procaine benzylpenicillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 4459 54-35-3

Description:

MoleculeDescription

Synonyms:

  • penicillin G procaine
  • procaine benzylpenicillin
Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.
  • Molecular weight: 570.71
  • Formula: C29H38N4O6S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 86.71
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.60 g P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 26, 1948 FDA KING PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 195.21 104.74 48 37 463561 90164801

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 176.11 81.59 49 98 454041 110135111

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01CE09 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Beta-lactamase sensitive penicillins
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:53000 epitope
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:35441 antiinfective agent

Related Drugs by ATC class:

J01CE Beta-lactamase sensitive penicillins 9 drugs
azidocillinbenzathine benzylpenicillinbenzathine phenoxymethylpenicillinbenzylpenicillinclometocillinpenamecillinpheneticillinphenoxymethylpenicillinpropicillin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rat bite fever indication 1685005
Acute otitis media indication 3110003
Infection of skin AND/OR subcutaneous tissue indication 19824006
Gingivostomatitis indication 20607006
Pinta indication 22064009 DOID:1022
Neurosyphilis indication 26039008 DOID:9988
Scarlet fever indication 30242009 DOID:8596
Pneumonia due to Streptococcus indication 34020007
Congenital syphilis indication 35742006 DOID:9856
Streptococcal tonsillitis indication 41582007
Erysipelas indication 44653001 DOID:11330
Yaws indication 70647001 DOID:10371
Late syphilis indication 72083004 DOID:8200
Syphilis indication 76272004
Streptococcal infectious disease indication 85769006
Primary genital syphilis indication 186847001
Pneumococcal pneumonia indication 233607000
Secondary syphilis indication 240557004 DOID:4157
Bejel indication 240686008 DOID:13431
Bacterial endocarditis indication 301183007
Streptococcus pyogenes infection indication 302809008
Diphtheria indication 397428000
Fusospirochetal pharyngitis indication 399095008
Erysipeloid indication 400105005
Pharyngitis indication 405737000 DOID:2275
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Latent syphilis indication 444150000 DOID:9531
Asymptomatic Congenital Syphilis indication
Upper Respiratory Pneumococcal Infection indication
Streptococcal Endocarditis indication
Pneumococcal Acute Otitis Media indication
Kidney disease contraindication 90708001 DOID:557
Infectious mononucleosis contraindication 271558008 DOID:8568
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Bacterial infections Indication
Cats Bacterial infections Indication
Cattle Mastitis caused by Staphylococcus aureus Indication
Cattle Mastitis caused by Streptococcus agalactiae Indication
Cattle Mastitis caused by Streptococcus dysgalactiae Indication
Cattle Mastitis caused by Streptococcus uberis Indication
Cattle Intramammary use to reduce the frequency of existing infection and to prevent new infections with Staphylococcus aureus Indication
Cattle Bacterial pneumonia caused by Pasteurella multocida Indication
Cattle Bacterial infections Indication
Horses Strangles caused by Streptococcus equi Indication
Horses Bacterial infections Indication
Sheep Bacterial pneumonia caused by Pasteurella multocida Indication
Swine Erysipelas caused by Erysipelothrix rhusiopathiae Indication

🐶 Veterinary products

ProductApplicantIngredients
Quartermaster Suspension HQ Specialty Pharma Corp. 2
Albacillin Suspension, Special Formula 17900-Forte Suspension Zoetis Inc. 2
Dry-Mast HQ Specialty Pharma Corp. 2
Albadry Plus Suspension Zoetis Inc. 2
Norocillin Norbrook Laboratories, Ltd. 1
Go-Dry, Masti-Clear HQ Specialty Pharma Corp. 1
Longicil Fortified Zoetis Inc. 2
PEN-G-MAX Huvepharma EOOD 1
Forte Topical Ointment Zoetis Inc. 4
Crystalline Pro Penicillin G Zoetis Inc. 1
Dura-biotic, Flo-cillin Zoetis Inc. 2
Crysticillin Zoetis Inc. 1
Formula A-34, Uni Biotic 4 Dose Bimeda Animal Health Limited 1
Dual-Cillin, Pen BP-48 Huvepharma EOOD 2
Pro-Pen-G Bimeda Animal Health Limited 1
Combi-PEN-48 Bimeda Animal Health Limited 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02461 KEGG_DRUG
4017437 VUID
N0000145825 NUI
6130-64-9 SECONDARY_CAS_RN
4017437 VANDF
4017440 VANDF
CHEBI:749925 CHEBI
CHEMBL1628385 ChEMBL_ID
CHEMBL1200936 ChEMBL_ID
DB09320 DRUGBANK_ID
5903 PUBCHEM_CID
7980 RXNORM
160608 MMSL
45788 MMSL
5246 MMSL
d07390 MMSL
002681 NDDF
004977 NDDF
323389000 SNOMEDCT_US
387246005 SNOMEDCT_US
449005 SNOMEDCT_US
78507004 SNOMEDCT_US
C0030830 UMLSCUI
D010402 MESH_DESCRIPTOR_UI
C0030827 UMLSCUI
DB01053 DRUGBANK_ID
5904 PUBCHEM_CID
17R794ESYN UNII
CHEBI:18208 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BICILLIN CR HUMAN PRESCRIPTION DRUG LABEL 2 50090-1815 INJECTION, SUSPENSION 600000 [iU] INTRAMUSCULAR NDA 24 sections
BICILLIN CR HUMAN PRESCRIPTION DRUG LABEL 2 54868-5932 INJECTION, SUSPENSION 600000 [iU] INTRAMUSCULAR NDA 22 sections
BICILLIN CR HUMAN PRESCRIPTION DRUG LABEL 2 60793-600 INJECTION, SUSPENSION 600000 [iU] INTRAMUSCULAR NDA 26 sections
BICILLIN CR HUMAN PRESCRIPTION DRUG LABEL 2 60793-601 INJECTION, SUSPENSION 600000 [iU] INTRAMUSCULAR NDA 26 sections
BICILLIN C-R 900/300 HUMAN PRESCRIPTION DRUG LABEL 2 60793-602 INJECTION, SUSPENSION 300000 [iU] INTRAMUSCULAR NDA 26 sections
BICILLIN CR HUMAN PRESCRIPTION DRUG LABEL 2 68258-8910 INJECTION, SUSPENSION 600000 [iU] INTRAMUSCULAR NDA 24 sections