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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4343 | 4468-02-4 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted
|
None
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sedation complication | 517.86 | 11.32 | 212 | 37369 | 16732 | 90574134 |
| Creatinine renal clearance decreased | 505.45 | 11.32 | 215 | 37366 | 18684 | 90572182 |
| Blood calcium decreased | 429.51 | 11.32 | 222 | 37359 | 29960 | 90560906 |
| Orthostatic hypotension | 356.77 | 11.32 | 220 | 37361 | 41607 | 90549259 |
| Sedation | 330.73 | 11.32 | 221 | 37360 | 47950 | 90542916 |
| Cognitive disorder | 294.15 | 11.32 | 238 | 37343 | 69169 | 90521697 |
| Balance disorder | 265.91 | 11.32 | 260 | 37321 | 96820 | 90494046 |
| Depressed level of consciousness | 255.67 | 11.32 | 224 | 37357 | 72560 | 90518306 |
| Mobility decreased | 171.14 | 11.32 | 343 | 37238 | 250391 | 90340475 |
| Constipation | 154.93 | 11.32 | 352 | 37229 | 280043 | 90310823 |
| Amyloid arthropathy | 114.68 | 11.32 | 38 | 37543 | 1642 | 90589224 |
| Fall | 106.36 | 11.32 | 438 | 37143 | 481372 | 90109494 |
| Pulmonary pain | 97.69 | 11.32 | 46 | 37535 | 5068 | 90585798 |
| COVID-19 | 86.57 | 11.32 | 206 | 37375 | 168637 | 90422229 |
| Renal function test abnormal | 82.87 | 11.32 | 46 | 37535 | 7145 | 90583721 |
| Creatinine renal clearance increased | 76.80 | 11.32 | 34 | 37547 | 3247 | 90587619 |
| Product label confusion | 65.86 | 11.32 | 63 | 37518 | 22787 | 90568079 |
| Multiple drug therapy | 57.52 | 11.32 | 36 | 37545 | 6973 | 90583893 |
| Onychomycosis | 57.23 | 11.32 | 74 | 37507 | 37302 | 90553564 |
| Hypotension | 53.86 | 11.32 | 272 | 37309 | 325125 | 90265741 |
| Finger deformity | 50.16 | 11.32 | 65 | 37516 | 32832 | 90558034 |
| Pain | 43.35 | 11.32 | 615 | 36966 | 995726 | 89595140 |
| Copper deficiency | 42.60 | 11.32 | 10 | 37571 | 116 | 90590750 |
| Anosmia | 40.05 | 11.32 | 33 | 37548 | 9815 | 90581051 |
| Drug ineffective | 39.91 | 11.32 | 375 | 37206 | 1383923 | 89206943 |
| Rheumatoid factor positive | 39.69 | 11.32 | 11 | 37570 | 171639 | 90419227 |
| Necrosis ischaemic | 39.32 | 11.32 | 15 | 37566 | 980 | 90589886 |
| Taste disorder | 39.28 | 11.32 | 82 | 37499 | 61464 | 90529402 |
| Toxicity to various agents | 38.43 | 11.32 | 227 | 37354 | 287619 | 90303247 |
| Adverse reaction | 36.67 | 11.32 | 53 | 37528 | 29659 | 90561207 |
| Salpingo-oophorectomy unilateral | 36.13 | 11.32 | 14 | 37567 | 954 | 90589912 |
| Product dose omission issue | 35.75 | 11.32 | 225 | 37356 | 291462 | 90299404 |
| Acute kidney injury | 35.08 | 11.32 | 49 | 37532 | 320338 | 90270528 |
| Neck pain | 34.59 | 11.32 | 115 | 37466 | 113848 | 90477018 |
| Product use in unapproved indication | 34.40 | 11.32 | 248 | 37333 | 335988 | 90254878 |
| Sleep disorder due to general medical condition, insomnia type | 34.28 | 11.32 | 6 | 37575 | 128688 | 90462178 |
| Contraindicated product administered | 34.02 | 11.32 | 50 | 37531 | 320089 | 90270777 |
| Illness | 32.65 | 11.32 | 91 | 37490 | 81878 | 90508988 |
| Osteoarthritis | 32.61 | 11.32 | 164 | 37417 | 195566 | 90395300 |
| Obesity | 32.50 | 11.32 | 107 | 37474 | 105400 | 90485466 |
| Dermatitis atopic | 32.13 | 11.32 | 44 | 37537 | 23428 | 90567438 |
| Death | 31.78 | 11.32 | 91 | 37490 | 456460 | 90134406 |
| Carbuncle | 30.80 | 11.32 | 14 | 37567 | 1422 | 90589444 |
| Skin odour abnormal | 30.48 | 11.32 | 15 | 37566 | 1820 | 90589046 |
| Onychomadesis | 30.19 | 11.32 | 62 | 37519 | 45936 | 90544930 |
| Wound secretion | 29.74 | 11.32 | 21 | 37560 | 4969 | 90585897 |
