iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
radiopharmaceuticals, iodine-contained 4446 7553-56-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iodine
A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
  • Molecular weight: 253.81
  • Formula: I2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,KDR,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 67
kinase-selectivity-class DYRK1B,EIF2AK3,GRK2,MAP2K1,MAPK1,PIK3CB 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 919.02 16.77 730 16359 462879 90148479
Iodine allergy 80.69 16.77 21 17068 865 90610493
Onychomycosis 67.19 16.77 56 17033 37320 90574038
Onychomadesis 66.74 16.77 61 17028 45937 90565421
Psoriatic arthropathy 60.30 16.77 133 16956 228202 90383156
Type 2 diabetes mellitus 58.97 16.77 123 16966 203121 90408237
Rheumatic fever 44.78 16.77 93 16996 153028 90458330
Urinary tract discomfort 43.41 16.77 13 17076 899 90610459
Subcutaneous drug absorption impaired 41.62 16.77 28 17061 13517 90597841
Sleep disorder 40.00 16.77 104 16985 197926 90413432
Alveolar osteitis 36.11 16.77 12 17077 1165 90610193
Lipoedema 35.33 16.77 9 17080 340 90611018
Fibromyalgia 34.39 16.77 101 16988 206168 90405190
Hypercholesterolaemia 33.95 16.77 65 17024 100827 90510531
Death 32.85 16.77 23 17066 456528 90154830
Wound infection 32.72 16.77 66 17023 106336 90505022
Thymoma 32.28 16.77 8 17081 270 90611088
Rash vesicular 32.15 16.77 27 17062 18170 90593188
Calculus urinary 31.81 16.77 12 17077 1686 90609672
Tunnel vision 31.79 16.77 12 17077 1689 90609669
Drug ineffective 31.78 16.77 144 16945 1384154 89227204
Pustular psoriasis 31.69 16.77 27 17062 18529 90592829
Breast cancer stage II 31.42 16.77 36 17053 35298 90576060
Animal scratch 30.94 16.77 12 17077 1818 90609540
General symptom 30.64 16.77 24 17065 14644 90596714
Wound 27.81 16.77 122 16967 302858 90308500
Neutropenia 26.76 16.77 5 17084 224899 90386459
Bladder pain 26.28 16.77 12 17077 2725 90608633
Adjustment disorder with depressed mood 26.16 16.77 42 17047 56711 90554647
Liver injury 26.05 16.77 81 17008 170486 90440872
Pericarditis 25.72 16.77 110 16979 270041 90341317
Gait inability 25.64 16.77 73 17016 146383 90464975
Facet joint syndrome 25.58 16.77 57 17032 98332 90513026
Fistula discharge 25.34 16.77 9 17080 1066 90610292
Wound secretion 24.75 16.77 14 17075 4976 90606382
Migraine 24.23 16.77 85 17004 190307 90421051
Ear congestion 23.66 16.77 12 17077 3430 90607928
Grip strength decreased 23.36 16.77 53 17036 92523 90518835
Bronchopulmonary aspergillosis allergic 22.64 16.77 12 17077 3754 90607604
Back disorder 22.59 16.77 26 17063 25605 90585753
Anaemia 22.55 16.77 20 17069 352782 90258576
Ill-defined disorder 22.21 16.77 81 17008 184810 90426548
Thrombocytopenia 22.10 16.77 6 17083 208719 90402639
Spinal cord disorder 22.06 16.77 9 17080 1556 90609802
Blepharospasm 21.52 16.77 38 17051 55407 90555951
Vascular injury 21.36 16.77 8 17081 1102 90610256
Systemic lupus erythematosus 20.86 16.77 128 16961 361768 90249590
Folliculitis 20.84 16.77 85 17004 204268 90407090
Dyspepsia 20.67 16.77 83 17006 198077 90413281
Myositis 20.47 16.77 24 17065 24104 90587254
Joint range of motion decreased 20.32 16.77 64 17025 135579 90475779
Wound complication 20.01 16.77 12 17077 4751 90606607
C-reactive protein abnormal 19.90 16.77 61 17028 127368 90483990
Bladder spasm 19.80 16.77 9 17080 2021 90609337
Polymyalgia rheumatica 19.52 16.77 12 17077 4965 90606393
Rheumatoid arthritis 19.49 16.77 126 16963 362488 90248870
Paranasal sinus discomfort 19.47 16.77 13 17076 6197 90605161
Sepsis 19.36 16.77 5 17084 179809 90431549
Relapsing multiple sclerosis 18.89 16.77 5 17084 220 90611138
Infected lymphocele 18.72 16.77 5 17084 228 90611130
Sinus pain 18.65 16.77 12 17077 5377 90605981
Oedema 18.63 16.77 81 17008 200214 90411144
Synovitis 18.60 16.77 116 16973 329636 90281722
Injury 18.50 16.77 80 17009 197269 90414089
Dry mouth 18.33 16.77 76 17013 183983 90427375
Dislocation of vertebra 17.53 16.77 35 17054 55933 90555425
X-ray abnormal 17.46 16.77 31 17058 45393 90565965

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 312.80 25.99 124 1555 99265 42520391
Foetal exposure during pregnancy 69.84 25.99 35 1644 47276 42572380
Dysmorphism 42.42 25.99 12 1667 3304 42616352
Epispadias 41.73 25.99 7 1672 162 42619494
Iodine allergy 33.73 25.99 5 1674 50 42619606
Premature baby 30.81 25.99 16 1663 23137 42596519
Anaphylactic reaction 26.41 25.99 18 1661 42725 42576931

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 950.43 18.61 685 16589 453405 110118620
Psoriatic arthropathy 88.50 18.61 130 17144 196631 110375394
Type 2 diabetes mellitus 88.38 18.61 123 17151 177109 110394916
Onychomycosis 77.24 18.61 57 17217 38474 110533551
Onychomadesis 77.14 18.61 61 17213 45602 110526423
Rheumatic fever 73.29 18.61 93 17181 122486 110449539
Subcutaneous drug absorption impaired 64.67 18.61 29 17245 7630 110564395
Wound 64.09 18.61 124 17150 234313 110337712
Systemic lupus erythematosus 61.71 18.61 128 17146 254210 110317815
Fibromyalgia 54.99 18.61 97 17177 170812 110401213
Iodine allergy 54.03 18.61 14 17260 687 110571338
Toxicity to various agents 51.59 18.61 7 17267 480548 110091477
Pericarditis 50.49 18.61 108 17166 219006 110353019
General symptom 48.79 18.61 25 17249 8821 110563204
Death 47.52 18.61 25 17249 698844 109873181
Wound infection 46.63 18.61 66 17208 96399 110475626
Pustular psoriasis 46.34 18.61 28 17246 13577 110558448
Pemphigus 45.17 18.61 102 17172 214468 110357557
Urinary tract discomfort 44.90 18.61 13 17261 967 110571058
Rheumatoid arthritis 44.78 18.61 125 17149 299488 110272537
Rash vesicular 44.43 18.61 28 17246 14624 110557401
Synovitis 43.60 18.61 117 17157 273975 110298050
Sleep disorder 43.58 18.61 96 17178 198548 110373477
Ill-defined disorder 42.87 18.61 83 17191 156770 110415255
Hypercholesterolaemia 42.22 18.61 61 17213 90776 110481249
Folliculitis 41.37 18.61 85 17189 167568 110404457
Breast cancer stage II 40.80 18.61 34 17240 27341 110544684
Alveolar osteitis 39.29 18.61 12 17262 1073 110570952
Adjustment disorder with depressed mood 39.22 18.61 41 17233 43842 110528183
Swelling 38.09 18.61 131 17143 350910 110221115
Amaurosis fugax 37.12 18.61 14 17260 2376 110569649
Gait inability 37.06 18.61 72 17202 136304 110435721
Grip strength decreased 36.03 18.61 53 17221 80121 110491904
Facet joint syndrome 35.14 18.61 58 17216 96770 110475255
Anaemia 35.10 18.61 21 17253 547065 110024960
Neutropenia 34.67 18.61 8 17266 374612 110197413
Duodenal ulcer perforation 33.59 18.61 81 17193 177619 110394406
Febrile neutropenia 33.08 18.61 5 17269 316762 110255263
Animal scratch 32.95 18.61 12 17262 1847 110570178
Tunnel vision 32.01 18.61 12 17262 2003 110570022
Joint range of motion decreased 31.50 18.61 63 17211 121769 110450256
Hand deformity 31.49 18.61 90 17184 218416 110353609
Back disorder 31.21 18.61 26 17248 20896 110551129
Thymoma 30.42 18.61 8 17266 416 110571609
Maternal exposure during pregnancy 29.29 18.61 97 17177 254786 110317239
Migraine 29.03 18.61 75 17199 171577 110400448
