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halcinonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids for topical use, acetal derivatives | 4507 | 3093-35-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 16 | |||
| kinase-selectivity-class | GRK2 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 27, 1974 | FDA | RANBAXY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AD02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, very potent (group IV) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:131809 | SMO receptor agonist |
Related Drugs by ATC class:
D07AD Corticosteroids, very potent (group IV) 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Tuberculosis of skin | contraindication | 66986005 | |
| Bilateral cataracts | contraindication | 95722004 | |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.17 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 9.14 | DRUG MATRIX | CHEMBL | |||
| Androgen receptor | Transcription factor | Ki | 6.23 | DRUG MATRIX | |||||
| Progesterone receptor | Transcription factor | Ki | 9.92 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| D01308 | KEGG_DRUG |
| 4017606 | VUID |
| N0000145986 | NUI |
| 4017606 | VANDF |
| CHEBI:31663 | CHEBI |
| CHEMBL1200845 | ChEMBL_ID |
| 3392 | INN_ID |
| DB06786 | DRUGBANK_ID |
| SI86V6QNEG | UNII |
| 227517 | RXNORM |
| 321821 | MMSL |
| 4814 | MMSL |
| 579 | MMSL |
| 002200 | NDDF |
| 29058003 | SNOMEDCT_US |
| 395735005 | SNOMEDCT_US |
| C0018513 | UMLSCUI |
| D006206 | MESH_DESCRIPTOR_UI |
| 443943 | PUBCHEM_CID |
| SI86V6QNEG | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Halcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8056 | CREAM | 1 mg | TOPICAL | ANDA | 21 sections |
| Halog | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10631-094 | CREAM | 1 mg | TOPICAL | NDA | 20 sections |
| HALCINONIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57664-698 | CREAM | 1 mg | TOPICAL | NDA authorized generic | 20 sections |
| HALCINONIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 57664-698 | CREAM | 1 mg | TOPICAL | NDA authorized generic | 20 sections |
| Halog | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64950-126 | CREAM | 1 mg | TOPICAL | NDA | 20 sections |
| HALOG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64950-127 | SOLUTION | 1 mg | TOPICAL | NDA | 18 sections |
| Halcinonide Topical Solution | HUMAN PRESCRIPTION DRUG LABEL | 1 | 74157-012 | SOLUTION | 1 mg | TOPICAL | ANDA | 18 sections |