| Sinusitis fungal | 29.52 | 11.32 | 15 | 37566 | 1949 | 90588917 |
| Discomfort | 28.99 | 11.32 | 43 | 37538 | 274292 | 90316574 |
| Muscle spasms | 28.83 | 11.32 | 191 | 37390 | 251692 | 90339174 |
| Beta haemolytic streptococcal infection | 28.71 | 11.32 | 16 | 37565 | 2503 | 90588363 |
| Monoclonal immunoglobulin present | 28.41 | 11.32 | 15 | 37566 | 2109 | 90588757 |
| Pneumonia streptococcal | 28.30 | 11.32 | 15 | 37566 | 2126 | 90588740 |
| Nail disorder | 28.03 | 11.32 | 70 | 37511 | 58997 | 90531869 |
| Drug abuse | 27.62 | 11.32 | 86 | 37495 | 82261 | 90508605 |
| Congenital anomaly | 27.35 | 11.32 | 22 | 37559 | 6325 | 90584541 |
| Back injury | 27.31 | 11.32 | 60 | 37521 | 46562 | 90544304 |
| Glossodynia | 26.36 | 11.32 | 59 | 37522 | 321720 | 90269146 |
| Pemphigus | 25.12 | 11.32 | 62 | 37519 | 326802 | 90264064 |
| Hypothalamo-pituitary disorder | 24.84 | 11.32 | 14 | 37567 | 2238 | 90588628 |
| Aplastic anaemia | 24.71 | 11.32 | 29 | 37552 | 13240 | 90577626 |
| Lipoedema | 24.25 | 11.32 | 8 | 37573 | 341 | 90590525 |
| Nasal polyps | 24.06 | 11.32 | 26 | 37555 | 10854 | 90580012 |
| Sinus pain | 23.91 | 11.32 | 19 | 37562 | 5370 | 90585496 |
| Sputum increased | 23.79 | 11.32 | 15 | 37566 | 2942 | 90587924 |
| Cardiac arrest | 23.74 | 11.32 | 7 | 37574 | 104928 | 90485938 |
| Intentional overdose | 23.67 | 11.32 | 5 | 37576 | 93829 | 90497037 |
| Overdose | 23.41 | 11.32 | 128 | 37453 | 157581 | 90433285 |
| Pyrexia | 22.95 | 11.32 | 170 | 37411 | 660315 | 89930551 |
| Thrombocytopenia | 22.75 | 11.32 | 32 | 37549 | 208693 | 90382173 |
| Hand deformity | 22.16 | 11.32 | 57 | 37524 | 296305 | 90294561 |
| Suicide attempt | 21.25 | 11.32 | 3 | 37578 | 75396 | 90515470 |
| Pulmonary fibrosis | 21.20 | 11.32 | 9 | 37572 | 107494 | 90483372 |
| Embolism venous | 21.03 | 11.32 | 15 | 37566 | 3605 | 90587261 |
| Spinal cord disorder | 20.78 | 11.32 | 11 | 37570 | 1554 | 90589312 |
| Acquired diaphragmatic eventration | 20.58 | 11.32 | 8 | 37573 | 550 | 90590316 |
| Swollen joint count increased | 19.37 | 11.32 | 11 | 37570 | 111195 | 90479671 |
| Infrapatellar fat pad inflammation | 18.92 | 11.32 | 6 | 37575 | 225 | 90590641 |
| Respiratory symptom | 18.88 | 11.32 | 15 | 37566 | 4237 | 90586629 |
| Diastolic dysfunction | 18.86 | 11.32 | 19 | 37562 | 7314 | 90583552 |
| Blepharospasm | 18.68 | 11.32 | 58 | 37523 | 55387 | 90535479 |
| Fistula discharge | 18.49 | 11.32 | 9 | 37572 | 1066 | 90589800 |
| Overweight | 18.32 | 11.32 | 17 | 37564 | 5917 | 90584949 |
| Migraine | 18.06 | 11.32 | 138 | 37443 | 190254 | 90400612 |
| Coma | 18.05 | 11.32 | 4 | 37577 | 72628 | 90518238 |
| Product use issue | 18.01 | 11.32 | 73 | 37508 | 329846 | 90261020 |
| Systemic lupus erythematosus | 17.97 | 11.32 | 83 | 37498 | 361813 | 90229053 |
| Wrist deformity | 17.86 | 11.32 | 13 | 37568 | 3225 | 90587641 |
| Rhinocerebral mucormycosis | 17.68 | 11.32 | 8 | 37573 | 804 | 90590062 |
| Arthritis infective | 17.50 | 11.32 | 19 | 37562 | 7973 | 90582893 |
| Product quality issue | 17.32 | 11.32 | 72 | 37509 | 79253 | 90511613 |
| Coeliac disease | 17.24 | 11.32 | 49 | 37532 | 44561 | 90546305 |
| Memory impairment | 17.08 | 11.32 | 140 | 37441 | 197104 | 90393762 |
| Gastrointestinal candidiasis | 17.06 | 11.32 | 6 | 37575 | 311 | 90590555 |
| Heart rate variability increased | 16.91 | 11.32 | 4 | 37577 | 48 | 90590818 |
| Limb injury | 16.72 | 11.32 | 39 | 37542 | 31469 | 90559397 |
| Endometrial cancer | 16.59 | 11.32 | 13 | 37568 | 3599 | 90587267 |
| Procedural complication | 16.55 | 11.32 | 16 | 37565 | 5862 | 90585004 |