Ear congestion 28.17 18.61 13 17261 3652 110568373
Bladder pain 28.16 18.61 12 17262 2793 110569232
X-ray abnormal 27.79 18.61 32 17242 38085 110533940
Thrombocytopenia 27.60 18.61 10 17264 348875 110223150
Dislocation of vertebra 27.43 18.61 34 17240 43687 110528338
Irritable bowel syndrome 27.00 18.61 71 17203 164144 110407881
Calculus urinary 26.82 18.61 12 17262 3140 110568885
C-reactive protein abnormal 26.55 18.61 61 17213 129634 110442391
Helicobacter infection 26.28 18.61 75 17199 181802 110390223
Hypotension 26.11 18.61 26 17248 523823 110048202
Lipoedema 24.27 18.61 6 17268 243 110571782
Blepharospasm 24.27 18.61 36 17238 54815 110517210
Swollen joint count increased 23.74 18.61 45 17229 83616 110488409
Respiratory failure 23.41 18.61 3 17271 215329 110356696
Muscle injury 23.26 18.61 61 17213 140746 110431279
Wound secretion 22.98 18.61 14 17260 6887 110565138
Dry mouth 22.88 18.61 76 17198 199872 110372153
Liver injury 22.68 18.61 63 17211 150350 110421675
Ocular discomfort 22.65 18.61 15 17259 8518 110563507
Urinary tract disorder 22.45 18.61 13 17261 5831 110566194
Vascular injury 22.41 18.61 8 17266 1163 110570862
Urticaria 21.73 18.61 103 17171 318754 110253271
Finger deformity 21.18 18.61 26 17248 33066 110538959
Impaired healing 20.95 18.61 73 17201 196644 110375381
Injury 20.83 18.61 68 17206 177197 110394828
Wheezing 20.82 18.61 87 17187 255143 110316882
Myositis 20.82 18.61 25 17249 31091 110540934
Live birth 20.49 18.61 38 17236 69446 110502579
Relapsing multiple sclerosis 19.96 18.61 5 17269 214 110571811
Depression 19.83 18.61 100 17174 317235 110254790
Sleep disorder due to general medical condition, insomnia type 19.78 18.61 48 17226 105595 110466430
Sinus pain 19.76 18.61 12 17262 5867 110566158
Infected lymphocele 19.32 18.61 5 17269 244 110571781
Lip dry 19.31 18.61 46 17228 100037 110471988
Disease progression 19.28 18.61 7 17267 244027 110327998
Wound complication 19.22 18.61 12 17262 6165 110565860
Vulval cancer 19.06 18.61 6 17268 593 110571432
Infusion related reaction 19.03 18.61 113 17161 381049 110190976
Paranasal sinus discomfort 18.82 18.61 12 17262 6393 110565632
Polymyalgia rheumatica 18.75 18.61 12 17262 6430 110565595
Pulmonary fibrosis 18.72 18.61 46 17228 101996 110470029

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D08AG03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D014131 Trace Elements
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Related Drugs by ATC class:

D08AG Iodine products 2 drugs
diiodohydroxypropanepovidone-iodine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Provision of therapeutic radionuclide indication 74385000
CD20 Positive Non-Hodgkin's Lymphoma indication
Neonatal thyrotoxicosis off-label use 13795004 DOID:12573
Thyrotoxic crisis off-label use 29028009 DOID:12837
Hyperthyroidism off-label use 34486009 DOID:7998
Lymphocutaneous sporotrichosis off-label use 87603003
Iodine deficiency off-label use 238121000
Thyroid Surgery off-label use
Thyroid Gland Radiation Protection off-label use
Bacterial septicemia contraindication 10001005 DOID:0040085
Hashimoto thyroiditis contraindication 21983002
Shock contraindication 27942005
Bronchitis contraindication 32398004 DOID:6132
Hypothyroidism contraindication 40930008 DOID:1459
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Pulmonary tuberculosis contraindication 154283005 DOID:2957
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004
Human Anti-Mouse Antibody (HAMA) Positive contraindication
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00108 KEGG_DRUG
4017659 VUID
N0000146037 NUI
4017659 VANDF
CHEBI:17606 CHEBI
CHEMBL1201225 ChEMBL_ID
DB05382 DRUGBANK_ID
9679TC07X4 UNII
807 PUBCHEM_CID
5933 RXNORM
4900 MMSL
d05776 MMSL
000852 NDDF
003150 NDDF
007599 NDDF
44588005 SNOMEDCT_US
767115003 SNOMEDCT_US
C0021968 UMLSCUI
D007455 MESH_DESCRIPTOR_UI
I2I PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Iodine HUMAN OTC DRUG LABEL 1 0363-0088 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-1213 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 0395-9118 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 200 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 0.15 mg ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 150 ug ORAL UNAPPROVED DRUG OTHER 6 sections
LUGOLS SOLUTION HUMAN PRESCRIPTION DRUG LABEL 1 10481-0111 LIQUID 0.40 g TOPICAL unapproved drug other 5 sections
Iodine HUMAN OTC DRUG LABEL 1 11344-880 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
IODINE HUMAN OTC DRUG LABEL 2 16638-166 SOLUTION 0.50 g TOPICAL OTC monograph not final 9 sections
De La Cruz Tincture of Iodine HUMAN OTC DRUG LABEL 3 24286-1528 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
GNP Idoinde Tincture 2% Mild HUMAN OTC DRUG LABEL 3 24385-213 LIQUID 20 mg TOPICAL OTC Monograph Drug 14 sections
Iodine Tincture HUMAN OTC DRUG LABEL 1 30142-088 SOLUTION/ DROPS 20 mg TOPICAL OTC Monograph Drug 13 sections
Iodine HUMAN OTC DRUG LABEL 1 41163-088 LIQUID 20 mg TOPICAL OTC Monograph Drug 12 sections
Strong Iodine Solution HUMAN PRESCRIPTION DRUG LABEL 2 48433-230 SOLUTION/ DROPS 700 mg ORAL unapproved drug other 11 sections
Sunmark Iodine HUMAN OTC DRUG LABEL 3 49348-133 TINCTURE 20 mg TOPICAL OTC Monograph Drug 7 sections
DDM Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 53943-213 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
Lugols Strong Iodine HUMAN PRESCRIPTION DRUG LABEL 2 59365-6064 SOLUTION 0.05 g TOPICAL UNAPPROVED DRUG OTHER 10 sections
mild iodine tincture HUMAN OTC DRUG LABEL 3 59450-030 LIQUID 20 mg TOPICAL OTC Monograph Drug 14 sections
Health Mart Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 62011-0117 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
Quality Choice Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 63868-330 LIQUID 20 mg TOPICAL OTC Monograph Drug 13 sections
Premier Value Iodine Tincture Mild HUMAN OTC DRUG LABEL 3 68016-121 LIQUID 20 mg TOPICAL OTC monograph not final 13 sections
COLLOIDAL IODINEINJECTION HUMAN OTC DRUG LABEL 1 69164-0001 SOLUTION 2 g SUBCUTANEOUS unapproved drug other 6 sections
Colloidal Iodine Solution HUMAN OTC DRUG LABEL 1 69164-0003 SOLUTION 2 g ORAL unapproved drug other 6 sections
Colloidal Iodine HUMAN OTC DRUG LABEL 1 69164-2001 SOLUTION 2 g TOPICAL OTC monograph not final 8 sections
JCI MN Colloidal Iodine Immune-improving Water HUMAN OTC DRUG LABEL 1 69164-2002 SOLUTION 2 g TOPICAL OTC monograph not final 8 sections
JCI MN Colloidal Iodine Immune-improving Water HUMAN OTC DRUG LABEL 1 69164-2002 SOLUTION 2 g TOPICAL OTC monograph not final 8 sections
Colloidal Iodine Ophthalmic HUMAN OTC DRUG LABEL 1 69164-3001 SOLUTION 0.10 g TOPICAL OTC monograph not final 8 sections
JCI MN Colloidal Iodine Eye Wash Cleansing Water (Quasi Drug) HUMAN OTC DRUG LABEL 1 69164-3002 SOLUTION 0.10 g TOPICAL OTC monograph not final 8 sections
JCI MN Colloidal Iodine Immune-improving Water HUMAN OTC DRUG LABEL 1 69164-4001 SOLUTION 2 g TOPICAL OTC monograph not final 8 sections