apixaban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
blood coagulation factor XA inhibitors, antithrombotics 4298 503612-47-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • apixaban
  • eliquis
  • BMS 562247
  • BMS-562247
  • BMS-562247-01
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.
  • Molecular weight: 459.51
  • Formula: C25H25N5O4
  • CLOGP: 1.99
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 110.76
  • ALOGS: -3.83
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.04 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.510 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 7.311 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 44.463 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.340 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 31.720 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 49.370 % High 1
herg hERG pIC50 4.500 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.042 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.381 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 28.240 % High 1
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MARK4,MET,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ULK1 42
kinase-selectivity-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,SIK2,STK33,TTK,ULK1 14
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.419 High 1
mh-clint Mouse hepatocyte intrinsic clearance 2.844 High 1
mppb Mouse plasma protein binding (% unbound) 17.220 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 34.277 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 40.610 % High 1
rh-clint Rat hepatocyte intrinsic clearance 2.158 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 81.400 % High 1
rppb Rat plasma protein binding (% unbound) 16.630 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 22.646 uM High 1

Approvals:

DateAgencyCompanyOrphan
May 18, 2011 EMA
Dec. 28, 2012 FDA BRISTOL MYERS SQUIBB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 2186.55 10.46 3621 185422 452930 89986474
Atrial fibrillation 1594.89 10.46 1665 187378 131946 90307458
Gastrointestinal haemorrhage 1430.80 10.46 1314 187729 88934 90350470
Cerebral haemorrhage 1015.50 10.46 722 188321 33800 90405604
Haemorrhage 909.56 10.46 910 188133 68459 90370945
Cerebrovascular accident 876.90 10.46 1181 187862 122352 90317052
Fall 789.20 10.46 2500 186543 479310 89960094
Thrombosis 733.74 10.46 833 188210 72418 90366986
Haemorrhage intracranial 719.04 10.46 428 188615 14734 90424670
Epistaxis 648.83 10.46 843 188200 84282 90355122
Pemphigus 648.62 10.46 6 189037 326858 90112546
Haematoma 628.90 10.46 574 188469 38474 90400930
Anaemia 614.20 10.46 1871 187172 350931 90088473
Synovitis 584.47 10.46 24 189019 329728 90109676
Hand deformity 567.92 10.46 10 189033 296352 90143052
Glossodynia 558.55 10.46 27 189016 321752 90117652
Subarachnoid haemorrhage 557.89 10.46 388 188655 17516 90421888
Drug ineffective 552.00 10.46 1306 187737 1382992 89056412
Cardiac failure 536.49 10.46 880 188163 108616 90330788
Infusion related reaction 525.28 10.46 114 188929 416666 90022738
Systemic lupus erythematosus 501.05 10.46 78 188965 361818 90077586
Pulmonary embolism 497.94 10.46 941 188102 129879 90309525
Subdural haematoma 493.70 10.46 350 188693 16295 90423109
Cardiac disorder 454.90 10.46 577 188466 56295 90383109
Melaena 449.48 10.46 453 188590 34344 90405060
Duodenal ulcer perforation 444.04 10.46 3 189040 221285 90218119
Maternal exposure during pregnancy 432.77 10.46 109 188934 359954 90079450
Exposure during pregnancy 430.40 10.46 15 189028 238395 90201009
Helicobacter infection 414.02 10.46 13 189030 226837 90212567
Ischaemic stroke 406.97 10.46 351 188692 21815 90417589
Rheumatoid arthritis 396.73 10.46 131 188912 362483 90076921
Folliculitis 395.15 10.46 6 189037 204347 90235057
Renal impairment 384.69 10.46 745 188298 104676 90334728
Hospitalisation 382.19 10.46 833 188210 127267 90312137
Joint swelling 381.88 10.46 295 188748 503005 89936399
Hepatic enzyme increased 376.34 10.46 141 188902 360595 90078809
Dyspnoea 372.04 10.46 3117 185926 877838 89561566
Drug hypersensitivity 369.49 10.46 258 188785 463351 89976053
Therapeutic product effect decreased 368.19 10.46 67 188976 277504 90161900
Drug intolerance 363.47 10.46 244 188799 447347 89992057
Impaired healing 341.55 10.46 43 189000 234156 90205248
Acute kidney injury 333.77 10.46 1438 187605 318949 90120455
Arthropathy 317.48 10.46 185 188858 366057 90073347
Psoriatic arthropathy 309.60 10.46 52 188991 228283 90211121
Hypotension 307.66 10.46 1419 187624 323978 90115426
Irritable bowel syndrome 305.14 10.46 37 189006 207411 90231993
Blood cholesterol increased 303.77 10.46 38 189005 207974 90231430
Contraindicated product administered 303.59 10.46 144 188899 319995 90119409
Wound 300.27 10.46 128 188915 302852 90136552
Shock haemorrhagic 288.02 10.46 224 188819 12021 90427383
Hypersensitivity 287.28 10.46 315 188728 454362 89985042
Musculoskeletal stiffness 284.84 10.46 131 188912 296401 90143003
Cerebral infarction 277.32 10.46 309 188734 26287 90413117
Type 2 diabetes mellitus 276.16 10.46 46 188997 203198 90236206
Haemoglobin decreased 270.05 10.46 847 188196 161109 90278295
Deep vein thrombosis 270.02 10.46 593 188450 91027 90348377
Treatment failure 269.83 10.46 149 188894 303779 90135625
Pericardial haemorrhage 267.61 10.46 112 188931 1764 90437640
Swelling 257.40 10.46 297 188746 418761 90020643
Pain 254.84 10.46 1142 187901 995199 89444205
Stomatitis 253.67 10.46 128 188915 274570 90164834
Bradycardia 251.98 10.46 547 188496 83300 90356104
Sensitisation 249.28 10.46 137 188906 4038 90435366
Atrial flutter 242.67 10.46 192 188851 10566 90428838
Discomfort 241.33 10.46 136 188907 274199 90165205
Pericarditis 237.53 10.46 134 188909 270017 90169387
Blister 235.17 10.46 119 188924 254879 90184525
Joint range of motion decreased 233.21 10.46 12 189031 135631 90303773
Transient ischaemic attack 231.86 10.46 362 188681 42814 90396590
Transfusion 226.41 10.46 228 188815 17260 90422144
Lower respiratory tract infection 225.20 10.46 121 188922 250538 90188866
Injury 225.16 10.46 66 188977 197283 90242121
Haematemesis 221.75 10.46 311 188732 33415 90405989
Haematuria 220.60 10.46 316 188727 34621 90404783
Drug interaction 215.82 10.46 1142 187901 275311 90164093
Sinusitis 211.86 10.46 242 188801 342846 90096558
Upper gastrointestinal haemorrhage 210.99 10.46 250 188793 22726 90416678
Polycystic ovaries 210.82 10.46 137 188906 5517 90433887
C-reactive protein abnormal 210.76 10.46 14 189029 127415 90311989
Ill-defined disorder 210.62 10.46 62 188981 184829 90254575
Haematochezia 207.81 10.46 458 188585 70455 90368949
Product prescribing error 205.70 10.46 283 188760 29862 90409542
Ejection fraction 205.53 10.46 108 188935 2903 90436501
Dyspnoea exertional 204.11 10.46 460 188583 71828 90367576
Bursitis 199.80 10.46 21 189022 131633 90307771
Liver injury 198.34 10.46 55 188988 170512 90268892
Atrial thrombosis 183.70 10.46 91 188952 2154 90437250
Renal disorder 183.54 10.46 303 188740 37556 90401848
Prescribed underdose 183.11 10.46 451 188592 74568 90364836
Lip dry 179.87 10.46 7 189036 100948 90338456
Pulmonary arterial hypertension 178.92 10.46 246 188797 25941 90413463
Syncope 171.17 10.46 637 188406 132026 90307378
Atrial tachycardia 163.99 10.46 120 188923 5870 90433534
Grip strength decreased 162.98 10.46 7 189036 92569 90346835
Alopecia 161.48 10.46 513 188530 494558 89944846
Palmoplantar keratoderma 161.06 10.46 97 188946 3410 90435994
C-reactive protein increased 160.78 10.46 89 188954 181300 90258104
COVID-19 160.54 10.46 738 188305 168105 90271299
Cardiospasm 157.45 10.46 95 188948 3351 90436053
Rectal haemorrhage 156.92 10.46 453 188590 82291 90357113
Labelled drug-drug interaction medication error 156.46 10.46 172 188871 14410 90424994
Mobility decreased 155.64 10.46 176 188867 250558 90188846
Embolic stroke 155.10 10.46 100 188943 3972 90435432
Carotid artery occlusion 153.48 10.46 118 188925 6224 90433180
Arthralgia 150.59 10.46 979 188064 777543 89661861
Sleep disorder due to general medical condition, insomnia type 150.54 10.46 41 189002 128653 90310751
Haemorrhagic stroke 148.81 10.46 117 188926 6379 90433025
Head injury 146.35 10.46 246 188797 30942 90408462
Cardioversion 144.08 10.46 66 188977 1304 90438100
Urticaria 143.66 10.46 271 188772 312463 90126941
Hypercholesterolaemia 143.48 10.46 20 189023 100872 90338532
Intraventricular haemorrhage 141.87 10.46 79 188964 2390 90437014
Arrhythmia 140.88 10.46 288 188755 42044 90397360
Blood test abnormal 140.40 10.46 195 188848 20757 90418647
Live birth 139.19 10.46 6 189037 79101 90360303
Infection 136.52 10.46 350 188693 361744 90077660
Sleep disorder 136.50 10.46 127 188916 197903 90241501
Internal haemorrhage 133.87 10.46 108 188935 6112 90433292
Haematoma muscle 133.85 10.46 69 188974 1781 90437623
Sleep terror 132.66 10.46 94 188949 4370 90435034
Cardiac failure congestive 129.88 10.46 477 188566 98217 90341187
Dementia 129.40 10.46 201 188842 23660 90415744
Pruritus genital 128.61 10.46 93 188950 4465 90434939
Inflammation 126.10 10.46 112 188931 178480 90260924
Wound infection 122.39 10.46 35 189008 106367 90333037
Product use issue 121.98 10.46 322 188721 329597 90109807
Cerebral haematoma 119.86 10.46 87 188956 4202 90435202
Nasopharyngitis 119.67 10.46 441 188602 406663 90032741
Pulmonary fibrosis 118.88 10.46 38 189005 107465 90331939
Abdominal discomfort 117.40 10.46 554 188489 476774 89962630
Ejection fraction abnormal 117.25 10.46 70 188973 2421 90436983
Fluid retention 116.96 10.46 427 188616 87664 90351740
Night sweats 115.81 10.46 62 188981 128704 90310700
Subdural haemorrhage 115.65 10.46 78 188965 3345 90436059
Traumatic intracranial haemorrhage 115.27 10.46 46 188997 637 90438767
Weight increased 114.96 10.46 465 188578 417462 90021942
Hypoaesthesia 112.89 10.46 311 188732 313899 90125505
Pulmonary hypertension 112.73 10.46 264 188779 42259 90397145
Tension headache 112.37 10.46 106 188937 7403 90432001
Pregnancy 111.56 10.46 4 189039 62043 90377361
Immunisation 111.54 10.46 65 188978 2148 90437256
Cardiac ablation 110.31 10.46 59 188984 1645 90437759
Hypervolaemia 109.17 10.46 223 188820 32534 90406870
Cerebral mass effect 107.88 10.46 50 188993 1016 90438388
Vasculitis 107.81 10.46 180 188863 22513 90416891
Post procedural haemorrhage 107.15 10.46 111 188932 8687 90430717
Psoriasis 105.10 10.46 92 188951 147662 90291742
Systemic infection 105.08 10.46 84 188959 4691 90434713
Rhinitis allergic 104.75 10.46 151 188892 16634 90422770
Traumatic haematoma 104.69 10.46 58 188985 1737 90437667
Hyponatraemia 102.92 10.46 550 188493 132988 90306416
Obesity 102.15 10.46 46 188997 105461 90333943
Fibromyalgia 101.65 10.46 171 188872 206098 90233306
Cardiac pacemaker insertion 100.14 10.46 79 188964 4328 90435076
Human rhinovirus test positive 99.70 10.46 45 188998 858 90438546
Injection site reaction 99.27 10.46 34 189009 92046 90347358
Depression 98.22 10.46 311 188732 300290 90139114
Peripheral venous disease 97.64 10.46 27 189016 83894 90355510
Hypothyroidism 96.06 10.46 286 188757 52841 90386563
Palpitations 95.93 10.46 549 188494 136179 90303225
Gastrointestinal disorder 95.24 10.46 250 188793 256437 90182967
Haemarthrosis 93.79 10.46 73 188970 3921 90435483
Carpal tunnel syndrome 93.24 10.46 174 188869 23754 90415650
Dizziness 93.19 10.46 1736 187307 587548 89851856
Respiratory syncytial virus test positive 92.89 10.46 45 188998 1013 90438391
Intentional product use issue 91.10 10.46 768 188275 216124 90223280
Basal ganglia haemorrhage 90.66 10.46 40 189003 721 90438683
Treatment noncompliance 90.26 10.46 275 188768 51452 90387952
Anosmia 90.15 10.46 107 188936 9741 90429663
Pyrexia 90.05 10.46 912 188131 659573 89779831
Blood loss anaemia 89.26 10.46 108 188935 10032 90429372
Diverticulum intestinal haemorrhagic 86.85 10.46 51 188992 1710 90437694
Rash 85.47 10.46 1159 187884 794941 89644463
Red blood cell sedimentation rate increased 84.80 10.46 33 189010 82562 90356842
Osteoarthritis 84.32 10.46 176 188867 195554 90243850
Pulmonary thrombosis 84.18 10.46 103 188940 9679 90429725
Hip arthroplasty 84.14 10.46 27 189016 76181 90363223
Nephrectomy 83.83 10.46 52 188991 1929 90437475
Pain in jaw 83.62 10.46 255 188788 47730 90391674
Cardiac tamponade 83.32 10.46 79 188964 5553 90433851
Autoimmune disorder 83.31 10.46 28 189015 76716 90362688
Road traffic accident 82.79 10.46 62 188981 107564 90331840
Pericardial effusion 82.10 10.46 214 188829 36619 90402785
Haemoptysis 82.00 10.46 201 188842 33119 90406285
Cerebellar haemorrhage 81.86 10.46 48 188995 1605 90437799
Haemorrhage subcutaneous 81.77 10.46 63 188980 3333 90436071
Dehydration 80.84 10.46 687 188356 193760 90245644
Blindness 80.54 10.46 174 188869 26394 90413010
Therapeutic response decreased 79.52 10.46 44 188999 89685 90349719
Vaginal haemorrhage 79.48 10.46 191 188852 31080 90408324
Completed suicide 79.36 10.46 112 188931 144946 90294458
Faeces discoloured 79.32 10.46 152 188891 21168 90418236
Gait inability 79.22 10.46 114 188929 146342 90293062
Nail disorder 78.79 10.46 14 189029 59053 90380351
Facial pain 78.50 10.46 116 188927 13066 90426338
Wrong patient received product 78.30 10.46 62 188981 3415 90435989
Failure to suspend medication 77.57 10.46 21 189022 72 90439332
Oedema peripheral 76.58 10.46 849 188194 257066 90182338
Traumatic haemorrhage 76.39 10.46 33 189010 564 90438840
Heart rate increased 76.36 10.46 449 188594 112453 90326951
Oxygen saturation decreased 76.32 10.46 433 188610 107050 90332354
Retroperitoneal haemorrhage 76.05 10.46 58 188985 3022 90436382
Joint stiffness 75.59 10.46 34 189009 78008 90361396
Lower gastrointestinal haemorrhage 75.50 10.46 93 188950 8799 90430605
Malignant mediastinal neoplasm 75.35 10.46 43 189000 1365 90438039
Wound haemorrhage 73.02 10.46 55 188988 2812 90436592
Full blood count abnormal 72.90 10.46 204 188839 36393 90403011
Ventricular tachycardia 72.82 10.46 160 188883 24548 90414856
Dry mouth 72.34 10.46 174 188869 183885 90255519
Vascular pseudoaneurysm 72.33 10.46 45 188998 1678 90437726
Exostosis 72.18 10.46 12 189031 53122 90386282
Hospice care 72.14 10.46 95 188948 9609 90429795
Cerebral ventricular rupture 71.22 10.46 24 189019 198 90439206
Viral test positive 70.85 10.46 32 189011 611 90438793
Mesenteric haematoma 70.41 10.46 18 189025 46 90439358
Product quality issue 70.15 10.46 39 189004 79286 90360118
Gastric haemorrhage 69.73 10.46 80 188963 7023 90432381
Abdominal wall haematoma 69.60 10.46 57 188986 3295 90436109
Cutaneous vasculitis 68.91 10.46 80 188963 7113 90432291
Adverse event 67.56 10.46 448 188595 116970 90322434
Mouth haemorrhage 67.54 10.46 86 188957 8415 90430989
Sciatica 67.52 10.46 67 188976 101315 90338089
Thrombocytopenia 66.55 10.46 697 188346 208028 90231376
Spontaneous haematoma 66.39 10.46 37 189006 1121 90438283
Pain of skin 65.25 10.46 119 188924 15963 90423441
Retroperitoneal haematoma 65.21 10.46 55 188988 3313 90436091
Nephropathy 64.96 10.46 88 188955 9147 90430257
Haemorrhoidal haemorrhage 64.54 10.46 67 188976 5256 90434148
Therapeutic drug monitoring analysis not performed 64.26 10.46 38 189005 1291 90438113
Lower limb fracture 64.07 10.46 50 188993 84963 90354441
Adrenal haemorrhage 63.86 10.46 28 189015 497 90438907
Laryngitis 63.57 10.46 14 189029 50739 90388665
Thalamus haemorrhage 63.03 10.46 31 189012 722 90438682
Haemothorax 62.95 10.46 47 188996 2371 90437033
Foot deformity 62.63 10.46 23 189020 59628 90379776
Spinal cord haemorrhage 62.31 10.46 23 189020 254 90439150
Lupus-like syndrome 62.14 10.46 13 189030 48833 90390571
Onychomycosis 62.10 10.46 4 189039 37372 90402032
BRASH syndrome 61.54 10.46 42 189001 1837 90437567
Knee arthroplasty 61.34 10.46 50 188993 83132 90356272
Sinus node dysfunction 60.08 10.46 65 188978 5347 90434057
Hypokalaemia 59.71 10.46 473 188570 130643 90308761
Thrombectomy 58.66 10.46 21 189022 211 90439193
Pleural effusion 57.75 10.46 416 188627 111575 90327829
Renal failure 57.70 10.46 469 188574 130538 90308866
Musculoskeletal pain 57.43 10.46 175 188868 171076 90268328
Catheter site haemorrhage 57.24 10.46 53 188990 3615 90435789
Joint dislocation 56.44 10.46 12 189031 44570 90394834
Mixed liver injury 55.70 10.46 74 188969 7549 90431855
Spontaneous haemorrhage 54.94 10.46 28 189015 705 90438699
Vascular device infection 54.38 10.46 93 188950 11859 90427545
Iron deficiency anaemia 54.30 10.46 139 188904 23523 90415881
Sulphaemoglobinaemia 53.94 10.46 25 189018 508 90438896
Conjunctival haemorrhage 53.51 10.46 53 188990 3931 90435473
Muscle haemorrhage 53.48 10.46 49 188994 3297 90436107
Hyperkalaemia 53.08 10.46 272 188771 64692 90374712
Injection site pain 53.05 10.46 185 188858 173514 90265890
Eye haemorrhage 52.76 10.46 84 188959 10096 90429308
Muscle spasticity 52.64 10.46 6 189037 35316 90404088
Pneumonia haemophilus 52.58 10.46 35 189008 1468 90437936
Hip fracture 52.32 10.46 170 188873 32907 90406497
Exercise tolerance decreased 51.67 10.46 71 188972 7480 90431924
Disability 51.51 10.46 11 189032 40734 90398670
Catheter site erythema 51.25 10.46 57 188986 4837 90434567
Lactic acidosis 51.22 10.46 225 188818 50238 90389166
Diarrhoea 51.19 10.46 2421 186622 936769 89502635
Limb injury 50.80 10.46 163 188880 31345 90408059
Coeliac disease 50.69 10.46 15 189028 44595 90394809
Femoral neck fracture 49.72 10.46 82 188961 10151 90429253
Haemoperitoneum 49.38 10.46 48 188995 3480 90435924
Gingival bleeding 49.11 10.46 101 188942 14802 90424602
Circumstance or information capable of leading to medication error 48.86 10.46 56 188987 4911 90434493
Embolism 48.82 10.46 78 188965 9403 90430001
Petechiae 48.75 10.46 104 188939 15637 90423767
Sleep apnoea syndrome 48.28 10.46 161 188882 31586 90407818
Post procedural haematoma 48.12 10.46 32 189011 1340 90438064
Toxicity to various agents 48.10 10.46 377 188666 287469 90151935
Ear infection 47.75 10.46 45 188998 69730 90369674
Cognitive disorder 47.55 10.46 277 188766 69130 90370274
Pulmonary oedema 47.33 10.46 255 188788 61825 90377579
Gastrointestinal tract mucosal pigmentation 47.17 10.46 25 189018 684 90438720
Paraesthesia 47.07 10.46 317 188726 250009 90189395
Duodenal ulcer 47.03 10.46 77 188966 9475 90429929
Infusion site haemorrhage 46.60 10.46 57 188986 5354 90434050
Therapeutic product effect incomplete 46.42 10.46 227 188816 193669 90245735
Cardiac amyloidosis 45.89 10.46 28 189015 1008 90438396
Vena cava filter insertion 45.87 10.46 16 189027 148 90439256
Splenic rupture 45.74 10.46 31 189012 1340 90438064
Medication error 45.71 10.46 318 188725 84334 90355070
Injection site erythema 45.48 10.46 85 188958 98417 90340987
Heavy menstrual bleeding 45.46 10.46 119 188924 20411 90418993
Wrong patient 45.40 10.46 26 189017 831 90438573
Splenic haematoma 45.24 10.46 15 189028 117 90439287
Listless 45.09 10.46 44 188999 3205 90436199
Therapy non-responder 44.91 10.46 141 188902 136563 90302841
Infusion site pain 44.31 10.46 115 188928 19623 90419781
Product monitoring error 44.31 10.46 51 188992 4493 90434911
Device expulsion 44.23 10.46 15 189028 40871 90398533
Acute respiratory failure 44.05 10.46 192 188851 42726 90396678
Antiphospholipid syndrome 43.75 10.46 37 189006 2237 90437167
Tongue biting 43.72 10.46 36 189007 2097 90437307
Burning sensation 43.31 10.46 253 188790 63199 90376205
Gastrointestinal ulcer haemorrhage 43.22 10.46 26 189017 912 90438492
Incorrect route of product administration 43.18 10.46 26 189017 50600 90388804
Hallucination 43.10 10.46 260 188783 65699 90373705
Cardiac failure chronic 43.10 10.46 56 188987 5590 90433814
Foetal exposure during pregnancy 42.76 10.46 18 189025 42957 90396447
Tachycardia 42.71 10.46 510 188533 157163 90282241
Diplopia 42.23 10.46 144 188899 28570 90410834
Heart rate abnormal 42.15 10.46 57 188986 5914 90433490
Cardiac failure acute 41.88 10.46 83 188960 11846 90427558
Multiple sclerosis relapse 41.70 10.46 29 189014 52276 90387128
Neoplasm malignant 41.44 10.46 160 188883 33720 90405684
Right ventricular failure 41.18 10.46 110 188933 19095 90420309
Back injury 41.10 10.46 23 189020 46599 90392805
Tumour haemorrhage 40.14 10.46 34 189009 2060 90437344
Arthritis 39.98 10.46 196 188847 167119 90272285
Insomnia 39.92 10.46 474 188569 333000 90106404
Mast cell activation syndrome 39.32 10.46 30 189013 1564 90437840
Condition aggravated 39.31 10.46 944 188099 594601 89844803
Serotonin syndrome 39.11 10.46 15 189028 37872 90401532
Subcutaneous haematoma 39.06 10.46 32 189011 1851 90437553
Device alarm issue 39.03 10.46 32 189011 1853 90437551
Premature delivery 38.94 10.46 16 189027 38746 90400658
Gout 38.65 10.46 99 188944 16760 90422644
Heart rate irregular 38.63 10.46 125 188918 24143 90415261
Haemangioma of spleen 38.46 10.46 10 189033 28 90439376
Chronic sinusitis 38.24 10.46 3 189040 23799 90415605
Dyspepsia 38.22 10.46 249 188794 197911 90241493
Body temperature increased 38.08 10.46 23 189020 44687 90394717
Abortion spontaneous 38.01 10.46 34 189009 54022 90385382
Liver disorder 37.81 10.46 128 188915 121141 90318263
Cerebrospinal fluid retention 37.69 10.46 12 189031 81 90439323
Finger deformity 37.49 10.46 11 189032 32886 90406518
Large intestinal haemorrhage 37.23 10.46 29 189014 1559 90437845
Antinuclear antibody negative 37.22 10.46 16 189027 270 90439134
Product use in unapproved indication 37.21 10.46 486 188557 335750 90103654
Full blood count decreased 36.96 10.46 141 188902 29548 90409856
Embolic cerebral infarction 36.46 10.46 20 189023 587 90438817
Product label confusion 36.37 10.46 3 189040 22847 90416557
Ear pain 36.31 10.46 40 189003 57662 90381742
Gastritis haemorrhagic 36.10 10.46 30 189013 1770 90437634
Product dispensing error 35.63 10.46 79 188964 12194 90427210
Therapy change 35.57 10.46 63 188980 8259 90431145
Catheter site pruritus 35.41 10.46 33 189010 2269 90437135
Injection site pruritus 35.36 10.46 36 189007 53798 90385606
Catheter site irritation 35.30 10.46 20 189023 626 90438778
Walking aid user 35.12 10.46 15 189028 35491 90403913
Blood urine present 35.09 10.46 97 188946 17181 90422223
Infarction 34.88 10.46 37 189006 2976 90436428
Plasma cell myeloma 34.79 10.46 173 188870 40655 90398749
Lip swelling 34.62 10.46 166 188877 38444 90400960
Catheterisation cardiac 34.52 10.46 47 188996 4909 90434495
Renal haemorrhage 34.48 10.46 24 189019 1084 90438320
Epilepsy 34.48 10.46 75 188968 82131 90357273
Extradural haematoma 34.45 10.46 31 189012 2037 90437367
Immunodeficiency 34.42 10.46 24 189019 43210 90396194
Atrioventricular block 34.22 10.46 64 188979 8751 90430653
Catheter site discharge 34.14 10.46 33 189010 2376 90437028
Hypomagnesaemia 34.10 10.46 156 188887 35432 90403972
Cerebellar infarction 34.03 10.46 32 189011 2226 90437178
Blood immunoglobulin E increased 33.95 10.46 44 188999 4381 90435023
Myocardial infarction 33.33 10.46 353 188690 105619 90333785
Ecchymosis 33.19 10.46 77 188966 12246 90427158
Catheter management 32.90 10.46 36 189007 3000 90436404
Ear haemorrhage 32.85 10.46 27 189016 1569 90437835
Drug tolerance decreased 32.71 10.46 13 189030 32117 90407287
Surgery 32.62 10.46 182 188861 44705 90394699
Angiodermatitis 32.45 10.46 13 189030 182 90439222
Drug abuse 32.22 10.46 78 188965 82269 90357135
Cytomegalovirus infection 32.00 10.46 8 189035 26594 90412810
Product storage error 31.98 10.46 104 188939 20137 90419267
Subclavian vein thrombosis 31.91 10.46 30 189013 2086 90437318
Urinary bladder haemorrhage 31.90 10.46 24 189019 1225 90438179
Skin laceration 31.88 10.46 123 188920 25912 90413492
Fracture 31.85 10.46 110 188933 21966 90417438
Rehabilitation therapy 31.73 10.46 29 189014 1945 90437459
Red blood cell sedimentation rate abnormal 31.71 10.46 6 189037 24198 90415206
Haemorrhagic disorder 31.68 10.46 22 189021 990 90438414
Ocular retrobulbar haemorrhage 31.32 10.46 11 189032 104 90439300
Venous pressure jugular increased 31.24 10.46 18 189025 582 90438822
Vascular device occlusion 31.18 10.46 16 189027 409 90438995
Rheumatoid nodule 31.15 10.46 3 189040 20163 90419241
Cardiac fibrillation 31.13 10.46 18 189025 586 90438818
Thirst decreased 31.11 10.46 15 189028 334 90439070
Cholestasis 31.07 10.46 154 188889 36145 90403259
Anxiety 30.97 10.46 457 188586 309315 90130089
Neovascular age-related macular degeneration 30.89 10.46 16 189027 417 90438987
Intestinal haemorrhage 30.71 10.46 42 189001 4405 90434999
Gastrointestinal angiodysplasia 30.69 10.46 18 189025 602 90438802
Eye pruritus 30.66 10.46 131 188912 28896 90410508
Sepsis 30.50 10.46 536 188507 179278 90260126
Tubulointerstitial nephritis 30.43 10.46 119 188924 25224 90414180
Adverse reaction 30.28 10.46 12 189031 29700 90409704
Normal newborn 30.17 10.46 6 189037 23356 90416048
Subchondral insufficiency fracture 29.91 10.46 9 189034 49 90439355
High frequency ablation 29.89 10.46 13 189030 226 90439178
Drug-induced liver injury 29.77 10.46 93 188950 90225 90349179
Migraine 29.67 10.46 254 188789 190138 90249266
Emotional distress 29.66 10.46 20 189023 36642 90402762
Tooth disorder 29.58 10.46 136 188907 30954 90408450
Anticoagulation drug level abnormal 29.52 10.46 11 189032 125 90439279
Embolism venous 29.36 10.46 37 189006 3583 90435821
White blood cell count increased 29.33 10.46 60 188983 67181 90372223
Anticoagulation drug level increased 29.32 10.46 14 189029 305 90439099
Endocarditis noninfective 29.11 10.46 10 189033 88 90439316
Pulmonary alveolar haemorrhage 29.05 10.46 48 188995 5950 90433454
Coombs positive haemolytic anaemia 29.03 10.46 16 189027 474 90438930
Craniocerebral injury 28.82 10.46 35 189008 3263 90436141
Ovarian cancer 28.63 10.46 51 188992 6716 90432688
Defaecation disorder 28.62 10.46 20 189023 909 90438495
Lung disorder 28.56 10.46 189 188854 149694 90289710
Cerebral artery occlusion 28.50 10.46 21 189022 1038 90438366
Dry skin 28.46 10.46 295 188748 87778 90351626
Craniotomy 28.35 10.46 14 189029 329 90439075
Gastrointestinal tube insertion 28.27 10.46 23 189020 1317 90438087
Multiple epiphyseal dysplasia 28.25 10.46 10 189033 97 90439307
Brain stem haemorrhage 28.23 10.46 19 189024 812 90438592
Calciphylaxis 28.17 10.46 35 189008 3341 90436063
Device pacing issue 28.07 10.46 10 189033 99 90439305
Radiculopathy 27.94 10.46 3 189040 18502 90420902
Central nervous system lupus 27.93 10.46 23 189020 1340 90438064
Sleep disorder due to a general medical condition 27.74 10.46 174 188869 44564 90394840
Myelosuppression 27.72 10.46 43 189000 53548 90385856
Left ventricular failure 27.72 10.46 50 188993 6650 90432754
Sinus bradycardia 27.60 10.46 88 188955 16864 90422540
Off label use 27.58 10.46 2662 186381 1099590 89339814
Skeletal dysplasia 27.37 10.46 10 189033 107 90439297
Gastrointestinal vascular malformation haemorrhagic 27.37 10.46 12 189031 213 90439191
Anti factor X activity increased 27.35 10.46 7 189036 18 90439386
Injection site swelling 27.30 10.46 52 188991 59787 90379617
Cardiac ventricular thrombosis 27.22 10.46 21 189022 1113 90438291
Intracardiac thrombus 27.21 10.46 29 189014 2345 90437059
Reduced facial expression 27.19 10.46 30 189013 2523 90436881
Troponin abnormal 27.17 10.46 9 189034 70 90439334
Duplicate therapy error 27.13 10.46 10 189033 110 90439294
Cerebral artery embolism 27.07 10.46 20 189023 993 90438411
Orthopnoea 27.00 10.46 50 188993 6785 90432619
Cough 26.80 10.46 981 188062 367981 90071423
Hepatotoxicity 26.48 10.46 34 189009 45808 90393596
Frequent bowel movements 26.40 10.46 49 188994 56886 90382518
Prerenal failure 26.33 10.46 27 189016 2088 90437316
Therapy interrupted 26.32 10.46 187 188856 49921 90389483
Microcytic anaemia 26.28 10.46 36 189007 3782 90435622
Muscle twitching 26.17 10.46 110 188933 24092 90415312
Catheter site pain 26.16 10.46 44 188999 5535 90433869
Product dose omission issue 26.15 10.46 795 188248 290892 90148512
Device occlusion 26.11 10.46 59 188984 9223 90430181
Muscle spasms 26.08 10.46 369 188674 251514 90187890
Gastric ulcer 26.06 10.46 120 188923 27328 90412076
Prescription drug used without a prescription 25.97 10.46 33 189010 3222 90436182
Peripheral embolism 25.90 10.46 22 189021 1338 90438066
Hepatic haemangioma rupture 25.87 10.46 5 189038 0 90439404
Mediastinal haematoma 25.82 10.46 9 189034 83 90439321
Feeling abnormal 25.73 10.46 491 188552 166744 90272660
Caesarean section 25.67 10.46 4 189039 18573 90420831
Kyphosis 25.64 10.46 31 189012 2877 90436527
Hepatic cytolysis 25.64 10.46 130 188913 30786 90408618
Osteoporosis 25.48 10.46 109 188934 96422 90342982
Product administration error 25.45 10.46 116 188927 26307 90413097
Polyarthritis 25.25 10.46 4 189039 18346 90421058
Pancreatitis 25.12 10.46 69 188974 69757 90369647
Bicytopenia 25.12 10.46 35 189008 3736 90435668
Blood pressure systolic decreased 25.05 10.46 58 188985 9212 90430192
Orbital compartment syndrome 24.92 10.46 9 189034 93 90439311
Rectal prolapse 24.77 10.46 27 189016 2240 90437164
Paraesthesia oral 24.65 10.46 18 189025 31641 90407763
Urinary tract infection 24.53 10.46 822 188221 304810 90134594
Rectosigmoid cancer 24.40 10.46 11 189032 209 90439195
Irritability 24.40 10.46 23 189020 35639 90403765
Interstitial lung disease 24.25 10.46 255 188788 76150 90363254
Drug withdrawal syndrome 24.15 10.46 15 189028 28708 90410696
Hypoxia 24.11 10.46 244 188799 72155 90367249
Chloropsia 24.06 10.46 8 189035 63 90439341
Creatinine renal clearance abnormal 23.99 10.46 14 189029 464 90438940
Wheezing 23.86 10.46 351 188692 237729 90201675
Butterfly rash 23.83 10.46 26 189017 2159 90437245
Sinobronchitis 23.75 10.46 16 189027 685 90438719
Cardioactive drug level increased 23.65 10.46 27 189016 2357 90437047
Thyrotoxic crisis 23.62 10.46 20 189023 1211 90438193
Duodenal vascular ectasia 23.53 10.46 5 189038 3 90439401
Occult blood positive 23.38 10.46 35 189008 3988 90435416
Atheroembolism 23.29 10.46 6 189037 16 90439388
Neck pain 23.09 10.46 141 188902 113822 90325582
Oedema 23.07 10.46 287 188756 200008 90239396
Eye haematoma 23.00 10.46 9 189034 118 90439286
Echocardiogram abnormal 22.84 10.46 22 189021 1577 90437827
Tinnitus 22.72 10.46 161 188882 42941 90396463
Chronic left ventricular failure 22.67 10.46 15 189028 623 90438781
Nasal congestion 22.66 10.46 270 188773 83144 90356260
Oxygen consumption increased 22.60 10.46 37 189006 4552 90434852
Herpes simplex reactivation 22.58 10.46 18 189025 1001 90438403
Fluid replacement 22.52 10.46 15 189028 630 90438774
Haemorrhage subepidermal 22.42 10.46 5 189038 5 90439399
Dystonia 22.40 10.46 4 189039 16815 90422589
Blood pressure decreased 22.40 10.46 247 188796 74648 90364756
Aneurysm ruptured 22.37 10.46 15 189028 637 90438767
Confusional state 22.29 10.46 624 188419 385581 90053823
Meningorrhagia 22.19 10.46 10 189033 190 90439214
Illness 22.12 10.46 265 188778 81704 90357700
Brain contusion 22.10 10.46 15 189028 650 90438754
Anaemia vitamin B12 deficiency 21.96 10.46 15 189028 657 90438747
Anticoagulation drug level above therapeutic 21.95 10.46 24 189019 1998 90437406
Respiratory disorder 21.88 10.46 66 188977 64750 90374654
Paratonia 21.85 10.46 6 189037 22 90439382
Oral candidiasis 21.85 10.46 25 189018 35430 90403974
Acute myocardial infarction 21.82 10.46 136 188907 34754 90404650
Thrombophlebitis migrans 21.80 10.46 11 189032 271 90439133
Joint effusion 21.72 10.46 7 189036 19703 90419701
Rash papular 21.61 10.46 92 188951 20263 90419141
Drug resistance 21.59 10.46 19 189024 30430 90408974
Blood pressure inadequately controlled 21.48 10.46 43 189000 6181 90433223
Disturbance in attention 21.46 10.46 170 188873 46939 90392465
Bone density decreased 21.29 10.46 5 189038 17340 90422064
Erythema 21.27 10.46 343 188700 228903 90210501
Wrong drug 21.23 10.46 11 189032 287 90439117
Thrombophlebitis 21.22 10.46 37 189006 4791 90434613
Gait disturbance 21.20 10.46 399 188644 260097 90179307
Pulse abnormal 21.14 10.46 29 189014 3050 90436354
Tongue injury 21.12 10.46 14 189029 583 90438821
Urinary retention 21.09 10.46 143 188900 37601 90401803
Asthenia 20.86 10.46 1335 187708 532416 89906988
Encephalopathy 20.83 10.46 167 188876 46277 90393127
Haematoma evacuation 20.72 10.46 9 189034 156 90439248
Dermatitis contact 20.72 10.46 69 188974 13526 90425878
Amyloidosis senile 20.70 10.46 4 189039 0 90439404
Alanine aminotransferase increased 20.68 10.46 153 188890 118185 90321219
Gastrostomy 20.63 10.46 16 189027 855 90438549
Brachydactyly 20.61 10.46 10 189033 226 90439178
Seizure 20.61 10.46 211 188832 152418 90286986
Erysipelas 20.59 10.46 53 188990 8999 90430405
Electrolyte imbalance 20.50 10.46 101 188942 23644 90415760
Pelvic fracture 20.38 10.46 74 188969 15145 90424259
Female genital tract fistula 20.32 10.46 6 189037 17862 90421542
Blood disorder 20.24 10.46 48 188995 7742 90431662
Gastritis erosive 20.20 10.46 44 188999 6711 90432693
Neoplasm 20.12 10.46 52 188991 8851 90430553
COVID-19 pneumonia 19.95 10.46 83 188960 18094 90421310
Colon cancer 19.86 10.46 59 188984 10885 90428519
Erythromelalgia 19.84 10.46 11 189032 330 90439074
Blood creatinine abnormal 19.78 10.46 33 189010 4124 90435280
Listeraemia 19.76 10.46 7 189036 68 90439336
Pustular psoriasis 19.74 10.46 7 189036 18549 90420855
Intra-abdominal haemorrhage 19.69 10.46 26 189017 2636 90436768
Mania 19.61 10.46 3 189040 14121 90425283
Vaginal discharge 19.61 10.46 8 189035 19456 90419948
Dizziness postural 19.56 10.46 52 188991 9001 90430403
Hepatic cirrhosis 19.55 10.46 67 188976 63186 90376218
Coagulation factor V level abnormal 19.50 10.46 5 189038 13 90439391
Foreign body 19.45 10.46 25 189018 2469 90436935
Feeling hot 19.43 10.46 90 188953 77918 90361486
Degenerative aortic valve disease 19.41 10.46 9 189034 183 90439221
Subclavian artery thrombosis 19.41 10.46 9 189034 183 90439221
Wrong strength 19.41 10.46 7 189036 72 90439332
Aortic intramural haematoma 19.41 10.46 8 189035 121 90439283
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.40 10.46 32 189011 3961 90435443
Ovarian cyst 19.36 10.46 6 189037 17312 90422092
Osteopenia 19.35 10.46 12 189031 22990 90416414
Medical observation 19.19 10.46 9 189034 188 90439216
Upper respiratory tract infection 19.18 10.46 173 188870 128145 90311259
Angiodysplasia 19.14 10.46 14 189029 684 90438720
Head discomfort 19.05 10.46 76 188967 16257 90423147
Hypoacusis 18.97 10.46 111 188932 27739 90411665
Subcapsular renal haematoma 18.92 10.46 11 189032 362 90439042
Biliary sepsis 18.88 10.46 16 189027 970 90438434
Mitral valve incompetence 18.88 10.46 95 188948 22429 90416975
Retinal artery embolism 18.75 10.46 7 189036 80 90439324
Hypovolaemic shock 18.75 10.46 44 188999 7050 90432354
Sedation complication 18.71 10.46 6 189037 16938 90422466
Hemiparesis 18.65 10.46 122 188921 31697 90407707
Vomiting 18.64 10.46 1404 187639 786889 89652515
Dialysis 18.62 10.46 59 188984 11270 90428134
Peripheral artery thrombosis 18.58 10.46 23 189020 2187 90437217
Aspartate aminotransferase increased 18.52 10.46 132 188911 102805 90336599
Colitis ulcerative 18.51 10.46 64 188979 60202 90379202
Product complaint 18.44 10.46 3 189040 13497 90425907
Spinal epidural haematoma 18.39 10.46 18 189025 1316 90438088
Influenza like illness 18.35 10.46 96 188947 80515 90358889
Ischaemic cerebral infarction 18.34 10.46 19 189024 1487 90437917
Glomerular filtration rate decreased 18.34 10.46 77 188966 16855 90422549
Hypertensive heart disease 18.33 10.46 25 189018 2615 90436789
Hypercoagulation 18.32 10.46 23 189020 2219 90437185
Glomerular filtration rate abnormal 18.26 10.46 18 189025 1327 90438077
Haemobilia 18.24 10.46 8 189035 142 90439262
Intracranial haematoma 18.20 10.46 11 189032 389 90439015
Hepatocellular injury 18.19 10.46 113 188930 28845 90410559
Device infusion issue 18.17 10.46 25 189018 2637 90436767
Right ventricular enlargement 18.10 10.46 12 189031 500 90438904
Muscle abscess 18.05 10.46 11 189032 395 90439009
Oxygen therapy 18.04 10.46 27 189016 3075 90436329
Basal cell carcinoma 18.03 10.46 26 189017 33363 90406041
Blood pressure abnormal 18.00 10.46 85 188958 19560 90419844
Cutaneous lupus erythematosus 17.94 10.46 27 189016 3091 90436313
Chronic obstructive pulmonary disease 17.92 10.46 234 188809 73595 90365809
Procedural haemorrhage 17.90 10.46 27 189016 3097 90436307
Osteonecrosis of jaw 17.82 10.46 34 189009 39069 90400335
Post procedural pulmonary embolism 17.76 10.46 9 189034 224 90439180
Rash vesicular 17.50 10.46 8 189035 18189 90421215
Infusion site swelling 17.43 10.46 59 188984 11661 90427743
Gastrointestinal polyp haemorrhage 17.42 10.46 11 189032 421 90438983
Prosthetic cardiac valve thrombosis 17.35 10.46 6 189037 54 90439350
Thrombotic stroke 17.32 10.46 12 189031 538 90438866
Cardiac ventricular disorder 17.15 10.46 8 189035 165 90439239
Catheter site rash 17.14 10.46 14 189029 806 90438598
Drug ineffective for unapproved indication 17.13 10.46 76 188967 66568 90372836
Schizophrenia 16.97 10.46 5 189038 14909 90424495
Cerebral artery thrombosis 16.92 10.46 11 189032 443 90438961
Inappropriate antidiuretic hormone secretion 16.87 10.46 83 188960 19422 90419982
Skull fracture 16.86 10.46 17 189026 1288 90438116
Anticoagulation drug level decreased 16.79 10.46 6 189037 60 90439344
Febrile neutropenia 16.73 10.46 231 188812 158118 90281286
Page kidney 16.65 10.46 5 189038 27 90439377
Purpura 16.63 10.46 68 188975 14710 90424694
Blood pressure systolic abnormal 16.61 10.46 10 189033 19468 90419936
Device programming error 16.54 10.46 9 189034 260 90439144
Hypertensive crisis 16.33 10.46 77 188966 17707 90421697
Normocytic anaemia 16.24 10.46 25 189018 2919 90436485
Cerebral ischaemia 16.23 10.46 42 189001 7154 90432250
Prescribed overdose 16.22 10.46 128 188915 97497 90341907
Prothrombin time ratio increased 16.19 10.46 7 189036 120 90439284
Anal haemorrhage 16.18 10.46 23 189020 2501 90436903
Thyroid mass 16.15 10.46 35 189008 5320 90434084
Drug level increased 16.00 10.46 106 188937 27656 90411748
Kidney rupture 15.96 10.46 6 189037 70 90439334
Pallor 15.95 10.46 124 188919 34041 90405363
Taste disorder 15.93 10.46 70 188973 61476 90377928
Infusion site reaction 15.93 10.46 10 189033 19029 90420375
Crying 15.89 10.46 18 189025 25627 90413777
Acquired haemophilia 15.82 10.46 15 189028 1054 90438350
Intracranial haemangioma 15.80 10.46 5 189038 33 90439371
Oesophageal food impaction 15.79 10.46 9 189034 285 90439119
Multiple sclerosis 15.72 10.46 21 189022 27819 90411585
Cerebellar haematoma 15.67 10.46 10 189033 390 90439014
Skin irritation 15.63 10.46 63 188980 13540 90425864
Peptic ulcer 15.62 10.46 35 189008 5440 90433964
Acne 15.59 10.46 22 189021 28485 90410919
Red cell distribution width abnormal 15.57 10.46 8 189035 205 90439199
Haemoglobin abnormal 15.56 10.46 41 189002 7059 90432345
Drug level changed 15.54 10.46 8 189035 206 90439198
Basal ganglia haematoma 15.52 10.46 3 189040 0 90439404
Prohormone brain natriuretic peptide abnormal 15.52 10.46 3 189040 0 90439404
Blood potassium decreased 15.48 10.46 160 188883 47567 90391837
Splenic haemorrhage 15.46 10.46 8 189035 208 90439196
Troponin T increased 15.46 10.46 18 189025 1605 90437799
Product prescribing issue 15.42 10.46 44 188999 7935 90431469
Haemorrhagic diathesis 15.41 10.46 35 189008 5489 90433915
Immune-mediated enterocolitis 15.39 10.46 32 189011 4725 90434679
Infusion site discharge 15.33 10.46 22 189021 2413 90436991
Haemorrhagic hepatic cyst 15.31 10.46 5 189038 37 90439367
Pulmonary haemorrhage 15.31 10.46 44 188999 7969 90431435
Eosinophilia 15.29 10.46 107 188936 28426 90410978
Product administration interrupted 15.28 10.46 59 188984 12433 90426971
Chronic gastrointestinal bleeding 15.25 10.46 7 189036 139 90439265
Hydrocephalus 15.24 10.46 37 189006 6057 90433347
Oesophageal achalasia 15.23 10.46 12 189031 656 90438748
Embolism arterial 15.22 10.46 15 189028 1106 90438298
Periorbital haematoma 15.20 10.46 13 189030 798 90438606
Pulmonary artery occlusion 15.19 10.46 5 189038 38 90439366
Hypertransaminasaemia 15.16 10.46 7 189036 15818 90423586
Hepatitis 15.14 10.46 86 188957 70653 90368751
Morganella infection 15.13 10.46 13 189030 803 90438601
Anal stenosis 15.05 10.46 11 189032 537 90438867
Pituitary apoplexy 14.98 10.46 7 189036 145 90439259
Gastric antral vascular ectasia 14.95 10.46 13 189030 816 90438588
Inability to afford medication 14.94 10.46 27 189016 3595 90435809
Myelocytosis 14.94 10.46 7 189036 146 90439258
Cerebral amyloid angiopathy 14.80 10.46 8 189035 228 90439176
Intensive care 14.77 10.46 16 189027 1318 90438086
Angiogram 14.72 10.46 6 189037 88 90439316
Bone marrow failure 14.70 10.46 28 189015 32193 90407211
Aortic valve disease 14.65 10.46 16 189027 1330 90438074
CNS ventriculitis 14.58 10.46 8 189035 235 90439169
Gingival oedema 14.54 10.46 6 189037 91 90439313
Cardiac operation 14.50 10.46 28 189015 3921 90435483
Brain herniation 14.48 10.46 29 189014 4171 90435233
Traumatic haemothorax 14.34 10.46 8 189035 243 90439161
Injection site urticaria 14.34 10.46 10 189033 18001 90421403
No adverse event 14.28 10.46 210 188833 67772 90371632
Transcatheter aortic valve implantation 14.26 10.46 5 189038 47 90439357
Apathy 14.21 10.46 53 188990 10987 90428417
Spinal fusion surgery 14.19 10.46 4 189039 12279 90427125
Gastric varices haemorrhage 14.16 10.46 7 189036 165 90439239
Coagulation time shortened 14.12 10.46 7 189036 166 90439238
Orthostatic hypotension 13.94 10.46 141 188902 41686 90397718
Anaemia macrocytic 13.92 10.46 30 189013 4542 90434862
Infusion site erythema 13.91 10.46 61 188982 13609 90425795
Jugular vein thrombosis 13.90 10.46 26 189017 3555 90435849
Right atrial dilatation 13.89 10.46 12 189031 747 90438657
Multiple drug therapy 13.89 10.46 39 189004 6970 90432434
Lymphocyte count decreased 13.87 10.46 33 189010 35017 90404387
Infusion site infection 13.85 10.46 22 189021 2638 90436766
Aspiration pleural cavity 13.84 10.46 13 189030 903 90438501
Acute generalised exanthematous pustulosis 13.83 10.46 61 188982 13642 90425762
Impaired work ability 13.77 10.46 12 189031 19314 90420090
Catheter site swelling 13.77 10.46 18 189025 1807 90437597
Alternaria infection 13.75 10.46 9 189034 367 90439037
Tricuspid valve repair 13.74 10.46 4 189039 19 90439385
Diabetes mellitus inadequate control 13.73 10.46 76 188967 18608 90420796
Sinus tachycardia 13.70 10.46 24 189019 28489 90410915
Extra dose administered 13.65 10.46 46 188997 9072 90430332
Food allergy 13.60 10.46 20 189023 25458 90413946
Polyuria 13.60 10.46 49 188994 9991 90429413
Haemorrhagic cyst 13.58 10.46 8 189035 270 90439134
Cyanosis 13.55 10.46 78 188965 19377 90420027
Cardiorenal syndrome 13.49 10.46 14 189029 1098 90438306
Puncture site abscess 13.45 10.46 3 189040 3 90439401
Stroke volume decreased 13.45 10.46 3 189040 3 90439401
Splenic thrombosis 13.41 10.46 4 189039 21 90439383
Sprue-like enteropathy 13.40 10.46 13 189030 940 90438464
White blood cell disorder 13.40 10.46 23 189020 2941 90436463
Aortic stenosis 13.29 10.46 36 189007 6300 90433104
Electrocardiogram QT shortened 13.26 10.46 7 189036 190 90439214
Adrenomegaly 13.22 10.46 6 189037 116 90439288
Amenorrhoea 13.21 10.46 4 189039 11718 90427686
Sensory loss 13.16 10.46 11 189032 18064 90421340
Subcapsular splenic haematoma 13.11 10.46 4 189039 23 90439381
Adrenal haematoma 13.11 10.46 4 189039 23 90439381
Haemophagocytic lymphohistiocytosis 13.10 10.46 8 189035 15451 90423953
Agitation 13.08 10.46 84 188959 67014 90372390
Blood creatinine increased 13.06 10.46 290 188753 101096 90338308
Polyserositis 13.05 10.46 11 189032 662 90438742
Vascular stenosis 13.03 10.46 10 189033 526 90438878
Paroxysmal atrioventricular block 12.99 10.46 3 189040 4 90439400
Microembolism 12.99 10.46 3 189040 4 90439400
Adenocarcinoma of colon 12.98 10.46 22 189021 2784 90436620
Dyspnoea at rest 12.97 10.46 30 189013 4761 90434643
Sedation 12.95 10.46 54 188989 48117 90391287
Tuberculosis 12.90 10.46 5 189038 12544 90426860
Atrioventricular block first degree 12.79 10.46 43 189000 8468 90430936
Skin wound 12.78 10.46 18 189025 1940 90437464
Rash scarlatiniform 12.71 10.46 7 189036 207 90439197
Back pain 12.67 10.46 795 188248 316380 90123024
Ruptured cerebral aneurysm 12.67 10.46 10 189033 548 90438856
Respiratory sinus arrhythmia magnitude 12.61 10.46 5 189038 68 90439336
Prostatic specific antigen abnormal 12.61 10.46 5 189038 68 90439336
Granulomatous dermatitis 12.59 10.46 7 189036 211 90439193
Breast haematoma 12.59 10.46 7 189036 211 90439193
Incorrect dose administered 12.57 10.46 233 188810 78697 90360707
Skin pressure mark 12.56 10.46 4 189039 27 90439377
Treatment delayed 12.56 10.46 9 189034 426 90438978
Abdominal pain 12.56 10.46 686 188357 395035 90044369
Vertigo 12.51 10.46 210 188833 69601 90369803
Dialysis hypotension 12.47 10.46 7 189036 215 90439189
Catheter site warmth 12.36 10.46 7 189036 219 90439185
Bronchospasm 12.33 10.46 15 189028 20694 90418710
Injection site warmth 12.33 10.46 11 189032 17504 90421900
Respiratory failure 12.33 10.46 329 188714 118089 90321315
Right atrial enlargement 12.33 10.46 7 189036 220 90439184
Neurotoxicity 12.31 10.46 16 189027 21451 90417953
Renal infarct 12.30 10.46 16 189027 1599 90437805
Coagulopathy 12.28 10.46 87 188956 23202 90416202
Deformity 12.26 10.46 5 189038 12165 90427239
Malignant atrophic papulosis 12.24 10.46 3 189040 6 90439398
Faeces soft 12.24 10.46 39 189004 7472 90431932
Akathisia 12.23 10.46 4 189039 11155 90428249
Cardiopulmonary failure 12.20 10.46 27 189016 4161 90435243
Intercepted medication error 12.17 10.46 12 189031 885 90438519
Stent placement 12.14 10.46 27 189016 4176 90435228
Walking distance test abnormal 12.14 10.46 10 189033 583 90438821
Rabbit syndrome 12.09 10.46 8 189035 332 90439072
Progressive multifocal leukoencephalopathy 12.06 10.46 9 189034 15646 90423758
Chest wall haematoma 11.99 10.46 7 189036 232 90439172
Gastric ulcer haemorrhage 11.98 10.46 31 189012 5280 90434124
Arterial haemorrhage 11.97 10.46 20 189023 2503 90436901
Hypothermia 11.88 10.46 64 188979 15511 90423893
Blood iron decreased 11.86 10.46 71 188972 17888 90421516
Troponin increased 11.83 10.46 57 188986 13224 90426180
Humerus fracture 11.79 10.46 46 188997 9739 90429665
Central venous catheterisation 11.79 10.46 21 189022 2765 90436639
Mechanical ileus 11.78 10.46 11 189032 758 90438646
Pneumonia 11.75 10.46 1511 187532 636548 89802856
Cholecystitis chronic 11.73 10.46 3 189040 9823 90429581
Atrioventricular block complete 11.72 10.46 46 188997 9765 90429639
Haemorrhagic transformation stroke 11.70 10.46 14 189029 1285 90438119
Pulmonary haematoma 11.67 10.46 6 189037 154 90439250
Congenital absence of bile ducts 11.66 10.46 4 189039 35 90439369
Oral mucosa haematoma 11.64 10.46 3 189040 8 90439396
Lacunar stroke 11.62 10.46 7 189036 246 90439158
Anaphylactic shock 11.55 10.46 31 189012 31586 90407818
Herbal interaction 11.49 10.46 6 189037 159 90439245
Blood calcium decreased 11.48 10.46 29 189014 30153 90409251
Abdominal wall cyst 11.47 10.46 4 189039 37 90439367
Bleeding time prolonged 11.43 10.46 10 189033 633 90438771
Haemoglobin increased 11.43 10.46 38 189005 7443 90431961
Therapeutic embolisation 11.42 10.46 7 189036 254 90439150
Arterial injury 11.42 10.46 8 189035 365 90439039
Factor Xa activity increased 11.38 10.46 3 189040 9 90439395
Nail bed tenderness 11.33 10.46 8 189035 370 90439034
Electrocardiogram abnormal 11.28 10.46 47 188996 10251 90429153
Amaurosis fugax 11.27 10.46 10 189033 645 90438759
Premature baby 11.26 10.46 22 189021 25055 90414349
Faecal vomiting 11.25 10.46 11 189032 803 90438601
Gestational diabetes 11.24 10.46 4 189039 10578 90428826
Procedural pain 11.24 10.46 34 189009 33326 90406078
Tendonitis 11.19 10.46 17 189026 21355 90418049
Loss of consciousness 11.19 10.46 377 188666 139861 90299543
Respiratory arrest 11.19 10.46 34 189009 33277 90406127
Listeria encephalitis 11.18 10.46 7 189036 264 90439140
Marasmus 11.15 10.46 11 189032 812 90438592
Spondylitis 11.12 10.46 8 189035 14170 90425234
Gastrointestinal toxicity 11.10 10.46 3 189040 9464 90429940
Clostridium difficile infection 11.05 10.46 120 188923 36125 90403279
Umbilical hernia 11.04 10.46 24 189019 3656 90435748
Left ventricular dysfunction 11.01 10.46 60 188983 14609 90424795
Gastrointestinal oedema 10.98 10.46 15 189028 1571 90437833
Heparin-induced thrombocytopenia 10.96 10.46 30 189013 5282 90434122
Emergency care 10.96 10.46 15 189028 1574 90437830
Mite allergy 10.96 10.46 11 189032 829 90438575
Brain compression 10.90 10.46 9 189034 526 90438878
Carotid artery stenosis 10.88 10.46 30 189013 5304 90434100
N-terminal prohormone brain natriuretic peptide increased 10.87 10.46 21 189022 2941 90436463
Circulatory collapse 10.87 10.46 89 188954 24815 90414589
Blood blister 10.86 10.46 18 189025 2237 90437167
Inferior vena cava dilatation 10.86 10.46 5 189038 100 90439304
Product commingling 10.85 10.46 6 189037 179 90439225
Ankylosing spondylitis 10.84 10.46 7 189036 13126 90426278
Intentional product misuse 10.83 10.46 254 188789 89350 90350054
Skin haemorrhage 10.77 10.46 79 188964 21301 90418103
Kussmaul respiration 10.77 10.46 7 189036 282 90439122
Liver function test increased 10.76 10.46 119 188924 84736 90354668
Colitis microscopic 10.75 10.46 49 188994 11110 90428294
Pericardial drainage 10.75 10.46 7 189036 283 90439121
Phlebitis 10.70 10.46 37 189006 7393 90432011
Antinuclear antibody positive 10.70 10.46 3 189040 9238 90430166
Manufacturing product shipping issue 10.64 10.46 5 189038 105 90439299
Deprescribing error 10.61 10.46 4 189039 47 90439357
Sudden death 10.58 10.46 48 188995 10861 90428543
Urinary tract infection bacterial 10.57 10.46 33 189010 6252 90433152
Macular degeneration 10.56 10.46 42 189001 37928 90401476
Shock 10.56 10.46 99 188944 28679 90410725
Posterior reversible encephalopathy syndrome 10.55 10.46 19 189024 22320 90417084
Peripheral coldness 10.54 10.46 57 188986 13835 90425569
Splenomegaly 10.52 10.46 7 189036 12917 90426487
Cerebellar stroke 10.50 10.46 8 189035 416 90438988
Angioedema 10.50 10.46 192 188851 64684 90374720
Accidental exposure to product 10.48 10.46 49 188994 42317 90397087
Jejunectomy 10.47 10.46 4 189039 49 90439355

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 1209.81 11.16 1720 170650 96006 42352959
Haemorrhage 1155.10 11.16 1322 171048 59241 42389724
Atrial fibrillation 903.25 11.16 1840 170530 137753 42311212
Cerebral haemorrhage 843.13 11.16 909 171461 38057 42410908
Death 804.62 11.16 3892 168478 467293 41981672
Haemorrhage intracranial 641.19 11.16 542 171828 16650 42432315
Prescribed underdose 623.57 11.16 433 171937 9849 42439116
Cerebrovascular accident 562.84 11.16 1225 171145 95935 42353030
Gastric haemorrhage 537.20 11.16 399 171971 10116 42438849
Subdural haematoma 488.43 11.16 533 171837 22605 42426360
Haematuria 446.41 11.16 822 171548 56977 42391988
Fall 440.07 11.16 1995 170375 232525 42216440
Drug ineffective 432.08 11.16 1224 171146 628973 41819992
Thrombosis 431.43 11.16 894 171476 67617 42381348
Melaena 390.07 11.16 620 171750 38126 42410839
Haematoma 332.39 11.16 484 171886 27539 42421426
Epistaxis 278.30 11.16 742 171628 66084 42382881
Subarachnoid haemorrhage 265.50 11.16 310 172060 14162 42434803
Drug abuse 265.14 11.16 51 172319 104720 42344245
Adverse event 256.99 11.16 392 171978 23248 42425717
Ischaemic stroke 249.25 11.16 374 171996 21859 42427106
Toxicity to various agents 246.78 11.16 340 172030 228796 42220169
Cardiac failure 243.22 11.16 965 171405 105891 42343074
Atrial thrombosis 241.03 11.16 140 172230 2304 42446661
Lower gastrointestinal haemorrhage 231.55 11.16 251 172119 10557 42438408
Anaemia 228.24 11.16 1922 170448 278356 42170609
Pericardial haemorrhage 227.44 11.16 155 172215 3414 42445551
Pulmonary embolism 221.03 11.16 1014 171356 118598 42330367
Transfusion 200.88 11.16 230 172140 10284 42438681
Intentional product use issue 197.86 11.16 690 171680 71143 42377822
Haemorrhagic stroke 194.84 11.16 192 172178 7210 42441755
Cardiac amyloidosis 179.77 11.16 108 172262 1897 42447068
Haemoptysis 174.61 11.16 495 171875 45672 42403293
Cerebral infarction 168.88 11.16 383 171987 30786 42418179
Upper gastrointestinal haemorrhage 168.29 11.16 376 171994 29923 42419042
Shock haemorrhagic 167.65 11.16 263 172107 15979 42432986
Dyspnoea 165.13 11.16 2607 169763 440014 42008951
Post procedural haemorrhage 163.39 11.16 195 172175 9117 42439848
Pyrexia 162.94 11.16 932 171438 393110 42055855
Haemoglobin decreased 162.36 11.16 1003 171367 131468 42317497
Labelled drug-drug interaction medication error 161.79 11.16 253 172117 15329 42433636
Pulmonary alveolar haemorrhage 151.66 11.16 239 172131 14577 42434388
Haematochezia 151.20 11.16 550 171820 57886 42391079
Hospitalisation 150.68 11.16 648 171722 73682 42375283
Completed suicide 147.55 11.16 105 172265 96360 42352605
Spirometry abnormal 140.14 11.16 136 172234 5010 42443955
Febrile neutropenia 138.91 11.16 344 172026 185359 42263606
Foetal exposure during pregnancy 135.72 11.16 16 172354 47295 42401670
Conjunctivitis allergic 134.95 11.16 142 172228 5769 42443196
Mycotic allergy 128.97 11.16 127 172243 4764 42444201
Mite allergy 127.47 11.16 128 172242 4918 42444047
Cerebral haematoma 126.71 11.16 134 172236 5476 42443489
Transient ischaemic attack 123.91 11.16 358 172012 33381 42415584
Head injury 122.90 11.16 263 172107 20319 42428646
Embolic stroke 122.12 11.16 125 172245 4915 42444050
Dust allergy 121.57 11.16 128 172242 5204 42443761
Drug hypersensitivity 116.62 11.16 138 172232 99251 42349714
Cardiospasm 110.21 11.16 78 172292 1829 42447136
Rectal haemorrhage 107.14 11.16 441 171929 49165 42399800
Cardioversion 105.82 11.16 60 172310 941 42448024
Internal haemorrhage 104.25 11.16 119 172251 5302 42443663
Cardiac disorder 103.32 11.16 432 171938 48500 42400465
Therapy interrupted 101.72 11.16 256 172114 21994 42426971
N-terminal prohormone brain natriuretic peptide increased 101.13 11.16 95 172275 3358 42445607
Mucosal inflammation 100.38 11.16 37 172333 49337 42399628
Alanine aminotransferase increased 99.24 11.16 127 172243 88279 42360686
Seizure 99.23 11.16 212 172158 120349 42328616
Palmoplantar keratoderma 98.57 11.16 78 172292 2176 42446789
Deep vein thrombosis 96.26 11.16 586 171784 76371 42372594
Abdominal wall haematoma 94.42 11.16 77 172293 2245 42446720
Pruritus genital 93.86 11.16 81 172289 2558 42446407
Drug resistance 92.47 11.16 14 172356 34234 42414731
Atrial tachycardia 91.93 11.16 98 172272 4042 42444923
Stress 91.81 11.16 32 172338 44180 42404785
Drug dependence 90.95 11.16 7 172363 29087 42419878
Suicidal ideation 88.41 11.16 42 172328 48119 42400846
Aortic valve stenosis 88 11.16 83 172287 2949 42446016
Traumatic intracranial haemorrhage 87.60 11.16 48 172322 702 42448263
Aggression 86.62 11.16 35 172335 44128 42404837
Diverticulum intestinal haemorrhagic 84.49 11.16 81 172289 2938 42446027
Nausea 84.10 11.16 1116 171254 395683 42053282
Peripheral swelling 84.01 11.16 639 171731 89631 42359334
Vasculitis 83.42 11.16 211 172159 18183 42430782
Dizziness 83.22 11.16 1443 170927 247811 42201154
Right atrial hypertrophy 82.87 11.16 46 172324 691 42448274
Intraventricular haemorrhage 82.83 11.16 90 172280 3794 42445171
Normochromic normocytic anaemia 82.00 11.16 138 172232 8893 42440072
Aspartate aminotransferase increased 81.38 11.16 116 172254 77047 42371918
Sleep terror 80.94 11.16 78 172292 2848 42446117
Pulmonary vasculitis 79.80 11.16 112 172258 6154 42442811
Vomiting 78.49 11.16 771 171599 288952 42160013
Dyspnoea exertional 77.34 11.16 404 171966 49744 42399221
Disease progression 77.10 11.16 309 172061 143347 42305618
Thalamus haemorrhage 77.06 11.16 51 172319 1068 42447897
Blood loss anaemia 77.00 11.16 140 172230 9596 42439369
Faeces discoloured 75.94 11.16 194 172176 16820 42432145
Carotid artery occlusion 75.51 11.16 89 172281 4105 42444860
Fluid retention 75.41 11.16 290 172080 31329 42417636
Haematoma muscle 74.46 11.16 65 172305 2085 42446880
Tension headache 74.37 11.16 80 172290 3334 42445631
Anticoagulant-related nephropathy 73.90 11.16 27 172343 136 42448829
Procedural haemorrhage 73.48 11.16 73 172297 2768 42446197
Product use in unapproved indication 71.87 11.16 444 171926 184012 42264953
Immunisation 71.65 11.16 51 172319 1207 42447758
Haemorrhagic cholecystitis 71.65 11.16 26 172344 128 42448837
Sleep disorder due to a general medical condition 70.76 11.16 192 172178 17261 42431704
Sedation 70.65 11.16 18 172352 30457 42418508
Myelosuppression 70.20 11.16 38 172332 40423 42408542
Depression 69.38 11.16 225 172145 111138 42337827
Blood urine present 68.97 11.16 149 172221 11584 42437381
Haemothorax 68.79 11.16 95 172275 5141 42443824
Cytomegalovirus infection 67.73 11.16 23 172347 32283 42416682
Leukopenia 67.00 11.16 125 172245 74621 42374344
Overdose 66.74 11.16 211 172159 105053 42343912
Traumatic haemorrhage 66.42 11.16 49 172321 1228 42447737
Cardiac ablation 65.98 11.16 49 172321 1241 42447724
Agitation 64.59 11.16 100 172270 64214 42384751
Haematemesis 64.03 11.16 267 172103 29932 42419033
Somnolence 64.01 11.16 323 172047 140782 42308183
Product prescribing error 63.51 11.16 241 172129 25871 42423094
Neuritis 63.18 11.16 100 172270 6120 42442845
Haemoperitoneum 62.74 11.16 58 172312 2008 42446957
Subdural haemorrhage 62.55 11.16 74 172296 3427 42445538
Urinary bladder haemorrhage 62.28 11.16 55 172315 1792 42447173
Hepatic function abnormal 62.19 11.16 70 172300 51497 42397468
Injection site pain 61.82 11.16 86 172284 57712 42391253
Premature baby 61.29 11.16 10 172360 23143 42425822
Cardiac failure chronic 61.17 11.16 126 172244 9475 42439490
Multiple organ dysfunction syndrome 60.47 11.16 196 172174 96839 42352126
Contraindicated product administered 60.44 11.16 232 172138 25040 42423925
Atrial flutter 60.41 11.16 180 172190 17071 42431894
Right ventricular hypertrophy 60.04 11.16 50 172320 1502 42447463
Contusion 59.15 11.16 330 172040 41655 42407310
Neutropenia 57.66 11.16 522 171848 198909 42250056
Facial pain 57.03 11.16 78 172292 4182 42444783
Anosmia 56.47 11.16 86 172284 5090 42443875
Cerebral ventricular rupture 56.29 11.16 24 172346 193 42448772
Blood cholesterol increased 56.13 11.16 19 172351 26722 42422243
Cerebellar haemorrhage 56.09 11.16 50 172320 1650 42447315
Drug withdrawal syndrome 55.52 11.16 10 172360 21539 42427426
Adrenal haemorrhage 55.38 11.16 27 172343 305 42448660
Infusion related reaction 55.10 11.16 101 172269 60705 42388260
Respiratory depression 55.06 11.16 6 172364 18862 42430103
Diabetes mellitus 54.27 11.16 100 172270 59987 42388978
Renal impairment 53.93 11.16 682 171688 109546 42339419
Coagulation factor deficiency 53.76 11.16 25 172345 252 42448713
Stomatitis 52.72 11.16 76 172294 50253 42398712
Bronchial secretion retention 52.49 11.16 47 172323 1560 42447405
Arrhythmia 52.29 11.16 310 172060 40007 42408958
Arteriovenous malformation 52.27 11.16 36 172334 807 42448158
Cardiac failure congestive 51.85 11.16 552 171818 85050 42363915
Cerebral mass effect 51.66 11.16 43 172327 1291 42447674
Large intestine polyp 51.45 11.16 115 172255 9150 42439815
Bronchial wall thickening 50.93 11.16 43 172327 1317 42447648
Cutaneous vasculitis 50.93 11.16 96 172274 6764 42442201
Total lung capacity abnormal 50.14 11.16 75 172295 4368 42444597
Spinal cord haemorrhage 49.66 11.16 25 172345 304 42448661
Neutrophil count decreased 49.29 11.16 115 172255 63300 42385665
Haemorrhage subcutaneous 49.05 11.16 57 172313 2589 42446376
Rhabdomyolysis 49.01 11.16 157 172213 77862 42371103
Blood lactate dehydrogenase increased 49.01 11.16 22 172348 26059 42422906
Incorrect route of product administration 48.09 11.16 19 172351 24286 42424679
Nodule 47.95 11.16 135 172235 12399 42436566
Gastrointestinal arteriovenous malformation 47.54 11.16 25 172345 335 42448630
Therapeutic product effect decreased 47.36 11.16 53 172317 39097 42409868
Erythema 46.54 11.16 254 172116 108539 42340426
Post procedural haematoma 46.24 11.16 44 172326 1581 42447384
Polypectomy 45.84 11.16 30 172340 616 42448349
Full blood count abnormal 45.58 11.16 240 172130 29636 42419329
Neutrophil count increased 45.33 11.16 12 172358 19792 42429173
Pulmonary arterial hypertension 45.30 11.16 116 172254 10071 42438894
Drug ineffective for unapproved indication 45.18 11.16 73 172297 46090 42402875
Pulmonary function test abnormal 44.95 11.16 55 172315 2639 42446326
Therapeutic response decreased 44.89 11.16 50 172320 36962 42412003
Gastrointestinal angiodysplasia 44.52 11.16 30 172340 648 42448317
Glomerular filtration rate abnormal 44.51 11.16 38 172332 1182 42447783
Sepsis 44.15 11.16 555 171815 198779 42250186
Pain 43.93 11.16 711 171659 244137 42204828
Musculoskeletal stiffness 43.90 11.16 106 172264 57659 42391306
Upper respiratory tract infection 43.86 11.16 64 172306 42109 42406856
Spontaneous haematoma 43.80 11.16 31 172339 727 42448238
Hypophosphataemia 43.75 11.16 15 172355 20930 42428035
Iron deficiency anaemia 43.72 11.16 134 172236 12905 42436060
Extrapyramidal disorder 43.64 11.16 7 172363 16405 42432560
Haemorrhoidal haemorrhage 43.46 11.16 68 172302 4120 42444845
Eosinophilic granulomatosis with polyangiitis 43.32 11.16 103 172267 8535 42440430
High frequency ablation 43.11 11.16 19 172351 167 42448798
Duodenal ulcer 42.87 11.16 128 172242 12151 42436814
Abnormal behaviour 42.82 11.16 27 172343 26424 42422541
Coagulation factor V level abnormal 42.62 11.16 18 172352 141 42448824
Haemorrhagic disorder 42.57 11.16 31 172339 761 42448204
Retroperitoneal haematoma 42.57 11.16 57 172313 2994 42445971
Emotional distress 42.49 11.16 7 172363 16086 42432879
Haemorrhage urinary tract 42.17 11.16 47 172323 2039 42446926
Poisoning 42.08 11.16 5 172365 14694 42434271
Arteriosclerosis coronary artery 41.86 11.16 168 172202 18509 42430456
Bacterial infection 41.74 11.16 31 172339 27848 42421117
Haemorrhagic hepatic cyst 41.60 11.16 11 172359 12 42448953
Intentional self-injury 41.53 11.16 6 172364 15196 42433769
Hyperphosphataemia 41.01 11.16 3 172367 13001 42435964
IVth nerve paralysis 40.85 11.16 27 172343 564 42448401
Arteriosclerosis 40.46 11.16 162 172208 17827 42431138
Duodenal ulcer haemorrhage 40.32 11.16 79 172291 5729 42443236
Urogenital haemorrhage 40.07 11.16 29 172341 705 42448260
Pancytopenia 40.02 11.16 295 172075 117448 42331517
Gastrointestinal endoscopic therapy 39.87 11.16 10 172360 7 42448958
Nightmare 39.85 11.16 26 172344 24986 42423979
Prescribed overdose 39.81 11.16 129 172241 12798 42436167
Failure to suspend medication 39.57 11.16 23 172347 379 42448586
Cardiac tamponade 39.53 11.16 84 172286 6456 42442509
Psychotic disorder 39.37 11.16 36 172334 29172 42419793
Diastolic dysfunction 39.14 11.16 87 172283 6896 42442069
White blood cell count increased 38.99 11.16 77 172293 45010 42403955
Neuroleptic malignant syndrome 38.98 11.16 19 172351 21453 42427512
Blood creatine phosphokinase increased 38.91 11.16 86 172284 48252 42400713
Suicide attempt 38.79 11.16 80 172290 46020 42402945
Neurological symptom 38.60 11.16 108 172262 9883 42439082
Graft versus host disease 38.00 11.16 4 172366 12921 42436044
Mixed liver injury 37.51 11.16 66 172304 4408 42444557
Osteonecrosis of jaw 37.51 11.16 15 172355 19034 42429931
Hypotension 37.33 11.16 1332 171038 256299 42192666
Splenic rupture 36.59 11.16 39 172331 1608 42447357
Abdominal pain 36.54 11.16 546 171824 189925 42259040
Spinal subarachnoid haemorrhage 36.52 11.16 12 172358 41 42448924
Lymphadenopathy 36.32 11.16 49 172321 33316 42415649
Muscle haemorrhage 36.08 11.16 62 172308 4063 42444902
Factor V Leiden mutation 35.68 11.16 18 172352 220 42448745
Brain stem haemorrhage 35.68 11.16 31 172339 988 42447977
IgA nephropathy 35.68 11.16 46 172324 2328 42446637
Bone marrow failure 35.62 11.16 49 172321 33044 42415921
Cardiac pacemaker insertion 35.48 11.16 54 172316 3194 42445771
COVID-19 35.31 11.16 662 171708 115286 42333679
Nephropathy toxic 35.27 11.16 12 172358 16826 42432139
BRASH syndrome 34.98 11.16 40 172330 1785 42447180
Hypovolaemic shock 34.84 11.16 95 172275 8564 42440401
Drug intolerance 34.81 11.16 187 172183 80237 42368728
Haematoma evacuation 34.77 11.16 18 172352 233 42448732
Catheter site haemorrhage 34.63 11.16 47 172323 2501 42446464
Urticaria 34.39 11.16 168 172202 73868 42375097
Tremor 34.32 11.16 240 172130 96689 42352276
General physical health deterioration 34.24 11.16 827 171543 150419 42298546
Hallucination, auditory 34.03 11.16 9 172361 14855 42434110
Hemiparesis 34.03 11.16 150 172220 17226 42431739
Urethral haemorrhage 34.00 11.16 23 172347 500 42448465
Ventricular tachycardia 33.55 11.16 223 172147 29937 42419028
Antineutrophil cytoplasmic antibody positive 33.55 11.16 62 172308 4303 42444662
Appendicitis 33.42 11.16 21 172349 20592 42428373
Drug level increased 33.33 11.16 34 172336 26166 42422799
Injection site reaction 33.29 11.16 11 172359 15710 42433255
Posterior reversible encephalopathy syndrome 32.92 11.16 6 172364 12815 42436150
Systemic infection 32.79 11.16 68 172302 5137 42443828
Respiratory symptom 32.56 11.16 109 172261 10997 42437968
Ulcer haemorrhage 32.49 11.16 51 172319 3099 42445866
Serotonin syndrome 32.35 11.16 34 172336 25811 42423154
Pain of skin 31.86 11.16 88 172282 7992 42440973
Therapeutic drug monitoring analysis not performed 31.78 11.16 23 172347 559 42448406
Respiratory arrest 31.70 11.16 41 172329 28383 42420582
Mania 31.70 11.16 3 172367 10544 42438421
Obstruction 31.67 11.16 50 172320 3053 42445912
Capillaritis 31.66 11.16 42 172328 2186 42446779
Therapy partial responder 31.64 11.16 21 172349 20000 42428965
Malignant neoplasm progression 31.60 11.16 283 172087 108117 42340848
Generalised tonic-clonic seizure 31.59 11.16 36 172334 26343 42422622
Gastric ulcer 31.58 11.16 152 172218 18110 42430855
Ventricular fibrillation 31.04 11.16 46 172324 30077 42418888
Rheumatoid arthritis 30.59 11.16 80 172290 42360 42406605
Gastrointestinal tube insertion 30.49 11.16 34 172336 1476 42447489
Splenic haemorrhage 30.46 11.16 22 172348 533 42448432
Amyloidosis 30.45 11.16 43 172327 2376 42446589
Chronic left ventricular failure 30.42 11.16 25 172345 737 42448228
Aspergillus infection 30.33 11.16 13 172357 15824 42433141
Impaired work ability 30.32 11.16 6 172364 12085 42436880
Pathogen resistance 30.18 11.16 5 172365 11445 42437520
Multiple sclerosis relapse 30.17 11.16 10 172360 14254 42434711
Lymphocyte count decreased 30.11 11.16 41 172329 27768 42421197
Surgery 30.02 11.16 146 172224 17470 42431495
Obstructive airways disorder 29.96 11.16 187 172183 24572 42424393
Pericardial effusion 29.92 11.16 212 172158 29063 42419902
Acute kidney injury 29.90 11.16 1792 170578 365545 42083420
Blood phosphorus increased 29.81 11.16 7 172363 12518 42436447
Gastric ulcer haemorrhage 29.59 11.16 72 172298 6055 42442910
Haemorrhagic diathesis 29.31 11.16 49 172321 3140 42445825
Cytomegalovirus infection reactivation 29.20 11.16 5 172365 11173 42437792
Mitral valve incompetence 29.06 11.16 138 172232 16351 42432614
Atheroembolism 29.05 11.16 18 172352 335 42448630
Irritability 28.94 11.16 43 172327 28085 42420880
Psoriatic arthropathy 28.90 11.16 35 172335 24932 42424033
Traumatic haemothorax 28.83 11.16 19 172351 395 42448570
Haemorrhagic ascites 28.80 11.16 14 172356 157 42448808
Candida infection 28.69 11.16 27 172343 21583 42427382
Basal ganglia haemorrhage 28.66 11.16 28 172342 1040 42447925
Haemorrhoids 28.63 11.16 141 172229 16956 42432009
Neuralgia 28.60 11.16 37 172333 25610 42423355
Chills 28.56 11.16 243 172127 93823 42355142
Renal haemorrhage 28.56 11.16 34 172336 1585 42447380
Withdrawal syndrome 28.50 11.16 12 172358 14763 42434202
Cardiac ventricular thrombosis 28.48 11.16 36 172334 1786 42447179
Psychomotor hyperactivity 28.41 11.16 5 172365 10953 42438012
Retroperitoneal haemorrhage 28.36 11.16 48 172322 3107 42445858
Progressive multifocal leukoencephalopathy 28.35 11.16 6 172364 11530 42437435
Productive cough 28.22 11.16 326 172044 51241 42397724
Vascular pseudoaneurysm 28.10 11.16 44 172326 2668 42446297
Pericarditis 27.82 11.16 118 172252 13326 42435639
Hepatitis C 27.68 11.16 4 172366 10129 42438836
Hypertriglyceridaemia 27.65 11.16 4 172366 10122 42438843
Lung disorder 27.60 11.16 306 172064 47617 42401348
Miosis 27.45 11.16 10 172360 13436 42435529
Intracranial haematoma 27.35 11.16 21 172349 560 42448405
Anti factor Xa activity decreased 27.29 11.16 7 172363 6 42448959
Renal haematoma 27.25 11.16 22 172348 632 42448333
Transaminases increased 26.88 11.16 58 172312 32827 42416138
Fear 26.35 11.16 6 172364 10959 42438006
Cerebral thrombosis 26.25 11.16 26 172344 982 42447983
Liver disorder 26.15 11.16 78 172292 39566 42409399
Wound haemorrhage 26.06 11.16 39 172331 2272 42446693
Anger 26.04 11.16 10 172360 13008 42435957
Dry mouth 25.92 11.16 79 172291 39800 42409165
Neoplasm malignant 25.81 11.16 169 172201 22574 42426391
Eye haemorrhage 25.76 11.16 59 172311 4771 42444194
Bradycardia 25.64 11.16 487 171883 84997 42363968
Substance abuse 25.56 11.16 3 172367 8902 42440063
Ascites 25.52 11.16 130 172240 56548 42392417
Myoclonus 25.51 11.16 19 172351 17046 42431919
Pulmonary thrombosis 25.43 11.16 83 172287 8265 42440700
Cardiac flutter 25.41 11.16 37 172333 2103 42446862
Polyp 25.31 11.16 57 172313 4557 42444408
Laryngeal haemorrhage 25.19 11.16 9 172361 42 42448923
Purpura 25.15 11.16 105 172265 11774 42437191
BK virus infection 25.11 11.16 3 172367 8781 42440184
Percutaneous coronary intervention 25.09 11.16 15 172355 261 42448704
Synovitis 25.05 11.16 16 172354 15551 42433414
Respiratory failure 25.00 11.16 366 172004 127766 42321199
Ejection fraction decreased 24.99 11.16 164 172206 21923 42427042
Platelet count decreased 24.94 11.16 402 171968 138179 42310786
Hepatic steatosis 24.90 11.16 30 172340 21418 42427547
Tumour lysis syndrome 24.86 11.16 32 172338 22199 42426766
Therapy non-responder 24.82 11.16 121 172249 53238 42395727
Systemic lupus erythematosus 24.74 11.16 4 172366 9320 42439645
Wheezing 24.69 11.16 334 172036 54447 42394518
Blood triglycerides increased 24.68 11.16 17 172353 15879 42433086
Haemobilia 24.68 11.16 18 172352 443 42448522
Neoplasm progression 24.67 11.16 50 172320 28950 42420015
Fungal infection 24.62 11.16 26 172344 19696 42429269
Diverticulum intestinal 24.60 11.16 60 172310 5053 42443912
Aortic valve disease 24.59 11.16 29 172341 1338 42447627
Osteonecrosis 24.59 11.16 17 172353 15848 42433117
Psoriasis 24.52 11.16 107 172263 48497 42400468
Haematotoxicity 24.49 11.16 7 172363 10978 42437987
Therapy cessation 24.46 11.16 154 172216 20296 42428669
Prosthetic cardiac valve thrombosis 24.42 11.16 8 172362 27 42448938
Intra-abdominal haemorrhage 24.30 11.16 43 172327 2885 42446080
Renal tubular necrosis 24.29 11.16 23 172347 18331 42430634
Treatment noncompliance 24.24 11.16 246 172124 37426 42411539
Product quality issue 24.15 11.16 22 172348 17860 42431105
Post transplant lymphoproliferative disorder 24.00 11.16 4 172366 9116 42439849
Hemiparaesthesia 23.97 11.16 13 172357 186 42448779
Acute myeloid leukaemia 23.91 11.16 33 172337 22223 42426742
Diverticulum 23.90 11.16 76 172294 7465 42441500
Nasopharyngitis 23.73 11.16 221 172149 83775 42365190
Interstitial lung disease 23.53 11.16 447 171923 78015 42370950
Eye pruritus 23.48 11.16 100 172270 11312 42437653
Platypnoea 23.37 11.16 8 172362 32 42448933
Hypervolaemia 23.36 11.16 167 172203 22958 42426007
Hypersensitivity 23.31 11.16 184 172186 72186 42376779
Hypoglycaemia 23.30 11.16 144 172226 59710 42389255
Angiodysplasia 23.25 11.16 22 172348 785 42448180
Tachyarrhythmia 23.19 11.16 50 172320 3882 42445083
Tooth disorder 23.15 11.16 103 172267 11876 42437089
Hyperhidrosis 23.13 11.16 244 172126 90268 42358697
Low cardiac output syndrome 23.11 11.16 20 172350 634 42448331
Gastrointestinal polyp 23.08 11.16 10 172360 84 42448881
Peripheral artery stenosis 22.89 11.16 23 172347 884 42448081
Chest X-ray abnormal 22.87 11.16 54 172316 4454 42444511
Depressed mood 22.86 11.16 37 172333 23347 42425618
Toxic epidermal necrolysis 22.86 11.16 46 172324 26704 42422261
Hepatic haemorrhage 22.82 11.16 20 172350 645 42448320
Proteinuria 22.81 11.16 36 172334 22947 42426018
Haemophagocytic lymphohistiocytosis 22.78 11.16 24 172346 18198 42430767
Occult blood positive 22.70 11.16 52 172318 4205 42444760
Inability to afford medication 22.68 11.16 35 172335 2095 42446870
Injection site erythema 22.65 11.16 29 172341 20166 42428799
Prostatic haemorrhage 22.62 11.16 14 172356 260 42448705
Neurotoxicity 22.58 11.16 38 172332 23613 42425352
Spontaneous hyphaema 22.57 11.16 5 172365 0 42448965
Pulmonary hypertension 22.55 11.16 168 172202 23401 42425564
Bleeding time prolonged 22.48 11.16 20 172350 658 42448307
Varicophlebitis 22.23 11.16 7 172363 20 42448945
Prohormone brain natriuretic peptide increased 22.11 11.16 10 172360 94 42448871
Epstein-Barr virus infection 22.03 11.16 6 172364 9712 42439253
Bone pain 22.01 11.16 39 172331 23753 42425212
Arterial haemorrhage 21.99 11.16 26 172344 1203 42447762
Gout 21.95 11.16 191 172179 27864 42421101
Blindness 21.88 11.16 136 172234 17842 42431123
Diplopia 21.87 11.16 149 172221 20167 42428798
Traumatic haematoma 21.83 11.16 21 172349 765 42448200
Antiphospholipid syndrome 21.80 11.16 19 172351 608 42448357
Paranoia 21.78 11.16 15 172355 14011 42434954
Craniocerebral injury 21.75 11.16 48 172322 3786 42445179
Hepatotoxicity 21.74 11.16 43 172327 25124 42423841
Bronchopulmonary aspergillosis 21.69 11.16 28 172342 19401 42429564
Myasthenia gravis 21.61 11.16 20 172350 16117 42432848
Inappropriate schedule of product administration 21.58 11.16 266 172104 95636 42353329
Sinusitis 21.56 11.16 108 172262 47184 42401781
Haemarthrosis 21.50 11.16 49 172321 3949 42445016
Loss of personal independence in daily activities 21.34 11.16 301 172069 49515 42399450
Schizophrenia 21.28 11.16 8 172362 10542 42438423
Renal phospholipidosis 21.08 11.16 11 172359 145 42448820
Low birth weight baby 21.02 11.16 7 172363 9948 42439017
Hepatic failure 21.01 11.16 81 172289 38019 42410946
Hypercholesterolaemia 20.96 11.16 13 172357 12836 42436129
Platelet distribution width increased 20.75 11.16 11 172359 150 42448815
Blood bilirubin increased 20.72 11.16 94 172276 42158 42406807
Periorbital haematoma 20.68 11.16 15 172355 366 42448599
Cerebral artery occlusion 20.65 11.16 21 172349 819 42448146
Peritonitis 20.65 11.16 27 172343 18606 42430359
Transplant rejection 20.48 11.16 15 172355 13573 42435392
Haemorrhagic infarction 20.46 11.16 17 172353 509 42448456
Intentional overdose 20.44 11.16 123 172247 51333 42397632
Cardiac failure acute 20.43 11.16 109 172261 13524 42435441
Anastomotic infection 20.43 11.16 10 172360 114 42448851
Restlessness 20.43 11.16 56 172314 29193 42419772
Anaphylactic reaction 20.42 11.16 96 172274 42647 42406318
Hyperthyroidism 20.38 11.16 113 172257 14228 42434737
Blood pressure increased 20.28 11.16 290 172080 101638 42347327
White blood cell count decreased 20.27 11.16 319 172051 110077 42338888
Syncope 20.24 11.16 536 171834 98870 42350095
Anticoagulation drug level abnormal 20.19 11.16 11 172359 159 42448806
Mental disorder 20.11 11.16 26 172344 18003 42430962
Colon cancer 20.05 11.16 85 172285 9596 42439369
Disseminated intravascular coagulation 20.04 11.16 44 172326 24750 42424215
Xyphoid retraction 20.01 11.16 11 172359 162 42448803
Intercepted product preparation error 19.99 11.16 3 172367 7386 42441579
Splenic haematoma 19.83 11.16 11 172359 165 42448800
Dizziness postural 19.83 11.16 73 172297 7722 42441243
Acute vestibular syndrome 19.65 11.16 5 172365 4 42448961
Therapy change 19.64 11.16 48 172322 4047 42444918
Splenomegaly 19.62 11.16 24 172346 17023 42431942
Pancreatitis 19.61 11.16 99 172271 43169 42405796
Gastric ischaemia 19.59 11.16 8 172362 57 42448908
Benign gastrointestinal neoplasm 19.55 11.16 10 172360 126 42448839
Peripheral artery occlusion 19.44 11.16 30 172340 1796 42447169
Mitral valve calcification 19.43 11.16 18 172352 625 42448340
Vascular purpura 19.31 11.16 33 172337 2153 42446812
Subcapsular renal haematoma 19.27 11.16 17 172353 553 42448412
Increased appetite 19.27 11.16 6 172364 8900 42440065
Large intestinal haemorrhage 19.25 11.16 29 172341 1700 42447265
Infection 19.20 11.16 328 172042 111740 42337225
Aplasia pure red cell 19.18 11.16 3 172367 7163 42441802
Spinal epidural haematoma 19.15 11.16 15 172355 412 42448553
Metallosis of globe 19.13 11.16 5 172365 5 42448960
Hyperkaliuria 18.99 11.16 9 172361 95 42448870
Post procedural stroke 18.88 11.16 7 172363 37 42448928
Vasculitic rash 18.85 11.16 22 172348 1004 42447961
Helicobacter test false negative 18.80 11.16 8 172362 64 42448901
Bladder irrigation 18.80 11.16 8 172362 64 42448901
Anaphylactic shock 18.79 11.16 42 172328 23475 42425490
Brain oedema 18.78 11.16 23 172347 16304 42432661
Amyloidosis senile 18.67 11.16 9 172361 99 42448866
Inflammation 18.64 11.16 72 172298 33775 42415190
Hospice care 18.61 11.16 76 172294 8437 42440528
Kidney transplant rejection 18.52 11.16 6 172364 8677 42440288
Mucosal haemorrhage 18.49 11.16 29 172341 1761 42447204
C-reactive protein increased 18.49 11.16 166 172204 63394 42385571
Extradural haematoma 18.48 11.16 25 172345 1326 42447639
Normocytic anaemia 18.31 11.16 43 172327 3534 42445431
Pericardial drainage 18.28 11.16 9 172361 104 42448861
Oedema peripheral 18.07 11.16 697 171673 135379 42313586
Atrial appendage closure 18.06 11.16 4 172366 0 42448965
Clotting factor transfusion 18.06 11.16 4 172366 0 42448965
Procedure aborted 18.06 11.16 4 172366 0 42448965
Creatinine renal clearance decreased 18.03 11.16 43 172327 3570 42445395
Influenza like illness 18.01 11.16 67 172303 31773 42417192
Klebsiella infection 17.75 11.16 12 172358 11320 42437645
Swollen tongue 17.72 11.16 37 172333 21194 42427771
Inflammatory marker increased 17.70 11.16 3 172367 6753 42442212
Glomerular filtration rate decreased 17.65 11.16 120 172250 16231 42432734
Eosinophilic pleural effusion 17.61 11.16 13 172357 326 42448639
Sinus node dysfunction 17.60 11.16 51 172319 4761 42444204
Steroid dependence 17.58 11.16 3 172367 6719 42442246
Pulmonary fibrosis 17.54 11.16 175 172195 26506 42422459
Muscle twitching 17.53 11.16 94 172276 11686 42437279
Dyskinesia 17.44 11.16 49 172321 25341 42423624
Cellulitis gangrenous 17.42 11.16 12 172358 269 42448696
Hydrocephalus 17.24 11.16 59 172311 6019 42442946
Liver function test abnormal 17.14 11.16 70 172300 32321 42416644
Paradoxical embolism 17.12 11.16 5 172365 10 42448955
Mouth haemorrhage 17.09 11.16 60 172310 6201 42442764
Hepatic encephalopathy 17.04 11.16 25 172345 16417 42432548
Thinking abnormal 17.04 11.16 4 172366 7157 42441808
Aplastic anaemia 17.00 11.16 15 172355 12369 42436596
Nervous system disorder 17.00 11.16 27 172343 17168 42431797
Mucormycosis 16.98 11.16 4 172366 7139 42441826
Visual acuity reduced 16.94 11.16 28 172342 17522 42431443
Gastrostomy 16.92 11.16 20 172350 925 42448040
Blood alkaline phosphatase increased 16.92 11.16 74 172296 33523 42415442
Transcatheter aortic valve implantation 16.80 11.16 5 172365 11 42448954
Tumour haemorrhage 16.77 11.16 42 172328 3596 42445369
Rash papular 16.74 11.16 93 172277 11718 42437247
Asthma 16.67 11.16 349 172021 61965 42387000
Speech disorder 16.65 11.16 61 172309 29060 42419905
Euphoric mood 16.61 11.16 3 172367 6450 42442515
Stevens-Johnson syndrome 16.60 11.16 41 172329 22137 42426828
Constipation 16.51 11.16 515 171855 161776 42287189
Hypertension 16.43 11.16 533 171837 166671 42282294
Femoral artery aneurysm 16.38 11.16 10 172360 181 42448784
Prostatic adenoma 16.33 11.16 10 172360 182 42448783
Pneumocystis jirovecii pneumonia 16.28 11.16 50 172320 25131 42423834
Cytomegalovirus viraemia 16.24 11.16 11 172359 10366 42438599
Gingival pain 16.22 11.16 7 172363 8487 42440478
Respiratory tract haemorrhage 16.21 11.16 24 172346 1385 42447580
Metabolic acidosis 16.17 11.16 133 172237 51725 42397240
Orthostatic hypotension 16.16 11.16 192 172178 30378 42418587
Tendonitis 16.15 11.16 10 172360 9884 42439081
Muscle rigidity 16.09 11.16 15 172355 12044 42436921
Blood immunoglobulin M abnormal 16.06 11.16 8 172362 95 42448870
Lupus pneumonitis 16.03 11.16 7 172363 60 42448905
Vascular cauterisation 15.99 11.16 6 172364 33 42448932
Face oedema 15.99 11.16 19 172351 13647 42435318
Ear infection 15.85 11.16 17 172353 12787 42436178
Thrombectomy 15.84 11.16 8 172362 98 42448867
Hypoaesthesia 15.78 11.16 199 172171 71264 42377701
Haemostasis 15.77 11.16 9 172361 143 42448822
Skin pressure mark 15.74 11.16 7 172363 63 42448902
Mood swings 15.73 11.16 8 172362 8818 42440147
Hypogammaglobulinaemia 15.62 11.16 15 172355 11876 42437089
Neuropathy peripheral 15.60 11.16 304 172066 101549 42347416
Intracardiac thrombus 15.59 11.16 32 172338 2400 42446565
Amaurosis fugax 15.58 11.16 17 172353 720 42448245
Skull fracture 15.58 11.16 20 172350 1008 42447957
Abnormal loss of weight 15.57 11.16 50 172320 4937 42444028
Traumatic intracranial haematoma 15.56 11.16 6 172364 36 42448929
Oesophageal carcinoma 15.55 11.16 10 172360 9686 42439279
Hypoacusis 15.52 11.16 129 172241 18573 42430392
Catheter management 15.51 11.16 20 172350 1012 42447953
Left atrial enlargement 15.47 11.16 20 172350 1015 42447950
Tuberculosis 15.42 11.16 11 172359 10088 42438877
Catheter site pruritus 15.37 11.16 12 172358 328 42448637
Pneumonia fungal 15.27 11.16 9 172361 9137 42439828
Spinal subdural haematoma 15.19 11.16 7 172363 69 42448896
Disease recurrence 15.17 11.16 65 172305 29613 42419352
Anti factor X activity increased 15.16 11.16 8 172362 108 42448857
Ilium fracture 15.13 11.16 9 172361 155 42448810
Drug level fluctuating 15.04 11.16 16 172354 658 42448307
Forced expiratory volume decreased 15.04 11.16 66 172304 7564 42441401
Putamen haemorrhage 15.04 11.16 11 172359 272 42448693
Gastric antral vascular ectasia 14.92 11.16 13 172357 416 42448549
Product complaint 14.91 11.16 3 172367 5974 42442991
Coma uraemic 14.90 11.16 6 172364 41 42448924
Affective disorder 14.85 11.16 3 172367 5957 42443008
Oral candidiasis 14.84 11.16 22 172348 14383 42434582
Ankylosing spondylitis 14.83 11.16 5 172365 7051 42441914
Drug eruption 14.79 11.16 46 172324 23029 42425936
Lung infiltration 14.77 11.16 21 172349 13968 42434997
Cardiogenic shock 14.73 11.16 214 172156 35426 42413539
Injection site swelling 14.66 11.16 29 172341 16944 42432021
Ear haemorrhage 14.60 11.16 20 172350 1074 42447891
Maternal exposure during pregnancy 14.57 11.16 5 172365 6973 42441992
Contraindicated product prescribed 14.56 11.16 16 172354 683 42448282
Lymphopenia 14.53 11.16 42 172328 21521 42427444
Conjunctival haemorrhage 14.45 11.16 39 172331 3494 42445471
Tricuspid valve disease 14.45 11.16 10 172360 226 42448739
Priapism 14.44 11.16 4 172366 6403 42442562
Hyperkinetic heart syndrome 14.42 11.16 8 172362 120 42448845
Nipple exudate bloody 14.42 11.16 4 172366 6 42448959
Sticky platelet syndrome 14.41 11.16 5 172365 21 42448944
Radiation fibrosis - lung 14.41 11.16 5 172365 21 42448944
Chloasma 14.41 11.16 5 172365 21 42448944
Product monitoring error 14.41 11.16 45 172325 4378 42444587
Tardive dyskinesia 14.39 11.16 5 172365 6919 42442046
Pharyngeal haemorrhage 14.37 11.16 17 172353 787 42448178
Erectile dysfunction 14.37 11.16 52 172318 24861 42424104
Subdural hygroma 14.33 11.16 13 172357 439 42448526
Puncture site haematoma 14.32 11.16 9 172361 172 42448793
Pharyngeal haematoma 14.29 11.16 7 172363 80 42448885
Prostatectomy 14.24 11.16 11 172359 296 42448669
Central nervous system lesion 14.23 11.16 7 172363 7863 42441102
Rash 14.21 11.16 947 171423 276007 42172958
Hepatomegaly 14.20 11.16 16 172354 11769 42437196
Methaemoglobinaemia 14.20 11.16 3 172367 5771 42443194
Aortic aneurysm rupture 14.19 11.16 20 172350 1103 42447862
Asphyxia 14.18 11.16 8 172362 8318 42440647
Visual impairment 14.10 11.16 249 172121 42864 42406101
Subdural haematoma evacuation 14.05 11.16 5 172365 23 42448942
Vision blurred 14.02 11.16 144 172226 53555 42395410
Gastroduodenal haemorrhage 14.00 11.16 9 172361 179 42448786
Swelling 14.00 11.16 148 172222 54737 42394228
Hypercoagulation 13.96 11.16 23 172347 1456 42447509
Infarction 13.95 11.16 35 172335 3000 42445965
Pseudomonas infection 13.93 11.16 27 172343 15896 42433069
Body temperature decreased 13.91 11.16 23 172347 14390 42434575
Thrombotic microangiopathy 13.88 11.16 24 172346 14758 42434207
Myeloblast count increased 13.88 11.16 5 172365 24 42448941
Calculus bladder 13.88 11.16 22 172348 1348 42447617
Pituitary apoplexy 13.86 11.16 8 172362 130 42448835
Dementia 13.85 11.16 114 172256 16366 42432599
Rectal ulcer haemorrhage 13.84 11.16 7 172363 86 42448879
Intentional product misuse 13.80 11.16 172 172198 61728 42387237
Exostosis 13.69 11.16 3 172367 5628 42443337
Cerebral artery embolism 13.67 11.16 19 172351 1034 42447931
Therapeutic response shortened 13.67 11.16 21 172349 13533 42435432
Parosmia 13.67 11.16 7 172363 7684 42441281
Intentional underdose 13.64 11.16 16 172354 734 42448231
Intestinal haemorrhage 13.62 11.16 41 172329 3910 42445055
Circumstance or information capable of leading to medication error 13.61 11.16 31 172339 2497 42446468
Drug interaction 13.59 11.16 1255 171115 265744 42183221
Hepatic enzyme increased 13.56 11.16 119 172251 45665 42403300
Factor Xa activity increased 13.54 11.16 3 172367 0 42448965
Intestinal varices haemorrhage 13.54 11.16 3 172367 0 42448965
Hepatic enzyme 13.54 11.16 3 172367 0 42448965
Therapeutic aspiration 13.54 11.16 3 172367 0 42448965
Oesophagogastroduodenoscopy abnormal 13.54 11.16 3 172367 0 42448965
Anal ulcer haemorrhage 13.54 11.16 3 172367 0 42448965
Femoral artery embolism 13.54 11.16 3 172367 0 42448965
Mallory-Weiss syndrome 13.49 11.16 23 172347 1498 42447467
Spinal cord infarction 13.45 11.16 15 172355 651 42448314
Renal injury 13.40 11.16 18 172352 12262 42436703
Prostatic disorder 13.40 11.16 39 172331 3650 42445315
Impaired quality of life 13.33 11.16 23 172347 14154 42434811
Mast cell activation syndrome 13.31 11.16 11 172359 327 42448638
Condition aggravated 13.30 11.16 892 171478 259862 42189103
Salivary gland enlargement 13.30 11.16 6 172364 56 42448909
Cognitive disorder 13.27 11.16 203 172167 33969 42414996
Acute hepatic failure 13.23 11.16 31 172339 17042 42431923
Fracture delayed union 13.21 11.16 6 172364 57 42448908
Wound haematoma 13.21 11.16 6 172364 57 42448908
Blood calcium increased 13.18 11.16 9 172361 8445 42440520
Gynaecomastia 13.13 11.16 19 172351 12548 42436417
Pulmonary haemorrhage 13.12 11.16 85 172285 11312 42437653
Subcutaneous haematoma 13.10 11.16 19 172351 1076 42447889
Salivary hypersecretion 13.03 11.16 15 172355 10928 42438037
Coma 13.02 11.16 146 172224 53408 42395557
Hypothyroidism 13.00 11.16 192 172178 31892 42417073
Renal oncocytoma 12.98 11.16 9 172361 204 42448761
Splinter haemorrhages 12.98 11.16 7 172363 99 42448866
C-reactive protein abnormal 12.98 11.16 11 172359 9250 42439715
Orbital haemorrhage 12.96 11.16 5 172365 30 42448935
Cardiorenal syndrome 12.95 11.16 17 172353 876 42448089
Oesophageal infection 12.94 11.16 11 172359 340 42448625
Increased tendency to bruise 12.91 11.16 43 172327 4327 42444638
Peptic ulcer haemorrhage 12.90 11.16 15 172355 682 42448283
Gastrointestinal polyp haemorrhage 12.89 11.16 13 172357 502 42448463
Hip fracture 12.87 11.16 96 172274 13376 42435589
Device pacing issue 12.86 11.16 6 172364 61 42448904
Electrocardiogram ST segment elevation 12.85 11.16 4 172366 5935 42443030
Disease prodromal stage 12.83 11.16 5 172365 31 42448934
Hypopnoea 12.82 11.16 8 172362 7874 42441091
Restless legs syndrome 12.78 11.16 12 172358 9602 42439363
Hyperammonaemia 12.77 11.16 8 172362 7858 42441107
Body temperature increased 12.75 11.16 41 172329 20317 42428648
Respiratory distress 12.70 11.16 108 172262 41712 42407253
Lower respiratory tract infection 12.70 11.16 106 172264 41100 42407865
Overflow diarrhoea 12.69 11.16 6 172364 63 42448902
Drug dose omission by device 12.67 11.16 4 172366 5882 42443083
Joint swelling 12.67 11.16 196 172174 67826 42381139
Rhinitis 12.62 11.16 18 172352 11959 42437006
Abdominal distension 12.59 11.16 209 172161 71526 42377439
Endocarditis noninfective 12.58 11.16 8 172362 156 42448809
Incision site haematoma 12.56 11.16 7 172363 106 42448859
Large intestine perforation 12.56 11.16 12 172358 9524 42439441
Eosinophil count increased 12.55 11.16 15 172355 10748 42438217
Cystitis haemorrhagic 12.54 11.16 7 172363 7322 42441643
Palmar-plantar erythrodysaesthesia syndrome 12.51 11.16 42 172328 20540 42428425
Creatinine renal clearance abnormal 12.47 11.16 11 172359 358 42448607
Bleeding varicose vein 12.44 11.16 11 172359 359 42448606
Product use issue 12.39 11.16 227 172143 76524 42372441
Oesophageal achalasia 12.36 11.16 12 172358 442 42448523
Bladder neoplasm 12.34 11.16 22 172348 1485 42447480
Ventricular drainage 12.32 11.16 4 172366 13 42448952
Intercepted product prescribing error 12.32 11.16 8 172362 162 42448803
Odynophagia 12.27 11.16 6 172364 6764 42442201
Osteopenia 12.27 11.16 5 172365 6273 42442692
Blood urea increased 12.19 11.16 80 172290 32713 42416252
Syringe issue 12.19 11.16 10 172360 8546 42440419
Photophobia 12.19 11.16 9 172361 8110 42440855
Staphylococcal sepsis 12.18 11.16 17 172353 11397 42437568
Wrong patient received product 12.18 11.16 37 172333 3546 42445419
Sleep disorder 12.14 11.16 130 172240 47965 42401000
Embolism venous 12.12 11.16 25 172345 1881 42447084
Ileus paralytic 12.09 11.16 8 172362 7633 42441332
Hepatitis B 12.09 11.16 6 172364 6705 42442260
Thromboembolectomy 12.08 11.16 5 172365 37 42448928
Amaurosis 12.06 11.16 16 172354 833 42448132
Bronchospasm 12.03 11.16 21 172349 12864 42436101
Catheter site irritation 12.01 11.16 7 172363 116 42448849
Aortic thrombosis 11.99 11.16 18 172352 1052 42447913
Herpes zoster 11.98 11.16 100 172270 38777 42410188
Hepatic cancer 11.97 11.16 10 172360 8470 42440495
Treatment delayed 11.94 11.16 8 172362 171 42448794
Infusion site erythema 11.93 11.16 37 172333 3585 42445380
Pharyngitis 11.93 11.16 11 172359 8879 42440086
Gastritis haemorrhagic 11.90 11.16 23 172347 1651 42447314
Herpes simplex 11.82 11.16 7 172363 7088 42441877
Laryngeal discomfort 11.82 11.16 9 172361 237 42448728
Mitral valve thickening 11.80 11.16 12 172358 468 42448497
Colitis ulcerative 11.80 11.16 60 172310 26115 42422850
Uveitis 11.79 11.16 12 172358 9246 42439719
Arthritis 11.74 11.16 111 172259 41954 42407011
Hyperlipidaemia 11.70 11.16 46 172324 21470 42427495
Urinary retention postoperative 11.67 11.16 8 172362 178 42448787
Occult blood 11.64 11.16 17 172353 969 42447996
Catheterisation cardiac 11.59 11.16 31 172339 2763 42446202
Skin toxicity 11.58 11.16 6 172364 6543 42442422
Myelodysplastic syndrome 11.51 11.16 50 172320 22695 42426270
Gastric polyps 11.51 11.16 23 172347 1692 42447273
Haemorrhagic vasculitis 11.48 11.16 3 172367 3 42448962
Blood pressure systolic abnormal 11.47 11.16 4 172366 5524 42443441
Haemorrhagic cerebral infarction 11.46 11.16 16 172354 875 42448090
Mood altered 11.40 11.16 16 172354 10702 42438263
Toxic encephalopathy 11.39 11.16 7 172363 6946 42442019
Decreased appetite 11.36 11.16 652 171718 192485 42256480
Infection parasitic 11.32 11.16 11 172359 406 42448559
Confusional state 11.31 11.16 558 171812 167039 42281926
Brain herniation 11.30 11.16 44 172326 4779 42444186
Cardiac valve disease 11.26 11.16 35 172335 3396 42445569
Cardio-respiratory arrest 11.25 11.16 168 172202 58468 42390497
Blood testosterone decreased 11.16 11.16 3 172367 4899 42444066

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 2670.87 10.32 6006 306842 692863 109583588
Gastrointestinal haemorrhage 2452.36 10.32 2669 310179 162849 110113602
Atrial fibrillation 2193.23 10.32 2964 309884 226678 110049773
Cerebral haemorrhage 1810.52 10.32 1488 311360 63480 110212971
Haemorrhage 1689.33 10.32 1783 311065 104909 110171542
Haemorrhage intracranial 1165.29 10.32 826 312022 28143 110248308
Fall 1063.62 10.32 3932 308916 599550 109676901
Subdural haematoma 1011.19 10.32 833 312015 35621 110240830
Anaemia 992.67 10.32 3599 309249 543487 109732964
Cerebrovascular accident 980.59 10.32 1804 311044 179480 110096971
Melaena 910.99 10.32 1047 311801 67710 110208741
Haematoma 878.71 10.32 951 311897 57525 110218926
Subarachnoid haemorrhage 797.31 10.32 666 312182 29036 110247415
Cardiac failure 786.29 10.32 1678 311170 185948 110090503
Epistaxis 756.52 10.32 1338 311510 129034 110147417
Thrombosis 752.57 10.32 1207 311641 107455 110168996
Haematuria 745.05 10.32 1041 311807 81964 110194487
Synovitis 698.22 10.32 16 312832 274076 110002375
Drug ineffective 677.10 10.32 2137 310711 1518403 108758048
Gastric haemorrhage 675.39 10.32 469 312379 15446 110261005
Hand deformity 589.65 10.32 5 312843 218501 110057950
Infusion related reaction 564.92 10.32 187 312661 380975 109895476
Ischaemic stroke 564.49 10.32 639 312209 40624 110235827
Drug hypersensitivity 558.62 10.32 294 312554 453796 109822655
Pemphigus 544.60 10.32 13 312835 214557 110061894
Dyspnoea 511.58 10.32 5072 307776 1101800 109174651
Cerebral infarction 507.20 10.32 678 312170 51160 110225291
Pulmonary embolism 500.70 10.32 1538 311310 212936 110063515
Glossodynia 498.38 10.32 33 312815 221971 110054480
Maternal exposure during pregnancy 497.92 10.32 66 312782 254817 110021634
Prescribed underdose 497.09 10.32 757 312091 64417 110212034
Pericardial haemorrhage 480.77 10.32 253 312595 4964 110271487
Haemoglobin decreased 475.96 10.32 1667 311181 247060 110029391
Duodenal ulcer perforation 475.04 10.32 5 312843 177695 110098756
Systemic lupus erythematosus 473.33 10.32 76 312772 254262 110022189
Shock haemorrhagic 466.11 10.32 475 312373 26772 110249679
Drug intolerance 452.08 10.32 297 312551 406215 109870236
Rheumatoid arthritis 421.58 10.32 160 312688 299453 109976998
Exposure during pregnancy 421.58 10.32 11 312837 167413 110109038
Hospitalisation 421.30 10.32 1113 311735 141380 110135071
Upper gastrointestinal haemorrhage 419.52 10.32 608 312240 49488 110226963
Helicobacter infection 411.28 10.32 26 312822 181851 110094600
Therapeutic product effect decreased 408.19 10.32 95 312753 244221 110032230
Folliculitis 404.39 10.32 16 312832 167637 110108814
Joint swelling 403.03 10.32 395 312453 442450 109834001
Acute kidney injury 400.74 10.32 3120 309728 632310 109644141
Haematochezia 390.10 10.32 949 311899 114575 110161876
Blood cholesterol increased 385.50 10.32 38 312810 184747 110091704
Hepatic enzyme increased 375.30 10.32 221 312627 320671 109955780
Renal impairment 373.41 10.32 1278 311570 187167 110089284
Cardiac disorder 372.24 10.32 727 312121 75553 110200898
Muscle injury 367.40 10.32 6 312842 140801 110135650
Transfusion 362.98 10.32 403 312445 25069 110251382
Psoriatic arthropathy 352.42 10.32 65 312783 196696 110079755
Hypersensitivity 348.70 10.32 377 312471 403621 109872830
Stomatitis 345.55 10.32 166 312682 270076 110006375
Hypotension 332.67 10.32 2577 310271 521272 109755179
Irritable bowel syndrome 329.22 10.32 39 312809 164176 110112275
Lower gastrointestinal haemorrhage 326.66 10.32 328 312520 18158 110258293
Transient ischaemic attack 323.44 10.32 619 312229 63363 110213088
Impaired healing 319.75 10.32 81 312767 196636 110079815
Musculoskeletal stiffness 317.01 10.32 200 312648 279622 109996829
Haemoptysis 309.96 10.32 648 312200 70706 110205745
Arthropathy 298.50 10.32 226 312622 287296 109989155
Haemorrhagic stroke 291.45 10.32 270 312578 13519 110262932
Pain 288.63 10.32 1557 311291 953398 109323053
Atrial thrombosis 286.24 10.32 169 312679 4177 110272274
C-reactive protein abnormal 283.18 10.32 22 312826 129673 110146778
Labelled drug-drug interaction medication error 281.63 10.32 380 312468 28922 110247529
Haematemesis 279.49 10.32 556 312292 58552 110217899
Swelling 274.57 10.32 354 312494 350687 109925764
Cerebral haematoma 266.81 10.32 220 312628 9412 110267039
Bradycardia 266.51 10.32 1006 311842 154511 110121940
Atrial flutter 263.25 10.32 334 312514 23928 110252523
Lower respiratory tract infection 257.60 10.32 187 312661 242919 110033532
Sinusitis 255.74 10.32 277 312571 296411 109980040
Cardiospasm 255.52 10.32 165 312683 4802 110271649
Joint range of motion decreased 251.62 10.32 26 312822 121806 110154645
Blister 251.39 10.32 167 312681 227209 110049242
Embolic stroke 251.22 10.32 204 312644 8539 110267912
Type 2 diabetes mellitus 248.61 10.32 95 312753 177137 110099314
Lip dry 246.72 10.32 8 312840 100075 110176376
Post procedural haemorrhage 246.54 10.32 260 312588 15252 110261199
Dyspnoea exertional 246.12 10.32 750 312098 103310 110173141
Palmoplantar keratoderma 245.70 10.32 166 312682 5221 110271230
Bursitis 243.47 10.32 38 312810 129880 110146571
Ill-defined disorder 242.84 10.32 71 312777 156782 110119669
Atrial tachycardia 238.43 10.32 202 312646 8976 110267475
Product prescribing error 238.08 10.32 479 312369 50852 110225599
Nasopharyngitis 235.70 10.32 475 312373 393886 109882565
Pulmonary alveolar haemorrhage 235.61 10.32 288 312560 19862 110256589
Intraventricular haemorrhage 235.31 10.32 163 312685 5344 110271107
Rectal haemorrhage 233.15 10.32 808 312040 119025 110157426
Head injury 229.60 10.32 426 312422 42591 110233860
Deep vein thrombosis 224.22 10.32 886 311962 139001 110137450
Wound 221.40 10.32 202 312646 234235 110042216
Carotid artery occlusion 221.19 10.32 197 312651 9368 110267083
Injury 220.32 10.32 113 312735 177152 110099299
Drug abuse 217.68 10.32 115 312733 177296 110099155
Vasculitis 211.53 10.32 371 312477 35502 110240949
Sleep terror 210.84 10.32 164 312684 6446 110270005
Pruritus genital 210.61 10.32 163 312685 6359 110270092
Cardiac amyloidosis 209.93 10.32 119 312729 2718 110273733
Completed suicide 209.18 10.32 226 312622 242155 110034296
Treatment failure 208.15 10.32 288 312560 276946 109999505
Haematoma muscle 203.37 10.32 133 312715 3957 110272494
Discomfort 202.74 10.32 185 312663 214522 110061929
Toxicity to various agents 201.57 10.32 691 312157 479864 109796587
Urticaria 195.70 10.32 378 312470 318479 109957972
Traumatic intracranial haemorrhage 193.62 10.32 91 312757 1385 110275066
Internal haemorrhage 193.38 10.32 187 312661 9884 110266567
Drug interaction 193.18 10.32 2214 310634 497969 109778482
Grip strength decreased 192.13 10.32 8 312840 80166 110196285
Mobility decreased 190.17 10.32 235 312613 237187 110039264
Arrhythmia 190.03 10.32 528 312320 69047 110207404
Inflammation 189.08 10.32 161 312687 193077 110083374
Blood loss anaemia 184.36 10.32 241 312607 17784 110258667
Cardioversion 184.29 10.32 102 312746 2221 110274230
Sensitisation 182.40 10.32 125 312723 4026 110272425
Hypoaesthesia 182.17 10.32 385 312463 313838 109962613
Tension headache 181.70 10.32 177 312671 9441 110267010
Arthralgia 181.45 10.32 1376 311472 778256 109498195
Live birth 177.05 10.32 4 312844 69480 110206971
Spirometry abnormal 176.67 10.32 137 312711 5360 110271091
Diverticulum intestinal haemorrhagic 175.91 10.32 129 312719 4634 110271817
Sleep disorder due to general medical condition, insomnia type 174.55 10.32 42 312806 105601 110170850
Mite allergy 174.37 10.32 139 312709 5664 110270787
Immunisation 171.83 10.32 109 312739 3074 110273377
Subdural haemorrhage 171.72 10.32 145 312703 6413 110270038
Hypercholesterolaemia 171.49 10.32 26 312822 90811 110185640
Depression 170.74 10.32 405 312443 316930 109959521
Pulmonary arterial hypertension 170.65 10.32 320 312528 32248 110244203
Syncope 169.80 10.32 1067 311781 201469 110074982
Alopecia 167.17 10.32 504 312344 364249 109912202
Liver injury 166.86 10.32 110 312738 150303 110126148
Polycystic ovaries 166.17 10.32 125 312723 4671 110271780
Intentional product use issue 164.49 10.32 1233 311615 246673 110029778
Dry mouth 163.19 10.32 195 312653 199753 110076698
Conjunctivitis allergic 162.76 10.32 144 312704 6787 110269664
Cerebral mass effect 159.14 10.32 94 312754 2325 110274126
Pyrexia 156.08 10.32 1707 311141 896558 109379893
Infection 155.77 10.32 515 312333 361685 109914766
Sleep disorder 155.54 10.32 200 312648 198444 110078007
Gastrointestinal disorder 152.67 10.32 282 312566 241670 110034781
Pericarditis 152.36 10.32 240 312608 218874 110057577
C-reactive protein increased 152.19 10.32 238 312610 217681 110058770
Injection site reaction 151.97 10.32 33 312815 89037 110187414
Dust allergy 151.64 10.32 130 312718 5871 110270580
Mycotic allergy 150.49 10.32 129 312719 5825 110270626
Ejection fraction 149.15 10.32 97 312751 2858 110273593
COVID-19 147.16 10.32 1191 311657 243869 110032582
Anosmia 147.01 10.32 179 312669 12293 110264158
Cardiac failure congestive 146.10 10.32 826 312022 150174 110126277
Deep vein thrombosis postoperative 145.21 10.32 5 312843 59286 110217165
Fibromyalgia 144.52 10.32 162 312686 170747 110105704
Thalamus haemorrhage 144.30 10.32 82 312766 1882 110274569
Abdominal wall haematoma 140.94 10.32 122 312726 5583 110270868
Blepharospasm 140.37 10.32 3 312845 54848 110221603
Faeces discoloured 140.11 10.32 302 312546 33646 110242805
Wound infection 139.83 10.32 49 312799 96416 110180035
Traumatic haemorrhage 138.21 10.32 78 312770 1766 110274685
Cardiac ablation 137.73 10.32 89 312759 2593 110273858
Haemothorax 137.73 10.32 132 312716 6899 110269552
Fluid retention 133.49 10.32 575 312273 93732 110182719
Cerebellar haemorrhage 133.19 10.32 94 312754 3177 110273274
Cutaneous vasculitis 133.00 10.32 172 312676 12557 110263894
Full blood count abnormal 131.57 10.32 403 312445 55649 110220802
Rash 131.26 10.32 1589 311259 819375 109457076
Systemic infection 129.08 10.32 149 312699 9670 110266781
Product use in unapproved indication 128.92 10.32 740 312108 446637 109829814
Contraindicated product administered 128.67 10.32 323 312525 247944 110028507
Facial pain 128.14 10.32 186 312662 15153 110261298
Haemorrhage subcutaneous 123.97 10.32 112 312736 5427 110271024
Nail disorder 123.22 10.32 11 312837 57924 110218527
Peripheral venous disease 121.45 10.32 43 312805 84074 110192377
Osteoarthritis 121.38 10.32 206 312642 182417 110094034
Product use issue 120.14 10.32 464 312384 311231 109965220
Dizziness 120.04 10.32 2700 310148 695493 109580958
Night sweats 118.84 10.32 122 312726 133861 110142590
Traumatic haematoma 118.60 10.32 78 312770 2343 110274108
Cardiac tamponade 118.47 10.32 153 312695 11154 110265297
Cerebral ventricular rupture 117.87 10.32 46 312802 429 110276022
Cardiac pacemaker insertion 117.24 10.32 115 312733 6186 110270265
Adrenal haemorrhage 115.65 10.32 53 312795 759 110275692
Obesity 115.13 10.32 91 312757 113260 110163191
Onychomadesis 114.92 10.32 3 312845 45660 110230791
Injection site pain 114.33 10.32 205 312643 177717 110098734
Pericardial effusion 114.03 10.32 389 312459 56828 110219623
Basal ganglia haemorrhage 112.90 10.32 69 312779 1819 110274632
Pulmonary hypertension 112.32 10.32 378 312470 54842 110221609
Ventricular tachycardia 112.23 10.32 354 312494 49655 110226796
Therapeutic response decreased 111.94 10.32 67 312781 96432 110180019
Pulmonary vasculitis 109.71 10.32 113 312735 6447 110270004
Duodenal ulcer 108.86 10.32 197 312651 19317 110257134
Oedema peripheral 108.54 10.32 1413 311435 327247 109949204
Product quality issue 107.43 10.32 42 312806 77257 110199194
Spontaneous haematoma 105.47 10.32 67 312781 1894 110274557
Psoriasis 105.44 10.32 145 312703 139848 110136603
Renal disorder 105.36 10.32 344 312504 49135 110227316
Hypothyroidism 105.11 10.32 447 312401 72452 110203999
Cardiac failure chronic 104.66 10.32 160 312688 13651 110262800
Hypervolaemia 104.54 10.32 343 312505 49117 110227334
Red blood cell sedimentation rate increased 101.69 10.32 47 312801 78255 110198196
Haemoperitoneum 101.49 10.32 99 312749 5289 110271162
Abdominal discomfort 100.71 10.32 676 312172 393182 109883269
Autoimmune disorder 100.67 10.32 30 312818 65453 110210998
Myelosuppression 100.61 10.32 72 312776 94268 110182183
Retroperitoneal haematoma 99.64 10.32 104 312744 6027 110270424
Haemarthrosis 99.36 10.32 113 312735 7216 110269235
Normochromic normocytic anaemia 98.58 10.32 151 312697 12906 110263545
Vascular pseudoaneurysm 98.28 10.32 87 312761 4103 110272348
Dementia 98.23 10.32 252 312596 31421 110245030
Gait inability 98.02 10.32 146 312702 136230 110140221
BRASH syndrome 96.83 10.32 82 312766 3641 110272810
Pain of skin 96.58 10.32 190 312658 19839 110256612
Blindness 95.41 10.32 272 312576 36087 110240364
Exostosis 94.38 10.32 10 312838 45946 110230505
Haemorrhoidal haemorrhage 93.52 10.32 115 312733 7978 110268473
Sleep disorder due to a general medical condition 92.44 10.32 341 312507 51771 110224680
Post procedural haematoma 91.92 10.32 69 312779 2570 110273881
Right atrial hypertrophy 91.87 10.32 43 312805 648 110275803
Therapeutic drug monitoring analysis not performed 91.66 10.32 61 312787 1870 110274581
Dehydration 91.55 10.32 1200 311648 278311 109998140
Spinal cord haemorrhage 90.74 10.32 41 312807 567 110275884
N-terminal prohormone brain natriuretic peptide increased 89.19 10.32 98 312750 6023 110270428
Palpitations 88.70 10.32 761 312087 158451 110118000
Muscle haemorrhage 88.23 10.32 103 312745 6766 110269685
Muscle spasticity 88.05 10.32 3 312845 35912 110240539
Sciatica 87.91 10.32 79 312769 92320 110184131
Interstitial lung disease 87.87 10.32 685 312163 138649 110137802
Therapy interrupted 87.53 10.32 325 312523 49497 110226954
Vomiting 87.48 10.32 1937 310911 908738 109367713
Treatment noncompliance 86.92 10.32 423 312425 72567 110203884
Liver disorder 86.87 10.32 169 312679 142074 110134377
Mixed liver injury 86.04 10.32 136 312712 11943 110264508
Paraesthesia 85.85 10.32 446 312402 276075 110000376
Splenic rupture 85.35 10.32 66 312782 2571 110273880
Iron deficiency anaemia 83.70 10.32 237 312611 31322 110245129
Ejection fraction abnormal 83.47 10.32 73 312775 3387 110273064
Drug resistance 82.79 10.32 28 312820 56346 110220105
Incorrect route of product administration 82.35 10.32 39 312809 64022 110212429
Aortic valve stenosis 81.20 10.32 95 312753 6255 110270196
Wrong patient received product 80.64 10.32 97 312751 6577 110269874
Human rhinovirus test positive 80.48 10.32 48 312800 1209 110275242
Sinus node dysfunction 80.42 10.32 113 312735 8934 110267517
Onychomycosis 80.12 10.32 8 312840 38523 110237928
Neuritis 78.90 10.32 101 312747 7298 110269153
Gastric ulcer 78.68 10.32 270 312578 39557 110236894
Alanine aminotransferase increased 78.45 10.32 262 312586 183511 110092940
Haemorrhagic cholecystitis 78.38 10.32 26 312822 143 110276308
Weight increased 78.12 10.32 784 312064 418860 109857591
Coeliac disease 77.86 10.32 14 312834 43173 110233278
Cytomegalovirus infection 76.62 10.32 29 312819 54415 110222036
Anticoagulant-related nephropathy 76.52 10.32 27 312821 184 110276267
Retroperitoneal haemorrhage 76.33 10.32 90 312758 5975 110270476
Gastrointestinal angiodysplasia 75.97 10.32 46 312802 1192 110275259
Procedural haemorrhage 75.83 10.32 85 312763 5342 110271109
Mouth haemorrhage 75.02 10.32 136 312712 13352 110263099
Febrile neutropenia 74.92 10.32 556 312292 316211 109960240
Injection site erythema 74.54 10.32 94 312754 94082 110182369
Urinary bladder haemorrhage 73.08 10.32 62 312786 2760 110273691
Lower limb fracture 72.19 10.32 64 312784 75284 110201167
Arthritis 71.48 10.32 239 312609 167347 110109104
Total lung capacity abnormal 71.38 10.32 76 312772 4507 110271944
Haemorrhagic disorder 71.28 10.32 51 312797 1762 110274689
Carpal tunnel syndrome 71.26 10.32 181 312667 22429 110254022
Catheter site haemorrhage 70.29 10.32 85 312763 5795 110270656
Failure to suspend medication 70.09 10.32 32 312816 454 110275997
Dyspepsia 69.91 10.32 290 312558 190675 110085776
Ear infection 69.39 10.32 46 312802 62686 110213765
Muscle spasms 69.28 10.32 481 312367 277676 109998775
Hyperkalaemia 68.90 10.32 636 312212 135160 110141291
Joint stiffness 68.26 10.32 54 312794 67189 110209262
Respiratory syncytial virus test positive 68.05 10.32 46 312802 1448 110275003
Pulmonary thrombosis 67.44 10.32 132 312716 13731 110262720
Therapy non-responder 67.32 10.32 224 312624 157083 110119368
Mucosal inflammation 67.09 10.32 105 312743 96036 110180415
Mesenteric haematoma 66.88 10.32 20 312828 73 110276378
Right ventricular hypertrophy 66.77 10.32 48 312800 1671 110274780
Drug dependence 66.56 10.32 29 312819 49991 110226460
Foot deformity 66.29 10.32 27 312821 48453 110227998
Seizure 65.72 10.32 362 312486 220823 110055628
Aspartate aminotransferase increased 65.56 10.32 232 312616 159704 110116747
Hypovolaemic shock 65.13 10.32 134 312714 14449 110262002
Cardiac failure acute 65.01 10.32 182 312666 23896 110252555
Arteriosclerosis 63.74 10.32 184 312664 24583 110251868
Road traffic accident 63.51 10.32 130 312718 107268 110169183
Blood urine present 63.25 10.32 181 312667 24064 110252387
Erythema 63.12 10.32 524 312324 290923 109985528
Arteriosclerosis coronary artery 63.10 10.32 185 312663 24933 110251518
Ear pain 63.08 10.32 36 312812 53190 110223261
Large intestine polyp 62.97 10.32 135 312713 14982 110261469
Emotional distress 62.92 10.32 24 312824 44823 110231628
Stress 62.74 10.32 127 312721 105221 110171230
Multiple sclerosis relapse 62.43 10.32 32 312816 50208 110226243
Nephrectomy 62.29 10.32 55 312793 2585 110273866
Diplopia 62.03 10.32 259 312589 41635 110234816
Brain stem haemorrhage 61.95 10.32 47 312801 1779 110274672
Malignant mediastinal neoplasm 61.74 10.32 42 312806 1336 110275115
Musculoskeletal pain 61.51 10.32 287 312561 182736 110093715
Eosinophilic granulomatosis with polyangiitis 61.03 10.32 109 312739 10577 110265874
Serotonin syndrome 60.68 10.32 47 312801 59106 110217345
Hip arthroplasty 60.29 10.32 42 312806 55771 110220680
Haematoma evacuation 60.04 10.32 27 312821 369 110276082
Heart rate increased 59.13 10.32 645 312203 143189 110133262
Sedation 58.94 10.32 66 312782 69617 110206834
Anticoagulation drug level increased 58.90 10.32 36 312812 949 110275502
Lupus-like syndrome 58.63 10.32 21 312827 40771 110235680
Pleural effusion 58.59 10.32 764 312084 176945 110099506
High frequency ablation 58.57 10.32 26 312822 344 110276107
Blood test abnormal 58.54 10.32 196 312652 28358 110248093
Thrombectomy 58.04 10.32 26 312822 352 110276099
Duodenal ulcer haemorrhage 57.95 10.32 91 312757 7946 110268505
Splenic haematoma 57.62 10.32 25 312823 312 110276139
Viral test positive 57.45 10.32 34 312814 844 110275607
Premature delivery 57.28 10.32 9 312839 30623 110245828
Lactic acidosis 57.24 10.32 454 312394 92357 110184094
Arteriovenous malformation 57.06 10.32 46 312802 1905 110274546
White blood cell count increased 56.61 10.32 118 312730 96724 110179727
Product monitoring error 56.13 10.32 95 312753 8832 110267619
Wound haemorrhage 55.84 10.32 68 312780 4670 110271781
General physical health deterioration 55.84 10.32 1587 311261 423708 109852743
Laryngitis 55.78 10.32 25 312823 42386 110234065
Hemiparesis 54.85 10.32 258 312590 43645 110232806
Haemorrhagic hepatic cyst 54.70 10.32 16 312832 53 110276398
Dystonia 54.60 10.32 5 312843 25800 110250651
Spontaneous haemorrhage 54.56 10.32 37 312811 1171 110275280
Bleeding time prolonged 54.37 10.32 38 312810 1264 110275187
Craniocerebral injury 54.06 10.32 75 312773 5859 110270592
Surgery 53.34 10.32 245 312603 41038 110235413
Conjunctival haemorrhage 53.33 10.32 79 312769 6554 110269897
Glomerular filtration rate abnormal 52.97 10.32 48 312800 2335 110274116
Rhinitis allergic 52.91 10.32 140 312708 17782 110258669
Hepatotoxicity 52.59 10.32 61 312787 63339 110213112
Atheroembolism 51.55 10.32 24 312824 357 110276094
Coagulation factor deficiency 51.50 10.32 23 312825 309 110276142
Gastric ulcer haemorrhage 51.41 10.32 98 312750 9996 110266455
Acute respiratory failure 51.37 10.32 377 312471 74883 110201568
Pneumonia haemophilus 51.35 10.32 50 312798 2665 110273786
Cognitive disorder 51.22 10.32 423 312425 87088 110189363
Back injury 50.76 10.32 36 312812 47363 110229088
Large intestinal haemorrhage 50.57 10.32 53 312795 3086 110273365
Hospice care 50.37 10.32 110 312738 12363 110264088
Tumour haemorrhage 50.36 10.32 68 312780 5177 110271274
Injection site pruritus 49.75 10.32 43 312805 51215 110225236
IVth nerve paralysis 49.73 10.32 28 312820 631 110275820
Purpura 49.64 10.32 167 312681 24221 110252230
Device expulsion 49.63 10.32 13 312835 30878 110245573
Wrong patient 49.57 10.32 38 312810 1461 110274990
Urogenital haemorrhage 49.53 10.32 32 312816 932 110275519
Osteonecrosis of jaw 49.45 10.32 38 312810 47979 110228472
Vena cava filter insertion 49.31 10.32 18 312830 137 110276314
Hypoxia 49.25 10.32 572 312276 128943 110147508
Extradural haematoma 49.20 10.32 54 312794 3315 110273136
Drug withdrawal syndrome 49.17 10.32 23 312825 38031 110238420
Nausea 48.98 10.32 2930 309918 1232760 109043691
Eye pruritus 48.82 10.32 203 312645 32572 110243879
Gout 48.73 10.32 219 312629 36347 110240104
Red blood cell sedimentation rate abnormal 48.66 10.32 6 312842 24503 110251948
Infarction 48.61 10.32 67 312781 5202 110271249
Drug ineffective for unapproved indication 48.56 10.32 140 312708 102698 110173753
Upper respiratory tract infection 48.33 10.32 199 312649 131129 110145322
Obstructive airways disorder 48.33 10.32 258 312590 45891 110230560
Knee arthroplasty 48.16 10.32 68 312780 64880 110211571
Haemorrhage urinary tract 48.06 10.32 50 312798 2886 110273565
Occult blood positive 47.83 10.32 80 312768 7365 110269086
Injection site swelling 47.53 10.32 63 312785 61727 110214724
Neurological symptom 47.18 10.32 123 312725 15485 110260966
Aggression 46.96 10.32 59 312789 59151 110217300
Muscle twitching 46.63 10.32 188 312660 29747 110246704
Diastolic dysfunction 46.28 10.32 106 312742 12298 110264153
Cerebral artery occlusion 46.22 10.32 41 312807 1939 110274512
Disability 46.17 10.32 14 312834 30209 110246242
Haemorrhagic diathesis 46.02 10.32 79 312769 7429 110269022
Antineutrophil cytoplasmic antibody positive 46.01 10.32 64 312784 5012 110271439
Petechiae 45.99 10.32 158 312690 23159 110253292
Insomnia 45.96 10.32 730 312118 359860 109916591
Finger deformity 45.95 10.32 18 312830 33074 110243377
Anticoagulation drug level abnormal 45.93 10.32 21 312827 299 110276152
Spinal subarachnoid haemorrhage 45.62 10.32 14 312834 57 110276394
Lip swelling 45.61 10.32 272 312576 50395 110226056
Pain in jaw 45.60 10.32 274 312574 50903 110225548
Rheumatoid nodule 45.57 10.32 3 312845 20293 110256158
Heart rate abnormal 45.47 10.32 77 312771 7161 110269290
Neoplasm malignant 45.47 10.32 217 312631 36926 110239525
Chronic left ventricular failure 45.39 10.32 34 312814 1262 110275189
Drug tolerance decreased 45.38 10.32 11 312837 27529 110248922
Haemobilia 44.60 10.32 26 312822 627 110275824
Coagulation factor V level abnormal 44.49 10.32 17 312831 149 110276302
Tongue biting 44.47 10.32 48 312800 2891 110273560
Capillaritis 44.42 10.32 44 312804 2395 110274056
Sleep apnoea syndrome 44.33 10.32 229 312619 40218 110236233
Sulphaemoglobinaemia 44.14 10.32 25 312823 570 110275881
Limb injury 44.00 10.32 217 312631 37419 110239032
Overdose 43.79 10.32 436 312412 233358 110043093
Joint dislocation 43.66 10.32 21 312827 34169 110242282
Diverticulum 43.54 10.32 119 312729 15407 110261044
Intra-abdominal haemorrhage 43.49 10.32 64 312784 5278 110271173
Neck pain 43.20 10.32 190 312658 122940 110153511
Subcutaneous haematoma 43.19 10.32 48 312800 2988 110273463
Colon cancer 43.13 10.32 123 312725 16320 110260131
Catheterisation cardiac 43.13 10.32 69 312779 6122 110270329
Angiodysplasia 43.05 10.32 35 312813 1467 110274984
Amyloidosis 43.04 10.32 49 312799 3132 110273319
Dizziness postural 43.01 10.32 114 312734 14495 110261956
Adverse reaction 42.94 10.32 15 312833 29579 110246872
Intracranial haematoma 42.76 10.32 30 312818 1004 110275447
Hydrocephalus 42.47 10.32 92 312756 10283 110266168
Adverse event 42.47 10.32 483 312365 108326 110168125
Respiratory symptom 42.36 10.32 115 312733 14830 110261621
Abortion spontaneous 42.35 10.32 22 312826 34260 110242191
Gastrointestinal arteriovenous malformation 42.26 10.32 29 312819 936 110275515
Glomerular filtration rate decreased 42.08 10.32 178 312670 28778 110247673
Normal newborn 41.94 10.32 6 312842 21890 110254561
Ecchymosis 41.94 10.32 126 312722 17212 110259239
Cardiac ventricular thrombosis 41.78 10.32 48 312800 3099 110273352
Splenic haemorrhage 41.59 10.32 27 312821 793 110275658
Rash papular 40.24 10.32 170 312678 27469 110248982
Subcapsular renal haematoma 39.89 10.32 28 312820 938 110275513
IgA nephropathy 39.79 10.32 47 312801 3126 110273325
Normocytic anaemia 39.58 10.32 68 312780 6399 110270052
Oral candidiasis 39.40 10.32 41 312807 44719 110231732
Frequent bowel movements 39.24 10.32 90 312758 71300 110205151
Mania 39.14 10.32 6 312842 20790 110255661
Catheter site pruritus 39.06 10.32 40 312808 2266 110274185
Therapy change 39.05 10.32 87 312761 9910 110266541
Catheter site erythema 39.03 10.32 65 312783 5963 110270488
Colitis ulcerative 39.01 10.32 102 312746 77261 110199190
Anxiety 38.98 10.32 714 312134 344364 109932087
Eye haemorrhage 38.94 10.32 96 312752 11678 110264773
Hyponatraemia 38.60 10.32 846 312002 216807 110059644
Hypokalaemia 38.59 10.32 728 312120 181720 110094731
Factor V Leiden mutation 38.41 10.32 18 312830 272 110276179
Immunodeficiency 38.41 10.32 32 312816 38806 110237645
Catheter management 38.29 10.32 50 312798 3685 110272766
Gastrointestinal ulcer haemorrhage 38.18 10.32 34 312814 1616 110274835
Mitral valve incompetence 38.14 10.32 191 312657 33138 110243313
Agitation 38.13 10.32 177 312671 112874 110163577
Traumatic haemothorax 38.13 10.32 25 312823 747 110275704
Renal haemorrhage 37.79 10.32 41 312807 2484 110273967
Respiratory arrest 37.59 10.32 67 312781 58232 110218219
Exercise tolerance decreased 37.41 10.32 96 312752 11971 110264480
Posterior reversible encephalopathy syndrome 37.22 10.32 25 312823 33836 110242615
Hip fracture 37.14 10.32 197 312651 34954 110241497
Akathisia 37.07 10.32 3 312845 17110 110259341
Body temperature increased 36.99 10.32 61 312787 54652 110221799
Drug use disorder 36.94 10.32 4 312844 18070 110258381
Diabetes mellitus 36.94 10.32 150 312698 99231 110177220
Condition aggravated 36.85 10.32 1701 311147 733135 109543316
Irritability 36.51 10.32 49 312799 47760 110228691
Neutrophil count decreased 36.42 10.32 197 312651 120744 110155707
Anti factor X activity increased 36.42 10.32 13 312835 92 110276359
Osteopenia 36.34 10.32 9 312839 22200 110254251
Gastrointestinal endoscopic therapy 36.33 10.32 12 312836 65 110276386
Embolism 36.26 10.32 115 312733 16174 110260277
Epstein-Barr virus infection 36.21 10.32 5 312843 18733 110257718
Cardiogenic shock 36.19 10.32 282 312566 57056 110219395
Gingival bleeding 36.17 10.32 131 312717 19708 110256743
Bone marrow failure 35.94 10.32 68 312780 57780 110218671
Obstruction 35.88 10.32 61 312787 5691 110270760
Amyloidosis senile 35.83 10.32 13 312835 97 110276354
Thrombocytopenia 35.80 10.32 1264 311584 347621 109928830
Percutaneous coronary intervention 35.67 10.32 20 312828 447 110276004
Somnolence 35.32 10.32 610 312238 296839 109979612
Ear haemorrhage 35.30 10.32 39 312809 2412 110274039
Skull fracture 35.09 10.32 36 312812 2044 110274407
Haemangioma of spleen 35.05 10.32 9 312839 15 110276436
Spinal epidural haematoma 34.96 10.32 33 312815 1692 110274759
Tachyarrhythmia 34.67 10.32 74 312774 8187 110268264
Nephropathy 34.61 10.32 100 312748 13367 110263084
Endocarditis noninfective 34.54 10.32 17 312831 288 110276163
Catheter site irritation 34.44 10.32 22 312826 628 110275823
Hyperthyroidism 34.41 10.32 169 312679 29092 110247359
Antiphospholipid syndrome 34.37 10.32 39 312809 2484 110273967
Generalised tonic-clonic seizure 34.22 10.32 64 312784 54616 110221835
Graft versus host disease 34.11 10.32 6 312842 18800 110257651
Impaired work ability 34.08 10.32 16 312832 26403 110250048
Diverticulum intestinal 34.05 10.32 91 312757 11628 110264823
Fungal infection 34.02 10.32 57 312791 50749 110225702
Device pacing issue 34.00 10.32 14 312834 152 110276299
Orthostatic hypotension 33.95 10.32 311 312537 65938 110210513
Progressive multifocal leukoencephalopathy 33.95 10.32 14 312834 24942 110251509
Blood pressure systolic abnormal 33.71 10.32 14 312834 24836 110251615
Device alarm issue 33.64 10.32 38 312810 2408 110274043
Mallory-Weiss syndrome 33.47 10.32 43 312805 3118 110273333
Intestinal haemorrhage 33.43 10.32 68 312780 7273 110269178
Gastritis haemorrhagic 33.34 10.32 43 312805 3130 110273321
Radiculopathy 33.31 10.32 7 312841 19329 110257122
Lymphocyte count decreased 33.24 10.32 70 312778 57173 110219278
Cholestasis 33.13 10.32 303 312545 64215 110212236
Transplant rejection 33.07 10.32 14 312834 24553 110251898
Atrioventricular block 32.97 10.32 114 312734 16763 110259688
Renal failure 32.97 10.32 857 311991 225717 110050734
Gastrointestinal tract mucosal pigmentation 32.95 10.32 28 312820 1249 110275202
Pulmonary haemorrhage 32.89 10.32 112 312736 16344 110260107
Gastrointestinal vascular malformation haemorrhagic 32.71 10.32 25 312823 957 110275494
Renal haematoma 32.69 10.32 25 312823 958 110275493
Abdominal pain 32.67 10.32 1155 311693 511834 109764617
Listless 32.39 10.32 51 312797 4464 110271987
Feeling hot 32.32 10.32 140 312708 90966 110185485
Brain herniation 32.26 10.32 75 312773 8788 110267663
Cerebrospinal fluid retention 32.14 10.32 12 312836 98 110276353
Nodule 31.86 10.32 179 312669 32452 110243999
Paraesthesia oral 31.77 10.32 29 312819 33642 110242809
Schizophrenia 31.77 10.32 11 312837 21815 110254636
Hypomagnesaemia 31.75 10.32 285 312563 60085 110216366
Hypercoagulation 31.75 10.32 43 312805 3283 110273168
Sinus bradycardia 31.67 10.32 166 312682 29317 110247134
Periorbital haematoma 31.61 10.32 25 312823 1007 110275444
Fear 31.57 10.32 13 312835 23180 110253271
Microcytic anaemia 31.21 10.32 60 312788 6158 110270293
Haemorrhoids 31.15 10.32 190 312658 35482 110240969
Chronic sinusitis 31.13 10.32 16 312832 25068 110251383
Cerebral artery embolism 31.10 10.32 34 312814 2078 110274373
Productive cough 31.06 10.32 475 312373 113830 110162621
Plasma cell myeloma 31.02 10.32 293 312555 62643 110213808
Brain contusion 30.83 10.32 30 312818 1598 110274853
Extrapyramidal disorder 30.81 10.32 22 312826 28845 110247606
Urethral haemorrhage 30.72 10.32 19 312829 512 110275939
Gastrointestinal polyp haemorrhage 30.67 10.32 22 312826 763 110275688
Cardiac fibrillation 30.57 10.32 25 312823 1057 110275394
Female genital tract fistula 30.56 10.32 5 312843 16514 110259937
Haemorrhagic ascites 30.53 10.32 16 312832 311 110276140
Pallor 30.43 10.32 268 312580 56199 110220252
Epilepsy 30.30 10.32 163 312685 100046 110176405
Medication error 30.24 10.32 442 312406 104924 110171527
Polypectomy 30.19 10.32 29 312819 1520 110274931
Skin pressure mark 29.99 10.32 11 312837 85 110276366
Acquired haemophilia 29.78 10.32 37 312811 2594 110273857
Vaginal haemorrhage 29.62 10.32 145 312703 24929 110251522
Tooth disorder 29.56 10.32 163 312685 29346 110247105
Electrocardiogram abnormal 29.54 10.32 118 312730 18591 110257860
Pancreatitis 29.48 10.32 150 312698 93383 110183068
Influenza like illness 29.48 10.32 139 312709 88273 110188178
Prosthetic cardiac valve thrombosis 29.44 10.32 11 312837 90 110276361
Aplastic anaemia 29.44 10.32 16 312832 24292 110252159
Crying 29.43 10.32 18 312830 25610 110250841
Therapy partial responder 29.31 10.32 37 312811 37024 110239427
Pathogen resistance 29.23 10.32 7 312841 17665 110258786
Clotting factor transfusion 29.22 10.32 6 312842 0 110276451
Pulmonary oedema 29.18 10.32 423 312425 100236 110176215
Right ventricular failure 29.18 10.32 148 312700 25806 110250645
Vascular purpura 29.02 10.32 44 312804 3727 110272724
Respiratory disorder 28.94 10.32 104 312744 71278 110205173
Cytomegalovirus infection reactivation 28.91 10.32 8 312840 18325 110258126
Suicidal ideation 28.85 10.32 152 312696 93785 110182666
COVID-19 pneumonia 28.83 10.32 192 312656 36951 110239500
Aortic intramural haematoma 28.69 10.32 13 312835 181 110276270
Pulmonary function test abnormal 28.55 10.32 51 312797 4949 110271502
Hallucination 28.52 10.32 424 312424 101008 110175443
Orthopnoea 28.48 10.32 82 312766 10939 110265512
Bronchial wall thickening 28.42 10.32 40 312808 3167 110273284
Caesarean section 28.39 10.32 3 312845 13814 110262637
Cerebral ischaemia 28.37 10.32 87 312761 12017 110264434
Post transplant lymphoproliferative disorder 28.28 10.32 5 312843 15608 110260843
Angiodermatitis 28.25 10.32 13 312835 188 110276263
Migraine 28.16 10.32 330 312518 171322 110105129
Anti-neutrophil cytoplasmic antibody positive vasculitis 28.09 10.32 53 312795 5364 110271087
Hyperphosphataemia 28.08 10.32 6 312842 16375 110260076
Therapy cessation 27.97 10.32 220 312628 44637 110231814
Vaginal discharge 27.90 10.32 8 312840 17900 110258551
Disease progression 27.84 10.32 504 312344 243530 110032921
Gastrointestinal tube insertion 27.81 10.32 32 312816 2069 110274382
Hepatic function abnormal 27.70 10.32 144 312704 89151 110187300
Infusion site haemorrhage 27.68 10.32 48 312800 4550 110271901
Catheter site discharge 27.66 10.32 38 312810 2941 110273510
Fracture 27.62 10.32 141 312707 24647 110251804
Intracardiac thrombus 27.61 10.32 46 312802 4222 110272229
Infusion site reaction 27.36 10.32 8 312840 17674 110258777
Sinobronchitis 27.26 10.32 17 312831 465 110275986
Bone density decreased 27.24 10.32 6 312842 16036 110260415
Sedation complication 27.24 10.32 11 312837 19844 110256607
Dry skin 27.22 10.32 442 312406 107211 110169240
Benign prostatic hyperplasia 27.20 10.32 113 312735 18121 110258330
Skin laceration 27.12 10.32 176 312672 33577 110242874
Embolic cerebral infarction 27.12 10.32 27 312821 1479 110274972
Prohormone brain natriuretic peptide increased 27.11 10.32 16 312832 395 110276056
Subchondral insufficiency fracture 27.06 10.32 9 312839 50 110276401
Defaecation disorder 27.03 10.32 21 312827 824 110275627
Cerebellar infarction 26.91 10.32 45 312803 4142 110272309
Walking aid user 26.91 10.32 19 312829 25056 110251395
Lymphadenopathy 26.55 10.32 92 312756 63743 110212708
Blood parathyroid hormone decreased 26.49 10.32 3 312845 13086 110263365
Femoral neck fracture 26.42 10.32 87 312761 12480 110263971
Disturbance in attention 26.39 10.32 280 312568 61715 110214736
Gastric antral vascular ectasia 26.39 10.32 24 312824 1173 110275278
Platypnoea 26.18 10.32 8 312840 32 110276419
Anti factor Xa activity decreased 26.12 10.32 7 312841 15 110276436
Panniculitis 26.12 10.32 6 312842 15576 110260875
Ocular retrobulbar haemorrhage 26.11 10.32 12 312836 173 110276278
Blood calcium decreased 26.11 10.32 38 312810 35807 110240644
Taste disorder 26.02 10.32 96 312752 65291 110211160
Tachycardia 26.00 10.32 832 312016 225813 110050638
Neutrophil count increased 25.97 10.32 36 312812 34616 110241835
Benign gastrointestinal neoplasm 25.96 10.32 11 312837 129 110276322
Thirst decreased 25.95 10.32 15 312833 356 110276095
Heart rate irregular 25.90 10.32 176 312672 34098 110242353
Tremor 25.88 10.32 409 312439 201823 110074628
Hepatitis 25.86 10.32 149 312699 89905 110186546
Arterial haemorrhage 25.83 10.32 42 312806 3777 110272674
Temperature regulation disorder 25.81 10.32 3 312845 12823 110263628
Mucosal haemorrhage 25.78 10.32 37 312811 2983 110273468
Multiple sclerosis 25.62 10.32 21 312827 25677 110250774
Hypertriglyceridaemia 25.57 10.32 7 312841 16147 110260304
Oesophageal achalasia 25.56 10.32 22 312826 999 110275452
Granulocytopenia 25.52 10.32 3 312845 12712 110263739
Pituitary apoplexy 25.45 10.32 14 312834 301 110276150
Aneurysm ruptured 25.41 10.32 23 312825 1117 110275334
Cardioactive drug level increased 25.32 10.32 42 312806 3840 110272611
Cerebellar haematoma 25.31 10.32 18 312830 616 110275835
Transcatheter aortic valve implantation 25.18 10.32 9 312839 64 110276387
Laryngeal haemorrhage 25.18 10.32 9 312839 64 110276387
Tendonitis 25.17 10.32 22 312826 26061 110250390
Intentional self-injury 25.05 10.32 42 312806 37387 110239064
Neuroleptic malignant syndrome 24.92 10.32 36 312812 34023 110242428
Toxic epidermal necrolysis 24.80 10.32 80 312768 56647 110219804
Traumatic intracranial haematoma 24.75 10.32 8 312840 40 110276411
Aortic valve disease 24.70 10.32 31 312817 2196 110274255
Bronchial secretion retention 24.63 10.32 48 312800 4976 110271475
Injection site urticaria 24.51 10.32 9 312839 17206 110259245
Haemophagocytic lymphohistiocytosis 24.45 10.32 32 312816 31527 110244924
Platelet distribution width increased 24.42 10.32 11 312837 151 110276300
Hepatic haemangioma rupture 24.35 10.32 5 312843 0 110276451
Seronegative arthritis 24.35 10.32 4 312844 13173 110263278
Abnormal loss of weight 24.30 10.32 74 312774 10183 110266268
Calciphylaxis 24.29 10.32 43 312805 4144 110272307
Blood pressure decreased 24.25 10.32 459 312389 114632 110161819
Aspergillus infection 24.24 10.32 22 312826 25594 110250857
Neovascular age-related macular degeneration 24.20 10.32 17 312831 570 110275881
Product complaint 24.19 10.32 5 312843 13967 110262484
BK virus infection 24.17 10.32 4 312844 13102 110263349
Infective pulmonary exacerbation of cystic fibrosis 24.14 10.32 6 312842 14765 110261686
Haemoglobin abnormal 24.09 10.32 68 312780 8970 110267481
Ovarian cyst 24.09 10.32 5 312843 13925 110262526
Proteinuria 24.03 10.32 48 312800 39970 110236481
Treatment delayed 24.03 10.32 16 312832 491 110275960
Carotid artery stenosis 24.01 10.32 69 312779 9194 110267257
Throat tightness 23.91 10.32 36 312812 33453 110242998
Peripheral artery stenosis 23.87 10.32 24 312824 1330 110275121
Hypoacusis 23.85 10.32 176 312672 35015 110241436
Anhedonia 23.84 10.32 7 312841 15421 110261030
Inability to afford medication 23.82 10.32 42 312806 4034 110272417
Anaphylactic shock 23.73 10.32 71 312777 51475 110224976
Xyphoid retraction 23.73 10.32 11 312837 162 110276289
Subdural hygroma 23.72 10.32 17 312831 589 110275862
Haemorrhagic cerebral infarction 23.65 10.32 25 312823 1470 110274981
Anticoagulation drug level above therapeutic 23.64 10.32 45 312803 4585 110271866
Labelled drug-drug interaction issue 23.64 10.32 42 312806 4059 110272392
Vascular device infection 23.60 10.32 101 312747 16411 110260040
Anticoagulation drug level decreased 23.57 10.32 13 312835 281 110276170
Craniotomy 23.52 10.32 17 312831 597 110275854
Cardiorenal syndrome 23.38 10.32 28 312820 1890 110274561
Photophobia 23.37 10.32 23 312825 25748 110250703
Oedema 23.21 10.32 436 312412 209540 110066911
Aortic aneurysm rupture 23.20 10.32 24 312824 1376 110275075
Prostatic adenoma 23.18 10.32 10 312838 123 110276328
Pharyngeal haemorrhage 23.10 10.32 24 312824 1383 110275068
Osteoporosis 23.03 10.32 148 312700 87004 110189447
Putamen haemorrhage 22.98 10.32 16 312832 529 110275922
Herpes zoster 22.92 10.32 196 312652 108183 110168268
Mental disorder 22.89 10.32 47 312801 38744 110237707
White blood cell count decreased 22.75 10.32 485 312363 228905 110047546
Varicophlebitis 22.74 10.32 8 312840 54 110276397
Blood creatinine abnormal 22.71 10.32 51 312797 5841 110270610
Blood creatine phosphokinase increased 22.58 10.32 118 312730 72959 110203492
Neurotoxicity 22.56 10.32 54 312794 42153 110234298
Ankylosing spondylitis 22.50 10.32 8 312840 15604 110260847
Gastric ischaemia 22.37 10.32 8 312840 57 110276394
Product administration error 22.37 10.32 181 312667 37036 110239415
Duodenal vascular ectasia 22.35 10.32 6 312842 13 110276438
Anastomotic infection 22.28 10.32 10 312838 136 110276315
Respiratory depression 22.27 10.32 35 312813 31966 110244485
Embolism venous 22.25 10.32 46 312802 4977 110271474
Bladder irrigation 22.25 10.32 8 312840 58 110276393
Polyarthritis 22.22 10.32 13 312835 18950 110257501
Psychotic disorder 22.15 10.32 72 312776 50865 110225586
Low cardiac output syndrome 22.11 10.32 21 312827 1085 110275366
Hemiparaesthesia 22.09 10.32 14 312834 394 110276057
Central nervous system lupus 22.07 10.32 23 312825 1330 110275121
Peripheral arterial occlusive disease 22.03 10.32 67 312781 9213 110267238
Catatonia 21.87 10.32 3 312845 11297 110265154
Leukopenia 21.80 10.32 293 312555 148498 110127953
Subclavian vein thrombosis 21.73 10.32 33 312815 2799 110273652
Echocardiogram abnormal 21.72 10.32 32 312816 2642 110273809
Peripheral artery thrombosis 21.65 10.32 40 312808 3984 110272467
Gastrointestinal polyp 21.65 10.32 11 312837 200 110276251
Helicobacter test false negative 21.57 10.32 8 312840 64 110276387
Acute myocardial infarction 21.56 10.32 345 312503 83432 110193019
Osteonecrosis 21.55 10.32 39 312809 33702 110242749
Infusion site pain 21.49 10.32 102 312746 17317 110259134
Candida infection 21.48 10.32 67 312781 47942 110228509
Rectal ulcer haemorrhage 21.43 10.32 13 312835 338 110276113
Blood pressure systolic increased 21.39 10.32 142 312706 82849 110193602
Catheter site rash 21.28 10.32 20 312828 1020 110275431
Rectosigmoid cancer 21.26 10.32 13 312835 343 110276108
Drug-induced liver injury 21.20 10.32 227 312621 119840 110156611
Peripheral artery occlusion 21.10 10.32 33 312815 2872 110273579
Hypertension 21.08 10.32 1204 311644 508880 109767571
Device occlusion 21.03 10.32 92 312756 15093 110261358
Femoral artery aneurysm 20.98 10.32 11 312837 214 110276237
Product administration interrupted 20.96 10.32 75 312773 11217 110265234
Troponin T increased 20.94 10.32 41 312807 4265 110272186
Orbital compartment syndrome 20.91 10.32 9 312839 110 110276341
Appendicitis 20.91 10.32 30 312818 28434 110248017
Metallosis of globe 20.90 10.32 5 312843 5 110276446
Cardiac valve disease 20.86 10.32 52 312796 6369 110270082
Gastritis erosive 20.84 10.32 78 312770 11922 110264529
Abnormal behaviour 20.82 10.32 50 312798 38989 110237462
Embolism arterial 20.81 10.32 26 312822 1833 110274618
Ventricular drainage 20.72 10.32 6 312842 19 110276432
Cushingoid 20.68 10.32 4 312844 11708 110264743
Eye haematoma 20.64 10.32 12 312836 288 110276163
Adjustment disorder 20.58 10.32 3 312845 10792 110265659
Oxygen consumption increased 20.57 10.32 48 312800 5637 110270814
Hepatic haemorrhage 20.56 10.32 22 312826 1312 110275139
Subdural haematoma evacuation 20.56 10.32 8 312840 74 110276377
Injection site warmth 20.30 10.32 12 312836 17393 110259058
Mediastinal haematoma 20.27 10.32 11 312837 230 110276221
Myocardial infarction 20.20 10.32 698 312150 191385 110085066
Bronchospasm 20.18 10.32 34 312814 30205 110246246
Infusion site erythema 20.16 10.32 77 312771 11882 110264569
Off label use 20.14 10.32 4661 308187 1495524 108780927
Small intestinal haemorrhage 20.11 10.32 42 312806 4576 110271875
Pericardial drainage 20.08 10.32 14 312834 464 110275987
Headache 20.01 10.32 2188 310660 880189 109396262
Haemorrhagic transformation stroke 20.00 10.32 33 312815 3004 110273447
Bladder neoplasm 20.00 10.32 26 312822 1908 110274543
Drug dose omission by device 19.98 10.32 8 312840 14508 110261943
Vascular device occlusion 19.94 10.32 16 312832 658 110275793
Injection site bruising 19.92 10.32 76 312772 51187 110225264
Conjunctivitis 19.89 10.32 41 312807 33751 110242700
Pruritus 19.68 10.32 1398 311450 580162 109696289
Confusional state 19.59 10.32 1105 311743 467575 109808876
Electrolyte imbalance 19.57 10.32 175 312673 36853 110239598
Affective disorder 19.51 10.32 4 312844 11237 110265214
Therapeutic product effect incomplete 19.44 10.32 483 312365 223322 110053129
Malaise 19.29 10.32 1637 311211 670182 109606269
Occult blood 19.27 10.32 25 312823 1831 110274620
Therapeutic aspiration 19.23 10.32 5 312843 9 110276442
Full blood count decreased 19.23 10.32 156 312692 31943 110244508
Chills 19.17 10.32 402 312446 190178 110086273
Respiratory tract haemorrhage 19.17 10.32 26 312822 1988 110274463
Hepatic cytolysis 19.11 10.32 239 312609 54814 110221637
Urinary retention 19.09 10.32 290 312558 69393 110207058
Hypomania 19.09 10.32 3 312845 10207 110266244
Deformity 18.96 10.32 3 312845 10157 110266294
Puncture site haematoma 18.95 10.32 11 312837 263 110276188
Vitreous haemorrhage 18.95 10.32 41 312807 4579 110271872
Gait disturbance 18.94 10.32 621 312227 277587 109998864
Left ventricular failure 18.93 10.32 73 312775 11316 110265135
Asthenia 18.92 10.32 2226 310622 686773 109589678
Thyrotoxic crisis 18.91 10.32 26 312822 2014 110274437
Kyphosis 18.84 10.32 33 312815 3154 110273297
Eosinophilic pleural effusion 18.82 10.32 14 312834 514 110275937
Haemodynamic instability 18.79 10.32 120 312728 22768 110253683
Liver function test increased 18.79 10.32 160 312688 88388 110188063
Thrombophlebitis 18.76 10.32 56 312792 7623 110268828
Creatinine renal clearance abnormal 18.75 10.32 16 312832 718 110275733
Tongue injury 18.69 10.32 15 312833 617 110275834
Calculus bladder 18.69 10.32 24 312824 1740 110274711
Substance abuse 18.63 10.32 6 312842 12457 110263994
Loss of personal independence in daily activities 18.60 10.32 556 312292 149464 110126987
Venous pressure jugular increased 18.59 10.32 21 312827 1331 110275120
Helicobacter test positive 18.58 10.32 21 312827 1332 110275119
Wrong drug 18.45 10.32 13 312835 438 110276013
Tuberculosis 18.38 10.32 14 312834 17760 110258691
Cytomegalovirus viraemia 18.36 10.32 14 312834 17750 110258701
Nightmare 18.27 10.32 53 312795 38810 110237641
Brain compression 18.25 10.32 16 312832 745 110275706
Product prescribing issue 18.16 10.32 78 312770 12694 110263757
Coordination abnormal 18.13 10.32 27 312821 25201 110251250
Suicide attempt 18.04 10.32 196 312652 103198 110173253
Butterfly rash 18.03 10.32 26 312822 2105 110274346
Haemorrhagic infarction 18.00 10.32 17 312831 872 110275579
Mucormycosis 18.00 10.32 4 312844 10624 110265827
Contraindicated product prescribed 17.99 10.32 27 312821 2266 110274185
Post procedural stroke 17.94 10.32 8 312840 107 110276344
Pustular psoriasis 17.92 10.32 8 312840 13597 110262854
Tachycardia induced cardiomyopathy 17.89 10.32 10 312838 222 110276229
Uveitis 17.88 10.32 21 312827 21689 110254762
Meningorrhagia 17.83 10.32 12 312836 375 110276076
Acne 17.82 10.32 43 312805 33477 110242974
Thrombotic stroke 17.77 10.32 16 312832 772 110275679
Wrong dose 17.74 10.32 29 312819 2620 110273831
Spontaneous hyphaema 17.72 10.32 5 312843 14 110276437
Blood lactate dehydrogenase increased 17.70 10.32 65 312783 44269 110232182
Circumstance or information capable of leading to medication error 17.66 10.32 43 312805 5190 110271261
Inguinal hernia 17.62 10.32 55 312793 7670 110268781
Inappropriate schedule of product administration 17.54 10.32 440 312408 203197 110073254
Neuralgia 17.49 10.32 74 312774 48404 110228047
Left atrial enlargement 17.48 10.32 23 312825 1708 110274743
Breath sounds abnormal 17.48 10.32 28 312820 25376 110251075
Ruptured cerebral aneurysm 17.47 10.32 15 312833 679 110275772
Sensory loss 17.41 10.32 21 312827 21436 110255015
Paratonia 17.38 10.32 6 312842 38 110276413
Nephropathy toxic 17.34 10.32 32 312816 27446 110249005
Optic neuritis 17.33 10.32 5 312843 11142 110265309
Product commingling 17.31 10.32 8 312840 117 110276334
Haemorrhagic cyst 17.31 10.32 12 312836 394 110276057
Portal hypertensive gastropathy 17.21 10.32 24 312824 1884 110274567
Anger 17.20 10.32 17 312831 18990 110257461
Oxygen saturation decreased 17.15 10.32 573 312275 156409 110120042
Anaphylactic reaction 17.14 10.32 224 312624 114076 110162375
Feeling abnormal 17.12 10.32 649 312199 180062 110096389
Anal haemorrhage 17.04 10.32 41 312807 4911 110271540
Paranoia 17.01 10.32 23 312825 22351 110254100
Splenic infarction 17.01 10.32 38 312810 4336 110272115
Tinnitus 16.99 10.32 253 312595 60287 110216164
Coma uraemic 16.87 10.32 6 312842 42 110276409
Product dispensing error 16.85 10.32 91 312757 16254 110260197
Herpes simplex 16.84 10.32 12 312836 15752 110260699
Blood triglycerides increased 16.81 10.32 26 312822 23900 110252551
Cellulitis gangrenous 16.79 10.32 12 312836 414 110276037
Arterial thrombosis 16.78 10.32 31 312817 3088 110273363
Cerebral thrombosis 16.66 10.32 27 312821 2421 110274030
Hyperkaliuria 16.64 10.32 9 312839 187 110276264
Sinus tachycardia 16.63 10.32 67 312781 44426 110232025
Amenorrhoea 16.62 10.32 3 312845 9228 110267223
Poisoning 16.56 10.32 36 312812 29069 110247382
Mast cell activation syndrome 16.52 10.32 21 312827 1507 110274944
Listeraemia 16.45 10.32 7 312841 83 110276368
Joint effusion 16.40 10.32 21 312827 20884 110255567
Sticky platelet syndrome 16.36 10.32 5 312843 20 110276431
Vertebrobasilar stroke 16.36 10.32 5 312843 20 110276431
Rehabilitation therapy 16.32 10.32 25 312823 2136 110274315
Prostatic haemorrhage 16.30 10.32 9 312839 195 110276256
Gastrostomy 16.28 10.32 21 312827 1529 110274922
Blood creatinine increased 16.20 10.32 652 312196 182237 110094214
Dry eye 16.18 10.32 92 312756 55701 110220750
Meningitis aseptic 16.15 10.32 4 312844 9866 110266585
Renal infarct 16.12 10.32 32 312816 3363 110273088
Cerebral amyloid angiopathy 16.05 10.32 13 312835 542 110275909
Stent placement 16.04 10.32 51 312797 7183 110269268
Peripheral embolism 16.02 10.32 24 312824 2011 110274440
Hyperkinetic heart syndrome 16.02 10.32 8 312840 140 110276311
Cardiac flutter 16.02 10.32 44 312804 5713 110270738
Tricuspid valve repair 15.98 10.32 5 312843 22 110276429
Splenomegaly 15.93 10.32 28 312820 24470 110251981
Ilium fracture 15.86 10.32 10 312838 279 110276172
Hepatic cirrhosis 15.82 10.32 119 312729 67507 110208944
Polyp 15.80 10.32 63 312785 9917 110266534
Haematotoxicity 15.70 10.32 22 312826 21060 110255391
Throat irritation 15.70 10.32 88 312760 53464 110222987
Graft haemorrhage 15.68 10.32 7 312841 94 110276357
Adrenal haematoma 15.67 10.32 8 312840 147 110276304
Brain natriuretic peptide increased 15.59 10.32 68 312780 11141 110265310
Impaired quality of life 15.57 10.32 39 312809 29978 110246473
Hepatic steatosis 15.56 10.32 78 312770 48753 110227698
Angiocardiogram 15.55 10.32 10 312838 289 110276162
Gingival pain 15.52 10.32 13 312835 15723 110260728
Heavy menstrual bleeding 15.47 10.32 89 312759 16276 110260175
Tenderness 15.47 10.32 38 312810 29399 110247052
Degenerative aortic valve disease 15.44 10.32 9 312839 217 110276234
Prerenal failure 15.43 10.32 37 312811 4422 110272029
Sudden death 15.40 10.32 120 312728 24275 110252176
Rhinitis 15.37 10.32 25 312823 22520 110253931
Immunosuppressant drug level increased 15.28 10.32 7 312841 11717 110264734
Gastroduodenal haemorrhage 15.22 10.32 10 312838 300 110276151
Urosepsis 15.21 10.32 143 312705 30532 110245919
Renal phospholipidosis 15.20 10.32 11 312837 387 110276064
Medical observation 15.19 10.32 9 312839 224 110276227
Retinal artery embolism 15.15 10.32 8 312840 158 110276293
Bleeding varicose vein 15.14 10.32 14 312834 699 110275752
Infective exacerbation of chronic obstructive airways disease 15.06 10.32 30 312818 3160 110273291
Macroangiopathy 15.06 10.32 8 312840 160 110276291
Pulmonary artery occlusion 15.01 10.32 6 312842 60 110276391
Subarachnoid haematoma 14.98 10.32 10 312838 308 110276143
Palliative care 14.96 10.32 21 312827 1659 110274792
Fluid replacement 14.91 10.32 16 312832 957 110275494
Mood swings 14.90 10.32 26 312822 22786 110253665
Pharyngeal haematoma 14.89 10.32 8 312840 164 110276287
Prostatic disorder 14.86 10.32 26 312822 2483 110273968
Anaemia macrocytic 14.85 10.32 50 312798 7253 110269198
Blood disorder 14.80 10.32 61 312787 9749 110266702
Discoloured vomit 14.77 10.32 23 312825 1994 110274457
Peripheral artery aneurysm 14.76 10.32 12 312836 503 110275948
Hallucination, auditory 14.73 10.32 33 312815 26364 110250087
Pelvic fracture 14.73 10.32 79 312769 14075 110262376
Steroid dependence 14.73 10.32 3 312845 8466 110267985
Gastric cancer 14.72 10.32 66 312782 10942 110265509
Blood iron decreased 14.72 10.32 99 312749 19115 110257336
Panic attack 14.71 10.32 38 312810 28902 110247549
Mydriasis 14.70 10.32 25 312823 22132 110254319
Renal oncocytoma 14.67 10.32 9 312839 239 110276212
Acute graft versus host disease in skin 14.65 10.32 6 312842 10734 110265717
Left atrial appendage closure implant 14.61 10.32 3 312845 0 110276451
Anal ulcer haemorrhage 14.61 10.32 3 312845 0 110276451
Cryotherapy 14.61 10.32 3 312845 0 110276451
Atrial appendage closure 14.58 10.32 6 312842 65 110276386
Faecal vomiting 14.58 10.32 20 312828 1546 110274905
Spinal subdural haematoma 14.57 10.32 9 312839 242 110276209
Pulmonary fibrosis 14.56 10.32 202 312646 101840 110174611
Cholestatic liver injury 14.56 10.32 50 312798 7326 110269125
Peripheral ischaemia 14.56 10.32 66 312782 10992 110265459
Intracranial mass 14.47 10.32 25 312823 2363 110274088
Hepatic necrosis 14.44 10.32 5 312843 9917 110266534
Spinal fusion surgery 14.43 10.32 4 312844 9152 110267299
Page kidney 14.42 10.32 6 312842 67 110276384
Temperature intolerance 14.41 10.32 11 312837 13939 110262512
Stoma site haemorrhage 14.39 10.32 25 312823 2373 110274078
Presyncope 14.39 10.32 206 312642 48681 110227770
Prothrombin time ratio increased 14.38 10.32 10 312838 330 110276121
Chest wall haematoma 14.36 10.32 12 312836 523 110275928
Clostridium test positive 14.33 10.32 65 312783 10828 110265623
Visual acuity reduced 14.32 10.32 45 312803 32128 110244323
Intracranial haemangioma 14.31 10.32 5 312843 33 110276418
Prescription drug used without a prescription 14.31 10.32 41 312807 5455 110270996
Skin irritation 14.30 10.32 87 312761 16232 110260219
Tricuspid valve incompetence 14.29 10.32 116 312732 23757 110252694
Ischaemic cerebral infarction 14.27 10.32 28 312820 2917 110273534
Duplicate therapy error 14.24 10.32 11 312837 428 110276023
Accidental exposure to product 14.22 10.32 83 312765 49925 110226526
Sarcoidosis 14.21 10.32 9 312839 12570 110263881
Post procedural pulmonary embolism 14.21 10.32 9 312839 253 110276198
Hepatitis C 14.20 10.32 9 312839 12564 110263887
Emergency care 14.20 10.32 19 312829 1434 110275017
Salivary hypersecretion 14.19 10.32 17 312831 17404 110259047
Incision site haematoma 14.18 10.32 8 312840 181 110276270
Thrombophlebitis migrans 14.17 10.32 14 312834 760 110275691
Parosmia 14.13 10.32 10 312838 13170 110263281
Polyserositis 14.11 10.32 16 312832 1018 110275433
Peptic ulcer haemorrhage 14.09 10.32 17 312831 1156 110275295
Blood bilirubin increased 14.08 10.32 142 312706 75830 110200621
Muscle abscess 14.04 10.32 19 312829 1450 110275001
Oropharyngeal pain 14.00 10.32 284 312564 134992 110141459
Idiopathic interstitial pneumonia 14.00 10.32 14 312834 771 110275680
Blood pressure systolic decreased 13.97 10.32 75 312773 13366 110263085
Central nervous system lesion 13.97 10.32 14 312834 15539 110260912
Heparin resistance 13.93 10.32 9 312839 262 110276189
Catheter site pain 13.89 10.32 45 312803 6401 110270050
Ventricular arrhythmia 13.88 10.32 61 312787 10026 110266425
Product packaging quantity issue 13.86 10.32 21 312827 1778 110274673
Bacterial infection 13.85 10.32 75 312773 45961 110230490
Bronchopulmonary aspergillosis 13.84 10.32 41 312807 29822 110246629
Hypertransaminasaemia 13.80 10.32 30 312818 24225 110252226
Gamma-glutamyltransferase abnormal 13.78 10.32 15 312833 912 110275539
Chest X-ray abnormal 13.78 10.32 54 312794 8433 110268018
Lupus pneumonitis 13.74 10.32 7 312841 128 110276323
Peripheral artery aneurysm rupture 13.73 10.32 4 312844 13 110276438
Breast haematoma 13.72 10.32 8 312840 193 110276258
Food allergy 13.71 10.32 22 312826 19926 110256525
General symptom 13.69 10.32 4 312844 8842 110267609
Aortic stenosis 13.66 10.32 73 312775 12986 110263465
Euphoric mood 13.65 10.32 4 312844 8823 110267628
Procedural pain 13.64 10.32 53 312795 35512 110240939
Prostatic operation 13.59 10.32 10 312838 361 110276090
Injection site mass 13.55 10.32 31 312817 24582 110251869
Miosis 13.52 10.32 26 312822 21957 110254494
Acquired mixed hyperlipidaemia 13.51 10.32 4 312844 14 110276437
Acute vestibular syndrome 13.48 10.32 5 312843 40 110276411
Anaemia vitamin B12 deficiency 13.48 10.32 17 312831 1210 110275241
Odynophagia 13.48 10.32 12 312836 14089 110262362
Cholecystitis chronic 13.47 10.32 5 312843 9495 110266956
Thromboembolectomy 13.45 10.32 7 312841 134 110276317
Hepatomegaly 13.45 10.32 25 312823 21389 110255062
Myoclonus 13.43 10.32 48 312800 32950 110243501
Subcapsular splenic haematoma 13.41 10.32 6 312842 81 110276370
Circulatory collapse 13.40 10.32 183 312665 42810 110233641
Device related thrombosis 13.38 10.32 30 312818 3432 110273019
Skin hyperpigmentation 13.34 10.32 4 312844 8692 110267759
Obstructive pancreatitis 13.33 10.32 17 312831 1224 110275227
Splinter haemorrhages 13.32 10.32 7 312841 137 110276314
Aplasia 13.26 10.32 3 312845 7870 110268581
Therapeutic drug monitoring analysis incorrectly performed 13.26 10.32 13 312835 699 110275752
Congestive cardiomyopathy 13.23 10.32 77 312771 14142 110262309
Scar 13.20 10.32 17 312831 16864 110259587
Rectal prolapse 13.20 10.32 25 312823 2538 110273913
Pulmonary renal syndrome 13.19 10.32 14 312834 827 110275624
Microembolism 13.17 10.32 5 312843 43 110276408
Pulmonary haematoma 13.14 10.32 7 312841 141 110276310
Chronic obstructive pulmonary disease 13.11 10.32 403 312445 108755 110167696
Catheter placement 13.09 10.32 29 312819 3291 110273160
Vascular cauterisation 13.09 10.32 6 312842 86 110276365
Bundle branch block right 13.06 10.32 69 312779 12222 110264229
Chronic gastrointestinal bleeding 13.05 10.32 11 312837 485 110275966
Blood urea abnormal 13.04 10.32 21 312827 1873 110274578
Vision blurred 13.02 10.32 272 312576 128750 110147701
Gastroenteritis viral 12.99 10.32 45 312803 31181 110245270
Obstructive shock 12.96 10.32 7 312841 145 110276306
Cardiac pacemaker replacement 12.96 10.32 11 312837 490 110275961
Antinuclear antibody negative 12.92 10.32 7 312841 146 110276305
Blood pressure abnormal 12.91 10.32 108 312740 22316 110254135
Haemorrhage subepidermal 12.90 10.32 4 312844 17 110276434
Blood immunoglobulin M abnormal 12.87 10.32 7 312841 147 110276304
Pulse abnormal 12.85 10.32 33 312815 4116 110272335
Medical device implantation 12.85 10.32 12 312836 607 110275844
Middle insomnia 12.82 10.32 24 312824 20478 110255973
Endocarditis 12.82 10.32 73 312775 13298 110263153
Prostatectomy 12.82 10.32 8 312840 219 110276232
Hypersensitivity vasculitis 12.81 10.32 46 312802 6891 110269560
Amylase increased 12.77 10.32 10 312838 12509 110263942
Pharyngitis 12.72 10.32 33 312815 25065 110251386
Methaemoglobinaemia 12.71 10.32 5 312843 9163 110267288
Sneezing 12.70 10.32 47 312801 31937 110244514
Enthesopathy 12.69 10.32 10 312838 12468 110263983
Breast cancer female 12.67 10.32 10 312838 12458 110263993
Acute myeloid leukaemia 12.65 10.32 60 312788 38050 110238401
Epidural haemorrhage 12.64 10.32 10 312838 403 110276048
Renal tubular necrosis 12.62 10.32 44 312804 30431 110246020
Right ventricular enlargement 12.60 10.32 15 312833 1006 110275445
Facial paresis 12.56 10.32 42 312806 6071 110270380
Prohormone brain natriuretic peptide abnormal 12.54 10.32 3 312845 3 110276448
Puncture site abscess 12.54 10.32 3 312845 3 110276448
Mood altered 12.53 10.32 26 312822 21349 110255102
Haemorrhoids thrombosed 12.53 10.32 9 312839 313 110276138
Cerebellar stroke 12.51 10.32 14 312834 878 110275573
Agonal respiration 12.48 10.32 9 312839 315 110276136
Blood immunoglobulin E increased 12.47 10.32 48 312800 7434 110269017
Ileus paralytic 12.46 10.32 9 312839 11728 110264723
Pneumonia fungal 12.45 10.32 14 312834 14740 110261711
Mitral valve thickening 12.42 10.32 13 312835 756 110275695
Feeling jittery 12.39 10.32 14 312834 14708 110261743
Factor Xa activity increased 12.37 10.32 4 312844 20 110276431
Oesophagitis 12.37 10.32 130 312718 28585 110247866
Adenocarcinoma of colon 12.34 10.32 42 312806 6126 110270325
Eyelid oedema 12.32 10.32 15 312833 15247 110261204
Infusion site swelling 12.30 10.32 58 312790 9819 110266632
Pelvic haematoma 12.27 10.32 15 312833 1034 110275417
Hepatic encephalopathy 12.24 10.32 40 312808 28216 110248235
Thyroid haemorrhage 12.22 10.32 6 312842 101 110276350
Complications of transplanted kidney 12.21 10.32 3 312845 7439 110269012
Transfusion-related circulatory overload 12.15 10.32 14 312834 907 110275544
Cutaneous lupus erythematosus 12.13 10.32 29 312819 3459 110272992
Fear of injection 12.12 10.32 5 312843 8906 110267545
Pneumocystis jirovecii pneumonia 12.11 10.32 71 312777 42664 110233787
Biliary sepsis 12.10 10.32 20 312828 1823 110274628
Myeloblast count increased 12.09 10.32 5 312843 55 110276396
Aplasia pure red cell 12.05 10.32 6 312842 9572 110266879
Wound haematoma 12.04 10.32 7 312841 168 110276283
Rash erythematous 12.04 10.32 161 312687 81671 110194780
Forced expiratory volume decreased 12.03 10.32 71 312777 13105 110263346
Erythromelalgia 12.02 10.32 10 312838 433 110276018
Gingival oedema 12.02 10.32 6 312842 105 110276346
Klebsiella infection 12.01 10.32 24 312824 19985 110256466
Blood sodium abnormal 12.01 10.32 17 312831 1353 110275098
Peptic ulcer 11.99 10.32 48 312800 7571 110268880
Haemostasis 11.97 10.32 11 312837 545 110275906
Disease recurrence 11.94 10.32 112 312736 60672 110215779
Metastases to lung 11.94 10.32 30 312818 23033 110253418
Paradoxical embolism 11.93 10.32 5 312843 57 110276394
Amaurosis fugax 11.92 10.32 23 312825 2367 110274084
Dyspnoea at rest 11.89 10.32 51 312797 8295 110268156
Withdrawal syndrome 11.89 10.32 47 312801 31333 110245118
Large intestinal polypectomy 11.89 10.32 10 312838 440 110276011
Intestinal perforation 11.84 10.32 26 312822 20918 110255533
Cardiac ventricular disorder 11.83 10.32 9 312839 342 110276109
Humerus fracture 11.80 10.32 61 312787 10715 110265736
Blood pressure diastolic increased 11.78 10.32 22 312826 18785 110257666
Paroxysmal arrhythmia 11.77 10.32 5 312843 59 110276392
Cancer pain 11.74 10.32 44 312804 6728 110269723
Viral infection 11.73 10.32 95 312753 53044 110223407
Spinal cord infarction 11.73 10.32 15 312833 1083 110275368
Obsessive-compulsive disorder 11.72 10.32 3 312845 7238 110269213
Kidney transplant rejection 11.70 10.32 10 312838 11977 110264474
Kidney rupture 11.69 10.32 8 312840 257 110276194
Scleral haemorrhage 11.68 10.32 7 312841 178 110276273
Puncture site pain 11.68 10.32 7 312841 178 110276273
Dermatitis exfoliative 11.66 10.32 9 312839 11338 110265113
Ovarian cancer 11.64 10.32 33 312815 4363 110272088
Spondylitis 11.64 10.32 9 312839 11329 110265122
Vascular pseudoaneurysm ruptured 11.64 10.32 11 312837 565 110275886
Peritonitis 11.63 10.32 50 312798 32557 110243894
Neoplasm 11.62 10.32 62 312786 11025 110265426
Aspiration pleural cavity 11.61 10.32 19 312829 1718 110274733
Vasculitic rash 11.60 10.32 22 312826 2235 110274216
Sensitivity to weather change 11.57 10.32 7 312841 10021 110266430
Disease prodromal stage 11.55 10.32 5 312843 62 110276389
Arterial injury 11.55 10.32 13 312835 821 110275630
Haemorrhagic arteriovenous malformation 11.54 10.32 11 312837 571 110275880
Cholecystitis 11.54 10.32 118 312730 25764 110250687
Cytomegalovirus chorioretinitis 11.45 10.32 3 312845 7125 110269326
Hypercalcaemia 11.44 10.32 81 312767 46576 110229875
Myelocytosis 11.44 10.32 7 312841 185 110276266
Mechanical ileus 11.42 10.32 16 312832 1261 110275190
Therapeutic embolisation 11.41 10.32 11 312837 579 110275872
Tricuspid valve disease 11.36 10.32 10 312838 468 110275983
Renal mass 11.35 10.32 29 312819 3606 110272845
Dyskinesia 11.35 10.32 92 312756 51354 110225097
Intestinal varices haemorrhage 11.33 10.32 3 312845 6 110276445
Acquired cardiac septal defect 11.33 10.32 3 312845 6 110276445
Nitrituria 11.33 10.32 3 312845 6 110276445
Device wireless communication issue 11.33 10.32 3 312845 6 110276445
Oesophagogastroduodenoscopy abnormal 11.33 10.32 3 312845 6 110276445
Product temperature excursion issue 11.33 10.32 13 312835 838 110275613
Aphasia 11.32 10.32 232 312616 58765 110217686
Basal ganglia haematoma 11.27 10.32 5 312843 66 110276385
Ventricular hypertrophy 11.25 10.32 3 312845 7042 110269409
Blood creatine abnormal 11.24 10.32 9 312839 369 110276082
Aortic valve incompetence 11.23 10.32 61 312787 10920 110265531
Immune thrombocytopenia 11.22 10.32 105 312743 22389 110254062
Urinary retention postoperative 11.22 10.32 8 312840 275 110276176
Antinuclear antibody positive 11.15 10.32 6 312842 9162 110267289
Blood pressure inadequately controlled 11.15 10.32 47 312801 7586 110268865
Respiratory sinus arrhythmia magnitude 11.14 10.32 5 312843 68 110276383
Red cell distribution width abnormal 11.14 10.32 8 312840 278 110276173
Tumour lysis syndrome 11.12 10.32 47 312801 30754 110245697
Swollen tongue 11.11 10.32 113 312735 60249 110216202
Blood viscosity decreased 11.08 10.32 5 312843 69 110276382
Drug specific antibody present 11.05 10.32 5 312843 8429 110268022
Vena cava thrombosis 11.04 10.32 28 312820 3466 110272985
Dialysis 11.03 10.32 94 312754 19525 110256926
Injection site discolouration 11.01 10.32 6 312842 9097 110267354
Intestinal ischaemia 11.01 10.32 81 312767 16098 110260353
Orbital haemorrhage 11.01 10.32 4 312844 30 110276421
Back disorder 11.00 10.32 27 312821 20895 110255556
Fibrin D dimer increased 10.97 10.32 56 312792 9789 110266662
Walking distance test abnormal 10.97 10.32 12 312836 734 110275717
Mixed dementia 10.97 10.32 8 312840 285 110276166
Skull fractured base 10.95 10.32 9 312839 383 110276068
Anal stenosis 10.92 10.32 11 312837 611 110275840
Primary adrenal insufficiency 10.89 10.32 11 312837 613 110275838
Pseudomonal sepsis 10.89 10.32 6 312842 9040 110267411
Eye pain 10.86 10.32 90 312758 50009 110226442
Pericarditis constrictive 10.84 10.32 14 312834 1021 110275430
Bipolar disorder 10.80 10.32 6 312842 9001 110267450
Parkinsonian rest tremor 10.79 10.32 9 312839 391 110276060
Clot retraction 10.78 10.32 4 312844 32 110276419
Factor V inhibition 10.78 10.32 9 312839 392 110276059
Angiogram 10.74 10.32 6 312842 133 110276318
Intercepted product preparation error 10.71 10.32 3 312845 6817 110269634
Left atrial dilatation 10.70 10.32 28 312820 3532 110272919
Essential thrombocythaemia 10.64 10.32 9 312839 399 110276052
Cardiac pacemaker evaluation 10.63 10.32 6 312842 136 110276315
Left ventricular hypertrophy 10.60 10.32 69 312779 13175 110263276
Dizziness exertional 10.59 10.32 12 312836 763 110275688
Immune-mediated myositis 10.57 10.32 40 312808 6146 110270305
Oesophageal infection 10.55 10.32 12 312836 766 110275685
Neutropenia 10.55 10.32 914 311934 373706 109902745
Foreign body 10.52 10.32 25 312823 2970 110273481
Gastric polyps 10.52 10.32 37 312811 5486 110270965
Blood immunoglobulin G abnormal 10.51 10.32 6 312842 139 110276312
Hepatitis B reactivation 10.51 10.32 4 312844 7480 110268971
Haemorrhagic erosive gastritis 10.50 10.32 12 312836 770 110275681
Rebound effect 10.49 10.32 16 312832 14790 110261661
Morganella infection 10.48 10.32 16 312832 1363 110275088
Hypogammaglobulinaemia 10.48 10.32 26 312822 20050 110256401
Elephantiasis 10.48 10.32 3 312845 9 110276442
Spinal cord haematoma 10.47 10.32 8 312840 306 110276145
Troponin abnormal 10.47 10.32 6 312842 140 110276311
Cardiac operation 10.44 10.32 39 312809 5956 110270495
Gynaecomastia 10.44 10.32 7 312841 9483 110266968
Heart valve operation 10.42 10.32 7 312841 218 110276233
Spinal cord abscess 10.39 10.32 11 312837 648 110275803
Overflow diarrhoea 10.36 10.32 7 312841 220 110276231
Face oedema 10.36 10.32 54 312794 33415 110243036
Jugular vein thrombosis 10.35 10.32 36 312812 5309 110271142

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AF02 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct factor Xa inhibitors
MeSH PA D000925 Anticoagulants
MeSH PA D000991 Antithrombins
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006401 Hematologic Agents
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors
MeSH PA D065427 Factor Xa Inhibitors
FDA MoA N0000175635 Factor Xa Inhibitors
FDA EPC N0000175637 Factor Xa Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:68581 EC 3.4.21.6 (coagulation factor Xa) inhibitor
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

B01AF Direct factor Xa inhibitors 4 drugs
acetylsalicylic acidbetrixabanedoxabanrivaroxaban

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Arterial embolus and thrombosis indication 266262004
Myocardial Reinfarction Prevention indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.89 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 April 17, 2025 RX TABLET, FOR SUSPENSION ORAL 6967208 Nov. 21, 2026 TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS WITH BODY WEIGHT FROM 4 TO LESS THAN 35 KG
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 PROPHYLAXIS OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 PROPHYLAXIS OF DEEP VEIN THROMBOSIS (DVT)
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 PROPHYLAXIS OF PULMONARY EMBOLISM
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCE THE RISK OF RECURRENT DEEP VEIN THROMBOSIS (DVT)
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCE THE RISK OF RECURRENT PULMONARY EMBOLISM
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCING THE RISK OF STROKE
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCING THE RISK OF STROKE AND SYSTEMIC EMBOLISM
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF DEEP VEIN THROMBOSIS (DVT)
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF PULMONARY EMBOLISM (PE)
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS WITH BODY WEIGHT GREATER THAN OR EQUAL TO 35 KG
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCING THE RISK OF STROKE
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 REDUCING THE RISK OF STROKE AND SYSTEMIC EMBOLISM
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF DEEP VEIN THROMBOSIS (DVT)
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF PULMONARY EMBOLISM (PE)
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL 6967208 Nov. 21, 2026 TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS WITH BODY WEIGHT GREATER THAN OR EQUAL TO 35 KG
0.15MG ELIQUIS SPRINKLE BRISTOL N220073 April 17, 2025 RX FOR SUSPENSION ORAL 6967208 Nov. 21, 2026 TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS WITH BODY WEIGHT FROM 2.6 TO LESS THAN 4 KG
0.15MG ELIQUIS SPRINKLE BRISTOL N220073 April 17, 2025 RX FOR SUSPENSION ORAL 11896586 Nov. 22, 2040 TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) AND REDUCTION IN THE RISK OF RECURRENT VTE IN PEDIATRIC PATIENTS WITH BODY WEIGHT FROM 2.6 TO LESS THAN 4 KG

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 April 17, 2025 RX TABLET, FOR SUSPENSION ORAL April 17, 2028 NEW STRENGTH
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL April 17, 2028 NEW PATIENT POPULATION
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL April 17, 2028 NEW PATIENT POPULATION
0.15MG ELIQUIS SPRINKLE BRISTOL N220073 April 17, 2025 RX FOR SUSPENSION ORAL April 17, 2028 NEW PRODUCT
0.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 April 17, 2025 RX TABLET, FOR SUSPENSION ORAL Oct. 17, 2028 PEDIATRIC EXCLUSIVITY
2.5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL Oct. 17, 2028 PEDIATRIC EXCLUSIVITY
5MG ELIQUIS BRISTOL MYERS SQUIBB N202155 Dec. 28, 2012 RX TABLET ORAL Oct. 17, 2028 PEDIATRIC EXCLUSIVITY
0.15MG ELIQUIS SPRINKLE BRISTOL N220073 April 17, 2025 RX FOR SUSPENSION ORAL Oct. 17, 2028 PEDIATRIC EXCLUSIVITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Coagulation factor X Enzyme INHIBITOR Ki 10.10 CHEMBL CHEMBL
Prothrombin Enzyme Ki 5.51 CHEMBL
Coagulation factor X Enzyme Ki 9.77 CHEMBL

External reference:

IDSource
4031957 VUID
N0000186136 NUI
D03213 KEGG_DRUG
4031957 VANDF
CHEBI:72296 CHEBI
CHEMBL231779 ChEMBL_ID
C522181 MESH_SUPPLEMENTAL_RECORD_UI
6390 IUPHAR_LIGAND_ID
8626 INN_ID
DB06605 DRUGBANK_ID
3Z9Y7UWC1J UNII
1364430 RXNORM
185767 MMSL
28142 MMSL
d07804 MMSL
013857 NDDF
698090000 SNOMEDCT_US
703906002 SNOMEDCT_US
C1831808 UMLSCUI
GG2 PDB_CHEM_ID
10182969 PUBCHEM_CID
3Z9Y7UWC1J INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 0003-0893 TABLET, FILM COATED 2.50 mg ORAL NDA 32 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 0003-0894 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Apixaban HUMAN PRESCRIPTION DRUG LABEL 1 0115-1721 TABLET, FILM COATED 2.50 mg ORAL ANDA 29 sections
Apixaban HUMAN PRESCRIPTION DRUG LABEL 1 0115-1722 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
apixaban Human Prescription Drug Label 1 14445-149 TABLET, FILM COATED 2.50 mg ORAL ANDA 29 sections
apixaban Human Prescription Drug Label 1 14445-150 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
Apixaban Human Prescription Drug Label 1 33342-337 TABLET, FILM COATED 2.50 mg ORAL ANDA 28 sections
Apixaban Human Prescription Drug Label 1 33342-338 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-1436 TABLET, FILM COATED 2.50 mg ORAL NDA 29 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-1437 TABLET, FILM COATED 5 mg ORAL NDA 29 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-6451 TABLET, FILM COATED 2.50 mg ORAL NDA 30 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 50090-6454 TABLET, FILM COATED 5 mg ORAL NDA 30 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 55154-0612 TABLET, FILM COATED 2.50 mg ORAL NDA 31 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 55154-0613 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 67296-1673 TABLET, FILM COATED 5 mg ORAL NDA 31 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 70518-4462 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 71610-662 TABLET, FILM COATED 5 mg ORAL NDA 30 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 71610-811 TABLET, FILM COATED 2.50 mg ORAL NDA 30 sections
ELIQUIS HUMAN PRESCRIPTION DRUG LABEL 1 82804-085 TABLET, FILM COATED 5 mg ORAL NDA 30 sections