| Vertebral lateral recess stenosis | 16.44 | 11.32 | 6 | 37575 | 346 | 90590520 |
| Fibrosis | 16.38 | 11.32 | 16 | 37565 | 5936 | 90584930 |
| Neutropenia | 16.24 | 11.32 | 44 | 37537 | 224860 | 90366006 |
| Dry skin | 16.24 | 11.32 | 76 | 37505 | 87997 | 90502869 |
| Osteoarthropathy | 16.18 | 11.32 | 6 | 37575 | 362 | 90590504 |
| Ageusia | 16.06 | 11.32 | 26 | 37555 | 16050 | 90574816 |
| Ligamentum flavum hypertrophy | 16.04 | 11.32 | 6 | 37575 | 371 | 90590495 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 15.75 | 11.32 | 8 | 37573 | 1039 | 90589827 |
| Liver function test increased | 15.48 | 11.32 | 73 | 37508 | 84782 | 90506084 |
| Product administration error | 15.47 | 11.32 | 34 | 37547 | 26389 | 90564477 |
| Hypokalaemia | 15.41 | 11.32 | 19 | 37562 | 131097 | 90459769 |
| Yellow skin | 15.33 | 11.32 | 11 | 37570 | 2670 | 90588196 |
| Product dose omission in error | 15.09 | 11.32 | 29 | 37552 | 20474 | 90570392 |
| Incorrect product administration duration | 15.05 | 11.32 | 28 | 37553 | 19294 | 90571572 |
| Eczema | 14.85 | 11.32 | 52 | 37529 | 52818 | 90538048 |
| Abnormal faeces | 14.83 | 11.32 | 16 | 37565 | 6666 | 90584200 |
| Sneezing | 14.80 | 11.32 | 36 | 37545 | 29833 | 90561033 |
| Terminal insomnia | 14.62 | 11.32 | 8 | 37573 | 1207 | 90589659 |
| Bladder disorder | 14.45 | 11.32 | 20 | 37561 | 10752 | 90580114 |
| Blood smear test abnormal | 14.44 | 11.32 | 4 | 37577 | 93 | 90590773 |
| Anti-cyclic citrullinated peptide antibody positive | 14.40 | 11.32 | 50 | 37531 | 236383 | 90354483 |
| Eyelid margin crusting | 14.28 | 11.32 | 9 | 37572 | 1763 | 90589103 |
| Rheumatoid arthritis | 14.22 | 11.32 | 90 | 37491 | 362524 | 90228342 |
| Hip arthroplasty | 14.06 | 11.32 | 7 | 37574 | 76201 | 90514665 |
| Prescribed overdose | 13.90 | 11.32 | 12 | 37569 | 97613 | 90493253 |
| Injection site pain | 13.83 | 11.32 | 121 | 37460 | 173578 | 90417288 |
| Peripheral venous disease | 13.74 | 11.32 | 70 | 37511 | 83851 | 90507015 |
| Chondropathy | 13.66 | 11.32 | 10 | 37571 | 2502 | 90588364 |
| Tachycardia | 13.66 | 11.32 | 28 | 37553 | 157645 | 90433221 |
| Infusion related reaction | 13.64 | 11.32 | 109 | 37472 | 416671 | 90174195 |
| Hyperkalaemia | 13.52 | 11.32 | 5 | 37576 | 64959 | 90525907 |
| Angioedema | 13.50 | 11.32 | 5 | 37576 | 64871 | 90525995 |
| Duodenal ulcer perforation | 13.34 | 11.32 | 47 | 37534 | 221241 | 90369625 |
| Hysterectomy | 13.33 | 11.32 | 20 | 37561 | 11564 | 90579302 |
| Cough | 13.33 | 11.32 | 221 | 37360 | 368741 | 90222125 |
| Gastrooesophageal reflux disease | 13.31 | 11.32 | 116 | 37465 | 166221 | 90424645 |
| Bladder spasm | 13.17 | 11.32 | 9 | 37572 | 2021 | 90588845 |
| Abdominal distension | 13.14 | 11.32 | 96 | 37485 | 130505 | 90460361 |
| Hyponatraemia | 13.08 | 11.32 | 22 | 37559 | 133516 | 90457350 |
| Effusion | 13.04 | 11.32 | 9 | 37572 | 2053 | 90588813 |
| Body height decreased | 12.87 | 11.32 | 20 | 37561 | 11929 | 90578937 |
| Electrocardiogram QT prolonged | 12.86 | 11.32 | 7 | 37574 | 72449 | 90518417 |
| Candida infection | 12.77 | 11.32 | 37 | 37544 | 34020 | 90556846 |
| Osmophobia | 12.69 | 11.32 | 4 | 37577 | 147 | 90590719 |
| Antiacetylcholine receptor antibody positive | 12.64 | 11.32 | 4 | 37577 | 149 | 90590717 |
| Emphysema | 12.61 | 11.32 | 20 | 37561 | 12135 | 90578731 |
| Pregnancy | 12.54 | 11.32 | 5 | 37576 | 62042 | 90528824 |
| Feeling abnormal | 12.54 | 11.32 | 115 | 37466 | 167120 | 90423746 |
| General physical health deterioration | 12.50 | 11.32 | 91 | 37490 | 355024 | 90235842 |
| Disease recurrence | 12.32 | 11.32 | 39 | 37542 | 37614 | 90553252 |
| Lack of infusion site rotation | 12.30 | 11.32 | 4 | 37577 | 163 | 90590703 |
| Pericarditis | 12.23 | 11.32 | 64 | 37517 | 270087 | 90320779 |
| Inappropriate schedule of product administration | 12.22 | 11.32 | 105 | 37476 | 149828 | 90441038 |
| Calcitonin secretion disorder | 12.19 | 11.32 | 3 | 37578 | 43 | 90590823 |
| Skin disorder | 12.00 | 11.32 | 38 | 37543 | 36668 | 90554198 |
| Spleen atrophy | 11.89 | 11.32 | 3 | 37578 | 48 | 90590818 |
| Haemorrhagic diathesis | 11.86 | 11.32 | 13 | 37568 | 5511 | 90585355 |
| Underdose | 11.77 | 11.32 | 49 | 37532 | 53968 | 90536898 |
| Infection | 11.70 | 11.32 | 95 | 37486 | 361999 | 90228867 |
| Wound complication | 11.63 | 11.32 | 12 | 37569 | 4751 | 90586115 |
| Scar | 11.61 | 11.32 | 22 | 37559 | 15373 | 90575493 |
| Norovirus infection | 11.55 | 11.32 | 8 | 37573 | 1836 | 90589030 |
| Abortion spontaneous | 11.53 | 11.32 | 4 | 37577 | 54052 | 90536814 |
| Ocular icterus | 11.52 | 11.32 | 11 | 37570 | 3969 | 90586897 |
| Skin warm | 11.42 | 11.32 | 15 | 37566 | 7672 | 90583194 |
| Myelosuppression | 11.37 | 11.32 | 4 | 37577 | 53587 | 90537279 |
| Blood uric acid decreased | 11.34 | 11.32 | 6 | 37575 | 847 | 90590019 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Radiation inflammation | 57.21 | 14.43 | 18 | 11386 | 1030 | 42608901 |
| Pulmonary pain | 53.76 | 14.43 | 19 | 11385 | 1559 | 42608372 |
| Rhinocerebral mucormycosis | 46.79 | 14.43 | 14 | 11390 | 676 | 42609255 |
| Off label use | 45.85 | 14.43 | 309 | 11095 | 638026 | 41971905 |
| Copper deficiency | 40.18 | 14.43 | 7 | 11397 | 24 | 42609907 |
| COVID-19 | 37.03 | 14.43 | 90 | 11314 | 115858 | 42494073 |
| Genital pain | 35.02 | 14.43 | 12 | 11392 | 898 | 42609033 |
| Genital ulceration | 31.39 | 14.43 | 11 | 11393 | 880 | 42609051 |
| Toxicity to various agents | 28.25 | 14.43 | 13 | 11391 | 229123 | 42380808 |
| Fatigue | 27.65 | 14.43 | 205 | 11199 | 435436 | 42174495 |
| Product dose omission issue | 27.26 | 14.43 | 97 | 11307 | 154268 | 42455663 |
| Anosmia | 27.02 | 14.43 | 17 | 11387 | 5159 | 42604772 |
| Irritable bowel syndrome | 23.51 | 14.43 | 15 | 11389 | 4666 | 42605265 |
| Food poisoning | 22.42 | 14.43 | 12 | 11392 | 2694 | 42607237 |
| Injection site pain | 21.88 | 14.43 | 48 | 11356 | 57750 | 42552181 |
| Dermatitis atopic | 21.08 | 14.43 | 21 | 11383 | 12383 | 42597548 |
| Illness | 20.31 | 14.43 | 29 | 11375 | 24901 | 42585030 |
| Gastrointestinal pain | 19.37 | 14.43 | 13 | 11391 | 4402 | 42605529 |
| Arthropathy | 19.25 | 14.43 | 31 | 11373 | 29566 | 42580365 |
| Vascular device infection | 17.71 | 14.43 | 14 | 11390 | 6096 | 42603835 |
| Aplastic anaemia | 17.51 | 14.43 | 19 | 11385 | 12365 | 42597566 |
| Lung neoplasm malignant | 16.68 | 14.43 | 23 | 11381 | 19124 | 42590807 |
| Schizophrenia | 16.36 | 14.43 | 17 | 11387 | 10533 | 42599398 |
| Metal poisoning | 16.22 | 14.43 | 4 | 11400 | 92 | 42609839 |
| Knee arthroplasty | 15.16 | 14.43 | 15 | 11389 | 8766 | 42601165 |
| Intentional product misuse | 14.62 | 14.43 | 43 | 11361 | 61857 | 42548074 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sedation complication | 512.60 | 11.54 | 215 | 41943 | 19640 | 110527501 |
| Creatinine renal clearance decreased | 502.89 | 11.54 | 218 | 41940 | 21597 | 110525544 |
| Blood calcium decreased | 425.11 | 11.54 | 227 | 41931 | 35618 | 110511523 |
| Orthostatic hypotension | 297.21 | 11.54 | 227 | 41931 | 66022 | 110481119 |
| Sedation | 280.62 | 11.54 | 224 | 41934 | 69459 | 110477682 |
| Cognitive disorder | 277.40 | 11.54 | 245 | 41913 | 87266 | 110459875 |
| Balance disorder | 244.32 | 11.54 | 260 | 41898 | 116300 | 110430841 |
| Mobility decreased | 201.24 | 11.54 | 340 | 41818 | 237082 | 110310059 |
| Depressed level of consciousness | 193.26 | 11.54 | 226 | 41932 | 112052 | 110435089 |
| Pulmonary pain | 151.90 | 11.54 | 65 | 42093 | 6228 | 110540913 |
| Constipation | 145.43 | 11.54 | 379 | 41779 | 357407 | 110189734 |
| Amyloid arthropathy | 117.82 | 11.54 | 38 | 42120 | 1642 | 110545499 |
| COVID-19 | 102.98 | 11.54 | 263 | 41895 | 244797 | 110302344 |
| Fall | 79.87 | 11.54 | 446 | 41712 | 603036 | 109944105 |
| Completed suicide | 79.21 | 11.54 | 3 | 42155 | 242378 | 110304763 |
| Renal function test abnormal | 77.12 | 11.54 | 46 | 42112 | 8900 | 110538241 |
| Creatinine renal clearance increased | 76.29 | 11.54 | 34 | 42124 | 3591 | 110543550 |
| Copper deficiency | 75.60 | 11.54 | 17 | 42141 | 176 | 110546965 |
| Product label confusion | 70.81 | 11.54 | 63 | 42095 | 22614 | 110524527 |
| Pain | 70.17 | 11.54 | 611 | 41547 | 954344 | 109592797 |
| Onychomycosis | 62.01 | 11.54 | 75 | 42083 | 38456 | 110508685 |
| Acute kidney injury | 61.44 | 11.54 | 92 | 42066 | 635338 | 109911803 |
| Rhinocerebral mucormycosis | 58.64 | 11.54 | 22 | 42136 | 1495 | 110545646 |
| Multiple drug therapy | 55.87 | 11.54 | 36 | 42122 | 7978 | 110539163 |
| Taste disorder | 54.43 | 11.54 | 93 | 42065 | 65294 | 110481847 |
| Anosmia | 54.27 | 11.54 | 42 | 42116 | 12430 | 110534711 |
| Finger deformity | 54.22 | 11.54 | 65 | 42093 | 33027 | 110514114 |
| Product dose omission issue | 52.30 | 11.54 | 252 | 41906 | 321530 | 110225611 |
| Radiation inflammation | 50.95 | 11.54 | 18 | 42140 | 1030 | 110546111 |
| Adverse reaction | 40.30 | 11.54 | 53 | 42105 | 29541 | 110517600 |
| Salpingo-oophorectomy unilateral | 39.36 | 11.54 | 14 | 42144 | 817 | 110546324 |
| Drug ineffective | 37.99 | 11.54 | 384 | 41774 | 1520156 | 109026985 |
| Obesity | 36.05 | 11.54 | 110 | 42048 | 113241 | 110433900 |
| Necrosis ischaemic | 36.01 | 11.54 | 15 | 42143 | 1344 | 110545797 |
| Illness | 35.30 | 11.54 | 89 | 42069 | 82082 | 110465059 |
| Osteoarthritis | 33.31 | 11.54 | 148 | 42010 | 182475 | 110364666 |
| Onychomadesis | 32.92 | 11.54 | 61 | 42097 | 45602 | 110501539 |
| Aplastic anaemia | 32.28 | 11.54 | 43 | 42115 | 24265 | 110522876 |
| Intentional overdose | 31.75 | 11.54 | 6 | 42152 | 132495 | 110414646 |
| Carbuncle | 31.65 | 11.54 | 14 | 42144 | 1453 | 110545688 |
| Coma | 31.28 | 11.54 | 4 | 42154 | 117865 | 110429276 |
| Nasal polyps | 30.40 | 11.54 | 31 | 42127 | 13169 | 110533972 |
| Skin odour abnormal | 30.37 | 11.54 | 16 | 42142 | 2438 | 110544703 |
| Neck pain | 29.82 | 11.54 | 109 | 42049 | 123021 | 110424120 |
| Nail disorder | 29.46 | 11.54 | 67 | 42091 | 57868 | 110489273 |
| Neutropenia | 29.16 | 11.54 | 62 | 42096 | 374558 | 110172583 |
| Back injury | 28.91 | 11.54 | 59 | 42099 | 47340 | 110499801 |
| Off label use | 27.86 | 11.54 | 758 | 41400 | 1499427 | 109047714 |
| Dermatitis atopic | 27.69 | 11.54 | 41 | 42117 | 25500 | 110521641 |
| Rheumatoid factor positive | 27.51 | 11.54 | 8 | 42150 | 131632 | 110415509 |
| Monoclonal immunoglobulin present | 27.08 | 11.54 | 15 | 42143 | 2525 | 110544616 |
| Sleep disorder due to general medical condition, insomnia type | 27.05 | 11.54 | 4 | 42154 | 105639 | 110441502 |
| Lower respiratory tract infection | 26.50 | 11.54 | 171 | 41987 | 242935 | 110304206 |
| Sinusitis fungal | 26.12 | 11.54 | 15 | 42143 | 2705 | 110544436 |
| Genital pain | 25.89 | 11.54 | 12 | 42146 | 1388 | 110545753 |
| Hypotension | 25.73 | 11.54 | 309 | 41849 | 523540 | 110023601 |
| Memory impairment | 25.58 | 11.54 | 145 | 42013 | 196799 | 110350342 |
| Death | 25.49 | 11.54 | 159 | 41999 | 698710 | 109848431 |
| Hypothalamo-pituitary disorder | 25.49 | 11.54 | 15 | 42143 | 2831 | 110544310 |
| Thrombocytopenia | 25.30 | 11.54 | 60 | 42098 | 348825 | 110198316 |
| Beta haemolytic streptococcal infection | 24.89 | 11.54 | 15 | 42143 | 2956 | 110544185 |
| Cardiac failure | 24.82 | 11.54 | 21 | 42137 | 187605 | 110359536 |
| Suicide attempt | 24.11 | 11.54 | 5 | 42153 | 103389 | 110443752 |
| Muscle spasms | 24.08 | 11.54 | 185 | 41973 | 277972 | 110269169 |
| Migraine | 24.04 | 11.54 | 129 | 42029 | 171523 | 110375618 |
| Sinus pain | 23.86 | 11.54 | 19 | 42139 | 5860 | 110541281 |
| Agitation | 23.39 | 11.54 | 7 | 42151 | 113044 | 110434097 |
| Pneumonia streptococcal | 22.68 | 11.54 | 15 | 42143 | 3474 | 110543667 |
| Blepharospasm | 22.10 | 11.54 | 58 | 42100 | 54793 | 110492348 |
| Acquired diaphragmatic eventration | 21.97 | 11.54 | 9 | 42149 | 773 | 110546368 |
| Liver function test increased | 21.95 | 11.54 | 79 | 42079 | 88469 | 110458672 |
| Abdominal distension | 21.48 | 11.54 | 127 | 42031 | 174976 | 110372165 |
| Wound secretion | 21.20 | 11.54 | 19 | 42139 | 6882 | 110540259 |
| Pyrexia | 21.04 | 11.54 | 230 | 41928 | 898035 | 109649106 |
| Oral pain | 20.96 | 11.54 | 45 | 42113 | 37399 | 110509742 |
| Coeliac disease | 20.92 | 11.54 | 49 | 42109 | 43138 | 110504003 |
| Angioedema | 20.56 | 11.54 | 6 | 42152 | 98494 | 110448647 |
| Drug interaction | 20.24 | 11.54 | 110 | 42048 | 500073 | 110047068 |
| Product quality issue | 20.05 | 11.54 | 70 | 42088 | 77229 | 110469912 |
| Respiratory failure | 19.97 | 11.54 | 32 | 42126 | 215300 | 110331841 |
| Embolism venous | 19.89 | 11.54 | 16 | 42142 | 5007 | 110542134 |
| Incorrect product administration duration | 19.54 | 11.54 | 31 | 42127 | 20467 | 110526674 |
| Infrapatellar fat pad inflammation | 19.42 | 11.54 | 6 | 42152 | 225 | 110546916 |
| Genital ulceration | 19.25 | 11.54 | 11 | 42147 | 1964 | 110545177 |
| Myelosuppression | 19.23 | 11.54 | 6 | 42152 | 94334 | 110452807 |
| Wrist deformity | 19.02 | 11.54 | 13 | 42145 | 3176 | 110543965 |
| Lipoedema | 18.97 | 11.54 | 6 | 42152 | 243 | 110546898 |
| Overdose | 18.85 | 11.54 | 153 | 42005 | 233641 | 110313500 |
| Knee arthroplasty | 18.78 | 11.54 | 61 | 42097 | 64887 | 110482254 |
| Sputum increased | 18.00 | 11.54 | 16 | 42142 | 5735 | 110541406 |
| Peripheral venous disease | 17.52 | 11.54 | 71 | 42087 | 84046 | 110463095 |
| Gastrooesophageal reflux disease | 17.45 | 11.54 | 123 | 42035 | 179853 | 110367288 |
| Product use in unapproved indication | 17.41 | 11.54 | 253 | 41905 | 447124 | 110100017 |
| Heart rate variability increased | 17.25 | 11.54 | 4 | 42154 | 48 | 110547093 |
| Tachycardia | 17.21 | 11.54 | 38 | 42120 | 226607 | 110320534 |
| Drug reaction with eosinophilia and systemic symptoms | 17.13 | 11.54 | 5 | 42153 | 82090 | 110465051 |
| Lactic acidosis | 17.05 | 11.54 | 7 | 42151 | 92804 | 110454337 |
| Endometrial cancer | 16.96 | 11.54 | 11 | 42147 | 2465 | 110544676 |
| Hyponatraemia | 16.94 | 11.54 | 36 | 42122 | 217617 | 110329524 |
| Vertebral lateral recess stenosis | 16.94 | 11.54 | 6 | 42152 | 346 | 110546795 |
| Disease progression | 16.88 | 11.54 | 43 | 42115 | 243991 | 110303150 |
| Hysterectomy | 16.80 | 11.54 | 18 | 42140 | 8096 | 110539045 |
| Food poisoning | 16.59 | 11.54 | 16 | 42142 | 6356 | 110540785 |
| Ligamentum flavum hypertrophy | 16.57 | 11.54 | 6 | 42152 | 369 | 110546772 |
| Osteoarthropathy | 16.50 | 11.54 | 6 | 42152 | 373 | 110546768 |
| Limb injury | 16.41 | 11.54 | 41 | 42117 | 37595 | 110509546 |
| Overweight | 16.40 | 11.54 | 16 | 42142 | 6448 | 110540693 |
| Dry skin | 15.82 | 11.54 | 82 | 42076 | 107571 | 110439570 |
| Fistula discharge | 15.60 | 11.54 | 9 | 42149 | 1637 | 110545504 |
| Intentional product misuse | 15.41 | 11.54 | 95 | 42063 | 132809 | 110414332 |
| Bladder disorder | 15.25 | 11.54 | 20 | 42138 | 11117 | 110536024 |
| Hypokalaemia | 15.20 | 11.54 | 29 | 42129 | 182419 | 110364722 |
| Injection site pain | 15.20 | 11.54 | 118 | 42040 | 177804 | 110369337 |
| Sneezing | 15.18 | 11.54 | 36 | 42122 | 31948 | 110515193 |
| Leukopenia | 14.87 | 11.54 | 21 | 42137 | 148770 | 110398371 |
| Myocardial infarction | 14.76 | 11.54 | 32 | 42126 | 192051 | 110355090 |
| Arthritis infective | 14.70 | 11.54 | 19 | 42139 | 10410 | 110536731 |
| Electrocardiogram QT prolonged | 14.65 | 11.54 | 12 | 42146 | 108948 | 110438193 |
| Body height decreased | 14.51 | 11.54 | 19 | 42139 | 10544 | 110536597 |
| Gastrointestinal candidiasis | 14.44 | 11.54 | 6 | 42152 | 534 | 110546607 |
| Underdose | 14.33 | 11.54 | 55 | 42103 | 63499 | 110483642 |
| Genital herpes | 14.29 | 11.54 | 10 | 42148 | 2537 | 110544604 |
| Normal newborn | 14.24 | 11.54 | 28 | 42130 | 21868 | 110525273 |
| Fibrosis | 14.17 | 11.54 | 16 | 42142 | 7626 | 110539515 |
| Gastrointestinal haemorrhage | 14.06 | 11.54 | 26 | 42132 | 165492 | 110381649 |
| Feeling abnormal | 13.89 | 11.54 | 117 | 42041 | 180594 | 110366547 |
| Urinary tract discomfort | 13.89 | 11.54 | 7 | 42151 | 973 | 110546168 |
| Wound infection | 13.84 | 11.54 | 73 | 42085 | 96392 | 110450749 |
| Hyperkalaemia | 13.74 | 11.54 | 19 | 42139 | 135777 | 110411364 |
| Effusion | 13.58 | 11.54 | 10 | 42148 | 2747 | 110544394 |
| Blood testosterone abnormal | 13.44 | 11.54 | 5 | 42153 | 332 | 110546809 |
| Dementia | 13.28 | 11.54 | 34 | 42124 | 31639 | 110515502 |
| Osmophobia | 13.24 | 11.54 | 4 | 42154 | 139 | 110547002 |
| Discomfort | 13.23 | 11.54 | 40 | 42118 | 214667 | 110332474 |
| Respiratory arrest | 13.22 | 11.54 | 3 | 42155 | 58296 | 110488845 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | 13.22 | 11.54 | 9 | 42149 | 2186 | 110544955 |
| Spinal cord disorder | 13.21 | 11.54 | 9 | 42149 | 2189 | 110544952 |
| Chondropathy | 13.17 | 11.54 | 10 | 42148 | 2877 | 110544264 |
| Female genital tract fistula | 13.09 | 11.54 | 23 | 42135 | 16496 | 110530645 |
| Hypoglycaemia | 13.04 | 11.54 | 15 | 42143 | 116089 | 110431052 |
| Skin disorder | 13.04 | 11.54 | 41 | 42117 | 42872 | 110504269 |
| Swollen joint count increased | 12.84 | 11.54 | 8 | 42150 | 83653 | 110463488 |
| Lack of infusion site rotation | 12.75 | 11.54 | 4 | 42154 | 158 | 110546983 |
| Scar | 12.73 | 11.54 | 23 | 42135 | 16858 | 110530283 |
| Hepato-lenticular degeneration | 12.65 | 11.54 | 3 | 42155 | 40 | 110547101 |
| Ageusia | 12.63 | 11.54 | 25 | 42133 | 19620 | 110527521 |
| Drug resistance | 12.59 | 11.54 | 3 | 42155 | 56371 | 110490770 |
| Agranulocytosis | 12.46 | 11.54 | 4 | 42154 | 61756 | 110485385 |
| Calcitonin secretion disorder | 12.44 | 11.54 | 3 | 42155 | 43 | 110547098 |
| Diastolic dysfunction | 12.16 | 11.54 | 19 | 42139 | 12385 | 110534756 |
| Cardio-respiratory arrest | 11.93 | 11.54 | 16 | 42142 | 115820 | 110431321 |
| Terminal insomnia | 11.80 | 11.54 | 8 | 42150 | 1930 | 110545211 |
| Tenderness | 11.73 | 11.54 | 31 | 42127 | 29406 | 110517735 |
| Product administration error | 11.72 | 11.54 | 36 | 42122 | 37181 | 110509960 |
| Delirium | 11.66 | 11.54 | 21 | 42137 | 135004 | 110412137 |
| Haematemesis | 11.62 | 11.54 | 4 | 42154 | 59104 | 110488037 |
None
| Source | Code | Description |
|---|---|---|
| ATC | A12CB02 | ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Zinc |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ascorbic acid deficiency | indication | 76169001 | |
| Zinc deficiency | indication | 238124008 | |
| Hereditary acrodermatitis enteropathica | off-label use | 37702000 | |
| Methemoglobinemia | off-label use | 38959009 | DOID:10783 |
| Viral gastroenteritis | off-label use | 111843007 | |
| Cerebral trauma | off-label use | 275382005 | |
| Attention deficit hyperactivity disorder | off-label use | 406506008 | |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Hypocupremia | contraindication | 19577007 | |
| Multiple sclerosis | contraindication | 24700007 | DOID:2377 |
| Acute tuberculosis | contraindication | 25629007 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Allergic rhinitis | contraindication | 61582004 | |
| Diarrhea | contraindication | 62315008 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Rheumatoid arthritis | contraindication | 69896004 | DOID:7148 |
| Human immunodeficiency virus infection | contraindication | 86406008 | DOID:526 |
| Leukemia, disease | contraindication | 93143009 | DOID:1240 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Acute exacerbation of asthma | contraindication | 708038006 |
| Species | Use | Relation |
|---|---|---|
| Dogs | Chemical sterilization | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Zeuterin | Ark Sciences Inc. | 1 |
None
None
None
None
| ID | Source |
|---|---|
| 4020809 | VUID |
| N0000148330 | NUI |
| D02390 | KEGG_DRUG |
| 12389-19-4 | SECONDARY_CAS_RN |
| 4020507 | VANDF |
| 4020809 | VANDF |
| C0149381 | UMLSCUI |
| CHEBI:29708 | CHEBI |
| CHEMBL3833377 | ChEMBL_ID |
| DB11248 | DRUGBANK_ID |
| C030691 | MESH_SUPPLEMENTAL_RECORD_UI |
| U6WSN5SQ1Z | UNII |
| 443445 | PUBCHEM_CID |
| 1440975 | RXNORM |
| 34828 | MMSL |
| 5059 | MMSL |
| 5708 | MMSL |
| 72012 | MMSL |
| d04056 | MMSL |
| 000843 | NDDF |
| 001943 | NDDF |
| 111039007 | SNOMEDCT_US |
| 420444000 | SNOMEDCT_US |
| U6WSN5SQ1Z | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Floriva | HUMAN PRESCRIPTION DRUG LABEL | 16 | 52796-173 | TABLET, CHEWABLE | 5 mg | ORAL | UNAPPROVED DRUG OTHER | 6 sections |
| Floriva | HUMAN PRESCRIPTION DRUG LABEL | 16 | 52796-174 | TABLET, CHEWABLE | 5 mg | ORAL | UNAPPROVED DRUG OTHER | 6 sections |
| Floriva | HUMAN PRESCRIPTION DRUG LABEL | 16 | 52796-177 | TABLET, CHEWABLE | 5 mg | ORAL | UNAPPROVED DRUG OTHER | 7 sections |
| ZINC INJECTABLE A 1mg/ml, solution injectable pour perfusion | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60710-001 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | Unapproved drug for use in drug shortage | 2 sections |
| NBB | HUMAN OTC DRUG LABEL | 3 | 64762-862 | SPRAY, METERED | 12.42 mg | ORAL | OTC MONOGRAPH FINAL | 12 sections |
| NBE | HUMAN OTC DRUG LABEL | 2 | 64762-871 | SPRAY, METERED | 12.26 mg | ORAL | OTC MONOGRAPH FINAL | 12 sections |
| Zyvana | HUMAN PRESCRIPTION DRUG LABEL | 5 | 69336-405 | CAPSULE | 23 mg | ORAL | unapproved drug other | 8 sections |
| Dermamed Nutrition for troubled skin | HUMAN OTC DRUG LABEL | 7 | 69711-687 | CAPSULE, GELATIN COATED | 10 mg | ORAL | OTC monograph not final | 10 sections |
| Detangjiang | HUMAN OTC DRUG LABEL | 8 | 82570-018 | POWDER | 2 g | TOPICAL | unapproved drug other | 8 sections |
| ACNE FORMULA | HUMAN OTC DRUG LABEL | 5 | 83325-004 | CREAM | 0.50 g | TOPICAL | OTC Monograph Drug | 10 sections |