pyrithione zinc

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Stem definition	Drug id	CAS RN
	4248	13463-41-7

Stem definition

Drug id

CAS RN

4248

13463-41-7

Description:

Molecule	Description
Synonyms: pyrithione zinc zinc pyrithione	dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon; antifungal and antibacterial Molecular weight: 317.69 Formula: C10H8N2O2S2Zn CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

pyrithione zinc
zinc pyrithione

dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon; antifungal and antibacterial

Molecular weight: 317.69
Formula: C10H8N2O2S2Zn
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Date	Agency	Company	Orphan
None	FDA

Date

Agency

Company

Orphan

None

FDA

Source	Code	Description
ATC	D11AX12	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D007641	Keratolytic Agents

Source

Code

Description

ATC

D11AX12

DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals

MeSH PA

D003879

Dermatologic Agents

MeSH PA

D007641

Keratolytic Agents

Disease	Relation	SNOMED_ID	DOID
Seborrheic dermatitis	indication	50563003	DOID:8741
Pityriasis simplex	indication	200767005

Disease

Relation

SNOMED_ID

DOID

Seborrheic dermatitis

indication

50563003

DOID:8741

Pityriasis simplex

indication

200767005

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.21	CHEMBL
Potassium voltage-gated channel subfamily KQT member 2	Ion channel	O43526	KCNQ2_HUMAN	ACTIVATOR	EC50	5.80	IUPHAR
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	5.76	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	5.27	CHEMBL
Potassium voltage-gated channel subfamily KQT member 1	Ion channel	P51787	KCNQ1_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	5.29	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	5.45	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	5.11	CHEMBL
Potassium voltage-gated channel subfamily KQT member 5	Ion channel	Q9NR82	KCNQ5_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	5.79	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	5.62	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	5.54	CHEMBL
Potassium voltage-gated channel subfamily KQT member 4	Ion channel	P56696	KCNQ4_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Ki	5.38	CHEMBL

Target

Class

Pharos

UniProt

Action

Type

Activity value
(-log[M])

Mechanism
action

Bioact source

MoA source

Carbonic anhydrase 4

Enzyme

P22748

CAH4_HUMAN

5.21

CHEMBL

Potassium voltage-gated channel subfamily KQT member 2

Ion channel

O43526

KCNQ2_HUMAN

ACTIVATOR

EC50

5.80

IUPHAR

Carbonic anhydrase 9

Enzyme

Q16790

CAH9_HUMAN

5.76

CHEMBL

Carbonic anhydrase 12

Enzyme

O43570

CAH12_HUMAN

5.27

CHEMBL

Potassium voltage-gated channel subfamily KQT member 1

Ion channel

P51787

KCNQ1_HUMAN

ACTIVATOR

EC50

IUPHAR

Carbonic anhydrase 5A, mitochondrial

Enzyme

P35218

CAH5A_HUMAN

5.29

CHEMBL

Carbonic anhydrase 5B, mitochondrial

Enzyme

Q9Y2D0

CAH5B_HUMAN

5.45

CHEMBL

Carbonic anhydrase 7

Enzyme

P43166

CAH7_HUMAN

5.11

CHEMBL

Potassium voltage-gated channel subfamily KQT member 5

Ion channel

Q9NR82

KCNQ5_HUMAN

ACTIVATOR

EC50

IUPHAR

Carbonic anhydrase 3

Enzyme

P07451

CAH3_HUMAN

5.79

CHEMBL

Carbonic anhydrase 6

Enzyme

P23280

CAH6_HUMAN

5.62

CHEMBL

Carbonic anhydrase 14

Enzyme

Q9ULX7

CAH14_HUMAN

5.54

CHEMBL

Potassium voltage-gated channel subfamily KQT member 4

Ion channel

P56696

KCNQ4_HUMAN

ACTIVATOR

EC50

IUPHAR

Carbonic anhydrase 13

Enzyme

Q8N1Q1

CAH13_HUMAN

5.38

CHEMBL

External reference:

ID	Source
4020508	VUID
N0000179286	NUI
D01938	KEGG_DRUG
4019187	VANDF
4020508	VANDF
C0078792	UMLSCUI
CHEBI:32076	CHEBI
CHEMBL1200471	ChEMBL_ID
C010423	MESH_SUPPLEMENTAL_RECORD_UI
2295	INN_ID
R953O2RHZ5	UNII
26041	PUBCHEM_CID
39952	RXNORM
4999	MMSL
5397	MMSL
002961	NDDF
255954005	SNOMEDCT_US
411297004	SNOMEDCT_US
2597	IUPHAR_LIGAND_ID
R953O2RHZ5	INXIGHT DRUGS

Source

4020508

VUID

N0000179286

NUI

D01938

KEGG_DRUG

4019187

VANDF

4020508

VANDF

C0078792

UMLSCUI

CHEBI:32076

CHEBI

CHEMBL1200471

ChEMBL_ID

C010423

MESH_SUPPLEMENTAL_RECORD_UI

INN_ID

UNII

PUBCHEM_CID

RXNORM

4999

MMSL

5397

MMSL

002961

NDDF

SNOMEDCT_US

SNOMEDCT_US

IUPHAR_LIGAND_ID

INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DHS ZINC	HUMAN OTC DRUG LABEL	1	0096-0735	SHAMPOO	20 mg	TOPICAL	OTC Monograph Drug	8 sections
DHS ZINC	HUMAN OTC DRUG LABEL	1	0096-0735	SHAMPOO	20 mg	TOPICAL	OTC Monograph Drug	8 sections
DHS Body Wash	HUMAN OTC DRUG LABEL	1	0096-0742	LIQUID	50 mg	TOPICAL	OTC Monograph Drug	9 sections
DHS ZINC	HUMAN OTC DRUG LABEL	1	0096-0811	SHAMPOO	20 mg	TOPICAL	OTC Monograph Drug	13 sections
DHS BODY WASH	HUMAN OTC DRUG LABEL	1	0096-0814	LIQUID	5 mg	TOPICAL	OTC Monograph Drug	12 sections
Walgreens Everyday Clean DandruffAnti-Dandruff	HUMAN OTC DRUG LABEL	1	0363-2606	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Dandruff Itchy Dry Scalp DefenseAnti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4138	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Dandruff Conditioner 2 in 1 Itchy ScalpAnti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4288	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Dandruff Conditioner 2 in 1 Itchy ScalpAnti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4289	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Dandruff Plus Conditioner 2 in 1 Dry ScalpAnti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4666	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Dandruff Plus Conditioner 2 in 1Anti-dandruff	HUMAN OTC DRUG LABEL	1	0363-4673	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Satinique Anti Dandruff	HUMAN OTC DRUG LABEL	1	10056-006	CREAM	9.50 mg	TOPICAL	OTC Monograph Drug	9 sections
Advance Techniques Keep ClearAnti-Dandruff Treatment	HUMAN OTC DRUG LABEL	1	10096-0220	LOTION	0.15 mL	TOPICAL	OTC monograph final	10 sections
Advance Techniques Keep Clear2-in-1 Anti-Dandruff	HUMAN OTC DRUG LABEL	1	10096-0221	SHAMPOO	10 mg	TOPICAL	OTC monograph final	11 sections
American Crew	HUMAN OTC DRUG LABEL	1	10967-650	SHAMPOO	1 mg	TOPICAL	OTC Monograph Drug	8 sections
Pyrithione Zinc	HUMAN OTC DRUG LABEL	1	11344-131	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	12 sections
Dandruff	HUMAN OTC DRUG LABEL	1	11344-153	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	12 sections
Just For Men Control GX Anti-Dandruff	HUMAN OTC DRUG LABEL	1	11509-5225	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	12 sections
Everyday Clean Dandruff	HUMAN OTC DRUG LABEL	1	11673-153	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
2 in 1 Dandruff	HUMAN OTC DRUG LABEL	1	11673-643	SHAMPOO	10 mg	TOPICAL	OTC Monograph Drug	13 sections
Rite Aid Dandruff2 in 1 Classic Clean	HUMAN OTC DRUG LABEL	1	11822-4101	SHAMPOO	1 mL	TOPICAL	OTC monograph final	10 sections
Rite Aid Dandruff2 in 1 Dry Scalp Care	HUMAN OTC DRUG LABEL	1	11822-4111	SHAMPOO	1 mL	TOPICAL	OTC monograph final	10 sections
Daylogic 2in1 Dandruff Classic Clean	HUMAN OTC DRUG LABEL	1	11822-4242	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic 2in1 Dandruff Classic Clean	HUMAN OTC DRUG LABEL	1	11822-4242	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic 2in1 Dandruff Dry Scalp Care	HUMAN OTC DRUG LABEL	1	11822-4251	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic 2in1 Dandruff Dry Scalp Care	HUMAN OTC DRUG LABEL	1	11822-4251	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic Dandruff Classic Clean	HUMAN OTC DRUG LABEL	1	11822-4272	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic Dandruff Classic Clean	HUMAN OTC DRUG LABEL	1	11822-4272	LIQUID	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic Dry Scalp Dandruff	HUMAN OTC DRUG LABEL	1	11822-4292	SHAMPOO	10 mg	TOPICAL	OTC monograph final	10 sections
Daylogic Dry Scalp Dandruff	HUMAN OTC DRUG LABEL	1	11822-4292	SHAMPOO	10 mg	TOPICAL	OTC monograph final	10 sections

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pyrithione zinc 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: