12.35	15	100188	504	110488592
Urogenital haemorrhage	37.34	12.35	18	100185	946	110488150
Troponin increased	37.29	12.35	83	100120	29683	110459413
Reduced facial expression	37.27	12.35	29	100174	3622	110485474
Gout	37.17	12.35	94	100109	36472	110452624
Platelet count decreased	36.73	12.35	98	100105	230345	110258751
Pulmonary embolism	36.55	12.35	325	99878	214149	110274947
Hepatitis acute	36.53	12.35	63	100140	18703	110470393
Therapeutic response decreased	36.50	12.35	21	100182	96478	110392618
Nail disorder	35.75	12.35	5	100198	57930	110431166
Drug intolerance	35.58	12.35	219	99984	406293	110082803
Gastrointestinal sounds abnormal	35.53	12.35	35	100168	5983	110483113
Injection site pruritus	35.23	12.35	3	100200	51255	110437841
Pain in jaw	35.17	12.35	3	100200	51174	110437922
Toxicity to various agents	35.11	12.35	273	99930	480282	110008814
Pregnancy	35.07	12.35	3	100200	51064	110438032
Leukocytosis	35.05	12.35	118	100085	53710	110435386
Sinobronchitis	34.98	12.35	14	100189	468	110488628
Coronavirus test positive	34.92	12.35	19	100184	1288	110487808
Thirst	34.80	12.35	67	100136	21640	110467456
Febrile infection	34.26	12.35	30	100173	4418	110484678
Circulatory collapse	34.20	12.35	101	100102	42892	110446204
Diabetes mellitus	34.07	12.35	179	100024	99202	110389894
Bronchopulmonary aspergillosis allergic	33.89	12.35	40	100163	8386	110480710
Dizziness	33.33	12.35	848	99355	697345	109791751
Hepatic failure	33.31	12.35	137	100066	68602	110420494
Drug hypersensitivity	32.68	12.35	259	99944	453831	110035265
Gastritis haemorrhagic	31.95	12.35	25	100178	3148	110485948
Blood calcium increased	31.81	12.35	58	100145	17982	110471114
Dementia	31.76	12.35	81	100122	31592	110457504
Anxiety	31.73	12.35	183	100020	344895	110144201
Hypertensive crisis	31.71	12.35	69	100134	24303	110464793
Respiratory arrest	31.69	12.35	7	100196	58292	110430804
Oliguria	31.66	12.35	59	100144	18598	110470498
Drug ineffective for unapproved indication	31.54	12.35	28	100175	102810	110386286
Contraindicated product administered	31.53	12.35	117	100086	248150	110240946
Thrombosis	31.46	12.35	187	100016	108475	110380621
Acute generalised exanthematous pustulosis	31.28	12.35	64	100139	21600	110467496
Ulcer	31.21	12.35	98	100105	43018	110446078
Duodenal ulcer	31	12.35	60	100143	19454	110469642
Spontaneous haemorrhage	30.73	12.35	17	100186	1191	110487905
Rectal haemorrhage	30.71	12.35	38	100165	119795	110369301
Urogenital infection bacterial	30.71	12.35	9	100194	113	110488983
Total lung capacity decreased	30.67	12.35	35	100168	7079	110482017
Insomnia	30.14	12.35	197	100006	360393	110128703
Benign prostatic hyperplasia	30.12	12.35	57	100146	18177	110470919
Mucosal erosion	30.07	12.35	23	100180	2801	110486295
Negative pressure pulmonary oedema	29.98	12.35	14	100189	685	110488411
Hip arthroplasty	29.74	12.35	7	100196	55806	110433290
Gallbladder polyp	29.72	12.35	17	100186	1270	110487826
No adverse event	29.49	12.35	15	100188	73824	110415272
Accidental exposure to product	29.30	12.35	5	100198	50003	110439093
Frequent bowel movements	29.27	12.35	14	100189	71376	110417720
Tumour pain	29.06	12.35	23	100180	2944	110486152
Micturition urgency	28.99	12.35	58	100145	19262	110469834
Food interaction	28.51	12.35	20	100183	2132	110486964
Type I hypersensitivity	28.49	12.35	32	100171	6361	110482735
Pneumonitis	28.44	12.35	141	100062	76390	110412706
Impaired healing	28.17	12.35	88	100115	196629	110292467
Chronic fatigue syndrome	28.07	12.35	17	100186	1412	110487684
Oedema	27.95	12.35	97	100106	209879	110279217
Laryngitis	27.78	12.35	3	100200	42408	110446688
Knee arthroplasty	27.78	12.35	12	100191	64936	110424160
Neuromuscular block prolonged	27.54	12.35	16	100187	1231	110487865
Therapy cessation	27.38	12.35	4	100199	44853	110444243
Osteoma	26.70	12.35	8	100195	109	110488987
Lung opacity	26.56	12.35	42	100161	11610	110477486
Drug resistance	26.46	12.35	9	100194	56365	110432731
Cardio-respiratory arrest	26.39	12.35	40	100163	115796	110373300
Pulmonary sepsis	26.27	12.35	28	100175	5250	110483846
Fluid retention	26.23	12.35	28	100175	94279	110394817
Vertigo	26.11	12.35	151	100052	86719	110402377
Dehiscence	25.92	12.35	13	100190	745	110488351
Petechiae	25.88	12.35	62	100141	23255	110465841
Oesophageal ulcer haemorrhage	25.88	12.35	14	100189	938	110488158
Coombs negative haemolytic anaemia	25.79	12.35	12	100191	582	110488514
Accessory spleen	25.77	12.35	9	100194	204	110488892
Lack of application site rotation	25.70	12.35	7	100196	66	110489030
Orthostatic hypotension	25.66	12.35	14	100189	66235	110422861
Red blood cell sedimentation rate increased	25.64	12.35	20	100183	78282	110410814
Conjunctivitis	25.57	12.35	78	100125	33714	110455382
Facial nerve disorder	25.53	12.35	13	100190	769	110488327
Lung disorder	25.46	12.35	81	100122	179966	110309130
Unresponsive to stimuli	25.41	12.35	13	100190	63777	110425319
Wound infection	25.34	12.35	30	100173	96435	110392661
Anaemia of malignant disease	25.29	12.35	14	100189	982	110488114
Unevaluable event	25.24	12.35	11	100192	59216	110429880
Gastroenteritis	25.21	12.35	85	100118	38715	110450381
Abnormal behaviour	24.98	12.35	3	100200	39036	110450060
Central pain syndrome	24.95	12.35	13	100190	807	110488289
Confusional state	24.92	12.35	288	99915	468392	110020704
Urinary retention	24.91	12.35	127	100076	69556	110419540
Rhinorrhoea	24.82	12.35	34	100169	102632	110386464
Angina pectoris	24.75	12.35	117	100086	62178	110426918
Influenza	24.67	12.35	75	100128	169026	110320070
Prerenal failure	24.61	12.35	25	100178	4434	110484662
Onychomycosis	24.56	12.35	3	100200	38528	110450568
Parapharyngeal space infection	24.55	12.35	5	100198	10	110489086
Asthma	24.49	12.35	130	100073	250161	110238935
Vision blurred	24.46	12.35	50	100153	128972	110360124
Adjustment disorder with depressed mood	24.40	12.35	5	100198	43878	110445218
Mononeuropathy	24.21	12.35	10	100193	363	110488733
Neutropenic colitis	24.06	12.35	33	100170	8032	110481064
Sciatica	23.99	12.35	29	100174	92370	110396726
Bicytopenia	23.92	12.35	30	100173	6694	110482402
Spinal osteoarthritis	23.86	12.35	55	100148	20128	110468968
Condition aggravated	23.82	12.35	851	99352	733985	109755111
Pain in extremity	23.74	12.35	305	99898	486813	110002283
Lower gastrointestinal haemorrhage	23.67	12.35	52	100151	18434	110470662
White blood cell count decreased	23.66	12.35	117	100086	229273	110259823
Immune-mediated enterocolitis	23.61	12.35	37	100166	10148	110478948
Stomatitis	23.42	12.35	146	100057	270096	110219000
Blood pressure fluctuation	23.39	12.35	20	100183	74804	110414292
Prescribed overdose	23.26	12.35	27	100176	87554	110401542
Polycystic liver disease	23.22	12.35	8	100195	174	110488922
Rash pruritic	23.19	12.35	33	100170	98036	110391060
Product used for unknown indication	23.16	12.35	17	100186	1946	110487150
Cardiac disorder	23.11	12.35	21	100182	76259	110412837
Hyperglycaemia	23.08	12.35	144	100059	84946	110404150
Cardiac arrest	22.89	12.35	96	100107	196657	110292439
Nail toxicity	22.84	12.35	10	100193	420	110488676
Respiratory alkalosis	22.75	12.35	27	100176	5694	110483402
Splenic necrosis	22.68	12.35	8	100195	187	110488909
Aspiration	22.66	12.35	70	100133	30463	110458633
Chromaturia	22.43	12.35	68	100135	29292	110459804
Immune-mediated hepatitis	22.39	12.35	29	100174	6682	110482414
Exostosis	22.16	12.35	7	100196	45949	110443147
Intentional overdose	22.16	12.35	200	100003	132301	110356795
Hyperlipidaemia	21.95	12.35	77	100126	35771	110453325
Pneumobilia	21.94	12.35	9	100194	321	110488775
Disease recurrence	21.91	12.35	14	100189	60770	110428326
Orthostatic intolerance	21.84	12.35	17	100186	2124	110486972
Muscle tone disorder	21.53	12.35	8	100195	218	110488878
Dry eye	21.30	12.35	12	100191	55781	110433315
Brain contusion	21.27	12.35	15	100188	1613	110487483
Thirst decreased	20.92	12.35	9	100194	362	110488734
Psychotic disorder	20.87	12.35	10	100193	50927	110438169
Gastric ulcer perforation	20.85	12.35	17	100186	2271	110486825
Therapeutic drug monitoring analysis incorrectly performed	20.84	12.35	11	100192	701	110488395
Blood pressure measurement	20.84	12.35	10	100193	520	110488576
Post-traumatic pain	20.82	12.35	10	100193	521	110488575
Cold sweat	20.71	12.35	55	100148	21976	110467120
Intentional product misuse	20.42	12.35	197	100006	132707	110356389
Throat tightness	20.41	12.35	3	100200	33486	110455610
Iron deficiency anaemia	20.38	12.35	69	100134	31490	110457606
Product quality issue	20.35	12.35	24	100179	77275	110411821
Lupus-like syndrome	20.06	12.35	6	100197	40786	110448310
Pulmonary fibrosis	19.81	12.35	39	100164	102003	110387093
Hydrocholecystis	19.71	12.35	10	100193	587	110488509
Blood folate increased	19.70	12.35	10	100193	588	110488508
Haemorrhagic necrotic pancreatitis	19.59	12.35	7	100196	170	110488926
Generalised bullous fixed drug eruption	19.59	12.35	11	100192	793	110488303
Thoracic vertebral fracture	19.51	12.35	27	100176	6628	110482468
Medication overuse headache	19.49	12.35	14	100189	1549	110487547
Head discomfort	19.48	12.35	49	100154	18951	110470145
Splenic cyst	19.46	12.35	8	100195	287	110488809
Basal ganglia haemorrhage	19.28	12.35	15	100188	1873	110487223
Immune-mediated hyperthyroidism	19.23	12.35	10	100193	618	110488478
Peripheral arterial occlusive disease	19.18	12.35	32	100171	9248	110479848
Confusional arousal	19.11	12.35	7	100196	183	110488913
Dysdiadochokinesis	19.11	12.35	9	100194	449	110488647
Anal haemorrhage	19.08	12.35	23	100180	4929	110484167
Blood pressure decreased	19.06	12.35	48	100155	115043	110374053
Mixed liver injury	19.02	12.35	37	100166	12042	110477054
Sensory disturbance	18.98	12.35	46	100157	17383	110471713
Shock haemorrhagic	18.87	12.35	61	100142	27186	110461910
Painful respiration	18.87	12.35	20	100183	3727	110485369
Hepatitis toxic	18.84	12.35	25	100178	5896	110483200
Foreign body	18.77	12.35	18	100185	2977	110486119
Pseudarthrosis	18.76	12.35	8	100195	315	110488781
Painful ejaculation	18.74	12.35	6	100197	103	110488993
Flatulence	18.61	12.35	95	100108	52054	110437042
Rhabdomyolysis	18.58	12.35	52	100151	120349	110368747
Gastroenteritis viral	18.56	12.35	3	100200	31223	110457873
Blood thyroid stimulating hormone increased	18.54	12.35	37	100166	12264	110476832
Paraesthesia oral	18.39	12.35	4	100199	33667	110455429
Memory impairment	18.33	12.35	104	100099	196840	110292256
Anaemia folate deficiency	18.20	12.35	10	100193	691	110488405
Necrotising fasciitis	18.19	12.35	28	100175	7563	110481533
Lip oedema	18.16	12.35	28	100175	7572	110481524
Long QT syndrome	18.11	12.35	27	100176	7091	110482005
Metastases to soft tissue	17.96	12.35	10	100193	709	110488387
Tonsillitis	17.89	12.35	29	100174	8184	110480912
Allergic sinusitis	17.86	12.35	14	100189	1767	110487329
Folate deficiency	17.73	12.35	21	100182	4417	110484679
Reactive gastropathy	17.68	12.35	10	100193	731	110488365
Activated partial thromboplastin time abnormal	17.55	12.35	8	100195	370	110488726
Catheter site inflammation	17.55	12.35	12	100191	1228	110487868
Obesity	17.46	12.35	49	100154	113302	110375794
Chronic gastritis	17.46	12.35	23	100180	5388	110483708
Labelled drug-drug interaction issue	17.38	12.35	20	100183	4081	110485015
Ileus paralytic	17.33	12.35	35	100168	11702	110477394
Wrong technique in product usage process	17.29	12.35	33	100170	87315	110401781
Dysphagia	17.28	12.35	214	99989	153386	110335710
Face oedema	17.24	12.35	68	100135	33401	110455695
Autoimmune thyroiditis	17.23	12.35	25	100178	6409	110482687
Blood test abnormal	17.20	12.35	61	100142	28493	110460603
Prescription drug used without a prescription	17.17	12.35	23	100180	5473	110483623
Drug dependence	17.07	12.35	90	100113	49930	110439166
Rash erythematous	17.01	12.35	30	100173	81802	110407294
Hyperaemia	17.01	12.35	19	100184	3754	110485342
Helicobacter gastritis	16.92	12.35	16	100187	2600	110486496
Tinnitus	16.80	12.35	18	100185	60522	110428574
Spinal cord injury cauda equina	16.63	12.35	6	100197	150	110488946
Aortic arteriosclerosis	16.61	12.35	33	100170	10905	110478191
Deficiency of bile secretion	16.56	12.35	5	100198	70	110489026
Neck pain	16.30	12.35	57	100146	123073	110366023
Implant site inflammation	16.26	12.35	7	100196	282	110488814
Incisional hernia	16.26	12.35	16	100187	2731	110486365
Glomerular filtration rate abnormal	16.24	12.35	15	100188	2368	110486728
Diverticulum intestinal	16.19	12.35	34	100169	11685	110477411
Rash maculo-papular	16.18	12.35	119	100084	74103	110414993
VIIIth nerve injury	15.99	12.35	4	100199	26	110489070
Breath sounds normal	15.95	12.35	3	100200	3	110489093
Colitis	15.88	12.35	152	100051	102171	110386925
Feeling hot	15.87	12.35	37	100166	91069	110398027
Drain site complication	15.86	12.35	4	100199	27	110489069
Eye pruritus	15.79	12.35	5	100198	32770	110456326
Hepatic function abnormal	15.77	12.35	36	100167	89259	110399837
Peritoneal perforation	15.76	12.35	6	100197	175	110488921
Hypervolaemia	15.73	12.35	13	100190	49447	110439649
Disability	15.69	12.35	4	100199	30219	110458877
Nodule	15.68	12.35	5	100198	32626	110456470
Viral infection	15.66	12.35	15	100188	53124	110435972
Paraparesis	15.65	12.35	20	100183	4546	110484550
Lumbar vertebral fracture	15.65	12.35	29	100174	9102	110479994
Drug tolerance decreased	15.60	12.35	3	100200	27537	110461559
Cardiovascular insufficiency	15.59	12.35	17	100186	3271	110485825
Bulimia nervosa	15.58	12.35	7	100196	313	110488783
Haemolytic anaemia	15.56	12.35	48	100155	20872	110468224
Adrenal calcification	15.50	12.35	4	100199	30	110489066
Head injury	15.38	12.35	10	100193	43007	110446089
Cholecystitis	15.34	12.35	55	100148	25827	110463269
Gastrooesophageal reflux disease	15.19	12.35	98	100105	179878	110309218
Product impurity	15.14	12.35	5	100198	95	110489001
Joint dislocation	15.13	12.35	6	100197	34184	110454912
Immune effector cell-associated neurotoxicity syndrome	15.02	12.35	38	100165	14744	110474352
Cyanosis	14.98	12.35	60	100143	29681	110459415
Internal fixation of fracture	14.94	12.35	8	100195	525	110488571
Hyperchromic anaemia	14.92	12.35	6	100197	203	110488893
Preternatural anus	14.91	12.35	5	100198	100	110488996
Swelling face	14.90	12.35	39	100164	92282	110396814
Oedema mucosal	14.88	12.35	14	100189	2262	110486834
Pleuritic pain	14.88	12.35	40	100163	16100	110472996
Acute myeloid leukaemia	14.84	12.35	8	100195	38102	110450994
Somatosensory evoked potentials abnormal	14.81	12.35	6	100197	207	110488889
Hyperthyroidism	14.71	12.35	59	100144	29202	110459894
Pulmonary hypertension	14.69	12.35	17	100186	55203	110433893
Cerebrovascular accident	14.65	12.35	100	100103	181184	110307912
Papillary renal cell carcinoma	14.63	12.35	7	100196	362	110488734
Cardiac murmur functional	14.57	12.35	4	100199	39	110489057
Nocturia	14.56	12.35	41	100162	16949	110472147
Concomitant disease aggravated	14.53	12.35	40	100163	16324	110472772
Necrosis	14.50	12.35	32	100171	11374	110477722
Pancreatic failure	14.48	12.35	14	100189	2340	110486756
Dyspnoea exertional	14.42	12.35	151	100052	103909	110385187
Atheroembolism	14.41	12.35	7	100196	374	110488722
Autoimmune nephritis	14.36	12.35	9	100194	795	110488301
Vascular device infection	14.30	12.35	40	100163	16472	110472624
Genital erosion	14.28	12.35	9	100194	802	110488294
Product packaging confusion	14.27	12.35	7	100196	382	110488714
Nail bed inflammation	14.26	12.35	13	100190	2017	110487079
Eyelid oedema	14.24	12.35	38	100165	15224	110473872
Septic shock	14.23	12.35	211	99992	157317	110331779
Surgery	14.22	12.35	10	100193	41273	110447823
Subacute hepatic failure	14.20	12.35	6	100197	231	110488865
Product confusion	14.12	12.35	6	100197	234	110488862
Cataract	14.07	12.35	32	100171	79453	110409643
Kidney infection	14.06	12.35	3	100200	25596	110463500
Haematocrit abnormal	13.98	12.35	12	100191	1721	110487375
Autoimmune hepatitis	13.96	12.35	37	100166	14767	110474329
SARS-CoV-2 antibody test negative	13.93	12.35	7	100196	403	110488693
Lividity	13.92	12.35	8	100195	603	110488493
Necrolytic migratory erythema	13.87	12.35	3	100200	9	110489087
Toxic neuropathy	13.87	12.35	10	100193	1113	110487983
Urine uric acid decreased	13.86	12.35	5	100198	125	110488971
Costovertebral angle tenderness	13.84	12.35	6	100197	246	110488850
Visual acuity reduced	13.67	12.35	6	100197	32167	110456929
Paraplegia	13.65	12.35	22	100181	6178	110482918
Pulmonary vein occlusion	13.64	12.35	5	100198	131	110488965
Splenic lesion	13.63	12.35	8	100195	627	110488469
Hypertensive emergency	13.63	12.35	16	100187	3335	110485761
Solar dermatitis	13.62	12.35	6	100197	256	110488840
Ear pain	13.51	12.35	17	100186	53209	110435887
Impaired self-care	13.47	12.35	14	100189	2550	110486546
Tracheal pain	13.38	12.35	4	100199	54	110489042
Cholestatic liver injury	13.37	12.35	24	100179	7352	110481744
Visceral pain	13.36	12.35	5	100198	139	110488957
Mesenteric arterial occlusion	13.36	12.35	6	100197	268	110488828
Non-small cell lung cancer	13.35	12.35	25	100178	7910	110481186
Cardiac murmur	13.30	12.35	3	100200	24625	110464471
Anti-saccharomyces cerevisiae antibody test positive	13.25	12.35	4	100199	56	110489040
Osteoarthritis	13.19	12.35	104	100099	182519	110306577
Prostatic specific antigen abnormal	13.14	12.35	8	100195	671	110488425
Hypertransaminasaemia	13.08	12.35	50	100153	24205	110464891
Urinary sediment abnormal	13.07	12.35	5	100198	148	110488948
Pulpitis dental	13.05	12.35	11	100192	1538	110487558
Localised infection	13.05	12.35	75	100128	42973	110446123
Hyperresponsive to stimuli	12.99	12.35	4	100199	60	110489036
Teething	12.97	12.35	5	100198	151	110488945
Leptotrichia infection	12.87	12.35	4	100199	62	110489034
Thyroid cyst	12.86	12.35	7	100196	475	110488621
Alpha 2 globulin increased	12.82	12.35	5	100198	156	110488940
Foot deformity	12.81	12.35	15	100188	48465	110440631
Gastroduodenal ulcer	12.81	12.35	9	100194	962	110488134
Product use in unapproved indication	12.81	12.35	308	99895	447069	110042027
Coma	12.80	12.35	59	100144	117810	110371286
Paraesthesia	12.78	12.35	175	100028	276346	110212750
Hypercholesterolaemia	12.74	12.35	41	100162	90796	110398300
Dermatitis allergic	12.73	12.35	46	100157	21678	110467418
Mechanical ileus	12.72	12.35	10	100193	1267	110487829
Decreased vibratory sense	12.71	12.35	8	100195	712	110488384
Anxiety disorder	12.66	12.35	19	100184	5021	110484075
Genitourinary tract infection	12.61	12.35	6	100197	306	110488790
Hyperkinesia	12.61	12.35	15	100188	3169	110485927
Gouty arthritis	12.40	12.35	11	100192	1648	110487448
Neutropenia	12.39	12.35	435	99768	374185	110114911

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02BB02	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB52	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB72	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
MeSH PA	D000700	Analgesics
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018689	Sensory System Agents
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D058633	Antipyretics
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:55323	antidiarrhoeal drug
CHEBI has role	CHEBI:35481	non-narcotic analgesic
CHEBI has role	CHEBI:35493	antipyretic
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:49110	peripheral nervous system drug
CHEBI has role	CHEBI:50266	prodrug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:73263	cyclooxygenase 3 inhibitor

Related Drugs by ATC class:

N02BB Pyrazolones 4 drugs

aminophenazone nifenazone phenazone propyphenazone

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Zimeta	Kindred Biosciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.21	acidic
pKa2	5.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	BLOCKER	IC50	4.04		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D08190	KEGG_DRUG
N0000167060	NUI
50567-35-6	SECONDARY_CAS_RN
CHEMBL461522	ChEMBL_ID
CHEMBL3989803	ChEMBL_ID
10608	IUPHAR_LIGAND_ID
5907-38-0	SECONDARY_CAS_RN
DB04817	DRUGBANK_ID
934T64RMNJ	UNII
1537943	RXNORM
NOCODE	MMSL
001609	NDDF
006029	NDDF
22165008	SNOMEDCT_US
735071007	SNOMEDCT_US
780831000	SNOMEDCT_US
781025005	SNOMEDCT_US
C0012586	UMLSCUI
D004177	MESH_DESCRIPTOR_UI
CHEBI:59033	CHEBI
3111	PUBCHEM_CID
6150-97-6	SECONDARY_CAS_RN
51996-59-9	SECONDARY_CAS_RN
477	INN_ID
C024864	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None

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Using the assistant

metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: